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METTL3 in Cr (VI)-induced carcinogenesis and CXCL6 expression associated with lung cancer development METTL3在Cr （VI）诱导的癌变和CXCL6表达与肺癌发展相关
IF 9.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Genes & Diseases
Pub Date : 2025-07-24 DOI: 10.1016/j.gendis.2025.101778
Jie Liu , Xiao Han , Fan-Li Sun , Xue Wang , Lin Wang , Yan-Qiu Zhao , Wen-Jing Liu , Bing-Hua Jiang
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引用次数: 0
Bmp9 modulates cell proliferation and intercellular junctions in HERS during tooth root development Bmp9调节牙根发育过程中HERS的细胞增殖和细胞间连接
IF 9.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Genes & Diseases
Pub Date : 2025-07-23 DOI: 10.1016/j.gendis.2025.101777
Chang Liu , Hongyan Yuan , Jindie Huang , Shidian Ran , Xiaorui Wei , Xingrui Yan , Linyu Xue , Tong-Chuan He , Yuxin Zhang , Mengqin Gu , Si Wu , Fugui Zhang , Wenping Luo , Hongmei Zhang
Tooth formation is a highly orchestrated process that precisely regulates the size and shape of the tooth. During typical tooth development, Hertwig's epithelial root sheath (HERS) interacts with mesenchymal cells to direct the elongation of the tooth root and the deposition of dentin and cementum, thereby contributing to the formation of a fully developed tooth root. BMP9, a member of the BMP family, plays a significant role in growth, development, and cell differentiation. However, the precise function of BMP9 in dental root development remains unclear, particularly regarding its influence on HERS and odontoblasts. In this study, we utilized a mouse molar model to investigate the role of BMP9 signaling in tooth root development. The tooth formation of Bmp9 knockout (Bmp9-KO) mice and wild-type (WT) littermates was compared. Our findings revealed that Bmp9-KO mice exhibited shorter mandibular first molar roots, wider apical foramina, and thinner dentin compared with WT mice by micro-CT and hematoxylin-eosin staining analysis. Additionally, the results of immunohistochemistry and quantitative PCR indicated that in the absence of Bmp9, odontoblast differentiation and secretory function were compromised. Furthermore, Bmp9 ablation resulted in reduced cell proliferation and increased intercellular junctions within HERS, subsequently impacting root dentin formation and apical foramen closure. This study offers new insights into the regulatory role of BMP9 signaling in odontoblast and HERS function, highlighting its significance in root development and providing potential avenues for future research in tooth root regeneration.
牙齿的形成是一个高度协调的过程，它精确地调节着牙齿的大小和形状。在典型的牙齿发育过程中，Hertwig’s上皮根鞘（Hertwig’s epithelial root sheath， HERS）与间充质细胞相互作用，指导牙根的伸长以及牙本质和牙骨质的沉积，从而促进了牙根发育完全的形成。BMP9是BMP家族的一员，在生长、发育和细胞分化中起重要作用。然而，BMP9在牙根发育中的确切功能尚不清楚，特别是其对HERS和成牙细胞的影响。在这项研究中，我们利用小鼠磨牙模型来研究BMP9信号在牙根发育中的作用。比较Bmp9基因敲除（Bmp9- ko）小鼠和野生型（WT）幼崽的牙齿形成情况。结果表明，与WT小鼠相比，Bmp9-KO小鼠下颌第一磨牙根变短，根尖孔变宽，牙本质变薄。此外，免疫组织化学和定量PCR结果表明，在缺乏Bmp9的情况下，成牙细胞分化和分泌功能受到损害。此外，Bmp9消融导致HERS内细胞增殖减少，细胞间连接增加，从而影响根本质形成和根尖孔关闭。本研究为BMP9信号在成牙细胞和HERS功能中的调控作用提供了新的见解，突出了其在牙根发育中的重要性，为未来牙根再生的研究提供了潜在的途径。
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引用次数: 0
Polymorphisms of mismatch repair pathway genes predict clinical outcomes in acute myeloid leukemia patients 错配修复途径基因多态性预测急性髓性白血病患者的临床预后
IF 9.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Genes & Diseases
Pub Date : 2025-07-16 DOI: 10.1016/j.gendis.2025.101774
Amin Zhang , Wancheng Liu , Can Can , Xiaodong Guo , Hexiao Jia , Yihong Wei , Hanyang Wu , Chunyan Ji , Daoxin Ma
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引用次数: 0
LRRC8A: A multifaceted regulator in cancer, neurological disorders, metabolic diseases and immune modulation LRRC8A：癌症、神经系统疾病、代谢疾病和免疫调节的多层面调控因子
IF 9.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Genes & Diseases
Pub Date : 2025-07-16 DOI: 10.1016/j.gendis.2025.101773
Longjun Yang, Qiang Ding, Xiaoyu Ji, Panpan Lu, Mei Liu
Leucine-rich repeat containing 8A (LRRC8A) is a member of the LRRC8 family, exhibiting broad expression across various tissues and cells in vertebrates. Like other LRRC8 family members, LRRC8A contributes to the formation of volume-regulated anion channels (VRACs), which are crucial for regulating cell volume and maintaining homeostasis. LRRC8A participates in diverse signaling pathways. Multiple studies have validated the links between LRRC8A dysregulation and neurological disorders, metabolic ailments, and tumors. This review provides a comprehensive overview of the regulatory mechanisms of LRRC8A in these pathologies. The primary goal was to assess the potential of LRRC8A as a therapeutic target for treating diseases and address key unresolved issues.
富含亮氨酸重复序列（Leucine-rich repeat containing 8A, LRRC8A）是LRRC8家族的成员，在脊椎动物的多种组织和细胞中广泛表达。与其他LRRC8家族成员一样，LRRC8A有助于形成体积调节阴离子通道（vrac），这对于调节细胞体积和维持体内平衡至关重要。LRRC8A参与多种信号通路。多项研究证实了LRRC8A失调与神经系统疾病、代谢疾病和肿瘤之间的联系。本文综述了LRRC8A在这些病理中的调控机制。主要目标是评估LRRC8A作为治疗疾病的治疗靶点的潜力，并解决关键的未解决问题。
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引用次数: 0
The biomechanical signature of tumor invasion 肿瘤侵袭的生物力学特征
IF 9.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Genes & Diseases
Pub Date : 2025-07-14 DOI: 10.1016/j.gendis.2025.101771
Chenhe Liu , Shijiang Wang , Xin Zhang , Yifan Han , Min Tan , Jiehou Fan , Jing Du , Yubo Fan , Xinbin Zhao
Tumor cell invasion is the key driver of metastatic dissemination, resulting in the development and progression of metastatic tumors at secondary sites, and remains the major cause of cancer-related death. Recent studies suggest that, in addition to protease-mediated degradation and chemotaxis-stimulated migration, tumor invasion is significantly influenced by physical surroundings. How tumor cells decode information about their shape deformation under mechanical stress and adapt their dynamic behavior to escape the confined regions remains largely unknown. This review highlights recent findings that illustrate mechanical cues in confined tumor microenvironment contribute to tumor progression. We also systematically discuss the role of compression-induced deformation in cell membrane topology and cytoskeletal remodeling, as well as its biophysical mechanisms in regulating tumor invasion from a biomechanical perspective.
肿瘤细胞侵袭是转移性扩散的关键驱动因素，导致继发性转移性肿瘤的发生和进展，并且仍然是癌症相关死亡的主要原因。最近的研究表明，除了蛋白酶介导的降解和趋化刺激的迁移外，肿瘤的侵袭还受到物理环境的显著影响。肿瘤细胞如何在机械应力下解码其形状变形的信息，并适应其动态行为以逃离受限区域，这在很大程度上仍是未知的。这篇综述强调了最近的研究结果，说明在受限的肿瘤微环境中，机械信号有助于肿瘤的进展。我们还从生物力学的角度系统地讨论了压缩变形在细胞膜拓扑结构和细胞骨架重塑中的作用，以及其在调节肿瘤侵袭中的生物物理机制。
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引用次数: 0
Fatty acid metabolic reprogramming in the tumor microenvironment: Unraveling mechanisms and therapeutic prospects 肿瘤微环境中的脂肪酸代谢重编程：揭示机制和治疗前景
IF 9.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Genes & Diseases
Pub Date : 2025-07-14 DOI: 10.1016/j.gendis.2025.101772
Wenxin Zhang , Peiwen Wang , Guiqiang Yuan , Fusheng Liu , Guishan Jin , Junwen Zhang
Lipid metabolic reprogramming has emerged as a hallmark in cancer research, especially that of fatty acids (FAs). It promotes the effective utilization of the limited nutrients in the tumor microenvironment (TME) by the cells and has considerably been associated with immune escape. Tumor cells exhibit enhanced FA uptake, synthesis, and oxidation for metabolic adaptation, and non-tumor cells also undergo FA metabolic remolding in the TME. Owing to the essential role of FA metabolism in TME, the associated critical enzymes may be targeted for developing novel therapeutic approaches. This review aims to comprehensively summarize the FA metabolic landscapes in various cancers and FA-related molecular changes, FA metabolic reprogramming in different cells in the TME to identify potential targets, and FA-related cell interactions and underlying mechanisms in the TME. The findings of this study may provide insights into exploring the intricate FA metabolism–TME adaptation interplay to uncover potential metabolic targets of therapeutic significance for combinatorial strategies and enhancing immunotherapy.
脂质代谢重编程已成为癌症研究的一个标志，尤其是脂肪酸（FAs）。它促进细胞有效利用肿瘤微环境（TME）中有限的营养物质，并与免疫逃逸密切相关。肿瘤细胞表现出增强的FA摄取、合成和氧化以适应代谢，非肿瘤细胞也在TME中经历FA代谢重塑。由于FA代谢在TME中的重要作用，相关的关键酶可能成为开发新的治疗方法的目标。本文旨在全面综述FA在各种癌症中的代谢景观和FA相关的分子变化，FA在TME不同细胞中的代谢重编程以确定潜在靶点，以及FA在TME中相关的细胞相互作用和潜在机制。本研究结果可能为探索复杂的FA代谢- tme适应相互作用提供见解，以揭示潜在的代谢靶点，为组合策略和增强免疫治疗提供治疗意义。
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引用次数: 0
Multi-omics analysis of lactylation as a prognostic signature: A pan-cancer study 作为预后标志的乳酸化多组学分析：一项泛癌症研究
IF 9.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Genes & Diseases
Pub Date : 2025-07-12 DOI: 10.1016/j.gendis.2025.101769
Xinning Liu , Yanping Wang , Yufeng Cao , Jinbao Zong
{"title":"Multi-omics analysis of lactylation as a prognostic signature: A pan-cancer study","authors":"Xinning Liu ,&nbsp;Yanping Wang ,&nbsp;Yufeng Cao ,&nbsp;Jinbao Zong","doi":"10.1016/j.gendis.2025.101769","DOIUrl":"10.1016/j.gendis.2025.101769","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 2","pages":"Article 101769"},"PeriodicalIF":9.4,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145577042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The regulatory role of CASZ1 in keratinocyte differentiation and skin barrier function in atopic dermatitis CASZ1在特应性皮炎中角化细胞分化和皮肤屏障功能中的调节作用
IF 9.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Genes & Diseases
Pub Date : 2025-07-11 DOI: 10.1016/j.gendis.2025.101767
Xuemei Li , Yuqiong Huang , Changdeok Kim , Li Fu , Hongxiang Chen , Kyungeun Jung
{"title":"The regulatory role of CASZ1 in keratinocyte differentiation and skin barrier function in atopic dermatitis","authors":"Xuemei Li ,&nbsp;Yuqiong Huang ,&nbsp;Changdeok Kim ,&nbsp;Li Fu ,&nbsp;Hongxiang Chen ,&nbsp;Kyungeun Jung","doi":"10.1016/j.gendis.2025.101767","DOIUrl":"10.1016/j.gendis.2025.101767","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 1","pages":"Article 101767"},"PeriodicalIF":9.4,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
m6A modification erased by ALKBH5 promotes tumor growth and metastasis via regulation of YAP/ZEB1 axis in NSCLC 在非小细胞肺癌中，ALKBH5清除m6A修饰通过调控YAP/ZEB1轴促进肿瘤生长和转移
IF 9.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Genes & Diseases
Pub Date : 2025-07-11 DOI: 10.1016/j.gendis.2025.101768
Dan Jin , Weihua Di , Rui Li , Shuang Shao , Jiwei Guo
{"title":"m6A modification erased by ALKBH5 promotes tumor growth and metastasis via regulation of YAP/ZEB1 axis in NSCLC","authors":"Dan Jin ,&nbsp;Weihua Di ,&nbsp;Rui Li ,&nbsp;Shuang Shao ,&nbsp;Jiwei Guo","doi":"10.1016/j.gendis.2025.101768","DOIUrl":"10.1016/j.gendis.2025.101768","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"13 2","pages":"Article 101768"},"PeriodicalIF":9.4,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145414202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemophagocytic lymphohistiocytosis: Unraveling the role of SARS-CoV-2 infection 噬血细胞淋巴组织细胞病：揭示SARS-CoV-2感染的作用
IF 9.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Genes & Diseases
Pub Date : 2025-07-09 DOI: 10.1016/j.gendis.2025.101764
Erin Murphy, Krzysztof Data, Dominika Domagała, Julia Niebora, Artur Bryja, Małgorzata Józkowiak, Hanna Piotrowska-Kempisty, Piotr Dziegiel, Bartosz Kempisty, Paul Mozdziak
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