Pub Date : 2024-08-23DOI: 10.1016/j.gendis.2024.101395
Xiaoxue Jiang , Libo Xing , Yi Lu , Rushi Qin , Liyan Wang , Shuting Song , Xinlei Liu , Sijie Xie , Shujie Li , Dongdong Lu
{"title":"CARM1 accelerates the growth of liver cancer cells by enhancing ARAF","authors":"Xiaoxue Jiang , Libo Xing , Yi Lu , Rushi Qin , Liyan Wang , Shuting Song , Xinlei Liu , Sijie Xie , Shujie Li , Dongdong Lu","doi":"10.1016/j.gendis.2024.101395","DOIUrl":"10.1016/j.gendis.2024.101395","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 1","pages":"Article 101395"},"PeriodicalIF":6.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-23DOI: 10.1016/j.gendis.2024.101396
Shang Gao , Ping Sun , Zekun Wang , Yecheng Jin , Wenjie Sun , Xi Li , Ruonan Duan , Jiangxia Li , Qiji Liu
{"title":"TMEM132E ablation suppresses tumor progression and restores tamoxifen sensitivity by inducing ERα expression in triple-negative breast cancer","authors":"Shang Gao , Ping Sun , Zekun Wang , Yecheng Jin , Wenjie Sun , Xi Li , Ruonan Duan , Jiangxia Li , Qiji Liu","doi":"10.1016/j.gendis.2024.101396","DOIUrl":"10.1016/j.gendis.2024.101396","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101396"},"PeriodicalIF":6.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-19DOI: 10.1016/j.gendis.2024.101392
Haibin Jiang , Mengyan Tang , Zidi Xu , Yanan Wang , Mopu Li , Shuyin Zheng , Jianghu Zhu , Zhenlang Lin , Min Zhang
{"title":"Corrigendum to ‘CRISPR/Cas9 system and its applications in nervous system diseases’ [Genes & Diseases 11 (2024) 675–686]","authors":"Haibin Jiang , Mengyan Tang , Zidi Xu , Yanan Wang , Mopu Li , Shuyin Zheng , Jianghu Zhu , Zhenlang Lin , Min Zhang","doi":"10.1016/j.gendis.2024.101392","DOIUrl":"10.1016/j.gendis.2024.101392","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"11 6","pages":"Article 101392"},"PeriodicalIF":6.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352304224001892/pdfft?md5=c910765c36207473a3c635a7466d2401&pid=1-s2.0-S2352304224001892-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Construction of a prognostic model based on the cuproptosis-related genes in pancreatic cancer","authors":"Kaili Liao, Yuxin Fu, Shuman Guo, Tingyi Qian, Feifei Teng, Yuhan Xu, Bing Sun, Hanqing Zhao, Jingyan Zhang, Ranhao Fan, Jie Gao, Xiaozhong Wang","doi":"10.1016/j.gendis.2024.101391","DOIUrl":"https://doi.org/10.1016/j.gendis.2024.101391","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"16 1","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-09DOI: 10.1016/j.gendis.2024.101389
Yimeng Qiao, Nan Lv, Tongchuan Li, Ye Cheng, Yunqian Li, Jiqiang Dong, Meimei Han, Yang Gu, Qing Shang, Qinghe Xing
{"title":"Clinically relevant variants detected in Chinese children with global developmental delay/intellectual disability: An exome-wide sequencing study","authors":"Yimeng Qiao, Nan Lv, Tongchuan Li, Ye Cheng, Yunqian Li, Jiqiang Dong, Meimei Han, Yang Gu, Qing Shang, Qinghe Xing","doi":"10.1016/j.gendis.2024.101389","DOIUrl":"https://doi.org/10.1016/j.gendis.2024.101389","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"42 1","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-09DOI: 10.1016/j.gendis.2024.101388
Xudong Su, Jianye Yang, Zhenghao Xu, Li Wei, Shuhao Yang, Feilong Li, Min Sun, Yingkun Hu, Wenge He, Chen Zhao, Li Chen, Yonghua Yuan, Leilei Qin, Ning Hu
Macrophages play a key role in wound healing. Dysfunction of their M0 polarization to M2 leads to disorders of the wound immune microenvironment and chronic inflammation, which affects wound healing. Regulating the polarization of M0 macrophages to M2 macrophages is an effective strategy for treating wound healing. Mesenchymal stem cells (MSCs) deliver endogenous regulatory factors via paracrine extracellular vesicles, which may play a key role in wound healing, and previous studies have shown that apoptotic bodies (ABs) are closely associated with inflammation regression and macrophage polarization. However, the specific regulatory mechanisms involved in ABs remain unknown. In the present study, we designed an MSC-AB (MSC-derived AB)-loaded polycaprolactone (PCL) scaffold, evaluated the macrophage phenotype and skin wound inflammation and , and explored the ability of MSC-AB-loaded PCL scaffolds to promote wound healing. Our data suggest that the PCL scaffold regulates the expression of the CCL-1 gene by targeting the delivery of mmu-miR-21a-5p by local sustained-release MSC-ABs, and drives M0 macrophages to program M2 macrophages to regulate inflammation and angiogenesis, thereby synergistically promoting wound healing. This study provides a promising therapeutic strategy and experimental basis for treating various diseases associated with imbalances in proinflammatory and anti-inflammatory immune responses.
{"title":"Fibrous scaffolds loaded with BMSC-derived apoptotic vesicles promote wound healing by inducing macrophage polarization","authors":"Xudong Su, Jianye Yang, Zhenghao Xu, Li Wei, Shuhao Yang, Feilong Li, Min Sun, Yingkun Hu, Wenge He, Chen Zhao, Li Chen, Yonghua Yuan, Leilei Qin, Ning Hu","doi":"10.1016/j.gendis.2024.101388","DOIUrl":"https://doi.org/10.1016/j.gendis.2024.101388","url":null,"abstract":"Macrophages play a key role in wound healing. Dysfunction of their M0 polarization to M2 leads to disorders of the wound immune microenvironment and chronic inflammation, which affects wound healing. Regulating the polarization of M0 macrophages to M2 macrophages is an effective strategy for treating wound healing. Mesenchymal stem cells (MSCs) deliver endogenous regulatory factors via paracrine extracellular vesicles, which may play a key role in wound healing, and previous studies have shown that apoptotic bodies (ABs) are closely associated with inflammation regression and macrophage polarization. However, the specific regulatory mechanisms involved in ABs remain unknown. In the present study, we designed an MSC-AB (MSC-derived AB)-loaded polycaprolactone (PCL) scaffold, evaluated the macrophage phenotype and skin wound inflammation and , and explored the ability of MSC-AB-loaded PCL scaffolds to promote wound healing. Our data suggest that the PCL scaffold regulates the expression of the CCL-1 gene by targeting the delivery of mmu-miR-21a-5p by local sustained-release MSC-ABs, and drives M0 macrophages to program M2 macrophages to regulate inflammation and angiogenesis, thereby synergistically promoting wound healing. This study provides a promising therapeutic strategy and experimental basis for treating various diseases associated with imbalances in proinflammatory and anti-inflammatory immune responses.","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"172 1","pages":""},"PeriodicalIF":6.8,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-08DOI: 10.1016/j.gendis.2024.101387
Shuxin Yang , Juan Liu , Shengxin Luo , Wentao Wang , Jingxiang Xu
{"title":"NOP56 promotes hepatocellular carcinoma progression through 2′-O-methylation","authors":"Shuxin Yang , Juan Liu , Shengxin Luo , Wentao Wang , Jingxiang Xu","doi":"10.1016/j.gendis.2024.101387","DOIUrl":"10.1016/j.gendis.2024.101387","url":null,"abstract":"","PeriodicalId":12689,"journal":{"name":"Genes & Diseases","volume":"12 2","pages":"Article 101387"},"PeriodicalIF":6.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142198745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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