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Expanded Endoscopic Endonasal Approach and Adjuvant Radiotherapy for the Treatment of Locally Advanced Sinonasal and Skull Base Adenoid Cystic Carcinoma: Case Report and Literature Review 扩大内镜鼻内入路及辅助放疗治疗局部晚期鼻窦及颅底腺样囊性癌一例报告及文献复习
Pub Date : 2021-01-25 DOI: 10.19080/gjo.2021.24.556126
Judith Vásconez Escobar
Introduction: Adenoid Cystic Carcinoma of the sinonasal and skull base region is a challenging tumor to treat due to its late onset of presentation and frequent compromise of vital neurovascular structures. Surgical treatment followed by conventional irradiation are the optimal treatment options, often requiring extensive open approaches and mutilating interventions due to its localization. Endoscopic endonasal approaches are relatively new procedures that combined with new adjuvant radiation techniques could achieve similar oncological outcomes with significant less morbidity. Methods: We present the case of a patient with non-metastatic Adenoid Cystic Carcinoma (ACC) locally advanced of the sinonasal and skull base region diagnosed and treated at the Instituto Nacional de Cancerología of Bogotá D.C, Colombia between the years 2017 and 2020 who underwent endoscopic endonasal tumor resection and subsequent adjuvant management with Intensity modulated radiotherapy (IMRT). Results: Endoscopic and imaging control was performed according to the protocol of the surgical group with nasal endoscopies every 3-4 months during the first 2 years and serial images every 6 months. Follow up for 35 months with adequate local control and minimal aesthetic or functional sequelae. Conclusion: Multidisciplinary management with endoscopic endonasal resection and adjuvant radiotherapy appears to be an effective oncological alternative to open surgical procedures, with less morbid and minor functional sequelae, for patients with locally advanced ACC tumors of the sinonasal region.
摘要:鼻窦及颅底区腺样囊性癌是一种具有挑战性的肿瘤,因其发病较晚且经常损害重要的神经血管结构。手术治疗后再进行常规照射是最佳的治疗选择,由于其局限性,通常需要广泛的开放入路和致残干预。内镜下鼻内入路是相对较新的手术,与新的辅助放射技术相结合,可以达到相似的肿瘤结果,发病率显著降低。方法:我们报告了一例在2017年至2020年期间在哥伦比亚波哥大特区Cancerología国家研究所诊断和治疗的鼻窦和颅底区域局部晚期非转移性腺样囊性癌(ACC)患者,该患者接受了内镜鼻内肿瘤切除术和随后的调强放疗(IMRT)辅助治疗。结果:内镜和影像学对照按照手术组方案进行,前2年每3-4个月进行鼻内镜检查,每6个月进行连续影像学检查。随访35个月,局部控制良好,美观或功能后遗症最小。结论:对于鼻窦区局部晚期ACC肿瘤患者,内镜下鼻内切除术和辅助放疗的多学科治疗似乎是开放手术的有效替代方法,发病率低,功能后遗症小。
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引用次数: 0
Management of Sensorineural Deafness in Temporal Bone Trauma: A Report of 23 Cases 颞骨外伤后感音神经性耳聋的治疗:附23例报告
Pub Date : 2021-01-11 DOI: 10.19080/gjo.2021.23.556123
Oulghoul O
objectified Abstract Introduction: Temporal bone fractures often lead to loss of audio-vestibular function. Otic capsule violating fractures are associated with higher incidence of Sensorineural hearing loss than otic capsule sparing fractures. Material and methods: Prospective study conducted at the Mohammed VI University Hospital center of Marrakech, from January 2013 to June 2017, covering 23 cases of sensorineural hearing loss in the context of Temporal bone trauma. Results: The mean age was 31 years (4-56 years), with a clear male predominance (sex ratio 21/2). Clinical symptomatology was characterized by hearing loss in all our patients, otorrhagia in 20 cases, vertigo in 13 cases, facial paralysis in 10 cases, and otoliquorrhea in 5 cases. 96% of patients presented with labyrinthine fractures. Two cases of pneumolabyrinth and one case of bilateral temporal bone fracture were noted. The audiometry showed sensorineural hearing loss in 9 cases and mixed in 14 cases. In one case the hearing loss was bilateral with severe sensorineural hearing loss on one side and moderate on the other side. Conclusion: Temporal bone fracture is one of the most common traumatic injuries that can cause loss of auditory and vestibular function. The diagnosis must be made within a few hours after the trauma, as the auditory prognosis depends on the earliness of the management. Auditory sequelae can go as far as complete hearing loss, on the affected side.
摘要简介:颞骨骨折常导致听庭功能丧失。耳囊侵犯性骨折与耳囊保留性骨折相比,感音神经性听力损失的发生率更高。材料和方法:2013年1月至2017年6月在马拉喀什穆罕默德六世大学医院中心进行的前瞻性研究,涵盖23例颞骨创伤背景下的感音神经性听力损失。结果:平均年龄31岁(4 ~ 56岁),男性占明显优势(性别比21.5)。临床症状表现为听力丧失,耳出血20例,眩晕13例,面瘫10例,耳漏5例。96%的患者表现为迷路骨折。其中2例为气腹畸形,1例为双侧颞骨骨折。听力测定显示感音神经性听力损失9例,混合性听力损失14例。其中一例为双侧听力损失,一侧为重度感音神经性听力损失,另一侧为中度。结论:颞骨骨折是最常见的外伤性损伤之一,可导致听觉和前庭功能丧失。诊断必须在创伤后几个小时内作出,因为听觉预后取决于早期的处理。在受影响的一方,听觉后遗症可以达到完全听力丧失。
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引用次数: 0
Treatment Refractory Hypothyroidism Requiring High Dose Thyroxin Replacement 治疗需要大剂量甲状腺素替代的难治性甲状腺功能减退症
Pub Date : 2021-01-11 DOI: 10.19080/gjo.2021.23.556124
F. Afsana
causes of refractory hypothyroidism and approach for its diagnosis and management. Abstract A group of hypothyroid patients fails to achieve euthyroidism despite high doses of levothyroxine. These patients are designated as treatment refractory hypothyroidism. The prevalence of treatment-refractory hypothyroidism is not established. Noncompliance is one of the major issues in such cases .Other than noncompliance; impaired absorption due to gastrointestinal disease is a possibility. To achieve the target TSH or euthyroidism commonly the dose of levothyroxine is gradually increased but it may increase few adverse outcome, cost of investigation, follow up and treatment. Suspected patients should undergo a systematic approach for evaluation and management of this condition. In such a situation, there is a need to search for causes of decreased absorption of thyroxine or increased demand for thyroxine .This evaluation may help to reveal few underlying diseases and management of that disease may help to cure the refractoriness of levothyroxine replacement. An alternative formulation of levothyroxine may be prescribed to overcome the situation before going for detailed investigation. This article is emphasizing the diagnostic approach and management plan of such cases of treatment refractory hypothyroidism. intolerance, atrophic biliary pancreatic diversion, irritable bowel
难治性甲状腺功能减退症的病因及诊治方法。一组甲状腺功能减退患者,尽管高剂量左甲状腺素仍未能达到甲状腺功能亢进。这些患者被指定为治疗顽固性甲状腺功能减退。难治性甲状腺功能减退症的患病率尚未确定。在这种情况下,不遵守规定是主要问题之一。可能是胃肠道疾病导致的吸收障碍。为了达到TSH或甲状腺功能亢进的目标,左旋甲状腺素的剂量通常是逐渐增加的,但它可能增加一些不良反应,调查,随访和治疗的费用。疑似患者应接受系统的评估和治疗方法。在这种情况下,有必要寻找甲状腺素吸收减少或对甲状腺素需求增加的原因,这种评估可能有助于揭示一些潜在疾病和对该疾病的管理可能有助于治愈左旋甲状腺素替代的难治性。在进行详细调查之前,可能会规定左甲状腺素的替代配方来克服这种情况。本文就这类难治性甲状腺功能减退症的诊断方法及治疗方案作一综述。不耐受,胆胰分流萎缩,肠易激
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引用次数: 0
A Rare Cause of Vertigo- Case Report and Review of Literature 一种罕见的眩晕病因——病例报告及文献复习
Pub Date : 2020-12-01 DOI: 10.19080/gjo.2020.23.556121
P. Sabharisan
Presence of air within the labyrinth constitutes the term Pneumo-labyrinth. Pneumo-labyrinth may be associated with perilymph fistula. Most commonly trauma involving the otic capsule is associated with pneumolabyrinth. Depending on the location of the air bubble within the inner ear pneumolabyrinth can be subdivided into pneumocochlea and pneumovestibule, in which air is present in the cochlea and vestibule respectively [1]. In this case report we discuss a. regarding a case of vertigo b. management of pneumo-labyrinth and
迷宫内空气的存在构成术语气迷宫。肺迷路可能与淋巴管周围瘘管有关。最常见的涉及耳膜的创伤与气迷宫有关。根据内耳气通道内气泡的位置可分为气耳蜗和气前庭,其中空气分别存在于耳蜗和前庭中[1]。在这个病例报告中,我们讨论a.关于一例眩晕b.气迷路的处理和
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引用次数: 1
Weaning of Mechanically Ventilated Patients with COVID-19: Value of Modified Burns Wean Assessment Program Scores COVID-19机械通气患者的脱机:改良烧伤脱机评估程序评分的价值
Pub Date : 2020-12-01 DOI: 10.19080/gjo.2020.23.556122
M. Sherif
Background: Most patients with acute respiratory distress syndrome (ARDS) due to COVID-19 warrant intubation and mechanical ventilation (MV). Methods : As COVID-19 is a relatively new disease to us, with distinct clinical and pathophysiologic features and with massive burden on the health care facilities, particularly the intensive care units (ICUs), it is wise to think in using tools that are feasible, easy and save time and money. Previous studies showed that modified Burns wean assessment program (mBWAP) is a good predictor of weaning success. Results: mBWAP proved useful as a good predictor of successful weaning and extubation in patients requiring long-term MV longer than 21 days, as well as in patients with respiratory disorders admitted to the respiratory ICU. Conclusion: Previous data for mBWAP are encouraging and deserve utilizing it as a predictor tool for weaning from MV in patients with COVID-19. Further prospective studies are warranted.
背景:大多数COVID-19急性呼吸窘迫综合征(ARDS)患者需要气管插管和机械通气(MV)。方法:COVID-19对我们来说是一种相对较新的疾病,具有明显的临床和病理生理特征,给医疗机构,特别是重症监护病房(icu)带来了巨大的负担,应考虑使用可行、简便、节省时间和金钱的工具。先前的研究表明,改良的伯恩斯断奶评估程序(mBWAP)是一个很好的预测断奶成功的指标。结果:mBWAP被证明是需要超过21天的长期MV的患者成功脱机和拔管的良好预测指标,以及呼吸系统ICU住院的呼吸系统疾病患者。结论:mBWAP的既往数据令人鼓舞,值得将其作为COVID-19患者脱离MV的预测工具。进一步的前瞻性研究是必要的。
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引用次数: 0
Stacked coins ingestion and double rim sign on x-ray: A case report and review of literature 叠硬币摄入及x线双边缘征1例报告及文献复习
Pub Date : 2020-11-16 DOI: 10.19080/gjo.2020.23.556120
A. AhmadM.
Young children are known for their curious ways of exploring their surroundings. As a normal part of their development, they use all senses to familiarize themselves with new objects. Every new texture, smell, color, or taste will naturally attract a child and entice them to further explore. This instinctive behavior can however lead a child into harm’s way. The same curiosity that enhances their development can also pose a risk of accidental ingestion of foreign body [1,2]. These incidences become dangerous and complications vary in severity depending on the type of foreign body ingested, the duration until the time of presentation and site of impaction [1,2]. The most common objects accidently ingested by children are coins. However, many of these incidences are unwitnessed by the child’s guardians. An x-ray revealing a coin shaped object may in fact be something far more dangerous, such as a button battery. Button batteries are easily accessible to children as they are found in different toys and electronic devices. Due to their higher risk of causing complications, prompt intervention is required. A button battery appears as a circular, radiopaque object with a double halo or rim on an anteroposterior (AP) x-ray film [3,4]. However, these characteristics do not always confirm that the object is in fact a button battery. In our case, we are going to show that sometimes the double rim seen on an x-ray can be attributed to other types of ingested foreign bodies.
小孩子以好奇的方式探索周围的环境而闻名。作为他们发展的正常部分,他们使用所有的感官来熟悉新的物体。每一种新的质地、气味、颜色或味道都会自然而然地吸引孩子,并诱使他们进一步探索。然而,这种本能的行为可能会导致孩子受到伤害。同样的好奇心促进了它们的发育,也可能带来意外摄入异物的风险[1,2]。这些事件变得很危险,并发症的严重程度取决于摄入的异物类型、到出现时间的持续时间和嵌塞的部位[1,2]。儿童误食的最常见的物品是硬币。然而,这些事件中有许多是儿童的监护人没有目睹的。x光显示硬币形状的物体实际上可能是更危险的东西,比如纽扣电池。纽扣电池很容易被孩子们接触到,因为它们存在于不同的玩具和电子设备中。由于其引起并发症的风险较高,需要及时干预。纽扣电池在正位(AP) x射线胶片上呈现为圆形,不透射线的物体,具有双晕或边缘[3,4]。然而,这些特征并不总是能证实该物体实际上是一个纽扣电池。在我们的病例中,我们要说明的是,有时在x射线上看到的双边缘可以归因于其他类型的摄入异物。
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引用次数: 0
Dental Stem Cells- Potential for Tooth Regeneration 牙齿干细胞-牙齿再生的潜力
Pub Date : 2020-11-02 DOI: 10.19080/gjo.2020.23.556119
D. Ruby
Dental Stem cells are undifferentiated cells isolated from tooth and associated structures. Dental stem cells can be easily obtained from both adult and deciduous teeth, the periodontal ligament, the apical papilla and the dental follicle. Their subsequent differentiation can be utilized to replace the lost tooth structures. Here we aim to highlight potential of dental stem cells from varied origin for tooth regeneration. Several studies have demonstrated tooth tissue regeneration. Application of recent 3D bioprinting technology has further enhanced probability of accurate tooth tissue regeneration. However complete tooth regeneration is still a future thing.
牙干细胞是从牙齿及其相关结构中分离出来的未分化细胞。牙干细胞可以从成人牙和乳牙、牙周韧带、牙尖乳头和牙毛囊中轻易获得。它们随后的分化可以用来代替失去的牙齿结构。在这里,我们的目的是强调来自不同来源的牙干细胞在牙齿再生方面的潜力。几项研究证实了牙齿组织再生。近期生物3D打印技术的应用,进一步提高了牙齿组织精确再生的可能性。然而,完全的牙齿再生仍然是未来的事情。
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引用次数: 0
Oxidative Stress, Sensorineural Deafness Linked to Advancing Age - Presbycusis: Systematic Review 氧化应激、感音神经性耳聋与老年-老年性耳聋相关:系统综述
Pub Date : 2020-10-13 DOI: 10.19080/gjo.2020.23.556118
Aliocha Nkodila Natuhoyila
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引用次数: 0
Decision making in Resection of Oral Cancer: How to go about it 口腔癌切除术的决策:如何进行
Pub Date : 2020-09-23 DOI: 10.19080/gjo.2020.23.556114
Garima Rawat
Oral cancer is a global health problem with growing incidence and mortality rates. As highlighted by International Agency for Research on Cancer and World Health Organization on 2014, the early diagnosis of oral cancer reduces morbidity and mortality rates. The most accepted mode of initial definitive treatment for most oral cancers is surgical management. Various factors related to the primary Tumour and the patient affect choice of treatment. Primary site, location, size, proximity to bone, and depth of infiltration are factors which influence a particular surgical approach. Tumour’ s that approach or involve the mandible require specific understanding of the mechanism of bone involvement. Over time the role of surgery in primary squamous cell carcinomas in other sites in the head and neck has evolved with integration of multidisciplinary treatment approaches employing chemotherapy and radiotherapy either sequentially or concurrently. In this article, we throw light on the numerous component that influence the decision making of the surgeon before surgical resection in oral cancer.
口腔癌是一个发病率和死亡率不断上升的全球性健康问题。正如国际癌症研究机构和世界卫生组织2014年所强调的那样,口腔癌的早期诊断可降低发病率和死亡率。对于大多数口腔癌,最普遍接受的初步确定治疗模式是手术治疗。与原发肿瘤和患者有关的各种因素影响治疗的选择。原发部位、位置、大小、与骨的接近程度和浸润深度是影响特定手术入路的因素。对于接近或涉及下颌骨的肿瘤,需要对骨骼受累的机制有具体的了解。随着时间的推移,手术在头颈部其他部位原发性鳞状细胞癌中的作用随着多学科治疗方法的整合而发展,化疗和放疗可以先后或同时进行。在这篇文章中,我们阐明了影响口腔癌手术切除前外科医生决策的众多因素。
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引用次数: 0
Olfactory Dysfunction in Covid-19 Patients, The Current Evidence and Literature Review Covid-19患者的嗅觉功能障碍,当前证据和文献综述
Pub Date : 2020-09-03 DOI: 10.19080/gjo.2020.23.556112
Ali Almomen
Background: Osteoma, fibrous, dysplasia and ossifying fibroma are fibro-osseus lesions that can occur in the paranasal sinuses, management of these lesions can be technically challenging due to proximity to the orbit and skull base, with the advancement in endoscopic endonasal surgery and development of technologies such as image guidance can improve the safety of endoscopic removal and improve its safety. Illustrative cases : Three cases of fibro-ossuoes lesions are presented in this study an adult female with left frontoethmoidal osteoma, an adult male with left ethmoid fibrous dysplasia, both of whom have been treated with pure endonasal endoscopic approach with image guidance, the third case is a male child with juvenile ossifying fibroma, he was treated initially with the endoscopic approach with image guidance, but had a skull base recurrence 6 months later which was removed with an open craniotomy approach. Conclusion: Image guidance is a valuable tool in improving safety and efficiency of endoscopic sinus surgery particularly in challenging cases such as fibro-osseus lesions with proximity to the skull base and orbit.
背景:骨瘤、纤维性纤维瘤、发育不良纤维瘤和骨化性纤维瘤是可发生在鼻窦炎的纤维-骨性病变,由于靠近眼眶和颅底,这些病变的治疗在技术上具有挑战性,随着鼻内窥镜手术的进步和图像引导等技术的发展,可以提高内镜切除的安全性,提高其安全性。说明性案例:本研究报告3例纤维-骨骨病变,1例成年女性左侧额筛骨瘤,1例成年男性左侧筛纤维发育不良,均采用单纯内镜下图像引导入路治疗,第三例为男童幼年骨化纤维瘤,最初采用内镜下图像引导入路治疗,6个月后颅底复发,开颅手术切除。结论:图像引导是提高鼻窦内窥镜手术安全性和效率的重要工具,特别是在接近颅底和眼眶的纤维骨性病变等具有挑战性的病例中。
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引用次数: 0
期刊
Global Journal of Otolaryngology
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