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SIRT1 mediates nutritional regulation of SREBP-1c-driven hepatic PNPLA3 transcription via modulation of H3k9 acetylation SIRT1通过调节H3k9乙酰化介导SREBP-1c驱动的肝脏PNPLA3转录的营养调节
IF 1.7 4区 医学 Q2 GENETICS & HEREDITY
Genes and Environment
Pub Date : 2022-05-27 DOI: 10.1186/s41021-022-00246-1
Xiao Xu, Xiaojie Deng, Yun-Ting Chen, Wen Xu, Fen Xu, Hua Liang
{"title":"SIRT1 mediates nutritional regulation of SREBP-1c-driven hepatic PNPLA3 transcription via modulation of H3k9 acetylation","authors":"Xiao Xu, Xiaojie Deng, Yun-Ting Chen, Wen Xu, Fen Xu, Hua Liang","doi":"10.1186/s41021-022-00246-1","DOIUrl":"https://doi.org/10.1186/s41021-022-00246-1","url":null,"abstract":"","PeriodicalId":12709,"journal":{"name":"Genes and Environment","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48160987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China 滇东煤产区肺癌组织表皮生长因子受体基因G719X和S768I复合双突变的独特性
IF 1.7 4区 医学 Q2 GENETICS & HEREDITY
Genes and Environment
Pub Date : 2022-05-23 DOI: 10.1186/s41021-022-00248-z
Jun-ling Wang, Yuxia Fu, Yanguo Gao, Xiu-Ping Li, Qian Xiong, Rui Li, B. Hou, Ruo-Shan Huang, Jun-feng Wang, Jian-Kun Zhang, Jiajun Lv, Chao-Hua Zhang, Hong-Wei Li
{"title":"Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China","authors":"Jun-ling Wang, Yuxia Fu, Yanguo Gao, Xiu-Ping Li, Qian Xiong, Rui Li, B. Hou, Ruo-Shan Huang, Jun-feng Wang, Jian-Kun Zhang, Jiajun Lv, Chao-Hua Zhang, Hong-Wei Li","doi":"10.1186/s41021-022-00248-z","DOIUrl":"https://doi.org/10.1186/s41021-022-00248-z","url":null,"abstract":"","PeriodicalId":12709,"journal":{"name":"Genes and Environment","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46236328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
NEAT1 can be a diagnostic biomarker in the breast cancer and gastric cancer patients by targeting XIST, hsa-miR-612, and MTRNR2L8: integrated RNA targetome interaction and experimental expression analysis NEAT1通过靶向XIST、hsa-miR-612和MTRNR2L8:整合RNA靶组相互作用和实验表达分析，可作为乳腺癌和胃癌患者的诊断性生物标志物
IF 1.7 4区 医学 Q2 GENETICS & HEREDITY
Genes and Environment
Pub Date : 2022-05-17 DOI: 10.1186/s41021-022-00244-3
M. Azadeh, A. Salehzadeh, K. Ghaedi, S. Talesh Sasani
{"title":"NEAT1 can be a diagnostic biomarker in the breast cancer and gastric cancer patients by targeting XIST, hsa-miR-612, and MTRNR2L8: integrated RNA targetome interaction and experimental expression analysis","authors":"M. Azadeh, A. Salehzadeh, K. Ghaedi, S. Talesh Sasani","doi":"10.1186/s41021-022-00244-3","DOIUrl":"https://doi.org/10.1186/s41021-022-00244-3","url":null,"abstract":"","PeriodicalId":12709,"journal":{"name":"Genes and Environment","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44927694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Time-course changes in DNA damage of corneal epithelial cells in rabbits following ocular instillation with genotoxic compounds 家兔眼内灌注基因毒性化合物后角膜上皮细胞DNA损伤的时间变化
IF 1.7 4区 医学 Q2 GENETICS & HEREDITY
Genes and Environment
Pub Date : 2022-05-09 DOI: 10.1186/s41021-022-00243-4
Haruna Tahara, Yoshinori Yamagiwa, Yu Haranosono, M. Kurata
{"title":"Time-course changes in DNA damage of corneal epithelial cells in rabbits following ocular instillation with genotoxic compounds","authors":"Haruna Tahara, Yoshinori Yamagiwa, Yu Haranosono, M. Kurata","doi":"10.1186/s41021-022-00243-4","DOIUrl":"https://doi.org/10.1186/s41021-022-00243-4","url":null,"abstract":"","PeriodicalId":12709,"journal":{"name":"Genes and Environment","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47492518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copper-mediated DNA damage caused by purpurin, a natural anthraquinone 天然蒽醌嘌呤引起铜介导的DNA损伤
IF 1.7 4区 医学 Q2 GENETICS & HEREDITY
Genes and Environment
Pub Date : 2022-05-09 DOI: 10.1186/s41021-022-00245-2
Hatasu Kobayashi, Yurie Mori, R. Iwasa, Yuichiro Hirao, Shinya Kato, S. Kawanishi, M. Murata, S. Oikawa
{"title":"Copper-mediated DNA damage caused by purpurin, a natural anthraquinone","authors":"Hatasu Kobayashi, Yurie Mori, R. Iwasa, Yuichiro Hirao, Shinya Kato, S. Kawanishi, M. Murata, S. Oikawa","doi":"10.1186/s41021-022-00245-2","DOIUrl":"https://doi.org/10.1186/s41021-022-00245-2","url":null,"abstract":"","PeriodicalId":12709,"journal":{"name":"Genes and Environment","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42593879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Opinion: regulatory genotoxicity: past, present and future 意见：调节性遗传毒性：过去、现在和未来
IF 1.7 4区 医学 Q2 GENETICS & HEREDITY
Genes and Environment
Pub Date : 2022-04-22 DOI: 10.1186/s41021-022-00242-5
M. Hayashi
{"title":"Opinion: regulatory genotoxicity: past, present and future","authors":"M. Hayashi","doi":"10.1186/s41021-022-00242-5","DOIUrl":"https://doi.org/10.1186/s41021-022-00242-5","url":null,"abstract":"","PeriodicalId":12709,"journal":{"name":"Genes and Environment","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44216709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Evaluation of a 4-day repeated-dose micronucleus test in rat glandular stomach and colon using aneugens and non-genotoxic non-carcinogens 大鼠腺胃和结肠4天重复剂量微核试验的评价
IF 1.7 4区 医学 Q2 GENETICS & HEREDITY
Genes and Environment
Pub Date : 2022-04-11 DOI: 10.1186/s41021-022-00241-6
Emiko Okada, Yohei Fujiishi, K. Narumi, W. Ohyama
{"title":"Evaluation of a 4-day repeated-dose micronucleus test in rat glandular stomach and colon using aneugens and non-genotoxic non-carcinogens","authors":"Emiko Okada, Yohei Fujiishi, K. Narumi, W. Ohyama","doi":"10.1186/s41021-022-00241-6","DOIUrl":"https://doi.org/10.1186/s41021-022-00241-6","url":null,"abstract":"","PeriodicalId":12709,"journal":{"name":"Genes and Environment","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44007439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
o-Aminoazotoluene, 7,12-dimethylbenz[a]anthracene, and N-ethyl-N-nitrosourea, which are mutagenic but not carcinogenic in the colon, rapidly induce colonic tumors in mice with dextran sulfate sodium-induced colitis 邻氨基偶氮甲苯、7,12-二甲基苯并[a]蒽和N-乙基-N-亚硝基脲对结肠具有诱变性但不致癌，可在右旋糖酐硫酸钠诱导的结肠炎小鼠中快速诱导结肠肿瘤
IF 1.7 4区 医学 Q2 GENETICS & HEREDITY
Genes and Environment
Pub Date : 2022-03-29 DOI: 10.1186/s41021-022-00240-7
A. Hakura, Naoki Koyama, Yuki Seki, J. Sonoda, S. Asakura
{"title":"o-Aminoazotoluene, 7,12-dimethylbenz[a]anthracene, and N-ethyl-N-nitrosourea, which are mutagenic but not carcinogenic in the colon, rapidly induce colonic tumors in mice with dextran sulfate sodium-induced colitis","authors":"A. Hakura, Naoki Koyama, Yuki Seki, J. Sonoda, S. Asakura","doi":"10.1186/s41021-022-00240-7","DOIUrl":"https://doi.org/10.1186/s41021-022-00240-7","url":null,"abstract":"","PeriodicalId":12709,"journal":{"name":"Genes and Environment","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47996388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A local QSAR model based on the stability of nitrenium ions to support the ICH M7 expert review on the mutagenicity of primary aromatic amines. 基于氮离子稳定性的局部QSAR模型支持ICH M7专家对伯芳烃胺致突变性的评审。
IF 1.7 4区 医学 Q2 GENETICS & HEREDITY
Genes and Environment
Pub Date : 2022-03-21 DOI: 10.1186/s41021-022-00238-1
Ayaka Furukawa, Satoshi Ono, Katsuya Yamada, Nao Torimoto, Mahoko Asayama, Shigeharu Muto

Background: Aromatic amines, often used as intermediates for pharmaceutical synthesis, may be mutagenic and therefore pose a challenge as metabolites or impurities in drug development. However, predicting the mutagenicity of aromatic amines using commercially available, quantitative structure-activity relationship (QSAR) tools is difficult and often requires expert review. In this study, we developed a shareable QSAR tool based on nitrenium ion stability.

Results: The evaluation using in-house aromatic amine intermediates revealed that our model has prediction accuracy of aromatic amine mutagenicity comparable to that of commercial QSAR tools. The effect of changing the number and position of substituents on the mutagenicity of aromatic amines was successfully explained by the change in the nitrenium ion stability. Furthermore, case studies showed that our QSAR tool can support the expert review with quantitative indicators.

Conclusions: This local QSAR tool will be useful as a quantitative support tool to explain the substituent effects on the mutagenicity of primary aromatic amines. By further refinement through method sharing and standardization, our tool can support the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) M7 expert review with quantitative indicators.

背景:芳香胺通常用作药物合成的中间体，可能具有诱变性，因此在药物开发中作为代谢物或杂质构成挑战。然而，使用市售的定量构效关系(QSAR)工具预测芳香胺的致突变性是困难的，通常需要专家审查。在这项研究中，我们开发了一个基于氮离子稳定性的共享QSAR工具。结果:使用内部芳香胺中间体的评估表明，我们的模型具有与商业QSAR工具相当的芳香胺突变性预测精度。取代基数目和位置的改变对芳香胺致突变性的影响成功地用氮离子稳定性的变化来解释。此外，案例研究表明，我们的QSAR工具可以支持定量指标的专家评审。结论:该局部QSAR工具可作为解释取代基对伯芳胺致突变性影响的定量支持工具。通过方法共享和标准化进一步完善，我们的工具可以支持国际人用药品技术要求协调委员会(ICH) M7定量指标专家审查。
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引用次数: 0
Associations of maternal exposure to fine particulate matter with preterm and early-term birth in high-risk pregnant women 高危孕妇暴露于细颗粒物与早产和早产的关系
IF 1.7 4区 医学 Q2 GENETICS & HEREDITY
Genes and Environment
Pub Date : 2022-03-15 DOI: 10.1186/s41021-022-00239-0
Kaixin Cao, Hongyan Jin, Haoxin Li, Mengmeng Tang, Jianhong Ge, Zekang Li, Xiaoyun Wang, Xuetao Wei
{"title":"Associations of maternal exposure to fine particulate matter with preterm and early-term birth in high-risk pregnant women","authors":"Kaixin Cao, Hongyan Jin, Haoxin Li, Mengmeng Tang, Jianhong Ge, Zekang Li, Xiaoyun Wang, Xuetao Wei","doi":"10.1186/s41021-022-00239-0","DOIUrl":"https://doi.org/10.1186/s41021-022-00239-0","url":null,"abstract":"","PeriodicalId":12709,"journal":{"name":"Genes and Environment","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45417347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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