Gaceta medica de Mexico最新文献

Introduction: LDL-cholesterol greater than 190 mg/dL indicates severe hypercholesterolemia (HS) of monogenic and/or polygenic origin. Genetic risk scores (GRS) evaluate potential polygenic causes.

Objective: we applied a GRS of 6-SNP (GRS-6) in HS individuals.

Material and methods: 69 subjects from the Familial Hypercholesterolemia (HF) Detection registry in Argentina (Da Vinci).

Results: with 44 individuals with HF-phenotype, not carriers of genetic variants that indicate a monogenic origin (HF/M-) and 26 controls, the GRS-6 cut-off value was established, > 0.76, sensitivity 0.59, specificity 0.69. 15/44(34 %) HF/M- presented GRS-6+. The mean GRS-6 values in HF/M-, HF/M+ and controls were 0.72 ± 0.17, 0.66 ± 0.17, and 0.70 ± 0.13 respectively (p = 0.43). There were no significant differences in cholesterol values, or in the clinical score, between cases with positive vs negative GRS-6. The GRS-6 was positive in 32 % of the cases vs 20 % of the previously applied GRS-10 (p = 0.003), significantly increasing the detection of polygenic contribution.

Conclusions: We present an estimate of the first cut-off value for the GRS-6 in a Latin American population, and we conclude that the GRS-6 could contribute to the evaluation of the polygenic contribution in cases with severe hypercholesterolemia in our population in a similar way to that of other European populations.

Background: Assessment of muscle strength is of great interest for the study of age-associated pathologies, including frailty and sarcopenia. However, the cost of some of the equipment necessary for its evaluation could be prohibitive for its generalized use in some settings.

Objective: The purpose of the present study was to compare two handheld dynamometers to evaluate the measure of concordance between the measurements. Material and methods The study was conducted in the outpatient Geriatrics clinics where 120 community-dwelling participants aged 60 years and more were evaluated using two devices: the JAMAR^® Hydraulic Hand Dynamometer and the digital hand dynamometer CAMRY^® EH101.

Results: We observed a positive correlation between the two devices for dominant hand (DH) Pearson r 0.974 (p < 0.001) and a Spearman ρ 0.973 (p < 0.001) for non-dominant hand (NDH) Lin's coefficient for the DH was 0.98 (p < 0.001) and for the NDH 0.97 (p < 0.001). The intraclass correlation coefficient was 0.971 (95% CI, 0.95-0.97; p < 0.001) for DH and 0.975 (95% CI, 0.96-0.98; p < 0.001) for NDH.

Conclusions: In this study, the Camry dynamometer was observed to be reliable for measuring hand grip strength in community-dwelling people 60 years or older.

Background: Long COVID is defined as the persistence of COVID-19 symptoms four weeks after having undergone acute infection, according to the most recent CDC definition. It is estimated that there are 65 million people affected by this entity, although other figures speak of 200 million.

Objective: To characterize the population affected by long COVID in Mexico.

Material and methods: Patients older than 18 years who agreed to answer an online survey and who met the criteria for long COVID were included.

Results: Data from 203 subjects were included, with 138 (68.0%) being found to be females, and average age to be 41.8 years; 29.6% had severe disease, and 70.4%, mild to moderate disease; 89.7% had received prior COVID-19 vaccination: 6.9% had received one dose; 31.5%, two doses; and 51.2%, three or more doses. The main risk factors were diabetes, overweight or obesity, and hypertension. The most commonly reported symptom was fatigue, followed by other neuropsychiatric manifestations.

Conclusion: It is important for the population affected by long COVID to be characterized in order to generate diagnostic and treatment protocols.

In Mexico, it is not known which institutions use animals for scientific purposes. This work reports, based on data requested from the National Institute of Transparency, Access to Information and Protection of Personal Data (INAI), the types of institutions that use animals for research and how many of these have an ethics committee. Research centres, colleges, hospitals, national institutes, technical colleges, and public universities are the types of institutions that report using animals for experimentation. Only 54% of institutions have ethics committees. Mexican institutions from 2015 to 2021 used a total of 2,112,786 animals. Mammals are the most widely used animal group. The scientific purposes for using animals depend on the type of institution that uses them. In Mexico, it is necessary to update the regulations in order to regulate the use, protection and the care of laboratory animals.

Background: It has been documented that NSAIDs (nonsteroidal anti-inflammatory and antirheumatic drugs) reduce the effectiveness of some antihypertensive drugs.

Objective: Analyze the prescription of NSAID and the variables associated in outpatients with hypertension and explore some characteristics of the physicians.

Material and methods: Cross-sectional study, included patients with hypertension from the Family Medicine Unit No. 24 in Mante, Tamaulipas. From the patients, sociodemographic data, clinical history and pharmacological treatments were obtained. From the physicians, sociodemographic and academic information were collected.

Results: Mean age of the patients was 63 ± 11 years and 31.7% were prescribed NSAIDs. When compare exposed versus non-exposed to NSAIDs, being in uncontrolled high blood pressure, uncontrolled hypertension, multimorbidity and polypharmacy. The variables associated to the prescription of NSAIDs were: uncontrolled hypertension, multimorbidity and polypharmacy. The 56.7% of the physicians were women, 83.3% with experience >10 years and 33.3% with current certification by the Council in Family Medicine.

Conclusions: The inappropriate prescription of NSAIDs revealed the need to implement actions to mitigate the potential risk for the hypertension patients to present a complication.