Growth factors最新文献

英文中文

Transforming growth factor-β signalling pathway in tendon healing 转化生长因子-β信号通路在肌腱愈合中的作用

IF 1.8 4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Growth factors

Pub Date : 2022-06-16 DOI: 10.1080/08977194.2022.2082294

Yujie Li, Xinyue Liu, Xueli Liu, Yuanqiu Peng, Bin Zhu, Sheng Guo, Chenglong Wang, Dingxuan Wang, Sen Li

Abstract Transforming growth factor-β(TGF-β) plays an important but diverse role in tendon injuries, such as collagen synthesis, cell proliferation, cell differentiation, and cell adhesion, leading to tendon healing and tendon fibrosis. In the well-known canonical TGF-β signalling pathway, TGF-β activates Smad signalling through its two cell surface receptors, which leads to Smad-mediated transcriptional regulation and is also regulated by inhibitory Smads, forming a negative feedback regulatory pathway. In the context of the canonical TGF-β signalling mechanism mediated by Smad, the activated receptors also send signals through other signal transducers, which in the backdrop of TGF-β signaling are collectively known as non-Smad signalling pathways. Activated TGF-β binds to the receptor and acts through these signalling pathways. Understanding the mechanism of the TGF-β signalling pathway and its role in tendon repair is of great significance for targeting the TGF-β signalling pathway to accelerate tendon healing and reduce tendon fibrosis.

摘要转化生长因子-β（TGF-β）在肌腱损伤中发挥着重要而多样的作用，如胶原合成、细胞增殖、细胞分化和细胞粘附，导致肌腱愈合和肌腱纤维化。在众所周知的经典TGF-β信号通路中，TGF-β通过其两个细胞表面受体激活Smad信号传导，从而导致Smad介导的转录调节，并受到抑制性Smad的调节，形成负反馈调节通路。在Smad介导的典型TGF-β信号传导机制的背景下，被激活的受体也通过其他信号转导子发送信号，在TGF-β的信号传导背景下，这些信号转导子统称为非Smad信号传导途径。活化的TGF-β与受体结合，并通过这些信号通路发挥作用。了解TGF-β信号通路的机制及其在肌腱修复中的作用，对于靶向TGF-β的信号通路加速肌腱愈合、减少肌腱纤维化具有重要意义。

引用次数: 5

Impact of methionine restriction on muscle aerobic metabolism and hypertrophy in young and old mice on an obesogenic diet 蛋氨酸限制对肥胖饮食中年轻和老年小鼠肌肉有氧代谢和肥大的影响

IF 1.8 4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Growth factors

Pub Date : 2022-06-05 DOI: 10.1080/08977194.2022.2083963

Anandini Swaminathan, L. Cesanelli, T. Venckunas, H. Degens

Abstract Methionine restriction (MR) reduces inflammation and increases longevity. We studied the effects of MR (0.17% kCal methionine, 10% kCal fat) and MR + high-fat diet (HFD) (0.17% methionine, 45% kCal fat) and overload-induced hypertrophy on inflammation, angiogenesis and mitochondrial activity in the hind-limb muscle in 10- and 26-month-old male C57BL/6J mice. Plasma IL-6 concentrations were higher in old compared to young mice. M. plantaris hypertrophy was accompanied by increased p-Akt, without a significant change in Akt and VEGF levels. In young mice on a HFD or MR + HFD diet the SDH activity was higher than in those from mice on other diets, irrespective of overload. There were no significant differences in total NAD concentration in the m. gastrocnemius. MR enhanced the skeletal muscle hypertrophic response in old age that was accompanied with an increase in p-Akt without significant changes in muscle oxidative capacity, low-grade systemic inflammation, NAD, VEGF or Akt levels.

摘要蛋氨酸限制（MR）可减少炎症并延长寿命。我们研究了MR（0.17%kCal蛋氨酸，10%kCal脂肪）和MR的影响 + 高脂肪饮食（HFD）（0.17%蛋氨酸，45%kCal脂肪）和超负荷诱导的10和26个月大雄性C57BL/6J小鼠后肢肌肉炎症、血管生成和线粒体活性的肥大。老年小鼠的血浆IL-6浓度高于年轻小鼠。跖分枝杆菌肥大伴有p-Akt增加，而Akt和VEGF水平没有显著变化。在HFD或MR上的年轻小鼠中 + HFD饮食中的SDH活性高于其他饮食中的小鼠，无论过载如何。腓肠肌中总NAD浓度没有显著差异。MR增强了老年骨骼肌肥大反应，并伴有p-Akt的增加，而肌肉氧化能力、轻度全身炎症、NAD、VEGF或Akt水平没有显著变化。

引用次数: 1

The pheromone affects reproductive physiology and behavior by regulating hormone in juvenile mice. 信息素通过调节幼鼠体内的激素来影响生殖生理和行为。

IF 1.8 4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Growth factors

Pub Date : 2022-06-01 Epub Date: 2022-03-23 DOI: 10.1080/08977194.2022.2053527

Bing Hu, Zhongxiang Mo, Jianlin Jiang, Jinning Liang, Minlin Wei, Xiujuan Zhu, Yuan Liang, Yunhao Liu, Qiaojuan Huang, Yiqiang Ouyang, Junming Sun

Pheromones could promote hormone secretions and regulate sexual behavior. It was unclear whether multiparous pheromone could induce variations in puberty. The aim was to ascertain whether pheromone in urine of multiparous females induced central precocious puberty (CPP) in juvenile C57BL/6J females. The precocious puberty was examined by vaginal smear, lordosis reaction, HE stain, and ELISA analysis. Results suggested that the first vaginal opening and the first estrus were significantly earlier. The time interval of the first vaginal opening and estrus was significantly shortened. It was interesting that the first estrus was significantly correlated with the first vaginal opening and the time interval of the first estrus. In the first estrus, female lordosis reaction, the number of mature follicles, and the weight of the ovary and uterus significantly increased. The level of luteinizing hormones also significantly increased. Thus, multiparous pheromone can regulate sex hormone to induce CPP in juvenile C57BL/6J females.

信息素可以促进激素分泌，调节性行为。目前尚不清楚多胎信息素是否会引起青春期的变化。目的探讨多胎雌性尿费洛蒙是否会诱发C57BL/6J幼年雌性中枢性性早熟(CPP)。采用阴道涂片、前凸反应、HE染色、ELISA检测性早熟。结果表明，阴道第一次开口和第一次发情明显提前。第一次阴道开放与发情的时间间隔明显缩短。有趣的是，第一次发情与第一次阴道开口和第一次发情的时间间隔有显著的相关性。在第一次发情时，女性发生前凸反应，成熟卵泡数量增多，卵巢和子宫重量明显增加。黄体生成素水平也显著升高。由此可见，多产费洛蒙可以通过调节性激素诱导C57BL/6J幼年雌性CPP。

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引用次数: 2

miR-146a suppresses the expression of vascular endothelial growth factor and inflammatory responses in diabetic retinopathy miR-146a抑制糖尿病视网膜病变血管内皮生长因子的表达及炎症反应

IF 1.8 4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Growth factors

Pub Date : 2022-05-23 DOI: 10.1080/08977194.2022.2077732

Shichao Sun, Fu-Jun Wang, Yao Sun, L. Bai

Abstract This study was designed to explore the role of miR-146a in diabetic retinopathy (DR). 30 healthy control (HC), 50 patients with type 2 diabetes mellitus, and 48 DR patients were enrolled. Blood was collected and levels of miR-146a expression, vascular endothelial growth factor (VEGF), and three inflammatory cytokines (NF-κB, IL-1β, and TNF-α) were detected. Moreover, ARPE-19 cells were treated with miR-146a mimic or inhibitor in the presence of high glucose to evaluate its effect in vitro. DR patients had the lowest level of miR-146a and the highest level of VEGF as well as the most severe inflammation among the three groups. In addition, the miR-146a level was negatively correlated with the expression of VEGF and three inflammatory cytokines, respectively in DR patients. Moreover, VEGF expression was positively correlated with these three inflammatory cytokines in DR patients. In summary, miR-146a could inhibit VEGF expression and inflammation in DR.

本研究旨在探讨miR-146a在糖尿病视网膜病变(DR)中的作用。健康对照(HC) 30例，2型糖尿病患者50例，DR患者48例。采集血液，检测miR-146a、血管内皮生长因子(VEGF)和三种炎症因子(NF-κB、IL-1β、TNF-α)的表达水平。此外，在高糖存在的情况下，用miR-146a模拟物或抑制剂处理ARPE-19细胞，以评估其体外效果。DR患者miR-146a水平最低，VEGF水平最高，炎症反应最严重。此外，在DR患者中，miR-146a水平分别与VEGF和三种炎症细胞因子的表达呈负相关。此外，在DR患者中，VEGF的表达与这三种炎症因子呈正相关。综上所述，miR-146a可以抑制DR中VEGF的表达和炎症。

引用次数: 1

An appraisal of vascular endothelial growth factor (VEGF): the dynamic molecule of wound healing and its current clinical applications 血管内皮生长因子(VEGF):伤口愈合的动态分子及其目前的临床应用

IF 1.8 4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Growth factors

Pub Date : 2022-05-18 DOI: 10.1080/08977194.2022.2074843

A. Goswami, S. Basu, F. Huda, J. Pant, Amrita Ghosh Kar, T. Banerjee, V. Shukla

Abstract Angiogenesis is a critical step of wound healing, and its failure leads to chronic wounds. The idea of restoring blood flow to the damaged tissues by promoting neo-angiogenesis is lucrative and has been researched extensively. Vascular endothelial growth factor (VEGF), a key dynamic molecule of angiogenesis has been investigated for its functions. In this review, we aim to appraise its biology, the comprehensive role of this dynamic molecule in the wound healing process, and how this knowledge has been translated in clinical application in various types of wounds. Although, most laboratory research on the use of VEGF is promising, its clinical applications have not met great expectations. We discuss various lacunae that might exist in making its clinical application unsuccessful for commercial use, and provide insight to the foundation for future research.

血管生成是创面愈合的关键步骤，血管生成失败会导致慢性创面。通过促进新生血管生成来恢复血流到受损组织的想法是有利可图的，并得到了广泛的研究。血管内皮生长因子(Vascular endothelial growth factor, VEGF)作为血管生成的关键动态分子，其功能已被广泛研究。在这篇综述中，我们旨在评估其生物学，这种动态分子在伤口愈合过程中的综合作用，以及如何将这些知识转化为各种类型伤口的临床应用。尽管大多数关于VEGF使用的实验室研究都很有前景，但其临床应用并没有达到很大的期望。我们讨论了其临床应用不成功的各种可能存在的缺陷，并为未来的研究提供了基础。

引用次数: 13

The effects of CHF6467, a new mutated form of NGF, on cell models of human glioblastoma. A comparison with wild-type NGF 一种新的NGF突变形式CHF6467对人类胶质母细胞瘤细胞模型的影响。与野生型NGF的比较

IF 1.8 4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Growth factors

Pub Date : 2022-04-20 DOI: 10.1080/08977194.2022.2060095

L. Lisi, Gabriella Maria Pia Ciotti, Marta Chiavari, M. Martire, P. Navarra

Abstract CHF6467 is a mutated form of human recombinant nerve growth factor (NGF). The mutation selectively disrupts the binding of NGF to its p75NTR receptor while maintaining the affinity toward TrkA receptor. Because of such different profile of receptor interaction, CHF6467 maintains unaltered the neurotrophic and neuroprotective properties of wild-type NGF but shows reduced algogenic activity. In this study, we investigated the effects of CHF6467 on mortality, proliferation, cell-damage and migration in three human glioblastoma cell lines (U87MG, T98G, LN18), and in the rat astrocytoma C6 cells. Both CHF6467 and wild-type NGF, given in the range 1-50 ng/ml, did not modify cell proliferation, metabolism and migration, as well as the number of live/dead cells. The present in vitro data are predictive of a lack of tumorigenic activity by both wild-type NGF and CHF6467 on these cell types in vivo, and warrant for CHF6467 further clinical development.

摘要CHF6467是人类重组神经生长因子（NGF）的一种突变形式。该突变选择性地破坏NGF与其p75NTR受体的结合，同时保持对TrkA受体的亲和力。由于受体相互作用的这种不同特征，CHF6467保持野生型NGF的神经营养和神经保护特性不变，但显示出降低的致痛活性。在本研究中，我们研究了CHF6467对三种人胶质母细胞瘤细胞系（U87MG、T98G、LN18）和大鼠星形细胞瘤C6细胞的死亡率、增殖、细胞损伤和迁移的影响。CHF6467和野生型NGF都在1-50范围内 ng/ml，不会改变细胞增殖、代谢和迁移，以及活/死细胞的数量。目前的体外数据预测了野生型NGF和CHF6467在体内对这些细胞类型缺乏致瘤活性，并保证了CHF6 467的进一步临床开发。

引用次数: 2

The roles of epidermal growth factor receptor in viral infections 表皮生长因子受体在病毒感染中的作用

IF 1.8 4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Growth factors

Pub Date : 2022-04-19 DOI: 10.1080/08977194.2022.2063123

K. M. Lai, Wai-Leng Lee

Abstract Viruses are intracellular pathogen that exploit host cellular machinery for their propagation. Extensive research on virus-host interaction have shed light on an alternative antiviral strategy that targets host cell factors. Epidermal growth factor receptor (EGFR) is a versatile signal transducer that is involved in a range of cellular processes. Numerous studies have revealed how viruses exploit the function of EGFR in different stages of viral life cycle. In general, viruses attach onto the host cell surface and interacts with EGFR to facilitate viral entry, viral replication and spread as well as evasion from host immunosurveillance. Moreover, virus-induced activation of EGFR signalling is associated with mucin expression, tissue damage and carcinogenesis that contribute to serious complications. Herein, we review our current understanding of roles of EGFR in viral infection and its potential as therapeutic target in managing viral infection. We also discuss the available EGFR-targeted therapies and their limitations.

摘要病毒是利用宿主细胞机制进行繁殖的细胞内病原体。对病毒与宿主相互作用的广泛研究揭示了一种针对宿主细胞因子的替代抗病毒策略。表皮生长因子受体（EGFR）是一种多功能的信号转导子，参与一系列细胞过程。大量研究揭示了病毒如何在病毒生命周期的不同阶段利用EGFR的功能。通常，病毒附着在宿主细胞表面并与EGFR相互作用，以促进病毒进入、病毒复制和传播以及逃避宿主免疫监测。此外，病毒诱导的EGFR信号传导激活与粘蛋白表达、组织损伤和致癌有关，这些都会导致严重并发症。在此，我们回顾了我们目前对EGFR在病毒感染中的作用及其作为治疗靶点的潜力的理解。我们还讨论了可用的EGFR靶向疗法及其局限性。

引用次数: 1

Icariin attenuates renal fibrosis in vivo and in vitro by inhibiting the Notch2/Hes-1 pathway Icariin通过抑制Notch2/Hes-1通路减轻体内外肾纤维化

IF 1.8 4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Growth factors

Pub Date : 2022-04-15 DOI: 10.1080/08977194.2022.2060094

Qiaoqin Zhang, Lei Xie, Linqing Jiang, Jiaqing Ni, Wenke Han, Xiu-hua Mi, Ping Wang

Abstract Chinese herbs were widely proposed as a novel approach for renal fibrosis. Icariin has been reported to be involved in a variety of diseases. Unilateral ureteral obstruction (UUO) is a popular experimental model of renal injury, which is often used in the study of renal fibrosis. A UUO mouse model was successfully constructed, and tubular injury and renal fibrosis were observed. Icariin treatment attenuated tubular injury and renal fibrosis in UUO mice. In addition, treatment with Icariin reduced the fibronectin, type I collagen and α-SMA levels in UUO mice. Furthermore, in a transforming growth factor (TGF)-β1-induced renal fibrosis cell model, icariin treatment also decreased fibronectin, type I collagen and α-SMA expression. Icariin treatment also reversed the enhanced migration of TGF-β1-induced HK-2 cells. These data indicated that icariin suppressed renal fibrosis in vivo and in vitro. Additionally, icariin treatment suppressed the Notch2/Hes-1 pathway in UUO mice and TGF-β1-treated HK-2 cells. In summary, this study found that icariin reduced renal fibrosis in vivo and in vitro by inhibiting the Notch2/Hes-1 pathway, which might help to improve therapies for renal fibrosis.

摘要中草药被广泛认为是治疗肾纤维化的一种新方法。据报道，淫羊藿苷与多种疾病有关。单侧输尿管梗阻（UUO）是一种流行的肾损伤实验模型，常用于肾纤维化的研究。成功构建UUO小鼠模型，观察肾小管损伤和肾纤维化。Icariin治疗减轻UUO小鼠肾小管损伤和肾纤维化。此外，Icariin治疗降低了UUO小鼠的纤连蛋白、I型胶原和α-SMA水平。此外，在转化生长因子（TGF）-β1诱导的肾纤维化细胞模型中，icariin治疗还降低了纤连蛋白、I型胶原和α-SMA的表达。Icariin处理还逆转了TGF-β1诱导的HK-2细胞迁移增强。这些数据表明，icariin在体内和体外都能抑制肾纤维化。此外，icariin处理抑制了UUO小鼠和TGF-β1处理的HK-2细胞中的Notch2/Hes-1通路。总之，本研究发现，icariin通过抑制Notch2/Hes-1通路在体内和体外减少了肾纤维化，这可能有助于改善肾纤维化的治疗。

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引用次数: 2

Systematic training in master swimmer athletes increases serum insulin growth factor-1 and decreases myostatin and irisin levels 游泳健将的系统训练可提高血清胰岛素生长因子-1，降低肌肉生长抑制素和鸢尾素水平

IF 1.8 4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Growth factors

Pub Date : 2022-03-27 DOI: 10.1080/08977194.2022.2049262

V. Curiel-Cervantes, J. C. SOLÍS-SAINZ, M. Camacho-Barrón, A. Aguilar-Galarza, M. Valencia, M. Anaya-Loyola

Abstract During ageing, anabolic status is essential to prevent the decrease in quantity and quality of skeletal muscle mass (SMM). Exercise modulates endocrine markers of muscle status. We studied the differences of endocrine markers for muscle status in 62 non-sarcopenic Mexican swimmer adults aged 30–70 y/o, allocated into two groups: the systematic training (ST) group including master athletes with a physical activity level (PAL) >1.6, and the non-systematic training group (NST) composed by subjects with a PAL <1.5. Body composition, diet, biochemical and endocrine markers were analyzed. The ST group showed lower myostatin (MSTN) and irisin (IRI) levels, two strong regulators of SMM. The insulin growth factor-1 (IGF-1) was higher in the ST. This is consistent with most of the evidence in young athletes and resistance training programs, where IGF-1 and IRI seem to play a crucial role in maintaining anabolic status in master athletes.

在衰老过程中，合成代谢状态对于防止骨骼肌质量和数量的下降至关重要。运动调节肌肉状态的内分泌标记物。我们研究了62名年龄在30-70岁的非肌肉减少的墨西哥成年游泳运动员的肌肉状态内分泌标志物的差异，他们被分为两组:系统训练组(ST)包括身体活动水平(PAL) bbb1.6的运动员，以及非系统训练组(NST)由PAL <1.5的参与者组成。分析体成分、饮食、生化及内分泌指标。ST组表现出较低的肌生长抑制素(MSTN)和鸢尾素(IRI)水平，这是SMM的两种强调节因子。胰岛素生长因子-1 (IGF-1)在st中较高，这与大多数年轻运动员和阻力训练项目的证据一致，其中IGF-1和IRI似乎在维持高级运动员的合成代谢状态中起着至关重要的作用。

引用次数: 1

Quantile-specific heritability of serum growth factor concentrations. 血清生长因子浓度的分位数特异性遗传力。

IF 1.8 4区生物学 Q4 Biochemistry, Genetics and Molecular Biology

Growth factors

Pub Date : 2021-02-01 DOI: 10.1080/08977194.2022.2049261

Paul T Williams

Background: "Quantile-dependent expressivity" occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g. growth factor concentration) is high or low relative to its distribution.

Methods: Quantile-regression analysis was applied to family sets from the Framingham Heart Study to determine whether the heritability (h²) of vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), angiopoietin-2, and angiopoietin-2 (sTie-2) and VEGFR1 (sFlt-1) receptor concentrations were quantile-specific.

Results: Quantile-specific h² (±SE) increased with increasing percentiles of the age- and sex-adjusted VEGF (P_trend<10^-16), HGF (P_trend=0.0004), angiopoietin-2 (P_trend=0.0002), sTie-2 (P_trend=1.2 × 10^-5), and sFlt-1 distributions (P_trend=0.04).

Conclusion: Heritabilities of VEGF, HGF, angiopoitein-2, sTie-2 and sFlt-1 concentrations are quantile dependent. This may explain reported interactions of genetic loci (rs10738760, rs9472159, rs833061, rs3025039, rs2280789, rs1570360, rs2010963) with metabolic syndrome, diet, recurrent miscarriage, hepatocellular carcinoma, erysipelas, diabetic retinopathy, and bevacizumab treatment in their effect on VEGF concentrations.

背景:当基因变异的效应大小取决于表型(如生长因子浓度)相对于其分布是高还是低时，就会出现“分位数依赖性表达性”。方法:对弗雷明汉心脏研究的家族集进行分位数回归分析，以确定血管内皮生长因子(VEGF)、肝细胞生长因子(HGF)、血管生成素-2、血管生成素-2 (sTie-2)和VEGFR1 (sFlt-1)受体浓度的遗传力(h2)是否具有分位数特异性。结果:分位数特异性h2(±SE)随年龄和性别调整的VEGF (Ptrend-16)、HGF (Ptrend=0.0004)、血管生成素-2 (Ptrend=0.0002)、sTie-2 (Ptrend=1.2 × 10-5)和sFlt-1分布(Ptrend=0.04)的百分位数增加而增加。结论:VEGF、HGF、血管生成素-2、sTie-2和sFlt-1浓度的遗传度呈分位数依赖性。这可以解释已报道的基因位点(rs10738760、rs9472159、rs833061、rs3025039、rs2280789、rs1570360、rs2010963)与代谢综合征、饮食、复发性流产、肝细胞癌、丹毒、糖尿病视网膜病变和贝伐单抗治疗对VEGF浓度的影响之间的相互作用。

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