Pub Date : 2025-05-31DOI: 10.1016/j.gastrohep.2025.502498
Raúl Fernández García, Marta Lecuona Muñoz, Eduardo Redondo Cerezo, Maria Del Carmen Fernández Cano
{"title":"Double pylorus: An uncommon complication of peptic ulcer.","authors":"Raúl Fernández García, Marta Lecuona Muñoz, Eduardo Redondo Cerezo, Maria Del Carmen Fernández Cano","doi":"10.1016/j.gastrohep.2025.502498","DOIUrl":"10.1016/j.gastrohep.2025.502498","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502498"},"PeriodicalIF":2.2,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Managing Crohn's disease (CD) requires addressing factors beyond medical treatment alone, including health-related quality of life (HRQoL) and physical activity. This study aimed to understand the relationships between different intensities of physical activity, HRQoL, and inflammatory biomarkers in CD, considering sex as a factor that could influence these associations.
Patients and methods: A cross-sectional, observational study was conducted in 63 CD patients. Sociodemographic and clinical data, including C-reactive protein and fecal calprotectin determinations, were collected. The Inflammatory Bowel Disease Questionnaire (IBDQ-9) and the Global Physical Activity Questionnaire (GPAQ) were used to measure HRQoL and physical activity, respectively.
Results: Although females had similar inflammation levels to males, they engaged in less physical activity and reported lower HRQoL (especially in psychosocial wellbeing). Sedentary behavior and intense physical activity negatively impacted HRQoL in the overall sample and only in females. Higher fecal calprotectin concentrations were associated with poorer HRQoL in the total group and only in males. No correlation was found between inflammation and physical activity.
Conclusions: Sex differences influence the relationship between inflammation, physical activity, and HRQoL in CD. Given the greater impact of CD on emotional and social wellbeing in females, irrespective of physiological measures of inflammation, our findings support considering sex differences, which may inform more individualized approaches to improve HRQoL.
{"title":"Sex-based differences in the relationship between health-related quality of life, physical activity, and inflammatory markers in people with Crohn's disease.","authors":"Susana Herrero-Rodríguez, Leticia Martín-Cordero, Raquel Mayordomo, Isabel Gálvez, Eduardo Ortega","doi":"10.1016/j.gastrohep.2025.502494","DOIUrl":"10.1016/j.gastrohep.2025.502494","url":null,"abstract":"<p><strong>Objective: </strong>Managing Crohn's disease (CD) requires addressing factors beyond medical treatment alone, including health-related quality of life (HRQoL) and physical activity. This study aimed to understand the relationships between different intensities of physical activity, HRQoL, and inflammatory biomarkers in CD, considering sex as a factor that could influence these associations.</p><p><strong>Patients and methods: </strong>A cross-sectional, observational study was conducted in 63 CD patients. Sociodemographic and clinical data, including C-reactive protein and fecal calprotectin determinations, were collected. The Inflammatory Bowel Disease Questionnaire (IBDQ-9) and the Global Physical Activity Questionnaire (GPAQ) were used to measure HRQoL and physical activity, respectively.</p><p><strong>Results: </strong>Although females had similar inflammation levels to males, they engaged in less physical activity and reported lower HRQoL (especially in psychosocial wellbeing). Sedentary behavior and intense physical activity negatively impacted HRQoL in the overall sample and only in females. Higher fecal calprotectin concentrations were associated with poorer HRQoL in the total group and only in males. No correlation was found between inflammation and physical activity.</p><p><strong>Conclusions: </strong>Sex differences influence the relationship between inflammation, physical activity, and HRQoL in CD. Given the greater impact of CD on emotional and social wellbeing in females, irrespective of physiological measures of inflammation, our findings support considering sex differences, which may inform more individualized approaches to improve HRQoL.</p>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502494"},"PeriodicalIF":2.2,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-28DOI: 10.1016/j.gastrohep.2025.502457
Javier Crespo, Agustín Albillos, María Buti
{"title":"The Spanish National Strategic Plan for Hepatitis C: A legacy of success.","authors":"Javier Crespo, Agustín Albillos, María Buti","doi":"10.1016/j.gastrohep.2025.502457","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2025.502457","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502457"},"PeriodicalIF":2.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-21DOI: 10.1016/j.gastrohep.2025.502471
Liseth Rivero-Sánchez , Joaquín Castillo-Iturra , Ana García-Rodríguez , Beatriz García Zafra , Pilar Díez Redondo , Henar Núñez Rodríguez , Marta Ponce , Mileidis San Juan , Pilar Borque Barrera , Agustín Seoane , Marc Albert Carrasco , Diana Zaffalon , Carlos Guarner , Marianette Murzi , Rodrigo Jover , Lucía Medina-Prado , Kattalin Aspuru Rubio , Diana João Matias , Begoña González Suárez , Henry Córdova , Gloria Fernández-Esparrach
Background and aims
Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality. Colonoscopy is the diagnostic gold standard, although its performance in symptomatic patients is limited. During the COVID-19 pandemic, the AEG-SEED societies proposed a clinical prioritization system. The aim of this study was to validate its diagnostic performance in detecting clinically relevant lesions (CRLs), including CRC, and to compare it with the fecal immunochemical test (FIT).
Patients and methods
A national multicenter retrospective study was conducted in 12 Spanish hospitals. A total of 1078 adult patients with digestive symptoms attended between April and December 2020 were included. Colonoscopies were prospectively classified according to priority levels (P1, P2, P3).
Results
CRLs were identified in 18% of patients, including 36 cases of CRC (3%). The diagnostic yield was highest in P1 (PPV 27%, AUC 0.57 for CRLs; PPV 7%, AUC 0.64 for CRC), and decreased in P2 and P3. FIT was performed in 26% of patients based on the referring physician's clinical judgment, showing higher sensitivity and negative predictive value (NPV) for CRC (100%) and a higher AUC (0.69) compared to clinical criteria.
Conclusions
The AEG-SEED clinical criteria offer moderate value for prioritizing colonoscopies in the absence of FIT. However, FIT demonstrates superior diagnostic performance and should be systematically incorporated. The combination of symptoms improves accuracy compared to isolated symptoms.
{"title":"Colonoscopy in symptomatic patients: Validation of AEG-SEED prioritization criteria and added value of FIT. The endoprior study","authors":"Liseth Rivero-Sánchez , Joaquín Castillo-Iturra , Ana García-Rodríguez , Beatriz García Zafra , Pilar Díez Redondo , Henar Núñez Rodríguez , Marta Ponce , Mileidis San Juan , Pilar Borque Barrera , Agustín Seoane , Marc Albert Carrasco , Diana Zaffalon , Carlos Guarner , Marianette Murzi , Rodrigo Jover , Lucía Medina-Prado , Kattalin Aspuru Rubio , Diana João Matias , Begoña González Suárez , Henry Córdova , Gloria Fernández-Esparrach","doi":"10.1016/j.gastrohep.2025.502471","DOIUrl":"10.1016/j.gastrohep.2025.502471","url":null,"abstract":"<div><h3>Background and aims</h3><div>Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality. Colonoscopy is the diagnostic gold standard, although its performance in symptomatic patients is limited. During the COVID-19 pandemic, the AEG-SEED societies proposed a clinical prioritization system. The aim of this study was to validate its diagnostic performance in detecting clinically relevant lesions (CRLs), including CRC, and to compare it with the fecal immunochemical test (FIT).</div></div><div><h3>Patients and methods</h3><div>A national multicenter retrospective study was conducted in 12 Spanish hospitals. A total of 1078 adult patients with digestive symptoms attended between April and December 2020 were included. Colonoscopies were prospectively classified according to priority levels (P1, P2, P3).</div></div><div><h3>Results</h3><div>CRLs were identified in 18% of patients, including 36 cases of CRC (3%). The diagnostic yield was highest in P1 (PPV 27%, AUC 0.57 for CRLs; PPV 7%, AUC 0.64 for CRC), and decreased in P2 and P3. FIT was performed in 26% of patients based on the referring physician's clinical judgment, showing higher sensitivity and negative predictive value (NPV) for CRC (100%) and a higher AUC (0.69) compared to clinical criteria.</div></div><div><h3>Conclusions</h3><div>The AEG-SEED clinical criteria offer moderate value for prioritizing colonoscopies in the absence of FIT. However, FIT demonstrates superior diagnostic performance and should be systematically incorporated. The combination of symptoms improves accuracy compared to isolated symptoms.</div></div>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 9","pages":"Article 502471"},"PeriodicalIF":1.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-21DOI: 10.1016/j.gastrohep.2025.502470
Asunción Ojeda , Arantxa Gelabert , Virginia Hernández-Gea , Juan Carlos García-Pagán
Non-cirrhotic non tumoral portal vein thrombosis is an entity of low prevalence but with a potential risk of developing complications of portal hypertension, which has a significant prognostic impact on patients. In the absence of liver cirrhosis, it is essential to rule out other chronic liver disease as well as local factors and prothrombotic conditions. Therefore, a thorough workup should be initiated immediately. In acute thrombosis, anticoagulation is the main treatment to prevent progression of thrombosis and development of intestinal ischemia. In chronic forms, however, close follow-up is essential to prevent and treat complications of portal hypertension. For refractory complications of portal hypertension, endovascular recanalization techniques have promising results and are becoming increasingly important.
{"title":"Portal vein thrombosis in the absence of cirrhosis: Diagnostic and therapeutic approach in clinical practice","authors":"Asunción Ojeda , Arantxa Gelabert , Virginia Hernández-Gea , Juan Carlos García-Pagán","doi":"10.1016/j.gastrohep.2025.502470","DOIUrl":"10.1016/j.gastrohep.2025.502470","url":null,"abstract":"<div><div><span>Non-cirrhotic non tumoral portal vein thrombosis is an entity of low prevalence but with a potential risk of developing complications of </span>portal hypertension<span><span><span><span>, which has a significant prognostic impact on patients. In the absence of liver cirrhosis, it is essential to rule out other </span>chronic liver disease as well as local factors and prothrombotic conditions. Therefore, a thorough workup should be initiated immediately. In acute thrombosis, </span>anticoagulation is the main treatment to prevent progression of thrombosis and development of </span>intestinal ischemia<span>. In chronic forms, however, close follow-up is essential to prevent and treat complications of portal hypertension. For refractory complications of portal hypertension, endovascular recanalization techniques have promising results and are becoming increasingly important.</span></span></div></div>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 9","pages":"Article 502470"},"PeriodicalIF":1.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-18DOI: 10.1016/j.gastrohep.2025.502468
Joan Llach , Lilliam Flores , Ana de Hollanda , Alba Andreu , Eduard Espinet-Coll , Gherzon Casanova , Maria Isabel Olivé , Eva Rivas , Ainitze Ibarzabal , Javier Osorio , Josep Vidal , Francesc Balaguer , Maria Pellisé
{"title":"Transoral outlet reduction for dumping syndrome after gastric bypass: A case series","authors":"Joan Llach , Lilliam Flores , Ana de Hollanda , Alba Andreu , Eduard Espinet-Coll , Gherzon Casanova , Maria Isabel Olivé , Eva Rivas , Ainitze Ibarzabal , Javier Osorio , Josep Vidal , Francesc Balaguer , Maria Pellisé","doi":"10.1016/j.gastrohep.2025.502468","DOIUrl":"10.1016/j.gastrohep.2025.502468","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 9","pages":"Article 502468"},"PeriodicalIF":1.9,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-17DOI: 10.1016/j.gastrohep.2025.502465
Edward Sanchez-Haro , Laura Hernández Leon , José Troya , Sandra Vela , Ingrid Tapiolas , Eva Martínez-Cáceres , Pedro-Luis Fernandez , David Parés
Introduction
Traditionally, anorectal abscesses and anal fistulas have been considered to originate from a common site within the fistula tract (the intersphincteric space), according to the cryptoglandular hypothesis. Understanding the distribution of cells and inflammatory mediators in different parts of the anal fistula tract is of significant interest. This study aimed to analyze the inflammatory characteristics of anal fistula tract specimens.
Methods
An observational study was conducted on specimens retrieved from consecutive cases. We analyzed samples of chronic anorectal fistulas, which were topographically divided into three parts: superficial part (including the external fistula opening, close to the perianal skin), middle (including the intersphincteric space), and deep part (close to the anal canal, including the internal fistula opening). These samples were reviewed under microscopy to describe cell types using hematoxylin–eosin staining and the presence of pro-inflammatory cytokines TNF-alpha and IL-36 using immunohistochemical staining.
Results
Fistula tract samples were obtained surgically from 15 patients. No epithelial lining was observed in any part of the samples. We found a predominance of granulation tissue with chronic inflammatory components and no signs of acute inflammation, with no differences among the different parts of each sample studied. Immunohistochemistry revealed the presence of TNF-alpha throughout the fistulous tract, with an increasing trend towards the deep third (internal opening), although this was not statistically significant. In contrast, IL-36 was uniformly distributed across all three parts of the fistula tract.
Conclusions
There is no specific site within the anal fistula tract that shows distinct findings related to the inflammatory process.
{"title":"Histological features and inflammatory cytokine profiles in anal fistula: A prospective cohort study","authors":"Edward Sanchez-Haro , Laura Hernández Leon , José Troya , Sandra Vela , Ingrid Tapiolas , Eva Martínez-Cáceres , Pedro-Luis Fernandez , David Parés","doi":"10.1016/j.gastrohep.2025.502465","DOIUrl":"10.1016/j.gastrohep.2025.502465","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditionally, anorectal abscesses and anal fistulas have been considered to originate from a common site within the fistula tract (the intersphincteric space), according to the cryptoglandular hypothesis. Understanding the distribution of cells and inflammatory mediators in different parts of the anal fistula tract is of significant interest. This study aimed to analyze the inflammatory characteristics of anal fistula tract specimens.</div></div><div><h3>Methods</h3><div>An observational study was conducted on specimens retrieved from consecutive cases. We analyzed samples of chronic anorectal fistulas, which were topographically divided into three parts: superficial part (including the external fistula opening, close to the perianal skin), middle (including the intersphincteric space), and deep part (close to the anal canal, including the internal fistula opening). These samples were reviewed under microscopy to describe cell types using hematoxylin–eosin staining and the presence of pro-inflammatory cytokines TNF-alpha and IL-36 using immunohistochemical staining.</div></div><div><h3>Results</h3><div>Fistula tract samples were obtained surgically from 15 patients. No epithelial lining was observed in any part of the samples. We found a predominance of granulation tissue with chronic inflammatory components and no signs of acute inflammation, with no differences among the different parts of each sample studied. Immunohistochemistry revealed the presence of TNF-alpha throughout the fistulous tract, with an increasing trend towards the deep third (internal opening), although this was not statistically significant. In contrast, IL-36 was uniformly distributed across all three parts of the fistula tract.</div></div><div><h3>Conclusions</h3><div>There is no specific site within the anal fistula tract that shows distinct findings related to the inflammatory process.</div></div>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 9","pages":"Article 502465"},"PeriodicalIF":1.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-06DOI: 10.1016/j.gastrohep.2025.502459
Miriam Celada-Sendino, Margarita Fernández-de la Varga, Marta Álvarez-Posadilla, Adrián Huergo-Fernández
{"title":"Red yeast rice: From liver toxicity to liver transplantation","authors":"Miriam Celada-Sendino, Margarita Fernández-de la Varga, Marta Álvarez-Posadilla, Adrián Huergo-Fernández","doi":"10.1016/j.gastrohep.2025.502459","DOIUrl":"10.1016/j.gastrohep.2025.502459","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 9","pages":"Article 502459"},"PeriodicalIF":1.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-02DOI: 10.1016/j.gastrohep.2025.502458
María Ortiz de Solórzano Reig , Julia López de la Cruz , María Concepción Aso Gonzalvo , Antonio Aguilar Muñiz , Marta Latre Santos , Enrique Ceamanos Ibarra , María Escuín Sanmartín , Guillén Bernal Bandrés , Sergio García Mateo , Judith Millastre Bocos
{"title":"Hemorragia digestiva secundaria a pseudoaneurisma tras anticoagulación por trombosis esplácnica en pancreatitis aguda necrohemorrágica","authors":"María Ortiz de Solórzano Reig , Julia López de la Cruz , María Concepción Aso Gonzalvo , Antonio Aguilar Muñiz , Marta Latre Santos , Enrique Ceamanos Ibarra , María Escuín Sanmartín , Guillén Bernal Bandrés , Sergio García Mateo , Judith Millastre Bocos","doi":"10.1016/j.gastrohep.2025.502458","DOIUrl":"10.1016/j.gastrohep.2025.502458","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":"48 9","pages":"Article 502458"},"PeriodicalIF":1.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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