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Early endovascular approaches for treating acute mesenteric arterial occlusive disease in hemodialysis patients 治疗血液透析患者急性肠系膜动脉闭塞症的早期血管内方法。
IF 1.3 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-02-22 DOI: 10.1111/hdi.13139
Siyuan Qu, Rui Wen, Mingming Yan, Jiao Qin, Jiali Li

Background

Among hemodialysis patients, acute superior mesenteric artery (SMA) thrombosis a condition with a high mortality rate. Very few larger case series have been reported.

Method

We reviewed eight hemodialysis patients with diabetes mellitus and SMA thrombosis managed with endovascular therapy in our institution. Demographic, clinical, and radiological data were described. The patency of the SMA was assessed by computed tomography angiography (CTA) at one month after the endovascular procedure. At the last visit, clinical symptoms and check of mortality were recorded.

Results

Multidetector CTA scan revealed severe stenosis of SMA in 6 patients and SMA occlusion in the other two patients. The severe stenosis of SMA were verified by angiography. Balloon angioplasty without stenting was performed to obtain satisfactory patency of SMA. Seven of eight patients achieved resolution of abdominal pain after the endovascular procedure. One patient died of suspected intestinal necrosis after 6 days of balloon angioplasty. All seven surviving patients did not experience a recurrence of symptoms with a median follow-up of 2 years. No significant residual stenotic or occlusive lesions were noted in follow-up CTA at one month after the endovascular procedure.

Conclusion

SMA thrombosis should be systematically suspected in hemodialysis patients experiencing abdominal pain. Prompt diagnosis of SMA thrombosis as soon as possible and early endovascular therapy are required to obtain a favorable prognosis in the hemodialysis patient with SMA thrombosis.

背景:在血液透析患者中,急性肠系膜上动脉(SMA)血栓是一种死亡率很高的疾病。方法:我们回顾了 8 例患有糖尿病并合并 SMA 血栓的血液透析患者:方法:我们回顾了在本院接受血管内治疗的 8 名患有糖尿病和 SMA 血栓的血液透析患者。描述了人口统计学、临床和放射学数据。血管内治疗术后一个月,通过计算机断层扫描血管造影术(CTA)评估了 SMA 的通畅情况。最后一次就诊时,记录了临床症状并检查了死亡率:结果:多载体CTA扫描显示,6名患者的SMA严重狭窄,另外两名患者的SMA闭塞。血管造影验证了 SMA 的严重狭窄。为使 SMA 获得满意的通畅性,对患者进行了不带支架的球囊血管成形术。八名患者中有七名在血管内手术后缓解了腹痛。一名患者在接受球囊血管成形术 6 天后死于疑似肠坏死。所有七名幸存患者在中位两年的随访中均未再出现症状。血管内手术后一个月的随访CTA检查未发现明显的残余狭窄或闭塞病变:结论:出现腹痛的血液透析患者应系统地怀疑 SMA 血栓。结论:对于出现腹痛的血液透析患者,应系统地怀疑 SMA 血栓形成,尽快确诊 SMA 血栓形成并尽早进行血管内治疗,才能为 SMA 血栓形成的血液透析患者带来良好的预后。
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引用次数: 0
Acute upper limb ischemia caused by thrombus shedding during arteriovenous graft thrombolysis: A case report 动静脉移植溶栓过程中血栓脱落导致急性上肢缺血:病例报告。
IF 1.3 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-02-22 DOI: 10.1111/hdi.13135
Changli Sun, Ziming Wan, Qiquan Lai, Bo Tu, Bo Chen

Acute upper limb ischemia is a rare, potentially limb- or life-threatening vascular emergency that may lead to limb dysfunction or amputation. We present a patient undergoing maintenance hemodialysis who was hospitalized for arteriovenous graft thrombus complicated by acute upper limb ischemia arising from thrombus shedding to the fingertip arteries during thrombolysis. We successfully restored fingertip arterial patency, avoided amputation, and recovered the function of the arteriovenous graft by precise thrombolysis, anticoagulation, correction of arteriospasm, and percutaneous transluminal angioplasty. This case provides a basis for vascular access surgeons to treat acute upper limb ischemia caused by thromboembolism similarly.

急性上肢缺血是一种罕见的、可能危及肢体或生命的血管急症,可导致肢体功能障碍或截肢。我们为您介绍一位正在接受维持性血液透析的患者,她因动静脉移植血栓住院,在溶栓过程中血栓脱落至指尖动脉,并发急性上肢缺血。我们通过精确溶栓、抗凝、纠正动脉痉挛和经皮腔内血管成形术,成功恢复了指尖动脉的通畅,避免了截肢,并恢复了动静脉移植物的功能。该病例为血管通路外科医生以类似方法治疗血栓栓塞引起的急性上肢缺血提供了依据。
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引用次数: 0
Is hemodiafiltration superior to high-flow hemodialysis in reducing all-cause and cardiovascular mortality in kidney failure patients? A meta-analysis of randomized controlled trials 在降低肾衰竭患者的全因死亡率和心血管死亡率方面,血液滤过是否优于高流量血液透析?随机对照试验荟萃分析。
IF 1.3 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-02-18 DOI: 10.1111/hdi.13136
Paulo Roberto Bignardi, Vinicius Daher Alvares Delfino

Introduction

Hemodiafiltration (HDF) and high-flux hemodialysis (hf-HD) are different methods of kidney replacement therapy (KRT) used for the treatment of kidney failure patients. A debate has raged over the last decade about the survival benefit of patients with the use of HDF compared with hf-HD, but with divergent results from randomized controlled trials. Therefore, this study aimed to perform a meta-analysis to compare HDF and hf-HD regarding all-cause and cardiovascular mortality.

Methods

PubMed and Cochrane databases were searched until July 19, 2023, for randomized clinical trials comparing HDF and hf-HD in patients on maintenance dialysis. A meta-analysis was performed using Stata 16.1, applying fixed or random effect models according to the heterogeneity between studies.

Findings

Of the 496 studies found, five met the inclusion criteria. Compared with the hf-HD group, the risk ratio (RR) for all-cause mortality with HDF use was 0.76 (95% CI: 0.67–0.88, I2 = 0%). HDF was associated with lower cardiovascular mortality, although the sensitivity analysis showed that the result differed between scenarios. Subgroup analysis showed lower all-cause mortality among patients without diabetes in the HDF group compared with hf-HD (RR 0.66, 95% CI: 0.51–0.81, I2 = 0%), but not in diabetic patients (RR = 0.89, 95% CI: 0.65–1.12, I2 = 0.0%). A subgroup analysis considering convection volumes was not performed, but the studies with the highest weight in the meta-analysis described convection volume as more than 20 L/session.

Discussion

More clinical studies considering critical risk factors, such as advanced age and preexisting cardiovascular disease, are needed to confirm the supremacy of HDF over hf-HD on the survival of patients treated by these two forms of kidney replacement therapy.

导言:血液滤过(HDF)和高通量血液透析(hf-HD)是用于治疗肾衰竭患者的不同肾脏替代疗法(KRT)。在过去的十年中,关于使用高通量血液透析(HDF)和高通量血液透析(hf-HD)对患者的生存是否有益的争论一直没有停止过,但随机对照试验的结果却不尽相同。因此,本研究旨在进行一项荟萃分析,比较 HDF 和 hf-HD 在全因死亡率和心血管死亡率方面的差异:方法:在 2023 年 7 月 19 日前,在 PubMed 和 Cochrane 数据库中搜索了对维持性透析患者进行 HDF 和 hf-HD 比较的随机临床试验。使用Stata 16.1进行荟萃分析,根据研究之间的异质性采用固定或随机效应模型:在找到的 496 项研究中,有 5 项符合纳入标准。与 hf-HD 组相比,使用 HDF 的全因死亡率风险比 (RR) 为 0.76(95% CI:0.67-0.88,I2 = 0%)。HDF与心血管死亡率降低有关,但敏感性分析表明,不同方案的结果有所不同。亚组分析显示,与 hf-HD 相比,HDF 组无糖尿病患者的全因死亡率较低(RR 0.66,95% CI:0.51-0.81,I2 = 0%),但糖尿病患者的全因死亡率较低(RR = 0.89,95% CI:0.65-1.12,I2 = 0.0%)。没有进行考虑对流容量的亚组分析,但在荟萃分析中权重最高的研究将对流容量描述为 20 升/次以上:讨论:需要进行更多考虑高龄和原有心血管疾病等关键风险因素的临床研究,以证实在这两种肾脏替代疗法的患者生存率方面,HDF优于hf-HD。
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引用次数: 0
Success is just running out of mistakes: a lifelong quest to make hemodialysis simple, safe, and effective. Ash SR. Pittsburgh, PA: Dorrance Publishing; 2023 Ash SR.成功只是因为犯了错误:让血液透析变得简单、安全、有效的毕生追求。宾夕法尼亚州匹兹堡:Dorrance Publishing; 2023, 94 pp.ISBN: 979-8-8852-7146-2; eISBN: 979-8-8852-7873-7.
IF 1.3 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-02-18 DOI: 10.1111/hdi.13132
Fokko P. Wieringa
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引用次数: 0
Successful twin pregnancy in a woman undergoing alternate diurnal and nocturnal hemodialysis 一名交替接受日间和夜间血液透析的妇女成功怀上双胞胎。
IF 1.3 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-02-14 DOI: 10.1111/hdi.13134
Geoffroy Desbuissons, Liliane Ngango, Christophe Baudeau, Philippe Fournier

Although pregnancy has become more frequent in patients undergoing hemodialysis, it remains a relatively rare event and carries a high risk of complications for both the mother and the fetus. In parallel, multiple pregnancies are also associated with a high risk of complications for the mother and the fetus, even in healthy women. The presence of a twin pregnancy in a woman with chronic renal failure undergoing hemodialysis is an even rarer event and is considered a very high-risk situation. We describe the case of a 31-year-old hemodialysis patient who successfully gave birth to twins at 29 weeks after a period of alternate diurnal and nocturnal hemodialysis.

虽然血液透析患者怀孕的情况越来越多,但这仍然是一个相对罕见的情况,而且对母亲和胎儿来说都有很高的并发症风险。与此同时,多胎妊娠对母亲和胎儿的并发症风险也很高,即使是健康的妇女也是如此。在接受血液透析的慢性肾功能衰竭妇女中出现双胎妊娠的情况更为罕见,被认为是非常高危的情况。我们描述了一例 31 岁的血液透析患者,她在昼夜交替进行血液透析一段时间后,于 29 周时成功产下一对双胞胎。
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引用次数: 0
Longitudinal changes in diffusion tensor imaging in hemodialysis patients 血液透析患者弥散张量成像的纵向变化。
IF 1.3 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-02-13 DOI: 10.1111/hdi.13133
Wesley T. Richerson, Brian D. Schmit, Dawn F. Wolfgram

Introduction

Hemodialysis patients have increased white matter and gray matter pathology in the brain relative to controls based on MRI. Diffusion tensor imaging is useful in detecting differences between hemodialysis and controls but has not identified the expected longitudinal decline in hemodialysis patients. In this study we implemented specialized post-processing techniques to reduce noise to detect longitudinal changes in diffusion tensor imaging parameters and evaluated for any association with changes in cognition.

Methods

We collected anatomical and diffusion MRIs as well as cognitive testing from in-center hemodialysis patients at baseline and 1 year later. Gray matter thickness, white matter volume, and white matter diffusion tensor imaging parameters were measured to identify longitudinal changes. We analyzed the diffusion tensor imaging parameters by averaging the whole white matter and using a pothole analysis. Eighteen hemodialysis patients were included in the longitudinal analysis and 15 controls were used for the pothole analysis. We used the NIH Toolbox Cognition Battery to assess cognitive performance over the same time frame.

Findings

Over the course of a year on hemodialysis, we found a decrease in white matter fractional anisotropy across the entire white matter (p < 0.01), and an increase in the number of white matter fractional anisotropy voxels below pothole threshold (p = 0.03). We did not find any relationship between changes in whole brain structural parameters and cognitive performance.

Discussion

By employing noise reducing techniques, we were able to detect longitudinal changes in diffusion tensor imaging parameters in hemodialysis patients. The fractional anisotropy declines over the year indicate significant decreases in white matter health. However, we did not find that declines in fractional anisotropy was associated with declines in cognitive performance.

简介:根据核磁共振成像,血液透析患者的大脑白质和灰质病变相对于对照组有所增加。弥散张量成像可用于检测血液透析患者与对照组之间的差异,但并不能确定血液透析患者的预期纵向下降。在这项研究中,我们采用了专门的后处理技术来降低噪音,以检测弥散张量成像参数的纵向变化,并评估其与认知变化之间的关联:我们收集了中心内血液透析患者基线和一年后的解剖和弥散 MRI 以及认知测试结果。测量灰质厚度、白质体积和白质弥散张量成像参数,以确定纵向变化。我们通过平均整个白质并使用坑洞分析法来分析扩散张量成像参数。18名血液透析患者参与了纵向分析,15名对照组患者参与了坑洞分析。我们使用美国国立卫生研究院工具箱认知能力测试评估同一时期的认知能力:在血液透析的一年时间里,我们发现整个白质的分数各向异性有所下降(p 讨论):通过采用降噪技术,我们能够检测出血液透析患者弥散张量成像参数的纵向变化。分数各向异性在一年中的下降表明白质健康状况显著下降。然而,我们并未发现分数各向异性的下降与认知能力的下降有关。
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引用次数: 0
Adrenal insufficiency in hemodialysis patients—An under-recognized problem: A case series 血液透析患者肾上腺功能不全--一个认识不足的问题:病例系列。
IF 1.3 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-02-07 DOI: 10.1111/hdi.13131
Krupa Shah, Jeffrey Wong, Kathy Mac, Namson S. Lau, Vincent M. Wong, Angela Makris

Adrenal insufficiency is an uncommon disorder and presents with non-specific symptoms. Identifying adrenal insufficiency in patients with chronic kidney disease requiring dialysis is increasingly difficult as there is a significant overlap of the signs and symptoms of adrenal insufficiency with those seen in chronic kidney failure. We highlight this diagnostic uncertainty in a case series of three patients with chronic kidney disease requiring hemodialysis as renal replacement therapy from a single center identified as hypoadrenal. Steroid replacement improved symptoms and hemodynamic parameters. Increased vigilance for adrenal insufficiency in dialysis patients is necessary. It is likely under recognized in hemodialysis patients given their multi-morbidity.

肾上腺功能不全是一种不常见的疾病,表现为非特异性症状。由于肾上腺功能不全的症状和体征与慢性肾衰竭的症状和体征有很大的重叠,因此在需要透析的慢性肾病患者中识别肾上腺功能不全越来越困难。我们在一个病例系列中强调了这种诊断上的不确定性,该病例系列中的三位慢性肾脏病患者来自一个中心,需要通过血液透析作为肾脏替代疗法,他们被确认为肾上腺功能低下。类固醇替代治疗改善了症状和血液动力学参数。有必要提高对透析患者肾上腺功能不全的警惕。由于血液透析患者多病缠身,他们对肾上腺功能不全的认识可能不足。
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引用次数: 0
We are moving to online only 我们将转为仅在线服务。
IF 1.3 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2024-01-11 DOI: 10.1111/hdi.13129
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引用次数: 0
Effect of conventional hemodialysis on the apixaban plasma concentration 常规血液透析对阿哌沙班血药浓度的影响。
IF 1.3 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2023-11-14 DOI: 10.1111/hdi.13127
Tim Poel, Nikki de Rouw, Nathalie C. V. Péquériaux, Daan van de Kerkhof, Annemieke M.A. Vermeulen Windsant, Rob J. van Marum, Angele P. M. Kerckhoffs

Purpose

Apixaban is a factor Xa inhibitor used in patients undergoing hemodialysis treatment. The objective of this study is to investigate the effect of hemodialysis on apixaban plasma concentrations.

Methods

This observational study is on patients treated with apixaban 2.5 mg twice daily on conventional hemodialysis with standard low-molecular-weight heparin (LMWH) anticoagulation (nadroparin 3800–7600 IU). Plasma blood samples were collected before starting dialysis (t1), 2 h after starting dialysis (t2), and directly after dialysis (t3). Apixaban concentration was measured before and after dialysis. Anti-Xa activity was measured for all three samples.

Results

A significant difference was observed between the apixaban concentration before and after dialysis (mean before dialysis 141.03 ng/mL; mean after dialysis 102.71 ng/mL; p = 0.003). Nonetheless, both apixaban plasma concentrations and anti-Xa levels remained within the reference range. Anti-Xa levels had a strong correlation with the apixaban concentrations (r = 0.935, p = 0.000). Thus, anti-Xa activity might be used as a surrogate for apixaban plasma concentration.

Conclusion

There seems to be no need for dose adjustments of apixaban; co-administration of LMWH next to apixaban might also be unnecessary.

目的:阿哌沙班是一种用于血液透析治疗的Xa因子抑制剂。本研究的目的是探讨血液透析对阿哌沙班血药浓度的影响。方法:本观察性研究采用阿哌沙班2.5 mg,每日2次,常规血液透析患者联合标准低分子肝素(LMWH)抗凝(nadroparin 3800-7600 IU)。开始透析前(t1)、开始透析后2小时(t2)和透析后直接(t3)采集血浆血样。透析前后测定阿哌沙班浓度。测定了三种样品的抗xa活性。结果:透析前后阿哌沙班浓度差异有统计学意义(透析前平均141.03 ng/mL;透析后平均102.71 ng/mL;p = 0.003)。尽管如此,阿哌沙班血浆浓度和抗xa水平仍保持在参考范围内。抗xa水平与阿哌沙班浓度有较强相关性(r = 0.935, p = 0.000)。因此,抗xa活性可作为阿哌沙班血药浓度的替代指标。结论:阿哌沙班似乎无需调整剂量;低分子肝素与阿哌沙班的联合用药也可能是不必要的。
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引用次数: 0
Chronic kidney disease and value-based care: Lessons from innovation, iteration, and ideation in primary care 慢性肾脏疾病和基于价值的护理:初级保健创新、迭代和构思的经验教训。
IF 1.3 4区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2023-11-07 DOI: 10.1111/hdi.13126
Matthew E. Berman, Joshua E. Lowentritt

Value-based primary care has reduced health care costs, improved the quality of rendered care, and enhanced the patient experience. Value-based care emphasizes prevention, outreach, follow-up, patient engagement, and comprehensive, whole-person health. Primary care Accountable Care Organizations have leveraged technology-enabled workflows, practice transformation, and cutting-edge data and analytics to achieve success. These efforts are increasingly aided by predictive modeling used in the context of patient identification and prioritization algorithms. Value-based kidney care programs can glean salient takeaways from successful value-based primary care methods and models. The kidney care community is experiencing unprecedented transformation as novel payer programs and financial models burgeon. The authors contend these efforts can be accelerated by the adoption of techniques honed in value-based primary care. To optimize value-based kidney care, though, nephrology thought leaders must transcend the archetype of value-based primary care. To do so, the nephrology community must: (1) impel behavioral change among fee-for-service adherents; (2) harness emerging policy, guidelines, and quality measures; (3) adopt innovative tools, technologies, and therapies. In aggregating lessons from value-based primary care—and leveraging novel methodologies and approaches—the kidney care community will be better equipped to achieve the quadruple aim for kidney care.

基于价值的初级保健降低了医疗保健成本,提高了提供护理的质量,并增强了患者体验。基于价值观的护理强调预防、外展、随访、患者参与和全面的全人健康。初级保健责任护理组织利用技术支持的工作流程、实践转型以及尖端数据和分析来取得成功。在患者识别和优先级算法的背景下使用的预测建模越来越多地帮助了这些努力。基于价值的肾脏护理项目可以从成功的基于价值的初级护理方法和模式中获得显著的收获。随着新型付款人计划和金融模式的兴起,肾脏护理界正在经历前所未有的变革。作者认为,通过采用在基于价值的初级保健中磨练出来的技术,可以加快这些努力。然而,为了优化基于价值的肾脏护理,肾脏学思想领袖必须超越基于价值的初级保健的原型。要做到这一点,肾病学界必须:(1)推动付费服务追随者的行为改变;(2) 利用新出现的政策、指导方针和质量措施;(3) 采用创新的工具、技术和疗法。通过总结基于价值的初级保健的经验教训,并利用新的方法和方法,肾脏护理界将能够更好地实现肾脏护理的四重目标。
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引用次数: 0
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Hemodialysis International
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