Gynecologic Oncology Reports最新文献_第2页

INDEPSO-ISPSM consensus on peritoneal malignancies – Enhanced recovery after surgery in cytoreductive surgery (CRS) with/without hyperthermic intraperitoneal chemotherapy (HIPEC) INDEPSO-ISPSM关于腹膜恶性肿瘤的共识——细胞减少手术（CRS）伴/不伴腹腔内高温化疗（HIPEC）可增强术后恢复。

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2025-02-01 DOI: 10.1016/j.gore.2024.101662

Geetu Prakash Bhandoria , Arvind Guru , Ajinkya Pawar , Aditi Bhatt , Neha Kumar , Rohit Kumar , Swapnil Patel , Sohan Lal Solanki , Vivek Sukumar , Ashwin K. Rajagopal , S.P. Somashekhar

Background

The role of enhanced recovery after surgery (ERAS) in cytoreductive surgery and/or Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is evolving, with promising results that improve patient outcomes. This consensus exercise was carried out to address and standardize components of the ERAS protocol pertinent to the Indian context.

Method

The modified Delphi method was employed with two rounds of voting. All fifty invited specialists agreed to vote. There were 30 questions addressing the key elements of ERAS protocols. They were broadly distributed across four sections: Prehabilitation, Preoperative, Intraoperative, and Postoperative elements. A consensus was achieved if any one option received > 70 % votes (strong consensus > 90 %). If consensus was not achieved in round 1, the question was moved to round 2.

Results

After rounds I and II, 48/50 (95.8%) of invited panelists voted for the questions. The highest rate of ‘skipped question’ was 6% in both rounds. A consensus was obtained for 28/30 (93.33%) questions, and strong consensus was obtained for 5/30 (16.6%) questions. No consensus was obtained for two questions. Some of the panelists’ recommendations contradicted the standard ERAS guidelines, such as using intraperitoneal drains in all patients and mechanical bowel preparation for left-sided colonic or rectal resections.

Conclusion

Despite some limitations, this consensus exercise represents a significant step toward advancement and pioneering efforts to improve patient outcomes by implementing and standardizing ERAS protocols in CRS and/or HIPEC tailored for India.

背景：增强术后恢复（ERAS）在细胞减少手术和/或腹腔热化疗（HIPEC）中的作用正在发展，有希望的结果可以改善患者的预后。进行这种协商一致的工作是为了处理和标准化与印度情况有关的ERAS议定书的组成部分。方法：采用改进的德尔菲法进行两轮投票。所有受邀的50位专家都同意投票。有30个问题涉及ERAS协议的关键要素。它们广泛分布在四个部分：康复前、术前、术中和术后。如果任何一个选项获得bbb70 %的投票，则达成共识（强共识> 90%）。如果在第1轮未能达成协商一致意见，则将问题移至第2轮。结果：在第一轮和第二轮之后，48/50（95.8%）的受邀小组成员对问题进行了投票。两轮中“跳过问题”的最高比例都是6%。28/30（93.33%）的问题获得一致，5/30（16.6%）的问题获得强烈一致。有两个问题没有取得一致意见。一些专家组成员的建议与标准ERAS指南相矛盾，例如在所有患者中使用腹腔内引流，在左侧结肠或直肠切除术中使用机械肠道准备。结论：尽管存在一些局限性，但通过在印度量身定制的CRS和/或HIPEC中实施和标准化ERAS协议，这一共识活动代表了朝着进步和开创性努力迈出的重要一步。

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引用次数: 0

Views on cervical cancer screening among female caregivers at the Uganda cancer Institute 对乌干达癌症研究所女性护理人员宫颈癌筛查的看法。

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2025-02-01 DOI: 10.1016/j.gore.2024.101654

Martin Origa , Anthony Kayiira , Rahel Ghebre , Lauren Bollinger , Sheila Irene Kisakye , Deanna Teoh

Patients admitted to Uganda Cancer Institute (UCI) have their non-medical needs provided by caregivers called “attendants” who are predominantly female family members. This provides a unique opportunity to provide free screening among attendants during their free time at the hospital. The objective of this qualitative focus group study was to understand knowledge of and facilitators and barriers to cervical cancer screening among attendants at the UCI. The goal is to use these data to inform a future opportunistic intervention. Female attendants 25 years of age or older were included in this focus group study. The focus group discussions explored knowledge of cervical cancer and screening modalities, health information sources, barriers and facilitators for cervical cancer screening, and potential use of mobile phone technology to share cervical cancer screening information among one’s social community. Data were analyzed using an inductive approach and thematic analysis. Results showed moderate understanding of risk factors for cervical cancer, supplemented by misinformation. Knowledge of symptoms of advanced cervical cancer was high. Most participants were aware that cervical cancer screening exists but knew little about screening modalities. Responses were mixed regarding preferred information sources, and included healthcare workers and facilities, radio and family members. Participants were enthusiastic about mobile phone messaging to provide information about screening but emphasized a need to catch their attention and incentivize screening with promise of good such as sugar, demonstrating prioritization of immediate needs over future cancer risk. These results will inform an intervention which aims to connect female caregivers with free screening available at the adjacent cancer prevention clinic.

乌干达癌症研究所收治的病人的非医疗需求由被称为“服务员”的护理人员提供，这些护理人员主要是女性家庭成员。这提供了一个独特的机会，在医院的空闲时间为医护人员提供免费筛查。本定性焦点小组研究的目的是了解UCI服务人员对宫颈癌筛查的知识、促进因素和障碍。目标是利用这些数据为未来的机会干预提供信息。25岁或以上的女性服务员被纳入这项焦点小组研究。焦点小组讨论探讨了子宫颈癌和筛查方式的知识、健康信息来源、子宫颈癌筛查的障碍和促进因素，以及利用移动电话技术在社会群体中分享子宫颈癌筛查信息的可能性。数据分析采用归纳方法和专题分析。结果显示，人们对宫颈癌的危险因素了解适度，但也存在一些错误信息。对晚期子宫颈癌症状的了解程度很高。大多数参与者知道有子宫颈癌筛查，但对筛查方式知之甚少。对于首选的信息来源，反应不一，包括卫生保健工作者和设施、广播电台和家庭成员。参与者热衷于通过手机短信提供有关筛查的信息，但强调有必要引起他们的注意，并以糖等有益的承诺来激励筛查，表明将当前需求置于未来癌症风险之上。这些结果将为一项旨在将女性护理人员与邻近癌症预防诊所提供的免费筛查联系起来的干预措施提供信息。

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引用次数: 0

Provider perspectives on caring for patients with limited English proficiency-a national survey of the Society of Gynecologic Oncology 提供者对英语水平有限的患者护理的观点——妇科肿瘤学会的一项全国调查。

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2025-02-01 DOI: 10.1016/j.gore.2024.101655

S.M. Folsom , A.B. Olawaiye , S.E. Taylor

Background

In diversity, equity and inclusion research, overcoming barriers in language discordant patient care is one of the largest and most challenging gaps. It is well established that patients with limited English proficiency (LEP) have higher rates of misdiagnosis, medical errors, and serious adverse events, and recommended best practices for LEP patient care are often not followed.

Objective

Our team sought to elicit provider perspectives regarding the barriers they face in caring for LEP patients—especially the unique challenges faced when caring for patients with complex and sensitive diagnoses such as gynecologic cancer.

Methods

A national survey was conducted through the Society of Gynecologic Oncology survey database during November and December of 2023. The survey included questions regarding the landscape of LEP patient care in varied geographic settings and practice types. It queried providers regarding available support and resources, as well as tools practitioners would recommend to improve care for LEP patients with gynecologic cancer. The results were assessed using descriptive statistics and Likert Scales and analyzed using t-tests, Fisher’s Exact test, Chi-square analysis and ANOVA.

Results

188 respondents completed the survey. Spanish was the most spoken non-English language in providers’ patient populations; however, 39 different languages were reported as commonly spoken. Providers reported increases in stress and a lack of time in caring for LEP patients. When asked what interventions providers would recommend to improve LEP patient care, providers asked for more in-person interpreters (40%), more written patient instructions in needed languages (32%), and more time (17%).

Conclusions

Understanding barriers to best practices in LEP patient care is vital to planning future interventions. While this survey was limited by the small percentage of respondents, it provides foundational information for future interventions intended to relieve over-burdened practitioners and systems and achieve the ultimate goal of improved outcomes for LEP patients.

背景：在多样性、公平性和包容性研究中，克服语言不和谐患者护理中的障碍是最大和最具挑战性的差距之一。众所周知，英语水平有限（LEP）的患者有更高的误诊率、医疗差错率和严重不良事件发生率，并且推荐的LEP患者护理最佳实践通常不被遵循。目的：我们的团队试图引出提供者关于他们在照顾LEP患者时所面临的障碍的观点，特别是在照顾诊断复杂而敏感的患者（如妇科癌症）时所面临的独特挑战。方法：于2023年11 - 12月通过美国妇科肿瘤学会调查数据库进行全国调查。该调查包括关于不同地理环境和实践类型的LEP患者护理景观的问题。它询问了提供者关于可用的支持和资源，以及从业者会推荐的工具来改善LEP患者妇科癌症的护理。使用描述性统计和李克特量表对结果进行评估，并使用t检验、Fisher精确检验、卡方分析和方差分析进行分析。结果：188名受访者完成了调查。西班牙语是医疗服务提供者患者群体中使用最多的非英语语言；然而，据报道，共有39种不同的语言被广泛使用。提供者报告说，在照顾LEP患者时，压力增加，时间不足。当被问及提供者会推荐哪些干预措施来改善LEP患者护理时，提供者要求更多的现场口译员（40%），更多所需语言的书面患者说明（32%）和更多的时间（17%）。结论：了解LEP患者护理最佳实践的障碍对于规划未来的干预措施至关重要。虽然本次调查受限于受访者比例小，但它为未来的干预措施提供了基础信息，旨在减轻负担过重的从业者和系统，并实现改善LEP患者预后的最终目标。

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引用次数: 0

Hydronephrosis and survival in cervical cancer patients: The role of urinary diversion 宫颈癌患者肾积水与生存：尿改道的作用。

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2025-02-01 DOI: 10.1016/j.gore.2024.101660

María Esther Garza-Montúfar , Gibrán Domingo Carballo-Rosario , Carlos Marcel García-Pérez

Objective

We aimed to assess the impact of urinary diversion on survival in patients with advanced cervical cancer (CC) and hydronephrosis. Additionally, we examined the influence of other patient factors and urinary diversion type on survival.

Methods

A retrospective study analyzed survival in cervical cancer (CC) patients with hydronephrosis treated at two Mexican hospitals from 2011 to 2023. Patient data, including demographics, clinical, and pathological characteristics, were collected. Urinary diversion details and complications were recorded. Survival analysis was performed using Kaplan-Meier method and Cox regression model to identify predictors of survival.

Results

A total of 228 cervical cancer patients presenting with hydronephrosis were analyzed. Median follow-up was 9 months. The majority of patients were in stage IVA (44.3 %), with 66.7 % exhibiting bilateral renal involvement. Urinary diversion was performed in 192 patients (84.2 %). Median overall survival (OS) was 15.5 months. Multivariate analysis identified stage, disease course, oncologic treatment, laterality, performance status, and urinary diversion as independent prognostic factors for survival. In patients undergoing urinary diversion, bilateral renal involvement (HR 2.0) and deteriorated performance status (HR 3.6) were risk factors for mortality. Neither the laterality (unilateral or bilateral) nor the type of diversion significantly affected overall survival.

Conclusions

Survival in CC patients with hydronephrosis is influenced by factors such as: bilateral involvement, performance status, clinical stage, course and treatment of the underlying malignancy and urinary diversion. Urinary diversion improves survival, regardless of the specific diversion type or whether the diversion is unilateral or bilateral.

目的：我们旨在评估尿分流对晚期宫颈癌（CC）合并肾积水患者生存的影响。此外，我们还检查了其他患者因素和尿分流类型对生存的影响。方法：回顾性分析2011年至2023年在墨西哥两家医院治疗的宫颈癌（CC）肾积水患者的生存率。收集患者资料，包括人口统计学、临床和病理特征。记录尿分流细节及并发症。生存分析采用Kaplan-Meier法和Cox回归模型确定生存预测因子。结果：对228例以肾积水为临床表现的宫颈癌患者进行了分析。中位随访为9个月。大多数患者为IVA期（44.3%），其中66.7%表现为双侧肾脏受累。192例（84.2%）患者行尿分流术。中位总生存期（OS）为15.5个月。多变量分析确定分期、病程、肿瘤治疗、侧边性、运动状态和尿分流是影响生存的独立预后因素。在尿改道患者中，双侧肾脏受累（HR 2.0）和运动状态恶化（HR 3.6）是死亡的危险因素。侧边性（单侧或双侧）和转移类型均未显著影响总生存率。结论：CC合并肾积水患者的生存受双侧受累、运动状态、临床分期、病程、潜在恶性肿瘤治疗及尿分流等因素的影响。尿改道提高了生存率，无论具体的改道类型或改道是单侧还是双侧。

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引用次数: 0

Surgical management of endometrial cancer in patient with musculocontractural Ehlers-Danlos Syndrome harboring pathogenic variants in CHST14 (mcEDS-CHST14): A case report 携带 CHST14（mcEDS-CHST14）致病变体的肌肉萎缩性埃勒斯-丹洛斯综合征患者子宫内膜癌的手术治疗：病例报告。

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2025-02-01 DOI: 10.1016/j.gore.2024.101675

Yuta Shioya , Hirofumi Ando , Tsutomu Miyamoto , Koichi Ida , Hisanori Kobara , Tomomi Yamaguchi , Tomoki Kosho , Tanri Shiozawa

Introduction

Musculocontractural Ehlers-Danlos syndrome (mcEDS) is a rare autosomal recessive connective tissue disorder caused by systemic depletion of dermatan sulfate. Symptoms characteristic of mcEDS include multiple contractures, fragile skin with subcutaneous bleeding, and hypermobile joints, which suggest difficulty in perioperative management. However, safe surgical techniques and perioperative management of this disorder remain unknown because of its rarity. We report a patient with mcEDS who developed endometrial cancer and underwent surgery, with emphasis on perioperative management.

Case report

A female patient, who had been genetically diagnosed with mcEDS-CHST14 at the age of 25, presented with symptoms characteristic of mcEDS, including: congenital contractures of fingers and clubfeet, recurrent joint dislocation, progressive foot and spinal deformities, and large subcutaneous hematomas. At age 33, she had been diagnosed with atypical endometrial hyperplasia, and scheduled to undergo total abdominal hysterectomy. To address the risk of massive hemorrhage during the surgery due to mcEDS-related tissue fragility, plasma-derived factor VIII concentrate was prophylactically administered before surgery. During the surgery, neither fragility, hyperextensibility, nor hemorrhagic tendency of the uterus or adnexa observed was observed. The surgery was uneventful, with blood loss of 180 mL and operative time of 2 h and 54 min. However, on the sixth postoperative day, a 2.5-cm dissection was noted at the site of skin incision. Subcutaneous fluid accumulation developed under the skin incision and it persisted for 1.5 months. The postoperative pathological diagnosis was endometrioid carcinoma grade 1, stage IA.

Conclusion

The present case suggested that the prophylactic use of factor VIII was effective for the prevention of hemorrhage during surgery. However, delayed wound healing of the skin and subcutaneous tissues was considered a subject for future improvement.

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引用次数: 0

Recurrence and survival in high-intermediate risk endometrial cancers with isolated tumor cell lymph node metastasis

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2025-02-01 DOI: 10.1016/j.gore.2025.101684

Ahmad Awada, Fernando O. Recio, Theresa M. Kuhn, Sarfraz Ahmad, Jianbin Zhu, Nathalie D. McKenzie, James E. Kendrick, Robert W. Holloway

Objective

To compare clinical outcomes of patients with early-stage, high-intermediate risk (HIR) endometrial cancer (EC) and isolated tumor cells (ITC) lymph node metastases treated with chemotherapy/radiotherapy (CRT) vs. external beam radiotherapy (EBRT)/vaginal brachytherapy (VBT).

Methods

We retrospectively identified all patients with early-stage HIR endometrioid EC and ITC treated with CRT or EBRT from our institutional database (January-2015 to December-2023). All patients underwent sentinel lymph node (SLN) assessments per NCCN guidelines. Progression-free survival (PFS) and cancer specific survival (CSS) were analyzed using Kaplan-Meier method. We utilized a GOG-99 scoring system in the HIR-ITC cohort to assess risk factors for recurrence.

Results

48 patients were identified, 32(67 %) treated with CRT, 15(31 %) with EBRT and 1(2 %) with VBT alone. Median follow-up was 63.2 and 28 months in CRT vs EBRT/VBT, respectively (p = 0.001). In CRT cohort, 4(12.5 %) recurred; two patients with isolated lung metastasis were salvaged and two with multiple sites of metastasis died with disease. No patient in EBRT/VBT cohort (n = 16) recurred. Estimated PFS were 84.4 % and 100 % for CRT and EBRT/VBT, respectively (p = 0.392), and CSS were 93.7 % vs. 100 %, respectively (p = 0.457). Using HIR scoring per GOG-99, 21(66 %) patients in CRT cohort had three or more HIR risk factors and 4(19 %) recurred despite adjuvant therapy.

Conclusion

In this retrospective study, there was no significant difference in survival for patients with HIR endometrial cancer and ITC SLNs treated with either EBRT/VBT or CRT. Patients with three or more HIR risk factors remain at risk for recurrence despite CRT. Further prospective studies should assess recurrence risk factors in HIR EC with ITC, likely incorporating standard histopathology and molecular profiles to tailor adjuvant CRT.

目的比较化疗/放疗（CRT）与体外射束放疗（EBRT）/阴道近距离放疗（VBT）治疗早期高危（HIR）子宫内膜癌（EC）和孤立肿瘤细胞（ITC）淋巴结转移患者的临床疗效。方法我们从本机构的数据库中回顾性地识别了所有接受CRT或EBRT治疗的早期HIR子宫内膜癌和ITC患者（2015年1月至2023年12月）。根据 NCCN 指南，所有患者均接受了前哨淋巴结 (SLN) 评估。无进展生存期（PFS）和癌症特异性生存期（CSS）采用 Kaplan-Meier 法进行分析。我们在 HIR-ITC 队列中使用了 GOG-99 评分系统来评估复发的风险因素。结果 48 例患者中，32 例（67%）接受了 CRT 治疗，15 例（31%）接受了 EBRT 治疗，1 例（2%）仅接受了 VBT 治疗。CRT与EBRT/VBT的中位随访时间分别为63.2个月和28个月（P = 0.001）。在 CRT 组别中，4 例（12.5%）患者复发；2 例肺部孤立转移的患者获救，2 例多处转移的患者因病死亡。EBRT/VBT队列（n=16）中没有患者复发。CRT 和 EBRT/VBT 的估计 PFS 分别为 84.4% 和 100%（p = 0.392），CSS 分别为 93.7% 和 100%（p = 0.457）。结论在这项回顾性研究中，接受 EBRT/VBT 或 CRT 治疗的 HIR 子宫内膜癌和 ITC SLN 患者的生存率没有显著差异。有三个或三个以上 HIR 危险因素的患者尽管接受了 CRT 治疗，但仍有复发风险。进一步的前瞻性研究应评估伴有ITC的HIR EC的复发风险因素，可能会结合标准组织病理学和分子图谱来定制辅助CRT。

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引用次数: 0

Pulsed electric field (PEF) treatment of refractory vulvar melanoma concurrently treated with immune checkpoint blockade demonstrating an abscopal response: A case report 脉冲电场（PEF）治疗难治性外阴黑色素瘤同时治疗免疫检查点阻断显示出体外反应：一个病例报告。

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2025-02-01 DOI: 10.1016/j.gore.2024.101671

Daniel B. Knight , Hannah Hillard , Chauncy Handran , Patrick Kuhlman

引用次数: 0

Attitudes, beliefs and preferences surrounding home-based exercise programs in endometrial cancer patients receiving treatment 接受治疗的子宫内膜癌患者对家庭运动项目的态度、信念和偏好。

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2025-02-01 DOI: 10.1016/j.gore.2024.101659

Jessica Gorzelitz , Morolake Adeagbo , Simon Dungan-Seaver , Emily K. Hill , Amanika Kumar , Michael J. Goodheart , Susan Lutgendorf

Background

Despite recommendations, exercise participation among endometrial cancer survivors remains low. Previous interventions focused on weight loss or in-person programs with limited reach. Regular exercise, regardless of weight change, reduces mortality risk and improves functionality. Home-based programs could address participation barriers. We conducted a qualitative study with inactive survivors to identify key factors for future home-based exercise programs.

Methods

Semi-structured interviews were conducted with ten on-treatment endometrial cancer survivors who reported low physical activity levels. Interviews, conducted via Zoom or telephone, were recorded with consent. Transcripts were coded using MAXQDA to identify attitudes, knowledge, barriers, interests, and preferences regarding home-based exercise programs.

Results

The interviews yielded four major themes, the first being the understanding survivors have of what exercise is and the perceived benefits of exercise. Second, participants were acutely aware of the barriers to exercise which included: health issues, treatment-related concerns, access to resources, limited strength, lack of support, and past negative experiences. The third theme focused on motivational factors to exercise including guidance, support systems, access to resources including technology, and a desire to be healthy as motivators towards changing exercise behaviors. Finally, participants expressed interest in exercise that incorporated fun with low impact and accessibility. Interestingly, all the participants preferred home-based exercise programs. The role of the provider/oncologist was often identified as central to the discussion or suggestion of exercise in our sample.

Conclusions

Understanding patient needs and preferences is crucial for creating accessible and sustainable exercise programs for endometrial cancer survivors. Our study guides the development of future home-based exercise programs for this population.

背景：尽管建议，子宫内膜癌幸存者的运动参与仍然很低。以前的干预措施侧重于减肥或覆盖面有限的面对面项目。无论体重变化如何，定期锻炼都能降低死亡风险，改善身体机能。以家庭为基础的项目可以解决参与障碍。我们对不运动的幸存者进行了定性研究，以确定未来家庭锻炼计划的关键因素。方法：对10名正在接受治疗的子宫内膜癌幸存者进行半结构化访谈。通过Zoom或电话进行的采访都是在征得同意的情况下进行的。使用MAXQDA对成绩单进行编码，以确定对家庭锻炼计划的态度、知识、障碍、兴趣和偏好。结果：访谈产生了四个主要主题，第一个是幸存者对运动是什么以及运动的好处的理解。其次，参与者敏锐地意识到运动的障碍包括：健康问题、与治疗有关的问题、资源获取、力量有限、缺乏支持和过去的负面经历。第三个主题关注运动的激励因素，包括指导、支持系统、获得包括技术在内的资源以及对健康的渴望，这些都是改变运动行为的激励因素。最后，参与者表达了对结合低影响和可及性的乐趣的锻炼的兴趣。有趣的是，所有的参与者都更喜欢在家锻炼。在我们的样本中，提供者/肿瘤学家的角色通常被认为是讨论或建议锻炼的核心。结论：了解患者的需求和偏好对于为子宫内膜癌幸存者创建可获得和可持续的锻炼计划至关重要。我们的研究指导了未来针对这一人群的家庭锻炼计划的发展。

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引用次数: 0

Endometrioid adenocarcinoma of the colon arising from rare malignant transformation of extra-gonadal endometrioma 结肠子宫内膜样腺癌是由性腺外子宫内膜瘤的罕见恶性转化引起的。

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2025-02-01 DOI: 10.1016/j.gore.2024.101664

Anne Stoklosa , Youngeun Armbuster , Lila Marshall , Jamie L McDowell , Naixin Zhang , Ashlee Smith , Cynthia Angel , Aaron Varghese , Wei Huang , Richard Moore

Background

Endometriosis is a common condition with a rare malignant potential. We report a case of a patient with a colon mass who underwent surgery for malignant endometriosis associated cancer.

Case: A 70-year-old woman with a pelvic mass who was lost to follow-up for 6 years represented with an enlarging pelvic mass involving the sigmoid colon. The patient underwent colonoscopy which revealed atypical endometrial-type glandular proliferation. She then underwent exploratory laparotomy with total abdominal hysterectomy, bilateral salpingo-oophorectomy, rectosigmoid resection, and creation of end colostomy. Final pathology revealed endometrioid adenocarcinoma arising from colon serosal endometriosis. Observation or systemic chemotherapy were considered, and patient opted for observation.

Conclusion

We report a case of malignant intestinal endometriosis. There is limited evidence to support a standardized approach to treatment due to the rare nature of this disease; the patient opted for observation. By understanding the presentation, diagnostic workup, and outcomes of each patient with malignant endometriosis, future research can be guided to ultimately improve patient outcomes.

背景：子宫内膜异位症是一种常见的疾病，具有罕见的恶性潜能。我们报告一例患者结肠肿块谁接受手术恶性子宫内膜异位症相关的癌症。病例：一名70岁女性骨盆肿块，随访6年未见，骨盆肿块扩大，累及乙状结肠。患者行结肠镜检查，发现非典型子宫内膜型腺体增生。随后，她接受了剖腹探查术、全腹子宫切除术、双侧输卵管-卵巢切除术、直肠乙状结肠切除术和末端结肠造口术。最终病理显示为结肠浆膜子宫内膜异位症引起的子宫内膜样腺癌。考虑观察或全身化疗，患者选择观察。结论：我们报告一例恶性肠道子宫内膜异位症。由于这种疾病的罕见性，支持标准化治疗方法的证据有限；病人选择观察。通过了解每个恶性子宫内膜异位症患者的表现、诊断检查和结果，可以指导未来的研究，最终改善患者的预后。

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引用次数: 0

Neovaginal squamous cell carcinoma in a transgender woman: Case report, treatment insights, and literature review

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2025-02-01 DOI: 10.1016/j.gore.2025.101686

Manengue Arsene , Nantier Émilie Marie-Christine , Pelland Marie-Ève , Beauchemin Marie-Claude , Bourque Jean-Marc

引用次数: 0