Gynecologic Oncology Reports最新文献

英文中文

Improving clinical trial enrollment in minority racial and ethnic patients with gynecologic malignancy 提高少数种族和族裔妇科恶性肿瘤患者的临床试验注册率

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2024-08-31 DOI: 10.1016/j.gore.2024.101495

Olivia D. Lara , Kathryn Allen , Amin Yakubov , Bhavana Pothuri

Purpose

Racial and ethnic minorities remain underrepresented in clinical trials . Underrepresentation of racial groups leads to the selection of therapeutic interventions that may not be representative of the population expected to use the medicine. This study evaluates the effectiveness of a set of implementation strategies to increase underrepresented patients in gynecologic cancer clinical trials.

Methods

An interrupted time series analysis evaluating implementation strategies (pre-screening and fast-track referral) was conducted from January 2021 to May 2022. Descriptive analysis of gynecologic oncology patient screening and accrual was compared before and after intervention implementation.

Results

During the study period (pre- and post-intervention), 26 patients were screened, and 9 patients enrolled in therapeutic gynecologic cancer clinical trials. Prior to the intervention, 7 patients were screened and 2 patients enrolled onto a clinical trial. Following the intervention, 19 patients were screened and 7 patients enrolled in a cancer clinical trial. Black patients comprised 13 of 19 (68.4%) of patients post-intervention compared to 1 of 7 (14.3 %) of patients screened pre-intervention (p < 0.05). All 7 patients enrolled post intervention were racial and ethnic minorities (non-Hispanic Black [4 of 7] and Hispanic White [3 of 7]) compared to no minority patients enrolled pre-intervention (p < 0.05). Screening increased 2.5-fold for all patients, and 5- fold for minority patients. Clinical trial enrollment increased 3.5-fold following intervention.

Conclusions

A combination of pre-screening and fast-track referral intervention in a racial and ethnically diverse urban academic hospital was associated with a significant increase in minority screening and enrollment. Structured strategies to overcome barriers to underrepresented racial and ethnic patient accrual in academic hospitals are urgently warranted.

目的少数种族和少数民族在临床试验中的代表性仍然不足。种族群体代表性不足导致选择的治疗干预措施可能无法代表预期用药人群。本研究评估了一套实施策略的有效性，以增加妇科癌症临床试验中代表性不足的患者。方法从 2021 年 1 月到 2022 年 5 月，对实施策略（预筛查和快速转诊）进行了间断时间序列分析评估。结果在研究期间（干预前和干预后），26 名患者接受了筛查，9 名患者参加了治疗性妇科癌症临床试验。干预前，7 名患者接受了筛查，2 名患者参加了临床试验。干预后，19 名患者接受了筛查，7 名患者参加了癌症临床试验。干预后，19 名患者中有 13 名（68.4%）是黑人，而干预前，7 名患者中有 1 名（14.3%）是黑人（p < 0.05）。干预后登记的 7 名患者均为少数种族和族裔（非西班牙裔黑人 [7 人中的 4 人] 和西班牙裔白人 [7 人中的 3 人]），而干预前没有登记少数种族患者（p < 0.05）。所有患者的筛查率提高了 2.5 倍，少数民族患者的筛查率提高了 5 倍。结论在一家种族和民族多元化的城市学术医院中，结合预筛查和快速转诊干预措施可显著提高少数民族筛查率和入院率。迫切需要采取结构化策略来克服学术医院中少数种族和民族患者入组的障碍。

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引用次数: 0

Case Series: Rare cystic variant of adenomatoid tumor of the uterus 病例系列：子宫腺瘤样肿瘤的罕见囊性变体

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2024-08-28 DOI: 10.1016/j.gore.2024.101493

Prasanna D Tati , Muhammad Omar Afridi , Angelica Patel , Monika Mansmann , Victoria Petty , Joyce Varughese

引用次数: 0

Ureteral stenting in patients with locally advanced cervical cancer: Predictors of low success rate 局部晚期宫颈癌患者的输尿管支架植入术：低成功率的预测因素

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2024-08-28 DOI: 10.1016/j.gore.2024.101491

Kaleab Habtemichael Gebreselassie , Tadele Aweke Adamu , Andualem Deneke Beyene

Objective

Cervical cancer is the leading gynecologic malignancy in Ethiopia. The diagnosis is often delayed and many patients present with locally advanced disease. Involvement of the ureters with or without the development of hydroureteronephrosis is a common finding. Ureteral stent placement is a modality utilized to relieve an established obstruction (therapeutic) or to prevent its early occurrence (prophylactic). However, the procedure may not be successful in all patients. The objective of this study is to assess the factors associated with low success rate of ureteral stenting in these patients with locally advanced disease.

Methods

This is a hospital based cross-sectional study of patients diagnosed with locally advanced cervical cancer for whom a retrograde ureteral stent placement is attempted from January 2019 to March 2020. Data of 175 patients were retrieved by a retrospective chart review and analyzed for factors associated with low procedural success.

Results

Socio-demographic data were similar between patients regardless of procedural success. The overall success rate of stenting was 54.2 %. In the prophylactic group (with no hydronephrosis and normal creatinine) success rate was 94 % and in the therapeutic group 42.6 %. Logistic regression analysis showed that bilateral hydronephrosis and increased serum creatinine were indicators of significant ureteral obstruction and were predictors of stent placement failure.

Conclusion

Increased serum creatinine and presence of hydronephrosis are risk factors for failed ureteral stenting. For these patients, other options of urinary diversion such as percutaneous nephrostomy should be considered from the outset.

目的宫颈癌是埃塞俄比亚最主要的妇科恶性肿瘤。宫颈癌的诊断常常被延误，许多患者都是局部晚期。输尿管受累并伴有或不伴有输尿管肾积水是一种常见病。输尿管支架置入术可用于缓解已形成的梗阻（治疗性）或预防早期梗阻的发生（预防性）。然而，并非所有患者都能成功实施该手术。本研究旨在评估这些局部晚期患者输尿管支架置入术成功率低的相关因素。方法这是一项基于医院的横断面研究，研究对象是2019年1月至2020年3月期间被诊断为局部晚期宫颈癌并尝试逆行性输尿管支架置入术的患者。通过回顾性病历检索了175名患者的数据，并分析了与手术成功率低相关的因素。结果无论手术成功与否，患者的社会人口学数据相似。支架植入术的总体成功率为 54.2%。预防组（无肾积水且肌酐正常）的成功率为 94%，治疗组为 42.6%。Logistic 回归分析表明，双侧肾积水和血清肌酐升高是输尿管严重梗阻的指标，也是支架置入失败的预测因素。对于这些患者，从一开始就应考虑其他尿路改道方案，如经皮肾造瘘术。

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引用次数: 0

Recurrent high grade serous endometrial cancer with brain metastases: Immunotherapy confers improved quality of life and survival 复发性高级别浆液性子宫内膜癌伴脑转移：免疫疗法可提高生活质量和生存率

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2024-08-28 DOI: 10.1016/j.gore.2024.101494

Kierany B. Shelvin , Jill Vincent , Shawna Morron , Michael Morin , Aaron Mammoser , Navya Nair

引用次数: 0

Management of high-grade ovarian adenocarcinoma in an intraperitoneal pelvic renal transplant recipient 腹腔内盆腔肾移植受者高级别卵巢腺癌的处理方法

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2024-08-22 DOI: 10.1016/j.gore.2024.101489

Esra Demirel , Seth Cohen , Ronald D. Ennis , Farr R. Nezhat

Background

Number of organ transplant recipients continues to rise worldwide with increasing accessibility and growing advancements in transplant medicine. Transplant patients have at least a two-to-four fold higher risk of developing cancer compared to the general population. As the prevalence of transplant patients increases, a growing number of these patients are expected to present with concurrent conditions such as cancer, requiring more complex and interdisciplinary care.

Case

A 44-year-old patient with an intraperitoneal pelvic renal transplant, found to have high-grade ovarian adenocarcinoma most likely arising from endometriosis, successfully underwent surgical staging, adjuvant chemotherapy, and subsequent pelvic radiation for recurrence. Her kidney function and graft viability were preserved throughout her treatment with careful monitoring.

Conclusion

Management of reproductive tract cancers in kidney transplant recipients is complex. Current practices largely rely on evidence from observational studies and case reports for these cancers and more research is needed in this area.

背景随着器官移植的普及和移植医学的不断发展，全球器官移植受者的数量持续上升。与普通人群相比，器官移植患者罹患癌症的风险至少高出两到四倍。病例一名 44 岁的患者接受了腹腔内肾盂移植手术，被发现患有很可能由子宫内膜异位症引发的高级别卵巢腺癌，她成功接受了手术分期、辅助化疗和随后的盆腔放疗以防复发。在整个治疗过程中，她的肾功能和移植物存活能力都得到了很好的保护。肾移植受者生殖道癌症的治疗非常复杂，目前的治疗方法主要依赖于观察性研究和病例报告中的证据，在这一领域还需要更多的研究。

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引用次数: 0

Near fatal case of mirvetuximab soravtansine-gynx induced interstitial lung disease and a review of the primary literature 米尔韦曲单抗-索拉坦星-gynx诱发间质性肺病的近乎致命病例及主要文献综述

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2024-08-22 DOI: 10.1016/j.gore.2024.101486

Joshua Clark , Andrew Blake , Scott Vasher , Richard C. Boucher , Alexis R. Jones , Hee Jae Choi , Benjamin B. Albright

引用次数: 0

Time series and risk factors associated with mortality in women with cervical cancer from 2000 to 2021 2000 年至 2021 年与宫颈癌妇女死亡率相关的时间序列和风险因素

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2024-08-22 DOI: 10.1016/j.gore.2024.101490

Talita de Oliveira Lima, José Erialdo da Silva Junior, Giulianna Aparecida Vieira Barreto, Max Wellington Sátiro Justino, Maria Lia Coutinho Carvalho, Marcelo Gurgel Carlos da Silva, Daniele Alves Ferreira, Lúcio Flávio Gonzaga Silva, Paulo Goberlânio de Barros Silva

Introduction

Cervical cancer is a significant public health problem worldwide. The development of cervical neoplasms is associated with persistent infection by oncogenic subtypes of the HPV virus, which are responsible for around 70% of cervical cancers.A study carried out in Brazil between 2002 and 2021 recorded 133,429 deaths from cervical cancer..

Methodology

An observational, retrospective, cross-sectional, quantitative study was carried out using data collected by the Cancer Registry Service of the Haroldo Juaçaba Hospital/Ceará Cancer Institute (HHJ/ICC) over 22 years.

Results

The sample consisted of 9096 women. The mean age was 51.4 ± 15.5, ranging from 15 to 100, with a median age of 60 years. Median overall survival was 59.77. The most frequent histological type was squamous cell carcinoma, with 8023 (88.2 %) cases. Around 25 % of patients (n = 2270) entered the service with stage 4A. The most common treatment was radiotherapy combined with chemotherapy (n = 3270, 35.9 %), followed by surgical removal (n = 1909, 21.0 %).In multivariate analysis, age (p = 0.019), race (p = 0.016), low level of education (p < 0.001), tumor location, staging (p < 0.001), and treatment (p = 0.011) were risk factors independently associated with a higher chance of death in the sample studied.

Conclusion

The sociodemographic characteristics of mortality from cervical cancer in patients followed up at the Haroldo Juaçaba Hospital (HHJ/ICC) highlight the higher frequency of deaths in women aged over 60, indigenous and black, with low levels of education, as well as clinical variables related to tumor location, staging and type of treatment.

导言：宫颈癌是全球范围内的一个重大公共卫生问题。宫颈肿瘤的发生与人类乳头状瘤病毒致癌亚型的持续感染有关，约 70% 的宫颈癌是由人类乳头状瘤病毒引起的。该研究利用 Haroldo Juaçaba 医院/卡拉癌症研究所（HHJ/ICC）癌症登记处 22 年来所收集的数据，开展了一项观察性、回顾性、横断面定量研究。平均年龄为 51.4 ± 15.5 岁，从 15 岁到 100 岁不等，中位年龄为 60 岁。总生存期中位数为 59.77。最常见的组织学类型是鳞状细胞癌，共有 8023 例（88.2%）。约25%的患者（2270人）在接受治疗时已处于4A期。在多变量分析中，年龄（p = 0.019）、种族（p = 0.016）、教育程度低（p <0.001）、肿瘤位置、分期（p <0.001）和治疗（p = 0.011）是与研究样本中较高死亡几率独立相关的风险因素。结论在哈罗尔多-华萨巴医院（HHJ/ICC）接受随访的宫颈癌患者的社会人口学死亡特征显示，60 岁以上、土著、黑人、受教育程度低的女性死亡频率较高，与肿瘤位置、分期和治疗类型相关的临床变量也较高。

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引用次数: 0

Endometrial cancer of both uterine horns in a premenopausal patient with uterine didelphys: Surgical approach and considerations for adjuvant treatment 一名绝经前子宫畸形患者的双子宫角子宫内膜癌：手术方法和辅助治疗的考虑因素

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2024-08-22 DOI: 10.1016/j.gore.2024.101492

Meyha Swaroop , Anna Nevels , Meg Hubregsen , Janelle P. Darby

引用次数: 0

Pseudomyxoma peritonei arising from mature ovarian teratoma, a rare entity: Report of six cases and review of current literature 成熟卵巢畸胎瘤引发的假性腹膜肌瘤，一种罕见病例：六例病例报告及最新文献综述

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2024-08-18 DOI: 10.1016/j.gore.2024.101488

Minah Ha , Amy Jamieson , Justine Pickett , Justin M. McGinnis , Tom De Greve

Background

Pseudomyxoma peritonei (PMP) is a clinical syndrome characterised by intraperitoneal accumulation of mucus due to mucinous neoplasia. It is a rare condition affecting 1–2 per million individuals per year. The majority of PMP arises from a ruptured mucinous appendiceal tumour, with infrequent occurrences from other primary gastrointestinal tumours and mucinous ovarian tumours. PMP arising from a mature ovarian teratoma is a rare entity, with limited case reports in the literature. Given the infrequent and sporadic occurrences of these tumours, little is known about the tumour behaviour and prognosis.

Case series and literature review

Herein, we report six cases of PMP arising from a mature ovarian teratoma who were treated with primary cytoreductive surgery (CRS), with one case of recurrence. Literature review identified 21 cases from 12 manuscripts. Nineteen patients were treated with CRS alone, with two patients receiving adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC). Follow up data were variably reported, with no recurrence in 20 patients during their follow up of 5–54 months. One patient reported to have died of disease at 49 months.

Conclusion

Despite the lack of high-quality evidence and limitations of small case series, our review indicates that close surveillance after CRS could be considered as the preferred treatment over more morbid CRS and HIPEC, with HIPEC reserved for patients who recur or progress after CRS.

背景腹膜假性粘液瘤（PMP）是一种临床综合征，其特征是粘液瘤导致的腹腔内粘液积聚。这是一种罕见的疾病，每年每百万人中有 1-2 人患病。大多数 PMP 由阑尾粘液性肿瘤破裂引起，其他原发性胃肠道肿瘤和卵巢粘液性肿瘤引起的 PMP 并不多见。由成熟卵巢畸胎瘤引起的 PMP 比较罕见，文献中的病例报告也很有限。病例系列和文献综述在此，我们报告了六例成熟卵巢畸胎瘤引起的 PMP 病例，这些病例均接受了初级细胞减灭术（CRS）治疗，其中一例复发。文献综述发现了 12 篇手稿中的 21 个病例。19例患者仅接受了CRS治疗，2例患者接受了辅助性腹腔内热化疗（HIPEC）。随访数据的报告各不相同，有20名患者在5-54个月的随访期间没有复发。结论尽管缺乏高质量的证据和小型病例系列的局限性，但我们的综述表明，CRS 后的严密监测可被视为优于发病率较高的 CRS 和 HIPEC 的首选治疗方法，HIPEC 仅用于 CRS 后复发或进展的患者。

{"title":"Pseudomyxoma peritonei arising from mature ovarian teratoma, a rare entity: Report of six cases and review of current literature","authors":"Minah Ha , Amy Jamieson , Justine Pickett , Justin M. McGinnis , Tom De Greve","doi":"10.1016/j.gore.2024.101488","DOIUrl":"10.1016/j.gore.2024.101488","url":null,"abstract":"<div><h3>Background</h3><p>Pseudomyxoma peritonei (PMP) is a clinical syndrome characterised by intraperitoneal accumulation of mucus due to mucinous neoplasia. It is a rare condition affecting 1–2 per million individuals per year. The majority of PMP arises from a ruptured mucinous appendiceal tumour, with infrequent occurrences from other primary gastrointestinal tumours and mucinous ovarian tumours. PMP arising from a mature ovarian teratoma is a rare entity, with limited case reports in the literature. Given the infrequent and sporadic occurrences of these tumours, little is known about the tumour behaviour and prognosis.</p></div><div><h3>Case series and literature review</h3><p>Herein, we report six cases of PMP arising from a mature ovarian teratoma who were treated with primary cytoreductive surgery (CRS), with one case of recurrence. Literature review identified 21 cases from 12 manuscripts. Nineteen patients were treated with CRS alone, with two patients receiving adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC). Follow up data were variably reported, with no recurrence in 20 patients during their follow up of 5–54 months. One patient reported to have died of disease at 49 months.</p></div><div><h3>Conclusion</h3><p>Despite the lack of high-quality evidence and limitations of small case series, our review indicates that close surveillance after CRS could be considered as the preferred treatment over more morbid CRS and HIPEC, with HIPEC reserved for patients who recur or progress after CRS.</p></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S235257892400167X/pdfft?md5=4464113ec05d4dd1440c5d226da0e7d1&pid=1-s2.0-S235257892400167X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports

Pub Date : 2024-08-15 DOI: 10.1016/j.gore.2024.101481

Sattyajit Datta , Syed Baqui Billah , Anik Halder , Tarequr Rahman

Introduction

Cervical cancer is an important public health issue in Bangladesh. Despite government efforts, the awareness and healthcare utilization in rural areas are inadequate.

Methodology

This cross-sectional study was conducted in six districts of Barishal division over 997 respondents aged 15–64 years. The demographic variables, accessibility to healthcare, vaccination status, awareness of HPV causing cervical cancer, and knowledge of the HPV vaccine were recorded through a structured questionnaire. T-test for univariate and chi-square test for bi-variate analysis were used. Logistic regression was used to determine factors associated with awareness.

Results

Most of the participants were SSC passed (45.3%), unemployed (54.4%), and married (74.4%). While 83.5% were aware of cervical cancer, only 3.3% knew about HPV’s role. The majority (96.2%) had never been tested for HPV, albeit 79.5% knew about the vaccine, and only 2.45% were vaccinated. Knowledge levels were low, with only 1.4% demonstrating sound knowledge, mostly associating with higher income, residing closer to healthcare facilities, and being married. Bhola district participants had highest level of awareness, and the lowest was in Pirojpur. Education level was positively correlated with knowledge, with graduates being most aware. Logistic regression showed education, marital status, willingness to vaccinate daughters, and district were significantly related with better awareness, while income, distance, and age did not.

Conclusion

Mass education and awareness campaigns may improve the awareness level in rural community.

导言宫颈癌是孟加拉国的一个重要公共卫生问题。尽管政府做出了努力，但农村地区对宫颈癌的认识和医疗保健利用率仍然不足。通过结构化问卷记录了人口统计学变量、医疗保健可及性、疫苗接种情况、对 HPV 导致宫颈癌的认识以及对 HPV 疫苗的了解。单变量分析采用 T 检验，双变量分析采用卡方检验。结果大多数参与者通过了 SSC 考试（45.3%），失业（54.4%），已婚（74.4%）。83.5%的人知道宫颈癌，但只有 3.3%的人知道 HPV 的作用。大多数人（96.2%）从未接受过人乳头瘤病毒检测，尽管有 79.5%的人知道疫苗，但只有 2.45%的人接种过疫苗。知识水平较低，只有 1.4% 的人表现出良好的知识水平，这主要与收入较高、居住地离医疗机构较近以及已婚有关。博拉区参与者的认知水平最高，皮罗杰布尔区最低。教育水平与知识水平呈正相关，毕业生的知识水平最高。逻辑回归结果显示，教育程度、婚姻状况、为女儿接种疫苗的意愿和地区与更好的认知度有显著关系，而收入、距离和年龄则没有关系。

{"title":"Factors related to cervical cancer and human papilloma virus awareness among rural women of southern Bangladesh: A cross-sectional study","authors":"Sattyajit Datta , Syed Baqui Billah , Anik Halder , Tarequr Rahman","doi":"10.1016/j.gore.2024.101481","DOIUrl":"10.1016/j.gore.2024.101481","url":null,"abstract":"<div><h3>Introduction</h3><p>Cervical cancer is an important public health issue in Bangladesh. Despite government efforts, the awareness and healthcare utilization in rural areas are inadequate.</p></div><div><h3>Methodology</h3><p>This cross-sectional study was conducted in six districts of Barishal division over 997 respondents aged 15–64 years. The demographic variables, accessibility to healthcare, vaccination status, awareness of HPV causing cervical cancer, and knowledge of the HPV vaccine were recorded through a structured questionnaire. T-test for univariate and chi-square test for bi-variate analysis were used. Logistic regression was used to determine factors associated with awareness.</p></div><div><h3>Results</h3><p>Most of the participants were SSC passed (45.3%), unemployed (54.4%), and married (74.4%). While 83.5% were aware of cervical cancer, only 3.3% knew about HPV’s role. The majority (96.2%) had never been tested for HPV, albeit 79.5% knew about the vaccine, and only 2.45% were vaccinated. Knowledge levels were low, with only 1.4% demonstrating sound knowledge, mostly associating with higher income, residing closer to healthcare facilities, and being married. Bhola district participants had highest level of awareness, and the lowest was in Pirojpur. Education level was positively correlated with knowledge, with graduates being most aware. Logistic regression showed education, marital status, willingness to vaccinate daughters, and district were significantly related with better awareness, while income, distance, and age did not.</p></div><div><h3>Conclusion</h3><p>Mass education and awareness campaigns may improve the awareness level in rural community.</p></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352578924001607/pdfft?md5=2b3ec36872e055f6923b591a8e58f141&pid=1-s2.0-S2352578924001607-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141998154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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