Michael E Wechsler, Jared Silver, Gerhard Wolff, Robert G Price, Rejina Verghis, Peter F Weller, Peter A Merkel, Paneez Khoury
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, relapsing, inflammatory disease. Management of EGPA predominantly relies on oral corticosteroids (OCS), which are associated with many adverse effects. The Phase III MIRRA trial demonstrated efficacy and safety of mepolizumab, anti-interleukin-5 biologic, for EGPA. This open-label extension (OLE) of MIRRA assessed long-term safety and OCS-sparing effects of mepolizumab.
{"title":"Long-Term Safety and Efficacy of Mepolizumab in Eosinophilic Granulomatosis With Polyangiitis","authors":"Michael E Wechsler, Jared Silver, Gerhard Wolff, Robert G Price, Rejina Verghis, Peter F Weller, Peter A Merkel, Paneez Khoury","doi":"10.1002/art.43146","DOIUrl":"https://doi.org/10.1002/art.43146","url":null,"abstract":"Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, relapsing, inflammatory disease. Management of EGPA predominantly relies on oral corticosteroids (OCS), which are associated with many adverse effects. The Phase III MIRRA trial demonstrated efficacy and safety of mepolizumab, anti-interleukin-5 biologic, for EGPA. This open-label extension (OLE) of MIRRA assessed long-term safety and OCS-sparing effects of mepolizumab.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"1 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Alehashemi, Bjoern Buehring, Adriana A de Jesus, Sachin Gaurav, Andre Rastegar, Alexi Baumgardner, Kip Friend, Oluwatobi T. Arisa, William D. Figg, Danielle Fink, Douglas B. Kuhns, Ben Colton, Cody J Peer, Raphaela Goldbach-Mansky
To report the efficacy and safety of interferon-β (IFNβ) neutralizing monoclonal antibody (dazukibart), followed by treatment with anti-IFNAR1 antibody (anifrolumab), in a patient with STING-associated vasculopathy with onset in infancy (SAVI) who had vasculitic ulcers and systemic inflammation refractory to Janus kinase inhibition (JAKi).
{"title":"Sustained IFN Signature Suppression with Anifrolumab in a SAVI patient Refractory to JAK Inhibitor and Dazukibart Therapy","authors":"Sara Alehashemi, Bjoern Buehring, Adriana A de Jesus, Sachin Gaurav, Andre Rastegar, Alexi Baumgardner, Kip Friend, Oluwatobi T. Arisa, William D. Figg, Danielle Fink, Douglas B. Kuhns, Ben Colton, Cody J Peer, Raphaela Goldbach-Mansky","doi":"10.1002/art.43145","DOIUrl":"https://doi.org/10.1002/art.43145","url":null,"abstract":"To report the efficacy and safety of interferon-β (IFNβ) neutralizing monoclonal antibody (dazukibart), followed by treatment with anti-IFNAR1 antibody (anifrolumab), in a patient with STING-associated vasculopathy with onset in infancy (SAVI) who had vasculitic ulcers and systemic inflammation refractory to Janus kinase inhibition (JAKi).","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"32 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zijian Kang, Jianzheng Zhang, Wenxin Liu, Chen Zhu, Ying Zhu, Ping Li, Kai Li, Qiang Tong, Sheng-Ming Dai
Osteoarthritis (OA) is a widespread degenerative joint disease that causes a considerable socioeconomic burden. Despite progress in genetic and environmental insights, early diagnosis is still limited by the lack of evident symptoms during the initial phases and accurate biomarkers. This study aims to identify plasma proteins associated with future risk of OA and develop a predictive model.
{"title":"Plasma proteomic profiles predict individual future osteoarthritis risk","authors":"Zijian Kang, Jianzheng Zhang, Wenxin Liu, Chen Zhu, Ying Zhu, Ping Li, Kai Li, Qiang Tong, Sheng-Ming Dai","doi":"10.1002/art.43143","DOIUrl":"https://doi.org/10.1002/art.43143","url":null,"abstract":"Osteoarthritis (OA) is a widespread degenerative joint disease that causes a considerable socioeconomic burden. Despite progress in genetic and environmental insights, early diagnosis is still limited by the lack of evident symptoms during the initial phases and accurate biomarkers. This study aims to identify plasma proteins associated with future risk of OA and develop a predictive model.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"4 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vanessa L. Kronzer, Yangyuna Yang, Punyasha Roul, James L. Crooks, Cynthia S. Crowson, John M. Davis, Jeffrey A. Sparks, Jeffrey R. Pierce, Katelyn O'Dell, Brian C. Sauer, Grant W. Cannon, Joshua F. Baker, Ted R. Mikuls, Bryant R. England
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{"title":"Associations of fire smoke and other pollutants with incident rheumatoid arthritis and rheumatoid arthritis associated interstitial lung disease: reply","authors":"Vanessa L. Kronzer, Yangyuna Yang, Punyasha Roul, James L. Crooks, Cynthia S. Crowson, John M. Davis, Jeffrey A. Sparks, Jeffrey R. Pierce, Katelyn O'Dell, Brian C. Sauer, Grant W. Cannon, Joshua F. Baker, Ted R. Mikuls, Bryant R. England","doi":"10.1002/art.43142","DOIUrl":"https://doi.org/10.1002/art.43142","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"65 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Efficacy and Safety of SGLT2 Inhibitors in Preventing Cardiovascular and Renal Events in Patients with Systemic Lupus Erythematosus and Type 2 Diabetes Mellitus","authors":"Zichang Liu, Yanwei Zhu, Hui Zhao","doi":"10.1002/art.43138","DOIUrl":"https://doi.org/10.1002/art.43138","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"27 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Associations of fire smoke and other pollutants with incident rheumatoid arthritis and rheumatoid arthritis-associated interstitial lung disease: comment on the article by Kronzer VL et al","authors":"Gang Wang, Zhichun Liu","doi":"10.1002/art.43141","DOIUrl":"https://doi.org/10.1002/art.43141","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"51 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katherine A. Yates, Carolina Alvarez, Todd A. Schwartz, Serena Savage-Guin, Jordan B. Renner, Catherine J. Bakewell, Minna J. Kohler, Janice Lin, Jonathan Samuels, Tessa Walker, Yvonne M. Golightly, Amanda E. Nelson
To determine 1) associations among ultrasound (US) features of knee osteoarthritis (KOA), radiographic KOA (rKOA), and patient-reported symptoms, and 2) diagnostic accuracy of US definitions for rKOA, in a community-based cohort.
{"title":"Associations and Diagnostic Accuracy of Ultrasound Features in Knee Osteoarthritis: Cross-sectional Results from a Large Community-based Cohort","authors":"Katherine A. Yates, Carolina Alvarez, Todd A. Schwartz, Serena Savage-Guin, Jordan B. Renner, Catherine J. Bakewell, Minna J. Kohler, Janice Lin, Jonathan Samuels, Tessa Walker, Yvonne M. Golightly, Amanda E. Nelson","doi":"10.1002/art.43139","DOIUrl":"https://doi.org/10.1002/art.43139","url":null,"abstract":"To determine 1) associations among ultrasound (US) features of knee osteoarthritis (KOA), radiographic KOA (rKOA), and patient-reported symptoms, and 2) diagnostic accuracy of US definitions for rKOA, in a community-based cohort.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"14 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martina Uzzo, Helmut Schumacher, Juergen Steffgen, Simone Deutschel, David Jayne, Ingeborg Bajema
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{"title":"Authors’ reply to Zhou et al.","authors":"Martina Uzzo, Helmut Schumacher, Juergen Steffgen, Simone Deutschel, David Jayne, Ingeborg Bajema","doi":"10.1002/art.43134","DOIUrl":"https://doi.org/10.1002/art.43134","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"64 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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