Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Monika Hansson, Nasim Ghasemzadeh, Jessica Rojas-Restrepo, Saedis Saevarsdottir, Joe Sexton, Siri Lillegraven, Espen Haavardsholm, Bente Glintborg, Hilde Berner Hammer, Tore K. Kvien, Merete Lund Hetland, Leonid Padyukov, , Johan Askling, Caroline Grönwall
Rheumatoid arthritis (RA) associated anti-citrullinated protein antibodies (ACPA) target various antigens by binding short citrulline-amino acid motifs, resulting in heterogeneous ACPA-profiles among patients. Here we analyzed ACPA-patterns by recognized citrulline-motifs in relation to the RA risk factors HLA-DRB1 shared epitope (SE) alleles and history of smoking.
{"title":"Recognition of glycine versus non-glycine citrulline motifs dictates the HLA class II association of anti-citrullinated protein antibodies - insights from autoantibody profiling of 6900 Scandinavian rheumatoid arthritis patients","authors":"Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Monika Hansson, Nasim Ghasemzadeh, Jessica Rojas-Restrepo, Saedis Saevarsdottir, Joe Sexton, Siri Lillegraven, Espen Haavardsholm, Bente Glintborg, Hilde Berner Hammer, Tore K. Kvien, Merete Lund Hetland, Leonid Padyukov, , Johan Askling, Caroline Grönwall","doi":"10.1002/art.43161","DOIUrl":"https://doi.org/10.1002/art.43161","url":null,"abstract":"Rheumatoid arthritis (RA) associated anti-citrullinated protein antibodies (ACPA) target various antigens by binding short citrulline-amino acid motifs, resulting in heterogeneous ACPA-profiles among patients. Here we analyzed ACPA-patterns by recognized citrulline-motifs in relation to the RA risk factors HLA-DRB1 shared epitope (SE) alleles and history of smoking.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"183 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond Joint Pain – Expanding Insights on the Impact of Nonarticular Pain in Early Rheumatoid Arthritis","authors":"Yumei Zhong, Rui Lai, Xinmin Deng","doi":"10.1002/art.43160","DOIUrl":"https://doi.org/10.1002/art.43160","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"101 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qianlin Weng, Ting Jiang, Tuo Yang, Yuqing Zhang, Weiya Zhang, Michael Doherty, Jie Wei, Yilun Wang, Guanghua Lei, Chao Zeng
Intramuscular fat infiltration (IMFI) in the thigh is linked to metabolic inflammation and muscle dysfunction, which could contribute to osteoarthritis development. However, no longitudinal studies have examined the associations between thigh IMFI and incident knee and hip osteoarthritis.
{"title":"Association of thigh intramuscular fat infiltration with incident knee and hip osteoarthritis: a longitudinal cohort study","authors":"Qianlin Weng, Ting Jiang, Tuo Yang, Yuqing Zhang, Weiya Zhang, Michael Doherty, Jie Wei, Yilun Wang, Guanghua Lei, Chao Zeng","doi":"10.1002/art.43159","DOIUrl":"https://doi.org/10.1002/art.43159","url":null,"abstract":"Intramuscular fat infiltration (IMFI) in the thigh is linked to metabolic inflammation and muscle dysfunction, which could contribute to osteoarthritis development. However, no longitudinal studies have examined the associations between thigh IMFI and incident knee and hip osteoarthritis.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"61 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charles L Bennett, Jason B Gibbons, Chadi Nabhan, Kenneth R Carson, June M McKoy, Kevin B Knopf, Gerald Anderson
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{"title":"Notes from the field: The Inflation Reduction Act and Enbrel","authors":"Charles L Bennett, Jason B Gibbons, Chadi Nabhan, Kenneth R Carson, June M McKoy, Kevin B Knopf, Gerald Anderson","doi":"10.1002/art.43153","DOIUrl":"https://doi.org/10.1002/art.43153","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"33 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ki Pui Lam, Claudia Harris, Maria L Taylor, Daniela Fernandez-Salinas, Jing Cui, Biju Issac, Liang Sun, Indu Raman, Chengsong Zhu, Maryrose Hahn, Maryam Ashoor, Ahmad Bakhsh, Maria C Bryant, Siobhan Case, Mia Chandler, Joyce C Chang, Ezra Cohen, Fatma Dedeoglu, Olha Halyabar, Jonathan S Hausmann, Melissa Hazen, Daniel Ibanez, Liyoung Kim, Jeffrey Lo, Mindy S Lo, Esra Meidan, Megan Perron, Helene Powers, Mary Beth Son, Holly Wobma, Erin Janssen, Pui Y Lee, Peter A Nigrovic, Laurie Ohlms, A Eliot Shearer, Margaret H Chang, Maria Gutierrez-Arcelus, Lauren A Henderson
Disordered T peripheral helper (Tph)-B cell interactions have been implicated in several forms of inflammatory arthritis, including oligoarticular juvenile idiopathic arthritis (oligo JIA). We sought to evaluate the Tph-B cell axis in oligo JIA through an analysis of intra-articular B cells.
{"title":"Sex Differences in B Cells from the Joints of Children with Oligoarticular Juvenile Idiopathic Arthritis","authors":"Ki Pui Lam, Claudia Harris, Maria L Taylor, Daniela Fernandez-Salinas, Jing Cui, Biju Issac, Liang Sun, Indu Raman, Chengsong Zhu, Maryrose Hahn, Maryam Ashoor, Ahmad Bakhsh, Maria C Bryant, Siobhan Case, Mia Chandler, Joyce C Chang, Ezra Cohen, Fatma Dedeoglu, Olha Halyabar, Jonathan S Hausmann, Melissa Hazen, Daniel Ibanez, Liyoung Kim, Jeffrey Lo, Mindy S Lo, Esra Meidan, Megan Perron, Helene Powers, Mary Beth Son, Holly Wobma, Erin Janssen, Pui Y Lee, Peter A Nigrovic, Laurie Ohlms, A Eliot Shearer, Margaret H Chang, Maria Gutierrez-Arcelus, Lauren A Henderson","doi":"10.1002/art.43157","DOIUrl":"https://doi.org/10.1002/art.43157","url":null,"abstract":"Disordered T peripheral helper (Tph)-B cell interactions have been implicated in several forms of inflammatory arthritis, including oligoarticular juvenile idiopathic arthritis (oligo JIA). We sought to evaluate the Tph-B cell axis in oligo JIA through an analysis of intra-articular B cells.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"24 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tuhina Neogi, Maureen Dubreuil, Christine Peloquin, Lee Marinko, James Camarinos, David T. Felson, Deepak Kumar
To assess the relation of physical therapy (PT) timing, dose, and type with risk of future intra-articular therapy use in people with knee osteoarthritis (OA) who receive PT.
评估接受物理治疗（PT）的时间、剂量和类型与膝关节骨性关节炎（OA）患者未来关节内治疗风险的关系。
{"title":"Association of physical therapy care with utilization of intra-articular injections in people with knee osteoarthritis: a real-world cohort study","authors":"Tuhina Neogi, Maureen Dubreuil, Christine Peloquin, Lee Marinko, James Camarinos, David T. Felson, Deepak Kumar","doi":"10.1002/art.43155","DOIUrl":"https://doi.org/10.1002/art.43155","url":null,"abstract":"To assess the relation of physical therapy (PT) timing, dose, and type with risk of future intra-articular therapy use in people with knee osteoarthritis (OA) who receive PT.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"16 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yingzhao Jin, Isaac T Cheng, Ho So, Billy T Lai, Shirley K. Ying, Kitty Y. Kwok, James Griffith, Vivian Hung, Cheuk-Chun Szeto, Jack J. Lee, Ling Qin, Lai-Shan Tam
This study aimed to ascertain the effect of secukinumab on erosion and enthesiophyte progression in psoriatic arthritis (PsA) by high-resolution peripheral quantitative computed tomography (HR-pQCT).
{"title":"Effects of secukinumab on enthesiophyte and erosion progression in psoriatic arthritis –a one-year double-blind, randomized, placebo-controlled trial utilizing high-resolution peripheral quantitative computed tomography","authors":"Yingzhao Jin, Isaac T Cheng, Ho So, Billy T Lai, Shirley K. Ying, Kitty Y. Kwok, James Griffith, Vivian Hung, Cheuk-Chun Szeto, Jack J. Lee, Ling Qin, Lai-Shan Tam","doi":"10.1002/art.43154","DOIUrl":"https://doi.org/10.1002/art.43154","url":null,"abstract":"This study aimed to ascertain the effect of secukinumab on erosion and enthesiophyte progression in psoriatic arthritis (PsA) by high-resolution peripheral quantitative computed tomography (HR-pQCT).","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"23 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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