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Revision rate following unipolar versus bipolar hemiarthroplasty. 单极与双极半关节成形术后的翻修率。
IF 1.3 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-07-01 Epub Date: 2024-03-14 DOI: 10.1177/11207000241235394
David Kugelman, Joseph X Robin, Benjamin C Schaffler, Roy Davidovitch, Kenneth Egol, Ran Schwarzkopf

Introduction: There has been much debate on use of bipolar or unipolar femoral heads in hemiarthroplasty for the treatment of femoral neck fractures. The outcome of these implants should be studied in the America Joint Replacement Registry (AJRR).

Methods: All primary femoral neck fractures treated with hemiarthroplasty between January 2012 and June 2020 were searched in the AJRR. All cause-revision of unipolar and bipolar hemiarthroplasty and reasons for revision were assessed for these patients until June of 2023.

Results: There were no differences in number and reason for all cause revisions between unipolar and bipolar hemiarthroplasty (p= 0.41). Bipolar hemiarthroplasty had more revisons at 6 months postoperatively (p= 0.0281), but unipolar hemiarthroplasty had more revisions between 2 and 3 years (p= 0.0003), and after 3-years (p= 0.0085), as analysed with a Cox model. Patients with older age (HR = 0.999; 95% CI, 0.998-0.999; p= 0.0006) and higher Charlson Comorbidity Index (HR = 0.996; 95% CI, 0.992- 0.999; p= 0.0192) had a significant increase in revision risk.

Conclusions: We suggest that surgeons should consider using bipolar prosthesis when performing hemiarthroplasty for femoral neck fracture in patients expected to live >2 years post injury.

导言:关于在半关节成形术中使用双极或单极股骨头治疗股骨颈骨折的问题一直争论不休。美国关节置换登记处(AJRR)应对这些植入物的效果进行研究:方法:在美国关节置换登记处检索了2012年1月至2020年6月期间所有采用半关节置换术治疗的原发性股骨颈骨折。结果:截至 2023 年 6 月,对这些患者的单极和双极半关节成形术的所有翻修原因和翻修原因进行了评估:结果:单极和双极半关节成形术的所有原因翻修次数和原因均无差异(P = 0.41)。根据Cox模型分析,双极半关节成形术术后6个月的翻修率更高(p = 0.0281),但单极半关节成形术术后2至3年的翻修率更高(p = 0.0003),3年后的翻修率更高(p = 0.0085)。年龄较大(HR = 0.999; 95% CI, 0.998-0.999; p = 0.0006)和Charlson合并症指数较高(HR = 0.996; 95% CI, 0.992- 0.999; p = 0.0192)的患者翻修风险显著增加:我们建议外科医生在为预计伤后存活时间超过2年的股骨颈骨折患者实施半关节置换术时,应考虑使用双极假体。
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引用次数: 0
"Stuck in the middle": the missing lumbosacral link in total hip arthroplasty. "卡在中间":全髋关节置换术中缺失的腰骶部环节。
IF 1.3 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-07-01 Epub Date: 2024-03-12 DOI: 10.1177/11207000231223706
Christopher M Scanlon, Thomas Christensen, Thomas Bieganowski, Weston Buehring, Morteza Meftah, Matthew S Hepinstall

Introduction: Spinopelvic mobility drives functional acetabular position, influencing dislocation risk after total hip arthroplasty (THA). Patients have been described as "stuck sitting" or "stuck standing" based on pelvic tilt (PT). We hypothesised that some patients are "stuck in the middle," meaning their PT changes minimally from sitting to standing - increasing their risk of dislocation.

Methods: We reviewed 195 patients with standing and sitting whole body radiographs prior to THA. Standing anterior pelvic plane tilt (APPT) and standing and sitting sacral slope (SS) were measured and used to calculate sitting APPT. Normal standing and sitting were defined as APPT >-10° and <-20°, respectively. Spinal stiffness was classified as <10° change in sacral slope between sitting and standing. Patients were categorised as: (A) able to fully sit and stand; (B) "stuck sitting" - able to fully sit; unable to fully stand; (C) "stuck standing" - able to fully stand; unable to fully sit; or (D) "stuck in the middle" - unable to sit or stand fully.

Results: 84 patients could sit and stand normally (A), 22 patients were stuck sitting (B), 76 patients were stuck standing (C), and 13 patients were stuck in the middle (D). While 111 patients (56.9%) were considered stuck, only 58 patients (29.7%) met criteria for spinal stiffness.

Discussion: We identified a subset of patients with stiff spines and abnormal PT in both sitting and standing, including 37.1% of patients who would be classified as "stuck sitting" based only on standing radiographs. Placing acetabular components in less than anatomic anteversion in these patients may increase posterior dislocation risk.

简介:脊柱骨盆的活动度会影响髋臼的功能位置,从而影响全髋关节置换术(THA)后的脱位风险。根据骨盆倾斜度(PT),患者被描述为 "坐姿卡住 "或 "站姿卡住"。我们假设一些患者 "卡在中间",即从坐姿到站姿,他们的骨盆倾斜度变化很小,这增加了他们脱位的风险:我们对 195 名患者在接受全髋关节置换术前的站立和坐位全身X光片进行了复查。我们测量了站立时骨盆前平面倾斜(APPT)以及站立和坐位时的骶骨斜度(SS),并将其用于计算坐位时的APPT。正常站姿和坐姿的定义是 APPT >-10° 和 结果:84名患者可以正常坐立(A),22名患者坐姿受限(B),76名患者站姿受限(C),13名患者站姿受限(D)。虽然有 111 名患者(56.9%)被认为脊柱僵硬,但只有 58 名患者(29.7%)符合脊柱僵硬的标准:讨论:我们发现了一部分患者脊柱僵硬,坐姿和站姿的PT均异常,其中37.1%的患者仅根据站姿X光片就被归类为 "坐姿卡住"。将髋臼组件置于这些患者的解剖内翻位可能会增加后脱位风险。
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引用次数: 0
Does-dual mobility still offer improved stability in smaller cup sizes? A computer modelling comparison of stability with 22-mm versus 28-mm inner heads in dual-mobility versus single-bearing constructs. 双活动度是否仍能提高较小罩杯的稳定性?通过计算机建模比较双活动度与单承托结构中 22 毫米与 28 毫米内杯头的稳定性。
IF 1.3 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-07-01 Epub Date: 2024-02-19 DOI: 10.1177/11207000231220031
Amit Atrey, Alessandro Navacchia, Sarah E Ward, David Rister, Jacqueline Brillantes, Alexandra Stavrakis, Amir Khoshbin

Purpose: Dislocation remains 1 of the leading causes of revision after primary total hip arthroplasty (THA) and there is clear evidence the dual-mobility (DM) is used more frequently to minimise this. But in smaller cups, whether the use of DM with smaller 22-mm heads imparts any increased stability compared to standard bearing is unknown; especially when those smaller cups now allow for large single-bearing (SB) heads.

Methods: 3 primary cup sizes (48 mm, 50 mm, 52 mm) were chosen a priori for modelling. Head sizes trialled for the standard bearing (SB) constructs group were 28-0 mm, 32-0 mm and 36-0 mm against neutral polyethylene liners. In the modular sub-hemispheric DM constructs the inner head sizes for the DM constructs were altered where appropriate (22-0 mm vs. 28-0 mm). Cup position, stem offset, and stem size were standardised.

Results: Both DM constructs outperformed all SB constructs because of a statistically significant jump distance increase (p < 0.001). However, there was no difference in range of motion (ROM) or jump distances between the 22-mm and 28-mm DM inner heads.The ROM angle before impingement between the DM (with 22-mm or 28-mm heads) and SB (with different head sizes where appropriate) showed no statistically significant difference. However, DM constructs presented significantly larger jump distances than SB constructs for both provocative dislocation tests across all 3 cup sizes.Of interest, for 50-mm and 52-mm cup sizes (for which this particular DM construct design can accommodate both 22-mm and 28-mm inner heads), there were no differences in ROM or jump distance between 22-mm versus 28-mm inner heads.

Conclusions: In this computer-modelling study, DM constructs are advantageous over SB constructs for improving jump distances in clinically provocative positions, but not range of motion angles. Inner head diameter of DM has no effect on stability.

目的:脱位仍是初次全髋关节置换术(THA)后翻修的主要原因之一,有明显证据表明,双活动度(DM)的使用频率更高,可最大限度地减少脱位。但在较小的髋臼杯中,与标准轴承相比,使用较小的 22 毫米头的 DM 是否会增加稳定性,目前尚不清楚;尤其是在较小的髋臼杯现在允许使用较大的单轴承(SB)头的情况下。方法:事先选择 3 种主要髋臼杯尺寸(48 毫米、50 毫米、52 毫米)进行建模。在标准轴承(SB)结构组中,针对中性聚乙烯内衬试用的头颅尺寸分别为 28-0毫米、32-0 毫米和 36-0毫米。在模块化次半球DM结构中,DM结构的内侧头尺寸酌情改变(22-0毫米与28-0毫米)。髋臼杯位置、茎杆偏移量和茎杆尺寸均已标准化:结果:两种 DM 构型都优于所有 SB 构型,因为在统计意义上,两者的跳跃距离都有显著增加(p 结论:DM 构型和 SB 构型的跳跃距离都有显著增加:在这项计算机建模研究中,DM结构比SB结构更有利于提高临床刺激体位的跳跃距离,但对运动角度范围没有影响。DM 头的内径对稳定性没有影响。
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引用次数: 0
Extra-articular hip resection with maintenance of pelvic continuity in malignant tumours of the proximal femur with articular invasion. 股骨近端恶性肿瘤伴关节侵犯时的关节外髋关节切除术与骨盆连续性的保持。
IF 1.3 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-07-01 Epub Date: 2024-05-08 DOI: 10.1177/11207000241249135
Guillaume-Anthony Odri, Cédric Yatim, Diane Ji Yun Yoon, Pierre-Alban Bouche, Mathieu Severyns, Pascal Bizot

Introduction: Extra-articular hip resection may be necessary in cases of malignant tumour of the pelvic bone or of the proximal femur invading the hip joint. When the tumour is in the proximal femur, it is possible to resect the acetabulum en bloc by performing a periacetabular osteotomy, but this creates a discontinuity in the pelvic ring with difficult reconstruction and diminished function. Several techniques described recently seek to be as sparing as possible on the pelvic bone by preserving the posterior column or both columns in order to facilitate reconstruction and improve function. However, these still require complex reconstructions and can necessitate intra-pelvic dissection.

Technique: We describe here an extra-articular hip resection technique for tumours of the proximal femur invading the joint, with maintenance of pelvic continuity by preserving both columns and the quadrilateral plate of the acetabulum, without intra-pelvic dissection, that can be performed on patients in whom the medial wall of the acetabulum is thick enough. Our preliminary assessments have included studies on dry bone and imaging analyses. The technique was first tested on a single cadaver pelvis (encompassing 2 hips) and subsequently performed on a patient with a pathological fracture of the femoral neck due to osteosarcoma secondary to Paget's disease.

Conclusions: Further clinical applications are essential to evaluate the overall effectiveness, safety and impact on patient functionality of this experimental technique.

导言:盆骨或股骨近端恶性肿瘤侵犯髋关节时,可能需要进行髋关节外切除术。当肿瘤位于股骨近端时,可以通过髋臼周围截骨术对髋臼进行整体切除,但这会造成骨盆环的不连续性,导致重建困难和功能减退。最近介绍的几种技术试图通过保留后柱或双柱来尽可能保留骨盆骨,以方便重建和改善功能。然而,这些技术仍然需要复杂的重建,并可能需要进行骨盆内剥离:我们在此介绍一种针对侵犯关节的股骨近端肿瘤的关节外髋关节切除技术,该技术通过保留髋臼的两根支柱和四边形骨板来保持骨盆的连续性,无需骨盆内剥离,适用于髋臼内侧壁足够厚的患者。我们的初步评估包括干骨研究和成像分析。该技术首先在一个尸体骨盆(包括两个髋关节)上进行了测试,随后在一名因继发于帕吉特氏病的骨肉瘤而导致股骨颈病理性骨折的患者身上进行了测试:进一步的临床应用对于评估该实验技术的整体有效性、安全性和对患者功能的影响至关重要。
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引用次数: 0
Inflammatory bowel disease patients undergoing total hip arthroplasty have higher odds of implant-related complications. 接受全髋关节置换术的炎症性肠病患者出现植入相关并发症的几率更高。
IF 1.3 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-07-01 Epub Date: 2023-12-12 DOI: 10.1177/11207000231214768
Matthew L Magruder, Shabnam Parsa, Adam M Gordon, Mitchell Ng, Che Hang J Wong

Purpose: This study evaluates whether IBD patients are at increased risk of implant-related complications after THA.

Materials and methods: A retrospective study from 01 January 2010 to 31 October 31 2020 using an administrative claims database was performed. IBD patients undergoing THA (n = 11,025), without corticosteroid treatment, were propensity score matched to controls in a 1:5 ratio (n = 55,121) based on age, sex, and the Charlson Comorbidity Index (CCI). Outcomes evaluated included periprosthetic fracture, aseptic loosening, prosthetic joint infection, and THA revision within 2 years of index procedure. Chi-square analyses were used to compare the matched cohorts. The association of IBD and implant-related complications was evaluated using logistical regression to calculate odds ratios (ORs), 95% confidence intervals (95% CIs), and p-values. A p-value < 0.001 was used as the significance threshold.

Results: Patients with IBD had a greater incidence and odds of total implant complications (7.03% vs. 3.98%; OR 1.76; p < 0.001) compared with matched controls. IBD patients had significantly higher incidence and odds of developing periprosthetic fracture (0.50% vs. 0.20%; OR 2.46; p < 0.001), THA revisions (2.21% vs. 1.17%; OR 1.91; p < 0.001), aseptic loosening (1.45% vs. 0.84%; OR 1.75; p < 0.001), and prosthetic joint infection (2.87% vs. 1.77%; OR 1.64; p < 0.001).

Conclusions: Patients with IBD who underwent primary THA had a significantly higher risk of implant-related complications compared to matched controls. Providers should use this study to appropriately assess post-complication risk factors for their patients with IBD.

目的:本研究评估了 IBD 患者在 THA 术后是否会增加植入相关并发症的风险:利用行政索赔数据库对 2010 年 1 月 1 日至 2020 年 10 月 31 日期间的情况进行了回顾性研究。根据年龄、性别和夏尔森综合症指数(CCI),接受 THA 手术的 IBD 患者(n = 11,025 例)在未接受皮质类固醇治疗的情况下,与对照组(n = 55,121 例)按 1:5 的比例进行倾向评分匹配。评估的结果包括假体周围骨折、无菌性松动、假体关节感染以及指数手术后 2 年内的 THA 翻修。采用卡方分析比较配对队列。使用逻辑回归法评估了 IBD 与植入相关并发症的关系,计算出了几率比 (OR)、95% 置信区间 (95% CI) 和 p 值。A p值 结果:IBD 患者出现种植体总并发症的发生率和几率更高(7.03% vs. 3.98%; OR 1.76; p p p p p 结论:与匹配的对照组相比,接受初级 THA 的 IBD 患者发生植入相关并发症的风险明显更高。医疗机构应利用这项研究来适当评估 IBD 患者并发症后的风险因素。
{"title":"Inflammatory bowel disease patients undergoing total hip arthroplasty have higher odds of implant-related complications.","authors":"Matthew L Magruder, Shabnam Parsa, Adam M Gordon, Mitchell Ng, Che Hang J Wong","doi":"10.1177/11207000231214768","DOIUrl":"10.1177/11207000231214768","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluates whether IBD patients are at increased risk of implant-related complications after THA.</p><p><strong>Materials and methods: </strong>A retrospective study from 01 January 2010 to 31 October 31 2020 using an administrative claims database was performed. IBD patients undergoing THA (<i>n</i> = 11,025), without corticosteroid treatment, were propensity score matched to controls in a 1:5 ratio (<i>n</i> = 55,121) based on age, sex, and the Charlson Comorbidity Index (CCI). Outcomes evaluated included periprosthetic fracture, aseptic loosening, prosthetic joint infection, and THA revision within 2 years of index procedure. Chi-square analyses were used to compare the matched cohorts. The association of IBD and implant-related complications was evaluated using logistical regression to calculate odds ratios (ORs), 95% confidence intervals (95% CIs), and <i>p</i>-values. A <i>p-</i>value < 0.001 was used as the significance threshold.</p><p><strong>Results: </strong>Patients with IBD had a greater incidence and odds of total implant complications (7.03% vs. 3.98%; OR 1.76; <i>p</i> < 0.001) compared with matched controls. IBD patients had significantly higher incidence and odds of developing periprosthetic fracture (0.50% vs. 0.20%; OR 2.46; <i>p</i> < 0.001), THA revisions (2.21% vs. 1.17%; OR 1.91; <i>p</i> < 0.001), aseptic loosening (1.45% vs. 0.84%; OR 1.75; <i>p</i> < 0.001), and prosthetic joint infection (2.87% vs. 1.77%; OR 1.64; <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Patients with IBD who underwent primary THA had a significantly higher risk of implant-related complications compared to matched controls. Providers should use this study to appropriately assess post-complication risk factors for their patients with IBD.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"498-502"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The accuracy and diagnostic value of gram staining joint aspirates in suspected joint infections. 对疑似关节感染的关节抽吸物进行革兰氏染色的准确性和诊断价值。
IF 1.3 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-07-01 Epub Date: 2024-02-27 DOI: 10.1177/11207000241230927
James Zhang, Anna Stevenson, Andrew Kailin Zhou, Faris Khan, Rahul Geetala, Matija Krkovic

Background: Septic arthritis is a debilitating condition with prolonged treatment and adverse outcomes. A gram stain is often performed from the joint aspirate sample, followed by a definitive culture. In our study, we assessed the accuracy of gram staining for suspected septic arthritis and explored factors associated with positive culture growth and false negatives in the gram stain.

Methods: We retrospectively reviewed joint aspirates performed from 2015-2021 at a major trauma centre. Aspirates not cultured for septic arthritis were excluded. Data collected included aspirate site, gram stain and culture result delay, patient demographics, orthopaedic/rheumatological history, and comorbidities. Outcomes measured were gram stain sensitivity and specificity. Factors influencing positive cultures and false negative gram stain results were analysed using logistic regression.

Results: Of 408 joint aspirates meeting the criteria, 37 did not undergo initial gram staining. Gram stain sensitivity was 30.4%, specificity was 97.6%. The delay from aspirate to definitive gram stain and culture results was 1.1 and 5.4 days, respectively Logistic regression identified that prosthetic joint(p = 0.007), past joint infections(p = 0.006), arthritis(p < 0.001), hypertension(p = 0.007), diabetes(p = 0.019) were positively associated with positive cultures. Past joint infections(p = 0.004) were positively associated with false negative gram stain results. Patients on antibiotics during the aspirate had a higher risk of false negative gram stain results (OR = 5.538, 95%CI, 2.802-10.948; p < 0.001).

Conclusions: In conclusion, the initial gram stain has limited sensitivity and caution should be exercised when interpreting negative results. Vigilance is crucial when the highlighted comorbidities or antibiotic use are present, to assess patients with potential joint infections.

背景:化脓性关节炎是一种使人衰弱的疾病,治疗时间长,结果不良。通常先对关节抽吸样本进行革兰氏染色,然后进行确证培养。在我们的研究中,我们评估了对疑似化脓性关节炎进行革兰氏染色的准确性,并探讨了与革兰氏染色培养阳性生长和假阴性相关的因素:我们对一家大型创伤中心 2015-2021 年期间进行的关节穿刺进行了回顾性分析。未培养出化脓性关节炎的抽吸物被排除在外。收集的数据包括抽吸部位、革兰氏染色和培养结果延迟、患者人口统计学、骨科/风湿病史和合并症。测量结果为革兰氏染色敏感性和特异性。采用逻辑回归分析了影响阳性培养和假阴性革兰氏染色结果的因素:在符合标准的 408 例关节抽吸物中,37 例未进行初步革兰氏染色。革兰氏染色敏感性为 30.4%,特异性为 97.6%。逻辑回归结果显示,假肢关节(p = 0.007)、既往关节感染(p = 0.006)、关节炎(p = 0.007)、糖尿病(p = 0.019)与阳性培养呈正相关。既往关节感染(p = 0.004)与革兰氏染色假阴性结果呈正相关。在抽吸过程中使用抗生素的患者出现革兰氏染色假阴性结果的风险较高(OR = 5.538,95%CI,2.802-10.948;p):总之,初始革兰氏染色的灵敏度有限,在解释阴性结果时应谨慎。当存在突出的合并症或使用抗生素时,必须保持警惕,以评估潜在的关节感染患者。
{"title":"The accuracy and diagnostic value of gram staining joint aspirates in suspected joint infections.","authors":"James Zhang, Anna Stevenson, Andrew Kailin Zhou, Faris Khan, Rahul Geetala, Matija Krkovic","doi":"10.1177/11207000241230927","DOIUrl":"10.1177/11207000241230927","url":null,"abstract":"<p><strong>Background: </strong>Septic arthritis is a debilitating condition with prolonged treatment and adverse outcomes. A gram stain is often performed from the joint aspirate sample, followed by a definitive culture. In our study, we assessed the accuracy of gram staining for suspected septic arthritis and explored factors associated with positive culture growth and false negatives in the gram stain.</p><p><strong>Methods: </strong>We retrospectively reviewed joint aspirates performed from 2015-2021 at a major trauma centre. Aspirates not cultured for septic arthritis were excluded. Data collected included aspirate site, gram stain and culture result delay, patient demographics, orthopaedic/rheumatological history, and comorbidities. Outcomes measured were gram stain sensitivity and specificity. Factors influencing positive cultures and false negative gram stain results were analysed using logistic regression.</p><p><strong>Results: </strong>Of 408 joint aspirates meeting the criteria, 37 did not undergo initial gram staining. Gram stain sensitivity was 30.4%, specificity was 97.6%. The delay from aspirate to definitive gram stain and culture results was 1.1 and 5.4 days, respectively Logistic regression identified that prosthetic joint(<i>p</i> = 0.007), past joint infections(<i>p</i> = 0.006), arthritis(<i>p</i> < 0.001), hypertension(<i>p</i> = 0.007), diabetes(<i>p</i> = 0.019) were positively associated with positive cultures. Past joint infections(<i>p</i> = 0.004) were positively associated with false negative gram stain results. Patients on antibiotics during the aspirate had a higher risk of false negative gram stain results (OR = 5.538, 95%CI, 2.802-10.948; <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>In conclusion, the initial gram stain has limited sensitivity and caution should be exercised when interpreting negative results. Vigilance is crucial when the highlighted comorbidities or antibiotic use are present, to assess patients with potential joint infections.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"546-552"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term follow-up of total hip arthroplasty using polyethylene-ceramic composite (sandwich) liner. 使用聚乙烯-陶瓷复合材料(三明治)衬垫的全髋关节置换术的长期随访。
IF 1.3 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-07-01 Epub Date: 2024-03-26 DOI: 10.1177/11207000241239624
Daniel Rodríguez-Pérez, Thiago Carnaval, Marcos-Del-Carmen Rodríguez, Antonio Coscujuela-Maña, José-Luis Agulló, Sebastián Videla

Introduction: Ceramic-on-ceramic bearings have been widely used since their introduction in the 1970s. First-generation ceramics have very high fracture (breakage) rates. To overcome this, in the 1990s, modular cotyloid insert designs were developed, consisting of a ceramic and polyethylene composite (sandwich-type) liner; however, high implant fracture rates were observed in the medium term. We aimed to estimate the cumulative incidences of revision surgery (implant failure) and implant failure due to fractures, survival rates (time-to-revision surgery and time-to-fracture), and the long-term clinical and radiological outcomes in our series.

Methods: This was an observational, longitudinal, ambispective, single-centre study based on patients who underwent primary total hip arthroplasty (THA) using a sandwich-type liner (Cerasul), only available in our tertiary hospital between January 1999 and December 2002. Cumulative incidences were estimated and the 95% confidence interval (95% CI) was calculated. The Kaplan-Meier method was used to assess the time-to-revision surgery and time-to-fracture.

Results: 54 patients (49 men) were included, accounting for 59 sandwich-type linear implants. The mean (range) age was 47.4 (22-57) years. The primary THA indications were osteoarthritis (28 patients), osteonecrosis (14), childhood pathology sequelae (11), and inflammatory arthritis (6). The cumulative incidence of revision surgery by implants was 8.5% (5/59, 95% CI, 3.5-19.2%), 9.3% by patients (5/54, 95% CI, 4.0-19.9%), and 5.1% by implant fractures (3/59, 95%CI, 1.7-13.9%). The median (Interquartile Range, IQR) time-to-revision surgery was 158 (72.5-161) months, and the time to fracture was 182 (138-215) months. All primary THAs had good clinical and long-term survival outcomes. All implants had signs of solid fixation.

Conclusions: After a 20-year follow-up period, the polyethylene-ceramic sandwich-type liner showed a long survival rate and low cumulative incidence of implant fracture; however, implant fractures remain the main complication. Orthopaedic surgeons should be aware that some patients still have this type of prosthesis and must be capable of responding quickly if a fracture occurs.

简介:自 20 世纪 70 年代问世以来,陶瓷轴承已得到广泛应用。第一代陶瓷的断裂(破损)率非常高。为了克服这一问题,20 世纪 90 年代,开发出了由陶瓷和聚乙烯复合材料(夹层型)衬垫组成的模块化楔形衬垫设计。我们的目的是估算翻修手术(植入失败)和骨折导致的植入失败的累积发生率、存活率(翻修手术时间和骨折时间)以及我们系列研究的长期临床和放射学结果:这是一项观察性、纵向、前瞻性、单中心研究,研究对象是在 1999 年 1 月至 2002 年 12 月期间接受初级全髋关节置换术(THA)并使用夹层式衬垫(Cerasul)的患者。我们估算了累计发病率,并计算了 95% 置信区间 (95% CI)。采用 Kaplan-Meier 法评估了患者接受修补手术的时间和发生骨折的时间:共纳入了 54 名患者(49 名男性),其中包括 59 名夹层型线性植入者。平均年龄(范围)为 47.4(22-57)岁。THA的主要适应症为骨关节炎(28例)、骨坏死(14例)、儿童病理后遗症(11例)和炎性关节炎(6例)。植入物翻修手术的累计发生率为 8.5%(5/59,95%CI,3.5-19.2%),患者翻修手术的累计发生率为 9.3%(5/54,95%CI,4.0-19.9%),植入物骨折的累计发生率为 5.1%(3/59,95%CI,1.7-13.9%)。中位(四分位距,IQR)翻修手术时间为 158(72.5-161)个月,骨折时间为 182(138-215)个月。所有原发性 THAs 的临床和长期存活率均良好。所有植入物都有牢固固定的迹象:经过20年的随访,聚乙烯-陶瓷夹层型衬垫显示出较长的存活率和较低的植入物骨折累积发生率;然而,植入物骨折仍然是主要的并发症。矫形外科医生应该意识到,一些患者仍在使用这种假体,一旦发生骨折,必须能够迅速做出反应。
{"title":"Long-term follow-up of total hip arthroplasty using polyethylene-ceramic composite (sandwich) liner.","authors":"Daniel Rodríguez-Pérez, Thiago Carnaval, Marcos-Del-Carmen Rodríguez, Antonio Coscujuela-Maña, José-Luis Agulló, Sebastián Videla","doi":"10.1177/11207000241239624","DOIUrl":"10.1177/11207000241239624","url":null,"abstract":"<p><strong>Introduction: </strong>Ceramic-on-ceramic bearings have been widely used since their introduction in the 1970s. First-generation ceramics have very high fracture (breakage) rates. To overcome this, in the 1990s, modular cotyloid insert designs were developed, consisting of a ceramic and polyethylene composite (sandwich-type) liner; however, high implant fracture rates were observed in the medium term. We aimed to estimate the cumulative incidences of revision surgery (implant failure) and implant failure due to fractures, survival rates (time-to-revision surgery and time-to-fracture), and the long-term clinical and radiological outcomes in our series.</p><p><strong>Methods: </strong>This was an observational, longitudinal, ambispective, single-centre study based on patients who underwent primary total hip arthroplasty (THA) using a sandwich-type liner (Cerasul), only available in our tertiary hospital between January 1999 and December 2002. Cumulative incidences were estimated and the 95% confidence interval (95% CI) was calculated. The Kaplan-Meier method was used to assess the time-to-revision surgery and time-to-fracture.</p><p><strong>Results: </strong>54 patients (49 men) were included, accounting for 59 sandwich-type linear implants. The mean (range) age was 47.4 (22-57) years. The primary THA indications were osteoarthritis (28 patients), osteonecrosis (14), childhood pathology sequelae (11), and inflammatory arthritis (6). The cumulative incidence of revision surgery by implants was 8.5% (5/59, 95% CI, 3.5-19.2%), 9.3% by patients (5/54, 95% CI, 4.0-19.9%), and 5.1% by implant fractures (3/59, 95%CI, 1.7-13.9%). The median (Interquartile Range, IQR) time-to-revision surgery was 158 (72.5-161) months, and the time to fracture was 182 (138-215) months. All primary THAs had good clinical and long-term survival outcomes. All implants had signs of solid fixation.</p><p><strong>Conclusions: </strong>After a 20-year follow-up period, the polyethylene-ceramic sandwich-type liner showed a long survival rate and low cumulative incidence of implant fracture; however, implant fractures remain the main complication. Orthopaedic surgeons should be aware that some patients still have this type of prosthesis and must be capable of responding quickly if a fracture occurs.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"467-475"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparison of cemented femoral fixation via anterior versus posterior approach total hip arthroplasty: an analysis of 60,739 total hip arthroplasties. 通过前路与后路全髋关节置换术进行骨水泥股骨固定的比较:对 60739 例全髋关节置换术的分析。
IF 1.3 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-07-01 Epub Date: 2024-03-26 DOI: 10.1177/11207000241239914
Wayne Hoskins, Sophie Corfield, Yi Peng, Stephen E Graves, Roger Bingham

Background: Anterior approach total hip arthroplasty (THA) decreases the rate of dislocation but increases femoral-sided complications in the way of periprosthetic fractures and component loosening. A cemented prosthesis may reduce femoral-sided complications and improve the risk:benefit profile of anterior approach THA.

Methods: Data from the Australian National Joint Replacement Registry were analysed for patients undergoing primary THA via the anterior or posterior approach using a cemented polished femoral stem from January 2015 to December 2021. The primary outcome measure was the cumulative percent revision (CPR) for all causes and CPR for femoral component loosening and fracture. The CPR for the primary outcome measures were compared between the anterior and posterior approach and adjusted for age, sex, ASA score, BMI and femoral head size.

Results: The study included 60,739 THAs with cemented stems (10,742 anterior, 49,997 posterior). The rate of revision of the anterior versus the posterior approach did not significantly differ (HR 0.87 (95% CI, 0.74-1.03), p = 0.100). Anterior approach THA had a significantly higher rate of revision for femoral component loosening (HR 5.06 [95% CI, 3.08-8.30], p < 0.001); and a decreased rate of revision for infection (HR 0.59 [95% CI, 0.43-0.81], p = 0.001) and dislocation/instability (HR 0-3 months 0.48 [95% CI, 0.27-0.83], p = 0.008; HR >3 months 0.30 [95% CI, 0.15-0.61], p < 0.001). There was no difference in the rate of revision surgery for fracture between the 2 approaches (HR 1.01 [95% CI, 0.71-1.43]), p = 0.975).

Conclusions: There is no significant difference in overall revision rates with cemented femoral fixation performed with an anterior or posterior approach. Cemented fixation performed with the anterior approach partly mitigates femoral complications with no difference in the revision rate for fracture but an increased rate of femoral component loosening.

背景:前路全髋关节置换术(THA)可降低脱位率,但会增加股骨侧并发症,如假体周围骨折和组件松动。骨水泥假体可减少股骨侧并发症,改善前路全髋关节置换术的风险收益比:对澳大利亚国家关节置换登记处的数据进行了分析,对象是2015年1月至2021年12月期间通过前路或后路使用骨水泥抛光股骨柄进行初次THA的患者。主要结果指标是所有原因的累计翻修率(CPR)以及股骨组件松动和骨折的CPR。比较了前路和后路方法的主要结局指标CPR,并根据年龄、性别、ASA评分、体重指数和股骨头大小进行了调整:研究包括60739例使用骨水泥柄的THA(前路10742例,后路49997例)。前路与后路的翻修率差异不大(HR 0.87 (95% CI, 0.74-1.03), p = 0.100)。前路THA因股骨组件松动(HR 5.06 [95% CI, 3.08-8.30],P = 0.001)和脱位/不稳定(HR 0-3个月 0.48 [95% CI, 0.27-0.83],P = 0.008;HR >3个月 0.30 [95% CI, 0.15-0.61],P = 0.975)而导致的翻修率明显更高:结论:采用前路或后路进行骨水泥股骨固定术的总体翻修率没有明显差异。采用前路方法进行骨水泥固定可部分缓解股骨并发症,骨折翻修率无差异,但股骨组件松动率增加。
{"title":"A comparison of cemented femoral fixation via anterior versus posterior approach total hip arthroplasty: an analysis of 60,739 total hip arthroplasties.","authors":"Wayne Hoskins, Sophie Corfield, Yi Peng, Stephen E Graves, Roger Bingham","doi":"10.1177/11207000241239914","DOIUrl":"10.1177/11207000241239914","url":null,"abstract":"<p><strong>Background: </strong>Anterior approach total hip arthroplasty (THA) decreases the rate of dislocation but increases femoral-sided complications in the way of periprosthetic fractures and component loosening. A cemented prosthesis may reduce femoral-sided complications and improve the risk:benefit profile of anterior approach THA.</p><p><strong>Methods: </strong>Data from the Australian National Joint Replacement Registry were analysed for patients undergoing primary THA via the anterior or posterior approach using a cemented polished femoral stem from January 2015 to December 2021. The primary outcome measure was the cumulative percent revision (CPR) for all causes and CPR for femoral component loosening and fracture. The CPR for the primary outcome measures were compared between the anterior and posterior approach and adjusted for age, sex, ASA score, BMI and femoral head size.</p><p><strong>Results: </strong>The study included 60,739 THAs with cemented stems (10,742 anterior, 49,997 posterior). The rate of revision of the anterior versus the posterior approach did not significantly differ (HR 0.87 (95% CI, 0.74-1.03), <i>p</i> = 0.100). Anterior approach THA had a significantly higher rate of revision for femoral component loosening (HR 5.06 [95% CI, 3.08-8.30], <i>p</i> < 0.001); and a decreased rate of revision for infection (HR 0.59 [95% CI, 0.43-0.81], <i>p</i> = 0.001) and dislocation/instability (HR 0-3 months 0.48 [95% CI, 0.27-0.83], <i>p</i> = 0.008; HR >3 months 0.30 [95% CI, 0.15-0.61], <i>p</i> < 0.001). There was no difference in the rate of revision surgery for fracture between the 2 approaches (HR 1.01 [95% CI, 0.71-1.43]), <i>p</i> = 0.975).</p><p><strong>Conclusions: </strong>There is no significant difference in overall revision rates with cemented femoral fixation performed with an anterior or posterior approach. Cemented fixation performed with the anterior approach partly mitigates femoral complications with no difference in the revision rate for fracture but an increased rate of femoral component loosening.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"442-451"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MRI spectrum of avascular necrosis of femoral head in patients treated for COVID-19. 接受 COVID-19 治疗的患者股骨头血管性坏死的 MRI 图谱。
IF 1.3 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-07-01 Epub Date: 2024-03-08 DOI: 10.1177/11207000241233906
Khan Akhtar Ali, Lingxiao He, Jianwen Li, Weikai Zhang, Bahebieergan Tasiken, Hui Huang

Background and purpose: This prospective observational study aimed to investigate the occurrence of avascular necrosis (AVN) of the femoral head in COVID-19 patients through MRI scans. The study examined the patterns of AVN in 110 individuals who had undergone conventional COVID-19 therapy and reported hip discomfort. This study highlights the importance of considering AVN as a potential complication of COVID-19 therapy, particularly in younger patients who experience hip discomfort.

Methods: Individuals who had corticosteroid treatment for COVID-19 and experienced hip discomfort during 6 months between January 2022 and August 2022 were included in this study, and an MRI scan was done to observe changes in the hip joint.

Results: The results were classified using the Ficat and Arlet classification system. The analysis revealed that AVN was not present in 91.81% of cases. However, Stage I AVN was detected in 4.54% of cases, Stage II AVN in 2.72% of cases, and Stage III AVN in 1.1% of cases. No cases of Stage IV AVN were observed.

Conclusions: The study concludes that AVN occurred in 6% of individuals who underwent conventional therapy for COVID-19 and experienced hip discomfort. In these settings (post COVID-19), normal MRI results were more typical, and mild AVN (Stage I) was a frequent finding in MRI scans that were positive.

背景和目的:这项前瞻性观察研究旨在通过磁共振成像扫描调查 COVID-19 患者股骨头血管性坏死(AVN)的发生情况。研究对 110 名接受过 COVID-19 常规治疗并报告髋部不适的患者进行了 AVN 模式检查。这项研究强调了将 AVN 视为 COVID-19 疗法潜在并发症的重要性,尤其是对于出现髋部不适的年轻患者:方法:将接受皮质类固醇治疗 COVID-19,并在 2022 年 1 月至 2022 年 8 月的 6 个月期间出现髋部不适的患者纳入本研究,并进行核磁共振成像扫描以观察髋关节的变化:结果:采用 Ficat 和 Arlet 分类系统对结果进行分类。分析结果显示,91.81%的病例不存在 AVN。然而,4.54%的病例发现了Ⅰ期 AVN,2.72%的病例发现了Ⅱ期 AVN,1.1%的病例发现了Ⅲ期 AVN。没有发现 IV 期 AVN:研究得出结论,在接受 COVID-19 传统疗法并出现髋部不适的患者中,有 6% 的人出现了 AVN。在这些情况下(COVID-19 后),正常的 MRI 结果更为典型,而轻度 AVN(I 期)是 MRI 扫描呈阳性的常见结果。
{"title":"MRI spectrum of avascular necrosis of femoral head in patients treated for COVID-19.","authors":"Khan Akhtar Ali, Lingxiao He, Jianwen Li, Weikai Zhang, Bahebieergan Tasiken, Hui Huang","doi":"10.1177/11207000241233906","DOIUrl":"10.1177/11207000241233906","url":null,"abstract":"<p><strong>Background and purpose: </strong>This prospective observational study aimed to investigate the occurrence of avascular necrosis (AVN) of the femoral head in COVID-19 patients through MRI scans. The study examined the patterns of AVN in 110 individuals who had undergone conventional COVID-19 therapy and reported hip discomfort. This study highlights the importance of considering AVN as a potential complication of COVID-19 therapy, particularly in younger patients who experience hip discomfort.</p><p><strong>Methods: </strong>Individuals who had corticosteroid treatment for COVID-19 and experienced hip discomfort during 6 months between January 2022 and August 2022 were included in this study, and an MRI scan was done to observe changes in the hip joint.</p><p><strong>Results: </strong>The results were classified using the Ficat and Arlet classification system. The analysis revealed that AVN was not present in 91.81% of cases. However, Stage I AVN was detected in 4.54% of cases, Stage II AVN in 2.72% of cases, and Stage III AVN in 1.1% of cases. No cases of Stage IV AVN were observed.</p><p><strong>Conclusions: </strong>The study concludes that AVN occurred in 6% of individuals who underwent conventional therapy for COVID-19 and experienced hip discomfort. In these settings (post COVID-19), normal MRI results were more typical, and mild AVN (Stage I) was a frequent finding in MRI scans that were positive.</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"510-515"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140059218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reconstruction of proximal hamstring ruptures restores joint biomechanics during various walking conditions. 腿筋近端断裂的重建可在各种行走条件下恢复关节生物力学。
IF 1.3 4区 医学 Q3 ORTHOPEDICS Pub Date : 2024-07-01 Epub Date: 2024-02-19 DOI: 10.1177/11207000241230282
Marlene Mauch, Corina Nüesch, Linda Bühl, Tomas Chocholac, Annegret Mündermann, Karl Stoffel

Purpose: We aimed to examine the functional outcome in different walking conditions in elderly adults who underwent surgical repair after a non-contact hamstring injury. Our objective was to compare lower limb kinematics and kinetics over the entire gait cycle between the injured and contralateral leg in overground and level and uphill treadmill walking.

Methods: 12 patients (mean ± SD, age: 65 ± 9 years; body mass index: 30 ± 6 kg/m2) walked at self-selected speed in overground (0% slope) and treadmill conditions (0% and 10% slope). We measured spatiotemporal parameters, joint angles (normalised to gait cycle) and joint moments (normalised to stance phase) of the hip, knee and ankle. Data between sides were compared using paired sample t-tests (p< 0.05) and continuous 95% confidence intervals of the paired difference between trajectories.

Results: Patients walked at an average speed of 1.31 ± 0.26 m/second overground and 0.92 ± 0.31 m/second on the treadmill. Spatiotemporal parameters were comparable between the injured and contralateral leg (p> 0.05). Joint kinematic and joint kinetic trajectories were comparable between sides for all walking conditions.

Conclusions: Refixation of the proximal hamstring tendons resulted in comparable ambulatory mechanics at least 1 year after surgery in the injured leg and the contralateral leg, which were all within the range of normative values reported in the literature. These results complement our previous findings on hamstring repair in terms of clinical outcomes and muscle strength and support that surgical repair achieves good functional outcomes in terms of ambulation in an elderly population.

Trial registration: clinicaltrials.gov (NCT04867746).

目的:我们旨在研究非接触式腿筋损伤后接受手术修复的老年人在不同行走条件下的功能结果。方法:12 名患者(平均值 ± SD,年龄:65 ± 9 岁;体重指数:30 ± 6 kg/m2)在地面(0% 坡度)和跑步机(0% 和 10% 坡度)条件下以自选速度行走。我们测量了髋关节、膝关节和踝关节的时空参数、关节角度(按步态周期归一化)和关节力矩(按站立阶段归一化)。采用配对样本 t 检验(p 0.05)和轨迹配对差异的连续 95% 置信区间对两侧数据进行比较:结果:患者在地面行走的平均速度为 1.31 ± 0.26 米/秒,在跑步机上行走的平均速度为 0.92 ± 0.31 米/秒。受伤腿和对侧腿的时空参数相当(P > 0.05)。在所有行走条件下,两侧的关节运动学和关节运动学轨迹均具有可比性:结论:腘绳肌腱近端复位术使受伤腿和对侧腿术后至少 1 年的行走力学具有可比性,均在文献报道的正常值范围内。这些结果补充了我们之前关于腘绳肌腱修复在临床效果和肌肉力量方面的发现,并支持手术修复在老年人群的行走方面取得良好的功能效果。试验注册:clinicaltrials.gov (NCT04867746)。
{"title":"Reconstruction of proximal hamstring ruptures restores joint biomechanics during various walking conditions.","authors":"Marlene Mauch, Corina Nüesch, Linda Bühl, Tomas Chocholac, Annegret Mündermann, Karl Stoffel","doi":"10.1177/11207000241230282","DOIUrl":"10.1177/11207000241230282","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to examine the functional outcome in different walking conditions in elderly adults who underwent surgical repair after a non-contact hamstring injury. Our objective was to compare lower limb kinematics and kinetics over the entire gait cycle between the injured and contralateral leg in overground and level and uphill treadmill walking.</p><p><strong>Methods: </strong>12 patients (mean ± SD, age: 65 ± 9 years; body mass index: 30 ± 6 kg/m<sup>2</sup>) walked at self-selected speed in overground (0% slope) and treadmill conditions (0% and 10% slope). We measured spatiotemporal parameters, joint angles (normalised to gait cycle) and joint moments (normalised to stance phase) of the hip, knee and ankle. Data between sides were compared using paired sample <i>t</i>-tests (<i>p</i> <i><</i> 0.05) and continuous 95% confidence intervals of the paired difference between trajectories.</p><p><strong>Results: </strong>Patients walked at an average speed of 1.31 ± 0.26 m/second overground and 0.92 ± 0.31 m/second on the treadmill. Spatiotemporal parameters were comparable between the injured and contralateral leg (<i>p</i> <i>></i> 0.05). Joint kinematic and joint kinetic trajectories were comparable between sides for all walking conditions.</p><p><strong>Conclusions: </strong>Refixation of the proximal hamstring tendons resulted in comparable ambulatory mechanics at least 1 year after surgery in the injured leg and the contralateral leg, which were all within the range of normative values reported in the literature. These results complement our previous findings on hamstring repair in terms of clinical outcomes and muscle strength and support that surgical repair achieves good functional outcomes in terms of ambulation in an elderly population.</p><p><strong>Trial registration: </strong>clinicaltrials.gov (NCT04867746).</p>","PeriodicalId":12911,"journal":{"name":"HIP International","volume":" ","pages":"516-523"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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HIP International
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