Irvan Dwi Cahyono, Tri Agustina, Sri Wahyu Basuki, Budi Hernawan
The negative impacts of the Covid-19 pandemic include anxiety, stress, reduced appetite, boredom, and physical fitnessproblems. These conditions certainly affect the nutritional status and also the cardiorespiratory fitness of a person. InIndonesia, at least 15 out of 1000 people, or around 2,784,064 individuals suffer from heart disease. In Central JavaProvince, 0.61% of them are children aged 5-14 years old (Riskesdas, 2018). The VO2 Max value is a method formeasuring cardio respiration that can be used to determine which children are at risk of suffering from cardiovasculardisease. The VO2 Max value is influenced by several factors, including nutritional status and exercise habits. Thisstudy aimed to find out the correlation between nutritional status and exercise habits and the value of maximum oxygenvolume (VO2 Max) in male students at SMP Negeri in Temanggung during the Covid-19 pandemic. This was adescriptive-analytic study with across-sectional design. The sampling was done using the purposive sampling methodon 57 samples at SMP Negeri 1 Kaloran. It used Chi-square test for nutritional status variable with p value = 0.000 andexercise habits with p value = 0.001. The logistic regression test was used for each p-value with the nutritional statusOR value of 6.640 and the exercise habit OR value of 4.807 and with R Square value of 0.38 or 38%. There was acorrelation between nutritional status and exercise habits and the value of maximum oxygen volume (VO2 Max) inmale students at SMP Negeri in Temanggung during the Covid-19 pandemic.
{"title":"Hubungan Antara Status Gizi Dan Kebiasaan Berolahraga Dengan Nilai Volume Oksigen Maksimal (VO2 Max) Pada Siswa Laki - Laki SMP Negeri Di Temanggung Selama Pandemi Covid-19","authors":"Irvan Dwi Cahyono, Tri Agustina, Sri Wahyu Basuki, Budi Hernawan","doi":"10.30595/hmj.v4i4.10218","DOIUrl":"https://doi.org/10.30595/hmj.v4i4.10218","url":null,"abstract":"The negative impacts of the Covid-19 pandemic include anxiety, stress, reduced appetite, boredom, and physical fitnessproblems. These conditions certainly affect the nutritional status and also the cardiorespiratory fitness of a person. InIndonesia, at least 15 out of 1000 people, or around 2,784,064 individuals suffer from heart disease. In Central JavaProvince, 0.61% of them are children aged 5-14 years old (Riskesdas, 2018). The VO2 Max value is a method formeasuring cardio respiration that can be used to determine which children are at risk of suffering from cardiovasculardisease. The VO2 Max value is influenced by several factors, including nutritional status and exercise habits. Thisstudy aimed to find out the correlation between nutritional status and exercise habits and the value of maximum oxygenvolume (VO2 Max) in male students at SMP Negeri in Temanggung during the Covid-19 pandemic. This was adescriptive-analytic study with across-sectional design. The sampling was done using the purposive sampling methodon 57 samples at SMP Negeri 1 Kaloran. It used Chi-square test for nutritional status variable with p value = 0.000 andexercise habits with p value = 0.001. The logistic regression test was used for each p-value with the nutritional statusOR value of 6.640 and the exercise habit OR value of 4.807 and with R Square value of 0.38 or 38%. There was acorrelation between nutritional status and exercise habits and the value of maximum oxygen volume (VO2 Max) inmale students at SMP Negeri in Temanggung during the Covid-19 pandemic.","PeriodicalId":12963,"journal":{"name":"Herb-Medicine Journal","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87349373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caisim (Brassica chinensis) is one of the vegetables that has many benefits such as protein, carbohydrates, fat and plays an important role in meeting food needs, and is good for health. Caisim is well adapted to high temperatures and the price is relatively stable and easy to cultivate. The purpose of this study was to determine the presence of Soil-Transmitted Helminths eggs in caisim (B. chinensis). The research was conducted in a descriptive observational. The research was conducted in July-August 2020 at Parasitology and Microbiology Laboratory, Faculty of Medicine, Universitas Muhammadiyah Purwokerto. Identification of Soil-Transmitted Helminths eggs from 20 caisim as the samples used NaCl flotation method and were analyzed by using a univariate test with tabulated frequency distribution. The results showed that no Soil-Transmitted Helminths eggs were found in caisim (B. chinensis). Caisim (Brassica chinensis) merupakan sayuran yang mempunyai banyak kandungan manfaat seperti protein,karbohidrat, lemak dan berperan penting untuk memenuhi kebutuhan pangan serta baik untuk kesehatan. Caisimmampu beradaptasi dengan baik terhadap suhu tinggi serta harga relatif stabil dan mudah diusahakan. Tujuanpenelitian ini untuk mengetahui adanya telur Soil Transmitted Helminths terdapat pada caisim (B. chinensis).Penelitian dilakukan secara observasional deskriptif. Penelitian dilakukan pada bulan Juli-Agustus 2020 diLaboratorium Parasitologi Fakultas Kedokteran Universitas Muhammadiyah Purwokwerto. Identifikasi telur SoilTransmitted Helminthsdari 20 sampel caisim dengan metode Flotasi NaCl. dianalisis dengan uji univariat dengandistribusi tabulasi frekuensi. Hasil penelitian menunjukan tidak ditemukan telur Soil Transmitted Helminths padacaisim (B. chinensis)
caiisim (Brassica chinensis)是一种富含蛋白质、碳水化合物、脂肪等多种益处的蔬菜，在满足食物需求方面起着重要作用，对健康有益。caiisim耐高温，价格相对稳定，易于栽培。本研究的目的是确定中国彩金(B. chinensis)土壤传播蠕虫卵的存在。这项研究是以描述性观察法进行的。该研究于2020年7月至8月在穆罕默迪亚普沃克尔托大学医学院寄生虫学和微生物学实验室进行。采用氯化钠浮选法对20株土传蠕虫卵进行鉴定，采用表列频率分布单因素检验进行分析。结果表明，采金蝇未检出土传虫卵。白菜(芸苔)merupakan sayuran yang mempunyai banyak kandungan manfaat perti protein,karbohidrat, lemak danberperan penting untuk memenuhi kebutuhan pangan serta baik untuk kesehatan。蔡希曼堡是一种具有较强适应能力的城市，也是一种具有较强适应能力的城市。土壤传播蠕虫terdapat pada caisim (B. chinensis)。Penelitian dilakukan secara观测记录。[2]浙江大学学报(自然科学版)。土壤传送带线虫的鉴定。土壤传送带线虫20个样品。单变量登革分布规律分析。土壤传播的中国寄生虫(B. chinensis)
{"title":"Identifikasi Telur Soil Transmitted Helminths Pada Caisim (Brassica chinensis) di Pasar Patikraja Kabupaten Banyumas","authors":"Nurul Qomariyah, Dita Pratiwi Kusuma Wardani, Retno Sulistiyowati","doi":"10.30595/hmj.v4i4.10448","DOIUrl":"https://doi.org/10.30595/hmj.v4i4.10448","url":null,"abstract":"Caisim (Brassica chinensis) is one of the vegetables that has many benefits such as protein, carbohydrates, fat and plays an important role in meeting food needs, and is good for health. Caisim is well adapted to high temperatures and the price is relatively stable and easy to cultivate. The purpose of this study was to determine the presence of Soil-Transmitted Helminths eggs in caisim (B. chinensis). The research was conducted in a descriptive observational. The research was conducted in July-August 2020 at Parasitology and Microbiology Laboratory, Faculty of Medicine, Universitas Muhammadiyah Purwokerto. Identification of Soil-Transmitted Helminths eggs from 20 caisim as the samples used NaCl flotation method and were analyzed by using a univariate test with tabulated frequency distribution. The results showed that no Soil-Transmitted Helminths eggs were found in caisim (B. chinensis). Caisim (Brassica chinensis) merupakan sayuran yang mempunyai banyak kandungan manfaat seperti protein,karbohidrat, lemak dan berperan penting untuk memenuhi kebutuhan pangan serta baik untuk kesehatan. Caisimmampu beradaptasi dengan baik terhadap suhu tinggi serta harga relatif stabil dan mudah diusahakan. Tujuanpenelitian ini untuk mengetahui adanya telur Soil Transmitted Helminths terdapat pada caisim (B. chinensis).Penelitian dilakukan secara observasional deskriptif. Penelitian dilakukan pada bulan Juli-Agustus 2020 diLaboratorium Parasitologi Fakultas Kedokteran Universitas Muhammadiyah Purwokwerto. Identifikasi telur SoilTransmitted Helminthsdari 20 sampel caisim dengan metode Flotasi NaCl. dianalisis dengan uji univariat dengandistribusi tabulasi frekuensi. Hasil penelitian menunjukan tidak ditemukan telur Soil Transmitted Helminths padacaisim (B. chinensis)","PeriodicalId":12963,"journal":{"name":"Herb-Medicine Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86387720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Mustofa, Ninuk Dwi Ariningtyas, Kartika Prahasanti, Muhammad Anas
Preeclampsia is one of the most common complications in pregnancy that can lead to various complications such assevere illness, long-term disability, andmaternal, fetal, and neonatal mortality. The prevalence of preeclampsia, 30%-40% can cause maternal mortality, and 30%-50% can lead to perinatal mortality. Maternal age is one of the riskfactors for late-onset preeclampsia. Maternal age is grouped into two categories; extreme age (<20 years and> 35 years)and reproductive age (21-35 years). This studyaims to determine the relationship between maternal age and late-onsetpreeclampsia at PKU Muhammadiyah Surabaya Hospital from January to June 2020. The research method used isobservational analytic with case control design. The samples involved were pregnant women visiting PKUMuhammadiyah Surabaya Hospital from January to June 2020. The data were analyzed using a statistical test ofcontingency coefficient correlation. The results showed that respondents who experienced late-onset preeclampsia inthe extreme age group (<20 years and> 35 years) were 37 respondents (100%) and in reproductive age (21-35 years)were 28 respondents (80%), the respondent who did not experience late-onset preeclampsia in extreme ages (<20 yearsand> 35 years) was 0 respondents(0%) and in reproductive age (21-35 years) were 7 respondents (20%). The resultsof the statistical test for the contingency coefficient correlation showed a p-value of 0.004 below (≤0.05). All thingsconsidered, there was a significant relationship between maternal age and late-onset preeclampsia at the PKUMuhammadiyah Surabaya Hospital from January to June 2020.
{"title":"Hubungan Antara Usia Ibu Hamil dengan Preeklampsia Tipe Lambat di Rumah Sakit PKU Muhammadiyah Surabaya","authors":"A. Mustofa, Ninuk Dwi Ariningtyas, Kartika Prahasanti, Muhammad Anas","doi":"10.30595/hmj.v4i4.9737","DOIUrl":"https://doi.org/10.30595/hmj.v4i4.9737","url":null,"abstract":"Preeclampsia is one of the most common complications in pregnancy that can lead to various complications such assevere illness, long-term disability, andmaternal, fetal, and neonatal mortality. The prevalence of preeclampsia, 30%-40% can cause maternal mortality, and 30%-50% can lead to perinatal mortality. Maternal age is one of the riskfactors for late-onset preeclampsia. Maternal age is grouped into two categories; extreme age (<20 years and> 35 years)and reproductive age (21-35 years). This studyaims to determine the relationship between maternal age and late-onsetpreeclampsia at PKU Muhammadiyah Surabaya Hospital from January to June 2020. The research method used isobservational analytic with case control design. The samples involved were pregnant women visiting PKUMuhammadiyah Surabaya Hospital from January to June 2020. The data were analyzed using a statistical test ofcontingency coefficient correlation. The results showed that respondents who experienced late-onset preeclampsia inthe extreme age group (<20 years and> 35 years) were 37 respondents (100%) and in reproductive age (21-35 years)were 28 respondents (80%), the respondent who did not experience late-onset preeclampsia in extreme ages (<20 yearsand> 35 years) was 0 respondents(0%) and in reproductive age (21-35 years) were 7 respondents (20%). The resultsof the statistical test for the contingency coefficient correlation showed a p-value of 0.004 below (≤0.05). All thingsconsidered, there was a significant relationship between maternal age and late-onset preeclampsia at the PKUMuhammadiyah Surabaya Hospital from January to June 2020.","PeriodicalId":12963,"journal":{"name":"Herb-Medicine Journal","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74226676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zingiber zerumbet (L) Smith rhizome has been used traditionally as an herbal medicine in Indonesia. Isolated extracts and metabolites of Z. zerumbet have shown anti-inflammatory, antioxidant, antidiabetic, anticancer, antimicrobial, analgesic and antiviral activity. The form of suspension is carried out to facilitate the utilization of the main bioactive content, zerumbone, which is difficult to dissolve in water. The formulation of suspension is based on variations in the concentration of Z. zerumbet extract, which is 2.5% (formulation 1), 5% (formulation 2), and 10% (formulation 3). To determine the physical stability, the evaluation is carried out, namely: organoleptic test, density, viscosity, redispersibility and pH. The results showed all three formulations did not provide organoleptic changes for 30 days, >1 g/cm3 density, good redispersibility, and pH of 6. The viscosity of each formulation is quite varied i.e., 3.74 cp; 4,27 cp; and 11.8 cp. Formulation 3 is determined as the best formulation based on its viscosity which is closest to the standard range of good suspension viscosity according to the SNI.
{"title":"Formulasi dan Uji Stabilitas Sediaan Suspensi Ekstrak Rimpang Zingiber zerumbet","authors":"Shafa Shavira, Angel Dineta Margaretta, Aprilia Dwi Sandra, Raya Uli Sitorus, Fatmaria Fatmaria","doi":"10.30595/hmj.v4i4.11628","DOIUrl":"https://doi.org/10.30595/hmj.v4i4.11628","url":null,"abstract":"Zingiber zerumbet (L) Smith rhizome has been used traditionally as an herbal medicine in Indonesia. Isolated extracts and metabolites of Z. zerumbet have shown anti-inflammatory, antioxidant, antidiabetic, anticancer, antimicrobial, analgesic and antiviral activity. The form of suspension is carried out to facilitate the utilization of the main bioactive content, zerumbone, which is difficult to dissolve in water. The formulation of suspension is based on variations in the concentration of Z. zerumbet extract, which is 2.5% (formulation 1), 5% (formulation 2), and 10% (formulation 3). To determine the physical stability, the evaluation is carried out, namely: organoleptic test, density, viscosity, redispersibility and pH. The results showed all three formulations did not provide organoleptic changes for 30 days, >1 g/cm3 density, good redispersibility, and pH of 6. The viscosity of each formulation is quite varied i.e., 3.74 cp; 4,27 cp; and 11.8 cp. Formulation 3 is determined as the best formulation based on its viscosity which is closest to the standard range of good suspension viscosity according to the SNI.","PeriodicalId":12963,"journal":{"name":"Herb-Medicine Journal","volume":"122 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73454640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bella Chrysthya Utamy, N. Yuliani, Dewi Klarita Furtuna
Infectious diseases are one of the most frequent diseases of major health problems, caused by bacteria are still beinga health problem in developing countries as well as in developed countries. One of the mostly occurred respiratorytract infection is pneumonia, this caused by Gram-positive bacteria Streptococcus pneumoniae. Gastrointestinaldiseases that are often caused by gram-negative bacterial infections Escherichia coli. Local plant which can be foundin Central Kalimantan are Suna onion (Allium schoenoprasum L.). Suna onion (Allium schoenoprasum L.).Researchpurposes. Research was conducted to determine the influence of the Suna’s bulb (Allium schoenoprasum L.) filtratedby aquadest with a simple filtration technique on the growth of Streptococcus pneumoniae and Escherichia usingKirby-Bauer Disk Diffusion method. Method. This type of research is true experimental design research. The designused in this study was post test-only control group design. This research uses 7 treatment groups, with concentrationsof 100%, 75%, 50%, 25%, 12.5%. Aquadest as a negative control, Erytromycin and Cifrofloxacin as positivecontrols. The method used for testing the antibacterial activity are Kirby-BaueDisk Diffusionmethod.The resultsfound that the aquadest tuber extract of onion cannot inhibit the growth of Streptococcus pneumoniae andEscherichia coli. Conclusion. Aquadest filtrate of onion tubers (Allium schoenprasum L.) cannot inhibit the growthof Streptococcus pneumoniae and Escherichia coli
{"title":"Perbandingan Uji Aktivitas Antibakteri Filtrat Aquadest Umbi Bawang Suna (Allium schoenoprasum L.) Terhadap Pertumbuhan Streptococcus pneumoniae Dan Escherichia coli Dengan Metode Difusi Cakram Kirby-Bauer","authors":"Bella Chrysthya Utamy, N. Yuliani, Dewi Klarita Furtuna","doi":"10.30595/hmj.v4i4.8812","DOIUrl":"https://doi.org/10.30595/hmj.v4i4.8812","url":null,"abstract":"Infectious diseases are one of the most frequent diseases of major health problems, caused by bacteria are still beinga health problem in developing countries as well as in developed countries. One of the mostly occurred respiratorytract infection is pneumonia, this caused by Gram-positive bacteria Streptococcus pneumoniae. Gastrointestinaldiseases that are often caused by gram-negative bacterial infections Escherichia coli. Local plant which can be foundin Central Kalimantan are Suna onion (Allium schoenoprasum L.). Suna onion (Allium schoenoprasum L.).Researchpurposes. Research was conducted to determine the influence of the Suna’s bulb (Allium schoenoprasum L.) filtratedby aquadest with a simple filtration technique on the growth of Streptococcus pneumoniae and Escherichia usingKirby-Bauer Disk Diffusion method. Method. This type of research is true experimental design research. The designused in this study was post test-only control group design. This research uses 7 treatment groups, with concentrationsof 100%, 75%, 50%, 25%, 12.5%. Aquadest as a negative control, Erytromycin and Cifrofloxacin as positivecontrols. The method used for testing the antibacterial activity are Kirby-BaueDisk Diffusionmethod.The resultsfound that the aquadest tuber extract of onion cannot inhibit the growth of Streptococcus pneumoniae andEscherichia coli. Conclusion. Aquadest filtrate of onion tubers (Allium schoenprasum L.) cannot inhibit the growthof Streptococcus pneumoniae and Escherichia coli","PeriodicalId":12963,"journal":{"name":"Herb-Medicine Journal","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80795380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farah Akhwanis Syifa, Rizka Adi Nugraha Putra, Andi Muhammad Maulana, Susiyadi Susiyadi
According to the European Food Safety Authority (EFSA),the allowed level of Monosodium glutamate (MSG)consumption is 30 mg / kgbw per day. Several studies show that long-term MSG is toxic to the kidneys bycausingoxidative stress and decreasing thekidney function.This study was based on the potential for impaired kidneyfunction and structure caused by excessive consumption of MSG and basil leaves (Ocimum basilicum L.) asantioxidant plants with flavonoid content. To find out the effect of basil (Ocimum basilicum L.) leaves’ ethanolextract dose 175 mg / kgbw, 350 mg / kgbw and 700 mg / kgbw against kidney tubular injury on white rats WistarStrain induced by MSG.This study was a quasi-experimental study with a randomized post-test only controlledgroup design. The number of samples was 25 ABM, divided into five groups, the positive control group (K+), thenegative control group (K-) and the treatment group (K1,K2 and K3).In the group given basil leaves ethanol extractdoses of 175, 350 and 700 mg / kgbw, there was a decrease in tubular injury in the kidney of the white rat (Rattusnorvegicus) Wistar strain induced by MSG 1.6 g/day orally. The optimal dose in this study was 700 mg / kgbw. Teststatistics indicated significant differences in all five groups (p < 0.05).The administration of ethanol extract of basilleaves (Ocimum basilicumL.) was able to prevent tubular injury in the kidney of the white rat (Rattus norvegicus)Wistar strain induced by MSG. Kadar konsumsi MSG yang diperbolehkan menurut Europian Food Safety Authority (EFSA) yaitu 30 mg/kgBB per hari. Beberapa studi pada hewan coba menunjukkan bahwa pemberian MSG jangka panjang bersifat toksik padaginjal dengan menyebabkan stress oksidatif dan menurunkan fungsi ginjal. Penggunaan tanaman yang mengandungantioksidan dapat meningkatkan mekanisme dalam tubuh untuk mencegah stres oksidatif. Penelitian ini didasarkanoleh potensi terjadinya gangguan fungsi dan struktur ginjal akibat stres oksidatif yang disebabkan oleh konsumsiMSG berlebih serta daun kemangi (Ocimum basilicum L.) sebagai tanaman antioksidan dengan kandunganflavonoid.Mengetahui pengaruh pemberian ekstrak etanol daun kemangi (Ocimum basilicum L.) dosis 175,350 dan700 mg/kgBB terhadap cedera tubulus pada BBT ginjal tikus putih (Rattus norvegicus) galur Wistar yang diinduksiMSG.Penelitian ini merupakan jenis penelitian quasi-experimental dengan rancangan randomized post test onlycontrolled group. Jumlah sampel sebanyak 25 BBT, terbagi menjadi lima kelompok, yaitu kontrol positif (K+),kontrol negatif (K-) dan kelompok perlakuan ekstrak daun kemangi (K1, K2 dan K3).Pada kelompok pemberianekstrak etanol daun kemangi terjadi penurunan cedera tubulus pada ginjal tikus putih (Rattus norvegicus) galur Wistar yang diinduksi MSG 1,6 g/hari secara oral. Dosis optimal ekstrak etanol daun kemangi padapenelitian iniyaitu 700 mg/kgBB. Uji statistik menuunjukkan perbedaan yang signifikan pada kelima kelompok (p<0,05). Pemberian ekstrak etanol daun kema
根据欧洲食品安全局(EFSA)的规定，味精(MSG)的允许摄入量为每天30毫克/千克。一些研究表明，长期服用味精会引起氧化应激，降低肾功能，从而对肾脏有害。这项研究是基于过量食用味精和罗勒叶(Ocimum basilicum L.)作为类黄酮含量的抗氧化植物而引起的肾脏功能和结构受损的可能性。探讨175 mg / kgbw、350 mg / kgbw和700 mg / kgbw罗勒叶乙醇提取物对味精致大鼠肾小管损伤的影响。本研究为准实验研究，采用随机后验组设计。样本数量为25个ABM，分为阳性对照组(K+)、阴性对照组(K-)和治疗组(K1、K2、K3) 5组。罗勒叶乙醇提取物175、350和700 mg / kgbw组，味精1.6 g/d对大鼠Wistar肾小管损伤的影响均有所减轻。本研究的最佳剂量为700 mg / kgbw。经检验，五组间差异均有统计学意义(p < 0.05)。罗勒叶(Ocimum basilicumL.)乙醇提取物可预防味精诱导的褐家鼠Wistar肾小管损伤。欧洲食品安全局(EFSA)批准30mg /kgBB / hari。Beberapa研究了pada hewan coba menunjukkan bahwa pemberian MSG jangka panjang bersifat toksik padaginjal dengan menyebabkan应力对menurunkan真菌ginal的影响。Penggunaan tanaman yang mengandunantioksidan dapat meningkatkan mekanisme dalam tubuh untuk menegah应力oksidatif。struktur Penelitian ini didasarkanoleh potensi terjadinya gangguan fungsi丹ginjal akibat度假oksidatif杨disebabkan oleh pokalchuk konsumsiMSG berlebih舒达daun kemangi(罗勒属basilicum l .) sebagai tanaman antioksidan dengan kandunganflavonoid。孟格塔辉彭加鲁彭加鲁麝香麝香醚(Ocimum basilicum L.)剂量为175,350 dan700 mg/kgBB;樟脑管(cedera tubulus);褐家鼠(Rattus norvegicus);Penelitian ini merupakan jenis Penelitian准实验，仅对照组随机后验。Jumlah样品sebanyak 25bbt, terbagi menjadi lima kelompok, yitu对照阳性(K+)，对照阴性(K-)但kelompok perlakuan ekstrak daum kemangi (K1, K2和K3)。Pada kelompok pemberianekstrak乙醇、kemangi terjadi penuruni penuruni、Pada ginjal tius putih(褐家鼠)galur Wistar yang diinduksi MSG 1,6 g/hari secara口服。最佳剂量为700 mg/kgBB。Uji统计学上menuunjukkan perbedaan和yang统计学上有显著性差异(p< 0.05)。Pemberian ekstrak etanoi (basilicum L.) dapat menegah terjadinya cedera tubulus padaginjal tikus putih (Rattus norvegicus) galur Wistar yang diinduksi MSG。
{"title":"Pengaruh Pemberian Ekstrak Etanol Daun Kemangi (Ocimum basilicum L.) Terhadap Cedera Tubulus Ginjal","authors":"Farah Akhwanis Syifa, Rizka Adi Nugraha Putra, Andi Muhammad Maulana, Susiyadi Susiyadi","doi":"10.30595/hmj.v4i4.4555","DOIUrl":"https://doi.org/10.30595/hmj.v4i4.4555","url":null,"abstract":"According to the European Food Safety Authority (EFSA),the allowed level of Monosodium glutamate (MSG)consumption is 30 mg / kgbw per day. Several studies show that long-term MSG is toxic to the kidneys bycausingoxidative stress and decreasing thekidney function.This study was based on the potential for impaired kidneyfunction and structure caused by excessive consumption of MSG and basil leaves (Ocimum basilicum L.) asantioxidant plants with flavonoid content. To find out the effect of basil (Ocimum basilicum L.) leaves’ ethanolextract dose 175 mg / kgbw, 350 mg / kgbw and 700 mg / kgbw against kidney tubular injury on white rats WistarStrain induced by MSG.This study was a quasi-experimental study with a randomized post-test only controlledgroup design. The number of samples was 25 ABM, divided into five groups, the positive control group (K+), thenegative control group (K-) and the treatment group (K1,K2 and K3).In the group given basil leaves ethanol extractdoses of 175, 350 and 700 mg / kgbw, there was a decrease in tubular injury in the kidney of the white rat (Rattusnorvegicus) Wistar strain induced by MSG 1.6 g/day orally. The optimal dose in this study was 700 mg / kgbw. Teststatistics indicated significant differences in all five groups (p < 0.05).The administration of ethanol extract of basilleaves (Ocimum basilicumL.) was able to prevent tubular injury in the kidney of the white rat (Rattus norvegicus)Wistar strain induced by MSG. Kadar konsumsi MSG yang diperbolehkan menurut Europian Food Safety Authority (EFSA) yaitu 30 mg/kgBB per hari. Beberapa studi pada hewan coba menunjukkan bahwa pemberian MSG jangka panjang bersifat toksik padaginjal dengan menyebabkan stress oksidatif dan menurunkan fungsi ginjal. Penggunaan tanaman yang mengandungantioksidan dapat meningkatkan mekanisme dalam tubuh untuk mencegah stres oksidatif. Penelitian ini didasarkanoleh potensi terjadinya gangguan fungsi dan struktur ginjal akibat stres oksidatif yang disebabkan oleh konsumsiMSG berlebih serta daun kemangi (Ocimum basilicum L.) sebagai tanaman antioksidan dengan kandunganflavonoid.Mengetahui pengaruh pemberian ekstrak etanol daun kemangi (Ocimum basilicum L.) dosis 175,350 dan700 mg/kgBB terhadap cedera tubulus pada BBT ginjal tikus putih (Rattus norvegicus) galur Wistar yang diinduksiMSG.Penelitian ini merupakan jenis penelitian quasi-experimental dengan rancangan randomized post test onlycontrolled group. Jumlah sampel sebanyak 25 BBT, terbagi menjadi lima kelompok, yaitu kontrol positif (K+),kontrol negatif (K-) dan kelompok perlakuan ekstrak daun kemangi (K1, K2 dan K3).Pada kelompok pemberianekstrak etanol daun kemangi terjadi penurunan cedera tubulus pada ginjal tikus putih (Rattus norvegicus) galur Wistar yang diinduksi MSG 1,6 g/hari secara oral. Dosis optimal ekstrak etanol daun kemangi padapenelitian iniyaitu 700 mg/kgBB. Uji statistik menuunjukkan perbedaan yang signifikan pada kelima kelompok (p<0,05). Pemberian ekstrak etanol daun kema","PeriodicalId":12963,"journal":{"name":"Herb-Medicine Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91062022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Virena Audelia Rambang, F. Ria, Natalia Sri Martani
ABSTRACT Stroke is still the main cause of morbidity and mortality in the world. Research found "aspirin resistant" in 5-60% of cases, it’s necessary to develop researches related to antiplatelet therapy. In the antiplatelet research on plant extracts, some were significant and some weren’t. To determine active compound of plant extracts, fractions, mechanism of action, extraction method, isolation methods of active compounds with antiplatelet activity. Literature studies with a systematic approach, data from original articles in GoogleScholar, PubMed. Obtained 32 literatures through data quality analysis and topic suitability. Data synthesis using PICO method. 30 journals significantly have antiplatelet activity, 2 weren’t, the most found compounds were flavonoids, quercetin. Mechanism of action as an antiplatelet, antithrombotic. Extraction methods maceration, reflux, juice, sonication, soxhlet, distillation. The isolation methods using CC, HPLC, TLC, NMR. Conclusion: Insignificant results are from AGE and raw, boiled, fried garlic, both tested in vivo. Journals that significantly have antiplatelet results are from extracts of strawberries, grape seeds, Allium sp., Bay leaves, mango peel, tomatoes, Hawthorn, C.aromatica Salisb., Red ginger, G.verrucosa, S.polycystum, olive leaves, M.alba, P.baumii, R.vernicflua, A.shikokiana, katuk leaves, tempuyung leaves, red cabbage, M.obovata, lempeni leaves, kajajahi leaves, starfruit leaves, U.macrocarpa, M.citrifolia, C.limon, L.japonica, E.bicyclis, S.deserta, V.labrusca. Most found active compound with antiplatelet activity are flavonoids, fraction quercetin. Mechanism of action on COX-1, AA, TXA2, P13K pathways, increased cAMP, VASP stimulation. Extraction methods by maceration, reflux, soxhlet, sonication, juice, distillation. Isolation methods using CC, HPLC, TLC, NMR
{"title":"Literature Review: Analisis Senyawa Aktif Ekstrak Dan Fraksi Tanaman Berpotensi Sebagai Antiplatelet","authors":"Virena Audelia Rambang, F. Ria, Natalia Sri Martani","doi":"10.30595/hmj.v4i3.9436","DOIUrl":"https://doi.org/10.30595/hmj.v4i3.9436","url":null,"abstract":"ABSTRACT Stroke is still the main cause of morbidity and mortality in the world. Research found \"aspirin resistant\" in 5-60% of cases, it’s necessary to develop researches related to antiplatelet therapy. In the antiplatelet research on plant extracts, some were significant and some weren’t. To determine active compound of plant extracts, fractions, mechanism of action, extraction method, isolation methods of active compounds with antiplatelet activity. Literature studies with a systematic approach, data from original articles in GoogleScholar, PubMed. Obtained 32 literatures through data quality analysis and topic suitability. Data synthesis using PICO method. 30 journals significantly have antiplatelet activity, 2 weren’t, the most found compounds were flavonoids, quercetin. Mechanism of action as an antiplatelet, antithrombotic. Extraction methods maceration, reflux, juice, sonication, soxhlet, distillation. The isolation methods using CC, HPLC, TLC, NMR. Conclusion: Insignificant results are from AGE and raw, boiled, fried garlic, both tested in vivo. Journals that significantly have antiplatelet results are from extracts of strawberries, grape seeds, Allium sp., Bay leaves, mango peel, tomatoes, Hawthorn, C.aromatica Salisb., Red ginger, G.verrucosa, S.polycystum, olive leaves, M.alba, P.baumii, R.vernicflua, A.shikokiana, katuk leaves, tempuyung leaves, red cabbage, M.obovata, lempeni leaves, kajajahi leaves, starfruit leaves, U.macrocarpa, M.citrifolia, C.limon, L.japonica, E.bicyclis, S.deserta, V.labrusca. Most found active compound with antiplatelet activity are flavonoids, fraction quercetin. Mechanism of action on COX-1, AA, TXA2, P13K pathways, increased cAMP, VASP stimulation. Extraction methods by maceration, reflux, soxhlet, sonication, juice, distillation. Isolation methods using CC, HPLC, TLC, NMR","PeriodicalId":12963,"journal":{"name":"Herb-Medicine Journal","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84894946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manajemen nyeri sangat penting bagi pasien bedah untuk mencegah efek samping nyeri post operasi dan memfasilitasi pemulihan. Manajemen nyeri non farmakologi mengurangi efek emosional dari nyeri, meningkatkan penyesuaian dan membuat pasien percaya dapat mengendalikan rasa nyerinya, sehingga mengurangi nyeri dan meningkatkan tidur. Melakukan literature review terhadap artikel-artikel yang meneliti tentang menejemen nyeri non farmakologi pada pasien post operasi dengan terapi spiritual “doa dan dzikir”. Menggunakan database dengan penelusuran elektronik pada Google, Google Scholar dan PubMed yang dipublikasikan pada tahun 2013-2018. Lima artikel dipakai dalam review. Tiga artikel menyebutkan manajemen nyeri non farmakologi dengan membaca doa dan dzikir: melafalkan bacaan Tasbih 33 kali, Tahmid 33 kali, Takbir 33 kali, Tahlil 33 kali, Alhauqalah 33 kali selama 10-15 menit atau 30 menit. Diawali dengan melakukan tehnik napas dalam selama 5 menit atau membaca dzikir Hazrate Zahra (menyebut nama “Allah”) 100 kali. Dilanjutkan membaca surat Al-fatihah dan diakhiri doa menghilangkan rasa sakit 7 kali. Dipraktikkan dengan posisi duduk/berbaring dengan nyaman, dengan mata tertutup. Dua artikel lain dengan mendengarkan doa "Ya man esmoho davaa va zekroho shafa, Allahomma salle ala mohammad va ale mohammad" selama 20 menit pada post operasi atau pembacaan doa salawat syifa ' dan dzikir pada intraoperasi. Doa dan dzikir adalah teknik non farmakologi berbiaya rendah, mudah, nyaman dilakukan kapanpun dan dimanapun, tidak memiliki efek samping. Membaca doa dan dzikir maupun mendengarkannya terbukti menurunkan intensitas nyeri post operasi
{"title":"Manajemen Nyeri Non Farmakologi Post Operasi Dengan Terapi Spiritual “Doa dan Dzikir”: A Literature Review","authors":"Tina Muzaenah, Ariska Hidayati","doi":"10.30595/hmj.v4i3.8022","DOIUrl":"https://doi.org/10.30595/hmj.v4i3.8022","url":null,"abstract":"Manajemen nyeri sangat penting bagi pasien bedah untuk mencegah efek samping nyeri post operasi dan memfasilitasi pemulihan. Manajemen nyeri non farmakologi mengurangi efek emosional dari nyeri, meningkatkan penyesuaian dan membuat pasien percaya dapat mengendalikan rasa nyerinya, sehingga mengurangi nyeri dan meningkatkan tidur. Melakukan literature review terhadap artikel-artikel yang meneliti tentang menejemen nyeri non farmakologi pada pasien post operasi dengan terapi spiritual “doa dan dzikir”. Menggunakan database dengan penelusuran elektronik pada Google, Google Scholar dan PubMed yang dipublikasikan pada tahun 2013-2018. Lima artikel dipakai dalam review. Tiga artikel menyebutkan manajemen nyeri non farmakologi dengan membaca doa dan dzikir: melafalkan bacaan Tasbih 33 kali, Tahmid 33 kali, Takbir 33 kali, Tahlil 33 kali, Alhauqalah 33 kali selama 10-15 menit atau 30 menit. Diawali dengan melakukan tehnik napas dalam selama 5 menit atau membaca dzikir Hazrate Zahra (menyebut nama “Allah”) 100 kali. Dilanjutkan membaca surat Al-fatihah dan diakhiri doa menghilangkan rasa sakit 7 kali. Dipraktikkan dengan posisi duduk/berbaring dengan nyaman, dengan mata tertutup. Dua artikel lain dengan mendengarkan doa \"Ya man esmoho davaa va zekroho shafa, Allahomma salle ala mohammad va ale mohammad\" selama 20 menit pada post operasi atau pembacaan doa salawat syifa ' dan dzikir pada intraoperasi. Doa dan dzikir adalah teknik non farmakologi berbiaya rendah, mudah, nyaman dilakukan kapanpun dan dimanapun, tidak memiliki efek samping. Membaca doa dan dzikir maupun mendengarkannya terbukti menurunkan intensitas nyeri post operasi ","PeriodicalId":12963,"journal":{"name":"Herb-Medicine Journal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80642966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Type-2 diabetes is a metabolic disease characterized by an increase in blood sugar levels due to decreased insulin secretion by pancreatic beta cells, or inappropriate insulin action. The pathophysiology of type-2 diabetes is related to inflammatory mechanisms caused by an increase in proinflammatory cytokines such as IL-6. Propolis has an anti-inflammatory role that can influence type 2 diabetes. To determine the effect of propolis as an anti-inflammatory to the IL-6 cytokines in type 2 Diabetes Mellitus A Literature review by searching electronic databases on Pubmed, ProQuest, and Google Scholar with the keywords "propolis or bee propolis and IL-6 levels or interleukin-6 levels and diabetes type-2 or type-2 diabetes" published in 2010-2020. Based on the search results, 9 journals were found. These articles consist of 5 experimental articles and 4 RCT articles. Five databases reported a decrease in IL-6 levels and three journals stated that there was an increase in IL-6 levels in the type-2 diabetes group after being given propolis. One journal reported no significant difference. Variations in propolis administration and time in IL-6 measurements affected the tendency to decrease IL-6 levels in type 2 diabetes patients. The active components in propolis were influenced by differences in plant resources, collection season, bee species, and solvents used in the extraction. IL-6 levels in the type-2 diabetes group tended to decrease after propolis administration compared to the type-2 diabetes group without propolis administration. IL-6 levels in the type-2 diabetes group increased after propolis administration because IL-6 helps improve chronic inflammation associated with type-2 diabetes.
{"title":"Pengaruh Propolis Terhadap Il-6 Pada Diabetes Melitus Tipe 2: A Literature Review","authors":"Nazula Rahma Shafriani","doi":"10.30595/hmj.v4i3.9476","DOIUrl":"https://doi.org/10.30595/hmj.v4i3.9476","url":null,"abstract":"Type-2 diabetes is a metabolic disease characterized by an increase in blood sugar levels due to decreased insulin secretion by pancreatic beta cells, or inappropriate insulin action. The pathophysiology of type-2 diabetes is related to inflammatory mechanisms caused by an increase in proinflammatory cytokines such as IL-6. Propolis has an anti-inflammatory role that can influence type 2 diabetes. To determine the effect of propolis as an anti-inflammatory to the IL-6 cytokines in type 2 Diabetes Mellitus A Literature review by searching electronic databases on Pubmed, ProQuest, and Google Scholar with the keywords \"propolis or bee propolis and IL-6 levels or interleukin-6 levels and diabetes type-2 or type-2 diabetes\" published in 2010-2020. Based on the search results, 9 journals were found. These articles consist of 5 experimental articles and 4 RCT articles. Five databases reported a decrease in IL-6 levels and three journals stated that there was an increase in IL-6 levels in the type-2 diabetes group after being given propolis. One journal reported no significant difference. Variations in propolis administration and time in IL-6 measurements affected the tendency to decrease IL-6 levels in type 2 diabetes patients. The active components in propolis were influenced by differences in plant resources, collection season, bee species, and solvents used in the extraction. IL-6 levels in the type-2 diabetes group tended to decrease after propolis administration compared to the type-2 diabetes group without propolis administration. IL-6 levels in the type-2 diabetes group increased after propolis administration because IL-6 helps improve chronic inflammation associated with type-2 diabetes.","PeriodicalId":12963,"journal":{"name":"Herb-Medicine Journal","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77294408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Longer immunity to Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2) infection is thought to occur through memory cellular responses by activity of specific T lymphocytes. However, most patients with Coronavirus disease-19 (Covid-19) experienced a decrease in the number of T lymphocytes or lymphopenia. Agents that help maintain T cell counts such as Curcumin appear to have played an important role during the Covid-19 pandemic. Curcumin is known to provide a balance between T cell effectiveness and T cell autoaggressiveness, as well as restoring memory T cell function as observed in tumor-induced mice. The mixture of 4 herbal extracts of empon-empon which is commonly used as herbal medicine, namely temulawak, ginger, lemongrass, and turmeric, is thought to have the same effect as curcumin. This is known from the tracing of a plant-protein-compound database which shows that there are not many compounds other than curcumin that can modulate T cells. It is necessary to study the role of Curcumin and a mixture of 4 herbal empon-empon in modulating T cells in cases of infection by the SARS-Cov-2 antigen.
{"title":"Potensi Curcumin dan 4 Herbal Empon-Empon Dalam Memodulasi Kekebalan Sel T Terhadap Covid-19","authors":"Aryo Tedjo, D. Noor, R. Heryanto","doi":"10.30595/hmj.v4i3.10209","DOIUrl":"https://doi.org/10.30595/hmj.v4i3.10209","url":null,"abstract":"Longer immunity to Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2) infection is thought to occur through memory cellular responses by activity of specific T lymphocytes. However, most patients with Coronavirus disease-19 (Covid-19) experienced a decrease in the number of T lymphocytes or lymphopenia. Agents that help maintain T cell counts such as Curcumin appear to have played an important role during the Covid-19 pandemic. Curcumin is known to provide a balance between T cell effectiveness and T cell autoaggressiveness, as well as restoring memory T cell function as observed in tumor-induced mice. The mixture of 4 herbal extracts of empon-empon which is commonly used as herbal medicine, namely temulawak, ginger, lemongrass, and turmeric, is thought to have the same effect as curcumin. This is known from the tracing of a plant-protein-compound database which shows that there are not many compounds other than curcumin that can modulate T cells. It is necessary to study the role of Curcumin and a mixture of 4 herbal empon-empon in modulating T cells in cases of infection by the SARS-Cov-2 antigen.","PeriodicalId":12963,"journal":{"name":"Herb-Medicine Journal","volume":"235 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73511535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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