首页 > 最新文献

High altitude medicine & biology最新文献

英文 中文
Re: "Shortening Work-Rest Durations Reduces Physiological and Perceptual Load During Uphill Walking in Simulated Cold High-Altitude Conditions" by Fornasiero et al. 关于Fornasiero 等人撰写的 "在模拟寒冷的高海拔条件下缩短工作-休息时间可减轻上坡行走时的生理和知觉负荷 "一文
IF 1.6 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-12-01 Epub Date: 2020-12-22 DOI: 10.1089/ham.2020.0181
Dermas Chaen, Igor Trapellieni
{"title":"Re: \"Shortening Work-Rest Durations Reduces Physiological and Perceptual Load During Uphill Walking in Simulated Cold High-Altitude Conditions\" by Fornasiero et al.","authors":"Dermas Chaen, Igor Trapellieni","doi":"10.1089/ham.2020.0181","DOIUrl":"10.1089/ham.2020.0181","url":null,"abstract":"","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25404334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frostbite and Mortality in Mountaineering Women: A Scoping Review-UIAA Medical Commission Recommendations. 登山妇女的冻伤和死亡率:UIAA医学委员会建议的范围审查。
IF 1.6 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-12-01 Epub Date: 2023-10-12 DOI: 10.1089/ham.2023.0040
Susi Kriemler, Kastė Mateikaitė-Pipirienė, Alison Rosier, Linda E Keyes, Peter Paal, Marija Andjelkovic, Beth A Beidleman, Mia Derstine, Jacqueline Pichler Hefti, David Hillebrandt, Lenka Horakova, Dominique Jean

Kriemler, Susi, Kastė Mateikaitė-Pipirienė, Alison Rosier, Linda E. Keyes, Peter Paal, Marija Andjelkovic, Beth A. Beidleman, Mia Derstine, Jacqueline Pichler Hefti, David Hillebrandt, Lenka Horakova, and Dominique Jean; for the UIAA MedCom Writing Group on Women's Health in the Mountains. Frostbite and mortality in mountaineering women: a scoping review-UIAA Medical Commission recommendations. High Alt Med Biol. 24:247-258, 2023. Background: The harsh environment of high altitudes (HA) poses many serious health risks for mountaineers, including cold injuries and death. The aim of this work was to review whether female mountaineers are at special risk for frostbite or death at HA compared with their male counterparts. Methods: The UIAA Medical Commission convened an international author team to review women's health issues at HA and to publish updated recommendations. Pertinent literature from PubMed and Cochrane was identified with additional publications found by hand search. The primary search focus was for articles assessing cold injuries and death in women mountaineers at HA. Results: We reviewed the literature and identified 20 relevant studies: 2 studies on frostbite at HA, plus 7 studies and 1 report for death at HA. An additional 10 studies about frostbite at low altitude were included. We found that female mountaineers at HA were at lower risk of death than their male counterparts, but sex differences in frostbite were inconclusive. Conclusions: The frequency of cold injuries and mortality in female mountaineers is not yet well studied, and the studies that have been published tend to lack precise exposure data. More studies and registries with sex-differentiated data are needed.

Kriemler、Susi、KastëMateikaitë-Pipirienë、Alison Rosier、Linda E.Keyes、Peter Paal、Marija Andjelkovic、Beth A.Beidleman、Mia Derstine、Jacqueline Pichler Hefti、David Hillebrandt、Lenka Horakova和Dominique Jean;UIAA MedCom山区妇女健康写作小组。登山妇女的冻伤和死亡率:UIAA医学委员会建议的范围审查。High Alt-Med Biol 00:000-0002023。背景:高海拔地区恶劣的环境给登山者带来了许多严重的健康风险,包括冷伤和死亡。这项工作的目的是审查女性登山者与男性登山者相比,在HA是否有冻伤或死亡的特殊风险。方法:UIAA医学委员会召集了一个国际作者小组,审查医管局的妇女健康问题,并发布最新建议。PubMed和Cochrane的相关文献通过手工搜索发现了其他出版物。主要搜寻对象是医管局评估女性登山运动员冷伤及死亡的文章。结果:我们回顾了文献,确定了20项相关研究:2项关于HA冻伤的研究,加上7项关于HA死亡的研究和1份报告。另外还包括10项关于低海拔地区冻伤的研究。我们发现,HA的女性登山者的死亡风险比男性登山者低,但冻伤的性别差异尚不确定。结论:女性登山运动员冷伤和死亡的频率尚未得到很好的研究,已经发表的研究往往缺乏准确的暴露数据。需要更多的具有性别差异数据的研究和登记。
{"title":"Frostbite and Mortality in Mountaineering Women: A Scoping Review-UIAA Medical Commission Recommendations.","authors":"Susi Kriemler, Kastė Mateikaitė-Pipirienė, Alison Rosier, Linda E Keyes, Peter Paal, Marija Andjelkovic, Beth A Beidleman, Mia Derstine, Jacqueline Pichler Hefti, David Hillebrandt, Lenka Horakova, Dominique Jean","doi":"10.1089/ham.2023.0040","DOIUrl":"10.1089/ham.2023.0040","url":null,"abstract":"<p><p>Kriemler, Susi, Kastė Mateikaitė-Pipirienė, Alison Rosier, Linda E. Keyes, Peter Paal, Marija Andjelkovic, Beth A. Beidleman, Mia Derstine, Jacqueline Pichler Hefti, David Hillebrandt, Lenka Horakova, and Dominique Jean; for the UIAA MedCom Writing Group on Women's Health in the Mountains. Frostbite and mortality in mountaineering women: a scoping review-UIAA Medical Commission recommendations. <i>High Alt Med Biol</i>. 24:247-258, 2023. <b><i>Background:</i></b> The harsh environment of high altitudes (HA) poses many serious health risks for mountaineers, including cold injuries and death. The aim of this work was to review whether female mountaineers are at special risk for frostbite or death at HA compared with their male counterparts. <b><i>Methods:</i></b> The UIAA Medical Commission convened an international author team to review women's health issues at HA and to publish updated recommendations. Pertinent literature from PubMed and Cochrane was identified with additional publications found by hand search. The primary search focus was for articles assessing cold injuries and death in women mountaineers at HA. <b><i>Results:</i></b> We reviewed the literature and identified 20 relevant studies: 2 studies on frostbite at HA, plus 7 studies and 1 report for death at HA. An additional 10 studies about frostbite at low altitude were included. We found that female mountaineers at HA were at lower risk of death than their male counterparts, but sex differences in frostbite were inconclusive. <b><i>Conclusions:</i></b> The frequency of cold injuries and mortality in female mountaineers is not yet well studied, and the studies that have been published tend to lack precise exposure data. More studies and registries with sex-differentiated data are needed.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41199354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aerobic Exercise Training Under Normobaric Hypoxic Conditions to Improve Glucose and Lipid Metabolism in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis. 在常压缺氧条件下进行有氧运动训练以改善超重和肥胖者的葡萄糖和脂质代谢:系统回顾与元分析》。
IF 1.6 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-12-01 DOI: 10.1089/ham.2022.0099
Hai Guo, Linjie Cheng, Dilihumaier Duolikun, Qiaoling Yao

Guo, Hai, Linjie Cheng, Dilihumaier Duolikun, and Qiaoling Yao. Aerobic exercise training under normobaric hypoxic conditions to improve glucose and lipid metabolism in overweight and obese individuals: a systematic review and meta-analysis. High Alt Med Biol. 24:312-320, 2023. Background: Obesity is a critical public health issue around the world, reaching epidemic proportions in some countries. However, only a few studies have examined the effects of hypoxic training on metabolic parameters in an obese population. This systematic review and meta-analysis aimed to determine the effects of aerobic exercise training under normobaric hypoxic conditions versus normoxic training in improving glucose and lipid metabolism in obese individuals. Methods: A systematic search of PubMed, EMBASE, Web of Science, and Wan Fang databases (up to August 2021) was performed to identify randomized controlled trials (RCTs) of overweight or obese human subjects eligible for inclusion. Main study endpoints were changes in body mass index (BMI), waist/hip (W/H) ratio, leptin, blood glucose and insulin levels, as well as blood lipids between hypoxic and normoxic conditioning. Results: Fourteen RCTs with a total of 413 subjects qualified for inclusion. Pooled analyses revealed that BMI (d = 0.38), W/H ratio (d = 0), blood glucose (d = 0.01), and triglyceride (d = -2.27) were not significantly different between aerobic exercise training under hypoxic and normoxic conditions. However, significant differences were found in heart rate at rest (d = -4.50) between aerobic exercise training under hypoxic versus normoxic conditions. Conclusions: In conclusion, no significant benefits were noted in aerobic exercise training under hypoxic conditions over normoxic conditions in overweight or obese individuals. However, the maximum training heart rate mm was significantly higher under hypoxic conditions than under normoxic conditions. Future studies with larger samples controlling for exercise-related parameters, and addressing the potential modifying effects of level of hypoxia, sex, or age on the role of hypoxic exercise training are warranted. PROSPERO registration number: CRD42020221680.

郭海、程林杰、迪力哈买尔-多力坤和姚巧玲。常压缺氧条件下的有氧运动训练改善超重和肥胖者的糖脂代谢:系统综述和荟萃分析》。24:312-320, 2023.背景:肥胖症是全世界一个严重的公共卫生问题,在一些国家已达到流行病的程度。然而,只有少数研究探讨了缺氧训练对肥胖人群代谢参数的影响。本系统综述和荟萃分析旨在确定常压缺氧条件下的有氧运动训练与常压缺氧训练对改善肥胖人群葡萄糖和脂质代谢的影响。研究方法对 PubMed、EMBASE、Web of Science 和万方数据库(截至 2021 年 8 月)进行系统检索,以确定符合纳入条件的超重或肥胖受试者的随机对照试验(RCT)。主要研究终点为低氧和常氧条件下体重指数(BMI)、腰围/臀围(W/H)比值、瘦素、血糖和胰岛素水平以及血脂的变化。研究结果14项研究共有413名受试者符合纳入条件。汇总分析显示,在低氧和常氧条件下进行有氧运动训练,BMI(d = 0.38)、W/H 比值(d = 0)、血糖(d = 0.01)和甘油三酯(d = -2.27)没有显著差异。然而,有氧运动训练在缺氧和正常缺氧条件下的静息心率(d = -4.50)有明显差异。结论:总之,对于超重或肥胖的人来说,在低氧条件下进行有氧运动训练比在常氧条件下进行有氧运动训练没有明显的益处。不过,缺氧条件下的最大训练心率毫米数明显高于常氧条件下的最大训练心率毫米数。未来的研究需要更多的样本,控制与运动相关的参数,并探讨缺氧程度、性别或年龄对缺氧运动训练作用的潜在调节作用。PROSPERO 注册号:CRD42020221680。
{"title":"Aerobic Exercise Training Under Normobaric Hypoxic Conditions to Improve Glucose and Lipid Metabolism in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis.","authors":"Hai Guo, Linjie Cheng, Dilihumaier Duolikun, Qiaoling Yao","doi":"10.1089/ham.2022.0099","DOIUrl":"10.1089/ham.2022.0099","url":null,"abstract":"<p><p>Guo, Hai, Linjie Cheng, Dilihumaier Duolikun, and Qiaoling Yao. Aerobic exercise training under normobaric hypoxic conditions to improve glucose and lipid metabolism in overweight and obese individuals: a systematic review and meta-analysis. <i>High Alt Med Biol.</i> 24:312-320, 2023. <b><i>Background:</i></b> Obesity is a critical public health issue around the world, reaching epidemic proportions in some countries. However, only a few studies have examined the effects of hypoxic training on metabolic parameters in an obese population. This systematic review and meta-analysis aimed to determine the effects of aerobic exercise training under normobaric hypoxic conditions versus normoxic training in improving glucose and lipid metabolism in obese individuals. <b><i>Methods:</i></b> A systematic search of PubMed, EMBASE, Web of Science, and Wan Fang databases (up to August 2021) was performed to identify randomized controlled trials (RCTs) of overweight or obese human subjects eligible for inclusion. Main study endpoints were changes in body mass index (BMI), waist/hip (W/H) ratio, leptin, blood glucose and insulin levels, as well as blood lipids between hypoxic and normoxic conditioning. <b><i>Results:</i></b> Fourteen RCTs with a total of 413 subjects qualified for inclusion. Pooled analyses revealed that BMI (<i>d</i> = 0.38), W/H ratio (<i>d</i> = 0), blood glucose (<i>d</i> = 0.01), and triglyceride (<i>d</i> = -2.27) were not significantly different between aerobic exercise training under hypoxic and normoxic conditions. However, significant differences were found in heart rate at rest (<i>d</i> = -4.50) between aerobic exercise training under hypoxic versus normoxic conditions. <b><i>Conclusions:</i></b> In conclusion, no significant benefits were noted in aerobic exercise training under hypoxic conditions over normoxic conditions in overweight or obese individuals. However, the maximum training heart rate mm was significantly higher under hypoxic conditions than under normoxic conditions. Future studies with larger samples controlling for exercise-related parameters, and addressing the potential modifying effects of level of hypoxia, sex, or age on the role of hypoxic exercise training are warranted. PROSPERO registration number: CRD42020221680.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138829423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ganoderma lucidum Induces Myogenesis Markers to Avert Damage to Skeletal Muscles in Rats Exposed to Hypobaric Hypoxia. 灵芝诱导肌肉生成标志物,避免低压缺氧对大鼠骨骼肌造成损伤
IF 1.6 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-12-01 Epub Date: 2021-06-17 DOI: 10.1089/ham.2020.0172
Arti Jatwani, Rajkumar Tulsawani

Jatwani, Arti, and Rajkumar Tulsawani. Ganoderma lucidum induces myogenesis markers to avert damage to skeletal muscles in rats exposed to hypobaric hypoxia. High Alt Med Biol. 24:287-295, 2023. Background: Hypobaric hypoxia (HH) has been reported to induce skeletal muscle loss and impair myogenesis. Aqueous extract of G. lucidum (AqGL) contains bioactive metabolites attributed to various pharmacological effects. In this study, protective effect of AqGL in ameliorating muscle mass loss following acute HH has been reported. Materials and Methods: Male Sprague-Dawley rats were divided into following five groups of six rats in each group: unexposed control (Group 1), 6 hours of HH exposure (Group 2), 6 hours of HH exposure+AqGL extract 50 mg/kg body weight (BW) (Group 3), 6 hours of HH exposure+AqGL extract 100 mg/kg BW (Group 4), and 6 hours of HH exposure+AqGL extract 200 mg/kg BW (Group 5). Experimental animals from all groups, except Group, 1 were exposed to HH, simulated altitude of 25,000 ft for 6 hours. After exposure period, gastrocnemius muscle was collected, weighed, and morphological, biochemical, and molecular markers were analyzed. Results: HH-exposed rat muscle showed significant (p < 0.05) increase in oxidative stress markers (reactive oxygen species & malondialdehyde), which was concomitant with decrease in its mass compared to controls. AqGL treatment significantly (p < 0.05) prevented muscle oxidative stress, restored reduced glutathione content, reduced protein carbonyl content and advanced oxidation protein product, and restored muscle mass loss at effective dose of 100 mg/kg BW. Furthermore, AqGL supplementation enhanced Myf5 (p < 0.01), MyoD (p < 0.01), MyoG (p < 0.05), and Mrf4 (nonsignificantly), brain-derived neurotrophic factor (p < 0.01), and interleukin 6 (p < 0.01) expression along with restoration of tumor necrosis factor alpha (p < 0.001) and myostatin (p < 0.05) in hypoxia-exposed muscle, evidencing induction of myogenesis markers. Moreover, histological analysis showed increased myocyte number; nuclei shifted toward the periphery in the treatment group supporting muscle regeneration. Conclusion: AqGL supplementation attenuates muscle mass loss by preventing oxidative stress and inducing modulation in myogenesis markers under HH environment.

Jatwani, Arti 和 Rajkumar Tulsawani。灵芝诱导肌肉生成标志物以避免暴露于低压缺氧环境中的大鼠骨骼肌受损。24:287-295, 2023.背景:据报道,低压缺氧(HH)会诱发骨骼肌损失并损害肌生成。绿藻水提取物(AqGL)含有生物活性代谢物,具有多种药理作用。本研究报告了 AqGL 在改善急性 HH 后肌肉质量损失方面的保护作用。材料和方法:雄性 Sprague-Dawley 大鼠分为以下五组,每组六只:未暴露对照组(第 1 组)、暴露于 HH 6 小时组(第 2 组)、暴露于 HH 6 小时+AqGL 提取物 50 毫克/千克体重组(第 3 组)、暴露于 HH 6 小时+AqGL 提取物 100 毫克/千克体重组(第 4 组)和暴露于 HH 6 小时+AqGL 提取物 200 毫克/千克体重组(第 5 组)。除第 1 组外,其他各组的实验动物均暴露于模拟海拔 25,000 英尺的 HH 中 6 小时。暴露期结束后,收集腓肠肌并称重,分析形态学、生物化学和分子标记物。结果在 HH 环境下,补充 AqGL 可通过防止氧化应激和诱导调节肌肉生成标记物来减轻肌肉质量的损失。
{"title":"<i>Ganoderma lucidum</i> Induces Myogenesis Markers to Avert Damage to Skeletal Muscles in Rats Exposed to Hypobaric Hypoxia.","authors":"Arti Jatwani, Rajkumar Tulsawani","doi":"10.1089/ham.2020.0172","DOIUrl":"10.1089/ham.2020.0172","url":null,"abstract":"<p><p>Jatwani, Arti, and Rajkumar Tulsawani. <i>Ganoderma lucidum</i> induces myogenesis markers to avert damage to skeletal muscles in rats exposed to hypobaric hypoxia. <i>High Alt Med Biol</i>. 24:287-295, 2023. <b><i>Background:</i></b> Hypobaric hypoxia (HH) has been reported to induce skeletal muscle loss and impair myogenesis. Aqueous extract of <i>G. lucidum</i> (AqGL) contains bioactive metabolites attributed to various pharmacological effects. In this study, protective effect of AqGL in ameliorating muscle mass loss following acute HH has been reported. <b><i>Materials and Methods:</i></b> Male Sprague-Dawley rats were divided into following five groups of six rats in each group: unexposed control (Group 1), 6 hours of HH exposure (Group 2), 6 hours of HH exposure+AqGL extract 50 mg/kg body weight (BW) (Group 3), 6 hours of HH exposure+AqGL extract 100 mg/kg BW (Group 4), and 6 hours of HH exposure+AqGL extract 200 mg/kg BW (Group 5). Experimental animals from all groups, except Group, 1 were exposed to HH, simulated altitude of 25,000 ft for 6 hours. After exposure period, gastrocnemius muscle was collected, weighed, and morphological, biochemical, and molecular markers were analyzed. <b><i>Results:</i></b> HH-exposed rat muscle showed significant (<i>p</i> < 0.05) increase in oxidative stress markers (reactive oxygen species & malondialdehyde), which was concomitant with decrease in its mass compared to controls. AqGL treatment significantly (<i>p</i> < 0.05) prevented muscle oxidative stress, restored reduced glutathione content, reduced protein carbonyl content and advanced oxidation protein product, and restored muscle mass loss at effective dose of 100 mg/kg BW. Furthermore, AqGL supplementation enhanced Myf5 (<i>p</i> < 0.01), MyoD (<i>p</i> < 0.01), MyoG (<i>p</i> < 0.05), and Mrf4 (nonsignificantly), brain-derived neurotrophic factor (<i>p</i> < 0.01), and interleukin 6 (<i>p</i> < 0.01) expression along with restoration of tumor necrosis factor alpha (<i>p</i> < 0.001) and myostatin (<i>p</i> < 0.05) in hypoxia-exposed muscle, evidencing induction of myogenesis markers. Moreover, histological analysis showed increased myocyte number; nuclei shifted toward the periphery in the treatment group supporting muscle regeneration. <b><i>Conclusion:</i></b> AqGL supplementation attenuates muscle mass loss by preventing oxidative stress and inducing modulation in myogenesis markers under HH environment.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39244480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Biochemical Study Between L-Carnosine and β-Alanine in Amelioration of Hypobaric Hypoxia-Induced Skeletal Muscle Protein Loss. 左旋肉碱与β-丙氨酸在改善低压缺氧诱导的骨骼肌蛋白质损失方面的生化比较研究
IF 1.6 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-12-01 Epub Date: 2023-08-28 DOI: 10.1089/ham.2023.0014
Richa Rathor, Sukanya Srivastava, Geetha Suryakumar

Rathor, Richa, Sukanya Srivastava, and Geetha Suryakumar. A comparative biochemical study between L-carnosine and β-alanine in amelioration of hypobaric hypoxia-induced skeletal muscle protein loss. High Alt Med Biol. 24:302-311, 2023. Background: Carnosine (CAR; β-alanyl-L-histidine), a biologically active dipeptide is known for its unique pH-buffering capacity, metal chelating activity, and antioxidant and antiglycation property. β-Alanine (ALA) is a nonessential amino acid and used to enhance performance and cognitive functions. Hypobaric hypoxia (HH)-induced muscle protein loss is regulated by multifaceted signaling pathways. The present study investigated the beneficial effects of CAR and ALA against HH-associated muscle loss. Methodology: Simulated HH exposure was performed in an animal decompression chamber. Gastric oral administration of CAR (50 mg·kg-1) and ALA (450 mg·kg-1) were given daily for 3 days and at the end of the treatment, hindlimb skeletal muscle tissue was excised for western blot and biochemical assays. Results: Cosupplementation of CAR and ALA alone was able to ameliorate the hypoxia-induced inflammation, oxidative stress (FOXO), ER stress (GRP-78), and atrophic signaling (MuRF-1) in the skeletal muscles. Creatinine phospho kinase activity and apoptosis were also decreased in CAR- and ALA-supplemented rats. However, CAR showed enhanced protection in HH-induced muscle loss as CAR supplementation was able to enhance protein concentration, body weight, and decreased the protein oxidation and ALA administration was not able to restore the same. Conclusions: Hence, the present comprehensive study supports the fact that CAR (50 mg·kg-1) is more beneficial as compared with ALA (450 mg·kg-1) in ameliorating the hypoxia-induced skeletal muscle loss.

Rathor、Richa、Sukanya Srivastava 和 Geetha Suryakumar。左旋肉碱和β-丙氨酸在改善低压缺氧诱导的骨骼肌蛋白质损失方面的生化比较研究。24:302-311, 2023.背景:卡诺辛(CAR;β-丙氨酰-L-组氨酸)是一种具有生物活性的二肽,因其独特的 pH 缓冲能力、金属螯合活性、抗氧化和抗糖化特性而闻名。β-丙氨酸(ALA)是一种非必需氨基酸,可用于提高机能和认知功能。低压缺氧(HH)诱导的肌肉蛋白质流失受多方面信号通路的调控。本研究探讨了 CAR 和 ALA 对 HH 相关肌肉损失的有益影响。研究方法:在动物减压舱中进行模拟 HH 暴露。每天口服 CAR(50 毫克-千克-1)和 ALA(450 毫克-千克-1),连续 3 天,治疗结束后切除后肢骨骼肌组织进行 Western 印迹和生化检测。结果单独补充 CAR 和 ALA 能够改善缺氧诱导的骨骼肌炎症、氧化应激(FOXO)、ER 应激(GRP-78)和萎缩信号转导(MuRF-1)。补充 CAR 和 ALA 的大鼠肌酸磷酸激酶活性和细胞凋亡也有所降低。然而,CAR对HH诱导的肌肉损失显示出更强的保护作用,因为补充CAR能够提高蛋白质浓度、增加体重并降低蛋白质氧化,而补充ALA则无法恢复相同的效果。结论:因此,本综合研究证实,与 ALA(450 毫克/千克-1)相比,CAR(50 毫克/千克-1)更有利于改善缺氧诱导的骨骼肌损失。
{"title":"A Comparative Biochemical Study Between L-Carnosine and β-Alanine in Amelioration of Hypobaric Hypoxia-Induced Skeletal Muscle Protein Loss.","authors":"Richa Rathor, Sukanya Srivastava, Geetha Suryakumar","doi":"10.1089/ham.2023.0014","DOIUrl":"10.1089/ham.2023.0014","url":null,"abstract":"<p><p>Rathor, Richa, Sukanya Srivastava, and Geetha Suryakumar. A comparative biochemical study between L-carnosine and β-alanine in amelioration of hypobaric hypoxia-induced skeletal muscle protein loss. <i>High Alt Med Biol</i>. 24:302-311, 2023. <b><i>Background:</i></b> Carnosine (CAR; β-alanyl-L-histidine), a biologically active dipeptide is known for its unique pH-buffering capacity, metal chelating activity, and antioxidant and antiglycation property. β-Alanine (ALA) is a nonessential amino acid and used to enhance performance and cognitive functions. Hypobaric hypoxia (HH)-induced muscle protein loss is regulated by multifaceted signaling pathways. The present study investigated the beneficial effects of CAR and ALA against HH-associated muscle loss. <b><i>Methodology:</i></b> Simulated HH exposure was performed in an animal decompression chamber. Gastric oral administration of CAR (50 mg·kg<sup>-1</sup>) and ALA (450 mg·kg<sup>-1</sup>) were given daily for 3 days and at the end of the treatment, hindlimb skeletal muscle tissue was excised for western blot and biochemical assays. <b><i>Results:</i></b> Cosupplementation of CAR and ALA alone was able to ameliorate the hypoxia-induced inflammation, oxidative stress (FOXO), ER stress (GRP-78), and atrophic signaling (MuRF-1) in the skeletal muscles. Creatinine phospho kinase activity and apoptosis were also decreased in CAR- and ALA-supplemented rats. However, CAR showed enhanced protection in HH-induced muscle loss as CAR supplementation was able to enhance protein concentration, body weight, and decreased the protein oxidation and ALA administration was not able to restore the same. <b><i>Conclusions:</i></b> Hence, the present comprehensive study supports the fact that CAR (50 mg·kg<sup>-1</sup>) is more beneficial as compared with ALA (450 mg·kg<sup>-1</sup>) in ameliorating the hypoxia-induced skeletal muscle loss.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10485858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Mountain Sickness and High Altitude Cerebral Edema in Women: A Scoping Review-UIAA Medical Commission Recommendations. 女性急性山地病和高海拔地区脑水肿:UIAA医学委员会建议的范围审查。
IF 1.6 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-12-01 Epub Date: 2023-10-23 DOI: 10.1089/ham.2023.0043
Mia Derstine, Dominique Jean, Beth A Beidleman, Jacqueline Pichler Hefti, David Hillebrandt, Lenka Horakova, Susi Kriemler, Kastė Mateikaitė-Pipirienė, Peter Paal, Alison J Rosier, Marija Andjelkovic, Linda E Keyes

Derstine, Mia, Dominique Jean, Beth A. Beidleman, Jacqueline Pichler Hefti, David Hillebrandt, Lenka Horakova, Susi Kriemler, Kasté Mateikaité-Pipiriené, Peter Paal, Alison Rosier, Marija Andjelkovic, and Linda E. Keyes. Acute mountain sickness and high altitude cerebral edema in women: A scoping review-UIAA Medical Commission recommendations. High Alt Med Biol. 24:259-267, 2023. Background: Acute mountain sickness (AMS) and high-altitude cerebral edema (HACE) are illnesses associated with rapid ascent to altitudes over 2,500 m in unacclimatized lowlanders. The aim of this scoping review is to summarize the current knowledge on sex differences in the epidemiology, pathophysiology, symptomatology, and treatment of AMS and HACE, especially in women. Methods and Results: The UIAA Medical Commission convened an international author team to review women's health issues at high altitude and to publish updated recommendations. Pertinent literature from PubMed and Cochrane was identified by keyword search combinations (including AMS, HACE, and high altitude), with additional publications found by hand search. The primary search focus was for articles assessing lowland women sojourning at high altitude. Results: The literature search yielded 7,165 articles, 37 of which were ultimately included. The majority of publications included did not find women at increased risk for AMS or HACE. There was extremely limited sex-specific data on risk factors or treatment. Conclusions: There is a limited amount of data on female-specific findings regarding AMS and HACE, with most publications addressing only prevalence or incidence with regard to sex. As such, general prevention and treatment strategies for AMS and HACE should be used regardless of sex.

Derstine、Mia、Dominique Jean、Beth A.Beidleman、Jacqueline Pichler Hefti、David Hillebrandt、Lenka Horakova、Susi Kriemler、KastéMateikaité-Pipiriené、Peter Paal、Alison Rosier、Marija Andjelkovic和Linda E.Keyes。女性急性山地病和高海拔脑水肿:UIAA医学委员会建议的范围审查。High Alt-Med Biol.00:000-0002023。背景:急性山地病(AMS)和高海拔脑水肿(HACE)是与快速上升到2500以上海拔有关的疾病 m生活在未适应的低地。本范围综述的目的是总结目前关于AMS和HACE的流行病学、病理生理学、症状学和治疗方面的性别差异的知识,尤其是在女性中。方法和结果:UIAA医学委员会召集了一个国际作者小组,审查高海拔地区妇女的健康问题,并发布最新建议。PubMed和Cochrane的相关文献通过关键词搜索组合(包括AMS、HACE和高海拔)进行识别,并通过手工搜索找到其他出版物。主要搜索重点是评估在高海拔地区逗留的低地妇女的文章。结果:文献检索得到7165篇文章,其中37篇最终被收录。纳入的大多数出版物没有发现女性患AMS或HACE的风险增加。关于危险因素或治疗的性别特异性数据极其有限。结论:关于AMS和HACE的女性特异性发现的数据有限,大多数出版物只涉及性别的患病率或发病率。因此,无论性别如何,都应使用AMS和HACE的一般预防和治疗策略。
{"title":"Acute Mountain Sickness and High Altitude Cerebral Edema in Women: A Scoping Review-UIAA Medical Commission Recommendations.","authors":"Mia Derstine, Dominique Jean, Beth A Beidleman, Jacqueline Pichler Hefti, David Hillebrandt, Lenka Horakova, Susi Kriemler, Kastė Mateikaitė-Pipirienė, Peter Paal, Alison J Rosier, Marija Andjelkovic, Linda E Keyes","doi":"10.1089/ham.2023.0043","DOIUrl":"10.1089/ham.2023.0043","url":null,"abstract":"<p><p>Derstine, Mia, Dominique Jean, Beth A. Beidleman, Jacqueline Pichler Hefti, David Hillebrandt, Lenka Horakova, Susi Kriemler, Kasté Mateikaité-Pipiriené, Peter Paal, Alison Rosier, Marija Andjelkovic, and Linda E. Keyes. Acute mountain sickness and high altitude cerebral edema in women: A scoping review-UIAA Medical Commission recommendations. <i>High Alt Med Biol</i>. 24:259-267, 2023. <b><i>Background:</i></b> Acute mountain sickness (AMS) and high-altitude cerebral edema (HACE) are illnesses associated with rapid ascent to altitudes over 2,500 m in unacclimatized lowlanders. The aim of this scoping review is to summarize the current knowledge on sex differences in the epidemiology, pathophysiology, symptomatology, and treatment of AMS and HACE, especially in women. <b><i>Methods and Results:</i></b> The UIAA Medical Commission convened an international author team to review women's health issues at high altitude and to publish updated recommendations. Pertinent literature from PubMed and Cochrane was identified by keyword search combinations (including AMS, HACE, and high altitude), with additional publications found by hand search. The primary search focus was for articles assessing lowland women sojourning at high altitude. Results: The literature search yielded 7,165 articles, 37 of which were ultimately included. The majority of publications included did not find women at increased risk for AMS or HACE. There was extremely limited sex-specific data on risk factors or treatment. <b><i>Conclusions:</i></b> There is a limited amount of data on female-specific findings regarding AMS and HACE, with most publications addressing only prevalence or incidence with regard to sex. As such, general prevention and treatment strategies for AMS and HACE should be used regardless of sex.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49690197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal Manifestations in High Altitude. 高海拔地区的视网膜表现。
IF 1.6 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-12-01 Epub Date: 2023-08-01 DOI: 10.1089/ham.2023.0051
Meenu Dangi, Arnab Sadhukhan, Poninder Kumar, S Bandopadhyay, Vijay K Sharma, V K Patra, Manu Chaudhary, Vipin Rana

Dangi, Meenu, Arnab Sadhukhan, Poninder Kumar, S. Bandopadhayay, Vijay K. Sharma, V.K. Patra, Manu Chaudhary, and Vipin Rana. Retinal manifestations in high altitude. High Alt Med Biol. 24:296-301, 2023. Aim: To study the high altitude (HA)-related retinal manifestations among security personnel and thus to provide new insights into the characteristics and mechanisms of retinopathy. Materials and Methods: This was a multicentric, nonrandomized prospective observational and descriptive study. We studied 54 security personnel over 1 year, who were referred from HA areas of northern India and north-eastern India for ocular problems. Complete coagulation profile was performed among patients with vascular occlusion. Results: There were total of 54 patients with ages ranging from 22 to 55 years. HA retinopathy was noticed in 28 patients: central retinal vein occlusion (6 patients), branch retinal vein occlusion (4 patients), branch retinal artery occlusion (1 patient), central retinal artery occlusion (4 patients), ocular ischemic syndrome (1 patient), central serous chorioretinopathy (7 patients), acetazolamide-induced maculopathy (1 patient), and solar retinopathy (2 patients). Along with an increased hematocrit, serum homocysteine was raised in the majority of vascular occlusions. The mean age was 38.16 years, the mean altitude was 14,716 ft, and the mean duration of stay was 11.2 weeks. Conclusion: Hypobaric hypoxia due to HA is a potential risk for HA retinopathy and associated vascular occlusions. Aside from increased hematocrit, hyperhomocysteinemia is a potential cause of vascular occlusions.

Dangi、Meenu、Arnab Sadhukhan、Poninder Kumar、S. Bandopadhayay、Vijay K. Sharma、V.K. Patra、Manu Chaudhary 和 Vipin Rana。高海拔地区的视网膜表现。24:296-301, 2023.目的:研究保安人员与高海拔(HA)相关的视网膜表现,从而为视网膜病变的特征和机制提供新的见解。材料与方法:这是一项多中心、非随机的前瞻性观察和描述性研究。我们对 54 名保安人员进行了为期一年的研究,他们都是因眼部问题从印度北部和印度东北部的医管局地区转诊过来的。对血管闭塞患者进行了全面的凝血功能检查。结果:共有 54 名患者,年龄在 22 至 55 岁之间。28 名患者出现了 HA 视网膜病变:视网膜中央静脉闭塞(6 人)、视网膜分支静脉闭塞(4 人)、视网膜分支动脉闭塞(1 人)、视网膜中央动脉闭塞(4 人)、眼部缺血综合征(1 人)、中央浆液性脉络膜视网膜病变(7 人)、乙酰唑胺诱发的黄斑病变(1 人)和日光性视网膜病变(2 人)。大多数血管闭塞患者在血细胞比容升高的同时,血清同型半胱氨酸也升高。平均年龄为 38.16 岁,平均海拔为 14,716 英尺,平均住院时间为 11.2 周。结论HA导致的低压缺氧是HA视网膜病变和相关血管闭塞的潜在风险。除了血细胞比容升高外,高同型半胱氨酸血症也是血管闭塞的潜在原因。
{"title":"Retinal Manifestations in High Altitude.","authors":"Meenu Dangi, Arnab Sadhukhan, Poninder Kumar, S Bandopadhyay, Vijay K Sharma, V K Patra, Manu Chaudhary, Vipin Rana","doi":"10.1089/ham.2023.0051","DOIUrl":"10.1089/ham.2023.0051","url":null,"abstract":"<p><p>Dangi, Meenu, Arnab Sadhukhan, Poninder Kumar, S. Bandopadhayay, Vijay K. Sharma, V.K. Patra, Manu Chaudhary, and Vipin Rana. Retinal manifestations in high altitude. <i>High Alt Med Biol</i>. 24:296-301, 2023. <b><i>Aim:</i></b> To study the high altitude (HA)-related retinal manifestations among security personnel and thus to provide new insights into the characteristics and mechanisms of retinopathy. <b><i>Materials and Methods:</i></b> This was a multicentric, nonrandomized prospective observational and descriptive study. We studied 54 security personnel over 1 year, who were referred from HA areas of northern India and north-eastern India for ocular problems. Complete coagulation profile was performed among patients with vascular occlusion. <b><i>Results:</i></b> There were total of 54 patients with ages ranging from 22 to 55 years. HA retinopathy was noticed in 28 patients: central retinal vein occlusion (6 patients), branch retinal vein occlusion (4 patients), branch retinal artery occlusion (1 patient), central retinal artery occlusion (4 patients), ocular ischemic syndrome (1 patient), central serous chorioretinopathy (7 patients), acetazolamide-induced maculopathy (1 patient), and solar retinopathy (2 patients). Along with an increased hematocrit, serum homocysteine was raised in the majority of vascular occlusions. The mean age was 38.16 years, the mean altitude was 14,716 ft, and the mean duration of stay was 11.2 weeks. <b><i>Conclusion:</i></b> Hypobaric hypoxia due to HA is a potential risk for HA retinopathy and associated vascular occlusions. Aside from increased hematocrit, hyperhomocysteinemia is a potential cause of vascular occlusions.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9922487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Appetite, Hypoxia, and Acute Mountain Sickness: A 10-Hour Normobaric Hypoxic Chamber Study. 食欲、缺氧和急性晕山症:10 小时常压低氧舱研究。
IF 1.6 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-12-01 Epub Date: 2023-08-11 DOI: 10.1089/ham.2023.0009
Holly Barclay, Saptarshi Mukerji, Bengt Kayser, Jui-Lin Fan

Barclay, Holly, Saptarshi Mukerji, Bengt Kayser, and Jui-Lin Fan. Appetite, hypoxia and acute mountain sickness: A 10-hour normobaric hypoxic chamber study. High Alt Med Biol. 24:329-335, 2023. Background: The effects of hypoxia and acute mountain sickness (AMS) on appetite and food preferences are moot, especially during the early phase of hypoxic exposure. We examined the effects of a 10-hour hypoxic exposure on appetite and food preference. Methods: We assessed appetite (hunger, satisfaction, fullness, perceived appetite, and lost appetite), food preferences (sweet, salty, savory, and fatty), and AMS (Lake Louise score) with questionnaires in 27 healthy individuals (13 women) across 10-hour exposures to normobaric normoxia (fraction of inspired O2 [FiO2]: 0.21) and normobaric hypoxia (FiO2: 0.12, equivalent of 5,000 m) in a randomized, single-blinded manner. Results and Conclusions: Compared with normoxia, hypoxia decreased hunger and appetite (p = 0.040 and <0.001, respectively), which was mediated by a decreased desire for sweet, salty, and fatty foods (p < 0.05 for all). AMS was associated with a decreased desire for sweet (R = -0.438, p = 0.032) and salty foods (R = -0.460, p = 0.024) and greater loss of appetite (R = -0.619, p = 0.018). Our findings suggest that acute hypoxia rapidly suppresses appetite and that AMS development further amplifies anorexia. Clinical Trial Registration Number: ACTRN12618000548235.

Barclay, Holly, Saptarshi Mukerji, Bengt Kayser, and Jui-Lin Fan.食欲、缺氧和急性高山反应:10小时常压缺氧室研究。24:329-335, 2023.背景:缺氧和急性高山病(AMS)对食欲和食物偏好的影响尚无定论,尤其是在缺氧暴露的早期阶段。我们研究了10小时缺氧暴露对食欲和食物偏好的影响。研究方法我们以随机、单盲的方式,对 27 名健康人(13 名女性)在 10 小时常压常氧(通气氧气分数 [FiO2]:0.21)和常压低氧(FiO2:0.12,相当于 5,000 米)暴露过程中的食欲(饥饿感、满足感、饱腹感、感知食欲和食欲不振)、食物偏好(甜、咸、咸味和脂肪)和 AMS(路易斯湖评分)进行了问卷评估。结果和结论:与常压缺氧相比,缺氧会降低饥饿感和食欲(p = 0.040 和 p R = -0.438,p = 0.032),减少咸味食物(R = -0.460,p = 0.024)和更大程度的食欲不振(R = -0.619,p = 0.018)。我们的研究结果表明,急性缺氧会迅速抑制食欲,而 AMS 的发展会进一步加重厌食症。临床试验注册号ACTRN12618000548235。
{"title":"Appetite, Hypoxia, and Acute Mountain Sickness: A 10-Hour Normobaric Hypoxic Chamber Study.","authors":"Holly Barclay, Saptarshi Mukerji, Bengt Kayser, Jui-Lin Fan","doi":"10.1089/ham.2023.0009","DOIUrl":"10.1089/ham.2023.0009","url":null,"abstract":"<p><p>Barclay, Holly, Saptarshi Mukerji, Bengt Kayser, and Jui-Lin Fan. Appetite, hypoxia and acute mountain sickness: A 10-hour normobaric hypoxic chamber study. <i>High Alt Med Biol</i>. 24:329-335, 2023. <b><i>Background:</i></b> The effects of hypoxia and acute mountain sickness (AMS) on appetite and food preferences are moot, especially during the early phase of hypoxic exposure. We examined the effects of a 10-hour hypoxic exposure on appetite and food preference. <b><i>Methods:</i></b> We assessed appetite (hunger, satisfaction, fullness, perceived appetite, and lost appetite), food preferences (sweet, salty, savory, and fatty), and AMS (Lake Louise score) with questionnaires in 27 healthy individuals (13 women) across 10-hour exposures to normobaric normoxia (fraction of inspired O<sub>2</sub> [FiO<sub>2</sub>]: 0.21) and normobaric hypoxia (F<sub>i</sub>O<sub>2</sub>: 0.12, equivalent of 5,000 m) in a randomized, single-blinded manner. <b><i>Results and Conclusions:</i></b> Compared with normoxia, hypoxia decreased hunger and appetite (<i>p</i> = 0.040 and <0.001, respectively), which was mediated by a decreased desire for sweet, salty, and fatty foods (<i>p</i> < 0.05 for all). AMS was associated with a decreased desire for sweet (<i>R</i> = -0.438, <i>p</i> = 0.032) and salty foods (<i>R</i> = -0.460, <i>p</i> = 0.024) and greater loss of appetite (<i>R</i> = -0.619, <i>p</i> = 0.018). Our findings suggest that acute hypoxia rapidly suppresses appetite and that AMS development further amplifies anorexia. Clinical Trial Registration Number: ACTRN12618000548235.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10351047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Termination of Cardiopulmonary Resuscitation in Mountain Rescue: A Scoping Review and ICAR MedCom 2023 Recommendations. 山地救援中终止心肺复苏:范围界定综述和ICAR MedCom 2023建议。
IF 1.6 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-12-01 Epub Date: 2023-09-22 DOI: 10.1089/ham.2023.0068
Viktor Lugnet, Miles McDonough, Les Gordon, Mercedes Galindez, Nicolas Mena Reyes, Alison Sheets, Ken Zafren, Peter Paal

Lugnet, Viktor, Miles McDonough, Les Gordon, Mercedes Galindez, Nicolas Mena Reyes, Alison Sheets, Ken Zafren, and Peter Paal. Termination of cardiopulmonary resuscitation in mountain rescue: a scoping review and ICAR MedCom 2023 recommendations. High Alt Med Biol. 24:274-286, 2023. Background: In 2012, the International Commission for Mountain Emergency Medicine (ICAR MedCom) published recommendations for termination of cardiopulmonary resuscitation (CPR) in mountain rescue. New developments have necessitated an update. This is the 2023 update for termination of CPR in mountain rescue. Methods: For this scoping review, we searched the PubMed and Cochrane libraries, updated the recommendations, and obtained consensus approval within the writing group and the ICAR MedCom. Results: We screened a total of 9,102 articles, of which 120 articles met the inclusion criteria. We developed 17 recommendations graded according to the strength of recommendation and level of evidence. Conclusions: Most of the recommendations from 2012 are still valid. We made minor changes regarding the safety of rescuers and responses to primary or traumatic cardiac arrest. The criteria for termination of CPR remain unchanged. The principal changes include updated recommendations for mechanical chest compression, point of care ultrasound (POCUS), extracorporeal life support (ECLS) for hypothermia, the effects of water temperature in drowning, and the use of burial times in avalanche rescue.

Lugnet、Viktor、Miles McDonough、Les Gordon、Mercedes Galndez、Nicolas Mena Reyes、Alison Sheets、Ken Zafren和Peter Paal。山地救援中心肺复苏的终止:范围审查和ICAR MedCom 2023建议。High Alt-Med Biol 00:000-0002023。背景:2012年,国际山地急救医学委员会(ICAR-MedCom)发布了关于在山地救援中终止心肺复苏(CPR)的建议。新的事态发展需要更新。这是2023年山地救援中终止心肺复苏术的最新消息。方法:在这项范围界定审查中,我们搜索了PubMed和Cochrane图书馆,更新了建议,并获得了写作小组和ICAR MedCom的一致批准。结果:我们共筛选了9102篇文章,其中120篇符合纳入标准。我们制定了17项建议,根据建议的强度和证据水平进行分级。结论:2012年的大多数建议仍然有效。我们对救援人员的安全性以及对原发性或创伤性心脏骤停的反应进行了细微的改变。终止心肺复苏术的标准保持不变。主要变化包括机械胸部按压、护理点超声(POCUS)、体温过低的体外生命支持(ECLS)、溺水时水温的影响以及雪崩救援中埋葬时间的使用的最新建议。
{"title":"Termination of Cardiopulmonary Resuscitation in Mountain Rescue: A Scoping Review and ICAR MedCom 2023 Recommendations.","authors":"Viktor Lugnet, Miles McDonough, Les Gordon, Mercedes Galindez, Nicolas Mena Reyes, Alison Sheets, Ken Zafren, Peter Paal","doi":"10.1089/ham.2023.0068","DOIUrl":"10.1089/ham.2023.0068","url":null,"abstract":"<p><p>Lugnet, Viktor, Miles McDonough, Les Gordon, Mercedes Galindez, Nicolas Mena Reyes, Alison Sheets, Ken Zafren, and Peter Paal. Termination of cardiopulmonary resuscitation in mountain rescue: a scoping review and ICAR MedCom 2023 recommendations. <i>High Alt Med Biol</i>. 24:274-286, 2023. <b><i>Background:</i></b> In 2012, the International Commission for Mountain Emergency Medicine (ICAR MedCom) published recommendations for termination of cardiopulmonary resuscitation (CPR) in mountain rescue. New developments have necessitated an update. This is the 2023 update for termination of CPR in mountain rescue. <b><i>Methods:</i></b> For this scoping review, we searched the PubMed and Cochrane libraries, updated the recommendations, and obtained consensus approval within the writing group and the ICAR MedCom. <b><i>Results:</i></b> We screened a total of 9,102 articles, of which 120 articles met the inclusion criteria. We developed 17 recommendations graded according to the strength of recommendation and level of evidence. <b><i>Conclusions:</i></b> Most of the recommendations from 2012 are still valid. We made minor changes regarding the safety of rescuers and responses to primary or traumatic cardiac arrest. The criteria for termination of CPR remain unchanged. The principal changes include updated recommendations for mechanical chest compression, point of care ultrasound (POCUS), extracorporeal life support (ECLS) for hypothermia, the effects of water temperature in drowning, and the use of burial times in avalanche rescue.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41113407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor: Sensitivity and Specificity of the Lake Louise Score: What Should We Focus On? 致编辑的信:路易斯湖评分的敏感性和特异性:我们应该关注什么?
IF 1.6 4区 医学 Q4 BIOPHYSICS Pub Date : 2023-12-01 Epub Date: 2023-08-07 DOI: 10.1089/ham.2023.0079
Sanjeeb S Bhandari
{"title":"<i>Letter to the Editor:</i> Sensitivity and Specificity of the Lake Louise Score: What Should We Focus On?","authors":"Sanjeeb S Bhandari","doi":"10.1089/ham.2023.0079","DOIUrl":"10.1089/ham.2023.0079","url":null,"abstract":"","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10343693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
High altitude medicine & biology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1