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2007 6th International Special Topic Conference on Information Technology Applications in Biomedicine最新文献

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Comparison of Adaptive and Fixed Segmentation in Different Calculation Methods of Electroencephalogram Time-series Entropy for Estimating Depth of Anesthesia 脑电时间序列熵不同计算方法中自适应分割与固定分割的比较
B. Ahmadi, R. Aimrfattahi, Ehsan Negahbani, M. Mansouri, Mina Taheri
This paper proposes a combined method including adaptive segmentation and time-series Shannon entropy of electroencephalograms (EEG) to monitor depth of anesthesia (DOA). The entropy of a single channel EEG was computed through various methods of quantization. These methods are different in number of bins associated to the whole range of amplitude. The EEG data was captured in both ICU and operating room and different anesthetic drugs, including propofol and isoflurane were used. Due to the non-stationary nature of EEG signal, adaptive segmentation methods seem to have better results. Our adaptive windowing methods consist of variance and auto correlation (ACF) based methods. We have compared the results of fixed and adaptive windowing in different methods of calculating entropy in order to estimate DOA. Coefficient of determination (R ) was used as a measure of correlation between the predictors and BIS index to evaluate our proposed methods. The results show that entropy decreases with decreasing DOA. In ICU, our proposed method reveals better performance than previous works. In both ICU and operating room, the results indicate the superiority of our method, especially applying adaptive segmentation. The mixture of adaptive windowing methods with different methods of calculating entropy would result in an outstanding performance.
提出了一种结合自适应分割和时间序列香农熵的脑电图监测麻醉深度的方法。通过各种量化方法计算单通道脑电信号的熵。这些方法在与整个振幅范围相关联的箱数上是不同的。分别在ICU和手术室采集脑电图数据,并使用异丙酚和异氟醚等麻醉药物。由于脑电信号的非平稳性,自适应分割方法似乎具有较好的效果。我们的自适应加窗方法包括基于方差和基于自相关的方法。我们比较了固定窗和自适应窗在不同熵计算方法下的结果,以估计DOA。决定系数(R)被用来衡量预测因子与BIS指数之间的相关性,以评估我们提出的方法。结果表明,熵随DOA的减小而减小。在ICU中,我们所提出的方法比以往的工作显示出更好的性能。在ICU和手术室中,结果表明了该方法的优越性,特别是应用自适应分割。将自适应加窗方法与不同的熵值计算方法相结合,可以获得较好的性能。
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引用次数: 1
Mathematical Modeling of Human Blood Clotting Formation 人体凝血形成的数学模型
S. Ravanshadi, M. Jahed
Over the last two decades, mathematical modeling has become a popular tool in study of blood coagulation. This paper describes the coagulation pathway and presents a mathematical model for the generation of blood clot in human vasculature. Parameters of interest in this study include procoagulants and anticoagulants whose activity may be enhanced by various activator enzymes. The process of human blood clotting involves a complex interaction between these parameters and continuous time and state processes. In this work, we propose to model these highly inter-relational processes by a set of nonlinear chemical rate equations. We have modeled this process as a dynamical system, as chemical reaction of blood clot is similar to the Michaclis-Mcntcn kinetics. Simulation result reveals that for zero concentration of certain activators, blood clot can't embark and for positive concentration of those activators, the clot is formed. In our analytical model some particular anticoagulants are studied and their role in the clotting process is evaluated. Furthermore simulation results for low concentrations of APC, the active protein C, which acts as a anticoagulant, states formation of blood clot.
在过去的二十年里,数学建模已经成为研究血液凝固的一种流行工具。本文描述了凝血途径,提出了人体血管中血凝块生成的数学模型。本研究感兴趣的参数包括促凝剂和抗凝剂,其活性可通过各种激活酶增强。人体血液凝固过程涉及这些参数与连续时间和状态过程之间复杂的相互作用。在这项工作中,我们建议通过一组非线性化学速率方程来模拟这些高度相互关联的过程。我们将这一过程建模为一个动力学系统,因为血凝块的化学反应类似于micaclis - mcntcn动力学。仿真结果表明,当某些活化剂的浓度为零时,血凝块无法形成;当某些活化剂的浓度为正时,血凝块形成。在我们的分析模型中,研究了一些特殊的抗凝剂,并评估了它们在凝血过程中的作用。此外,模拟结果表明,低浓度的APC,作为抗凝血剂的活性蛋白C,状态形成血栓。
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引用次数: 4
Development of a Ubiquitous Wearable Unit and its Application to Cycling Exercise 无所不在可穿戴设备的研制及其在自行车运动中的应用
D. Watanabe, K. Yamashita, T. Kiryu
We embedded control function as well as monitoring physical activity in a wearable unit for controlling several types of powered health promotion machines on standalone and on-site. The unit consisted of a Linux board with an on-board A-D converter that measures 5 channels of biosignals including surface EMG and ECG. The interfaces were wired and wireless LAN ports for connecting networks. Besides, Web-server and a LCD unit were provided for browsing the results at any place. We applied the unit for controlling the cycle ergometer workload in the room and the power-assisted bicycle in the field for live subjects, while monitoring physical activity and estimating fatigue by a fuzzy inference. The results showed a possibility for control of powered health promotion machines by heart rate and muscle activity on-site.
我们在一个可穿戴设备中嵌入控制功能和监测身体活动,用于在独立和现场控制几种类型的动力健康促进机。该装置由一个带有板载a - d转换器的Linux板组成,可测量5个通道的生物信号,包括体表肌电信号和心电信号。接口是用于连接网络的有线和无线局域网端口。此外,还提供了web服务器和LCD单元,以便在任何地方浏览结果。我们将该单元应用于控制室内的自行车劳力计工作量和现场的电动辅助自行车,同时监测身体活动并通过模糊推理估计疲劳。结果表明,通过心率和肌肉活动来控制动力健康促进机是可能的。
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引用次数: 0
Influences of Meat Organization on Intensity Distribution in Magnetic Resonance Images 肉类组织对磁共振图像强度分布的影响
Y. Kato, M. Ichinoseki, T. Kamada, A. Kumagai, K. Onuma, R. Himeno
The chemical composition and tissue structure of meats determine the quality of food products. Nondestructive techniques such as magnetic resonance imaging (MRI) are ideal for monitoring meat quality. Meat organization influences the intensity and phase of MR images. In this study, the influence of meat fat content and tenderness on the intensity of MR images was evaluated using the following samples: chicken breast (CB), chicken thigh (CT), porcine fillet (PF), porcine thigh (PT), and porcine stomach (PS). Considerable differences in fat content and tenderness - parameters influenced by intramuscular connective tissue - were observed in these meat samples. Significant differences in mean image intensity were observed between the CB and CT samples of chicken meat. Further, with the exception of the PS sample, significant differences in mean intensity were also observed between the porcine meat samples. On the contrary, no significant differences in the standard deviation and standard error of the mean of image intensity were produced by meat organization. These results indicate that mean intensity may be a useful parameter to evaluate meat organization.
肉类的化学成分和组织结构决定了食品的质量。磁共振成像(MRI)等非破坏性技术是监测肉类质量的理想方法。肉组织影响MR图像的强度和相位。本研究以鸡胸肉(CB)、鸡腿肉(CT)、猪里脊肉(PF)、猪腿肉(PT)和猪胃(PS)为研究对象,评估了肉脂肪含量和嫩度对MR图像强度的影响。在这些肉类样品中观察到脂肪含量和嫩度(受肌内结缔组织影响的参数)的相当大的差异。在鸡肉的CB和CT样品之间观察到平均图像强度的显著差异。此外,除PS样品外,猪肉样品之间的平均强度也存在显著差异。相反,肉类组织在图像强度均值的标准差和标准误差方面没有显著差异。这些结果表明,平均强度可以作为评价肉质组织的一个有用参数。
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引用次数: 0
A light-weighted, Low-cost and Wireless ECG Monitor Design based on TinyOS Operating System 基于TinyOS操作系统的轻型、低成本无线心电监护仪设计
Wong Kiing-Ing
Due to the recent active research activities in the area of wireless sensor networks (WSN), the development and realization of a light-weighted, low-cost and wireless electrocardiogram (ECG) monitor has become feasible. In this paper, we propose an ECG monitor design based on a commercially available WSN device. The device utilizes 868 MHz ISM license free frequency band and operates on TinyOS operating system. The ECG signal from patients is detected and radioed to a PC for monitoring. This paper validates our approach and suggests the feasibility of future enhancements.
由于近年来无线传感器网络领域的研究活跃,开发和实现一种轻便、低成本的无线心电监护仪已经成为可能。在本文中,我们提出了一种基于市售WSN设备的心电监护仪设计。设备使用868mhz的ISM免license频段,操作系统为TinyOS。检测到患者的心电信号,并将其发送到PC机进行监测。本文验证了我们的方法,并提出了未来增强的可行性。
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引用次数: 19
Compensation for two specific types of artifact in pulse wave using a Kalman filter 用卡尔曼滤波器补偿脉冲波中两种特定类型的伪影
M. Yarita, N. Kobayashi, S. Takeda, Toshiyo Tamura
An algorithm is proposed to interpolate the pulse wave during the measurement of SpO2 by using Kalman filter identification of autoregression (AR) coefficients, Kalman filter interpolation, and a fixed-interval smoother. This combined algorithm picks up the pulse rate smoothly from pulse waves contaminated by two specific artifact types: respiration artifact and sporadic body movement artifact.
提出了一种利用卡尔曼滤波识别自回归(AR)系数、卡尔曼滤波插值和定间隔平滑对SpO2测量过程中的脉冲波进行插值的算法。该算法从两种特定的伪影(呼吸伪影和零星的身体运动伪影)污染的脉搏波中平滑地提取出脉搏率。
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引用次数: 5
ECG, EOG detection from helmet based system 基于头盔系统的ECG, EOG检测
Yun Seong Kim, Haet Bit Lee, Jung Soo Kim, H. Baek, M. S. Ryu, K. Park
In the military environment there are many harsh working conditions compare to the normal working place. Many activity can be tiring and compromise a soldier's condition and prove fatal, not only to the individual, but to the team and their operation as well. The same principles apply to the work of Are fighters and miners. Many problems in their work places are caused by worker's mistake due to their fatigue or unconsciousness behavior like a drowsiness. So to monitor and feedback to them is very essential. Despite the importance of the monitoring the health condition, device for this purpose was seldom developed yet. In the former study we proposed helmet based system for measuring biomedical signals. In this paper detecting method for ECG, EOG will be presented using helmet based system and their differences between normal and drowsiness status.
在军事环境中,与正常工作场所相比,有许多恶劣的工作条件。许多活动可能会使人疲劳,损害士兵的状况,不仅对个人,而且对整个团队和他们的行动都是致命的。同样的原则也适用于战斗人员和矿工的工作。他们工作场所的许多问题都是由于工人的疲劳或无意识行为(如困倦)造成的。所以对他们进行监控和反馈是非常必要的。尽管健康状况监测具有重要意义,但用于健康状况监测的设备却很少。在之前的研究中,我们提出了基于头盔的生物医学信号测量系统。本文将介绍基于头盔系统的心电、眼电信号的检测方法,以及它们在正常和困倦状态下的区别。
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引用次数: 16
Reproducing Difficulties of Airway Management on Patients with Restricted Mouth Opening using the WKA-1 WKA-1在限制开口患者气道管理中的再现困难
Y. Noh, M. Segawa, A. Shimomura, H. Ishii, J. Solis, K. Hatake, A. Takanishi
Airway management is provided by emergency medical technicians or anesthetists in order to save unconscious patients under emergency situations. Even though airway management is basic skill, there may be some difficulties while performing airway management to patients with abnormalities. Therefore, it is important to train medical students to perform such a task on patients with abnormalities. Recently, many companies are developing airway training mannequins designed to reproduce the conditions of the airway management procedure. However, such training devices cannot provide any quantitative information of the training progress so that few amount of feedback can be provided to trainees. For this purpose, we have proposed the development of an airway management training system which has been designed to embed sensors into a conventional mannequin. As a result, we have developed the Waseda-Kyotokagaku airway No. 1 (WKA-1). In this paper, the WKA-1 was used to reproduce the airway management on patients with abnormalities on jaw opening. For this purpose, we have added an array of springs to simulate those abnormalities. Then, we proposed an experiment to detect the differences on performances among doctors (anesthetist) while performing the airway management in patients with and without abnormalities on the jaw opening. Both cases were analyzed quantitatively by using the functionalities of the WKA-1. From the experimental results, we could find a statistically significant difference between both cases.
气道管理由紧急医疗技术人员或麻醉师提供,以便在紧急情况下挽救失去知觉的病人。尽管气道管理是一项基本技能,但在对异常患者进行气道管理时可能存在一些困难。因此,培养医学生对异常患者执行这样的任务是很重要的。最近,许多公司正在开发气道训练人体模型,旨在重现气道管理程序的条件。然而,这种培训设备无法提供任何关于培训进度的定量信息,因此给受训者的反馈很少。为此,我们建议开发一种气道管理训练系统,该系统被设计成将传感器嵌入传统的人体模型中。因此,我们开发了Waseda-Kyotokagaku 1号气道(WKA-1)。本文采用WKA-1对颌骨开口异常患者气道管理进行再现。为此,我们添加了一组弹簧来模拟这些异常情况。然后,我们提出了一项实验来检测医生(麻醉师)在对有和无颌骨张开异常的患者进行气道管理时的表现差异。使用WKA-1的功能对这两种情况进行定量分析。从实验结果中,我们可以发现两种情况之间有统计学上的显著差异。
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引用次数: 2
Basic Study on Fat Thickness Estimation Using Electrical Bio-Impedance Tomography 电生物阻抗断层成像脂肪厚度估计的基础研究
M. Kinoshita, H. Aoki, K. Koshiji
We carried out the numerical analysis in order to examine fat thickness estimation for applying the electrical bio-impedance tomography. Recently, the increase of obese subjects becomes a large social problem. For obese prevention, it is said that health care by appropriate exercise is necessary. For example, it seems to be useful for health care by knowing adhesion condition of the subcutaneous fat in the femoral region, because the metabolism rate and the exercise ability can be grasped. Electrical bio-Impedance Tomography is one of the cheapest ways in order to realize a tomography. We can obtain a conductivity distribution in human body. EIT utilizes relationship between the injection current and surface potential distribution depending on the conductivity difference. Then, we carried out the examination by finite difference method in order to establish the technique for estimating the subcutaneous fat thickness in the femoral region by application of the electrical bio-impedance tomography.
我们进行了数值分析,以检验应用电生物阻抗断层成像的脂肪厚度估计。近年来,肥胖人群的增加已成为一个重大的社会问题。为了预防肥胖,据说通过适当的运动进行保健是必要的。例如,了解股区域皮下脂肪的粘连情况似乎对保健有帮助,因为可以掌握代谢率和运动能力。电生物阻抗层析成像是实现层析成像最经济的方法之一。我们可以得到人体电导率的分布。EIT利用注入电流和表面电位分布之间的关系,这取决于电导率差。然后,我们进行了有限差分法检查,以建立应用电生物阻抗断层扫描估计股骨区域皮下脂肪厚度的技术。
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引用次数: 1
Virtual Surgery Planning of Breast Reconstruction Using Deformation Modeling and Curve Shape Approximation 基于变形建模和曲线形状逼近的乳房重建虚拟手术规划
Pengfei Huang, Lixu Gu, Jiarong Yan, Hua Xu, Jiasheng Dong
In this paper, a virtual breast plastic surgery planning method is proposed, which reconstructs the breast after excision for certain diseases such as cancer. In order to achieve a rational result, we calculate shape, area, volume and depth of the skin and muscle for the reconstruction, based on the other healthy breast. The steps are as follows: 1) input breast's MRI data of patient; 2) get the healthy breast using balloon segmentation algorithm and get triangle mesh on breast surface; 3) flatten the triangulated skin of breast using deformable model to attain the shape and volume of the flap for breast reconstruction; 4) calculate the approximate curve shape of flap. Other methods such as mesh smoothing and cutting of triangulated surface are also introduced. The doctors validation and evaluation process are also provided to ensure the robust and stable result of virtual surgery planning.
本文提出了一种虚拟乳房整形手术计划方法,该方法可以在某些疾病(如癌症)切除后重建乳房。为了达到一个合理的结果,我们在其他健康乳房的基础上计算重建的皮肤和肌肉的形状、面积、体积和深度。步骤如下:1)输入患者乳腺MRI数据;2)利用球囊分割算法得到健康乳房,在乳房表面得到三角形网格;3)利用可变形模型对乳房三角皮肤进行压平,得到乳房再造皮瓣的形状和体积;4)计算皮瓣的近似曲线形状。同时还介绍了网格平滑和三角曲面切割等方法。提供了医生验证和评估过程,以确保虚拟手术计划结果的鲁棒性和稳定性。
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引用次数: 2
期刊
2007 6th International Special Topic Conference on Information Technology Applications in Biomedicine
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