Pub Date : 2007-12-26DOI: 10.1109/ITAB.2007.4407350
V. Kremen, L. Lhotská
Complex fractionated atrial electrograms (CFAEs) represent the electrophysiologic substrate for atrial fibrillation (AF). Progress in signal processing algorithms to identify CFAEs sites is crucial for the development of AF ablation strategies. Individual signal complexes in CFAEs reflect electrical activity of electrophysiologic substrate at given time. We developed a novel algorithm for automated search of individual signal complexes in CFAEs. This algorithm based on wavelet transform enables to describe CFAEs in a novel way and helps to classify CFAEs level of complexity (degree of fractionation). The method was tested using a representative set of 1.5s A-EGMs (n = 113) ranked by an expert into 4 categories: 1 -organized atrial activity; 2 -mild; 3 -intermediate; 4 -high degree of fractionation. Individual signal complexes were marked by an expert in every A-EGM in the dataset. This ranking was used as gold standard for comparison with the novel automatic search method. Following hit rates were achieved by performed automatic search on representative set of data: category 1: 100%, category 2: 98.2%, category 3: 92.06%, category 4: 63.89%. These results indicate that wavelet signal decomposition could carry high level of predictive information about the state of electrophysiologic substrate for AF.
复杂分割心房电图(CFAEs)代表心房颤动(AF)的电生理底物。识别CFAEs位点的信号处理算法的进展对于AF消融策略的发展至关重要。cfae中单个信号复合物反映了特定时间电生理底物的电活动。我们开发了一种新的算法来自动搜索cfae中的单个信号复合物。该算法基于小波变换，能够以一种新颖的方式描述cfae，并有助于对cfae的复杂程度(分块程度)进行分类。该方法采用一组代表性的1.5s a - egm (n = 113)进行测试，由专家将其分为4类:1 -有组织的心房活动;2温和;3中间;4 -分馏度高。单个信号复合体由数据集中每个A-EGM中的专家标记。这个排名被用作与新的自动搜索方法进行比较的金标准。通过对代表性数据集进行自动搜索，获得了以下命中率:类别1:100%，类别2:98.2%，类别3:92.06%，类别4:63.89%。这些结果表明，小波信号分解可以对AF的电生理底物状态进行高水平的预测。
{"title":"Novel approach to search for individual signal complexes in complex fractionated atrial electrograms using wavelet transform","authors":"V. Kremen, L. Lhotská","doi":"10.1109/ITAB.2007.4407350","DOIUrl":"https://doi.org/10.1109/ITAB.2007.4407350","url":null,"abstract":"Complex fractionated atrial electrograms (CFAEs) represent the electrophysiologic substrate for atrial fibrillation (AF). Progress in signal processing algorithms to identify CFAEs sites is crucial for the development of AF ablation strategies. Individual signal complexes in CFAEs reflect electrical activity of electrophysiologic substrate at given time. We developed a novel algorithm for automated search of individual signal complexes in CFAEs. This algorithm based on wavelet transform enables to describe CFAEs in a novel way and helps to classify CFAEs level of complexity (degree of fractionation). The method was tested using a representative set of 1.5s A-EGMs (n = 113) ranked by an expert into 4 categories: 1 -organized atrial activity; 2 -mild; 3 -intermediate; 4 -high degree of fractionation. Individual signal complexes were marked by an expert in every A-EGM in the dataset. This ranking was used as gold standard for comparison with the novel automatic search method. Following hit rates were achieved by performed automatic search on representative set of data: category 1: 100%, category 2: 98.2%, category 3: 92.06%, category 4: 63.89%. These results indicate that wavelet signal decomposition could carry high level of predictive information about the state of electrophysiologic substrate for AF.","PeriodicalId":129874,"journal":{"name":"2007 6th International Special Topic Conference on Information Technology Applications in Biomedicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131225769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-12-26DOI: 10.1109/ITAB.2007.4407407
Abhay Raman
We are a population that is getting progressively older. As we age, the need for better quality and efficient healthcare services at home and hospitals is becoming significantly more important. With the increasing cost of providing care-giver based monitoring services for patients and an ageing of the nurse and caregiver population itself, remote patient monitoring (RPM) has the potential to improve the quality of health services and lower the total cost of providing healthcare to chronic care patients by avoiding unnecessary hospitalizations, and ensuring urgent care is afforded to people who are in need of it. The commercial availability of monitoring units to measure vitals such as blood pressure, glucose and weight are assisting in the adoption of RHM. In this paper, the author discusses the enforcement of privacy and confidentiality through security measures and practices. The author end the discussion by outlining additional areas for research and suggestions for future work.
{"title":"Enforcing Privacy through Security in Remote Patient Monitoring Ecosystems","authors":"Abhay Raman","doi":"10.1109/ITAB.2007.4407407","DOIUrl":"https://doi.org/10.1109/ITAB.2007.4407407","url":null,"abstract":"We are a population that is getting progressively older. As we age, the need for better quality and efficient healthcare services at home and hospitals is becoming significantly more important. With the increasing cost of providing care-giver based monitoring services for patients and an ageing of the nurse and caregiver population itself, remote patient monitoring (RPM) has the potential to improve the quality of health services and lower the total cost of providing healthcare to chronic care patients by avoiding unnecessary hospitalizations, and ensuring urgent care is afforded to people who are in need of it. The commercial availability of monitoring units to measure vitals such as blood pressure, glucose and weight are assisting in the adoption of RHM. In this paper, the author discusses the enforcement of privacy and confidentiality through security measures and practices. The author end the discussion by outlining additional areas for research and suggestions for future work.","PeriodicalId":129874,"journal":{"name":"2007 6th International Special Topic Conference on Information Technology Applications in Biomedicine","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114450416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-12-26DOI: 10.1109/ITAB.2007.4407357
H. Koga, Y. Usuda, M. Matsuno, Y. Ogura, H. Ishii, J. Solis, A. Takanishi, A. Katsumata
It is well known that the massage therapy is useful for the rehabilitation of various diseases. Although various apparatus have been developed for the massage of the torso and limbs, a machine to perform precise massage therapy to maxillofacial region is not developed yet. Therefore, we developed a robot system that provides massage therapy to maxillofacial region. The name of our newly developed robot was WAO-1. WAO-1 has been designed to perform appropriate massage to the patients with dry mouth, etc. WAO-1 is composed by two 6-degree of freedom arms with plungers attached at the end-effectors. The massage is applied to the patient by controlling the force and position of the plunger (virtual compliance). As a preliminary step of the clinical application, a simulation therapy of robotic massage to stimulate salivary flow from parotid gland was performed. The dynamic force on patient's head during the massage using WAO-1 was evaluated. The results suggested that WAO-1 could perform equivalent massage to human hand. We expect that WAO-1 will be useful to provide massage therapy to several patients with oral health problems. This will aim in reducing the therapy costs due to the need of human efforts when long-time therapies are needed.
{"title":"Development of Oral Rehabilitation Robot for Massage Therapy","authors":"H. Koga, Y. Usuda, M. Matsuno, Y. Ogura, H. Ishii, J. Solis, A. Takanishi, A. Katsumata","doi":"10.1109/ITAB.2007.4407357","DOIUrl":"https://doi.org/10.1109/ITAB.2007.4407357","url":null,"abstract":"It is well known that the massage therapy is useful for the rehabilitation of various diseases. Although various apparatus have been developed for the massage of the torso and limbs, a machine to perform precise massage therapy to maxillofacial region is not developed yet. Therefore, we developed a robot system that provides massage therapy to maxillofacial region. The name of our newly developed robot was WAO-1. WAO-1 has been designed to perform appropriate massage to the patients with dry mouth, etc. WAO-1 is composed by two 6-degree of freedom arms with plungers attached at the end-effectors. The massage is applied to the patient by controlling the force and position of the plunger (virtual compliance). As a preliminary step of the clinical application, a simulation therapy of robotic massage to stimulate salivary flow from parotid gland was performed. The dynamic force on patient's head during the massage using WAO-1 was evaluated. The results suggested that WAO-1 could perform equivalent massage to human hand. We expect that WAO-1 will be useful to provide massage therapy to several patients with oral health problems. This will aim in reducing the therapy costs due to the need of human efforts when long-time therapies are needed.","PeriodicalId":129874,"journal":{"name":"2007 6th International Special Topic Conference on Information Technology Applications in Biomedicine","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121697885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-12-26DOI: 10.1109/ITAB.2007.4407423
D. Fotiadis, T. Exarchos, M. Tsipouras, C. Papaloukas
In this paper we present a methodology for biosequence classification, which employs sequential pattern mining and optimization algorithms. In the first stage, a sequential pattern mining algorithm is applied to a set of biological sequences and the sequential patterns are extracted. Then, the score of each pattern with respect to each sequence is calculated using a scoring function and the score of each class under consideration is estimated. The scores of the patterns and classes are updated, multiplied by a weight. In the second stage an optimization technique is employed to calculate the weight values to achieve the optimal classification accuracy. The methodology is applied in the protein class and fold prediction problem. Extensive evaluation is carried out, using a dataset obtained from the Protein Data Bank.
{"title":"Biosequence Classification using Sequential Pattern Mining and Optimization","authors":"D. Fotiadis, T. Exarchos, M. Tsipouras, C. Papaloukas","doi":"10.1109/ITAB.2007.4407423","DOIUrl":"https://doi.org/10.1109/ITAB.2007.4407423","url":null,"abstract":"In this paper we present a methodology for biosequence classification, which employs sequential pattern mining and optimization algorithms. In the first stage, a sequential pattern mining algorithm is applied to a set of biological sequences and the sequential patterns are extracted. Then, the score of each pattern with respect to each sequence is calculated using a scoring function and the score of each class under consideration is estimated. The scores of the patterns and classes are updated, multiplied by a weight. In the second stage an optimization technique is employed to calculate the weight values to achieve the optimal classification accuracy. The methodology is applied in the protein class and fold prediction problem. Extensive evaluation is carried out, using a dataset obtained from the Protein Data Bank.","PeriodicalId":129874,"journal":{"name":"2007 6th International Special Topic Conference on Information Technology Applications in Biomedicine","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122545594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-12-26DOI: 10.1109/ITAB.2007.4407421
Dominique Gauthier, Y. Akay, R. Paden, W. Pavlicek, F. David, John K Fortuin, Richard W Sweeney, Metin Lee, Akay
Numerous studies based on the spectral analysis of diastolic sounds showed an increase in the high frequency portion of the spectrum for patients with coronary artery disease (CAD) compared with normal patients. The overall goal of this study is to detect the presence of coronary artery disease in patients using a noninvasive and inexpensive approach. A commercially available electronic stethoscope was used to record the diastolic heart sounds from patients diagnosed with or without CAD based on their coronary angiography examination. The Fast Fourier Transform, a widely used signal processing method, was then implemented on the diastolic segments. The power ratios of the energy above 130 Hz to the energy below 130 Hz were calculated for normal and abnormal patients and compared. Results furthermore confirmed that patients with CAD have more energy in the higher portion of their spectrum, resulting in higher power ratios than for normal patients (p < 0.05). This approach led to a sensitivity of 71%, a specificity of 83% and an overall accuracy of 73.3% using an optimal threshold ratio of 1.5. These results suggest that the proposed system could be used in clinics as part of standard physical examinations.
{"title":"Spectral Analysis of Heart Sounds Associated With Coronary Occlusions","authors":"Dominique Gauthier, Y. Akay, R. Paden, W. Pavlicek, F. David, John K Fortuin, Richard W Sweeney, Metin Lee, Akay","doi":"10.1109/ITAB.2007.4407421","DOIUrl":"https://doi.org/10.1109/ITAB.2007.4407421","url":null,"abstract":"Numerous studies based on the spectral analysis of diastolic sounds showed an increase in the high frequency portion of the spectrum for patients with coronary artery disease (CAD) compared with normal patients. The overall goal of this study is to detect the presence of coronary artery disease in patients using a noninvasive and inexpensive approach. A commercially available electronic stethoscope was used to record the diastolic heart sounds from patients diagnosed with or without CAD based on their coronary angiography examination. The Fast Fourier Transform, a widely used signal processing method, was then implemented on the diastolic segments. The power ratios of the energy above 130 Hz to the energy below 130 Hz were calculated for normal and abnormal patients and compared. Results furthermore confirmed that patients with CAD have more energy in the higher portion of their spectrum, resulting in higher power ratios than for normal patients (p < 0.05). This approach led to a sensitivity of 71%, a specificity of 83% and an overall accuracy of 73.3% using an optimal threshold ratio of 1.5. These results suggest that the proposed system could be used in clinics as part of standard physical examinations.","PeriodicalId":129874,"journal":{"name":"2007 6th International Special Topic Conference on Information Technology Applications in Biomedicine","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127243584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-12-26DOI: 10.1109/ITAB.2007.4407368
T. Suenaga, A. Takada
This paper proposes a layered architecture for medical information exchanges using internet mail protocols. This architecture realizes smooth and flexible communication between different systems and equipments. In medical fields, every system must pay attention to much security measures for medical information exchange via public network. However, there are innumerable medical information systems, medical equipments, and also data exchange specifications. Therefore, such differentia disturbs to construct smooth secure communication between different systems. The proposed system has three layers architecture to reduce such differentia. A prototype system implemented web-mail interface based on proposed platform. Experimental result shows, proposed platform can realize smooth and flexible secure communication.
{"title":"Layered Secure Medical Information Exchange Platform","authors":"T. Suenaga, A. Takada","doi":"10.1109/ITAB.2007.4407368","DOIUrl":"https://doi.org/10.1109/ITAB.2007.4407368","url":null,"abstract":"This paper proposes a layered architecture for medical information exchanges using internet mail protocols. This architecture realizes smooth and flexible communication between different systems and equipments. In medical fields, every system must pay attention to much security measures for medical information exchange via public network. However, there are innumerable medical information systems, medical equipments, and also data exchange specifications. Therefore, such differentia disturbs to construct smooth secure communication between different systems. The proposed system has three layers architecture to reduce such differentia. A prototype system implemented web-mail interface based on proposed platform. Experimental result shows, proposed platform can realize smooth and flexible secure communication.","PeriodicalId":129874,"journal":{"name":"2007 6th International Special Topic Conference on Information Technology Applications in Biomedicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128886315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-12-26DOI: 10.1109/ITAB.2007.4407359
Bo Zhu, Lixu Gu, Jingsi Zhang
Virtual surgery has drawn a lot of attention during the past few years for its repeatability and low cost. In a virtual surgical environment, collision between organs or between organs and surgical instruments occurs frequently. Therefore, an efficient and stable method is needed to simulate these collision processes. Nevertheless, contrary to rigid solid animation where complete analytical solutions have been found, simulating colliding response process between deformable objects still remains a challenge. In this paper, we present an advanced method to model collision response between tissues. It computes response force and generates an exact contact surface between colliding objects. Our method considers both geometric features such as penetration depth and physical properties such as relative velocity and friction to compute proper collision forces. Further, a breadth-first searching algorithm is applied in distributing these calculated reaction forces in different parts of the object in order to generate exact contact surface between interacting objects. Its application in a minimal invasion virtual surgery is used for case study.
{"title":"A Method for Collision Response between Deformable Objects in Virtual Surgery","authors":"Bo Zhu, Lixu Gu, Jingsi Zhang","doi":"10.1109/ITAB.2007.4407359","DOIUrl":"https://doi.org/10.1109/ITAB.2007.4407359","url":null,"abstract":"Virtual surgery has drawn a lot of attention during the past few years for its repeatability and low cost. In a virtual surgical environment, collision between organs or between organs and surgical instruments occurs frequently. Therefore, an efficient and stable method is needed to simulate these collision processes. Nevertheless, contrary to rigid solid animation where complete analytical solutions have been found, simulating colliding response process between deformable objects still remains a challenge. In this paper, we present an advanced method to model collision response between tissues. It computes response force and generates an exact contact surface between colliding objects. Our method considers both geometric features such as penetration depth and physical properties such as relative velocity and friction to compute proper collision forces. Further, a breadth-first searching algorithm is applied in distributing these calculated reaction forces in different parts of the object in order to generate exact contact surface between interacting objects. Its application in a minimal invasion virtual surgery is used for case study.","PeriodicalId":129874,"journal":{"name":"2007 6th International Special Topic Conference on Information Technology Applications in Biomedicine","volume":"517 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123095778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-12-26DOI: 10.1109/ITAB.2007.4407388
G. Bráz, E. C. da Silva, A.C. de Paiva, A.C. Silva
Female breast cancer is the major cause of death in occidental countries. Efforts in computer vision have been made in order to help improving the diagnostic accuracy by radiologists. We propose a methodology to distinguish Mass and Non-Mass tissues on mammograms. It is based on the computation of geostatistical measures (Moran's Index and Geary's Coefficient) over a multiresolution image representation trough wavelet transform. The computed measures are classified through a Support Vector Machine (SVM). The methodology reaches 98.36% of Specificity, 98.13% of Sensitivity and a rate of 98.24% to discriminate Mass from Non-Mass elements, using the Geary's Coefficient application.
{"title":"Breast Tissues Classification Based on the Application of Geostatistical Features and Wavelet Transform","authors":"G. Bráz, E. C. da Silva, A.C. de Paiva, A.C. Silva","doi":"10.1109/ITAB.2007.4407388","DOIUrl":"https://doi.org/10.1109/ITAB.2007.4407388","url":null,"abstract":"Female breast cancer is the major cause of death in occidental countries. Efforts in computer vision have been made in order to help improving the diagnostic accuracy by radiologists. We propose a methodology to distinguish Mass and Non-Mass tissues on mammograms. It is based on the computation of geostatistical measures (Moran's Index and Geary's Coefficient) over a multiresolution image representation trough wavelet transform. The computed measures are classified through a Support Vector Machine (SVM). The methodology reaches 98.36% of Specificity, 98.13% of Sensitivity and a rate of 98.24% to discriminate Mass from Non-Mass elements, using the Geary's Coefficient application.","PeriodicalId":129874,"journal":{"name":"2007 6th International Special Topic Conference on Information Technology Applications in Biomedicine","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124370957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-12-26DOI: 10.1109/ITAB.2007.4407392
T. Fujimoto, A. Kodabashi, M. Usui, K. Takeuchi, T. Otsubo, K. Nakamura, Y. Higashi, K. Kose, H. Tanaka, M. Sekine, T. Tamura
We investigated the time course of cortical activity in the brain related to cold epidermal touch stimulation at 4 degree Celsius and touch stimulation at a normal temperature of 14 degree Celsius to the palm of the hand in 20 normal human subjects (average age of 29.1plusmn6.0 years), using magneto-encephalography (MEG). The time course of cortical activities with cold touch stimulation to the right palm showed cortical activities in the posterior portion of the posterior cingulate cortex at an average of 214plusmn 101.2 ms before cold touch stimulation, in the ipsilateral somatosensory area at an average of 39.6plusmn37.5 ms, in the contralateral primary somatosensory area at an average of 64.8plusmn28.4 ms, and then in the anterior cingulate cortex, including a portion of the corpus callosum, at an average of 302plusmn126 ms, following cold touch stimulation. It was noted that the time course of cortical activities to cold touch stimulation to the palm showed a difference, compared with normal temperature touch stimulation: cortical activities were observed in the ipsilateral sensory region at an average of 39.6plusmn37.5 ms following cold touch stimulation, but such activities were not observed following normal temperature touch stimulation. On the other hand, there were no significant differences in the time courses of cortical activities in the contralateral primary sensory area and in cingulate regions between the two types of stimulation. The time course of brain activities in response to epidermal stimulation showed no laterality or gender difference.
{"title":"Normal human brain processing of cold stimulation observed by magneto-encephalography","authors":"T. Fujimoto, A. Kodabashi, M. Usui, K. Takeuchi, T. Otsubo, K. Nakamura, Y. Higashi, K. Kose, H. Tanaka, M. Sekine, T. Tamura","doi":"10.1109/ITAB.2007.4407392","DOIUrl":"https://doi.org/10.1109/ITAB.2007.4407392","url":null,"abstract":"We investigated the time course of cortical activity in the brain related to cold epidermal touch stimulation at 4 degree Celsius and touch stimulation at a normal temperature of 14 degree Celsius to the palm of the hand in 20 normal human subjects (average age of 29.1plusmn6.0 years), using magneto-encephalography (MEG). The time course of cortical activities with cold touch stimulation to the right palm showed cortical activities in the posterior portion of the posterior cingulate cortex at an average of 214plusmn 101.2 ms before cold touch stimulation, in the ipsilateral somatosensory area at an average of 39.6plusmn37.5 ms, in the contralateral primary somatosensory area at an average of 64.8plusmn28.4 ms, and then in the anterior cingulate cortex, including a portion of the corpus callosum, at an average of 302plusmn126 ms, following cold touch stimulation. It was noted that the time course of cortical activities to cold touch stimulation to the palm showed a difference, compared with normal temperature touch stimulation: cortical activities were observed in the ipsilateral sensory region at an average of 39.6plusmn37.5 ms following cold touch stimulation, but such activities were not observed following normal temperature touch stimulation. On the other hand, there were no significant differences in the time courses of cortical activities in the contralateral primary sensory area and in cingulate regions between the two types of stimulation. The time course of brain activities in response to epidermal stimulation showed no laterality or gender difference.","PeriodicalId":129874,"journal":{"name":"2007 6th International Special Topic Conference on Information Technology Applications in Biomedicine","volume":"22 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129007947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2007-12-26DOI: 10.1109/ITAB.2007.4407416
Altug AkayI, Andrei Dragomir, A. Yardimci, D. Canatan, Dr. Akif Yesilipek, B. Pogue
beta-thalassemia, an anemic genetic disorder, remains a significant global health issue, especially in the era of globalization where healthcare, economics, and education are more tightly interconnected. Although previous studies focused on the medical aspect of beta-thalassemia and the affects of consanguineous marriages, we investigated what affects the socio-economic geography of beta-thalassemia and how it affects the spread rate using self-organizing maps (SOM) and Sammon mapping. We converted data generated from questionnaires into numerical variables to facilitate the subsequent analysis of how certain variables contribute to beta-thalassemia's spread. We expected a strong correlation among variables (current education and financial status, information availability, neighborhood prevention programs, and treatment affordability). Only 28% of the population contained both high education and high income, thus had the highest awareness. We studied the mapped data and identified relevant variables corresponding to factors affecting the spread rate of beta-thalassemia. We concluded that education directly correlates to beta-thalassemia's spread rate. Education created a ripple effect, affecting other variables. The data supports the idea that a more educated population, combined with aggressive prevention and treatment programs should prevent the spread of beta-thalassemia.
{"title":"Investigating How Social and Economic Geography Affect ß-thalassemia's spread","authors":"Altug AkayI, Andrei Dragomir, A. Yardimci, D. Canatan, Dr. Akif Yesilipek, B. Pogue","doi":"10.1109/ITAB.2007.4407416","DOIUrl":"https://doi.org/10.1109/ITAB.2007.4407416","url":null,"abstract":"beta-thalassemia, an anemic genetic disorder, remains a significant global health issue, especially in the era of globalization where healthcare, economics, and education are more tightly interconnected. Although previous studies focused on the medical aspect of beta-thalassemia and the affects of consanguineous marriages, we investigated what affects the socio-economic geography of beta-thalassemia and how it affects the spread rate using self-organizing maps (SOM) and Sammon mapping. We converted data generated from questionnaires into numerical variables to facilitate the subsequent analysis of how certain variables contribute to beta-thalassemia's spread. We expected a strong correlation among variables (current education and financial status, information availability, neighborhood prevention programs, and treatment affordability). Only 28% of the population contained both high education and high income, thus had the highest awareness. We studied the mapped data and identified relevant variables corresponding to factors affecting the spread rate of beta-thalassemia. We concluded that education directly correlates to beta-thalassemia's spread rate. Education created a ripple effect, affecting other variables. The data supports the idea that a more educated population, combined with aggressive prevention and treatment programs should prevent the spread of beta-thalassemia.","PeriodicalId":129874,"journal":{"name":"2007 6th International Special Topic Conference on Information Technology Applications in Biomedicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130589157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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