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Extended families? Contact expectations and experiences of egg donors donating to previously unknown recipients 大家庭?捐卵者与未知受捐者的联系期望和经验
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-13 DOI: 10.1080/14647273.2023.2292592
Sonja Goedeke, Heather Gamble, Rebecca Thurlow
In New Zealand egg donation is identity-release, and donors may be known to recipients, e.g. family members/friends, or previously unknown e.g. clinic-recruited or sourced through advertising. In t...
在新西兰,卵子捐献是一种身份释放,捐献者可能是受捐者认识的人,如家庭成员/朋友,也可能是以前不认识的人,如诊所招募的人或通过广告寻找的人。在新西兰,捐卵者的身份是公开的。
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引用次数: 0
Response to Hasdemir et al. (2023) COVID-19 vaccinations on menstrual cycle and serum anti-Mullerian hormone levels. 回应 Hasdemir 等人(2023 年)COVID-19 疫苗接种对月经周期和血清抗穆勒氏管激素水平的影响。
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-05-02 DOI: 10.1080/14647273.2023.2200980
Amnuay Kleebayoon, Viroj Wiwanitkit
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引用次数: 0
Association of menstrual blood volume and reproductive outcomes in patients with caesarean scar pregnancy managed using uterine artery embolization and curettage. 采用子宫动脉栓塞和刮宫术治疗的剖腹产瘢痕妊娠患者月经血量与生殖结局的关系。
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-05-08 DOI: 10.1080/14647273.2023.2207746
Guangshao Cao, Ruiqing Liu, Jianwen Liu, Jian Liu, Yuyan Liu, Lupeng Li, Xiaoyang Zhao, Hui Li, Huicun Cao

This study aimed to assess the association of menstrual blood volumes (MBV) and reproductive outcomes in patients after uterine artery embolization (UAE) combined with curettage for caesarean scar pregnancy (CSP). This retrospective observational study enrolled women who underwent UAE plus curettage for CSP at the Interventional Department of Henan Provincial People's Hospital between December 2012 and December 2017. The primary outcome was pregnancy rate and the secondary outcomes were live birth rate (LBR) and interpregnancy interval. This study finally included 37 women (16 women with normal MBV and 21 women with decreased MBV) with pregnancy intention after UAE plus curettage for CSP. The pregnancy rate in women with normal MBV was higher than those with decreased MBV (81.3% vs. 47.6%; P = 0.048). There were no differences between the two groups regarding the interpregnancy interval (18.4 ± 8.7 vs. 22.2 ± 10.0 months, P = 0.233), and LBR (63% vs. 38%, P = 0.191). In conclusion, Women with normal MBV after UAE combined with curettage for CSP management might have a higher pregnancy rate compared with patients with decreased MBV, but there were no differences in LBR between the two groups.

本研究旨在评估子宫动脉栓塞术(UAE)联合刮宫术治疗剖宫产瘢痕妊娠(CSP)患者的月经血量(MBV)与生殖结局的相关性。这项回顾性观察研究纳入了2012年12月至2017年12月期间在河南省人民医院介入科接受UAE加刮宫术治疗CSP的妇女。主要结果为妊娠率,次要结果为活产率(LBR)和孕间期。该研究最终纳入了37名经UAE加刮宫术治疗CSP后有妊娠意向的女性(16名MBV正常女性和21名MBV下降女性)。MBV 正常女性的妊娠率高于 MBV 下降女性(81.3% 对 47.6%;P = 0.048)。两组间的孕间隔(18.4 ± 8.7 个月 vs. 22.2 ± 10.0 个月,P = 0.233)和 LBR(63% vs. 38%,P = 0.191)没有差异。总之,与 MBV 下降的患者相比,UAE 联合刮宫治疗 CSP 后 MBV 正常的女性怀孕率可能更高,但两组患者的 LBR 没有差异。
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引用次数: 0
Endometrial receptivity evaluation using hysteroscopic endometrial gland image recognition. 利用宫腔镜子宫内膜腺体图像识别评估子宫内膜受孕率。
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-03-21 DOI: 10.1080/14647273.2023.2191345
Shi Zheng, Zhu Minbo, Tong Chunya

We investigated the endometrial gland count on hysteroscopic endometrial images in patients undergoing in vitro fertilization and embryo transfer (IVF-ET) to evaluate endometrial receptivity and predict pregnancy outcomes. Since endometrial receptivity and endometrial glands density are strongly influenced by numerous factors, we selected 98 patients who underwent frozen-thawed embryo transfer (FET) in a natural cycle. Within 1-3 menstrual cycles before embryo transfer, hysteroscopic exploration was performed 3-7 days after ovulation. Uterine cavity morphological data were measured, and hysteroscopic endometrial imaging was performed. An endometrial gland opening labelling algorithm was used to recognize and count the endometrial glands. Patients were divided into pregnancy and non-pregnancy groups based on ET outcomes. No significant differences were noted in patients' general information and laboratory parameters, including age, years of infertility, body mass index, anti-Müllerian hormone, endometrial thickness and embryos transferred between the two groups. The number of endometrial glands in the pregnancy group was higher than that in the non-pregnancy group (p < 0.05). Hysteroscopic examination of the uterine cavity and gland counting analysis of images using image recognition software can better indicate endometrial receptivity and improve pregnancy outcomes.

我们研究了接受体外受精和胚胎移植(IVF-ET)的患者在宫腔镜下子宫内膜图像上的子宫内膜腺体数量,以评估子宫内膜的接受能力并预测妊娠结局。由于子宫内膜容受性和子宫内膜腺体密度受多种因素的强烈影响,我们选择了98名在自然周期中接受冷冻解冻胚胎移植(FET)的患者。在胚胎移植前的 1-3 个月经周期内,于排卵后 3-7 天进行宫腔镜检查。测量宫腔形态数据,并进行宫腔镜子宫内膜成像。采用子宫内膜腺体开口标记算法来识别和计数子宫内膜腺体。根据 ET 结果将患者分为妊娠组和非妊娠组。两组患者的一般信息和实验室指标(包括年龄、不孕年数、体重指数、抗穆勒氏激素、子宫内膜厚度和胚胎移植)无明显差异。妊娠组的子宫内膜腺体数量高于非妊娠组(p
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引用次数: 0
Is intrauterine hematoma associated with adverse pregnancy and obstetric outcomes of ART singletons? A systematic review and meta-analysis. 宫内血肿与 ART 单胎的不良妊娠结局和产科结局有关吗?系统回顾和荟萃分析。
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-05-31 DOI: 10.1080/14647273.2023.2213448
Rui Du, Ying Tian, Ai-Juan Shi, Huan-Hua Gu, Yi-Xin Li, Mei Wang

The objective of our meta-analysis was to estimate the effect of intrauterine hematoma (IUH) on obstetric and pregnancy outcomes of assisted reproductive technology (ART) pregnancies. Four electronic databases were searched up to December 2021 to find studies reporting relevant outcomes of ART pregnancies with IUH. Dichotomous data were expressed as odds ratios (OR) with 95% confidence intervals (CI). Continuous data were expressed as weighted mean difference (WMD) with 95% CI. A total of six observational studies were included in this meta-analysis. Our data suggested that IUH in pregnancies achieved by ART are not associated with increased risks of miscarriage, low birth weight, placenta previa, or premature rupture of membranes. Similar birthweight was noted between the two groups. However, IUH was associated with significantly shorter gestational age at delivery (GA) as well as higher risks of preterm birth. Subgroup analyses have found that the presence of retroplacental haematoma was associated with an increased risk of miscarriage. IUH may be associated with decreased GA and an increased risk of preterm birth. Therefore, Women diagnosed with IUH should be offered increased surveillance during the course of their pregnancy.

我们的荟萃分析旨在估计宫内血肿(IUH)对辅助生殖技术(ART)妊娠的产科和妊娠结局的影响。我们检索了截至 2021 年 12 月的四个电子数据库,以找到报告宫内血肿辅助生殖技术妊娠相关结果的研究。二分法数据以几率比(OR)和 95% 置信区间(CI)表示。连续数据以加权平均差(WMD)和 95% 置信区间(CI)表示。本次荟萃分析共纳入了六项观察性研究。我们的数据表明,通过抗逆转录病毒疗法怀孕的 IUH 孕妇与流产、低出生体重、前置胎盘或胎膜早破的风险增加无关。两组孕妇的出生体重相似。然而,IUH 与明显较短的分娩胎龄(GA)以及较高的早产风险有关。分组分析发现,胎盘后血肿的存在与流产风险增加有关。IUH可能与GA下降和早产风险增加有关。因此,确诊患有 IUH 的妇女在妊娠期间应加强监测。
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引用次数: 0
Higher chromosomal abnormality rate in blastocysts from a subset of patients with pericentric inversion (Inv) 1 variant. 包心倒位(Inv)1 变异患者的囊胚染色体异常率较高。
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-02-20 DOI: 10.1080/14647273.2023.2179896
Miaomiao Jia, Xia Xue

The purpose of this study was to evaluate the incidence of unbalanced chromosome rearrangement in blastocyst-stage embryos from carriers of pericentric inversion of chromosome 1 (PEI-1). A total of 98 embryos from 22 PEI-1 carriers were tested for unbalanced rearrangements, originating from inversion carriers, and overall aneuploidy. Logistic regression analysis indicated that the ratio of inverted segment size to chromosome length was a statistically significant risk factor for unbalanced chromosome rearrangement from PEI-1 carriers (p = 0.003). The optimal cut-off values to predict the risk of unbalanced chromosome rearrangement was 36%, with the incidence being 2.0% in the <36% group and 32.7% in the ≥36% group. The unbalanced embryo rate was 24.4% in male carriers compared to 12.3% in female carriers. Inter-chromosomal effect analysis was performed using 98 blastocysts from PEI-1 carriers and 116 blastocysts from age-matched controls. PEI-1 carriers had similar sporadic aneuploidy rates compared to those of age-matched controls at 32.7 vs. 31.9%, respectively. In conclusion, the risk of unbalanced chromosome rearrangement is affected by inverted segment size in PEI-1 carriers.

本研究的目的是评估 1 号染色体包心反转(PEI-1)携带者囊胚期胚胎中不平衡染色体重排的发生率。对来自 22 个 PEI-1 携带者的 98 个胚胎进行了非平衡重排检测,这些非平衡重排来自倒位携带者和整体非整倍体。逻辑回归分析表明,倒位片段大小与染色体长度的比值是 PEI-1 携带者发生不平衡染色体重排的一个具有统计学意义的风险因素(p = 0.003)。预测染色体不平衡重排风险的最佳临界值为 36%,而 PEI-1 携带者的发生率为 2.0%。
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引用次数: 0
Nuclear sperm integrity and ICSI prognosis in Tunisian patients with MMAF syndrome (multiple morphological abnormalities of the sperm flagella). 突尼斯 MMAF 综合征(精子鞭毛多种形态异常)患者的核精子完整性和 ICSI 预后。
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2023-09-06 DOI: 10.1080/14647273.2023.2251679
Asma Braham, Houda Ghedir, Myriam Beya Ben Khedher, Mounir Ajina, Ali Saad, Samira Ibala-Romdhane

Multiple Morphological Abnormalities of the Sperm Flagella (MMAF) is a severe form of teratozoospermia associated with several sperm flagellar abnormalities. The study included 52 patients with MMAF syndrome and a control group of 25 fertile men. The impact of nuclear sperm quality on intracytoplasmic sperm injection (ICSI) results was studied in 20 couples. TUNEL assay was used to assess sperm DNA fragmentation and aniline-blue staining was used to assess chromatin condensation. To investigate chromosomal meiotic segregation, we used fluorescence in situ hybridization (FISH). Semen morphology analysis revealed a mosaic of multiple flagella morphological abnormalities, including 46.73% short flagella, 16.22% bent flagella, 22.07% coiled flagella, and 10.90% absent flagella, all of which were associated with a high percentage of sperm head abnormalities. The mean DNA fragmentation index was substantially higher in patients compared to controls (p = 0.001), whereas the rate of aniline blue-reacted spermatozoa was not significantly different. There was a significant difference in aneuploidy frequencies between the two groups (p < 0.05). Infertile males with MMAF syndrome had lower sperm nuclear quality, which affected ICSI results. As a result, better sperm selection procedures are being employed to increase the success rate of assisted reproductive technologies (ART).

精子鞭毛多重形态异常(MMAF)是一种严重的畸形精子症,与多种精子鞭毛异常有关。该研究包括 52 名 MMAF 综合征患者和 25 名可育男性组成的对照组。在20对夫妇中研究了核精子质量对卵胞浆内单精子显微注射(ICSI)结果的影响。TUNEL检测法用于评估精子DNA碎片,苯胺蓝染色法用于评估染色质凝集。为了研究染色体减数分裂,我们使用了荧光原位杂交(FISH)技术。精液形态分析表明,精子中存在多种鞭毛形态异常,包括46.73%的短鞭毛、16.22%的弯曲鞭毛、22.07%的卷曲鞭毛和10.90%的无鞭毛,所有这些异常都与精子头部的高比例异常有关。与对照组相比,患者的平均DNA碎片指数要高得多(P = 0.001),而苯胺蓝反应精子的比率却没有显著差异。两组患者的非整倍体频率有明显差异(p
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引用次数: 0
Comprehensive bioinformation analysis of differentially expressed genes in recurrent pregnancy loss. 复发性流产差异表达基因的综合生物信息分析。
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2022-03-21 DOI: 10.1080/14647273.2022.2045636
Huaibin Wang, Zhao Liu, Lijun Meng, Xiujun Zhang

Recurrent pregnancy loss (RPL) occurs frequently, and its causes are complex. The aetiology of nearly 50% of RPL cases is still unknown. This study aimed to ascertain differentially expressed genes (DEGs) and pathways by comprehensive bioinformatics analysis. We downloaded the gene expression microarray of GSE165004 from the Gene Expression Omnibus (GEO). Gene ontology (GO) analysis and Kyoto Encyclopaedia of Gene and Genome (KEGG) pathway enrichment analyses were performed on selected genes by using the R Programming Language. A protein-protein interaction (PPI) network was constructed with the Retrieval of Interacting Genes (STRING). Our analysis revealed that 1,869 genes were differentially expressed in RPL and control groups. GO analysis revealed that the interferon type 1 and the glycoprotein-related biological processes played irreplaceable roles, meanwhile KEGG enrichment analysis also revealed that the cAMP signalling pathway and the prolactin signalling pathway played important roles. In the following study, we found that there were many DEGs in the RPL group that were closely related to endometrial decidualization, such as IL17RD, IL16, SOX4, CREBBP, and POFUT1 as well as Notch1 and RBPJ in the Notch signalling pathway family were down-regulated in the RPL group. The results provided valuable information on the pathogenesis of RPL.

复发性妊娠丢失(RPL)发生频繁,原因复杂。近50% RPL病例的病因尚不清楚。本研究旨在通过综合生物信息学分析确定差异表达基因(DEGs)及其通路。我们从gene expression Omnibus (GEO)下载了GSE165004的基因表达芯片。利用R编程语言对所选基因进行基因本体(GO)分析和京都基因基因组百科全书(KEGG)途径富集分析。利用相互作用基因检索(STRING)技术构建了蛋白质-蛋白质相互作用(PPI)网络。我们的分析显示,在RPL和对照组中有1869个基因存在差异表达。GO分析显示干扰素1型和糖蛋白相关的生物学过程发挥着不可替代的作用,同时KEGG富集分析也显示cAMP信号通路和催乳素信号通路发挥着重要作用。在接下来的研究中,我们发现RPL组中有许多与子宫内膜去脂化密切相关的deg,如IL17RD、IL16、SOX4、CREBBP、POFUT1, Notch信号通路家族中的Notch1、RBPJ在RPL组中下调。结果为RPL的发病机制提供了有价值的信息。
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引用次数: 0
Inequalities in assisted reproduction technology utilisation between the G20 countries. 二十国集团(G20)国家在辅助生殖技术利用方面的不平等。
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2021-12-17 DOI: 10.1080/14647273.2021.2017025
Amir Lass, Geffen Lass

Large global inequalities in assisted reproduction technology (ART) utilisation have existed ever since the introduction of ART. The reasons for these inequalities are multifactorial and include national wealth and affordability, pronatalist policies, regulatory differences in provision, and sociocultural components such as racial, gender and educational inequalities. Examining ART utilisation across the largest world economies (G20 countries) in 2016 (the most recent year with publically available data) reveals significant inequality, which is highly correlated to gross domestic product per capita, a measure of national wealth, and to provision of government funding and/or insurance coverage for in vitro fertilisation and intracytoplasmic sperm injection. A strong negative correlation with the Gender Inequality Index is also noted. The gap in ART utilisation rate will only begin to close once the majority of nations introduce more affordable ART treatment, instigate pronatalist policies, and implement changes in education, attitudes and behaviours to minimise racial and gender inequalities; however, achieving all of these changes may be a very difficult target to attain for many poorer economies, regardless of their size.

自辅助生殖技术(ART)问世以来,全球在辅助生殖技术(ART)利用方面一直存在着巨大的不平等。造成这些不平等现象的原因是多方面的,包括国家财富和经济承受能力、代孕政策、提供服务方面的监管差异以及种族、性别和教育不平等等社会文化因素。对2016年(有公开数据可查的最近一年)世界最大经济体(G20国家)的抗逆转录病毒疗法利用率进行研究后发现,不平等现象非常严重,与衡量国民财富的人均国内生产总值以及政府对体外受精和卵胞浆内单精子注射的资助和/或保险覆盖率高度相关。此外,与性别不平等指数(Gender Inequality Index)也有很强的负相关。只有当大多数国家引入更经济实惠的抗逆转录病毒疗法、推行代孕政策,并在教育、态度和行为方面实施变革,以最大限度地减少种族和性别不平等时,抗逆转录病毒疗法使用率的差距才会开始缩小;然而,对于许多较贫穷的经济体来说,无论其规模大小,实现所有这些变革可能都是一个非常难以达到的目标。
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引用次数: 0
Predictive models for starting dose of gonadotropin in controlled ovarian hyperstimulation: review and progress update. 控制卵巢过度刺激中促性腺激素起始剂量的预测模型:综述和最新进展。
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2023-12-01 Epub Date: 2024-01-24 DOI: 10.1080/14647273.2023.2285937
Xiaoxiao Guo, Hao Zhan, Xianghui Zhang, Yiwei Pang, Huishu Xu, Baolin Zhang, Kaixue Lao, Peihui Ding, Yanlin Wang, Lei Han

Controlled ovarian hyperstimulation (COH) is an essential for in vitro fertilization-embryo transfer (IVF-ET) and an important aspect of assisted reproductive technology (ART). Individual starting doses of gonadotropin (Gn) is a critical decision in the process of COH. It has a crucial impact on the number of retrieved oocytes, the cancelling rate of ART cycles, and complications such as ovarian hyperstimulation syndrome (OHSS), as well as pregnancy outcomes. How to make clinical team more standardized and accurate in determining the starting dose of Gn is an important issue in reproductive medicine. In the past 20 years, research teams worldwide have explored prediction models for Gn starting doses. With the integration of artificial intelligence (AI) and deep learning, it is hoped that there will be more suitable predictive model for Gn starting dose in the future.

控制性卵巢过度刺激(COH)是体外受精-胚胎移植(IVF-ET)的必要条件,也是辅助生殖技术(ART)的一个重要方面。促性腺激素(Gn)的个体起始剂量是COH过程中的关键决定因素。它对获得的卵母细胞数量、ART周期的取消率、卵巢过度刺激综合征(OHSS)等并发症以及妊娠结局都有至关重要的影响。如何使临床团队更加规范和准确地确定Gn起始剂量是生殖医学的一个重要问题。在过去的20年里,世界各地的研究团队探索了Gn起始剂量的预测模型。随着人工智能(AI)与深度学习的融合,希望未来能有更适合Gn起始剂量的预测模型。
{"title":"Predictive models for starting dose of gonadotropin in controlled ovarian hyperstimulation: review and progress update.","authors":"Xiaoxiao Guo, Hao Zhan, Xianghui Zhang, Yiwei Pang, Huishu Xu, Baolin Zhang, Kaixue Lao, Peihui Ding, Yanlin Wang, Lei Han","doi":"10.1080/14647273.2023.2285937","DOIUrl":"10.1080/14647273.2023.2285937","url":null,"abstract":"<p><p>Controlled ovarian hyperstimulation (COH) is an essential for in vitro fertilization-embryo transfer (IVF-ET) and an important aspect of assisted reproductive technology (ART). Individual starting doses of gonadotropin (Gn) is a critical decision in the process of COH. It has a crucial impact on the number of retrieved oocytes, the cancelling rate of ART cycles, and complications such as ovarian hyperstimulation syndrome (OHSS), as well as pregnancy outcomes. How to make clinical team more standardized and accurate in determining the starting dose of Gn is an important issue in reproductive medicine. In the past 20 years, research teams worldwide have explored prediction models for Gn starting doses. With the integration of artificial intelligence (AI) and deep learning, it is hoped that there will be more suitable predictive model for Gn starting dose in the future.</p>","PeriodicalId":13006,"journal":{"name":"Human Fertility","volume":" ","pages":"1609-1616"},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138459595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Human Fertility
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