Pub Date : 2019-01-01DOI: 10.22581/muet1982.1901.17
Sarang Karim, H. H. Memon, Shahzeb Ansari, Kashif Hussain, B. Chowdhry
Modern Telecom Sector is eventually facing exceptionally tough challenges because of continuous and unexpected increase in power density requirement for the communicating machinery and equipment. To fulfil the power requirements for the equipment, a significant architecture and an optimal technique must be introduced. In this paper, a microcontroller-based optimization use of power-density has been carried out. Meeting above requirements, various equipment and electronic devices are employed. We have designed a microcontroller-based system via PROTEUS Virtual System Modeling to acquire efficient and effective results. The main focus of our work is to supply the power to Telecom equipment in meantime. The power is feeding on batteries and DG (Diesel Generator) set, depending on the condition of the power requirements. The changeover operations are performed by different relays, which are dully programmed via a microcontroller in Keil software. The power capacity of Telecom ((Telecommunication) equipment is ranged from 39-48 Volts DC. The rectification process is done by switch mode rectifiers instead of linear rectifiers. Because the switch-mode rectifier technology has brought fabulous improvements in power density as compared to linear rectifiers. This is done via simulation of the smart switch in PROTEUS software. The outcomes of the proposed system are costeffective in terms of fuel consumption of DG.
{"title":"Optimization of Power Plant for Telecom Sector Based on Embedded System","authors":"Sarang Karim, H. H. Memon, Shahzeb Ansari, Kashif Hussain, B. Chowdhry","doi":"10.22581/muet1982.1901.17","DOIUrl":"https://doi.org/10.22581/muet1982.1901.17","url":null,"abstract":"Modern Telecom Sector is eventually facing exceptionally tough challenges because of continuous and unexpected increase in power density requirement for the communicating machinery and equipment. To fulfil the power requirements for the equipment, a significant architecture and an optimal technique must be introduced. In this paper, a microcontroller-based optimization use of power-density has been carried out. Meeting above requirements, various equipment and electronic devices are employed. We have designed a microcontroller-based system via PROTEUS Virtual System Modeling to acquire efficient and effective results. The main focus of our work is to supply the power to Telecom equipment in meantime. The power is feeding on batteries and DG (Diesel Generator) set, depending on the condition of the power requirements. The changeover operations are performed by different relays, which are dully programmed via a microcontroller in Keil software. The power capacity of Telecom ((Telecommunication) equipment is ranged from 39-48 Volts DC. The rectification process is done by switch mode rectifiers instead of linear rectifiers. Because the switch-mode rectifier technology has brought fabulous improvements in power density as compared to linear rectifiers. This is done via simulation of the smart switch in PROTEUS software. The outcomes of the proposed system are costeffective in terms of fuel consumption of DG.","PeriodicalId":13063,"journal":{"name":"Hygeia J. D.Med.10 (1) August 2018 - January 2019","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83447650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.22581/muet1982.1901.01
Fatma Zehra Gogus, G. Tezel
Apneic-event based sleep disorders are very common and affect greatly the daily life of people. However, diagnosis of these disorders by detecting apneic events are very difficult. Studies show that analyzes of airflow signals are effective in diagnosis of apneic-event based sleep disorders. According to these studies, diagnosis can be performed by detecting the apneic episodes of the airflow signals. This work deals with detection of apneic episodes on airflow signals belonging to Apnea-ECG (Electrocardiogram) and MIT (Massachusetts Institute of Technology) BIH (Bastons’s Beth Isreal Hospital) databases. In order to accomplish this task, three representative feature sets namely classic feature set, amplitude feature set and descriptive model feature set were created. The performance of these feature sets were evaluated individually and in combination with the aid of the random forest classifier to detect apneic episodes. Moreover, effective features were selected by OneR Attribute Eval Feature Selection Algorithm to obtain higher performance. Selected 28 features for Apnea-ECG database and 31 features for MITBIH database from 54 features were applied to classifier to compare achievements. As a result, the highest classification accuracies were obtained with the usage of effective features as 96.21% for Apnea-ECG database and 92.23% for MIT-BIH database. Kappa values are also quite good (91.80 and 81.96%) and support the classification accuracies for both databases, too. The results of the study are quite promising for determining apneic events on a minute-by-minute basis.
{"title":"Apneic Events Detection Using Different Features of Airflow Signals","authors":"Fatma Zehra Gogus, G. Tezel","doi":"10.22581/muet1982.1901.01","DOIUrl":"https://doi.org/10.22581/muet1982.1901.01","url":null,"abstract":"Apneic-event based sleep disorders are very common and affect greatly the daily life of people. However, diagnosis of these disorders by detecting apneic events are very difficult. Studies show that analyzes of airflow signals are effective in diagnosis of apneic-event based sleep disorders. According to these studies, diagnosis can be performed by detecting the apneic episodes of the airflow signals. This work deals with detection of apneic episodes on airflow signals belonging to Apnea-ECG (Electrocardiogram) and MIT (Massachusetts Institute of Technology) BIH (Bastons’s Beth Isreal Hospital) databases. In order to accomplish this task, three representative feature sets namely classic feature set, amplitude feature set and descriptive model feature set were created. The performance of these feature sets were evaluated individually and in combination with the aid of the random forest classifier to detect apneic episodes. Moreover, effective features were selected by OneR Attribute Eval Feature Selection Algorithm to obtain higher performance. Selected 28 features for Apnea-ECG database and 31 features for MITBIH database from 54 features were applied to classifier to compare achievements. As a result, the highest classification accuracies were obtained with the usage of effective features as 96.21% for Apnea-ECG database and 92.23% for MIT-BIH database. Kappa values are also quite good (91.80 and 81.96%) and support the classification accuracies for both databases, too. The results of the study are quite promising for determining apneic events on a minute-by-minute basis.","PeriodicalId":13063,"journal":{"name":"Hygeia J. D.Med.10 (1) August 2018 - January 2019","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76678874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-01-01DOI: 10.22581/muet1982.1901.12
Jhaman Das Suthar, I. Rajper, Z. Hassan, N. Depar, V. Suthar
Surface water supplies are gradually becoming short in arid and semi-arid regions of the world. Thus, assessment of groundwater quality for crop use appears to be very essential for management and utilization of precious natural water resources. This study reports the water quality of 52 hand pumps and one tubewell located in the most remote areas of desert region, viz. Islamkot and Mithi talukas of district Tharparkar. The water samples were collected during April 2016 (just before the start of rainy season). The water samples were analyzed for EC (Electrical Conductivity), pH, CO32-, HCO3-, Cl-, Ca2+, Mg2+ and Na+ concentration. The SAR (Sodium Adsorption Ratio) and RSC (Residual Sodium Carbonates) were estimated using their respective formula. The categorization of water samples based on their soluble salt content clearly revealed that the water bodies of majority (65%) of areas were hazardous, while 25% areas were marginal. Thus, only 11% water samples of the area under study had useable irrigation water. Because of SAR and RSC the majority (89 and 77%, respectively) of water samples were found to be free from the sodicity hazard. The study concluded that salinity, and not sodicity was the major threat to the area under irrigation with these water bodies. It is, therefore, suggested that the salinity tolerant crops and their genotypes may be used in this area to sustain crop production.
{"title":"Ground-Water Quality in Islamkot and Mithi Talukas of District Tharparkar, Sindh, Pakistan","authors":"Jhaman Das Suthar, I. Rajper, Z. Hassan, N. Depar, V. Suthar","doi":"10.22581/muet1982.1901.12","DOIUrl":"https://doi.org/10.22581/muet1982.1901.12","url":null,"abstract":"Surface water supplies are gradually becoming short in arid and semi-arid regions of the world. Thus, assessment of groundwater quality for crop use appears to be very essential for management and utilization of precious natural water resources. This study reports the water quality of 52 hand pumps and one tubewell located in the most remote areas of desert region, viz. Islamkot and Mithi talukas of district Tharparkar. The water samples were collected during April 2016 (just before the start of rainy season). The water samples were analyzed for EC (Electrical Conductivity), pH, CO32-, HCO3-, Cl-, Ca2+, Mg2+ and Na+ concentration. The SAR (Sodium Adsorption Ratio) and RSC (Residual Sodium Carbonates) were estimated using their respective formula. The categorization of water samples based on their soluble salt content clearly revealed that the water bodies of majority (65%) of areas were hazardous, while 25% areas were marginal. Thus, only 11% water samples of the area under study had useable irrigation water. Because of SAR and RSC the majority (89 and 77%, respectively) of water samples were found to be free from the sodicity hazard. The study concluded that salinity, and not sodicity was the major threat to the area under irrigation with these water bodies. It is, therefore, suggested that the salinity tolerant crops and their genotypes may be used in this area to sustain crop production.","PeriodicalId":13063,"journal":{"name":"Hygeia J. D.Med.10 (1) August 2018 - January 2019","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75088445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The adsorption behavior of Cu(II) and Cd(II) onto a magnetic lignin-based nanomaterial (MLN) was investigated in detail. The results showed that the adsorption isotherm was better described by the Langmuir model, showing monolayer adsorption with a maximum adsorption capacity of 135.7 and 156.5 mg/g. The kinetics fit the pseudo-second-order model. The thermodynamics showed the enthalpy change of the adsorption for Cu(II) and Cd(II) was 24.12 and 36.49 kJ/mol, with entropy change of 85.12 and 130.3 J/mol·K, respectively; thus, the adsorption was endothermic and spontaneous in the range of 25°C–45°C. Additionally, the adsorbent was easy to regenerate. This study shows that MLN is a capable, sustainable absorbent for the removal of heavy metals.
{"title":"Adsorption performance of magnetic aminated lignin for the removal of Cu(II) and Cd(II)","authors":"Da-feng Zheng, Yingzhi Ma, X. Qiu, Xuejun Pan","doi":"10.32964/TJ18.1.9","DOIUrl":"https://doi.org/10.32964/TJ18.1.9","url":null,"abstract":"The adsorption behavior of Cu(II) and Cd(II) onto a magnetic lignin-based nanomaterial (MLN) was investigated in detail. The results showed that the adsorption isotherm was better described by the Langmuir model, showing monolayer adsorption with a maximum adsorption capacity of 135.7 and 156.5 mg/g. The kinetics fit the pseudo-second-order model. The thermodynamics showed the enthalpy change of the adsorption for Cu(II) and Cd(II) was 24.12 and 36.49 kJ/mol, with entropy change of 85.12 and 130.3 J/mol·K, respectively; thus, the adsorption was endothermic and spontaneous in the range of 25°C–45°C. Additionally, the adsorbent was easy to regenerate. This study shows that MLN is a capable, sustainable absorbent for the removal of heavy metals.","PeriodicalId":13063,"journal":{"name":"Hygeia J. D.Med.10 (1) August 2018 - January 2019","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82516289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yunpu Guo, Bei Liu, Cheng Zou, Daliang Guo, Guo-xin Xue
The antioxidant activity of lignin for producing biochemicals has attracted attention. In this paper, a separation method for lignin is proposed, with high-yield and high-antioxidant activity by using a formic acid-catalyzed subcritical ethanol process. The formic acid-catalyzed ethanol lignin (EOL/FA) and ethanol organosolv lignin (EOL) were first prepared using a high-pressure autoclave at different formic acid dosages. Then, the antioxidant activity and the structural and thermal properties of EOL/FA, EOL, alkali lignin, and sodium lignosulfonate were analyzed using antioxidant analysis, Fourier transform infrared (FTIR) spectroscopy analysis, and thermogravimetric analysis (TGA). The phenolic hydroxyl content of the four lignins was also determined by the Folin–Ciocalteau colorimetric method. Results showed EOL/FA had a higher radical scavenging ability and higher total phenolic hydroxyl content than industrial lignin. It indicated that the formic acid-catalyzed subcritical ethanol process was effective for enhancing the antioxidant activity of lignin.
{"title":"Characterization and evaluation of antioxidation of lignin from bamboo powder using a formic acid-catalyzed ethanol organosolv process","authors":"Yunpu Guo, Bei Liu, Cheng Zou, Daliang Guo, Guo-xin Xue","doi":"10.32964/TJ18.1.59","DOIUrl":"https://doi.org/10.32964/TJ18.1.59","url":null,"abstract":"The antioxidant activity of lignin for producing biochemicals has attracted attention. In this paper, a separation method for lignin is proposed, with high-yield and high-antioxidant activity by using a formic acid-catalyzed subcritical ethanol process. The formic acid-catalyzed ethanol lignin (EOL/FA) and ethanol organosolv lignin (EOL) were first prepared using a high-pressure autoclave at different formic acid dosages. Then, the antioxidant activity and the structural and thermal properties of EOL/FA, EOL, alkali lignin, and sodium lignosulfonate were analyzed using antioxidant analysis, Fourier transform infrared (FTIR) spectroscopy analysis, and thermogravimetric analysis (TGA). The phenolic hydroxyl content of the four lignins was also determined by the Folin–Ciocalteau colorimetric method. Results showed EOL/FA had a higher radical scavenging ability and higher total phenolic hydroxyl content than industrial lignin. It indicated that the formic acid-catalyzed subcritical ethanol process was effective for enhancing the antioxidant activity of lignin.","PeriodicalId":13063,"journal":{"name":"Hygeia J. D.Med.10 (1) August 2018 - January 2019","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78163673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-15DOI: 10.15254/H.J.D.MED.10.2018.177
B. Revanasiddappa, M. Kumar, Hemanth Kumar
Plan: A novel series of pyrazolines were synthesized through chalcones. The synthesized compounds were evaluated for various antioxidant activities. Preface: Pyrazolines belongs to five-membered nitrogen classes of compounds. Pyrazolines were reported with widespread chemotherapeutic activities. Methodology: A new series of Chalcones (2a-j) were prepared by reacting substituted aldehydes and ketones in alcohol medium in presence of NaOH. The chalcones (2a-j) undergoes selective cyclization with benzhydrazide (1) in glacial acetic acid medium to yield the title compounds 1, 3, 5-trisubstituted Pyrazolines (3a-j). The new compounds were assigned on the basis of 1H-NMR, IR and Mass spectral data. The newly synthesized compounds were screened for their In-Vitro antioxidant activity by DPPH, superoxide and nitric oxide methods. Outcome: Some of the tested compounds 3e, 3g, and 3f showed moderate activity when compared to the standard drug ascorbic acid.
{"title":"Synthesis and Antioxidant activity of novel Pyrazoline derivatives","authors":"B. Revanasiddappa, M. Kumar, Hemanth Kumar","doi":"10.15254/H.J.D.MED.10.2018.177","DOIUrl":"https://doi.org/10.15254/H.J.D.MED.10.2018.177","url":null,"abstract":"Plan: A novel series of pyrazolines were synthesized through chalcones. The synthesized compounds were evaluated for various antioxidant activities. \u0000Preface: Pyrazolines belongs to five-membered nitrogen classes of compounds. Pyrazolines were reported with widespread chemotherapeutic activities. \u0000Methodology: A new series of Chalcones (2a-j) were prepared by reacting substituted aldehydes and ketones in alcohol medium in presence of NaOH. The chalcones (2a-j) undergoes selective cyclization with benzhydrazide (1) in glacial acetic acid medium to yield the title compounds 1, 3, 5-trisubstituted Pyrazolines (3a-j). The new compounds were assigned on the basis of 1H-NMR, IR and Mass spectral data. The newly synthesized compounds were screened for their In-Vitro antioxidant activity by DPPH, superoxide and nitric oxide methods. \u0000Outcome: Some of the tested compounds 3e, 3g, and 3f showed moderate activity when compared to the standard drug ascorbic acid.","PeriodicalId":13063,"journal":{"name":"Hygeia J. D.Med.10 (1) August 2018 - January 2019","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85589417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-15DOI: 10.15254/H.J.D.MED.10.2018.173
Nimmy Chacko, C. Shastry, Prerana A Shetty
Plan: The antioxidant activity studies of the extract of Costus igneus leaves Preface: Costus igneus commonly known as fiery costus or Spiral flag is a species of herbaceous plant. It is claimed to help build up insulin in the human body and is sometimes referred to as insulin plant. Insulin plant Costus igneus (Fam: Zingiberaceae) is a tropical evergreen shrub with large, smooth, dark green leaves. The Costus igneus is valued mainly for its tonic, stimulant, and antiseptic properties. It is said to be aphrodisiac and to be able to prevent the hair from turning grey. Its root is anodyne, antibacterial, antispasmodic, aphrodisiac, carminative, stimulant, stomachic, tonic and vermifuge. Methodology: In the present study the antioxidant activity of the leaf extract was studied using four methods viz. DPPH assay, reducing power assay, superoxide radical scavenging assay, and Folin-ciocalteu assay. Outcome: The studies have proved that extract possesses antioxidant activity. In reducing power assay, the plant extract showed 75.43 % increase in reducing power compared to Ascorbic acid which showed 91.94%, at a concentration of 16µg/ml. In DPPH assay, plant extract produced 71.85% DPPH scavenging activity, compared to Ascorbic acid which produced 84.47% at a concentration of 160µg/ml. In superoxide scavenging activity, the plant extract produced 68.19% radical scavenging activity compared to the standard which showed 79.78% at a concentration of 800µg/ml. The IC50 was found to be177 and 367 µg/ ml of the standard and plant extract respectively.
{"title":"Studies on the antioxidant activity of Costus igneus leaf extract","authors":"Nimmy Chacko, C. Shastry, Prerana A Shetty","doi":"10.15254/H.J.D.MED.10.2018.173","DOIUrl":"https://doi.org/10.15254/H.J.D.MED.10.2018.173","url":null,"abstract":"Plan: The antioxidant activity studies of the extract of Costus igneus leaves\u0000Preface: Costus igneus commonly known as fiery costus or Spiral flag is a species of herbaceous plant. It is claimed to help build up insulin in the human body and is sometimes referred to as insulin plant. Insulin plant Costus igneus (Fam: Zingiberaceae) is a tropical evergreen shrub with large, smooth, dark green leaves. The Costus igneus is valued mainly for its tonic, stimulant, and antiseptic properties. It is said to be aphrodisiac and to be able to prevent the hair from turning grey. Its root is anodyne, antibacterial, antispasmodic, aphrodisiac, carminative, stimulant, stomachic, tonic and vermifuge.\u0000Methodology: In the present study the antioxidant activity of the leaf extract was studied using four methods viz. DPPH assay, reducing power assay, superoxide radical scavenging assay, and Folin-ciocalteu assay.\u0000Outcome: The studies have proved that extract possesses antioxidant activity. In reducing power assay, the plant extract showed 75.43 % increase in reducing power compared to Ascorbic acid which showed 91.94%, at a concentration of 16µg/ml. In DPPH assay, plant extract produced 71.85% DPPH scavenging activity, compared to Ascorbic acid which produced 84.47% at a concentration of 160µg/ml. In superoxide scavenging activity, the plant extract produced 68.19% radical scavenging activity compared to the standard which showed 79.78% at a concentration of 800µg/ml. The IC50 was found to be177 and 367 µg/ ml of the standard and plant extract respectively.","PeriodicalId":13063,"journal":{"name":"Hygeia J. D.Med.10 (1) August 2018 - January 2019","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89049168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-15DOI: 10.15254/H.J.D.MED.10.2018.176
M. Revathi, M. Karthikeyan, A. Gnanasekaran, M. Ranjith
Plan: Kukkiladhi choornam is one of the Siddha drugs, which has been indicated for its anti-microbial properties. The aim of the present study was to validate the antibacterial and antifungal activity of Kukkiladhi choornam extract against various microorganisms. Preface: The present study examined the in-vitro screening of antimicrobial activity of Siddha drug Kukkiladhi choornam. Methodology: The extracts were tested for antimicrobial activity using agar well diffusion on solid media. The microorganisms used in the present study include Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli, Salmonella typhi, Shigella flexneri, Proteus vulgaris, and Candida albicans. Outcome: The study revealed that 50µl extract of Kukkiladhichoornam had significant inhibiting activity against Shigellaflexneri (17mm), Streptococcus pyogenes (17mm) and Candida albicans (18mm).
{"title":"Screening of Antimicrobial Activity of Siddha drug Kukkiladhi Choornam","authors":"M. Revathi, M. Karthikeyan, A. Gnanasekaran, M. Ranjith","doi":"10.15254/H.J.D.MED.10.2018.176","DOIUrl":"https://doi.org/10.15254/H.J.D.MED.10.2018.176","url":null,"abstract":"Plan: Kukkiladhi choornam is one of the Siddha drugs, which has been indicated for its anti-microbial properties. The aim of the present study was to validate the antibacterial and antifungal activity of Kukkiladhi choornam extract against various microorganisms.\u0000Preface: The present study examined the in-vitro screening of antimicrobial activity of Siddha drug Kukkiladhi choornam.\u0000Methodology: The extracts were tested for antimicrobial activity using agar well diffusion on solid media. The microorganisms used in the present study include Streptococcus pyogenes, Staphylococcus aureus, Escherichia coli, Salmonella typhi, Shigella flexneri, Proteus vulgaris, and Candida albicans.\u0000Outcome: The study revealed that 50µl extract of Kukkiladhichoornam had significant inhibiting activity against Shigellaflexneri (17mm), Streptococcus pyogenes (17mm) and Candida albicans (18mm).","PeriodicalId":13063,"journal":{"name":"Hygeia J. D.Med.10 (1) August 2018 - January 2019","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83867607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-09-15DOI: 10.15254/H.J.D.MED.10.2018.175
S. T.J, M. Chandran, K. Kumar
Plan: The present research work is aimed to synthesize newer, less toxic and more effective Mannich bases of 1, 4 thiazine derivatives and further compare their antifungal activities. Preface: Microbial infections are becoming the most important issue for global health and economy. Among these fungal infections are the major problem these days. The morbidity and mortality of invasive fungal infections are unacceptably high. It is an urgent need for the development of new antifungal agents to treat these life-threatening invasive infections. Methodology: Mannich base was synthesized by using o-amino thiophenol with maleic anhydride. Further, four derivatives of Mannich bases were synthesized from 3-oxo-3, 4-dihydro-2H-1, 4-benzothiazin-2-yl) acetic acid with sulpha drugs, ethanol, and formaldehyde. Then synthesized Mannich bases were docked against Dihydrofolate reductase complexed with NADPH and 6- methyl-5- [3-methyl-3-(3,4,5-trimethoxyphenyl) but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP115A)using Argus Lab software. On this basis, we selected 3QLS as a biological target for docking study of synthesized compound. Outcome: The structures of the synthesized compounds were confirmed by UV, IR and Mass Spectroscopic studies. All the newly synthesized derivatives were screened for antifungal activity against Candida albicans NCIM 3100 and Aspergillus niger NCIM 596 by agar diffusion method (Kirby- Bauer method) using fluconazole (10µg/disc) as the standard and dimethyl sulphoxide as the vehicle. The docking results indicate the Mannich bases of 1, 4-thiazines (ligand binding energy varies from -8.9046kcal/mol to -12,0457kcal/mol) shows considerable antifungal activity against Candida albicans. Out of the four derivatives, E4 (Sulfamethoxazole substituted 1, 4- thiazine) possess the best ligand pose energy (-12.0414 kcal/mol) and two hydrogen bond. Among these synthesized compounds, compound E4([4({[4-(N-(5-methyl-3-isoxazolyl) amino sulfonyl) phenyl] amino} methyl)-3-oxo-3,4-dihydro-2H1,4-benzothiazin-2yl] acetic acid) showed highest antifungal activity due to the presence of 1,4- thiazine with sulfamethoxazole substitution.
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Pub Date : 2018-09-15DOI: 10.15254/h.j.d.med.10.2018.16
D. Kumar
Trees are known to live for many years. Gautama Buddha attained enlightenment while meditating underneath a peepal tree (Ficus religiosa). A branch of the original tree was rooted in Anuradhapura, Sri Lanka in 288 B.C. and is known as Jaya Sri Maha Bodhi. It is the oldest plant in the world. Long-living plants are found in many parts of the world. The Baobab tree is one among them. Baobab is the common name of a genus of trees (Adansonia) distributed in Madagascar, Africa, Australia and India. The Baobab is the national tree of Madagascar. The Baobab is also known as “bottle tree”, “the tree of life”, “upside-down tree”, and “monkey bread tree”.
众所周知，树可以活很多年。释迦牟尼在菩提树(榕)下冥想时开悟。公元前288年，原始树的一个分支扎根于斯里兰卡的阿努拉德普勒，被称为Jaya Sri Maha Bodhi。它是世界上最古老的植物。世界上许多地方都有长寿的植物。猴面包树就是其中之一。猴面包树(Baobab)是一种分布在马达加斯加、非洲、澳大利亚和印度的树木(Adansonia)的统称。猴面包树是马达加斯加的国树。猴面包树也被称为“瓶树”、“生命之树”、“倒挂树”和“猴面包树”。
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