Pub Date : 1900-01-01DOI: 10.29296/2618723x-2022-01-02
O. Bocharova, R. Karpova, E. Bocharov, A. Aksyonov, V. Kucheryanu
{"title":"Spontaneous tumours growth reducing in cba mice under phytoadaptogen dry extract preventive influence","authors":"O. Bocharova, R. Karpova, E. Bocharov, A. Aksyonov, V. Kucheryanu","doi":"10.29296/2618723x-2022-01-02","DOIUrl":"https://doi.org/10.29296/2618723x-2022-01-02","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129072490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.29296/2618723x-2021-04-06
M. Akimova, D. Akimov, T. Barmina, E.V. Vesnina, S.S. Dobrianskaya
{"title":"Influence of temperature factors on reproduction of laboratory mice and gerbils","authors":"M. Akimova, D. Akimov, T. Barmina, E.V. Vesnina, S.S. Dobrianskaya","doi":"10.29296/2618723x-2021-04-06","DOIUrl":"https://doi.org/10.29296/2618723x-2021-04-06","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133985978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.29296/2618723x-2021-03-07
D. Pozdnyakov, A. Mamleev, K.H. Sarkisyan
{"title":"Changes in the biogenesis of mitochondria in brain tissue in animals under conditions of cerebral ischemia","authors":"D. Pozdnyakov, A. Mamleev, K.H. Sarkisyan","doi":"10.29296/2618723x-2021-03-07","DOIUrl":"https://doi.org/10.29296/2618723x-2021-03-07","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116841526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.29296/2618723x-2021-02-10
A. Kalatanova, V. Nebogatikov, A. Nedorubov, A. Dorotenko
{"title":"Experience with an optimized methodology of safety studies for pediatric medicines using the example of a drug containing cattle cerebral cortex polypeptides","authors":"A. Kalatanova, V. Nebogatikov, A. Nedorubov, A. Dorotenko","doi":"10.29296/2618723x-2021-02-10","DOIUrl":"https://doi.org/10.29296/2618723x-2021-02-10","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132786880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.29296/2618723x-2022-02-01
A. Andreev-Andrievsky, E. A. Lagereva, N. Pankova, M. Mashkin, V. Manskikh, O.Yu. Frolova, O. V. Fadeeva, E. V. Telyatnikova
{"title":"Chronic bladder catheterization, but not the metabolic chambers, is suitable for collection of precise data on murine diuresis","authors":"A. Andreev-Andrievsky, E. A. Lagereva, N. Pankova, M. Mashkin, V. Manskikh, O.Yu. Frolova, O. V. Fadeeva, E. V. Telyatnikova","doi":"10.29296/2618723x-2022-02-01","DOIUrl":"https://doi.org/10.29296/2618723x-2022-02-01","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133464753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.29296/2618723x-2020-03-06
S. Smirnov, A. A. Karpov, A. Gutsalova, I. Kurzina, D. Lytkina, E. Shchepkina, G. A. Plisko, V. Karev, A. Ivkina
Summary. In this study, the biocompatibility of composite materials based on hydroxyapatite and the copolymer lactide and glycolide with different ratios of components was studied on mice: composite material No. 1 – 95: 5 wt%, composite material No. 2 – 93: 7 wt%. During the experiments, 30 outbred male mice weighing 30–40 g were used, which before the operation were randomly divided into six groups depending on what material was implanted into the body: hydroxyapatite, lactide-glycolide copolymer, composite material No. 1, composite material no. 2; in the group of sham-operated animals, access to the pectoralis major muscle was performed without placing the material. Operations were performed to introduce the tested materials for the large pectoral muscle. The experi-ment lasted 22 days. On the 21st day after the operation, blood was collected from the retroorbital sinus to determine the level of white blood cells. After euthanasia in a CO2 box, macroscopic and histological examination of the pectoralis major muscle was performed. Staining of histological preparations was performed using hematoxylin-eosin and van gieson staining on connective tissue. The follow-ing parameters were evaluated: inflammation, fibrosis, and vascularization. It has been shown that isolated use of hydroxyapatite is accompanied by moderate fibrosis and local inflammation. In response to the implantation of a pure copolymer of lactide and glycolide, no reaction was observed on the part of the body. Among composite materials from the point of view of biocompatibility, the optimal material for implantation among the studied was a composite material with a ratio of hydroxyapatite to the copolymer of lactide and glycolide equal to 93:7 wt.% (composite material # 2), the use of which is characterized by a lower degree of inflammation and fibrosis in the implantation zone compared to hydroxyapatite. The greater biocompatibility of composite material No. 2 in comparison with hydroxyapatite and composite material No. 1 can probably be associated with an increase in the content of the copolymer of lactide and glycolide in its composition.
{"title":"Research of the biocompatibility of composite materials based on hydroxyapatitis and copolymer lactide-glycolide on laboratory mice Laboratory","authors":"S. Smirnov, A. A. Karpov, A. Gutsalova, I. Kurzina, D. Lytkina, E. Shchepkina, G. A. Plisko, V. Karev, A. Ivkina","doi":"10.29296/2618723x-2020-03-06","DOIUrl":"https://doi.org/10.29296/2618723x-2020-03-06","url":null,"abstract":"Summary. In this study, the biocompatibility of composite materials based on hydroxyapatite and the copolymer lactide and glycolide with different ratios of components was studied on mice: composite material No. 1 – 95: 5 wt%, composite material No. 2 – 93: 7 wt%. During the experiments, 30 outbred male mice weighing 30–40 g were used, which before the operation were randomly divided into six groups depending on what material was implanted into the body: hydroxyapatite, lactide-glycolide copolymer, composite material No. 1, composite material no. 2; in the group of sham-operated animals, access to the pectoralis major muscle was performed without placing the material. Operations were performed to introduce the tested materials for the large pectoral muscle. The experi-ment lasted 22 days. On the 21st day after the operation, blood was collected from the retroorbital sinus to determine the level of white blood cells. After euthanasia in a CO2 box, macroscopic and histological examination of the pectoralis major muscle was performed. Staining of histological preparations was performed using hematoxylin-eosin and van gieson staining on connective tissue. The follow-ing parameters were evaluated: inflammation, fibrosis, and vascularization. It has been shown that isolated use of hydroxyapatite is accompanied by moderate fibrosis and local inflammation. In response to the implantation of a pure copolymer of lactide and glycolide, no reaction was observed on the part of the body. Among composite materials from the point of view of biocompatibility, the optimal material for implantation among the studied was a composite material with a ratio of hydroxyapatite to the copolymer of lactide and glycolide equal to 93:7 wt.% (composite material # 2), the use of which is characterized by a lower degree of inflammation and fibrosis in the implantation zone compared to hydroxyapatite. The greater biocompatibility of composite material No. 2 in comparison with hydroxyapatite and composite material No. 1 can probably be associated with an increase in the content of the copolymer of lactide and glycolide in its composition.","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122624832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.29296/2618723x-2021-02-03
A. Afanaseva, V. Saparova, T. A. Selmenskikh, I. E. Makarenko
{"title":"Optimal choice method of detection of the viability of cell cultures for tests on proliferation and cytotoxicity","authors":"A. Afanaseva, V. Saparova, T. A. Selmenskikh, I. E. Makarenko","doi":"10.29296/2618723x-2021-02-03","DOIUrl":"https://doi.org/10.29296/2618723x-2021-02-03","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128615690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.57034/2618723x-2022-04-01
D. Bylinskaya, M. Shchipakin, D. Vasiliev
{"title":"Branches of the aortic arch of the rat","authors":"D. Bylinskaya, M. Shchipakin, D. Vasiliev","doi":"10.57034/2618723x-2022-04-01","DOIUrl":"https://doi.org/10.57034/2618723x-2022-04-01","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124905256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.29296/2618723x-2022-02-07
M. Makarova, A. Matichin, A.A. Maticina, V. Makarov
{"title":"Animal choice strategy for research. Report 1: animal choice based on phylogenic relationships","authors":"M. Makarova, A. Matichin, A.A. Maticina, V. Makarov","doi":"10.29296/2618723x-2022-02-07","DOIUrl":"https://doi.org/10.29296/2618723x-2022-02-07","url":null,"abstract":"","PeriodicalId":131225,"journal":{"name":"Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science)","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125233869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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