Pub Date : 2020-04-09DOI: 10.23888/pavlovj20202815-12
Elena A. Galashina, V. Ulyanov, E. V. Gladkova, S. Shpinyak, A. Bondarenko
Aim. To define relations between serum concentrations of sRANKL and BMP-2, IL-1β, TNFα, IL-4 as well as their role in endoprosthesis instability pathogenesis in patients following primary knee arthroplasties. Materials and Methods . 80 patients were retrospectively divided into 2 groups: there were 40 patients with osteolysis and aseptic instabilities of knee endoprosthesises that had developed before 12 months after the surgery in the 1 st group; the 2 nd group was made up of 40 patients with implantat-associated inflammations that had developed in 4 weeks to 12 months after primary knee arthroplasties. 20 volunteer donors made up the control group. The enzyme-linked assay was used to define serum content of sRANKL (pg/ml, Biomedica, Austria), BMP-2 (pg/ml, Ray Bio, USA), cytokines TNFα (pg/ml), IL-1β (pg/ml) and IL-4 (pg/ml) (Vector-Best, CJSC, Novosibirsk, Russian Federation). The comparative analysis of statistically significant indicants was performed defining Spearman rank correlation coefficient . Results . Positive statistically valid relations of average force between concentrations of sRANKL and BMP-2, TNFα, IL-4 were found in patients of the first group in 1 month after surgeries. In 12 months positive relations of the parameters under study subsisted although the relation with IL-4 absented. The emerging of moderate negative statistically significant relations of sRANKL with BMP-2 and TNFα was observed in patients of the 2 nd group in 1 month after surgeries. In 12 months negative relations of average force between sRANKL and BMP-2 subsisted, also new moderate relations emerged: negative relation of BMP-2 with IL-1β as well as positive of sRANKL with IL-1β and TNFα, IL-1β with IL-4. Conclusion . We found that the disorder of metabolic processes in bone tissue surrounding the implantat with the predominance of osteoclastogenesis activating pro-inflammatory cytokines might be the pathogenic factors of endoprosthesis instability development in patients following primary knee arthroplasty.
{"title":"Comparative analysis of the change of bone tissue metabolism condition and cytokine profiles in patients with endoprosthesis instability after primary knee arthroplasty","authors":"Elena A. Galashina, V. Ulyanov, E. V. Gladkova, S. Shpinyak, A. Bondarenko","doi":"10.23888/pavlovj20202815-12","DOIUrl":"https://doi.org/10.23888/pavlovj20202815-12","url":null,"abstract":"Aim. To define relations between serum concentrations of sRANKL and BMP-2, IL-1β, TNFα, IL-4 as well as their role in endoprosthesis instability pathogenesis in patients following primary knee arthroplasties. Materials and Methods . 80 patients were retrospectively divided into 2 groups: there were 40 patients with osteolysis and aseptic instabilities of knee endoprosthesises that had developed before 12 months after the surgery in the 1 st group; the 2 nd group was made up of 40 patients with implantat-associated inflammations that had developed in 4 weeks to 12 months after primary knee arthroplasties. 20 volunteer donors made up the control group. The enzyme-linked assay was used to define serum content of sRANKL (pg/ml, Biomedica, Austria), BMP-2 (pg/ml, Ray Bio, USA), cytokines TNFα (pg/ml), IL-1β (pg/ml) and IL-4 (pg/ml) (Vector-Best, CJSC, Novosibirsk, Russian Federation). The comparative analysis of statistically significant indicants was performed defining Spearman rank correlation coefficient . Results . Positive statistically valid relations of average force between concentrations of sRANKL and BMP-2, TNFα, IL-4 were found in patients of the first group in 1 month after surgeries. In 12 months positive relations of the parameters under study subsisted although the relation with IL-4 absented. The emerging of moderate negative statistically significant relations of sRANKL with BMP-2 and TNFα was observed in patients of the 2 nd group in 1 month after surgeries. In 12 months negative relations of average force between sRANKL and BMP-2 subsisted, also new moderate relations emerged: negative relation of BMP-2 with IL-1β as well as positive of sRANKL with IL-1β and TNFα, IL-1β with IL-4. Conclusion . We found that the disorder of metabolic processes in bone tissue surrounding the implantat with the predominance of osteoclastogenesis activating pro-inflammatory cytokines might be the pathogenic factors of endoprosthesis instability development in patients following primary knee arthroplasty.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"20 1","pages":"5-12"},"PeriodicalIF":0.0,"publicationDate":"2020-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72949455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-09DOI: 10.23888/pavlovj202028188-98
N. D. Sorokina, S. Pertsov, G. V. Selitskiy
In the literature survey, non-pharmaceutical methods of therapy of epilepsy are considered including electrostimulation of vagus nerve, exposure to magnetic field and transcranial magnetic stimulation (TMS). Correlates of the effectiveness of electro- and magnetic stimulation are electrophysiological parameters, clinical data and influence on the mental and cognitive functions. Use of repetitive transcranial magnetic stimulation in addition to antiepileptic drugs has a certain ground. According to modern understanding and the results of experimental studies, the mechanism of modulator inhibitory alterations is associated with a potential of TMS to cause long-term synaptic depression or long-term potentiation. These long-lasting phenomena probably underlie anticonvulsant effects of low frequency magnetic stimulation. Inclusion of physiologists and neurophysiologists into the research will permit to solve such an important problem as a study of physiological mechanisms of the effectiveness of non-pharmacological electro- and magnetic action in epilepsy.
{"title":"Physiological correlates of neuro- and magnetic stimulation in therapy of epilepsy","authors":"N. D. Sorokina, S. Pertsov, G. V. Selitskiy","doi":"10.23888/pavlovj202028188-98","DOIUrl":"https://doi.org/10.23888/pavlovj202028188-98","url":null,"abstract":"In the literature survey, non-pharmaceutical methods of therapy of epilepsy are considered including electrostimulation of vagus nerve, exposure to magnetic field and transcranial magnetic stimulation (TMS). Correlates of the effectiveness of electro- and magnetic stimulation are electrophysiological parameters, clinical data and influence on the mental and cognitive functions. Use of repetitive transcranial magnetic stimulation in addition to antiepileptic drugs has a certain ground. According to modern understanding and the results of experimental studies, the mechanism of modulator inhibitory alterations is associated with a potential of TMS to cause long-term synaptic depression or long-term potentiation. These long-lasting phenomena probably underlie anticonvulsant effects of low frequency magnetic stimulation. Inclusion of physiologists and neurophysiologists into the research will permit to solve such an important problem as a study of physiological mechanisms of the effectiveness of non-pharmacological electro- and magnetic action in epilepsy.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"1 1","pages":"88-98"},"PeriodicalIF":0.0,"publicationDate":"2020-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78214166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-09DOI: 10.23888/pavlovj202028144-56
T. Zykova, L. Vladimirova, O. V. Katelnitskaya, A. Maslov, E. A. Shevyakova, I. Lysenko, N. A. Abramova, A. E. Storozhakova, I. Popova, K. Novoselova, N. Tikhanovskaya, A. Lyanova, L. A. Ryadinskaya, A. V. Tishina, I. Tishchenko, S. N. Kabanov, E. Kalabanova
Aim . To study the prevalence of carriage of polymorphic allele variants of genes of blood coagulation factors in oncological patients. Materials and Methods. 213 Patients with morphologically confirmed oncological diseases were examined. Samples of genomic DNA of peripheral blood of the patients were examined. Using polymerase chain reaction (PCR), polymorphic sites of genes of hemostatic system were studied in real time: F2 (G20210А, rs1799963), F5 (G1691A, rs6025), F7 (G10976A, rs6046), F13 (G226A, rs5985), FGB G(-455)A (rs1800790), ITGA2-α2 (C807T, rs1126643), ITGB3-b (Т1565С, rs5918), PAI-1 4G(-675)5G, rs1799889). Results . The prevalence of carriage of alternative allele of F2 (G20210А) polymorphic locus in the studied group was 1.6%, of F5 (G1691A) – 3.5%, of F7 (G10976A) – 13.4%, of F13 (G226A) – 28.2%, of FGB G(-455)A – 24.9%, of ITGA2-α2 (C807T) – 41.5%, of ITGB3-b (Т1565С) – 15.5%, of PAI-1 4G(-675)5G – 56.6%. A statistically significant increase in the frequency of ‘risk alleles’ of F5 G1691A (р=0.0169), F13 G226A (р=0.0007), FGB G(-455)A (р<0.0001) and ITGA2-α2 C807T (р=0.0201) polymorphic loci was found in oncological patients as compared to the general population. In the same loci, except ITGA2-α2 (C807T), statistically significant differences in the frequency of alternative alleles were found in different localizations of the oncological process. In 92.0% of patients, SNR combination was determined in different components of hemostatic system. Conclusion . Taking into account a high frequency of identification of ‘risk alleles’ in all components of hemostatic system, it is reasonable to carry out additional research to determine the necessity of addition of antiaggregants to antithrombotic therapy in oncological patients.
{"title":"A study of prevalence of polymorphic variants of genes of blood coagulation factors in onco-logical patients","authors":"T. Zykova, L. Vladimirova, O. V. Katelnitskaya, A. Maslov, E. A. Shevyakova, I. Lysenko, N. A. Abramova, A. E. Storozhakova, I. Popova, K. Novoselova, N. Tikhanovskaya, A. Lyanova, L. A. Ryadinskaya, A. V. Tishina, I. Tishchenko, S. N. Kabanov, E. Kalabanova","doi":"10.23888/pavlovj202028144-56","DOIUrl":"https://doi.org/10.23888/pavlovj202028144-56","url":null,"abstract":"Aim . To study the prevalence of carriage of polymorphic allele variants of genes of blood coagulation factors in oncological patients. Materials and Methods. 213 Patients with morphologically confirmed oncological diseases were examined. Samples of genomic DNA of peripheral blood of the patients were examined. Using polymerase chain reaction (PCR), polymorphic sites of genes of hemostatic system were studied in real time: F2 (G20210А, rs1799963), F5 (G1691A, rs6025), F7 (G10976A, rs6046), F13 (G226A, rs5985), FGB G(-455)A (rs1800790), ITGA2-α2 (C807T, rs1126643), ITGB3-b (Т1565С, rs5918), PAI-1 4G(-675)5G, rs1799889). Results . The prevalence of carriage of alternative allele of F2 (G20210А) polymorphic locus in the studied group was 1.6%, of F5 (G1691A) – 3.5%, of F7 (G10976A) – 13.4%, of F13 (G226A) – 28.2%, of FGB G(-455)A – 24.9%, of ITGA2-α2 (C807T) – 41.5%, of ITGB3-b (Т1565С) – 15.5%, of PAI-1 4G(-675)5G – 56.6%. A statistically significant increase in the frequency of ‘risk alleles’ of F5 G1691A (р=0.0169), F13 G226A (р=0.0007), FGB G(-455)A (р<0.0001) and ITGA2-α2 C807T (р=0.0201) polymorphic loci was found in oncological patients as compared to the general population. In the same loci, except ITGA2-α2 (C807T), statistically significant differences in the frequency of alternative alleles were found in different localizations of the oncological process. In 92.0% of patients, SNR combination was determined in different components of hemostatic system. Conclusion . Taking into account a high frequency of identification of ‘risk alleles’ in all components of hemostatic system, it is reasonable to carry out additional research to determine the necessity of addition of antiaggregants to antithrombotic therapy in oncological patients.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"32 1","pages":"44-56"},"PeriodicalIF":0.0,"publicationDate":"2020-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90226467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-09DOI: 10.23888/pavlovj202028173-78
V. P. Gavrilyuk, S. V. Kostin, V. A. Muchkina, D. A. Severinov, N. Kosolapova
Meckel’s diverticulum is a sac-like bulge of the wall of ileum formed in result of incomplete closure of the viteline duct that participates in nutrition of the embryo. Aim . To familiarize a wide community of colleagues with an interesting clinical case of a foreign body (a coin) in Meckel’s diverticulum. In the article, approaches to diagnostics and operative treatment of such patients are given. This clinical observation is of interest to abdominal surgeons from the point of view that Meckel’s diverticulum is most commonly identified by clinical symptoms present in diverticulitis, bleeding or perforating ulcer, in intestinal obstruction caused by formation of a node or of invagination. Conclusion. A situation in which a blunt-ended foreign body permitted to identify Meckel’s diverticulum, is described as casuistically rare.
{"title":"A foreign body (a coin) of Meckel’s diverticulum in a two-year-old child","authors":"V. P. Gavrilyuk, S. V. Kostin, V. A. Muchkina, D. A. Severinov, N. Kosolapova","doi":"10.23888/pavlovj202028173-78","DOIUrl":"https://doi.org/10.23888/pavlovj202028173-78","url":null,"abstract":"Meckel’s diverticulum is a sac-like bulge of the wall of ileum formed in result of incomplete closure of the viteline duct that participates in nutrition of the embryo. Aim . To familiarize a wide community of colleagues with an interesting clinical case of a foreign body (a coin) in Meckel’s diverticulum. In the article, approaches to diagnostics and operative treatment of such patients are given. This clinical observation is of interest to abdominal surgeons from the point of view that Meckel’s diverticulum is most commonly identified by clinical symptoms present in diverticulitis, bleeding or perforating ulcer, in intestinal obstruction caused by formation of a node or of invagination. Conclusion. A situation in which a blunt-ended foreign body permitted to identify Meckel’s diverticulum, is described as casuistically rare.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"4 1","pages":"73-78"},"PeriodicalIF":0.0,"publicationDate":"2020-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89310250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-09DOI: 10.23888/pavlovj202028179-87
R. Kalinin, I. Suchkov, Еmma A. Klimentova, A. Egorov, V. Povarov
Apoptosis is recognized as a programmed cell death controlled by genetic mechanisms and required for normal existence of an organism. Its main task is elimination of defective or mutant cells. The particles of dead cells are engulfed by macrophages with no development of inflammatory reaction. Apoptosis actively participates in embryogenesis, cellular homeostasis, elimination of tumor cells, and may be divided to three phases: signal, effector, and degradation. Its main components are cytoplasmic proteases – caspases. Caspases exist in the cytoplasm in inactive condition – in the form pf procaspases. Being activated, they break down to subunits. Proteins of Bcl-2 family are active participants of the mitochondrial pathway of apoptosis. They influence permeability of the outer membrane of mitochondria. Disorders in the mechanisms of apoptosis underlie many diseases including ischemic lesions, autoimmune disorders, malignant neoplasms. The ability to influence survival or death of cell is known to possess enormous therapeutic potential. At present, active research is under way to study signal pathways that control cell cycle and apoptosis. The article discusses the mechanisms participating in death of vascular endothelium and smooth muscle cells, potential role of apoptosis in atherosclerosis is also described.
{"title":"Apoptosis in vascular pathology: present and future","authors":"R. Kalinin, I. Suchkov, Еmma A. Klimentova, A. Egorov, V. Povarov","doi":"10.23888/pavlovj202028179-87","DOIUrl":"https://doi.org/10.23888/pavlovj202028179-87","url":null,"abstract":"Apoptosis is recognized as a programmed cell death controlled by genetic mechanisms and required for normal existence of an organism. Its main task is elimination of defective or mutant cells. The particles of dead cells are engulfed by macrophages with no development of inflammatory reaction. Apoptosis actively participates in embryogenesis, cellular homeostasis, elimination of tumor cells, and may be divided to three phases: signal, effector, and degradation. Its main components are cytoplasmic proteases – caspases. Caspases exist in the cytoplasm in inactive condition – in the form pf procaspases. Being activated, they break down to subunits. Proteins of Bcl-2 family are active participants of the mitochondrial pathway of apoptosis. They influence permeability of the outer membrane of mitochondria. Disorders in the mechanisms of apoptosis underlie many diseases including ischemic lesions, autoimmune disorders, malignant neoplasms. The ability to influence survival or death of cell is known to possess enormous therapeutic potential. At present, active research is under way to study signal pathways that control cell cycle and apoptosis. The article discusses the mechanisms participating in death of vascular endothelium and smooth muscle cells, potential role of apoptosis in atherosclerosis is also described.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"13 1","pages":"79-87"},"PeriodicalIF":0.0,"publicationDate":"2020-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88460096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-11DOI: 10.23888/pavlovj2019274487-494
I. I. Katelnitskiy, Igor’ I. Katel’nitskiy, E. S. Livadnyaya
Aim. To evaluate and improve the results of reconstructive operations in patients with obliterating atherosclerosis with critical ischemia of the lower limbs through reduction of the rate of thrombotic complications by improvement of diagnosis of risk factors for thrombosis on the basis of coagulogram and Thrombodynamics T-2 test data. Materials and Methods . In the I group of patients (n=48) reconstructive operations were performed on the arteries of lower limbs and anticoagulant therapy with unfractionated heparin (UFH) with control of hemostasiogram before the operation, in 6 hours and 6 days after the operation and with additional control of APTT 30 minutes before introduction of UNH. In the II group (n=34) reconstructive operations were performed with selection of anticoagulant therapy using parameters of hemostasiogram and laboratory-diagnostic system Thrombodynamics Recorder T-2 with control before the operation, in 6 hours, 6 days after the operation and with additional control of APTT in 30 minutes before introduction of UFH. Results. Analysis of the data of coagulogram and Thrombodynamics T-2 test showed statistical significance of APTT, fibrinogen, delay and initial speed of clot growth, a combination of which permits a possibility for correction of heparin therapy for prevention of thrombosis. Conclusions . The dynamics of the parameters of Thrombodynamics T-2 test in selection of UFH dose proves high effectiveness of this method for selection of adequate doses of anticoagulant drugs for prevention of postoperative thromboses in patients with critical ischemia of the lower limbs.
{"title":"Advantages of modern methods of prevention of thrombotic complications in patients with critical ischemia of lower limbs after reconstructive operations","authors":"I. I. Katelnitskiy, Igor’ I. Katel’nitskiy, E. S. Livadnyaya","doi":"10.23888/pavlovj2019274487-494","DOIUrl":"https://doi.org/10.23888/pavlovj2019274487-494","url":null,"abstract":"Aim. To evaluate and improve the results of reconstructive operations in patients with obliterating atherosclerosis with critical ischemia of the lower limbs through reduction of the rate of thrombotic complications by improvement of diagnosis of risk factors for thrombosis on the basis of coagulogram and Thrombodynamics T-2 test data. Materials and Methods . In the I group of patients (n=48) reconstructive operations were performed on the arteries of lower limbs and anticoagulant therapy with unfractionated heparin (UFH) with control of hemostasiogram before the operation, in 6 hours and 6 days after the operation and with additional control of APTT 30 minutes before introduction of UNH. In the II group (n=34) reconstructive operations were performed with selection of anticoagulant therapy using parameters of hemostasiogram and laboratory-diagnostic system Thrombodynamics Recorder T-2 with control before the operation, in 6 hours, 6 days after the operation and with additional control of APTT in 30 minutes before introduction of UFH. Results. Analysis of the data of coagulogram and Thrombodynamics T-2 test showed statistical significance of APTT, fibrinogen, delay and initial speed of clot growth, a combination of which permits a possibility for correction of heparin therapy for prevention of thrombosis. Conclusions . The dynamics of the parameters of Thrombodynamics T-2 test in selection of UFH dose proves high effectiveness of this method for selection of adequate doses of anticoagulant drugs for prevention of postoperative thromboses in patients with critical ischemia of the lower limbs.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"7 5 1","pages":"487-494"},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83405984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-11DOI: 10.23888/pavlovj2019274451-457
A. V. Kosyakov, V. Abrosimov
Aim . To evaluate changes in the cardiointervalogram (CIG) in the test with external peripheral vascular occlusion in patients with chronic obstructive pulmonary disease (COPD) and in individuals without diseases of the respiratory system. Materials and Methods . The study included 105 men, of them 64 patients with COPD (age 64.98±8.67) and 41 volunteers without diseases of the respiratory system (age 61.68±9.21). The autonomic status was examined and alterations in CIG in the test with occlusion were evaluated on Varicard hardware and software complex (OOO Ramena, Russia). Results . The obtained data showed the autonomic imbalance with predomination of the activity of sympathetic division of the autonomic nervous system (ANS) in patients with COPD as compared to the control group (p 0.05). Conclusions. Differences in the results of the test with external peripheral vascular occlusion in patients with COPD and volunteers without diseases of the respiratory system are attributed to hyperactivation of ergofeflex in patents with COPD.
{"title":"Test with external peripheral vascular occlusion in evaluation of ergoreflex in patients with chronic obstructive pulmonary disease","authors":"A. V. Kosyakov, V. Abrosimov","doi":"10.23888/pavlovj2019274451-457","DOIUrl":"https://doi.org/10.23888/pavlovj2019274451-457","url":null,"abstract":"Aim . To evaluate changes in the cardiointervalogram (CIG) in the test with external peripheral vascular occlusion in patients with chronic obstructive pulmonary disease (COPD) and in individuals without diseases of the respiratory system. Materials and Methods . The study included 105 men, of them 64 patients with COPD (age 64.98±8.67) and 41 volunteers without diseases of the respiratory system (age 61.68±9.21). The autonomic status was examined and alterations in CIG in the test with occlusion were evaluated on Varicard hardware and software complex (OOO Ramena, Russia). Results . The obtained data showed the autonomic imbalance with predomination of the activity of sympathetic division of the autonomic nervous system (ANS) in patients with COPD as compared to the control group (p 0.05). Conclusions. Differences in the results of the test with external peripheral vascular occlusion in patients with COPD and volunteers without diseases of the respiratory system are attributed to hyperactivation of ergofeflex in patents with COPD.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"5 1","pages":"451-457"},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84117790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-11DOI: 10.23888/pavlovj2019274475-486
M. Bebchuk
Aim. Integration of information on systemic approach published in literature, and of the own practical experience in rendering psychotherapeutic assistance to children with different forms of phobic anxiety disorders (PAD) aimed at improvement of effectiveness of treatment, of social adaptation of patients with PAD, and at search for organization forms of medical assistance to the given category of children’s population. Materials and Methods. Into the study 61 children of 8-17 years old were involved living at home and admitted to G.E. Sukharevskaya Research and Practical Center of Mental Well-Being of Children and Adolescents in 2018 for different mental disorders including PAD. In the study, analysis of medical histories and protocols of classes with a family psychologist were used. Results. On the basis of the parameters of family functioning three groups of phobic anxiety syndromes were isolated: disorders of the structural aspect (limits, hierarchy, coalitions, triangles), disorders of communication sphere, or of family history. The working systemic hypotheses were illustrated with ten classic examples. Conclusion. Systemic hypotheses of formation of PAD in children permit to construct treatment and rehabilitation strategies directed at improvement of patient’s state through creation of conditions for a prolonged stable remission in the family. Inclusion of classes with a family psychologist/psychotherapist into the plan of treatment and rehabilitation permits to shift the accent of help to a child to the outpatient environment.
{"title":"Systemic approach to сhild psychiatry: insights in etiopathogenesis and organization of assistance","authors":"M. Bebchuk","doi":"10.23888/pavlovj2019274475-486","DOIUrl":"https://doi.org/10.23888/pavlovj2019274475-486","url":null,"abstract":"Aim. Integration of information on systemic approach published in literature, and of the own practical experience in rendering psychotherapeutic assistance to children with different forms of phobic anxiety disorders (PAD) aimed at improvement of effectiveness of treatment, of social adaptation of patients with PAD, and at search for organization forms of medical assistance to the given category of children’s population. Materials and Methods. Into the study 61 children of 8-17 years old were involved living at home and admitted to G.E. Sukharevskaya Research and Practical Center of Mental Well-Being of Children and Adolescents in 2018 for different mental disorders including PAD. In the study, analysis of medical histories and protocols of classes with a family psychologist were used. Results. On the basis of the parameters of family functioning three groups of phobic anxiety syndromes were isolated: disorders of the structural aspect (limits, hierarchy, coalitions, triangles), disorders of communication sphere, or of family history. The working systemic hypotheses were illustrated with ten classic examples. Conclusion. Systemic hypotheses of formation of PAD in children permit to construct treatment and rehabilitation strategies directed at improvement of patient’s state through creation of conditions for a prolonged stable remission in the family. Inclusion of classes with a family psychologist/psychotherapist into the plan of treatment and rehabilitation permits to shift the accent of help to a child to the outpatient environment.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"40 1","pages":"475-486"},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87274939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-11DOI: 10.23888/pavlovj2019274520-529
O. A. Nagibin, E. V. Manukhina, I. Komarov
At present in the Russian Federation (the RF), an organized system of pharmaceutical provision of benefit-entitled citizens is used. With this, statutory regulation is under continuous improvement through adoption of new regulatory acts and amendments to already existing ones [1]. The basis of this process is equal opportunities and rights of all individuals for free provision with medical drugs. Nevertheless, there exist benefit-entitled categories of citizens for whom additional approaches to organization of pharmaceutical provision were adopted. Aim. Analysis of statutory regulation applicable to the existing benefit-entitled citizens. Conclusion . The established normative framework regulating pharmaceutical provision of benefit-entitled citizens both on the federal and regional levels, permits patients to receive the necessary life-saving medicinal therapy. With this, an obligatory condition for receiving such assistance is presence of a certain diagnosis or a certain social status. Far not all patients are included into the list of benefit-entitled citizens. Hence, the existing statutory regulation of healthcare requires further improvement.
{"title":"Statutory regulation of subsidized pharmaceutical provision in Russian Federation","authors":"O. A. Nagibin, E. V. Manukhina, I. Komarov","doi":"10.23888/pavlovj2019274520-529","DOIUrl":"https://doi.org/10.23888/pavlovj2019274520-529","url":null,"abstract":"At present in the Russian Federation (the RF), an organized system of pharmaceutical provision of benefit-entitled citizens is used. With this, statutory regulation is under continuous improvement through adoption of new regulatory acts and amendments to already existing ones [1]. The basis of this process is equal opportunities and rights of all individuals for free provision with medical drugs. Nevertheless, there exist benefit-entitled categories of citizens for whom additional approaches to organization of pharmaceutical provision were adopted. Aim. Analysis of statutory regulation applicable to the existing benefit-entitled citizens. Conclusion . The established normative framework regulating pharmaceutical provision of benefit-entitled citizens both on the federal and regional levels, permits patients to receive the necessary life-saving medicinal therapy. With this, an obligatory condition for receiving such assistance is presence of a certain diagnosis or a certain social status. Far not all patients are included into the list of benefit-entitled citizens. Hence, the existing statutory regulation of healthcare requires further improvement.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"6 1","pages":"520-529"},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91285620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-11DOI: 10.23888/pavlovj2019274530-535
R. Devrishov, V. Kolomin, V. N. Filyaev, I. A. Kudryasheva
In the article materials showing the growing influence of both school and extra-school factors on health of children and adolescents are presented. Special attention is given to the main classes of school-related diseases. Aim. To justify reasonability of studying this problem in Astrakhan within the frames of complex approach to application of health-saving technologies. Conclusion . Problems described in the article are characteristic of practically any region of Russia, in this connection a significant number of studies are carried out in Astrakhan region devoted to issues of protection of children’s health and to investigation of exposure of children to environmental factors. With this, absence of works on evaluation of complex use of health-saving technologies in terms of their influence on health of schoolchildren, permits to consider such hygienic studies actual.
{"title":"Hygienic aspects of influence of environmental factors on formation of schoolchildren’s health","authors":"R. Devrishov, V. Kolomin, V. N. Filyaev, I. A. Kudryasheva","doi":"10.23888/pavlovj2019274530-535","DOIUrl":"https://doi.org/10.23888/pavlovj2019274530-535","url":null,"abstract":"In the article materials showing the growing influence of both school and extra-school factors on health of children and adolescents are presented. Special attention is given to the main classes of school-related diseases. Aim. To justify reasonability of studying this problem in Astrakhan within the frames of complex approach to application of health-saving technologies. Conclusion . Problems described in the article are characteristic of practically any region of Russia, in this connection a significant number of studies are carried out in Astrakhan region devoted to issues of protection of children’s health and to investigation of exposure of children to environmental factors. With this, absence of works on evaluation of complex use of health-saving technologies in terms of their influence on health of schoolchildren, permits to consider such hygienic studies actual.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"23 1","pages":"530-535"},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89726713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：