Pub Date : 2020-01-11DOI: 10.23888/pavlovj2019274468-474
A. Voitovich
Aim. To assess peculiarities of lifestyle of adolescents with health limitations having diffe-rent levels of anxiety. Materials and Methods . In the research 89 adolescents with health limitations were involved studying at an educational institution of secondary professional education. The leading causes of disability (the main disease) were mental and behavioral disorders. Anxiety levels of the adolescents (State Trait Anxiety Inventory), the extent of nicotine addiction (Fagerstrom test) were studied, social factors, duration of night sleep were assessed, organization of leisure was analyzed. Results. Low state anxiety (SA, <30 points) was found in 76.2% of the examined adolescents, moderate SA (33-34 points) – in 23.8%, 51.4% had a high level of trait anxiety (TA). A moderate negative correlation relationship was established between SA and TA of students (r=–0.72, p=0.02). Assessment of the lifestyle of adolescents found the existence of the family disadvantages (each sixth student grew in a social institution); reduction in the night sleep duration (<7 hours) in 30.8% of students; low physical activity (only 18.9% of students attended additional physical culture and sports classes). Nicotine addiction was found in more than 90% of students, 61.2% of students used strong drinks at least once in life. A correlation was established between living in a hostel (r=–0.56, p=0.031), duration of night sleep (r=–0.61, p=0.028), organization of passive rest (r=–0.52, p=0.04) and the level of SA. Conclusion . The conducted research identified the following risk factors for justification of programs for prevention of development of desadaptation: factor of family disadvantages, bad habits, reduced duration of night sleep, low physical activity.
{"title":"Analysis of behavioral risks in adolescents with health limitations and with different anxiety levels","authors":"A. Voitovich","doi":"10.23888/pavlovj2019274468-474","DOIUrl":"https://doi.org/10.23888/pavlovj2019274468-474","url":null,"abstract":"Aim. To assess peculiarities of lifestyle of adolescents with health limitations having diffe-rent levels of anxiety. Materials and Methods . In the research 89 adolescents with health limitations were involved studying at an educational institution of secondary professional education. The leading causes of disability (the main disease) were mental and behavioral disorders. Anxiety levels of the adolescents (State Trait Anxiety Inventory), the extent of nicotine addiction (Fagerstrom test) were studied, social factors, duration of night sleep were assessed, organization of leisure was analyzed. Results. Low state anxiety (SA, <30 points) was found in 76.2% of the examined adolescents, moderate SA (33-34 points) – in 23.8%, 51.4% had a high level of trait anxiety (TA). A moderate negative correlation relationship was established between SA and TA of students (r=–0.72, p=0.02). Assessment of the lifestyle of adolescents found the existence of the family disadvantages (each sixth student grew in a social institution); reduction in the night sleep duration (<7 hours) in 30.8% of students; low physical activity (only 18.9% of students attended additional physical culture and sports classes). Nicotine addiction was found in more than 90% of students, 61.2% of students used strong drinks at least once in life. A correlation was established between living in a hostel (r=–0.56, p=0.031), duration of night sleep (r=–0.61, p=0.028), organization of passive rest (r=–0.52, p=0.04) and the level of SA. Conclusion . The conducted research identified the following risk factors for justification of programs for prevention of development of desadaptation: factor of family disadvantages, bad habits, reduced duration of night sleep, low physical activity.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"112 1","pages":"468-474"},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80649677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-11DOI: 10.23888/pavlovj2019274536-545
N. Chaikina
In the world, a share of elderly and old individuals in the total population is constantly growing. This change in the demographic situation in the modern society certainly arouses a justified interest for the medico-social problems of this category of the population. A special role in this problem is assigned to the medium-grade medical personnel, since a statistically average patient ˃60 years of age suffers from a number of different chronic diseases, including cognitive disorders, senile dementia, syndrome of nutrition deficit, serious disorders in the musculo-skeletal system, etc. Salvation of these and other essential problems requires elaboration of complex targeted programs and special training of the nursing staff for work in hospitals, hospices, palliative beds, etc. In the ‘ageing’ society it is necessary to find appropriate rational forms of organization of medical assistance for aged group of patients and modern ways of interdepartmental interactions that would correspond to the principles of restructure of the healthcare systems. At present in Russia there exist several specialized geriatric and gerontological centers that render different kinds of medical care to the older generation. Integrated character, availability and effectiveness of medico-social assistance for individuals of older age groups is the aim of well-developed geriatric service. Development of such kind of support is also beneficial from the economical point of view in the sense that it permits to reduce duration of repeat stay in hospital, the number of ambulance calls, etc. The mentioned measures will help optimize treatment and diagnosis of age-related diseases and will permit to actualize the term ‘healthy ageing’. In the article, the problems of rendering medical assistance for the older age groups of population are considered with accentuation on the increased role of nursing personnel in realization of medical and social help to the elderly population within the three-level system on an example of the Voronezh region.
{"title":"Modern level of rendering palliative and in patient kinds of geriatric assistance by nursing staff","authors":"N. Chaikina","doi":"10.23888/pavlovj2019274536-545","DOIUrl":"https://doi.org/10.23888/pavlovj2019274536-545","url":null,"abstract":"In the world, a share of elderly and old individuals in the total population is constantly growing. This change in the demographic situation in the modern society certainly arouses a justified interest for the medico-social problems of this category of the population. A special role in this problem is assigned to the medium-grade medical personnel, since a statistically average patient ˃60 years of age suffers from a number of different chronic diseases, including cognitive disorders, senile dementia, syndrome of nutrition deficit, serious disorders in the musculo-skeletal system, etc. Salvation of these and other essential problems requires elaboration of complex targeted programs and special training of the nursing staff for work in hospitals, hospices, palliative beds, etc. In the ‘ageing’ society it is necessary to find appropriate rational forms of organization of medical assistance for aged group of patients and modern ways of interdepartmental interactions that would correspond to the principles of restructure of the healthcare systems. At present in Russia there exist several specialized geriatric and gerontological centers that render different kinds of medical care to the older generation. Integrated character, availability and effectiveness of medico-social assistance for individuals of older age groups is the aim of well-developed geriatric service. Development of such kind of support is also beneficial from the economical point of view in the sense that it permits to reduce duration of repeat stay in hospital, the number of ambulance calls, etc. The mentioned measures will help optimize treatment and diagnosis of age-related diseases and will permit to actualize the term ‘healthy ageing’. In the article, the problems of rendering medical assistance for the older age groups of population are considered with accentuation on the increased role of nursing personnel in realization of medical and social help to the elderly population within the three-level system on an example of the Voronezh region.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"46 1","pages":"536-545"},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89573035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-11DOI: 10.23888/pavlovj2019274503-511
V. A. Lipatov, D. A. Severinov, M. D. Naimzada
Aim. Assessment of different methods of implantation and autopsy of portions of tissue at the sites of insertion of polymer implants. Materials and Methods . Samples of new vessel prostheses (OOO Lintex, Saint Petersburg) were implanted into the subcutaneous layer of the abdominal wall and paravertebral area of 30 rats. Morphological changes at the sites of insertion of implants, and also variation of the values of criteria developed by the authors were evaluated. The results obtained in studies, were evaluated by experts on the basis of the evidence of artefacts in microphotographs, of expected probability for damage to the implant bed in the experiment and in autopsy, of expected technical complexity of getting a sample of the implant and of the periprosthetic capsule in autopsy. Results. The total score of evaluated tissue reactions reached the highest meanings (59) in the group of laboratory animals where the tested samples were implanted into the subcutaneous tissue of the back, which determines this method as least preferable. Variability and error of the method of subcutaneous implantation was higher in the group with implantation of samples into the paravertebral area, since the values of standard deviation (m) in histological examination of this group (from 0.89 to 3.64) exceeded deviations in animals with implantation of the tested prosthetic implants into the abdominal wall (from 0.25 to 2.54). Conclusion. Implantation in the area of the abdominal wall is characterized by lower variability of standard deviation (m) of the morphometric parameters, by lower number of artefacts and by almost complete absence of technical complications in autopsy of the studied material, which, in the opinion of the authors, gives preference to this method in experimental research.
的目标。不同植入方法的评估和聚合物植入部位部分组织的解剖。材料与方法。将新型血管假体(OOO Lintex, Saint Petersburg)样品植入30只大鼠腹壁皮下和椎旁区域。植入物插入部位的形态学变化，以及作者制定的标准值的变化进行了评估。在研究中获得的结果，由专家根据显微照片中的伪影证据，在实验和尸检中对植入物床损坏的预期概率，以及在尸检中获得植入物和假体周围胶囊样本的预期技术复杂性进行评估。结果。在将测试样本植入背部皮下组织的实验动物组中，评估组织反应的总分达到最高(59分)，这决定了该方法是最不可取的。皮下植入方法的变异性和误差在椎旁区植入组中更高，因为该组组织学检查的标准差(m)值(从0.89到3.64)超过了将所测假体植入腹壁动物的偏差(从0.25到2.54)。结论。在腹壁区域植入的特点是形态测量参数的标准偏差(m)变异性较低，人工制品数量较少，并且在研究材料的解剖中几乎完全没有技术并发症，这在作者看来，在实验研究中优先采用这种方法。
{"title":"More on choice of places for insertion of tested samples of polymer implants in study of reaction of tissues of macroorganism","authors":"V. A. Lipatov, D. A. Severinov, M. D. Naimzada","doi":"10.23888/pavlovj2019274503-511","DOIUrl":"https://doi.org/10.23888/pavlovj2019274503-511","url":null,"abstract":"Aim. Assessment of different methods of implantation and autopsy of portions of tissue at the sites of insertion of polymer implants. Materials and Methods . Samples of new vessel prostheses (OOO Lintex, Saint Petersburg) were implanted into the subcutaneous layer of the abdominal wall and paravertebral area of 30 rats. Morphological changes at the sites of insertion of implants, and also variation of the values of criteria developed by the authors were evaluated. The results obtained in studies, were evaluated by experts on the basis of the evidence of artefacts in microphotographs, of expected probability for damage to the implant bed in the experiment and in autopsy, of expected technical complexity of getting a sample of the implant and of the periprosthetic capsule in autopsy. Results. The total score of evaluated tissue reactions reached the highest meanings (59) in the group of laboratory animals where the tested samples were implanted into the subcutaneous tissue of the back, which determines this method as least preferable. Variability and error of the method of subcutaneous implantation was higher in the group with implantation of samples into the paravertebral area, since the values of standard deviation (m) in histological examination of this group (from 0.89 to 3.64) exceeded deviations in animals with implantation of the tested prosthetic implants into the abdominal wall (from 0.25 to 2.54). Conclusion. Implantation in the area of the abdominal wall is characterized by lower variability of standard deviation (m) of the morphometric parameters, by lower number of artefacts and by almost complete absence of technical complications in autopsy of the studied material, which, in the opinion of the authors, gives preference to this method in experimental research.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"65 5 1","pages":"503-511"},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90302324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-11DOI: 10.23888/pavlovj2019274443-450
Y. Smolyakov, B. Kuznik, S. Kalashnikova, N. A. Nolfin, E. Fedorenko, M. M. Mikhahanov
Aim . To study the influence of artificially created stress on hemodynamic parameters of peripheral microcirculation and variability of the heart rhythm in somatically healthy young individuals. Materials and Methods . In the study 30 individuals were involved (of them 16 men) with the mean age 18.2±1.1 years. An artificial stress was created using Stroop method. Assessment of characteristics of hemodynamics of microcirculation (HM) was performed by the method of dynamic scattering of light from erythrocytes. The signal was integrated in the form of three hemodynamic indexes: HI ( Hemodynamic Indexes ). Low frequency index (HI1) was determined by a slow interlayer interaction, high frequency area (HI3) characterized fast shearing of layers. HI2 took intermediate position (precapillary and capillary blood flow). Variability of cardiointervals isolated from pulse component, was assessed by method of variation pulsometry ( Heart Rate Variability, HRV). Results . In the course of study, increase in the heart rate (HR) in the stage of testing was observed that confirms a high extent of stress load. In hemodynamics, redistribution of blood flow was noted toward slow shear velocities (near-wall blood flow). After cessation of stress load, hemodynamic parameters declined and returned to previous values. Parameters characterizing variability of rhythm – LF (sympathetic component), HF (vagal activity), CVI (non-linear parasympathetic index) showed a tendency to growth; here, LF/HF ratio did not change. Conclusion. In result of the carried out study it was possible to formulate a multifactor picture of variation of parameters of microcirculation and of autonomic regulation of cardiac rhythm specific of reactions of adaptation to induced stress. The quantitative criteria of the obtained shears may be integrated into stress indexes to be used in clinical practice. A portable mDLS sensor may be supplemented with specific assessment criteria and used for monitoring of adaptive reactions induced by stressful situations, and for taking early diagnostic and prognostic decisions in the clinical practice, and for self-control of a patient.
{"title":"Adaptation reactions of hemodynamic systems on artificially modulated stress in healthy individuals","authors":"Y. Smolyakov, B. Kuznik, S. Kalashnikova, N. A. Nolfin, E. Fedorenko, M. M. Mikhahanov","doi":"10.23888/pavlovj2019274443-450","DOIUrl":"https://doi.org/10.23888/pavlovj2019274443-450","url":null,"abstract":"Aim . To study the influence of artificially created stress on hemodynamic parameters of peripheral microcirculation and variability of the heart rhythm in somatically healthy young individuals. Materials and Methods . In the study 30 individuals were involved (of them 16 men) with the mean age 18.2±1.1 years. An artificial stress was created using Stroop method. Assessment of characteristics of hemodynamics of microcirculation (HM) was performed by the method of dynamic scattering of light from erythrocytes. The signal was integrated in the form of three hemodynamic indexes: HI ( Hemodynamic Indexes ). Low frequency index (HI1) was determined by a slow interlayer interaction, high frequency area (HI3) characterized fast shearing of layers. HI2 took intermediate position (precapillary and capillary blood flow). Variability of cardiointervals isolated from pulse component, was assessed by method of variation pulsometry ( Heart Rate Variability, HRV). Results . In the course of study, increase in the heart rate (HR) in the stage of testing was observed that confirms a high extent of stress load. In hemodynamics, redistribution of blood flow was noted toward slow shear velocities (near-wall blood flow). After cessation of stress load, hemodynamic parameters declined and returned to previous values. Parameters characterizing variability of rhythm – LF (sympathetic component), HF (vagal activity), CVI (non-linear parasympathetic index) showed a tendency to growth; here, LF/HF ratio did not change. Conclusion. In result of the carried out study it was possible to formulate a multifactor picture of variation of parameters of microcirculation and of autonomic regulation of cardiac rhythm specific of reactions of adaptation to induced stress. The quantitative criteria of the obtained shears may be integrated into stress indexes to be used in clinical practice. A portable mDLS sensor may be supplemented with specific assessment criteria and used for monitoring of adaptive reactions induced by stressful situations, and for taking early diagnostic and prognostic decisions in the clinical practice, and for self-control of a patient.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"35 1","pages":"443-450"},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90619296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-11DOI: 10.23888/pavlovj2019274495-502
A. V. Bocharov
Non-optimal long-term results of endovascular interventions using bare metal stents and their wide use in Russia in acute coronary syndrome (ACS) make it important to study the influence of the mentioned interventions on the results of coronary artery bypass graft surgery (CABG) performed after stenting of the obstructed artery in patients with ACS and multivessel disease. Aim. To study the results of CABG performed at our department in early periods of ACS after stenting of an obstructed artery with bare metal stents versus the results of use of drug coated stents of the 2 nd generation, on the basis of the data of NORSTENT study. Materials and Methods. The work presents the results of a two-year observation of stepwise treatment of 97 patients with ACS and multivessel disease who were performed stenting of an obstructed artery for life-saving indications followed by CABG not later than in 90 days. Patients of the main group had three-vessel disease of coronary arteries with severity of damage 26.0±3.2 points on SYNTAX scale. The time from the moment of stenting to complete revascularization was 64±17 days. Clinico-demographic parameters of the main group were comparable with those of the comparison group (data of NORSTENT study). Results. During observation time two cases of acute myocardial infarction occurred. Repeat revascularization was required in 14 patients (14.4%). The rate of MACCE was 0.1443. Odd ratio (OR) of the risk of MACCE occurrence was 1.61 (95% CI [1.14;2.78]). Conclusion. Surgical revascularization of the coronary bed in early periods after stenting of the obstructed artery with bare metal stents in patients with ACS and multivessel disease has 1.6 times (95% CI 1.14;2.78) higher risk for initiation of adverse cardiovascular events, in comparison with endovascular revascularization with use of drug coated stents of the 2 nd generation.
裸金属支架在俄罗斯急性冠脉综合征(ACS)中的广泛应用，使得研究裸金属支架对ACS合并多血管疾病患者置入阻塞动脉后行冠状动脉旁路移植术(CABG)结果的影响具有重要意义。的目标。以NORSTENT研究数据为基础，研究我科在ACS早期使用裸金属支架置入梗阻动脉后行冠脉搭桥的结果与使用第二代药物涂层支架的结果。材料与方法。这项工作介绍了对97例ACS合并多血管疾病患者进行为期两年的逐步治疗的观察结果，这些患者在不迟于90天内对阻塞的动脉进行支架植入术以挽救生命。主组患者均为冠状动脉三支病变，SYNTAX评分26.0±3.2分。从支架置入到血管重建术的时间为64±17天。主组的临床人口学参数与对照组具有可比性(NORSTENT研究数据)。结果。观察期间发生急性心肌梗死2例。14例(14.4%)患者需要重复血运重建术。MACCE率为0.1443。MACCE发生风险的奇比(OR)为1.61 (95% CI[1.14;2.78])。结论。ACS合并多血管疾病的患者在使用裸金属支架置入阻塞动脉后早期行冠状动脉床外科血运重建术发生不良心血管事件的风险是第2代药物涂层支架血管内血运重建术的1.6倍(95% CI 1.14;2.78)。
{"title":"Long-term results of coronary artery bypass graft surgery after stenting of obstructed artery with bare metal stent in patients with acute coronary syndrome and multivessel disease","authors":"A. V. Bocharov","doi":"10.23888/pavlovj2019274495-502","DOIUrl":"https://doi.org/10.23888/pavlovj2019274495-502","url":null,"abstract":"Non-optimal long-term results of endovascular interventions using bare metal stents and their wide use in Russia in acute coronary syndrome (ACS) make it important to study the influence of the mentioned interventions on the results of coronary artery bypass graft surgery (CABG) performed after stenting of the obstructed artery in patients with ACS and multivessel disease. Aim. To study the results of CABG performed at our department in early periods of ACS after stenting of an obstructed artery with bare metal stents versus the results of use of drug coated stents of the 2 nd generation, on the basis of the data of NORSTENT study. Materials and Methods. The work presents the results of a two-year observation of stepwise treatment of 97 patients with ACS and multivessel disease who were performed stenting of an obstructed artery for life-saving indications followed by CABG not later than in 90 days. Patients of the main group had three-vessel disease of coronary arteries with severity of damage 26.0±3.2 points on SYNTAX scale. The time from the moment of stenting to complete revascularization was 64±17 days. Clinico-demographic parameters of the main group were comparable with those of the comparison group (data of NORSTENT study). Results. During observation time two cases of acute myocardial infarction occurred. Repeat revascularization was required in 14 patients (14.4%). The rate of MACCE was 0.1443. Odd ratio (OR) of the risk of MACCE occurrence was 1.61 (95% CI [1.14;2.78]). Conclusion. Surgical revascularization of the coronary bed in early periods after stenting of the obstructed artery with bare metal stents in patients with ACS and multivessel disease has 1.6 times (95% CI 1.14;2.78) higher risk for initiation of adverse cardiovascular events, in comparison with endovascular revascularization with use of drug coated stents of the 2 nd generation.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"99 1","pages":"495-502"},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76734525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-11DOI: 10.23888/pavlovj2019274512-519
S. Kazakova, E. V. Aftaeva, Elena A. Kurkova
Cardioesophageal carcinoid is a rare neuroendocrine neoplasm. Diagnosis and treatment are especially difficult in case of proximal localization of the gastric lesion (in the region of cardia) which requires a complex multidisciplinary approach. The clinical presentation of gastric carcinoid is in most cases nonspecific, and the tumor is accidentally detected in endoscopic exa-mination for the pain syndrome, dyspepsia, anemia, etc. Thus, all said above makes tumors of cardioesophageal zone a rather actual problem. In this article, on an example of patient K., of 61 years of age, possibilities of a complex approach to diagnosis and treatment of a complicated case of cardioesophageal carcinoid are shown. Conclusion . Diagnosis of carcinoid tumors is difficult and requires a multidisciplinary approach. The algorithm of diagnostic search and treatment tactics should suggest an individual approach in each clinical case which permits to make a correct diagnosis and to successfully reali-ze a required complex of medical measures.
{"title":"Cardioesophageal carcinoid: multidisciplinary approach to diagnosis","authors":"S. Kazakova, E. V. Aftaeva, Elena A. Kurkova","doi":"10.23888/pavlovj2019274512-519","DOIUrl":"https://doi.org/10.23888/pavlovj2019274512-519","url":null,"abstract":"Cardioesophageal carcinoid is a rare neuroendocrine neoplasm. Diagnosis and treatment are especially difficult in case of proximal localization of the gastric lesion (in the region of cardia) which requires a complex multidisciplinary approach. The clinical presentation of gastric carcinoid is in most cases nonspecific, and the tumor is accidentally detected in endoscopic exa-mination for the pain syndrome, dyspepsia, anemia, etc. Thus, all said above makes tumors of cardioesophageal zone a rather actual problem. In this article, on an example of patient K., of 61 years of age, possibilities of a complex approach to diagnosis and treatment of a complicated case of cardioesophageal carcinoid are shown. Conclusion . Diagnosis of carcinoid tumors is difficult and requires a multidisciplinary approach. The algorithm of diagnostic search and treatment tactics should suggest an individual approach in each clinical case which permits to make a correct diagnosis and to successfully reali-ze a required complex of medical measures.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"3 1","pages":"512-519"},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76082053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-11DOI: 10.23888/pavlovj2019274458-467
A. Nizov, E. Suchkova, Aleksej I. Grivenko, L. Nikiforova
Aim. To study possibilities of pharmaceutical correction of clinical laboratory parameters, of endothelial dysfunction and non-specific adaptation reserves in patients with metabolic syndrome (MS) through use of metformin. Materials and Methods. The three-month program involved 53 patients with MS rando-mized to two comparable groups. Patients of the control group were kept on individual low-calorie diet and practiced graduated exercises. Patients of the studied group, besides the mentioned program of modification of the lifestyle, took metformin. In all participants, anthropometric and clinical laboratory parameters were twice evaluated, total body composition, condition of vascular endothelium and non-specific adaptation reserves of an organism were analyzed. The extent of endothelial dysfunction was evaluated by the level of endothelin-1 and by parameters of photoplethysmographic examination, non-specific adaptation reserves – by the method of analysis of the cardiac rhythm variability. Results . Metformin in complex with dietary therapy and physical exercises proved to be a safe medical drug for correction of components of MS and of endothelial dysfunction. Use of metformin in patients with MS in combination with dietary therapy and graduated physical exercises as compared to use of the program of modification of the lifestyle alone, leads to reduction in the body mass, waist circumference (in women) and of the total fat mass. Introduction of metformin into the program of complex therapy of patients with MS, provides more evident correction of the parameters of carbohydrate metabolism, reduction of endothelin-1 and stiffness index of the aortic wall, enhancement of parasympathetic regulation, than modification of the lifestyle alone. Conclusion . Use of metformin in the complex therapy of metabolic syndrome in comparison with the program of modification of the lifestyle, promotes a more significant reduction of the clinical laboratory parameters, of endothelial dysfunction and improves non-specific adaptation reserves of an organism.
{"title":"Possibilities of use of metformin for correction of endothelial dysfunction and adaptation reserves of an organism in patients with metabolic syndrome","authors":"A. Nizov, E. Suchkova, Aleksej I. Grivenko, L. Nikiforova","doi":"10.23888/pavlovj2019274458-467","DOIUrl":"https://doi.org/10.23888/pavlovj2019274458-467","url":null,"abstract":"Aim. To study possibilities of pharmaceutical correction of clinical laboratory parameters, of endothelial dysfunction and non-specific adaptation reserves in patients with metabolic syndrome (MS) through use of metformin. Materials and Methods. The three-month program involved 53 patients with MS rando-mized to two comparable groups. Patients of the control group were kept on individual low-calorie diet and practiced graduated exercises. Patients of the studied group, besides the mentioned program of modification of the lifestyle, took metformin. In all participants, anthropometric and clinical laboratory parameters were twice evaluated, total body composition, condition of vascular endothelium and non-specific adaptation reserves of an organism were analyzed. The extent of endothelial dysfunction was evaluated by the level of endothelin-1 and by parameters of photoplethysmographic examination, non-specific adaptation reserves – by the method of analysis of the cardiac rhythm variability. Results . Metformin in complex with dietary therapy and physical exercises proved to be a safe medical drug for correction of components of MS and of endothelial dysfunction. Use of metformin in patients with MS in combination with dietary therapy and graduated physical exercises as compared to use of the program of modification of the lifestyle alone, leads to reduction in the body mass, waist circumference (in women) and of the total fat mass. Introduction of metformin into the program of complex therapy of patients with MS, provides more evident correction of the parameters of carbohydrate metabolism, reduction of endothelin-1 and stiffness index of the aortic wall, enhancement of parasympathetic regulation, than modification of the lifestyle alone. Conclusion . Use of metformin in the complex therapy of metabolic syndrome in comparison with the program of modification of the lifestyle, promotes a more significant reduction of the clinical laboratory parameters, of endothelial dysfunction and improves non-specific adaptation reserves of an organism.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"32 1","pages":"458-467"},"PeriodicalIF":0.0,"publicationDate":"2020-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75779138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-04-02DOI: 10.23888/PAVLOVJ271117-121-8987
К. Р. Павлова, Российский медико-биологический вестник им. академика И.П. Па Журнала
22 января 2019 г. отечественное медицинское сообщество постигла тяжелая утрата – ушел из жизни Абросимов Владимир Николаевич, доктор медицинских наук, профессор, заведующий кафедрой терапии и семейной медицины ФДПО с курсом медико-социальной экспертизы ФГБОУ ВО РязГМУ Минздрава России, Заслуженный врач РФ, член-корреспондент Евроазиатской Академии медицинских наук, главный внештатный пульмонолог Министерства здравоохранения Рязанской области.
{"title":"Памяти Профессора Абросимова Владимира Николаевича","authors":"К. Р. Павлова, Российский медико-биологический вестник им. академика И.П. Па Журнала","doi":"10.23888/PAVLOVJ271117-121-8987","DOIUrl":"https://doi.org/10.23888/PAVLOVJ271117-121-8987","url":null,"abstract":"22 января 2019 г. отечественное медицинское сообщество постигла тяжелая утрата – ушел из жизни Абросимов Владимир Николаевич, доктор медицинских наук, профессор, заведующий кафедрой терапии и семейной медицины ФДПО с курсом медико-социальной экспертизы ФГБОУ ВО РязГМУ Минздрава России, Заслуженный врач РФ, член-корреспондент Евроазиатской Академии медицинских наук, главный внештатный пульмонолог Министерства здравоохранения Рязанской области.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"19 1","pages":"117-121"},"PeriodicalIF":0.0,"publicationDate":"2019-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81216159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-15DOI: 10.23888/PAVLOVJ2018261106-116
D. S. Pshennikov, Д. С. Пшенников, I. B. Angotoeva, И. Б. Анготоева
The problem of treatment of acute rhinosinusitis (ARS) is extremely important due to high prevalence of the disease. According to statistical data the ARS affects from 6% to 15% of population and does not show any tendency to reduction. These figures are associated with a high rate of acute respiratory viral infection (ARVI) which directly leads to rhinosinusitis. But, however, despite the fact that practically every individual experiences from 2 to 5 episodes of ARVI every year, only 0.5-2% of them are complicated with acute bacterial rhinosinusitis (ABRS). Despite this low percentage of bacterial infection, in 80% of cases systemic antibacterial treatment is prescribed which further worsens the problem of bacterial resistance in the world. The main difficulty in determination of therapeutic approach to ABRS is associated with absence of reliable methods of differential diagnostics of viral and bacterial etiology of the disease. Because of low sensitivity and specificity, none of additional visualization methods of ABRS diagnosing such as radiography, ultrasonography, computed tomography, can be used as a routine laboratory method. Thus, the main method of differential diagnostics of viral and bacterial ARS remains analysis of clinical data which leads to a high rate of diagnostic errors and to polypragmacy. Nowadays there exists a wide range of medications for treatment of ABRS in the pharmacological market. The choice of therapeutic approach by our international colleagues is mostly based on the requirements of evidence-based medicine. Russian scientists, besides evidence-based medicine principles take into account the pathogenesis of the disease. In this article different groups of medications for treatment of ABRS are presented. Some of them do not meet the requirements of evidence-based medicine so far, but they are included to the Russian standards and are used for management of ABRS.
{"title":"Principles of drug therapy for acute bacterial rhinosinusitis: from evidence-based medicine to practice","authors":"D. S. Pshennikov, Д. С. Пшенников, I. B. Angotoeva, И. Б. Анготоева","doi":"10.23888/PAVLOVJ2018261106-116","DOIUrl":"https://doi.org/10.23888/PAVLOVJ2018261106-116","url":null,"abstract":"The problem of treatment of acute rhinosinusitis (ARS) is extremely important due to high prevalence of the disease. According to statistical data the ARS affects from 6% to 15% of population and does not show any tendency to reduction. These figures are associated with a high rate of acute respiratory viral infection (ARVI) which directly leads to rhinosinusitis. But, however, despite the fact that practically every individual experiences from 2 to 5 episodes of ARVI every year, only 0.5-2% of them are complicated with acute bacterial rhinosinusitis (ABRS). Despite this low percentage of bacterial infection, in 80% of cases systemic antibacterial treatment is prescribed which further worsens the problem of bacterial resistance in the world. The main difficulty in determination of therapeutic approach to ABRS is associated with absence of reliable methods of differential diagnostics of viral and bacterial etiology of the disease. Because of low sensitivity and specificity, none of additional visualization methods of ABRS diagnosing such as radiography, ultrasonography, computed tomography, can be used as a routine laboratory method. Thus, the main method of differential diagnostics of viral and bacterial ARS remains analysis of clinical data which leads to a high rate of diagnostic errors and to polypragmacy. Nowadays there exists a wide range of medications for treatment of ABRS in the pharmacological market. The choice of therapeutic approach by our international colleagues is mostly based on the requirements of evidence-based medicine. Russian scientists, besides evidence-based medicine principles take into account the pathogenesis of the disease. In this article different groups of medications for treatment of ABRS are presented. Some of them do not meet the requirements of evidence-based medicine so far, but they are included to the Russian standards and are used for management of ABRS.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"57 1","pages":"106-116"},"PeriodicalIF":0.0,"publicationDate":"2018-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77203854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-03-15DOI: 10.23888/pavlovj201826170-85
V. Ruzhenkova, В В Руженкова, V. Ruzhenkov, В. А. Руженков, A. Bykova, А А Быкова, M. Kolosova, М А Колосова
The importance of this study is justified by the high occurance frequency of this phenomenon amongst young people in the clinical structure of mental disorders and as well as in the framework of psychological defense mechanisms in psychiatrically healthy population. The question of the limits of depersonalization remains unresolved, as there is no single point of view regarding the syndromological affiliation, rendering it ambiguous to evaluate it as a productive or negative disorder. Aim. This study was aimed at verifying the prevalence and clinical structure of depersonalization symptoms amongst young people. Materials and M ethods. A continuous sample consisting of 96 medical students – 68 (71%) female and 28 (29%) male, from 18 to 23 (19±1.2) years was studied using medico-social, clinico-psychopathological, psychometric and statistical methods. Results. Depersonalization symptoms were found amongst 94% of respondents. Different forms of autopsychic depersonalization were identified in the different psyche spheres – effector-volitional sphere, thinking and self-awareness (except the depersonalization in emotional sphere – «pathological insensitivity», which were previously identified). The validity of their separation was confirmed by cluster analysis. Along with depersonalization disorders, in more than half of the cases, a variety of psychosensory disorders were observed. Conclusions. Depersonalization phenomena along with various psychosensory disorders are widespread amongst adolescents without obvious mental disorders or gender preference. Therapy is useful if depersonalization obstructs social functioning and coupled with anxiety and depression.
{"title":"Depersonalization and psychosensory disorders amongst young people who do not seek psychiatric help appeal for psychiatrysts (prevalence, clinical features and classification)","authors":"V. Ruzhenkova, В В Руженкова, V. Ruzhenkov, В. А. Руженков, A. Bykova, А А Быкова, M. Kolosova, М А Колосова","doi":"10.23888/pavlovj201826170-85","DOIUrl":"https://doi.org/10.23888/pavlovj201826170-85","url":null,"abstract":"The importance of this study is justified by the high occurance frequency of this phenomenon amongst young people in the clinical structure of mental disorders and as well as in the framework of psychological defense mechanisms in psychiatrically healthy population. The question of the limits of depersonalization remains unresolved, as there is no single point of view regarding the syndromological affiliation, rendering it ambiguous to evaluate it as a productive or negative disorder. Aim. This study was aimed at verifying the prevalence and clinical structure of depersonalization symptoms amongst young people. Materials and M ethods. A continuous sample consisting of 96 medical students – 68 (71%) female and 28 (29%) male, from 18 to 23 (19±1.2) years was studied using medico-social, clinico-psychopathological, psychometric and statistical methods. Results. Depersonalization symptoms were found amongst 94% of respondents. Different forms of autopsychic depersonalization were identified in the different psyche spheres – effector-volitional sphere, thinking and self-awareness (except the depersonalization in emotional sphere – «pathological insensitivity», which were previously identified). The validity of their separation was confirmed by cluster analysis. Along with depersonalization disorders, in more than half of the cases, a variety of psychosensory disorders were observed. Conclusions. Depersonalization phenomena along with various psychosensory disorders are widespread amongst adolescents without obvious mental disorders or gender preference. Therapy is useful if depersonalization obstructs social functioning and coupled with anxiety and depression.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"28 1","pages":"70-85"},"PeriodicalIF":0.0,"publicationDate":"2018-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87224112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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