Indian Journal of Pharmaceutical Sciences最新文献

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Protective Effect of Sodium Hydrosulfide on Lipopolysaccharide Induced Myocardial Cell Injury Model: Involvement of Oxidative Stress and Endoplasmic Reticulum Stress 氢硫化钠对脂多糖诱导心肌细胞损伤模型的保护作用:氧化应激和内质网应激的参与

IF 0.5 4区医学 Q3 Pharmacology, Toxicology and Pharmaceutics

Indian Journal of Pharmaceutical Sciences

Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.625

Xin Peng, G. Cao, Y. Zeng, Q. Cheng

引用次数: 0

Exploring the Dosage of Asari Radix et Rhizoma in Traditional Chinese Medicine and its Application in Rheumatoid Arthritis 中药细辛的用量及其在类风湿关节炎中的应用探讨

IF 0.5 4区医学 Q3 Pharmacology, Toxicology and Pharmaceutics

Indian Journal of Pharmaceutical Sciences

Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.665

W. Jiang, S. Sun, X. Xin, Linjiang Li

引用次数: 0

In Vitro Antioxidant Assay of Different Phytoconstituents and Extraction Optimization of Phenolics from Cyperus rotundus L 香附不同植物成分体外抗氧化活性测定及酚类物质提取工艺优化

IF 0.5 4区医学 Q3 Pharmacology, Toxicology and Pharmaceutics

Indian Journal of Pharmaceutical Sciences

Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1072

Nidhi Varshney, A. Prakash, D. Singh, Pracheta Janmeda

Varshney et al. : Quantitative Estimation and Antioxidant Activity of Cyperus rotundus Oxidative stress related disorders occur as a result of free radicals in the cellular organs. Antioxidants provide protection contrary to oxidative stress by counteracting free radicals through the help of different bioactive constituents present in the plants. The aim of this study is to find out the quantitative estimation of phytochemicals (phenolics, tannins, flavonoid, non-tannins, alkaloid and saponins), in vitro antioxidant activity (2, 2-diphenyl-1-picryl-hydrazyl-hydrate, metal chelating, ferric reducing, superoxide dismutase and total antioxidant activity) of different parts of Cyperus rotundus . Along with this, the extraction of polyphenolic compounds by conventional and non-conventional methods and their optimization by response surface methodology technique were also studied. As the outcomes of the study, maximum amount of total phenolics content was found in the ethanolic fraction of stem (37.88±0.94 mg gallic acid equivalent/g). The root has shown the highest flavonoid (0.24±0.03 mg QAE/g) and non-tannin content (21.55±2.43 mg gallic acid equivalent/g) in the extract of petroleum ether. The total alkaloids and tannin content in flower and root i.e., 5.05±0.08 mg caffeine equivalent/g and 76.28±0.62 mg tannic acid equivalent/g was found to be better in aqueous extract respectively. The fraction of ethyl acetate has reported the greatest saponin content (39.2±3.8 mg gallic acid equivalent/g). In case of flower part half-maximal inhibitory concentration value of 2, 2-diphenyl-1-picryl-hydrazyl-hydrate and superoxide dismutase antioxidant activity varies from 0.57-1.90 mg/ml and from 0.053-1.401 mg/ml respectively. Antioxidant activity of each part of the plant was reported in the fraction of ethanol and water by fluorescence recovery after photobleaching (0.403±0.009-0.886±0.02 mg/ml), metal chelation activity (0.010±0.0-0.306±0.001 mg/ml) and total antioxidant capacity (0.030±0.0-0.317±0.002 mg/ml). Microwave assisted extraction method was found to be the suitable one for optimization of total phenolic content. So, the relationship between different parameter was determined through response surface methodology technique and evaluated by plotting the graphs. Polar extracts have found to show the maximum quantity of secondary bioactive metabolites and antioxidant activity as compared to non-polar one. And among the comparison between conventional and non-conventional methods, ultra sonication (non-conventional method) has shown the highest yield of bioactive phenolic compound. So, this study shows that Cyperus rotundus has wide range of secondary metabolites showing antioxidant properties that can be applied for different therapeutic applications.

氧化应激相关疾病的发生是细胞器官中自由基的结果。抗氧化剂通过植物中存在的不同生物活性成分的帮助来对抗自由基，从而提供对抗氧化应激的保护。摘要本研究的目的是对香附不同部位的植物化学物质(酚类物质、单宁类物质、黄酮类物质、非单宁类物质、生物碱和皂苷)、体外抗氧化活性(2,2 -二苯基-1-苦味基-水合肼、金属螯合、铁还原、超氧化物歧化酶和总抗氧化活性)进行定量评价。同时，对常规和非常规方法提取多酚类化合物及其响应面法优化进行了研究。结果表明，茎的乙醇部分总酚类物质含量最高(37.88±0.94 mg没食子酸当量/g)。石油醚提取物中黄酮类化合物含量最高(0.24±0.03 mg QAE/g)，非单宁含量最高(21.55±2.43 mg没食子酸当量/g)。花和根的总生物碱和单宁含量分别为5.05±0.08 mg咖啡因当量/g和76.28±0.62 mg单宁酸当量/g。乙酸乙酯的皂苷含量最高(39.2±3.8 mg没食子酸当量/g)。2,2 -二苯基-1-苦味基-水合肼和超氧化物歧化酶抗氧化活性的半最大抑制浓度值分别为0.57 ~ 1.90 mg/ml和0.053 ~ 1.401 mg/ml。光漂白后荧光回收率测定了乙醇和水组分中各部位的抗氧化活性(0.403±0.009 ~ 0.886±0.02 mg/ml)、金属螯合活性(0.010±0.0 ~ 0.306±0.001 mg/ml)和总抗氧化能力(0.030±0.0 ~ 0.317±0.002 mg/ml)。微波辅助提取法是优化总酚含量的最佳方法。因此，通过响应面法技术确定了各参数之间的关系，并通过绘制图形来评价。与非极性提取物相比，极性提取物显示出最大数量的次生生物活性代谢物和抗氧化活性。在常规方法和非常规方法的比较中，超声波(非常规方法)的生物活性酚类化合物收率最高。因此，本研究表明，香草具有广泛的次生代谢物，具有抗氧化特性，可用于不同的治疗应用。

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引用次数: 0

Evaluation of the Drug Utilization Pattern among Pregnant Women in a Tertiary Care Teaching Hospital 某三级教学医院孕妇用药模式评价

IF 0.5 4区医学 Q3 Pharmacology, Toxicology and Pharmaceutics

Indian Journal of Pharmaceutical Sciences

Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1074

E. T., N. S, Pai Mv, Thunga G, Kunhikatta V

A retrospective study was conducted in a tertiary care teaching hospital to evaluate the drug utilization pattern in pregnant women. A total of 876 pregnant women were enrolled in the study. Parameters such as demography, gravidity, comorbid illness, neonatal outcome, drugs prescribed and their utilization details were collected. The mean age of the study population was found to be 29.4±4.4 y (mean±standard deviation). Majority of them underwent caesarean section (68.2 %) compared to normal vaginal delivery (31.8 %). Most of the neonates were healthy (94.3 %) whereas 0.8 % of the neonates expired during the postnatal period. Diabetes mellitus (33.6 %) was the most common comorbidity, followed by hypertension (28.3 %) and thyroid disorders (18.3 %). Folic acid (15.7 %) and calcium (15.2 %) were the most prescribed drugs, followed by ferrous fumarate (7.1 %), vitamin B12 (5.3 %) and vitamin B6 (3.4 %). In terms of defined daily dose/100 bed d, levothyroxine (369.3) was the most frequently utilized drug, followed by digoxin (53.6), dydrogesterone (27.4) and salbutamol (20.5). Estradiol was only the food and drug administration pregnancy category X drug prescribed, as estradiol supplement as this was required to improve pregnancy rates after in vitro fertilization.

对某三级教学医院孕妇用药情况进行回顾性研究。共有876名孕妇参加了这项研究。收集人口统计学、妊娠、合并症、新生儿结局、处方药物及使用情况等参数。研究人群的平均年龄为29.4±4.4 y(平均值±标准差)。与正常阴道分娩(31.8%)相比，其中大多数接受了剖腹产(68.2%)。大多数新生儿是健康的(94.3%)，而0.8%的新生儿在产后死亡。糖尿病(33.6%)是最常见的合并症，其次是高血压(28.3%)和甲状腺疾病(18.3%)。叶酸(15.7%)和钙(15.2%)是最多的处方药，其次是富马酸亚铁(7.1%)、维生素B12(5.3%)和维生素B6(3.4%)。在定义日剂量/100床d方面，左甲状腺素(369.3)是最常用的药物，其次是地高辛(53.6)、地孕酮(27.4)和沙丁胺醇(20.5)。雌二醇只是食品和药物管理局规定的妊娠X类药物，作为雌二醇补充剂，因为这是提高体外受精后妊娠率所必需的。

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引用次数: 0

Evaluation of Changes in Cardiac Function in Chronic Obstructive Pulmonary Disease Treated with Acetylcysteine by Three-Dimensional Ultrasound Spot Tracking Technique 三维超声点跟踪技术评价乙酰半胱氨酸治疗慢性阻塞性肺疾病心功能的变化