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Protective Effect of Sodium Hydrosulfide on Lipopolysaccharide Induced Myocardial Cell Injury Model: Involvement of Oxidative Stress and Endoplasmic Reticulum Stress 氢硫化钠对脂多糖诱导心肌细胞损伤模型的保护作用:氧化应激和内质网应激的参与
IF 0.5 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.625
Xin Peng, G. Cao, Y. Zeng, Q. Cheng
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引用次数: 0
Exploring the Dosage of Asari Radix et Rhizoma in Traditional Chinese Medicine and its Application in Rheumatoid Arthritis 中药细辛的用量及其在类风湿关节炎中的应用探讨
IF 0.5 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.665
W. Jiang, S. Sun, X. Xin, Linjiang Li
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引用次数: 0
In Vitro Antioxidant Assay of Different Phytoconstituents and Extraction Optimization of Phenolics from Cyperus rotundus L 香附不同植物成分体外抗氧化活性测定及酚类物质提取工艺优化
IF 0.5 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1072
Nidhi Varshney, A. Prakash, D. Singh, Pracheta Janmeda
Varshney et al. : Quantitative Estimation and Antioxidant Activity of Cyperus rotundus Oxidative stress related disorders occur as a result of free radicals in the cellular organs. Antioxidants provide protection contrary to oxidative stress by counteracting free radicals through the help of different bioactive constituents present in the plants. The aim of this study is to find out the quantitative estimation of phytochemicals (phenolics, tannins, flavonoid, non-tannins, alkaloid and saponins), in vitro antioxidant activity (2, 2-diphenyl-1-picryl-hydrazyl-hydrate, metal chelating, ferric reducing, superoxide dismutase and total antioxidant activity) of different parts of Cyperus rotundus . Along with this, the extraction of polyphenolic compounds by conventional and non-conventional methods and their optimization by response surface methodology technique were also studied. As the outcomes of the study, maximum amount of total phenolics content was found in the ethanolic fraction of stem (37.88±0.94 mg gallic acid equivalent/g). The root has shown the highest flavonoid (0.24±0.03 mg QAE/g) and non-tannin content (21.55±2.43 mg gallic acid equivalent/g) in the extract of petroleum ether. The total alkaloids and tannin content in flower and root i.e., 5.05±0.08 mg caffeine equivalent/g and 76.28±0.62 mg tannic acid equivalent/g was found to be better in aqueous extract respectively. The fraction of ethyl acetate has reported the greatest saponin content (39.2±3.8 mg gallic acid equivalent/g). In case of flower part half-maximal inhibitory concentration value of 2, 2-diphenyl-1-picryl-hydrazyl-hydrate and superoxide dismutase antioxidant activity varies from 0.57-1.90 mg/ml and from 0.053-1.401 mg/ml respectively. Antioxidant activity of each part of the plant was reported in the fraction of ethanol and water by fluorescence recovery after photobleaching (0.403±0.009-0.886±0.02 mg/ml), metal chelation activity (0.010±0.0-0.306±0.001 mg/ml) and total antioxidant capacity (0.030±0.0-0.317±0.002 mg/ml). Microwave assisted extraction method was found to be the suitable one for optimization of total phenolic content. So, the relationship between different parameter was determined through response surface methodology technique and evaluated by plotting the graphs. Polar extracts have found to show the maximum quantity of secondary bioactive metabolites and antioxidant activity as compared to non-polar one. And among the comparison between conventional and non-conventional methods, ultra sonication (non-conventional method) has shown the highest yield of bioactive phenolic compound. So, this study shows that Cyperus rotundus has wide range of secondary metabolites showing antioxidant properties that can be applied for different therapeutic applications.
氧化应激相关疾病的发生是细胞器官中自由基的结果。抗氧化剂通过植物中存在的不同生物活性成分的帮助来对抗自由基,从而提供对抗氧化应激的保护。摘要本研究的目的是对香附不同部位的植物化学物质(酚类物质、单宁类物质、黄酮类物质、非单宁类物质、生物碱和皂苷)、体外抗氧化活性(2,2 -二苯基-1-苦味基-水合肼、金属螯合、铁还原、超氧化物歧化酶和总抗氧化活性)进行定量评价。同时,对常规和非常规方法提取多酚类化合物及其响应面法优化进行了研究。结果表明,茎的乙醇部分总酚类物质含量最高(37.88±0.94 mg没食子酸当量/g)。石油醚提取物中黄酮类化合物含量最高(0.24±0.03 mg QAE/g),非单宁含量最高(21.55±2.43 mg没食子酸当量/g)。花和根的总生物碱和单宁含量分别为5.05±0.08 mg咖啡因当量/g和76.28±0.62 mg单宁酸当量/g。乙酸乙酯的皂苷含量最高(39.2±3.8 mg没食子酸当量/g)。2,2 -二苯基-1-苦味基-水合肼和超氧化物歧化酶抗氧化活性的半最大抑制浓度值分别为0.57 ~ 1.90 mg/ml和0.053 ~ 1.401 mg/ml。光漂白后荧光回收率测定了乙醇和水组分中各部位的抗氧化活性(0.403±0.009 ~ 0.886±0.02 mg/ml)、金属螯合活性(0.010±0.0 ~ 0.306±0.001 mg/ml)和总抗氧化能力(0.030±0.0 ~ 0.317±0.002 mg/ml)。微波辅助提取法是优化总酚含量的最佳方法。因此,通过响应面法技术确定了各参数之间的关系,并通过绘制图形来评价。与非极性提取物相比,极性提取物显示出最大数量的次生生物活性代谢物和抗氧化活性。在常规方法和非常规方法的比较中,超声波(非常规方法)的生物活性酚类化合物收率最高。因此,本研究表明,香草具有广泛的次生代谢物,具有抗氧化特性,可用于不同的治疗应用。
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引用次数: 0
Evaluation of the Drug Utilization Pattern among Pregnant Women in a Tertiary Care Teaching Hospital 某三级教学医院孕妇用药模式评价
IF 0.5 4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1074
E. T., N. S, Pai Mv, Thunga G, Kunhikatta V
A retrospective study was conducted in a tertiary care teaching hospital to evaluate the drug utilization pattern in pregnant women. A total of 876 pregnant women were enrolled in the study. Parameters such as demography, gravidity, comorbid illness, neonatal outcome, drugs prescribed and their utilization details were collected. The mean age of the study population was found to be 29.4±4.4 y (mean±standard deviation). Majority of them underwent caesarean section (68.2 %) compared to normal vaginal delivery (31.8 %). Most of the neonates were healthy (94.3 %) whereas 0.8 % of the neonates expired during the postnatal period. Diabetes mellitus (33.6 %) was the most common comorbidity, followed by hypertension (28.3 %) and thyroid disorders (18.3 %). Folic acid (15.7 %) and calcium (15.2 %) were the most prescribed drugs, followed by ferrous fumarate (7.1 %), vitamin B12 (5.3 %) and vitamin B6 (3.4 %). In terms of defined daily dose/100 bed d, levothyroxine (369.3) was the most frequently utilized drug, followed by digoxin (53.6), dydrogesterone (27.4) and salbutamol (20.5). Estradiol was only the food and drug administration pregnancy category X drug prescribed, as estradiol supplement as this was required to improve pregnancy rates after in vitro fertilization.
对某三级教学医院孕妇用药情况进行回顾性研究。共有876名孕妇参加了这项研究。收集人口统计学、妊娠、合并症、新生儿结局、处方药物及使用情况等参数。研究人群的平均年龄为29.4±4.4 y(平均值±标准差)。与正常阴道分娩(31.8%)相比,其中大多数接受了剖腹产(68.2%)。大多数新生儿是健康的(94.3%),而0.8%的新生儿在产后死亡。糖尿病(33.6%)是最常见的合并症,其次是高血压(28.3%)和甲状腺疾病(18.3%)。叶酸(15.7%)和钙(15.2%)是最多的处方药,其次是富马酸亚铁(7.1%)、维生素B12(5.3%)和维生素B6(3.4%)。在定义日剂量/100床d方面,左甲状腺素(369.3)是最常用的药物,其次是地高辛(53.6)、地孕酮(27.4)和沙丁胺醇(20.5)。雌二醇只是食品和药物管理局规定的妊娠X类药物,作为雌二醇补充剂,因为这是提高体外受精后妊娠率所必需的。
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引用次数: 0
A Pilot Study on Assessment of Impact of Pharmacist-Delivered Intervention on Compliance and Low-Density Lipoprotein Goals Among Patients with Cardiovascular Disease 评估药师干预对心血管疾病患者依从性和低密度脂蛋白目标影响的初步研究
4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1180
V. Nallasamy, P. M. Deepa, M. Sudha, S. Ramanathan
The objective of this work was to assess the pharmacist provided telephonic patient educational interventions, designed to improve the management of lipid levels and reduce the non-compliance of lipid-lowering medications. This work was a prospective study. The participants were 60 adults (intervention group with 30 and control group with 30) with cardiovascular disease prescribed lipid-lowering drugs to manage dyslipidemia. Patients in the intervention group were advised regarding lipid management and compliance with therapy by a pharmacist through regular face-to-face counseling and telephonic counseling. Control group patients were received standard medical care. The primary outcome measure was the percentage of patients who achieved a goal low-density lipoprotein below 100 mg/dl±5 % and improvement in adherence to the prescribed medications after 2 mo. In the intervention group, a significant difference was observed in the low-density lipoprotein levels and improvement in adherence after 2 mo of pharmacist intervention. The study demonstrated that pharmacists’ individualized telephonic counseling had positive impacts on the management of lipid levels, including improved medication compliance.
这项工作的目的是评估药剂师提供的电话病人教育干预,旨在改善血脂水平的管理和减少不遵守降脂药物。这项工作是一项前瞻性研究。参与者是60名患有心血管疾病的成年人(干预组30人,对照组30人),他们服用了降脂药物来控制血脂异常。干预组患者由药剂师通过定期的面对面咨询和电话咨询告知血脂管理和治疗依从性。对照组患者接受标准医疗护理。主要结局指标是达到低密度脂蛋白低于100 mg/dl±5%目标的患者百分比,以及2个月后对处方药依从性的改善。在干预组中,在药剂师干预2个月后,观察到低密度脂蛋白水平和依从性的改善有显著差异。研究表明,药师个性化电话咨询对血脂水平管理有积极影响,包括提高服药依从性。
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引用次数: 0
A Scoping Review of Oral Chinese Traditional Medicine for Vascular Dementia 中药口服治疗血管性痴呆的综述
4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1153
X. Yu, Li Ran, Y. Guan, Chenyu Li, J. Shu, Wenqiang Tao, Xiujuan Mi, Xiaoqiong Luo, Z. Lian, Yuhua Zhao, Xing Liao, Jian Yang, Xin Xiong, Xiaoli Qu, Xiaofei Gao, Jun Tang
Vascular dementia is a serious neurological disease associated with reduced perfusion of the brain. No western drugs have been approved for the treatment of vascular dementia. Oral Chinese drugs are commonly employed for vascular dementia in China. The purpose of this scope review is to review the recent evidence from clinical trials regarding the benefits of traditional oral Chinese medicines and to outline their effects on vascular dementia. Seventeen Chinese herbal medicines used in vascular dementia were systematically searched from 7 databases, such as EMBASE, Cochrane, PubMed, China Sci-Tech journal database, China National Knowledge Infrastructure, Chinese Biomedical Database as well as Wanfang database. Data were obtained from guidelines, consensus, meta-analyses and systematic reviews and randomized controlled trials. A revised Cochrane Risk Assessment Instrument was applied to evaluate the risk of bias with respect to the intention-to-treat effect on eligible randomized controlled trials. Microsoft Excel 2019, GraphPad Prism and RSTUDIO statistics were employed for data integration and process. As the data show, the number of research published increased between 2009 and 2014, while the most studied medicines were TianZhi, Ginkgo biloba leaf and NaoXinTong. A low overall bias risk of intention-to-treat was achieved in only 7 trials. More consistent benefits were observed with Ginkgo biloba leaf and TianZhi for amelioration of mini-mental state examination score deficits and activities of daily living impairments. The overall reporting quality of randomized controlled trials of traditional oral Chinese medicines for vascular dementia was poor and the transparency of these randomized controlled trials must be urgently improved. Oral Chinese drugs may be beneficial to patients with vascular dementia, but they need to be further assessed.
血管性痴呆是一种与脑灌注减少有关的严重神经系统疾病。目前还没有西药被批准用于治疗血管性痴呆。在中国,口服中药是治疗血管性痴呆的常用药物。本综述的目的是回顾近期临床试验中有关中药口服益处的证据,并概述其对血管性痴呆的影响。系统检索EMBASE、Cochrane、PubMed、中国科技期刊库、中国国家知识基础设施、中国生物医学数据库、万方数据库等7个数据库中治疗血管性痴呆的17种中草药。数据来自指南、共识、荟萃分析、系统评价和随机对照试验。采用修订后的Cochrane风险评估工具对符合条件的随机对照试验的意向治疗效应进行偏倚风险评估。采用Microsoft Excel 2019、GraphPad Prism和RSTUDIO统计进行数据整合和处理。数据显示,2009年至2014年间,发表的研究数量有所增加,而研究最多的药物是天栀、银杏叶和脑心通。意向治疗的总体偏倚风险较低,仅在7项试验中实现。银杏叶和天栀在改善轻度精神状态考试分数缺陷和日常生活活动障碍方面的效果更为一致。中药口服治疗血管性痴呆的随机对照试验总体报告质量较差,其透明度亟待提高。口服中药可能对血管性痴呆患者有益,但需要进一步评估。
{"title":"A Scoping Review of Oral Chinese Traditional Medicine for Vascular Dementia","authors":"X. Yu, Li Ran, Y. Guan, Chenyu Li, J. Shu, Wenqiang Tao, Xiujuan Mi, Xiaoqiong Luo, Z. Lian, Yuhua Zhao, Xing Liao, Jian Yang, Xin Xiong, Xiaoli Qu, Xiaofei Gao, Jun Tang","doi":"10.36468/pharmaceutical-sciences.1153","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1153","url":null,"abstract":"Vascular dementia is a serious neurological disease associated with reduced perfusion of the brain. No western drugs have been approved for the treatment of vascular dementia. Oral Chinese drugs are commonly employed for vascular dementia in China. The purpose of this scope review is to review the recent evidence from clinical trials regarding the benefits of traditional oral Chinese medicines and to outline their effects on vascular dementia. Seventeen Chinese herbal medicines used in vascular dementia were systematically searched from 7 databases, such as EMBASE, Cochrane, PubMed, China Sci-Tech journal database, China National Knowledge Infrastructure, Chinese Biomedical Database as well as Wanfang database. Data were obtained from guidelines, consensus, meta-analyses and systematic reviews and randomized controlled trials. A revised Cochrane Risk Assessment Instrument was applied to evaluate the risk of bias with respect to the intention-to-treat effect on eligible randomized controlled trials. Microsoft Excel 2019, GraphPad Prism and RSTUDIO statistics were employed for data integration and process. As the data show, the number of research published increased between 2009 and 2014, while the most studied medicines were TianZhi, Ginkgo biloba leaf and NaoXinTong. A low overall bias risk of intention-to-treat was achieved in only 7 trials. More consistent benefits were observed with Ginkgo biloba leaf and TianZhi for amelioration of mini-mental state examination score deficits and activities of daily living impairments. The overall reporting quality of randomized controlled trials of traditional oral Chinese medicines for vascular dementia was poor and the transparency of these randomized controlled trials must be urgently improved. Oral Chinese drugs may be beneficial to patients with vascular dementia, but they need to be further assessed.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Changes in Cardiac Function in Chronic Obstructive Pulmonary Disease Treated with Acetylcysteine by Three-Dimensional Ultrasound Spot Tracking Technique 三维超声点跟踪技术评价乙酰半胱氨酸治疗慢性阻塞性肺疾病心功能的变化
4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.714
Xin Wang, T. Fan, Y. Hou, Aixiang Liu
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引用次数: 0
Meta-Analysis of Ketorolac Tromethamine on Postoperative Analgesia for Colorectal Cancer 酮咯酸Tromethamine用于结直肠癌术后镇痛的meta分析
4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.723
G. Ji, Huanhuan Zhang, Xiulan Liu, Y. Zhang
{"title":"Meta-Analysis of Ketorolac Tromethamine on Postoperative Analgesia for Colorectal Cancer","authors":"G. Ji, Huanhuan Zhang, Xiulan Liu, Y. Zhang","doi":"10.36468/pharmaceutical-sciences.spl.723","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.723","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Puerarin’s Mechanism in Treating Diabetic Osteoporosis by using Network Pharmacology 葛根素治疗糖尿病骨质疏松的网络药理学机制分析
4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.696
Yuwei Chen, Qiyuan Sun
Puerarin can promote the proliferation of osteoblasts and it can also be used as a scaffold material, but its mechanism is unknown. In this study, we explored the primary molecular mechanism of puerarin in diabetic osteoporosis treatment. We used traditional Chinese medicine systems pharmacology database and analysis platform, PubChem, web-based gene set analysis toolkit, cytoscape and so on to screen the drug targets of puerarin and the disease targets of diabetic osteoporosis. We analyzed the puerarin mechanism based on the protein-protein interaction co-expression network, gene ontology, Kyoto encyclopedia of genes and genomes enrichment, etc., and molecular docking by AutoDock. The main enriched signaling pathways in the Kyoto encyclopedia of genes and genomes were non-small cell lung cancer, endocrine resistance and so on. The main enriched biological processes were positive regulation of cell migration, cytokine-mediated signaling pathway and so on. The main enriched cell components of the cellular component were the integrin complex, platelet alpha granule membrane and so on. The main cellular functions of the molecular function were C-X3-C chemokine binding, nitric oxide synthase regulator activity and so on. The tumor necrosis factor, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha and prostaglandin-endoperoxide synthase 2 with puerarin docking binding energy were all less than -5 kcal/mol-1. In conclusion puerarin may act through multiple targets and some pathways in diabetic osteoporosis.
葛根素可促进成骨细胞增殖,也可作为支架材料,但其作用机制尚不清楚。在本研究中,我们探讨了葛根素治疗糖尿病骨质疏松症的主要分子机制。我们利用中药系统药理学数据库和分析平台、PubChem、基于web的基因集分析工具包、cytoscape等筛选葛根素的药物靶点和糖尿病骨质疏松症的疾病靶点。基于蛋白-蛋白互作共表达网络、基因本体、京都基因与基因组富集百科全书等,通过AutoDock进行分子对接,分析葛根素的作用机制。《京都基因基因组百科全书》中富集的主要信号通路为非小细胞肺癌、内分泌抵抗等。主要富集的生物过程有细胞迁移的正向调节、细胞因子介导的信号通路等。细胞成分中主要富集的细胞成分为整合素复合物、血小板α颗粒膜等。分子功能的主要细胞功能有C-X3-C趋化因子结合、一氧化氮合酶调节活性等。肿瘤坏死因子、磷脂酰肌醇-4,5-二磷酸3-激酶催化亚基α和前列腺素内过氧化物合成酶2与葛根素对接结合能均小于-5 kcal/mol-1。综上所述,葛根素在糖尿病性骨质疏松中可能通过多靶点、多途径起作用。
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引用次数: 0
Effects of Interventions Combined with Drugs on Serum 5-Hydroxytryptamine and Gamma-Aminobutyric Acid Levels in Neurological Tinnitus 干预联合药物对神经性耳鸣患者血清5-羟色胺和γ -氨基丁酸水平的影响
4区 医学 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.720
Wusiman Zumureti, Ting Zhao
{"title":"Effects of Interventions Combined with Drugs on Serum 5-Hydroxytryptamine and Gamma-Aminobutyric Acid Levels in Neurological Tinnitus","authors":"Wusiman Zumureti, Ting Zhao","doi":"10.36468/pharmaceutical-sciences.spl.720","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.720","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Indian Journal of Pharmaceutical Sciences
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