Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.1163
Yanan Liu, Lin Yang, Y. Gu, L. Guo, Qi Guo
{"title":"Walnut Green Husk Extract Suppresses Ovarian Cancer Cell Proliferation Migration and Invasion via Modulating microRNA-144-3p","authors":"Yanan Liu, Lin Yang, Y. Gu, L. Guo, Qi Guo","doi":"10.36468/pharmaceutical-sciences.1163","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1163","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135402038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.spl.732
S. L. Zhang, W. Chen, Y. Z. Ge, C. C. Zhou, R. P. Jia
Our main objective is to study the effect of diuretic Paishi mixture on renal calculus after extracorporeal shock wave lithotripsy and its effect on renal function and urinary N-acetyl-beta-d-glucosaminidase, beta-2 microglobulin, cystatin C levels. A total of 150 patients with kidney stones undergoing extracorporeal shock wave surgery were randomly divided into research group and control group with 75 subjects in each group. The patients in the control group were treated with routine methods such as anti-infection, pain relief and hemostasis after operation, while the research group was treated with diuretic and stone-dispelling mixture on the basis of the control group. The medication cycle is 7 d. The treatment effects, symptom scores, average time for residual stone removal, renal function-related indicators, urine N-acetyl-beta-d-glucosaminidase, beta-2 microglobulin, cystatin C levels, inflammatory factor levels and the proportion of analgesic drugs were compared between the two groups. The drug effect of the study group was better than that of the control group (p<0.05), the symptom score, average time of residual stone excretion, levels of renal function indicators, blood creatinine and blood urea nitrogen in the study group were lower than those of the control group (p<0.05). The levels of urinary N-acetyl-beta-d-glucosaminidase, beta-2 microglobulin and cystatin C in the study group were better than those in the control group (p<0.05). The indicators of inflammatory factors and usage rate of analgesic drugs in the study group were lower than those in the control group (p<0.05). Diuretic and stone removal mixture can significantly improve the postoperative effect of extracorporeal shock wave lithotripsy, shorten the time of stone removal, increase the levels of renal function, urinary N-acetyl-beta-dglucosaminidase, beta-2 microglobulin, cystatin C, etc., improve the level of inflammatory factors and reduce the usage rate of analgesic drugs.
{"title":"Effect of Diuretic and Stone Removal Mixture on Kidney Stones and its Influence on Renal Function and Urinary Levels","authors":"S. L. Zhang, W. Chen, Y. Z. Ge, C. C. Zhou, R. P. Jia","doi":"10.36468/pharmaceutical-sciences.spl.732","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.732","url":null,"abstract":"Our main objective is to study the effect of diuretic Paishi mixture on renal calculus after extracorporeal shock wave lithotripsy and its effect on renal function and urinary N-acetyl-beta-d-glucosaminidase, beta-2 microglobulin, cystatin C levels. A total of 150 patients with kidney stones undergoing extracorporeal shock wave surgery were randomly divided into research group and control group with 75 subjects in each group. The patients in the control group were treated with routine methods such as anti-infection, pain relief and hemostasis after operation, while the research group was treated with diuretic and stone-dispelling mixture on the basis of the control group. The medication cycle is 7 d. The treatment effects, symptom scores, average time for residual stone removal, renal function-related indicators, urine N-acetyl-beta-d-glucosaminidase, beta-2 microglobulin, cystatin C levels, inflammatory factor levels and the proportion of analgesic drugs were compared between the two groups. The drug effect of the study group was better than that of the control group (p<0.05), the symptom score, average time of residual stone excretion, levels of renal function indicators, blood creatinine and blood urea nitrogen in the study group were lower than those of the control group (p<0.05). The levels of urinary N-acetyl-beta-d-glucosaminidase, beta-2 microglobulin and cystatin C in the study group were better than those in the control group (p<0.05). The indicators of inflammatory factors and usage rate of analgesic drugs in the study group were lower than those in the control group (p<0.05). Diuretic and stone removal mixture can significantly improve the postoperative effect of extracorporeal shock wave lithotripsy, shorten the time of stone removal, increase the levels of renal function, urinary N-acetyl-beta-dglucosaminidase, beta-2 microglobulin, cystatin C, etc., improve the level of inflammatory factors and reduce the usage rate of analgesic drugs.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135595963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.1072
Nidhi Varshney, A. Prakash, D. Singh, Pracheta Janmeda
Varshney et al. : Quantitative Estimation and Antioxidant Activity of Cyperus rotundus Oxidative stress related disorders occur as a result of free radicals in the cellular organs. Antioxidants provide protection contrary to oxidative stress by counteracting free radicals through the help of different bioactive constituents present in the plants. The aim of this study is to find out the quantitative estimation of phytochemicals (phenolics, tannins, flavonoid, non-tannins, alkaloid and saponins), in vitro antioxidant activity (2, 2-diphenyl-1-picryl-hydrazyl-hydrate, metal chelating, ferric reducing, superoxide dismutase and total antioxidant activity) of different parts of Cyperus rotundus . Along with this, the extraction of polyphenolic compounds by conventional and non-conventional methods and their optimization by response surface methodology technique were also studied. As the outcomes of the study, maximum amount of total phenolics content was found in the ethanolic fraction of stem (37.88±0.94 mg gallic acid equivalent/g). The root has shown the highest flavonoid (0.24±0.03 mg QAE/g) and non-tannin content (21.55±2.43 mg gallic acid equivalent/g) in the extract of petroleum ether. The total alkaloids and tannin content in flower and root i.e., 5.05±0.08 mg caffeine equivalent/g and 76.28±0.62 mg tannic acid equivalent/g was found to be better in aqueous extract respectively. The fraction of ethyl acetate has reported the greatest saponin content (39.2±3.8 mg gallic acid equivalent/g). In case of flower part half-maximal inhibitory concentration value of 2, 2-diphenyl-1-picryl-hydrazyl-hydrate and superoxide dismutase antioxidant activity varies from 0.57-1.90 mg/ml and from 0.053-1.401 mg/ml respectively. Antioxidant activity of each part of the plant was reported in the fraction of ethanol and water by fluorescence recovery after photobleaching (0.403±0.009-0.886±0.02 mg/ml), metal chelation activity (0.010±0.0-0.306±0.001 mg/ml) and total antioxidant capacity (0.030±0.0-0.317±0.002 mg/ml). Microwave assisted extraction method was found to be the suitable one for optimization of total phenolic content. So, the relationship between different parameter was determined through response surface methodology technique and evaluated by plotting the graphs. Polar extracts have found to show the maximum quantity of secondary bioactive metabolites and antioxidant activity as compared to non-polar one. And among the comparison between conventional and non-conventional methods, ultra sonication (non-conventional method) has shown the highest yield of bioactive phenolic compound. So, this study shows that Cyperus rotundus has wide range of secondary metabolites showing antioxidant properties that can be applied for different therapeutic applications.
{"title":"In Vitro Antioxidant Assay of Different Phytoconstituents and Extraction Optimization of Phenolics from Cyperus rotundus L","authors":"Nidhi Varshney, A. Prakash, D. Singh, Pracheta Janmeda","doi":"10.36468/pharmaceutical-sciences.1072","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1072","url":null,"abstract":"Varshney et al. : Quantitative Estimation and Antioxidant Activity of Cyperus rotundus Oxidative stress related disorders occur as a result of free radicals in the cellular organs. Antioxidants provide protection contrary to oxidative stress by counteracting free radicals through the help of different bioactive constituents present in the plants. The aim of this study is to find out the quantitative estimation of phytochemicals (phenolics, tannins, flavonoid, non-tannins, alkaloid and saponins), in vitro antioxidant activity (2, 2-diphenyl-1-picryl-hydrazyl-hydrate, metal chelating, ferric reducing, superoxide dismutase and total antioxidant activity) of different parts of Cyperus rotundus . Along with this, the extraction of polyphenolic compounds by conventional and non-conventional methods and their optimization by response surface methodology technique were also studied. As the outcomes of the study, maximum amount of total phenolics content was found in the ethanolic fraction of stem (37.88±0.94 mg gallic acid equivalent/g). The root has shown the highest flavonoid (0.24±0.03 mg QAE/g) and non-tannin content (21.55±2.43 mg gallic acid equivalent/g) in the extract of petroleum ether. The total alkaloids and tannin content in flower and root i.e., 5.05±0.08 mg caffeine equivalent/g and 76.28±0.62 mg tannic acid equivalent/g was found to be better in aqueous extract respectively. The fraction of ethyl acetate has reported the greatest saponin content (39.2±3.8 mg gallic acid equivalent/g). In case of flower part half-maximal inhibitory concentration value of 2, 2-diphenyl-1-picryl-hydrazyl-hydrate and superoxide dismutase antioxidant activity varies from 0.57-1.90 mg/ml and from 0.053-1.401 mg/ml respectively. Antioxidant activity of each part of the plant was reported in the fraction of ethanol and water by fluorescence recovery after photobleaching (0.403±0.009-0.886±0.02 mg/ml), metal chelation activity (0.010±0.0-0.306±0.001 mg/ml) and total antioxidant capacity (0.030±0.0-0.317±0.002 mg/ml). Microwave assisted extraction method was found to be the suitable one for optimization of total phenolic content. So, the relationship between different parameter was determined through response surface methodology technique and evaluated by plotting the graphs. Polar extracts have found to show the maximum quantity of secondary bioactive metabolites and antioxidant activity as compared to non-polar one. And among the comparison between conventional and non-conventional methods, ultra sonication (non-conventional method) has shown the highest yield of bioactive phenolic compound. So, this study shows that Cyperus rotundus has wide range of secondary metabolites showing antioxidant properties that can be applied for different therapeutic applications.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70214768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.1074
E. T., N. S, Pai Mv, Thunga G, Kunhikatta V
A retrospective study was conducted in a tertiary care teaching hospital to evaluate the drug utilization pattern in pregnant women. A total of 876 pregnant women were enrolled in the study. Parameters such as demography, gravidity, comorbid illness, neonatal outcome, drugs prescribed and their utilization details were collected. The mean age of the study population was found to be 29.4±4.4 y (mean±standard deviation). Majority of them underwent caesarean section (68.2 %) compared to normal vaginal delivery (31.8 %). Most of the neonates were healthy (94.3 %) whereas 0.8 % of the neonates expired during the postnatal period. Diabetes mellitus (33.6 %) was the most common comorbidity, followed by hypertension (28.3 %) and thyroid disorders (18.3 %). Folic acid (15.7 %) and calcium (15.2 %) were the most prescribed drugs, followed by ferrous fumarate (7.1 %), vitamin B12 (5.3 %) and vitamin B6 (3.4 %). In terms of defined daily dose/100 bed d, levothyroxine (369.3) was the most frequently utilized drug, followed by digoxin (53.6), dydrogesterone (27.4) and salbutamol (20.5). Estradiol was only the food and drug administration pregnancy category X drug prescribed, as estradiol supplement as this was required to improve pregnancy rates after in vitro fertilization.
{"title":"Evaluation of the Drug Utilization Pattern among Pregnant Women in a Tertiary Care Teaching Hospital","authors":"E. T., N. S, Pai Mv, Thunga G, Kunhikatta V","doi":"10.36468/pharmaceutical-sciences.1074","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1074","url":null,"abstract":"A retrospective study was conducted in a tertiary care teaching hospital to evaluate the drug utilization pattern in pregnant women. A total of 876 pregnant women were enrolled in the study. Parameters such as demography, gravidity, comorbid illness, neonatal outcome, drugs prescribed and their utilization details were collected. The mean age of the study population was found to be 29.4±4.4 y (mean±standard deviation). Majority of them underwent caesarean section (68.2 %) compared to normal vaginal delivery (31.8 %). Most of the neonates were healthy (94.3 %) whereas 0.8 % of the neonates expired during the postnatal period. Diabetes mellitus (33.6 %) was the most common comorbidity, followed by hypertension (28.3 %) and thyroid disorders (18.3 %). Folic acid (15.7 %) and calcium (15.2 %) were the most prescribed drugs, followed by ferrous fumarate (7.1 %), vitamin B12 (5.3 %) and vitamin B6 (3.4 %). In terms of defined daily dose/100 bed d, levothyroxine (369.3) was the most frequently utilized drug, followed by digoxin (53.6), dydrogesterone (27.4) and salbutamol (20.5). Estradiol was only the food and drug administration pregnancy category X drug prescribed, as estradiol supplement as this was required to improve pregnancy rates after in vitro fertilization.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70214960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.1139
E. Cho, Min-Sung Ko, C. H. Lee, Sul Lee, K. Hwang, So-Young Park
{"title":"Paeoniflorin Derivaties from Peony Roots Affecting Osteoblastic and Osteoclastic Differentiation","authors":"E. Cho, Min-Sung Ko, C. H. Lee, Sul Lee, K. Hwang, So-Young Park","doi":"10.36468/pharmaceutical-sciences.1139","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1139","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69607419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.spl.615
L. Yang, Shan-Shan Sun, W. Zhu
{"title":"Efficacy of Vonoprazan Fumarate Tablets in Refractory Reflux Esophagitis","authors":"L. Yang, Shan-Shan Sun, W. Zhu","doi":"10.36468/pharmaceutical-sciences.spl.615","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.615","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.spl.633
Anwu Huang, Z. L. Wang, Qin Zhang, X. J. Ji, J. Wang, S. Chen, W. Jiang
{"title":"Advances in Hypoxia-Inducible Factor 1-Alpha and Ischemic Heart Disease","authors":"Anwu Huang, Z. L. Wang, Qin Zhang, X. J. Ji, J. Wang, S. Chen, W. Jiang","doi":"10.36468/pharmaceutical-sciences.spl.633","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.633","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69634514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.36468/pharmaceutical-sciences.1070
Defei Xian, Qin Tang
{"title":"Effect and Mechanism of Dexmedetomidine on Inhibiting Proliferation, Migration and Invasion of Ovarian Cancer Cell Strain SKOV3","authors":"Defei Xian, Qin Tang","doi":"10.36468/pharmaceutical-sciences.1070","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1070","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70214928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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