Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.04.04
W. Soewondo, Prasetyo Sarwono Putro, Muhamad Lukman Hermansah, L. Lestari, Reviono Reviono, Harsini Harsini, Artrien Adhiputri
Background: COVID-19 is a disease caused by SARS-CoV-2 and has numerous clinical spectrums. Mild respiratory infection is the common clinical manifestation of COVID-19, and the less common is pneumonia accompanied by fever, cough, and breathing difficulty. Long COVID can be defined as prolonged signs and symptoms which cannot be explained for other reasons 4 weeks after being diagnosed with SARS-CoV-2. This study aimed to describe the cause of illness is confirmed or suspected COVID-19 patients, specifically on long COVID. Subjects and Method: We performed literature searches of the latest articles with Medline, CINAHL (EBSCO), Global Health (Ovid), WHO Global Research on COVID-19 database, LitCovid and Google Scholar databases published from 2019 to 2020. Two reviewers searched all articles independently (P and W, with 7 and 10 years of experience, respectively). We conducted a systematic review to provide recent evidence of symptoms and complications in long COVID. We followed PRISMA guidelines.
背景:COVID-19是由SARS-CoV-2引起的疾病，具有多种临床谱。轻度呼吸道感染是新冠肺炎常见的临床表现，较少见的是肺炎并伴有发烧、咳嗽和呼吸困难。长冠状病毒可定义为在被诊断为SARS-CoV-2后4周内无法解释其他原因的体征和症状延长。本研究旨在描述确诊或疑似COVID-19患者的发病原因，特别是长COVID。对象和方法:检索Medline、CINAHL (EBSCO)、Global Health (Ovid)、WHO Global Research on COVID-19数据库、LitCovid和谷歌Scholar数据库2019 - 2020年发表的最新文章。两位审稿人独立检索了所有文章(P和W，分别具有7年和10年的经验)。我们进行了系统回顾，以提供长期COVID的症状和并发症的最新证据。我们遵循PRISMA的指导方针。
{"title":"Long Covid-19, Radiological Findings, and Its Management: A Systematic Review","authors":"W. Soewondo, Prasetyo Sarwono Putro, Muhamad Lukman Hermansah, L. Lestari, Reviono Reviono, Harsini Harsini, Artrien Adhiputri","doi":"10.26911/theijmed.2021.06.04.04","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.04.04","url":null,"abstract":"Background: COVID-19 is a disease caused by SARS-CoV-2 and has numerous clinical spectrums. Mild respiratory infection is the common clinical manifestation of COVID-19, and the less common is pneumonia accompanied by fever, cough, and breathing difficulty. Long COVID can be defined as prolonged signs and symptoms which cannot be explained for other reasons 4 weeks after being diagnosed with SARS-CoV-2. This study aimed to describe the cause of illness is confirmed or suspected COVID-19 patients, specifically on long COVID. Subjects and Method: We performed literature searches of the latest articles with Medline, CINAHL (EBSCO), Global Health (Ovid), WHO Global Research on COVID-19 database, LitCovid and Google Scholar databases published from 2019 to 2020. Two reviewers searched all articles independently (P and W, with 7 and 10 years of experience, respectively). We conducted a systematic review to provide recent evidence of symptoms and complications in long COVID. We followed PRISMA guidelines.","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74461068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.03.03
Ragil Aidil Fitriasari Addini, E. Pamungkasari, Bhisma Murti
{"title":"Meta-Analysis of the Effect of Pelvic Floor Muscle Training in Reducing Urinary Incontinence and Elevating Quality of Life in Women","authors":"Ragil Aidil Fitriasari Addini, E. Pamungkasari, Bhisma Murti","doi":"10.26911/theijmed.2021.06.03.03","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.03.03","url":null,"abstract":"","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"372 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80495911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.04.08
Mei Kusumaningtyas, Herdianty Kusuma Handari
{"title":"The Effects of Skipping Rope Exercise, Brisk Walking Exercise, and Weight Training on Cardiorespiratory Endurance in Physiotherapy Students","authors":"Mei Kusumaningtyas, Herdianty Kusuma Handari","doi":"10.26911/theijmed.2021.06.04.08","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.04.08","url":null,"abstract":"","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81330016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.04.07
Muhammad Dzaki Darmawan, Jarot Subandono, N. A. Setyawan, D. R. Budiani
{"title":"Effect of Ethanolic Extract in Moringa oleifera, Lam. Leaf on Uric Acid Levels and Body Surface Area of Kidney Glomerulus in Wistar Rats (Rattus novergicus) Induced Metabolic Syndrome Model","authors":"Muhammad Dzaki Darmawan, Jarot Subandono, N. A. Setyawan, D. R. Budiani","doi":"10.26911/theijmed.2021.06.04.07","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.04.07","url":null,"abstract":"","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89401476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.04.11
Bintang Soetjahjo, R. Ermawan, R. Saputra, Udi Herunefi Hancoro, Bagus Nugroho, Jiva Yori Anugra
Background: Tibial shaft fractures including open tibial fractures grade III are one of the most common fractures of long bones. There are many methods of conservative and operative treatment, one of them is external fixation. External fixation is more common used temporary in polytraumatized patients with tibial shaft fractures. The study was undertaken to see if the patient can be treated with external fixation as the definitive treatment and evaluate the functional outcome after the treatment. Subjects and Method: A retrospective review of a prospectively-collected database was performed. Data was taken from the Orthopaedic Department of RSUD Dr. Moewardi Hospital patients’ database. The study included all patients who underwent grade III open tibial fracture treatment from May 2018 to May 2019. A total of 8 patients who were included in our study were a patient with open tibial fractures grade III planned for external fixaton as definitive treatment. They were evaluated radiographically and clinically to determine the union rate. The data were reported descriptively. Results: External fixator time ranged in this study around 240 days. In this study, there were a few patients whose progress were remain unknown due to loss of contact. Fractures studied 5 out of 8, no patient were union after 8 months of external fixator used. 4 out of 8 patients were reported non-union after 8 months based on their radiological examination (50%) and 1 out of 8 patients were reported has been performed Removal of External Fixation (ROEF) after 5 months of treatment. The rest of the 3 patients’ results were remain unknown. Conclusion: Open tibial fractures grade III of the leg can be managed with use of external fixator as a definitive treatment. However, the use of external fixation does not provide maximum results in grade III A tibial fractures.
背景:胫骨干骨折包括开放性胫骨骨折III级是长骨最常见的骨折之一。保守和手术治疗的方法有很多，其中之一就是外固定。外固定支架在胫骨干骨折多发创伤患者中更为常见。该研究旨在了解患者是否可以将外固定作为最终治疗方法，并评估治疗后的功能结果。对象和方法:对前瞻性收集的数据库进行回顾性审查。数据来自RSUD Dr. Moewardi医院骨科患者数据库。该研究包括2018年5月至2019年5月期间接受III级胫骨开放性骨折治疗的所有患者。在我们的研究中，共有8例患者为III级胫骨开放性骨折患者，计划采用外固定作为最终治疗。通过影像学和临床评估来确定愈合率。数据以描述性方式报告。结果:本研究中外固定架使用时间约为240天。在本研究中，有少数患者因失联而无法得知病情进展。8例患者中有5例骨折，使用外固定架8个月后无骨折愈合。根据放射学检查，8个月后，8名患者中有4名出现骨不连(50%)，8名患者中有1名在治疗5个月后进行了外固定物移除(ROEF)。其余3例患者的结果尚不清楚。结论:外固定架是治疗III级胫骨开放性骨折的有效方法。然而，对于III级A级胫骨骨折，使用外固定架并不能提供最大的效果。
{"title":"Functional Outcome Evaluation of Grade III Open Tibial Fracture Treated by External Fixation as Definitive Treatment","authors":"Bintang Soetjahjo, R. Ermawan, R. Saputra, Udi Herunefi Hancoro, Bagus Nugroho, Jiva Yori Anugra","doi":"10.26911/theijmed.2021.06.04.11","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.04.11","url":null,"abstract":"Background: Tibial shaft fractures including open tibial fractures grade III are one of the most common fractures of long bones. There are many methods of conservative and operative treatment, one of them is external fixation. External fixation is more common used temporary in polytraumatized patients with tibial shaft fractures. The study was undertaken to see if the patient can be treated with external fixation as the definitive treatment and evaluate the functional outcome after the treatment. Subjects and Method: A retrospective review of a prospectively-collected database was performed. Data was taken from the Orthopaedic Department of RSUD Dr. Moewardi Hospital patients’ database. The study included all patients who underwent grade III open tibial fracture treatment from May 2018 to May 2019. A total of 8 patients who were included in our study were a patient with open tibial fractures grade III planned for external fixaton as definitive treatment. They were evaluated radiographically and clinically to determine the union rate. The data were reported descriptively. Results: External fixator time ranged in this study around 240 days. In this study, there were a few patients whose progress were remain unknown due to loss of contact. Fractures studied 5 out of 8, no patient were union after 8 months of external fixator used. 4 out of 8 patients were reported non-union after 8 months based on their radiological examination (50%) and 1 out of 8 patients were reported has been performed Removal of External Fixation (ROEF) after 5 months of treatment. The rest of the 3 patients’ results were remain unknown. Conclusion: Open tibial fractures grade III of the leg can be managed with use of external fixator as a definitive treatment. However, the use of external fixation does not provide maximum results in grade III A tibial fractures.","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78720946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.04.03
Arief Wahyudi Jadmiko, T. Kristina, Untung Sujianto, Yan Wisnu Prajoko, Luky Dwiantoro, A. P. Widodo
{"title":"Path analysis and structural equation model EPB2","authors":"Arief Wahyudi Jadmiko, T. Kristina, Untung Sujianto, Yan Wisnu Prajoko, Luky Dwiantoro, A. P. Widodo","doi":"10.26911/theijmed.2021.06.04.03","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.04.03","url":null,"abstract":"","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83648198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Covid-19 has been declared a pandemic since March 2020 until now, so the government requires the provision of a covid-19 vaccine for all people. The government's vaccination campaign has received various responses from the public, some people accept and some reject the Covid-19 vaccine. This study aims to determine the relationship between public perception of the acceptance of the COVID-19 vaccine in Surakarta. Subjects and Methods: The cross sectional study was conducted in Surakarta. A sample of 65 people aged >12 years was selected by random sampling. The dependent variable was the willingness to receive the covid-19 vaccine. Tthe independent variable was perception. Data was collected by online questionnaire (google form). Data were analyzed by chi square test.
{"title":"Association between Community Perception and Willingness to Vaccinated Againts COVID-19 in Surakarta, Central Java, Indonesia","authors":"Annita Viesta Nirmala Dewi, Alya Ayu Kharisma, Nailah Salma Inas, Chusna Habiba, Okti Indriyani, Caroline Dharmawan, Syarifah Jihadillah, Hibah Mujahidah, Kharisma Trisiadewi, Nabila Ramadhani, N. Wahidah, Revi Gama Hatta Novika","doi":"10.26911/theijmed.2021.06.04.09","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.04.09","url":null,"abstract":"Background: Covid-19 has been declared a pandemic since March 2020 until now, so the government requires the provision of a covid-19 vaccine for all people. The government's vaccination campaign has received various responses from the public, some people accept and some reject the Covid-19 vaccine. This study aims to determine the relationship between public perception of the acceptance of the COVID-19 vaccine in Surakarta. Subjects and Methods: The cross sectional study was conducted in Surakarta. A sample of 65 people aged >12 years was selected by random sampling. The dependent variable was the willingness to receive the covid-19 vaccine. Tthe independent variable was perception. Data was collected by online questionnaire (google form). Data were analyzed by chi square test.","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82511220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.04.02
D. Ardiyanto
Background: Osteoarthritis (OA) of the knee joint has the highest prevalence among all types of rheumatic diseases. The most common symptom of knee OA is pain around the joint. Patients with OA require long treatment, especially using analgesic and anti-inflammatory drugs. Turmeric is efficacious as a pain reliever and anti-inflammatory. This study aims to estimate the magnitude of the effect of turmeric extract (Curcuma domestica) on pain in patients with knee OA compared to placebo and non-steroidal anti-inflammatory drugs (NSAIDs), based on the results of a number of previous similar studies. Subjects and Method: This study is a systematic review and meta-analysis with the following PICO, population: patients with knee OA. Intervention: turmeric extract. Comparison: placebo and NSAIDs. Outcome: pain reduction. The articles used in this study were obtained from three databases, namely Google Scholar, Pubmed, and Science Direct. Keywords to search for articles: “Knee Osteoarthritis” OR “Knee OA” AND “Curcuma longa” OR “Curcuma domestica” OR “Turmeric extract” AND “Placebo” OR “NSAID” AND “pain” OR “visual analogue scale” OR “ VASE". The articles included are full-text with RCT study designs from 2011 to 2021. The selection of articles is carried out using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application. Results: A total of 15 RCT studies were selected for systematic review and meta-analysis. Data collected from 10 studies showed that patients with knee OA who received turmeric extract experienced 1.60 units lower joint pain than placebo (SMD= -1.60; 95% CI= -2.23 to -0.97; p<0.001). Data from 5 studies showed that patients with knee OA who received turmeric extract experienced 0.06 units higher joint pain than NSAIDs. The comparison between the turmeric extract group and the NSAID group did not show any significant difference (SMD= 0.06; 95% CI= -0.10 to -0.22; p= 0.490). Conclusion: Administration of turmeric extract was more effective than placebo and not inferior to non-steroidal anti-inflammatory drugs in reducing pain in patients with knee OA.
{"title":"Meta-Analysis the Efficacy of Turmeric (Curcuma domestica) in Reducing Pain in Patients of Knee Osteoarthritis","authors":"D. Ardiyanto","doi":"10.26911/theijmed.2021.06.04.02","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.04.02","url":null,"abstract":"Background: Osteoarthritis (OA) of the knee joint has the highest prevalence among all types of rheumatic diseases. The most common symptom of knee OA is pain around the joint. Patients with OA require long treatment, especially using analgesic and anti-inflammatory drugs. Turmeric is efficacious as a pain reliever and anti-inflammatory. This study aims to estimate the magnitude of the effect of turmeric extract (Curcuma domestica) on pain in patients with knee OA compared to placebo and non-steroidal anti-inflammatory drugs (NSAIDs), based on the results of a number of previous similar studies. Subjects and Method: This study is a systematic review and meta-analysis with the following PICO, population: patients with knee OA. Intervention: turmeric extract. Comparison: placebo and NSAIDs. Outcome: pain reduction. The articles used in this study were obtained from three databases, namely Google Scholar, Pubmed, and Science Direct. Keywords to search for articles: “Knee Osteoarthritis” OR “Knee OA” AND “Curcuma longa” OR “Curcuma domestica” OR “Turmeric extract” AND “Placebo” OR “NSAID” AND “pain” OR “visual analogue scale” OR “ VASE\". The articles included are full-text with RCT study designs from 2011 to 2021. The selection of articles is carried out using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application. Results: A total of 15 RCT studies were selected for systematic review and meta-analysis. Data collected from 10 studies showed that patients with knee OA who received turmeric extract experienced 1.60 units lower joint pain than placebo (SMD= -1.60; 95% CI= -2.23 to -0.97; p<0.001). Data from 5 studies showed that patients with knee OA who received turmeric extract experienced 0.06 units higher joint pain than NSAIDs. The comparison between the turmeric extract group and the NSAID group did not show any significant difference (SMD= 0.06; 95% CI= -0.10 to -0.22; p= 0.490). Conclusion: Administration of turmeric extract was more effective than placebo and not inferior to non-steroidal anti-inflammatory drugs in reducing pain in patients with knee OA.","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82473989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.02.02
Irfan Dzakir Nugroho, D. Hidayah, Harsono Salimo
{"title":"Comparison Neutrophil to Lymphocyte Count Ratio with C-Reactive Protein as a Predictor for Neonatal Sepsis","authors":"Irfan Dzakir Nugroho, D. Hidayah, Harsono Salimo","doi":"10.26911/theijmed.2021.06.02.02","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.02.02","url":null,"abstract":"","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"93 8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83500674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-30DOI: 10.26911/theijmed.2020.05.04.03
D. K. Mirawati, Nella Lusti Widhianingsih, Titian Rakhma, S. Subandi, R. Danuaji, P. Budianto, H. Prabaningtyas, S. E. Putra
Background: Epilepsy is one of the oldest neurological disease requiring long-term treatment. Long-term use of certain anti-epileptic drugs (AED) will strongly induce cytochrome-P450 (CYP) enzyme resulting increase of homocysteine associated with risk of cerebrovascular disease and depression. The purpose of this study was to determine relationship between serum level of ApoA, ApoB, and C-Reactive Protein (CRP) with depression in epileptic patients receiving AED therapy. Subjects and Method: Respondents of this cross-sectional study were epileptic outpatients in neurology clinic Dr. Moewardi Hospital, Surakarta receiving AED therapy and met inclusion and exclusion criteria. Depression condition was evaluated by Hamilton Depression Rating Scale (HDRS). Serum level of ApoA, ApoB, and CRP of each respondent were measured from vein blood. Data were analyzed by a multiple linear regression. Results: There were 51 epileptic patients with proportional ratio between men and women (1.2:1) with age range from 18 to 59 years old. The average length of AED 92.67 months (Mean= 92.67; SD= 91.58). Average of HDRS score was 8.49. Meanwhile, average of ApoA level was 86.14 mg/dL, average of ApoB level was 47.57 mg/dL, and average of CRP level was 0.18 mg/dL. Serum level of ApoA, ApoB, and CRP increased depression (HDRS score) in epileptic patients. Conclusion: There was a statistically significant relationship between serum level of ApoA, ApoB, and CRP with depressive condition of epileptic patients receiving long-term AED treatment. Keyword s : ApoA, ApoB, C-Reactive Protein, depression, epilepsy Correspondence: Diah Kurnia Mirawati. Neurology Department of Dr. Moewardi Regional General Hospital/ Medical Faculty of Universitas Sebelas Maret, Indonesia. Email: diahkm@staff.uns.ac.id. Indonesian Journal of Medicine (2020), 05(04): 282-290 https://doi.org/10.26911/theijmed.2020.05.04.03.
{"title":"Relationship between APO-A, APO-B, and C-reactive Protein with Depression in Epileptic Patients","authors":"D. K. Mirawati, Nella Lusti Widhianingsih, Titian Rakhma, S. Subandi, R. Danuaji, P. Budianto, H. Prabaningtyas, S. E. Putra","doi":"10.26911/theijmed.2020.05.04.03","DOIUrl":"https://doi.org/10.26911/theijmed.2020.05.04.03","url":null,"abstract":"Background: Epilepsy is one of the oldest neurological disease requiring long-term treatment. Long-term use of certain anti-epileptic drugs (AED) will strongly induce cytochrome-P450 (CYP) enzyme resulting increase of homocysteine associated with risk of cerebrovascular disease and depression. The purpose of this study was to determine relationship between serum level of ApoA, ApoB, and C-Reactive Protein (CRP) with depression in epileptic patients receiving AED therapy. Subjects and Method: Respondents of this cross-sectional study were epileptic outpatients in neurology clinic Dr. Moewardi Hospital, Surakarta receiving AED therapy and met inclusion and exclusion criteria. Depression condition was evaluated by Hamilton Depression Rating Scale (HDRS). Serum level of ApoA, ApoB, and CRP of each respondent were measured from vein blood. Data were analyzed by a multiple linear regression. Results: There were 51 epileptic patients with proportional ratio between men and women (1.2:1) with age range from 18 to 59 years old. The average length of AED 92.67 months (Mean= 92.67; SD= 91.58). Average of HDRS score was 8.49. Meanwhile, average of ApoA level was 86.14 mg/dL, average of ApoB level was 47.57 mg/dL, and average of CRP level was 0.18 mg/dL. Serum level of ApoA, ApoB, and CRP increased depression (HDRS score) in epileptic patients. Conclusion: There was a statistically significant relationship between serum level of ApoA, ApoB, and CRP with depressive condition of epileptic patients receiving long-term AED treatment. Keyword s : ApoA, ApoB, C-Reactive Protein, depression, epilepsy Correspondence: Diah Kurnia Mirawati. Neurology Department of Dr. Moewardi Regional General Hospital/ Medical Faculty of Universitas Sebelas Maret, Indonesia. Email: diahkm@staff.uns.ac.id. Indonesian Journal of Medicine (2020), 05(04): 282-290 https://doi.org/10.26911/theijmed.2020.05.04.03.","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90963601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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