Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.03.06
P. Mawardi, Bobby Febrianto, Danu Yuliarto
Background: Condyloma acuminatum (CA) is one of the most common sexually transmitted infections. Several therapeutic modalities that can be used are chemosurgery with trichloroacetic acid and cryosurgery with liquid nitrogen. Recurrence in CA often occurs, so selecting the right therapeutic modality and eliminating the lesion also prevents recurrence. This study aimed to compare the effectiveness of chemosurgery and cryosurgery therapy in patients with CA who are treated at Dr. Moewardi Hospital, Surakarta. Subjects and Method: A retrospective cross-sectional study was conducted at the Dermatology and Venereology Polyclinic, Dr. Moewardi Hospital, Surakarta, from January 1, 2018, to December 31, 2020. The study subjects were 78 patients diagnosed with CA based on ICD-10 criteria, while chemosurgery and cryosurgery procedures were based on ICD-9. The dependent variable was healing time in weeks. The independent variables were chemosurgery and cryosurgery therapy. The data came from the patient's medical record. Data were analyzed using an independent t-test. Results: Based on univariate analysis, most patients were male (67.9%), and the age group was 20-29 years (51.28%). Most of the CA patients work as private employees (46.15%). The most sexual orientation was heterosexual (53.8%), the most common site of lesions was genital (47.4%), and 52.6% were coinfected with HIV. Most CA patients received chemosurgery (70.5%). Bivariate analysis showed that chemosurgery therapy provided faster clinical improvement (Mean= 23.34; SD= 26.45) than cryosurgery therapy (Mean= 28.69; SD= 19.84), and the difference was statistically significant (p= 0.037). Conclusion: Treatment of CA using chemosurgery provides clinical improvement faster than cryosurgery, so that faster treatment time can reduce treatment costs and improve the patient's quality of life. Keywords: chemosurgery, cryosurgery, HPV, condyloma acuminatum Correspondence: Prasetyadi Mawardi. Department of Dermatology and Venereology, Faculty of Medicine of Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Central Java, Indonesia. Email: prasetyadimawardi@gmail.com/ prasetyadi_m@staff.uns.ac.id. Mobile: +6281229750211. Indonesian Journal of Medicine (2021), 06(03): 290-297 https://doi.org/10.26911/theijmed.2021.06.03.06
{"title":"Comparison of the Effectiveness of the Chemosurgery and Cryosurgery for the Treatment of Patients with Condyloma Acuminatum at Dr. Moewardi Hospital, Surakarta","authors":"P. Mawardi, Bobby Febrianto, Danu Yuliarto","doi":"10.26911/theijmed.2021.06.03.06","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.03.06","url":null,"abstract":"Background: Condyloma acuminatum (CA) is one of the most common sexually transmitted infections. Several therapeutic modalities that can be used are chemosurgery with trichloroacetic acid and cryosurgery with liquid nitrogen. Recurrence in CA often occurs, so selecting the right therapeutic modality and eliminating the lesion also prevents recurrence. This study aimed to compare the effectiveness of chemosurgery and cryosurgery therapy in patients with CA who are treated at Dr. Moewardi Hospital, Surakarta. Subjects and Method: A retrospective cross-sectional study was conducted at the Dermatology and Venereology Polyclinic, Dr. Moewardi Hospital, Surakarta, from January 1, 2018, to December 31, 2020. The study subjects were 78 patients diagnosed with CA based on ICD-10 criteria, while chemosurgery and cryosurgery procedures were based on ICD-9. The dependent variable was healing time in weeks. The independent variables were chemosurgery and cryosurgery therapy. The data came from the patient's medical record. Data were analyzed using an independent t-test. Results: Based on univariate analysis, most patients were male (67.9%), and the age group was 20-29 years (51.28%). Most of the CA patients work as private employees (46.15%). The most sexual orientation was heterosexual (53.8%), the most common site of lesions was genital (47.4%), and 52.6% were coinfected with HIV. Most CA patients received chemosurgery (70.5%). Bivariate analysis showed that chemosurgery therapy provided faster clinical improvement (Mean= 23.34; SD= 26.45) than cryosurgery therapy (Mean= 28.69; SD= 19.84), and the difference was statistically significant (p= 0.037). Conclusion: Treatment of CA using chemosurgery provides clinical improvement faster than cryosurgery, so that faster treatment time can reduce treatment costs and improve the patient's quality of life. Keywords: chemosurgery, cryosurgery, HPV, condyloma acuminatum Correspondence: Prasetyadi Mawardi. Department of Dermatology and Venereology, Faculty of Medicine of Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Central Java, Indonesia. Email: prasetyadimawardi@gmail.com/ prasetyadi_m@staff.uns.ac.id. Mobile: +6281229750211. Indonesian Journal of Medicine (2021), 06(03): 290-297 https://doi.org/10.26911/theijmed.2021.06.03.06","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79394858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.02.04
Hanung Prasetya, H. N. Kusumawati, Wardiyatmi Wardiyatmi
{"title":"The Effectiveness of Hypnotherapy in Reducing Pain in Patients with Cervical Cancer","authors":"Hanung Prasetya, H. N. Kusumawati, Wardiyatmi Wardiyatmi","doi":"10.26911/theijmed.2021.06.02.04","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.02.04","url":null,"abstract":"","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74424498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.03.04
Pamudji Utomo, Mochamadsyah Beizar Yudhistira
Background: Pneumatic tourniquet commonly used for orthopedic surgery is associated with morbidity related to ischemia-reperfusion injury. Ischaemia conditioning (IC) had shown beneficial effects to attenuate these outcomes. This study aimed to systematically review the evidence of IC effect on outcomes of the patient undergoing orthopedic surgery. Subjects and Method: This was a systematic review and Meta-Analysis conducted through the online database search from PubMed, Central, Clinicaltrials.gov, and Scopus with topics related to IC and all possible orthopedic surgical interventions. Articles were searched with Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) protocols used keywords "Ischemic conditioning," "Reperfusion injury," "Orthopaedic surgery." The data were extracted from the eligible study within inclusion and exclusion criteria. Two independent reviewers collected the study characteristics. Each study was examined for the risk of bias. The pooled data were analyzed using RevMan 5.3 in Standardized Mean Difference (SMD) as a summary measure with 95% Confidence Interval (CI). Results: Out of 12 eligible studies collected for qualitative analysis, eight studies with the same outcomes were analyzed for quantitative analysis. A random-effect model was used for analysis with high heterogeneity. The pooled SMD data for IC compared to control for postoperative pain were -0.50 (95% CI= -0.95 to 0.06; p<0.001). Outcome measures for hemodynamic stability, systemic inflammation, and end-organ injury were pooled with MD= 4.81 (95% CI= 3.19 to 6.44); SMD= -1.33 (95% CI= -2.06 to -0.60); SMD= 0.15 (95% CI= -0.14 to 0.71); respectively. Conclusion: Ischaemic conditioning significantly reduces postoperative pain, inflammation response and maintains hemodynamic stability. A better study design with a higher population number is needed for further study.
{"title":"Meta-Analysis of Re-perfusion Injury and Ischaemic Conditioning in Limb Surgery","authors":"Pamudji Utomo, Mochamadsyah Beizar Yudhistira","doi":"10.26911/theijmed.2021.06.03.04","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.03.04","url":null,"abstract":"Background: Pneumatic tourniquet commonly used for orthopedic surgery is associated with morbidity related to ischemia-reperfusion injury. Ischaemia conditioning (IC) had shown beneficial effects to attenuate these outcomes. This study aimed to systematically review the evidence of IC effect on outcomes of the patient undergoing orthopedic surgery. Subjects and Method: This was a systematic review and Meta-Analysis conducted through the online database search from PubMed, Central, Clinicaltrials.gov, and Scopus with topics related to IC and all possible orthopedic surgical interventions. Articles were searched with Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) protocols used keywords \"Ischemic conditioning,\" \"Reperfusion injury,\" \"Orthopaedic surgery.\" The data were extracted from the eligible study within inclusion and exclusion criteria. Two independent reviewers collected the study characteristics. Each study was examined for the risk of bias. The pooled data were analyzed using RevMan 5.3 in Standardized Mean Difference (SMD) as a summary measure with 95% Confidence Interval (CI). Results: Out of 12 eligible studies collected for qualitative analysis, eight studies with the same outcomes were analyzed for quantitative analysis. A random-effect model was used for analysis with high heterogeneity. The pooled SMD data for IC compared to control for postoperative pain were -0.50 (95% CI= -0.95 to 0.06; p<0.001). Outcome measures for hemodynamic stability, systemic inflammation, and end-organ injury were pooled with MD= 4.81 (95% CI= 3.19 to 6.44); SMD= -1.33 (95% CI= -2.06 to -0.60); SMD= 0.15 (95% CI= -0.14 to 0.71); respectively. Conclusion: Ischaemic conditioning significantly reduces postoperative pain, inflammation response and maintains hemodynamic stability. A better study design with a higher population number is needed for further study.","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84919227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.03.05
Rakhmawati Susetyaning Eri, Sulistyani Kusumaningrum, W. Widiastuti, Hari Wujoso, I. B. P. Adnyana, Prasetyo Sarwono Putro
{"title":"The Relationship between Tumor Size and Carcinoembryonic Antigen (CEA) Levels in Stage IV Colorectal Adenocarcinoma Patients at Dr. Moewardi Hospital, Indonesia","authors":"Rakhmawati Susetyaning Eri, Sulistyani Kusumaningrum, W. Widiastuti, Hari Wujoso, I. B. P. Adnyana, Prasetyo Sarwono Putro","doi":"10.26911/theijmed.2021.06.03.05","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.03.05","url":null,"abstract":"","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87349933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.03.09
Happy Nurhayati, Eti Poncorini Pamungkasari, Bhisma Murti
Background: Viscoelastic coagulation testing in COVID-19 patients often found elevated concentrations of D-dimer and fibrinogen. Thrombotic complications can be in the form of Venous Thromboembolism (VTE), where this thrombotic disease is one of the factors associated with increased mortality of COVID-19 patients. This study aims to analyze the effectiveness of antiplatelet drugs in reducing mortality in COVID-19 patients. Subjects and Method: This is a meta-analysis study using PRISMA flowchart guidelines. The article search process was carried out between 2020-2021 using PubMed, Science Direct, Google Scholar, and Scopus databases. The article search was carried out by considering the eligibility criteria defined in the PICO model. Population= COVID-19 patients, Intervention= using antiplatelet drugs, Comparison= not using anticoagulant drugs, Outcome= mortality. The keywords used were "antiplatelet" AND "mortality" AND "COVID-19". The inclusion criteria used were English full-text cohort papers and the relationship measure used as the adjusted odds ratio (aOR). Based on the database, 9 articles fulfilled the inclusion criteria. The analysis was carried out using RevMan 5.3 software.
{"title":"Meta-Analysis of the Effectiveness of Using Antiplatelet Drugs Uptake in Decreasing Mortality in COVID-19 Patients","authors":"Happy Nurhayati, Eti Poncorini Pamungkasari, Bhisma Murti","doi":"10.26911/theijmed.2021.06.03.09","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.03.09","url":null,"abstract":"Background: Viscoelastic coagulation testing in COVID-19 patients often found elevated concentrations of D-dimer and fibrinogen. Thrombotic complications can be in the form of Venous Thromboembolism (VTE), where this thrombotic disease is one of the factors associated with increased mortality of COVID-19 patients. This study aims to analyze the effectiveness of antiplatelet drugs in reducing mortality in COVID-19 patients. Subjects and Method: This is a meta-analysis study using PRISMA flowchart guidelines. The article search process was carried out between 2020-2021 using PubMed, Science Direct, Google Scholar, and Scopus databases. The article search was carried out by considering the eligibility criteria defined in the PICO model. Population= COVID-19 patients, Intervention= using antiplatelet drugs, Comparison= not using anticoagulant drugs, Outcome= mortality. The keywords used were \"antiplatelet\" AND \"mortality\" AND \"COVID-19\". The inclusion criteria used were English full-text cohort papers and the relationship measure used as the adjusted odds ratio (aOR). Based on the database, 9 articles fulfilled the inclusion criteria. The analysis was carried out using RevMan 5.3 software.","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81821119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.01.12
Hisyam Syafi’ie, Hanung Prasetya, Bhisma Murti
Background: Neck pain is the fourth leading cause of disability, with an annual prevalence rate exceeding 30%. Nearly 50% of individuals will continue to experience pain or it often occurs to some degree. This study aimed to analyze the magnitude of the effect of using a cervical collar on reducing the degree of pain in neck pain patients compared to manual therapy (exercises). Subjects and Method: This research is a systematic review and meta-analysis carried out by following the PRISM diagram flow. The process of searching for articles through a journal database that includes: PubMed, Google Scholar and Science Direct by selecting articles published in 2000-2020. The keywords used include: “cervical collar” OR “neck collar” OR “soft collar” OR “hard collar” AND “neck pain” AND “cervical pain” AND “cervical radiculopathy” AND “cervical syndrome” AND “randomized controlled trial”. The inclusion criteria were full paper articles with a randomized controlled trial study design, articles using English and Indonesian, and bivariate analysis with adjusted odds ratio. Articles that meet the requirements are analyzed using the Revman 5.3 application. Results: A total of 6 articles were reviewed in this study with a randomized controlled trial study design. Meta-analysis of 6 randomized controlled trial (RCT) studies showed that there was no difference in effectiveness in using cervical collars compared to manual therapy (exercises) in reducing neck pain (ES = 0.04; 95% CI -0.31 to 0.39; p = 0.083). Conclusion: This meta-analysis concluded that there was no difference in effectiveness between the use of cervical collars and manual therapy (exercises) in reducing the degree of pain in neck pain.
背景:颈痛是第四大致残原因，年患病率超过30%。近50%的人会继续经历疼痛，或者在某种程度上经常发生。本研究旨在分析与手工治疗(运动)相比，使用颈项圈对减轻颈部疼痛患者疼痛程度的影响程度。对象与方法:本研究遵循PRISM图流程进行系统综述和meta分析。通过期刊数据库搜索文章的过程，包括:PubMed, Google Scholar和Science Direct，通过选择2000-2020年发表的文章。关键词包括:“颈领”、“颈领”、“软领”、“硬领”、“颈痛”、“颈神经根病”、“颈综合征”、“随机对照试验”。纳入标准为采用随机对照试验研究设计的论文全文、使用英语和印尼语的文章，以及采用调整优势比的双变量分析。使用Revman 5.3应用程序对满足要求的文章进行分析。结果:本研究共纳入6篇文献，采用随机对照试验研究设计。对6项随机对照试验(RCT)研究的荟萃分析显示，使用颈项圈与手工疗法(运动)在减轻颈部疼痛方面的有效性无差异(ES = 0.04;95% CI -0.31 ~ 0.39;P = 0.083)。结论:本荟萃分析的结论是，使用颈项圈和手工疗法(运动)在减轻颈部疼痛程度方面的有效性没有差异。
{"title":"The Effect of the Use of Cervical Collar on the Reduction of Neck Pain: Meta-Analysis","authors":"Hisyam Syafi’ie, Hanung Prasetya, Bhisma Murti","doi":"10.26911/theijmed.2021.06.01.12","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.01.12","url":null,"abstract":"Background: Neck pain is the fourth leading cause of disability, with an annual prevalence rate exceeding 30%. Nearly 50% of individuals will continue to experience pain or it often occurs to some degree. This study aimed to analyze the magnitude of the effect of using a cervical collar on reducing the degree of pain in neck pain patients compared to manual therapy (exercises). Subjects and Method: This research is a systematic review and meta-analysis carried out by following the PRISM diagram flow. The process of searching for articles through a journal database that includes: PubMed, Google Scholar and Science Direct by selecting articles published in 2000-2020. The keywords used include: “cervical collar” OR “neck collar” OR “soft collar” OR “hard collar” AND “neck pain” AND “cervical pain” AND “cervical radiculopathy” AND “cervical syndrome” AND “randomized controlled trial”. The inclusion criteria were full paper articles with a randomized controlled trial study design, articles using English and Indonesian, and bivariate analysis with adjusted odds ratio. Articles that meet the requirements are analyzed using the Revman 5.3 application. Results: A total of 6 articles were reviewed in this study with a randomized controlled trial study design. Meta-analysis of 6 randomized controlled trial (RCT) studies showed that there was no difference in effectiveness in using cervical collars compared to manual therapy (exercises) in reducing neck pain (ES = 0.04; 95% CI -0.31 to 0.39; p = 0.083). Conclusion: This meta-analysis concluded that there was no difference in effectiveness between the use of cervical collars and manual therapy (exercises) in reducing the degree of pain in neck pain.","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85883093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.04.01
M. Lafif, Bhisma Murti, Hanung Prasetya
{"title":"Meta-Analysis of the Role of Varenicline in Smoking Cessation","authors":"M. Lafif, Bhisma Murti, Hanung Prasetya","doi":"10.26911/theijmed.2021.06.04.01","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.04.01","url":null,"abstract":"","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90553495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.03.07
Reviono Reviono, Y. Sutanto, Harsini Harsini, L. Saptawati, M. Marwoto, B. Suryawati, Dhani Redhono, Pribadi M Sebayang
{"title":"The Agreement of Immunoglobulin Gamma Release Assay (IGRA)/ T-SPOT Tuberculosis and Tuberculin Skin Test to Detect Latent TB Infection in Diabetes Mellitus Patients","authors":"Reviono Reviono, Y. Sutanto, Harsini Harsini, L. Saptawati, M. Marwoto, B. Suryawati, Dhani Redhono, Pribadi M Sebayang","doi":"10.26911/theijmed.2021.06.03.07","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.03.07","url":null,"abstract":"","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75134351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Gestational diabetes mellitus is a serious complication of pregnancy, this is due to impaired carbohydrate tolerance which results in increased blood sugar levels and was first noticed during pregnancy. Gestational diabetes mellitus is a global problem in terms of its incidence and impact. Studies suggest that obesity and a family history of diabetes mellitus are important risk factors for gestational diabetes mellitus. This study aimed to analyze the influence of obesity and family history of diabetes mellitus on the incidence of gestational diabetes mellitus by meta-analysis. Subjects and Method: This was a systematic review and meta-analysis carried out by following the PRISMA flow diagram. The electronic database for article searches is as follows: PubMed, Science Direct, Springer Link, Scopus, and Google Scholar. The search for articles was carried out on articles published from 2010 to 2020. The keywords used were "gestational diabetes mellitus AND obesity", "gestational diabetes mellitus AND family history. The inclusion criteria were full text articles, used English, cross-sectional study design, and results reported in adjusted odds ratio (aOR). P= Pregnant mother. I= Obesity and family history of diabetes mellitus. C= No obesity and no family history of diabetes mellitus. O= gestational diabetes mellitus. Articles that meet the requirements are analyzed using the Revman 5.3. Results: Nine articles were reviewed in this study with a total of 11,657 subjects. The results of the meta-analysis showed that obesity increased the risk of gestational diabetes mellitus 1.81 times compared with non-obese (aOR= 1.81; 95% CI= 1.53 to 2.15; p <0.001). Having a family history of diabetes mellitus increased the risk of gestational diabetes mellitus 2.08 times compared with those without a family history of diabetes mellitus (aOR= 2.08; 95% CI= 1.34 to 3.22; p <0.001). Conclusion: Obesity and a family history of diabetes mellitus increase the risk of gestational diabetes mellitus.
{"title":"Meta-Analysis: Effects of Obesity and Family History of Diabetes Mellitus on the Risk of Gestational Diabetes Mellitus","authors":"Galuh Sitorukmi, Yulia Lanti Retno Dewi, Bhisma Murti","doi":"10.26911/theijmed.2021.06.01.01","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.01.01","url":null,"abstract":"Background: Gestational diabetes mellitus is a serious complication of pregnancy, this is due to impaired carbohydrate tolerance which results in increased blood sugar levels and was first noticed during pregnancy. Gestational diabetes mellitus is a global problem in terms of its incidence and impact. Studies suggest that obesity and a family history of diabetes mellitus are important risk factors for gestational diabetes mellitus. This study aimed to analyze the influence of obesity and family history of diabetes mellitus on the incidence of gestational diabetes mellitus by meta-analysis. Subjects and Method: This was a systematic review and meta-analysis carried out by following the PRISMA flow diagram. The electronic database for article searches is as follows: PubMed, Science Direct, Springer Link, Scopus, and Google Scholar. The search for articles was carried out on articles published from 2010 to 2020. The keywords used were \"gestational diabetes mellitus AND obesity\", \"gestational diabetes mellitus AND family history. The inclusion criteria were full text articles, used English, cross-sectional study design, and results reported in adjusted odds ratio (aOR). P= Pregnant mother. I= Obesity and family history of diabetes mellitus. C= No obesity and no family history of diabetes mellitus. O= gestational diabetes mellitus. Articles that meet the requirements are analyzed using the Revman 5.3. Results: Nine articles were reviewed in this study with a total of 11,657 subjects. The results of the meta-analysis showed that obesity increased the risk of gestational diabetes mellitus 1.81 times compared with non-obese (aOR= 1.81; 95% CI= 1.53 to 2.15; p <0.001). Having a family history of diabetes mellitus increased the risk of gestational diabetes mellitus 2.08 times compared with those without a family history of diabetes mellitus (aOR= 2.08; 95% CI= 1.34 to 3.22; p <0.001). Conclusion: Obesity and a family history of diabetes mellitus increase the risk of gestational diabetes mellitus.","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"319 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85425408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.26911/theijmed.2021.06.02.03
Jekson Martiar Siahaan, Endy Juli Anto, Tengku Muhammad Fauzi
{"title":"The Effects of Ethanol Extract, Chayote (Sechium Edule (Jacq.) Swartz) Fraction and Juice on the High-density Lipoprotein Level in Male White Mice","authors":"Jekson Martiar Siahaan, Endy Juli Anto, Tengku Muhammad Fauzi","doi":"10.26911/theijmed.2021.06.02.03","DOIUrl":"https://doi.org/10.26911/theijmed.2021.06.02.03","url":null,"abstract":"","PeriodicalId":13354,"journal":{"name":"IJAAM (Indonesian Journal of Anti-Aging Medicine)","volume":"109 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73547124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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