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Dermoscopy of Familial Gigantic Melanocytosis: A Report of Rare Entity. 家族性巨型黑色素细胞增多症的皮肤镜检查:罕见病例报告
IF 1.7 4区 医学 Q4 DERMATOLOGY Pub Date : 2024-08-19 DOI: 10.4103/ijd.ijd_313_23
Balachandra S Ankad,Balkrishna P Nikam,Eshritha Chigurupati
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引用次数: 0
Isolated Tubular Apocrine Adenoma of Axilla: Atypical Microscopic Manifestations in an Uncommon Entity. 腋窝孤立的管状分泌腺瘤:一种不常见实体中的非典型显微表现。
IF 1.7 4区 医学 Q4 DERMATOLOGY Pub Date : 2024-08-19 DOI: 10.4103/ijd.ijd_71_24
Seetu Palo,Shrinivas Bheemrao Somalwar,Krishna Ramavath
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引用次数: 0
A Clinico-Epidemiological Study on Porokeratosis 关于角化病的临床流行病学研究
IF 1.7 4区 医学 Q4 DERMATOLOGY Pub Date : 2024-08-19 DOI: 10.4103/ijd.ijd_131_24
Trishala Shirahatti, H Bangaru, S Sathish

Porokeratosis (PK) is a chronic progressive disorder of keratinization characterized clinically by hyperkeratotic papules or plaques surrounded by a threadlike, elevated border that expands centrifugally. Pathogenesis involves heterozygous mutations in mevalonate kinase enzyme. The most common variants are disseminated superficial actinic porokeratosis (DSAP) and PK of Mibelli. All forms show a thin column of parakeratosis, the cornoid lamella, representing the active border. Dermoscopy reveals central brownish discoloration surrounded by a single hypopigmented band and a peripheral ‘white track’. Long-standing cases of PK may undergo malignant transformation. UV-protection and topical agents, such as 5-fluorouracil, imiquimod, calcipotriol, tretinoin and oral retinoids are helpful. To study the clinical and epidemiological pattern of PK and the clinico-dermoscopic and histopathological correlation of PK. A prospective cross-sectional study was conducted on the patients attending the dermatology outpatient department (OPD) over 9 months with suspected features of PK. These patients were evaluated clinically and subjected to dermoscopy and histopathology. Statistical Package for the Social Sciences (SPSS) Of 11 patients, there were four (36.36%) males and seven (63.66%) females. The youngest was 18-year-old boy, and the eldest was 63-year-old man. The clinically most common type was PK of Mibelli with five (45.45%) cases. The most common dermoscopic feature observed was double-marginated, white peripheral border. The most common histopathological feature noted was cornoid lamella. PK is a rare skin disorder with a wide spectrum of clinical variants. Dermoscopy and histopathology aid in diagnosis, whereas dermoscopy plays a pivotal role in early and non-invasive diagnosis. Regular follow-up is mandatory to watch for the development of malignancies in a few variants.

角化过度症(Porokeratosis,PK)是一种慢性进行性角化障碍疾病,临床特征为角化过度的丘疹或斑块,周围有线状隆起的边界,边界向中心扩展。发病机制涉及甲羟戊酸激酶的杂合突变。最常见的变种是播散性表浅光化性角化病(DSAP)和米贝利角化病(PK of Mibelli)。所有类型的病例都会出现一列薄薄的角化不全,即代表活动边界的角质层。皮肤镜检查会发现中央有褐色变色,周围有一条色素沉着带和一条外围的 "白道"。病程较长的 PK 病例可能会发生恶性转化。紫外线防护和外用药物(如 5-氟尿嘧啶、咪喹莫特、钙泊三醇、曲替诺和口服维甲酸)对治疗有帮助。研究 PK 的临床和流行病学模式,以及 PK 的临床皮肤镜和组织病理学相关性。我们对皮肤科门诊部(OPD)9个月来就诊的疑似PK患者进行了一项前瞻性横断面研究。这些患者接受了临床评估、皮肤镜检查和组织病理学检查。社会科学统计软件包(SPSS 11 名患者中有 4 名男性(36.36%)和 7 名女性(63.66%)。年龄最小的是 18 岁的男孩,最大的是 63 岁的男性。临床上最常见的类型是米贝利型 PK,有 5 例(45.45%)。皮肤镜观察到的最常见特征是双边缘、周边白色边界。最常见的组织病理学特征是粟粒状薄片。PK是一种罕见的皮肤疾病,临床变异范围很广。皮肤镜检查和组织病理学检查有助于诊断,而皮肤镜检查在早期无创诊断中起着关键作用。在少数变异中,必须定期随访,以观察恶性肿瘤的发展。
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引用次数: 0
Irritant Contact Dermatitis from Accidental Exposure to a Kitchen Degreaser. 意外接触厨房除油剂引发刺激性接触性皮炎。
IF 1.7 4区 医学 Q4 DERMATOLOGY Pub Date : 2024-08-19 DOI: 10.4103/ijd.ijd_396_23
Tejasvi Dwivedi,Sri Sai Kaumudi Chirumamilla,Jivtesh Singh,Satyaki Ganguly
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引用次数: 0
Dapagliflozin-Induced Cutaneous Vasculitis, a Hitherto Unreported Adverse Effect. 达帕格列净诱发皮肤血管炎--一种迄今未报告的不良反应
IF 1.7 4区 医学 Q4 DERMATOLOGY Pub Date : 2024-08-19 DOI: 10.4103/ijd.ijd_211_24
Surjyamukhi Bhattacharyya,Aparajita Ghosh
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引用次数: 0
A Case of Progressive Lipoatrophy due to Lupus Erythematosus Panniculitis Induced by Quadrivalent Human Papillomavirus Vaccine. 四价人类乳头瘤病毒疫苗诱发的红斑狼疮泛发性进行性脂肪萎缩病例。
IF 1.7 4区 医学 Q4 DERMATOLOGY Pub Date : 2024-08-19 DOI: 10.4103/ijd.ijd_794_23
Nao Kawano,Takahiro Shiratori
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引用次数: 0
Refractory Giant Perianal Pyoderma Gangrenosum Successfully Treated with Tofacitinib. 托法替尼成功治疗难治性巨型肛周脓皮病
IF 1.7 4区 医学 Q4 DERMATOLOGY Pub Date : 2024-08-19 DOI: 10.4103/ijd.ijd_1109_23
Yu Xiao,Shuanglu Liao,Danchen Hu,Ruoyu Li,Ping Tu,Xiaowen Wang,Shaomin Zhong
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引用次数: 0
Comparison of the Diagnostic Accuracy of Teledermoscopy, Face-to-Face Examinations and Artificial Intelligence in the Diagnosis of Melanoma. 比较远程皮肤镜、面对面检查和人工智能在诊断黑色素瘤中的准确性。
IF 1.7 4区 医学 Q4 DERMATOLOGY Pub Date : 2024-08-19 DOI: 10.4103/ijd.ijd_61_24
Taraneh Yazdanparast,Mansour Shamsipour,Azin Ayatollahi,Shohreh Delavar,Maryam Ahmadi,Aniseh Samadi,Alireza Firooz
BackgroundRapid diagnosis of melanoma is necessary for a good prognosis. Using teledermatology and artificial intelligence for this issue is developing, but its diagnostic accuracy is less measured in a clinical setting.ObjectiveThe purpose of this study was to assess the diagnostic accuracy of the teledermoscopy method using the FotoFinder device as well as the Moleanalyzer Pro artificial intelligence (AI) Assistant and to compare them with the face-to-face clinical examination for the diagnosis of melanoma confirmed with histopathology.MethodsThirty melanocytic moles of 29 patients were included in the study. Each mole was assessed face-to-face, using FotoFinder teledermoscopy and Moleanalyzer Pro software methods. The results obtained from each method were compared with the results of the gold standard (pathology). The sensitivity and specificity of the three methods were calculated for malignant and borderline versus benign lesions. Inter-method reliability between a gold standard and other methods was evaluated using per cent agreement and Cohen's kappa coefficient.ResultsFive moles had a histopathological diagnosis of melanoma, and six and 19 moles were diagnosed as borderline and benign, respectively. Sensitivities and specificities were, respectively, as follows: face-to-face (90.9%, 57.9%), FotoFinder teledermoscopy (63.6%, 78.9%), FotoFinder® Moleanalyzer Pro (36.4%, 42.1%). Agreement with biopsy-obtained diagnosis categories of benign, borderline and malignant for face-to-face was 63.33%, FotoFinder teledermoscopy 73.33%, and FotoFinder® Moleanalyzer Pro 40%.ConclusionsTeledermoscopy had the highest agreement with reference diagnosis as well as the highest specificities that caused a reduction of biopsy referrals. The FotoFinder® Moleanalyzer Pro had the lowest agreement. Therefore, it cannot replace dermatologist decision making.
背景黑色素瘤的快速诊断对良好的预后至关重要。本研究的目的是评估使用 FotoFinder 设备和 Moleanalyzer Pro 人工智能(AI)助手的皮肤远程镜检查方法的诊断准确性,并将其与经组织病理学确诊的黑色素瘤的面对面临床检查进行比较。采用 FotoFinder teledermoscopy 和 Moleanalyzer Pro 软件方法对每个痣进行面对面评估。每种方法得出的结果都与金标准(病理学)的结果进行了比较。计算了三种方法对恶性病变、边缘性病变和良性病变的敏感性和特异性。结果5颗痣经组织病理学诊断为黑色素瘤,6颗痣和19颗痣分别被诊断为边缘性痣和良性痣。灵敏度和特异度分别为:面对面(90.9%,57.9%)、FotoFinder 远程皮肤镜(63.6%,78.9%)、FotoFinder® Moleanalyzer Pro(36.4%,42.1%)。面对面检查与活组织检查获得的良性、边缘性和恶性诊断类别的一致性为 63.33%,FotoFinder 远程皮肤镜为 73.33%,FotoFinder® Moleanalyzer Pro 为 40%。结论远程皮肤镜与参考诊断的一致性最高,特异性也最高,从而减少了活组织检查的转诊。FotoFinder® Moleanalyzer Pro的一致性最低。因此,它不能取代皮肤科医生的决策。
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引用次数: 0
Fever with Rash in a Child: Revisited 儿童发热伴皮疹:重温
IF 1.7 4区 医学 Q4 DERMATOLOGY Pub Date : 2024-06-26 DOI: 10.4103/ijd.ijd_913_23
Rashmi Sarkar, Anukriti Yadav, Apoorva Maheshwari

Rash and fever are some of the most common chief complaints present in paediatric dermatology emergencies. The spectrum of differential diagnosis is broad, including many different infectious and some non-infectious agents. A systematic approach involving detailed history taking, careful clinical examination along with particular attention to epidemiological features are the most important factors to make a diagnosis. This article reviews the morphological patterns of various causes of fever with rash in children, including infectious as well as non-infectious causes, with special emphasis on the Indian scenario. We intend to highlight the clinical characteristics of each cause, which will not only help make a clinical diagnosis but also distinguish benign versus life-threatening causes of skin rash in febrile paediatric patients and provide early medical intervention.

皮疹和发烧是儿科皮肤病急诊中最常见的主诉症状。鉴别诊断的范围很广,包括许多不同的感染性病原体和一些非感染性病原体。详细询问病史、仔细进行临床检查并特别注意流行病学特征是做出诊断的最重要因素。本文回顾了儿童发热伴皮疹的各种病因的形态模式,包括感染性和非感染性病因,并特别强调了印度的情况。我们希望强调每种病因的临床特征,这不仅有助于临床诊断,还能区分发热儿科患者皮疹的良性病因和危及生命的病因,并提供早期医疗干预。
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引用次数: 0
Management of Pustular Psoriasis; The Way Ahead 脓疱型银屑病的治疗;未来之路
IF 1.7 4区 医学 Q4 DERMATOLOGY Pub Date : 2024-06-26 DOI: 10.4103/ijd.ijd_165_24
Shrichand G. Parasramani, Bikash R. Kar, Sushil Tahiliani, Anchala Parthasarathi, Shekhar Neema, Satyaki Ganguly, Dharshini Sathishkumar, K Venkatachalam, Haritha Komeravelli, Jayakar Thomas

Pustular psoriasis is a specialized variant of psoriasis which can be life threatening if not treated at the earliest. The pathogenesis has been recently linked to the role of interleukin 36. Apart from the corticosteroids, systemic antipsoriatics like acitretin, cyclosporine and methotrexate have been used with some success though unpredictable. With recent identification of role of IL-36 in the pathogenesis of pustular psoriasis, biologics targeting the IL-36 receptors have been used to manage the situation with high degree of success. This narrative review deals with the recent concepts of pathogenesis of pustular psoriasis as well as the current management scenario.

脓疱型银屑病是银屑病的一种特殊变异型,如果不尽早治疗,可能会危及生命。其发病机制最近与白细胞介素 36 的作用有关。除皮质类固醇激素外,阿昔曲汀、环孢素和甲氨蝶呤等全身性抗肿瘤药物也已被使用,但效果并不理想。最近,IL-36 在脓疱型银屑病发病机制中的作用被确认,针对 IL-36 受体的生物制剂已被用于治疗脓疱型银屑病,并取得了很大成功。本综述将介绍脓疱型银屑病发病机制的最新概念以及目前的治疗方案。
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Indian Journal of Dermatology
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