Indian Journal of Dermatology最新文献

It is known that quercetin is useful in the treatment of pressure wounds due to its ability to reduce oxygen radicals, but its effect on eyelid wound healing is unclear. In this study, forty male Wistar albino rats weighing 250-300 grams were used to investigate the effect of quercetin on eyelid wound healing. Four groups were created: control group, sham group, incision wound group, and suture + quercetin group. Full-thickness skin excision was performed through a 3-5 mm incision in the superior palpebrae to create a wound. On the 1 third and seventh days, the rats were sacrificed, and blood samples were taken by cardiac puncture for biochemical measurement and tissue samples for histopathological examination from the palpebrae. 2 Inflammatory cells in the quercetin group were significantly lower on day 3 (P < 0.05). Blood levels of IL-1 and TNF-α were significantly lower in the quercetin group compared to other groups (P < 0.05). Also, IL-6 was found to be significantly lower on day 7 in the quercetin group compared to other groups (P < 0.05). The quercetin group was as effective as the sham group in terms of collagen formation on day 3, and the hydroxyproline value was significantly higher. Total oxidant status levels were lower in the quercetin group than in the sham group (P = 0.005). In conclusion, quercetin exhibited anti-inflammatory and antioxidant effects, along with higher collagen accumulation in the eyelid compared to other groups. Our results suggest that quercetin could be a potential therapeutic agent that accelerates wound healing and reduces scar formation in the eyelid.

Eczema Herpeticum (EH) or Kaposi's Varicelliform eruption (KVE) is a severe viral infection that occurs when herpes simplex virus infects an inflamed skin, most often occurring in patients with atopic dermatitis (AD) or other inflammatory skin conditions. To discern various primary dermatoses in which KVE occurred and to study the clinical features, course, and response to specific antiviral treatment along with a course of the primary dermatoses during the episode of KVE. Data was collected in the Dermatology Out-patient department of a tertiary care center in Northern India from December 2017 to March 2024, and it was tabulated and analysed. Out of 14 patients in our study, 57% (n = 8) were male, and 43% (n = 6) were female, with an M: F ratio of 1.3:1. The mean age of presentation was 44.8 years. Eczema herpeticum was present underlying the following primary diseases where, in our study, the maximum patients were of Contact dermatitis 22% (n = 3), followed by Tinea corporis 14.5% (n = 2), Psoriasis 14.5% (n = 2), 7% each of Pemphigus vulgaris (n = 1), Atopic dermatitis (n = 1), Seborrheic dermatitis (n = 1), Burn (n = 1), Lichen simplex chronicus (n = 1), Hansen's disease with Dapsone hypersensitivity syndrome (n = 1) and Tuberculosis (n = 1). KVE underscores the importance of vigilant management, especially when it is associated with any dermatological disorder where the integrity of the skin is compromised. Early diagnosis and prompt treatment are important to avoid mortality. Careful management of underlying dermatoses also helps in preventing recurrence and complications.

Hidradenitis suppurativa (HS) significantly impacts patients' quality of life, particularly in major life-changing decisions (MLCDs) such as career, relationships, and lifestyle. This cross-sectional study involving 50 HS patients identifies critical socio-demographic and clinical factors, such as female sex, disease severity, and missed treatment opportunities, influencing MLCDs. Targeted interventions to mitigate these impacts are crucial for improving patient outcomes.

Entomophthoromycosis, a rare subset of chronic subcutaneous fungal infection caused by Conidiobolus coronatus and Basidiobolus ranarum. It predominantly affects immunocompetent individuals, mostly men. It is typically seen in tropical countries. These case reports describe two male patients a 52-year-old and a 45-year-old from eastern India with a one-year history of rhino facial swelling, initially posing a diagnostic challenge. The skin biopsy revealed granulomas, multinucleated giant cells, and a positive Splendore-Hoeppli phenomenon, supported by MRI findings indicating soft tissue thickening and enhancement confirming the diagnosis. Both the patients were successfully managed with oral itraconazole and supersaturated potassium iodide which highlighted the importance of a comprehensive diagnostic approach and appropriate antifungal therapy.

Background: Skin diseases affect a significant portion of the population, with potentially severe consequences on physical and psychosocial well-being. However, skin disorders are often overlooked in healthcare discussions and funding allocation, despite their substantial impact on patients' lives.

Aims and objectives: The objective of this study was to investigate the psychosocial and psychiatric impact of chronic dermatological disorders among patients. Additionally, the study examined how various factors, such as age, gender, disease severity and socioeconomic status, influence the impact of dermatological disorders on psychosocial well-being.

Materials and methods: This cross-sectional study was conducted in Ahmedabad, India, from August 2022 to 2023. A total of 244 patients with chronic dermatological disorders, aged 12 to 75 years, were included in the study. Trained dermatologists diagnosed the skin conditions, and participants provided written informed consent. Data were collected using a pre-designed questionnaire covering demographic information, disease characteristics and psychosocial factors. The Dermatology Life Quality Index (DLQI) was used to assess quality of life (QoL), and the General Health Questionnaire-28 (GHQ-28) measured psychiatric morbidity. Descriptive analysis, analysis of variance (ANOVA), t-tests and Chi-square tests were performed for data analysis using Jamovi 2.3.21.

Results: Among the 244 participants, the majority were male (130, 53.27%), aged 26 to 50 years (124, 50.81%), married (140, 57.38%) and educated (208, 85.25%). Most patients were Hindu (201, 82.38%) and were living above the poverty line (81, 66.80%). Chronic skin conditions were predominantly non-infective (175, 71.72%), with a significant impact on QoL. The DLQI revealed that 95.08% (232) of patients experienced varying degrees of psychosocial impact. The GHQ-28 identified psychiatric morbidity in 41.80% (102) of patients, with atypical distress being the most common (28.43%). Disease severity, disease location, duration and body surface area involvement significantly influenced the psychosocial impact and psychiatric morbidity.

Conclusion: Chronic skin disorders significantly impact patients' QoL, raising the risk of psychiatric issues. Disease factors, such as severity and location, play a vital role. Addressing psychosocial aspects is crucial.