Balachandra S Ankad,Balkrishna P Nikam,Eshritha Chigurupati
{"title":"Dermoscopy of Familial Gigantic Melanocytosis: A Report of Rare Entity.","authors":"Balachandra S Ankad,Balkrishna P Nikam,Eshritha Chigurupati","doi":"10.4103/ijd.ijd_313_23","DOIUrl":"https://doi.org/10.4103/ijd.ijd_313_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"40 1","pages":"359-361"},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Porokeratosis (PK) is a chronic progressive disorder of keratinization characterized clinically by hyperkeratotic papules or plaques surrounded by a threadlike, elevated border that expands centrifugally. Pathogenesis involves heterozygous mutations in mevalonate kinase enzyme. The most common variants are disseminated superficial actinic porokeratosis (DSAP) and PK of Mibelli. All forms show a thin column of parakeratosis, the cornoid lamella, representing the active border. Dermoscopy reveals central brownish discoloration surrounded by a single hypopigmented band and a peripheral ‘white track’. Long-standing cases of PK may undergo malignant transformation. UV-protection and topical agents, such as 5-fluorouracil, imiquimod, calcipotriol, tretinoin and oral retinoids are helpful. To study the clinical and epidemiological pattern of PK and the clinico-dermoscopic and histopathological correlation of PK. A prospective cross-sectional study was conducted on the patients attending the dermatology outpatient department (OPD) over 9 months with suspected features of PK. These patients were evaluated clinically and subjected to dermoscopy and histopathology. Statistical Package for the Social Sciences (SPSS) Of 11 patients, there were four (36.36%) males and seven (63.66%) females. The youngest was 18-year-old boy, and the eldest was 63-year-old man. The clinically most common type was PK of Mibelli with five (45.45%) cases. The most common dermoscopic feature observed was double-marginated, white peripheral border. The most common histopathological feature noted was cornoid lamella. PK is a rare skin disorder with a wide spectrum of clinical variants. Dermoscopy and histopathology aid in diagnosis, whereas dermoscopy plays a pivotal role in early and non-invasive diagnosis. Regular follow-up is mandatory to watch for the development of malignancies in a few variants.
{"title":"A Clinico-Epidemiological Study on Porokeratosis","authors":"Trishala Shirahatti, H Bangaru, S Sathish","doi":"10.4103/ijd.ijd_131_24","DOIUrl":"https://doi.org/10.4103/ijd.ijd_131_24","url":null,"abstract":"<p>Porokeratosis (PK) is a chronic progressive disorder of keratinization characterized clinically by hyperkeratotic papules or plaques surrounded by a threadlike, elevated border that expands centrifugally. Pathogenesis involves heterozygous mutations in mevalonate kinase enzyme. The most common variants are disseminated superficial actinic porokeratosis (DSAP) and PK of Mibelli. All forms show a thin column of parakeratosis, the cornoid lamella, representing the active border. Dermoscopy reveals central brownish discoloration surrounded by a single hypopigmented band and a peripheral ‘white track’. Long-standing cases of PK may undergo malignant transformation. UV-protection and topical agents, such as 5-fluorouracil, imiquimod, calcipotriol, tretinoin and oral retinoids are helpful. To study the clinical and epidemiological pattern of PK and the clinico-dermoscopic and histopathological correlation of PK. A prospective cross-sectional study was conducted on the patients attending the dermatology outpatient department (OPD) over 9 months with suspected features of PK. These patients were evaluated clinically and subjected to dermoscopy and histopathology. Statistical Package for the Social Sciences (SPSS) Of 11 patients, there were four (36.36%) males and seven (63.66%) females. The youngest was 18-year-old boy, and the eldest was 63-year-old man. The clinically most common type was PK of Mibelli with five (45.45%) cases. The most common dermoscopic feature observed was double-marginated, white peripheral border. The most common histopathological feature noted was cornoid lamella. PK is a rare skin disorder with a wide spectrum of clinical variants. Dermoscopy and histopathology aid in diagnosis, whereas dermoscopy plays a pivotal role in early and non-invasive diagnosis. Regular follow-up is mandatory to watch for the development of malignancies in a few variants.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"2 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142205761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tejasvi Dwivedi,Sri Sai Kaumudi Chirumamilla,Jivtesh Singh,Satyaki Ganguly
{"title":"Irritant Contact Dermatitis from Accidental Exposure to a Kitchen Degreaser.","authors":"Tejasvi Dwivedi,Sri Sai Kaumudi Chirumamilla,Jivtesh Singh,Satyaki Ganguly","doi":"10.4103/ijd.ijd_396_23","DOIUrl":"https://doi.org/10.4103/ijd.ijd_396_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"31 1","pages":"354-355"},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Progressive Lipoatrophy due to Lupus Erythematosus Panniculitis Induced by Quadrivalent Human Papillomavirus Vaccine.","authors":"Nao Kawano,Takahiro Shiratori","doi":"10.4103/ijd.ijd_794_23","DOIUrl":"https://doi.org/10.4103/ijd.ijd_794_23","url":null,"abstract":"","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"31 1","pages":"341-342"},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BackgroundRapid diagnosis of melanoma is necessary for a good prognosis. Using teledermatology and artificial intelligence for this issue is developing, but its diagnostic accuracy is less measured in a clinical setting.ObjectiveThe purpose of this study was to assess the diagnostic accuracy of the teledermoscopy method using the FotoFinder device as well as the Moleanalyzer Pro artificial intelligence (AI) Assistant and to compare them with the face-to-face clinical examination for the diagnosis of melanoma confirmed with histopathology.MethodsThirty melanocytic moles of 29 patients were included in the study. Each mole was assessed face-to-face, using FotoFinder teledermoscopy and Moleanalyzer Pro software methods. The results obtained from each method were compared with the results of the gold standard (pathology). The sensitivity and specificity of the three methods were calculated for malignant and borderline versus benign lesions. Inter-method reliability between a gold standard and other methods was evaluated using per cent agreement and Cohen's kappa coefficient.ResultsFive moles had a histopathological diagnosis of melanoma, and six and 19 moles were diagnosed as borderline and benign, respectively. Sensitivities and specificities were, respectively, as follows: face-to-face (90.9%, 57.9%), FotoFinder teledermoscopy (63.6%, 78.9%), FotoFinder® Moleanalyzer Pro (36.4%, 42.1%). Agreement with biopsy-obtained diagnosis categories of benign, borderline and malignant for face-to-face was 63.33%, FotoFinder teledermoscopy 73.33%, and FotoFinder® Moleanalyzer Pro 40%.ConclusionsTeledermoscopy had the highest agreement with reference diagnosis as well as the highest specificities that caused a reduction of biopsy referrals. The FotoFinder® Moleanalyzer Pro had the lowest agreement. Therefore, it cannot replace dermatologist decision making.
背景黑色素瘤的快速诊断对良好的预后至关重要。本研究的目的是评估使用 FotoFinder 设备和 Moleanalyzer Pro 人工智能(AI)助手的皮肤远程镜检查方法的诊断准确性,并将其与经组织病理学确诊的黑色素瘤的面对面临床检查进行比较。采用 FotoFinder teledermoscopy 和 Moleanalyzer Pro 软件方法对每个痣进行面对面评估。每种方法得出的结果都与金标准(病理学)的结果进行了比较。计算了三种方法对恶性病变、边缘性病变和良性病变的敏感性和特异性。结果5颗痣经组织病理学诊断为黑色素瘤,6颗痣和19颗痣分别被诊断为边缘性痣和良性痣。灵敏度和特异度分别为:面对面(90.9%,57.9%)、FotoFinder 远程皮肤镜(63.6%,78.9%)、FotoFinder® Moleanalyzer Pro(36.4%,42.1%)。面对面检查与活组织检查获得的良性、边缘性和恶性诊断类别的一致性为 63.33%,FotoFinder 远程皮肤镜为 73.33%,FotoFinder® Moleanalyzer Pro 为 40%。结论远程皮肤镜与参考诊断的一致性最高,特异性也最高,从而减少了活组织检查的转诊。FotoFinder® Moleanalyzer Pro的一致性最低。因此,它不能取代皮肤科医生的决策。
{"title":"Comparison of the Diagnostic Accuracy of Teledermoscopy, Face-to-Face Examinations and Artificial Intelligence in the Diagnosis of Melanoma.","authors":"Taraneh Yazdanparast,Mansour Shamsipour,Azin Ayatollahi,Shohreh Delavar,Maryam Ahmadi,Aniseh Samadi,Alireza Firooz","doi":"10.4103/ijd.ijd_61_24","DOIUrl":"https://doi.org/10.4103/ijd.ijd_61_24","url":null,"abstract":"BackgroundRapid diagnosis of melanoma is necessary for a good prognosis. Using teledermatology and artificial intelligence for this issue is developing, but its diagnostic accuracy is less measured in a clinical setting.ObjectiveThe purpose of this study was to assess the diagnostic accuracy of the teledermoscopy method using the FotoFinder device as well as the Moleanalyzer Pro artificial intelligence (AI) Assistant and to compare them with the face-to-face clinical examination for the diagnosis of melanoma confirmed with histopathology.MethodsThirty melanocytic moles of 29 patients were included in the study. Each mole was assessed face-to-face, using FotoFinder teledermoscopy and Moleanalyzer Pro software methods. The results obtained from each method were compared with the results of the gold standard (pathology). The sensitivity and specificity of the three methods were calculated for malignant and borderline versus benign lesions. Inter-method reliability between a gold standard and other methods was evaluated using per cent agreement and Cohen's kappa coefficient.ResultsFive moles had a histopathological diagnosis of melanoma, and six and 19 moles were diagnosed as borderline and benign, respectively. Sensitivities and specificities were, respectively, as follows: face-to-face (90.9%, 57.9%), FotoFinder teledermoscopy (63.6%, 78.9%), FotoFinder® Moleanalyzer Pro (36.4%, 42.1%). Agreement with biopsy-obtained diagnosis categories of benign, borderline and malignant for face-to-face was 63.33%, FotoFinder teledermoscopy 73.33%, and FotoFinder® Moleanalyzer Pro 40%.ConclusionsTeledermoscopy had the highest agreement with reference diagnosis as well as the highest specificities that caused a reduction of biopsy referrals. The FotoFinder® Moleanalyzer Pro had the lowest agreement. Therefore, it cannot replace dermatologist decision making.","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"37 1","pages":"296-300"},"PeriodicalIF":1.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rash and fever are some of the most common chief complaints present in paediatric dermatology emergencies. The spectrum of differential diagnosis is broad, including many different infectious and some non-infectious agents. A systematic approach involving detailed history taking, careful clinical examination along with particular attention to epidemiological features are the most important factors to make a diagnosis. This article reviews the morphological patterns of various causes of fever with rash in children, including infectious as well as non-infectious causes, with special emphasis on the Indian scenario. We intend to highlight the clinical characteristics of each cause, which will not only help make a clinical diagnosis but also distinguish benign versus life-threatening causes of skin rash in febrile paediatric patients and provide early medical intervention.
{"title":"Fever with Rash in a Child: Revisited","authors":"Rashmi Sarkar, Anukriti Yadav, Apoorva Maheshwari","doi":"10.4103/ijd.ijd_913_23","DOIUrl":"https://doi.org/10.4103/ijd.ijd_913_23","url":null,"abstract":"<p>Rash and fever are some of the most common chief complaints present in paediatric dermatology emergencies. The spectrum of differential diagnosis is broad, including many different infectious and some non-infectious agents. A systematic approach involving detailed history taking, careful clinical examination along with particular attention to epidemiological features are the most important factors to make a diagnosis. This article reviews the morphological patterns of various causes of fever with rash in children, including infectious as well as non-infectious causes, with special emphasis on the Indian scenario. We intend to highlight the clinical characteristics of each cause, which will not only help make a clinical diagnosis but also distinguish benign versus life-threatening causes of skin rash in febrile paediatric patients and provide early medical intervention.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"11 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141516036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shrichand G. Parasramani, Bikash R. Kar, Sushil Tahiliani, Anchala Parthasarathi, Shekhar Neema, Satyaki Ganguly, Dharshini Sathishkumar, K Venkatachalam, Haritha Komeravelli, Jayakar Thomas
Pustular psoriasis is a specialized variant of psoriasis which can be life threatening if not treated at the earliest. The pathogenesis has been recently linked to the role of interleukin 36. Apart from the corticosteroids, systemic antipsoriatics like acitretin, cyclosporine and methotrexate have been used with some success though unpredictable. With recent identification of role of IL-36 in the pathogenesis of pustular psoriasis, biologics targeting the IL-36 receptors have been used to manage the situation with high degree of success. This narrative review deals with the recent concepts of pathogenesis of pustular psoriasis as well as the current management scenario.
{"title":"Management of Pustular Psoriasis; The Way Ahead","authors":"Shrichand G. Parasramani, Bikash R. Kar, Sushil Tahiliani, Anchala Parthasarathi, Shekhar Neema, Satyaki Ganguly, Dharshini Sathishkumar, K Venkatachalam, Haritha Komeravelli, Jayakar Thomas","doi":"10.4103/ijd.ijd_165_24","DOIUrl":"https://doi.org/10.4103/ijd.ijd_165_24","url":null,"abstract":"<p>Pustular psoriasis is a specialized variant of psoriasis which can be life threatening if not treated at the earliest. The pathogenesis has been recently linked to the role of interleukin 36. Apart from the corticosteroids, systemic antipsoriatics like acitretin, cyclosporine and methotrexate have been used with some success though unpredictable. With recent identification of role of IL-36 in the pathogenesis of pustular psoriasis, biologics targeting the IL-36 receptors have been used to manage the situation with high degree of success. This narrative review deals with the recent concepts of pathogenesis of pustular psoriasis as well as the current management scenario.</p>","PeriodicalId":13401,"journal":{"name":"Indian Journal of Dermatology","volume":"14 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141530887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}