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May–Hegglin anomaly: A rare hereditary autoimmune thrombocytopenia May-Hegglin异常:罕见的遗传性自身免疫性血小板减少症
Pub Date : 2023-05-01 DOI: 10.4103/kleuhsj.kleuhsj_567_22
Vinaya A. Singh, M. Khan, S. Malik, Poonam Wade, V. Kulkarni
Neonatal thrombocytopenia is a common entity encountered in neonatal intensive care unit. Diagnosis often becomes challenging because of broad range of possible clinical diagnoses. Careful evaluation and history taking are the backbone of sound diagnosis. During such diagnostic dilemma, investigation as basic as peripheral smear examination can come to a rescue. Here, we present a rare case of neonatal autoimmune thrombocytopenia. On the basis of detailed history, careful examination, and basic investigations, diagnosis of May–Hegglin anomaly was made which was later confirmed by genetic studies (rare mutation in myosin heavy chain 9 gene).
新生儿血小板减少症是新生儿重症监护病房常见的疾病。由于可能的临床诊断范围广泛,诊断往往变得具有挑战性。仔细的评估和病史记录是正确诊断的基础。在这种诊断困境中,像外周涂片检查这样的基本调查可以起到拯救作用。在此,我们报告一例罕见的新生儿自身免疫性血小板减少症。在详细病史、仔细检查和基础调查的基础上,诊断为May-Hegglin异常,并经遗传学研究证实(肌球蛋白重链9基因罕见突变)。
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引用次数: 0
Outcome of management of patients with BPH and vesical calculi BPH合并膀胱结石患者的治疗结果
Pub Date : 2023-05-01 DOI: 10.4103/kleuhsj.kleuhsj_101_22
R. Nerli, Keyur Patel, S. Rai, S. Rangrez, Neeraj S. Dixit
INTRODUCTION: The complications of benign prostatic hyperplasia (BPH) among others include bladder stones. The prevalence of vesical calculus is eight times higher in men having BPH (3.4%) as compared with men without BPH (0.4%). The guidelines suggest that BPH obstruction should be managed along with removal of bladder stones. The objective of the study was to study the outcome of surgery in patients with BPH and bladder calculi. MATERIALS AND METHODS: This prospective study included all patients undergoing surgical treatment for BPH with vesical calculi. Outcomes were measured in terms of blood loss, operating time, days of hospitalization, postoperative urinary flow, postvoid residual, and complications. RESULTS: Five (13.51%) patients underwent perurethral cystolitholapaxy, 17 (45.94%) underwent percutaneous suprapubic cystolitholapaxy, and the remaining 15 (40.54%) underwent open cystolithotomy for bladder stones. The prostate (BPH) was managed by monopolar transurethral resection of prostate (TURP) in 14 (37.83%), bipolar TURP in 12 (32.43%), and laser prostatectomy (Holmium enucleation) in the remaining 11 (29.72%). At the time of discharge, all patients were free of bladder stones and voided well. At 3-month follow-up, the mean Q-max was 18.65 mL/s. CONCLUSIONS: Simultaneous management of BPH and bladder stones is safe and effective. The procedure chosen for managing bladder stones depends on the size, number, and experience of the surgeon. Smaller stones can be easily managed by minimally invasive procedures such as perurethral cystolitholapaxy and percutaneous cystolitholapaxy.
简介:良性前列腺增生(BPH)的并发症包括膀胱结石。膀胱结石在前列腺增生男性中的患病率(3.4%)是无前列腺增生男性患病率(0.4%)的8倍。指南建议BPH梗阻应与膀胱结石切除同时处理。该研究的目的是研究前列腺增生和膀胱结石患者的手术结果。材料和方法:这项前瞻性研究包括所有接受前列腺增生伴膀胱结石手术治疗的患者。根据出血量、手术时间、住院天数、术后尿流、空隙后残留和并发症来衡量结果。结果:经尿道膀胱取石术5例(13.51%),经皮耻骨上膀胱取石术17例(45.94%),开放性膀胱取石术15例(40.54%)。单极经尿道前列腺切除术(TURP) 14例(37.83%),双极经尿道前列腺切除术(TURP) 12例(32.43%),激光前列腺切除术(钬去核)11例(29.72%)。出院时,所有患者均无膀胱结石,排尿良好。随访3个月时,平均Q-max为18.65 mL/s。结论:前列腺增生与膀胱结石同时治疗是安全有效的。治疗膀胱结石的方法取决于膀胱结石的大小、数量和外科医生的经验。较小的结石可以很容易地通过微创手术,如经尿道膀胱石固定术和经皮膀胱石固定术。
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引用次数: 0
Maternal and neonatal determinants of perinatal mortality in selected tertiary care hospital of North Karnataka 在北卡纳塔克邦选定的三级保健医院中,孕产妇和新生儿围产期死亡率的决定因素
Pub Date : 2023-05-01 DOI: 10.4103/kleuhsj.kleuhsj_493_22
Uma Kole, Sudha A. Raddi, A. Dalal
INTRODUCTION: Goal 3 of sustainable development aims to ensure healthy lives and promote well-being for all people of all ages. One of the components for achieving this objective is the improvement of maternal and child health, with the perinatal mortality (PM) rate serving as an indicator. This study aimed to know the probable cause of perinatal death at a medical center of tertiary care to reduce the incidence of perinatal death and enhance the quality of care. OBJECTIVE: The objective of this study was to study the incidence and associated risk factors of PM in a selected tertiary care hospital. MATERIALS AND METHODS: A prospective case series study was conducted from August 2019 to September 2021 among all pregnant mothers who delivered in selected tertiary care hospitals of Belagavi city among 3508 participants. RESULTS: In the present study, results revealed that 29 per 1000 births and 7.12 per 1000 live births of END. The incidence of PM was 36.48 per 1000 births in the present study. There was a positive correlation between maternal weight in kg versus the birth weight of the baby (R = 0.091, P < 0.001). Results inferred that maternal anemia, antepartum hemorrhage, hypertensive disorders, thyroid disorders, amniotic fluid infections, and placental insufficiency were identified as primary causes of stillbirth. CONCLUSION: There is a region-wise wide variation in the rate of PM. There was an inverse relationship between birth weight and stillbirth, neonatal death, and perinatal death rate. Low birth weight babies contributed more than three times to stillbirths, early neonatal deaths, and perinatal deaths as compared to babies with normal birth weight.
导言:可持续发展目标3旨在确保健康的生活方式,促进各年龄段所有人的福祉。实现这一目标的组成部分之一是改善孕产妇和儿童健康,围产期死亡率是一项指标。本研究旨在了解三级医疗中心围产期死亡的可能原因,以降低围产期死亡发生率,提高护理质量。目的:本研究的目的是研究在选定的三级保健医院PM的发病率和相关危险因素。材料与方法:2019年8月至2021年9月,在贝拉加维市选定的三级医院分娩的所有孕妇中,对3508名参与者进行了前瞻性病例系列研究。结果:在本研究中,结果显示,每1000个新生儿中有29个,每1000个活产婴儿中有7.12个。在本研究中,PM的发病率为36.48 / 1000。产妇体重(kg)与婴儿出生体重呈正相关(R = 0.091, P < 0.001)。结果表明,产妇贫血、产前出血、高血压疾病、甲状腺疾病、羊水感染和胎盘功能不全是导致死产的主要原因。结论:不同地区PM率存在较大差异。出生体重与死产、新生儿死亡和围产期死亡率呈负相关。与正常出生体重的婴儿相比,低出生体重婴儿对死产、新生儿早期死亡和围产期死亡的贡献是正常出生体重婴儿的三倍多。
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引用次数: 0
Fibrolipoma of the buccal mucosa: A rare case report 口腔黏膜纤维脂肪瘤1例
Pub Date : 2023-01-01 DOI: 10.4103/kleuhsj.kleuhsj_580_22
D. Keerthana, P. Angadi
Fibrolipoma is a benign neoplasm categorized as a histopathological variant of classical lipoma. The occurrence of fibrolipoma in the oral cavity is extremely rare. When present, it manifests as a pedunculated or sessile, soft, smooth-surfaced nodular mass. Although it may vary, the majority of lesions are <5 cm in size. There may be association between functional and aesthetic limitations related to anatomical sites. Hence, it is crucial to properly examine lipomas histopathologically for better treatment modalities. Here is a case report of fibrolipoma occurring in buccal mucosa.
纤维脂肪瘤是一种良性肿瘤,是典型脂肪瘤的一种组织病理学变异。摘要纤维脂肪瘤在口腔的发生极为罕见。当它出现时,表现为有梗或无梗,柔软,表面光滑的结节状肿块。虽然可能有所不同,但大多数病变的大小小于5cm。与解剖部位有关的功能和美学限制之间可能存在关联。因此,对脂肪瘤进行组织病理学检查以获得更好的治疗方法是至关重要的。本文报告一例发生于口腔黏膜的纤维脂肪瘤。
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引用次数: 0
Echocardiographic assessment of the right ventricular function in acute myocardial infarction 超声心动图评价急性心肌梗死右心室功能
Pub Date : 2023-01-01 DOI: 10.4103/kleuhsj.kleuhsj_337_21
S. Lohitashwa, Srinidhi S. Hegde, K. Varghese, M. Srilakshmi, Sreekantha Sudaraghavan
Background: Assessment of the right chamber function has not given much importance; this could be due to complex structure, asymmetric shape, and difficulty in visualization, and resulted in poor understanding of the impact of the right ventricular (RV) function on prognosis. Echocardiography commonly used and most readily available investigation modality for the assessment of the right ventricular function. AIMS AND OBJECTIVES: The aim of this study was to evaluate the relation between RV function and left ventricle (LV) dysfunction and Killip class in acute myocardial infarction (AMI) exclusive of RV infarction. MATERIAL AND METHODS: A total of 21 consecutive patients admitted to the coronary care unit with AMI were included and echocardiography was performed within 24 h of admission to assess RV and LV functions. RV function was quantified with a tricuspid annular plane systolic excursion (TAPSE), RV fractional area change (RVFAC), RV longitudinal strain, RV myocardial performance index (RVMPI), and compared with the LV ejection fraction and Killip class. Results: Statistical analysis revealed that the majority of patients were male (90.5%) and only 9.5% of patients were female with a mean age of 50.9 years. Anterior wall MI was more common (58%) than inferior wall MI (42%). The study findings revealed that the RV longitudinal strain had a significant negative correlation (r2 = 0.803, P = 0.001) with Killip class and LV ejection fraction, whereas TAPSE, RVMPI, and RVFAC were poorly correlated with RV dysfunction. Conclusion: From the study findings, we concluded that echocardiographic assessment of RV functions demonstrated that larger infarcts correlated with RV dysfunction. RV involvement was more pronounced in anterior MI than inferior MI. Hence, the earliest recognition of RV dysfunction is warranted. Keywords: Acute myocardial infarction, echocardiograph, right ventricular function.
背景:对右心室功能的评估尚未得到重视;这可能是由于右心室结构复杂,形状不对称,难以可视化,导致对右心室(RV)功能对预后的影响了解不足。超声心动图是评估右心室功能最常用和最容易获得的调查方式。目的和目的:本研究的目的是评估急性心肌梗死(AMI)患者左心室功能与左心室功能障碍和Killip分级之间的关系。材料和方法:共纳入21例连续入住冠状动脉护理病房的AMI患者,并在入院24小时内进行超声心动图检查以评估左室和左室功能。采用三尖瓣环平面收缩偏移(TAPSE)、左室分数面积变化(RVFAC)、左室纵向应变、左室心肌功能指数(RVMPI)量化左室功能,并与左室射血分数和Killip分级进行比较。结果:统计分析显示,男性占90.5%,女性占9.5%,平均年龄50.9岁。前壁心肌梗死(58%)比下壁心肌梗死(42%)更为常见。研究结果显示,左室纵向应变与Killip分级和左室射血分数呈显著负相关(r2 = 0.803, P = 0.001),而TAPSE、RVMPI和RVFAC与右室功能障碍相关性较差。结论:从研究结果中,我们得出结论,超声心动图对右心室功能的评估表明,较大的梗死与右心室功能障碍相关。左心室受累在心肌梗死前段比下段更为明显。因此,早期识别右心室功能障碍是有必要的。关键词:急性心肌梗死,超声心动图,右心室功能。
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引用次数: 0
HIV/acquired immune deficiency syndrome stigma, perceived social support, and medical adherence among HIV/acquired immune deficiency syndrome children: A mediation analysis 艾滋病毒/获得性免疫缺陷综合征儿童的耻辱感、感知的社会支持和医疗依从性:中介分析
Pub Date : 2023-01-01 DOI: 10.4103/kleuhsj.kleuhsj_128_22
Swaran Lata, Varsha Singh, Anupriya
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引用次数: 0
A study of dermatophytosis in patients attending dermatology outdoor patient department at a tertiary care center 在三级保健中心皮肤科室外病人部就诊的患者的皮肤癣的研究
Pub Date : 2023-01-01 DOI: 10.4103/kleuhsj.kleuhsj_152_22
Milind Ubale, V. Nanoty, P. Patel, RajeshMahadeo Trimukhe, DebapriyaDas Choudhury, Pradnya S. Joshi
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引用次数: 0
Influence of social media in research: Boon or bane 社交媒体在研究中的影响:是福还是祸
Pub Date : 2023-01-01 DOI: 10.4103/kleuhsj.kleuhsj_82_23
P. Angadi, H. Kour
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引用次数: 1
Rare presentation of localized gingival overgrowth with osseous defect – Case report 罕见的局部牙龈过度生长伴骨缺损1例
Pub Date : 2023-01-01 DOI: 10.4103/kleuhsj.kleuhsj_492_22
Ruchi Srivastava, Anju Gautam
Gingival overgrowth is one of the most undesirable consequences that often lead to impaired esthetics and masticatory functions, compromised oral hygiene maintenance often requiring surgical excision of the excessive tissue. Gingival overgrowth belongs to a common group of lesions designated as focal reactive overgrowths. These growths are reactive in nature. A definitive diagnosis will then enable an appropriate management strategy. Peripheral giant-cell granuloma (PGCG) is a reactive focal overgrowth, ordinarily presents as an epulis-like growth. This is of a reactive rather than neoplastic nature and its pathogenesis is uncertain. It is widely considered to originate from the cells of the periodontal ligament, occurring as a response to irritants such as dental calculus, plaque, microorganisms, dental appliances, and restorations. The purpose of this article is to report the clinical, histopathological features and treatment of a case with PGCG arising from mandibular posterior alveolus in a 34-year-old female. The overgrowth was well defined along with the bone defect, involving the buccal aspect of the mandibular gingiva. The tooth was endodontically treated, the lesion was completely excised, and the osseous defect was filled with regenerative material. The 12-month follow-up radiograph revealed successful healing with no more recurrence.
牙龈过度生长是最不受欢迎的后果之一,通常会导致美学和咀嚼功能受损,损害口腔卫生维护,通常需要手术切除多余的组织。牙龈过度生长属于一组常见的病变,称为局灶性反应性过度生长。这些生长本质上是反应性的。明确的诊断将使适当的管理策略成为可能。外周巨细胞肉芽肿(PGCG)是一种反应性局灶性过度增生,通常表现为脓肿样生长。这是一种反应性而非肿瘤性质,其发病机制尚不清楚。人们普遍认为它起源于牙周韧带的细胞,是对牙石、牙菌斑、微生物、牙科器械和修复体等刺激物的反应。本文的目的是报告一例34岁女性下颌骨后牙槽产生的PGCG的临床,组织病理学特征和治疗。生长过度和骨缺损都很清楚,包括下颌牙龈的颊面。牙髓内治疗,病变完全切除,骨缺损用再生材料填充。12个月的随访x线片显示成功愈合,无复发。
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引用次数: 0
Repeatability of arterial pulse-based diagnosis (Naadi pariksha) by test–retest method: An observation study 动脉脉搏诊断(Naadi pariksha)复测法的重复性观察研究
Pub Date : 2023-01-01 DOI: 10.4103/kleuhsj.kleuhsj_398_21
UsharaniS Sanu, B. Prasad, R. Hiremath, Sunil S. Vernekar
INTRODUCTION: Naadi pariksha is a historical diagnostic skill of physicians to examine the state of dosha (dosha avasta) in patients. Although this is a commonly used examination, there is still a need for standardization in the collection of data and reliability of the diagnostic technique. Considerable researchers have been conducted on the pulse classification based on its characters but this study was conducted to analyze the repeatability of arterial pulse-based diagnosis (Naadi pariksha) by test–retest method in a single group. AIM: The study aims to test and retest the repeatability of the arterial pulse-based diagnosis. The naadi parameters such as pulse wavelength and pulse character were tested for repeatability in the gap period of 9–18 min in a controlled environment. MATERIALS AND METHODS: This was an observational study conducted in Belagavi. An Ayurveda physician examined the pulse of 30 healthy volunteers twice, within an interval of 9–18 min. A random sampling of volunteers was adopted (to avoid bias), and the data were recorded graphically as per the study protocol. This study was conducted for 6 days with five participants per day for examination. The Naadi pariksha was done to examine the pulse wavelength and pulse character. The data obtained from the test and retest of Naadi pariksha were statistically analyzed using paired t-test to study the difference between both the test–retest methods. RESULTS: All the data collected from the naadi examination were statistically analyzed using IBM SPSS Statistics 26. The mean difference in pulse wavelength was 0.004 mm (standard deviation [SD]: 0.2067 mm, degree of freedom (df): 29, and t: 0.106). There was no statistically significant difference between the two variables: test and retest pulse wavelength (P > 0.05). The mean difference in pulse character was 0.333 mm (SD: 1.64177 mm, df: 29, and t value: 1.112). There was no statistically significant difference between the two variables: test and retest pulse wavelength (P > 0.05). CONCLUSION: The reliability and repeatability of pulse-based diagnosis depend on the adaptation of standardized techniques in arterial pulse data collection along with the training, maintaining the controlled environment, and experience of a physician in naadi pariksha. Quantification of the physiological signals has become more important to create evidence and research documentation. The results of this study suggest that an identical report may be obtained on repetition of the test within 9–18 min. This demonstrates the repeatability of arterial pulse-based diagnosis (naadi pariksha).
Naadi pariksha是一种历史诊断技能,用于医生检查患者的dosha状态(dosha avasta)。虽然这是一种常用的检查,但在数据收集和诊断技术的可靠性方面仍然需要标准化。基于脉搏特征的脉搏分类已经有相当多的研究,但本研究是为了分析单组动脉脉搏诊断(Naadi pariksha)的复试方法的可重复性。目的:本研究旨在验证动脉脉搏诊断的可重复性。在受控环境下,对脉冲波长和脉冲特性等naadi参数进行了9 ~ 18 min间隙期的重复性测试。材料与方法:这是一项在Belagavi进行的观察性研究。一位阿育吠陀医生在9-18分钟的间隔内对30名健康志愿者的脉搏进行了两次检查。采用随机抽样的方式(为了避免偏差),并根据研究方案以图形方式记录数据。本研究为期6天,每天5名受试者接受检查。Naadi pariksha是用来检测脉冲波长和脉冲特性的。采用配对t检验对Naadi pariksha检验和重测数据进行统计学分析,研究两种重测方法的差异。结果:所有naadi检查数据均采用IBM SPSS Statistics 26进行统计学分析。脉冲波长的平均差值为0.004 mm(标准差[SD]: 0.2067 mm,自由度(df): 29, t: 0.106)。检验与复验脉冲波长两个变量间差异无统计学意义(P > 0.05)。脉冲特征的平均差值为0.333 mm (SD: 1.64177 mm, df: 29, t值:1.112)。检验与复验脉冲波长两个变量间差异无统计学意义(P > 0.05)。结论:脉搏诊断的可靠性和可重复性取决于动脉脉搏数据采集的标准化技术的适应,以及naadi pariksha医生的培训、控制环境的维护和经验。生理信号的量化对于创造证据和研究文献变得更加重要。这项研究的结果表明,在9-18分钟内重复测试可以获得相同的报告。这证明了动脉脉冲诊断的可重复性(naadi pariksha)。
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引用次数: 0
期刊
Indian Journal of Health Sciences and Biomedical Research (KLEU)
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