Pub Date : 2023-09-01DOI: 10.4103/kleuhsj.kleuhsj_364_23
Ramyani Sinha, P. Angadi
OBJECTIVES: About 90% of oral cancers are oral squamous cell carcinomas (OSCC) whose appropriate treatment requires early diagnosis, based on knowledge about biomarkers which are expressed during the complex process of carcinogenesis. Growth differentiation factor-15 (GDF-15) has been considered an important serum and immunohistochemical marker in several cancers. Saliva has several advantages as a diagnostic biofluid. This research intends to evaluate the salivary GDF-15 levels in oral leukoplakia (OL) and in OSCC. MATERIALS AND METHODS: We estimated and compared levels of salivary GDF-15 in cases of OL, OSCC, and healthy controls. Study groups comprised 30 cases each of OL and OSCC. Control group comprised 30 healthy individuals. Saliva samples were assessed using the enzyme-Linked immunosorbent assay for GDF-15 levels. RESULTS: Salivary GDF-15 levels showed a gradual increase from healthy volunteers to cases of OL and highest GDF-15 levels were noted in OSCC group. Increase in concentration of GDF-15 was also noted with increasing grades of OSCC. CONCLUSION: Increased level of GDF-15 in premalignant cases reflects its antitumorigenic role, whereas its expression in later stages of OSCC demonstrates its protumorigenic role. The regulatory mechanism associated with GDF-15 may help in developing some novel therapeutic strategies based on its expression.
{"title":"Salivary growth differentiation factor-15 levels in oral leukoplakia and oral squamous cell carcinoma","authors":"Ramyani Sinha, P. Angadi","doi":"10.4103/kleuhsj.kleuhsj_364_23","DOIUrl":"https://doi.org/10.4103/kleuhsj.kleuhsj_364_23","url":null,"abstract":"OBJECTIVES: About 90% of oral cancers are oral squamous cell carcinomas (OSCC) whose appropriate treatment requires early diagnosis, based on knowledge about biomarkers which are expressed during the complex process of carcinogenesis. Growth differentiation factor-15 (GDF-15) has been considered an important serum and immunohistochemical marker in several cancers. Saliva has several advantages as a diagnostic biofluid. This research intends to evaluate the salivary GDF-15 levels in oral leukoplakia (OL) and in OSCC. MATERIALS AND METHODS: We estimated and compared levels of salivary GDF-15 in cases of OL, OSCC, and healthy controls. Study groups comprised 30 cases each of OL and OSCC. Control group comprised 30 healthy individuals. Saliva samples were assessed using the enzyme-Linked immunosorbent assay for GDF-15 levels. RESULTS: Salivary GDF-15 levels showed a gradual increase from healthy volunteers to cases of OL and highest GDF-15 levels were noted in OSCC group. Increase in concentration of GDF-15 was also noted with increasing grades of OSCC. CONCLUSION: Increased level of GDF-15 in premalignant cases reflects its antitumorigenic role, whereas its expression in later stages of OSCC demonstrates its protumorigenic role. The regulatory mechanism associated with GDF-15 may help in developing some novel therapeutic strategies based on its expression.","PeriodicalId":13457,"journal":{"name":"Indian Journal of Health Sciences and Biomedical Research (KLEU)","volume":"44 1","pages":"391 - 396"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.4103/kleuhsj.kleuhsj_158_23
R. Kore, Shrishail M. Ghurghure, Manish Kondawar
BACKGROUND: DNA fingerprinting is a Special technique used to determine the probable identity of a person based on the nucleotide sequences of certain regions of Plant DNA that are unique to individuals. AIMS AND OBJECTIVES: In this study, the random amplified polymorphic deoxyribonucleic acid (RAPD) technique was employed for the determination of the components in Ayurvedic herbal medicine. The RAPD approach is appealing to a large number of scientists since it may be implemented in a variety of settings with little effort. Most importantly, RAPD analysis does not require any cloning, sequencing, or other molecular characterization of the genome to extract a large number of genetic markers from a small amount of deoxyribonucleic acid (DNA). MATERIALS AND METHODS: Fresh leaves of the Thevetia peruviana (Pers.) Roxb plants were gathered in the month of June in the surroundings of Solapur. RESULTS: We used OPAB11, OPT12, OPQ15, and OPC104 decamer primers to conduct an RAPD study that measures genetic variation at random. Pure and RNA free high molecular weight DNA was extracted from the leaves. CONCLUSION: The DNA was amplified with repeat primers and 4 polymerase chain reaction primers, and then analyzed on agarose gels. Other wild T. peruviana species might be easier to track down with this method.
{"title":"Molecular authentication of Thevetia peruviana (pers.) roxb plant by random amplified polymorphic deoxyribonucleic acid – Barcoding technique","authors":"R. Kore, Shrishail M. Ghurghure, Manish Kondawar","doi":"10.4103/kleuhsj.kleuhsj_158_23","DOIUrl":"https://doi.org/10.4103/kleuhsj.kleuhsj_158_23","url":null,"abstract":"BACKGROUND: DNA fingerprinting is a Special technique used to determine the probable identity of a person based on the nucleotide sequences of certain regions of Plant DNA that are unique to individuals. AIMS AND OBJECTIVES: In this study, the random amplified polymorphic deoxyribonucleic acid (RAPD) technique was employed for the determination of the components in Ayurvedic herbal medicine. The RAPD approach is appealing to a large number of scientists since it may be implemented in a variety of settings with little effort. Most importantly, RAPD analysis does not require any cloning, sequencing, or other molecular characterization of the genome to extract a large number of genetic markers from a small amount of deoxyribonucleic acid (DNA). MATERIALS AND METHODS: Fresh leaves of the Thevetia peruviana (Pers.) Roxb plants were gathered in the month of June in the surroundings of Solapur. RESULTS: We used OPAB11, OPT12, OPQ15, and OPC104 decamer primers to conduct an RAPD study that measures genetic variation at random. Pure and RNA free high molecular weight DNA was extracted from the leaves. CONCLUSION: The DNA was amplified with repeat primers and 4 polymerase chain reaction primers, and then analyzed on agarose gels. Other wild T. peruviana species might be easier to track down with this method.","PeriodicalId":13457,"journal":{"name":"Indian Journal of Health Sciences and Biomedical Research (KLEU)","volume":"26 1","pages":"414 - 417"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.4103/kleuhsj.kleuhsj_295_23
Saurabh Ram Bihari Shrivastava, P. Shrivastava
Humanitarian emergencies such as man-made conflicts tend to influence and impact every aspect of human lives, including medical education. Humanitarian emergencies accounts for far-reaching consequences in the domain of medical education, including disruption of educational infrastructure (viz. medical school and training facilities) that significantly hampers the delivery of medical education. There is an immense need to plan and prepare for these humanitarian emergencies and thereby implement appropriate measures to ensure that delivery of medical education is not disturbed. To conclude, humanitarian emergencies have become quite common in today's era. However, as the impact of these emergencies on medical education is multi-fold, there is an immense need to address the problem. In-fact, the need of the hour is to plan and implement a multi-pronged approach to ensure that despite the challenges posed by humanitarian emergencies, we are well-equipped to ensure medical education delivery.
{"title":"Medical education and Humanitarian emergencies: Necessity to strengthen","authors":"Saurabh Ram Bihari Shrivastava, P. Shrivastava","doi":"10.4103/kleuhsj.kleuhsj_295_23","DOIUrl":"https://doi.org/10.4103/kleuhsj.kleuhsj_295_23","url":null,"abstract":"Humanitarian emergencies such as man-made conflicts tend to influence and impact every aspect of human lives, including medical education. Humanitarian emergencies accounts for far-reaching consequences in the domain of medical education, including disruption of educational infrastructure (viz. medical school and training facilities) that significantly hampers the delivery of medical education. There is an immense need to plan and prepare for these humanitarian emergencies and thereby implement appropriate measures to ensure that delivery of medical education is not disturbed. To conclude, humanitarian emergencies have become quite common in today's era. However, as the impact of these emergencies on medical education is multi-fold, there is an immense need to address the problem. In-fact, the need of the hour is to plan and implement a multi-pronged approach to ensure that despite the challenges posed by humanitarian emergencies, we are well-equipped to ensure medical education delivery.","PeriodicalId":13457,"journal":{"name":"Indian Journal of Health Sciences and Biomedical Research (KLEU)","volume":"68 1","pages":"432 - 434"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.4103/kleuhsj.kleuhsj_219_23
Saurabh Sharma, Paran Joshi, Raman Grover
BACKGROUND: Palate has been a topic of interest regarding sex determination from human skeletal remains in physical anthropology. Palatal index (PI) is an important parameter for the sex determination of deceased individuals with unknown identity. AIM: The study aimed to determine and compare PI, clinically and radiographically, and evaluate its role in sexual dimorphism in the Central Indian population. MATERIALS AND METHODS: This study was conducted on 392 participants, in the department of anatomy and dentistry of a premium medical college in India. Maxillary casts were used for clinical measurement. Posteroanterior and lateral cephalogram (Ceph) were used for the radiographic method. Palatal length (PL) and palatal breadth (PB) were measured. PI was calculated as PB/PL × 100. Data were analyzed using unpaired Student's t-test. RESULTS: Participants belonged to the age group of 41–50 years (31.63%), 51–60 years (27.04%), and 18–30 years (18.87%). Clinical and radiographic PB was found to be higher in males (37.94 ± 1.28 mm, 38.87 ± 3.11 mm) than females (35.44 ± 1.18 mm, 36.62 ± 2.75 mm). PL demonstrated almost similar clinical values in males (45.25 ± 1.65 mm) and females (45.21 ± 1.51 mm) with no statistical significance. Radiographic PL was significantly higher in males (48.28 ± 1.60 mm) than females (46.41 ± 1.69 mm). Males demonstrated higher PI, clinically and radiographically (83.84 ± 3.82 mm, 80.51 ± 5.32 mm), than females (78.38 ± 4.19 mm, 78.91 ± 5.06 mm). CONCLUSION: Palatal parameters showed significant differences suggesting sexual dimorphism. They serve as important anthropometric, clinical, and radiographic tools useful in the identification of deceased individuals as a part of forensic medicine and odontology.
{"title":"Morphometric analysis of palatal vault for sex determination in Central Indian population","authors":"Saurabh Sharma, Paran Joshi, Raman Grover","doi":"10.4103/kleuhsj.kleuhsj_219_23","DOIUrl":"https://doi.org/10.4103/kleuhsj.kleuhsj_219_23","url":null,"abstract":"BACKGROUND: Palate has been a topic of interest regarding sex determination from human skeletal remains in physical anthropology. Palatal index (PI) is an important parameter for the sex determination of deceased individuals with unknown identity. AIM: The study aimed to determine and compare PI, clinically and radiographically, and evaluate its role in sexual dimorphism in the Central Indian population. MATERIALS AND METHODS: This study was conducted on 392 participants, in the department of anatomy and dentistry of a premium medical college in India. Maxillary casts were used for clinical measurement. Posteroanterior and lateral cephalogram (Ceph) were used for the radiographic method. Palatal length (PL) and palatal breadth (PB) were measured. PI was calculated as PB/PL × 100. Data were analyzed using unpaired Student's t-test. RESULTS: Participants belonged to the age group of 41–50 years (31.63%), 51–60 years (27.04%), and 18–30 years (18.87%). Clinical and radiographic PB was found to be higher in males (37.94 ± 1.28 mm, 38.87 ± 3.11 mm) than females (35.44 ± 1.18 mm, 36.62 ± 2.75 mm). PL demonstrated almost similar clinical values in males (45.25 ± 1.65 mm) and females (45.21 ± 1.51 mm) with no statistical significance. Radiographic PL was significantly higher in males (48.28 ± 1.60 mm) than females (46.41 ± 1.69 mm). Males demonstrated higher PI, clinically and radiographically (83.84 ± 3.82 mm, 80.51 ± 5.32 mm), than females (78.38 ± 4.19 mm, 78.91 ± 5.06 mm). CONCLUSION: Palatal parameters showed significant differences suggesting sexual dimorphism. They serve as important anthropometric, clinical, and radiographic tools useful in the identification of deceased individuals as a part of forensic medicine and odontology.","PeriodicalId":13457,"journal":{"name":"Indian Journal of Health Sciences and Biomedical Research (KLEU)","volume":"122 1","pages":"403 - 407"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Foreign body aspiration (FBA) is one of the common causes of significant morbidity and mortality in a toddler child. Airway foreign bodies might be presented as a spectrum, ranging from the acute onset of choking, cyanosis, and respiratory distress to delayed onset of mild respiratory distress, wheezing, persistent cough, and fever. Here, we report a case of peanut aspiration in a toddler child, who was initially being treated as acute bronchial asthma, and the diagnosis was subsequently confirmed on computed tomography (CT) chest as a case of tracheal FBA. A foreign body was successfully retrieved by rigid bronchoscopy under general anesthesia and was a peanut by morphology. The possibility of FBA should be considered in any toddler child, who presents for the first time with acute bronchial asthma-like symptoms; wheezing, coughing, or respiratory distress. In a resource-limited setting, low-dose CT chest can be an early noninvasive diagnostic tool to detect all airway foreign bodies.
{"title":"Tracheal foreign body misdiagnosed as acute bronchial asthma in a toddler child","authors":"Bablu Gaur, Naadia Nazim, Sumanyu Ahuja, Anahita Fatma","doi":"10.4103/kleuhsj.kleuhsj_218_23","DOIUrl":"https://doi.org/10.4103/kleuhsj.kleuhsj_218_23","url":null,"abstract":"Foreign body aspiration (FBA) is one of the common causes of significant morbidity and mortality in a toddler child. Airway foreign bodies might be presented as a spectrum, ranging from the acute onset of choking, cyanosis, and respiratory distress to delayed onset of mild respiratory distress, wheezing, persistent cough, and fever. Here, we report a case of peanut aspiration in a toddler child, who was initially being treated as acute bronchial asthma, and the diagnosis was subsequently confirmed on computed tomography (CT) chest as a case of tracheal FBA. A foreign body was successfully retrieved by rigid bronchoscopy under general anesthesia and was a peanut by morphology. The possibility of FBA should be considered in any toddler child, who presents for the first time with acute bronchial asthma-like symptoms; wheezing, coughing, or respiratory distress. In a resource-limited setting, low-dose CT chest can be an early noninvasive diagnostic tool to detect all airway foreign bodies.","PeriodicalId":13457,"journal":{"name":"Indian Journal of Health Sciences and Biomedical Research (KLEU)","volume":"128 1","pages":"418 - 420"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.4103/kleuhsj.kleuhsj_582_22
Manoj Yadav, Poorvi Mathur, A. Singhai, Suresh Babu, Bhupendra Singh, Apul Goel, Ravi Lohani
INTRODUCTION: Cluster of differentiation 44 (CD44), a transmembrane glycoprotein and Matrix metalloproteinase 2 (MMP2), a gelatinase enzyme have been implicated in several malignancies for their role in prognostication and diagnosis. We, therefore, made an effort to use these markers in urothelial malignancies and discuss their importance along with review of the literature. METHODS: A prospective study conducted for 1 year using light microscopy and immunohistochemistry for CD44 and MMP2. RESULTS: CD44 showed concordance with low-grade tumors while MMP 2 was found to show positivity in high-grade tumors. Score 3 in CD44 expression was seen exclusively (100%) in low-grade tumors while similar score of MMP2 expression was seen in 90.9% of high-grade tumors. CONCLUSION: CD44 and MMP2 expression can, therefore, serve as an important tool to predict the clinical behavior and prognosis in patients of urothelial carcinoma of the bladder. The management and survival rate varies according to grade; hence, these markers can be used for prognostication of disease.
{"title":"Cluster of differentiation 44 and matrix metalloproteinase 2 markers: A prospective study and insight to their role in bladder cancer","authors":"Manoj Yadav, Poorvi Mathur, A. Singhai, Suresh Babu, Bhupendra Singh, Apul Goel, Ravi Lohani","doi":"10.4103/kleuhsj.kleuhsj_582_22","DOIUrl":"https://doi.org/10.4103/kleuhsj.kleuhsj_582_22","url":null,"abstract":"INTRODUCTION: Cluster of differentiation 44 (CD44), a transmembrane glycoprotein and Matrix metalloproteinase 2 (MMP2), a gelatinase enzyme have been implicated in several malignancies for their role in prognostication and diagnosis. We, therefore, made an effort to use these markers in urothelial malignancies and discuss their importance along with review of the literature. METHODS: A prospective study conducted for 1 year using light microscopy and immunohistochemistry for CD44 and MMP2. RESULTS: CD44 showed concordance with low-grade tumors while MMP 2 was found to show positivity in high-grade tumors. Score 3 in CD44 expression was seen exclusively (100%) in low-grade tumors while similar score of MMP2 expression was seen in 90.9% of high-grade tumors. CONCLUSION: CD44 and MMP2 expression can, therefore, serve as an important tool to predict the clinical behavior and prognosis in patients of urothelial carcinoma of the bladder. The management and survival rate varies according to grade; hence, these markers can be used for prognostication of disease.","PeriodicalId":13457,"journal":{"name":"Indian Journal of Health Sciences and Biomedical Research (KLEU)","volume":"23 1","pages":"361 - 365"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.4103/kleuhsj.kleuhsj_149_23
Harish Gupta
{"title":"Reading journals on phone","authors":"Harish Gupta","doi":"10.4103/kleuhsj.kleuhsj_149_23","DOIUrl":"https://doi.org/10.4103/kleuhsj.kleuhsj_149_23","url":null,"abstract":"","PeriodicalId":13457,"journal":{"name":"Indian Journal of Health Sciences and Biomedical Research (KLEU)","volume":"52 1","pages":"439 - 440"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139344346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.4103/kleuhsj.kleuhsj_240_23
S. Sahoo
{"title":"Celebrating World Hearing Day","authors":"S. Sahoo","doi":"10.4103/kleuhsj.kleuhsj_240_23","DOIUrl":"https://doi.org/10.4103/kleuhsj.kleuhsj_240_23","url":null,"abstract":"","PeriodicalId":13457,"journal":{"name":"Indian Journal of Health Sciences and Biomedical Research (KLEU)","volume":"6 1","pages":"333 - 335"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139345077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.4103/kleuhsj.kleuhsj_333_23
Vijaylaxmi Shettar, S. Baliga, Sanjay Rao, Prashasti Sharma, Kritika Pandey
Multiple facial bone fractures usually are consequential to severe injuries secondary to motor vehicle calamities. These complex and panfacial fractures are usually associated with multiple systemic injuries that mandate a multidisciplinary approach to their management. It involves rebuilding the facial architecture and restoring the facial buttresses to reinstate the cosmetics and function. The complex nature of treatment makes them challenging for the surgeon and thus requires an organized approach for efficient reduction. Various sequences such as bottom–up, top-to-bottom, and occlusion first have been commonly used. This case series presents two cases of complex facial fractures and two cases of panfacial fractures. In these cases, occlusion was first achieved by maxillomandibular fixation. The mandible was first reduced and fixed, followed by the maxilla.
{"title":"Management of panfacial and complex facial fractures: A Belgaum perspective – Case series","authors":"Vijaylaxmi Shettar, S. Baliga, Sanjay Rao, Prashasti Sharma, Kritika Pandey","doi":"10.4103/kleuhsj.kleuhsj_333_23","DOIUrl":"https://doi.org/10.4103/kleuhsj.kleuhsj_333_23","url":null,"abstract":"Multiple facial bone fractures usually are consequential to severe injuries secondary to motor vehicle calamities. These complex and panfacial fractures are usually associated with multiple systemic injuries that mandate a multidisciplinary approach to their management. It involves rebuilding the facial architecture and restoring the facial buttresses to reinstate the cosmetics and function. The complex nature of treatment makes them challenging for the surgeon and thus requires an organized approach for efficient reduction. Various sequences such as bottom–up, top-to-bottom, and occlusion first have been commonly used. This case series presents two cases of complex facial fractures and two cases of panfacial fractures. In these cases, occlusion was first achieved by maxillomandibular fixation. The mandible was first reduced and fixed, followed by the maxilla.","PeriodicalId":13457,"journal":{"name":"Indian Journal of Health Sciences and Biomedical Research (KLEU)","volume":"224 1","pages":"428 - 431"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.4103/kleuhsj.kleuhsj_170_23
Himanshi Vats, PAjay Kale
Primary hyperparathyroidism (PHPT) is usually seen in females above the age of 50 years, with a prevalence of 21/1000 whereas the incidence in patients aged 12–28 years is <5%. A solitary adenoma is responsible for 80% of cases of PHPT. PHPT is most commonly asymptomatic. The young age of the patient and her presentation with osteoporosis and bone fractures make this an extremely rare presentation of parathyroid adenoma (PTA). Here, we report a case of PTA in a young female presented with pathological fracture of tibia and humerus. The case was diagnosed as PTA based on clinical symptoms and investigations. Surgical intervention, i.e. parathyroidectomy was performed under GA.
{"title":"Rare case presentation of parathyroid adenoma in a young female presenting as pathological fracture of long bones: A case study","authors":"Himanshi Vats, PAjay Kale","doi":"10.4103/kleuhsj.kleuhsj_170_23","DOIUrl":"https://doi.org/10.4103/kleuhsj.kleuhsj_170_23","url":null,"abstract":"Primary hyperparathyroidism (PHPT) is usually seen in females above the age of 50 years, with a prevalence of 21/1000 whereas the incidence in patients aged 12–28 years is <5%. A solitary adenoma is responsible for 80% of cases of PHPT. PHPT is most commonly asymptomatic. The young age of the patient and her presentation with osteoporosis and bone fractures make this an extremely rare presentation of parathyroid adenoma (PTA). Here, we report a case of PTA in a young female presented with pathological fracture of tibia and humerus. The case was diagnosed as PTA based on clinical symptoms and investigations. Surgical intervention, i.e. parathyroidectomy was performed under GA.","PeriodicalId":13457,"journal":{"name":"Indian Journal of Health Sciences and Biomedical Research (KLEU)","volume":"57 1","pages":"424 - 427"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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