Pub Date : 2021-02-15DOI: 10.56042/ijcb.v60i2.35076
N. Desai, J. P. Harsorab, H. Mehtaa
An efficient synthetic strategy for the synthesis of 6-amino-1-(((2-chloroquinolin-3-yl)methylene)amino)-2-oxo-4-(aryl)-1,2-dihydropyridine-3,5-dicarbonitriles is well described in this paper. Structures of synthesized compounds have been identified by standard spectroscopic techniques like 1 H NMR, 13 C NMR, IR and mass spectroscopy. Results of the biological activity reveals that electron withdrawing groups and presence of –OH group on meta position play a significant role for the increment in the antibacterial and antifungal activities respectively of 3a-j . In the present study, it has been observed that compounds 3i and 3e are the most active antimicrobials.
{"title":"2-Pyridone quinoline hybrids as potent antibacterial and antifungal agents","authors":"N. Desai, J. P. Harsorab, H. Mehtaa","doi":"10.56042/ijcb.v60i2.35076","DOIUrl":"https://doi.org/10.56042/ijcb.v60i2.35076","url":null,"abstract":"An efficient synthetic strategy for the synthesis of 6-amino-1-(((2-chloroquinolin-3-yl)methylene)amino)-2-oxo-4-(aryl)-1,2-dihydropyridine-3,5-dicarbonitriles is well described in this paper. Structures of synthesized compounds have been identified by standard spectroscopic techniques like 1 H NMR, 13 C NMR, IR and mass spectroscopy. Results of the biological activity reveals that electron withdrawing groups and presence of –OH group on meta position play a significant role for the increment in the antibacterial and antifungal activities respectively of 3a-j . In the present study, it has been observed that compounds 3i and 3e are the most active antimicrobials.","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79067342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-15DOI: 10.56042/ijcb.v60i2.30557
{"title":"Computational calculations and molecular docking studies on 2-(2-ethylaminothiazol-5-oyl)benzothiazole","authors":"","doi":"10.56042/ijcb.v60i2.30557","DOIUrl":"https://doi.org/10.56042/ijcb.v60i2.30557","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90814466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-21DOI: 10.56042/ijcb.v59i05.45463
{"title":"Prediction of agonist, partial agonist and full antagonist of H. pylori TlpB utilizing molecular docking","authors":"","doi":"10.56042/ijcb.v59i05.45463","DOIUrl":"https://doi.org/10.56042/ijcb.v59i05.45463","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72451496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-21DOI: 10.56042/ijcb.v59i05.45479
Akeel Ahmada, Shailendra Tiwari
Potassium carbonate in poly (ethylene glycol-400) has been found to be a highly effective and efficient medium for the straight forward, convenient, one pot and green synthesis of ethyl 2-substituted phenyl-7-oxo-7 H -[1,3,4]- thiadiazolo [3,2-a]- pyrimidine-6-corboxylate and -6-corbonitrile through intramolecular cyclo-elimination of Michael adducts formed between the reaction of 2-amino-5 substituted thiadiazoles with diethyl-2- (ethoxymethylene) malonate and ethyl-2- cyano-3-ethoxyacrylate respectively. The structures of all the new compounds have been elucidated using IR, 1 H and 13 C NMR, mass spectral data and elemental analyses.
聚乙烯醇-400中的碳酸钾是一种高效、直接、方便、通过分子内环消除2-氨基-5取代噻二唑与二乙基-2-(乙氧基亚甲基)丙二酸二乙酯和乙基-2-氰基-3-乙氧基丙烯酸酯反应形成的Michael加合物，一锅绿色合成了2-取代苯基-7-氧基-7 H -[1,3,4]-噻二唑[3,2-a]-嘧啶-6-羧酸酯和-6-腈。所有新化合物的结构已通过IR、1h和13c NMR、质谱数据和元素分析进行了鉴定。
{"title":"A one pot, efficient and eco-friendly synthesis of 1,3,4-thiadiazolo[3,2-a] pyrimidine scaffold via Aza–Michael addition and intramolecular cyclo-elimination reactions in poly ethylene glycol (PEG)","authors":"Akeel Ahmada, Shailendra Tiwari","doi":"10.56042/ijcb.v59i05.45479","DOIUrl":"https://doi.org/10.56042/ijcb.v59i05.45479","url":null,"abstract":"Potassium carbonate in poly (ethylene glycol-400) has been found to be a highly effective and efficient medium for the straight forward, convenient, one pot and green synthesis of ethyl 2-substituted phenyl-7-oxo-7 H -[1,3,4]- thiadiazolo [3,2-a]- pyrimidine-6-corboxylate and -6-corbonitrile through intramolecular cyclo-elimination of Michael adducts formed between the reaction of 2-amino-5 substituted thiadiazoles with diethyl-2- (ethoxymethylene) malonate and ethyl-2- cyano-3-ethoxyacrylate respectively. The structures of all the new compounds have been elucidated using IR, 1 H and 13 C NMR, mass spectral data and elemental analyses.","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83550534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-21DOI: 10.56042/ijcb.v59i05.45469
{"title":"Synthesis, anti-tuberculosis and anti-bacterial activities of sulfonamide bearing 4-((2-(5-bromo-1H-pyrazolo[3,4-b]pyridin-1-yl)-2-oxoethyl)amino)-N-(various substitutions)benzenesulfonamide","authors":"","doi":"10.56042/ijcb.v59i05.45469","DOIUrl":"https://doi.org/10.56042/ijcb.v59i05.45469","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76412522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.56042/ijcb.v60i01.40509
{"title":"Free radical scavenging and α-glucosidase inhibitory activity of (E)-methyl/ethyl-3-(2-hydroxyphenyl)acrylates","authors":"","doi":"10.56042/ijcb.v60i01.40509","DOIUrl":"https://doi.org/10.56042/ijcb.v60i01.40509","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72517011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.56042/ijcb.v60i01.40586
D. Anusha, G. Praveena, A. Zehra, A. Tiwari, R. Prakasham, B. Raju
{"title":"A convenient synthesis and biological activities of N-(pyridin-3-ylmethylene) benzohydrazides by the condensation of nicotinaldehydes with benzohydrazides","authors":"D. Anusha, G. Praveena, A. Zehra, A. Tiwari, R. Prakasham, B. Raju","doi":"10.56042/ijcb.v60i01.40586","DOIUrl":"https://doi.org/10.56042/ijcb.v60i01.40586","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88307902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.56042/ijcb.v60i01.29388
Fatemeh Noori Sadeha, M. Lashkari, Nourallah Hazeria, Maryam Fatahpoura, Malek Taher Maghsoodloua, Mohammad Saeed Hadavic, Sahar Mahnaeic
As a segment of ongoing surveys and with the aim of expansion of environmentally benign processes, a series of biologically varied type of substituted 2-amino-3-cyano-4 H -pyrans and pyran-annulated Scaffolds have been synthesized by tandem Knoevenagel-cyclocondensation of aldehydes, malononitrile, and C-H-activated acidic compounds in aqueous ethanol in the presence of Ag/TiO 2 nano-thin films as an eco-friendly, recyclable, and, robust catalyst at 60°C. The salient features of this protocol are mild reaction conditions, producing target compounds in high yields, short reaction times, high atom economy, eco-friendly catalyst, easy isolation of products and no column chromatographic separation. Also, it is observed that the catalyst is highly stable during the reaction and several reuse times without observable loss in catalytic performance.
{"title":"Three-component coupling approach for the synthesis of 4H-pyrans and pyran-annulated heterocyclic scaffolds utilizing Ag/TiO2 nano-thin films as robust recoverable catalyst","authors":"Fatemeh Noori Sadeha, M. Lashkari, Nourallah Hazeria, Maryam Fatahpoura, Malek Taher Maghsoodloua, Mohammad Saeed Hadavic, Sahar Mahnaeic","doi":"10.56042/ijcb.v60i01.29388","DOIUrl":"https://doi.org/10.56042/ijcb.v60i01.29388","url":null,"abstract":"As a segment of ongoing surveys and with the aim of expansion of environmentally benign processes, a series of biologically varied type of substituted 2-amino-3-cyano-4 H -pyrans and pyran-annulated Scaffolds have been synthesized by tandem Knoevenagel-cyclocondensation of aldehydes, malononitrile, and C-H-activated acidic compounds in aqueous ethanol in the presence of Ag/TiO 2 nano-thin films as an eco-friendly, recyclable, and, robust catalyst at 60°C. The salient features of this protocol are mild reaction conditions, producing target compounds in high yields, short reaction times, high atom economy, eco-friendly catalyst, easy isolation of products and no column chromatographic separation. Also, it is observed that the catalyst is highly stable during the reaction and several reuse times without observable loss in catalytic performance.","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82319331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.56042/ijcb.v60i01.31340
{"title":"Exploration of anticancer potential of hydroxamate derivatives as selective HDAC8 inhibitors using integrated structure and ligand based molecular modeling approach","authors":"","doi":"10.56042/ijcb.v60i01.31340","DOIUrl":"https://doi.org/10.56042/ijcb.v60i01.31340","url":null,"abstract":"","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83554707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-20DOI: 10.56042/ijcb.v60i01.31988
R. Verma, Chitra Guptab, Ali Mohd Ganieb, S. Singha, P. K. Singhc
Benzimidazole is the heterocyclic compound formed by the fusion of benzene and imidazole ring. Benzimidazole analogs are of great significance because of their clinical application and biological activity. Benzimidazoles are considered as an optimistic class of bioactive heterocyclic compound that possesses a range of biological activities. We have synthesized five substituted Benzimidazole derivative using on both microwave irradiation and conventional heating method. The newly synthesized compounds are characterized by IR, NMR and Mass spectra analysis. In the present study, we have reported the synthesis, spectral studies and biological evaluation of some benzimidazole derivatives. Benzimidazole play important role in medical field with so many pharmacological activities such as antimicrobial, anti bacterial, etc. The potency of this clinically useful drug in treatment in microbial action and other activities has encouraged the development of some more potent and significant compounds.
{"title":"Synthesis, characterization and potent antimicrobial and antifungal activity of 2-substituted benzimidazole derivatives","authors":"R. Verma, Chitra Guptab, Ali Mohd Ganieb, S. Singha, P. K. Singhc","doi":"10.56042/ijcb.v60i01.31988","DOIUrl":"https://doi.org/10.56042/ijcb.v60i01.31988","url":null,"abstract":"Benzimidazole is the heterocyclic compound formed by the fusion of benzene and imidazole ring. Benzimidazole analogs are of great significance because of their clinical application and biological activity. Benzimidazoles are considered as an optimistic class of bioactive heterocyclic compound that possesses a range of biological activities. We have synthesized five substituted Benzimidazole derivative using on both microwave irradiation and conventional heating method. The newly synthesized compounds are characterized by IR, NMR and Mass spectra analysis. In the present study, we have reported the synthesis, spectral studies and biological evaluation of some benzimidazole derivatives. Benzimidazole play important role in medical field with so many pharmacological activities such as antimicrobial, anti bacterial, etc. The potency of this clinically useful drug in treatment in microbial action and other activities has encouraged the development of some more potent and significant compounds.","PeriodicalId":13458,"journal":{"name":"Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87357294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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