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The Relationship of Immune Markers with Severity and Heritability of Depressive Disorder: A Cross-Sectional Hospital-Based Study from North India 免疫标志物与抑郁症严重程度和遗传性的关系:一项基于北印度医院的横断面研究
IF 2.8 Q3 PSYCHIATRY Pub Date : 2024-09-01 DOI: 10.1177/02537176241275537
Anshu Prasad, Priyaranjan Avinash, Robin Victor, Kiran Bhat
Background:Inflammatory response plays a pivotal role in the pathophysiology of depression. With this background, we planned this study to see if immune markers, interleukin 6 (IL-6), and erythrocyte sedimentation rate (ESR) are raised in subjects with major depressive disorder (MDD) and compare its level with healthy controls and first-degree relatives of subjects. We also explored if variation in the level of these markers was related to the severity of depression.Methods:This comparative observational study included 120 subjects, who were divided into three groups of 40 individuals each. Group 1 was the MDD group, group 2 was the healthy first-degree relative group, and group 3 was the healthy control group. All the subjects were then made to undergo estimation of IL-6 (pg/mL) and ESR (mm/h) from our hospital biochemistry lab. The patients in group 1 were additionally screened for the severity of depression.Results:The mean IL-6 and ESR measure within the MDD group was 9.20 ± 13.40 (pg/mL) and 5.90 ± 5.35 (mm/h), respectively. We found that the mean and median values of both IL-6 and ESR were highest in the MDD group as compared to other groups, which were statistically significant ( p <0.05). A pairwise comparison found no significant difference in the IL-6 and ESR scores among the healthy controls and healthy first-degree relatives. The mean of IL-6 was highest in individuals with moderate severity of depression, while the mean of ESR was highest in individuals with severe depression.Conclusion:The immune markers, IL-6 and ESR, were significantly raised in the MDD group; however, the levels did not correlate significantly with the differential severity of the depressive disorder as per Hamilton depression rating scale (HAM-D) scores.
背景:炎症反应在抑郁症的病理生理学中起着关键作用。在此背景下,我们计划开展这项研究,以了解重度抑郁症(MDD)患者的免疫标志物、白细胞介素6(IL-6)和红细胞沉降率(ESR)是否升高,并将其水平与健康对照组和患者的一级亲属进行比较。我们还探讨了这些指标水平的变化是否与抑郁症的严重程度有关。第一组为多发性抑郁症组,第二组为一级亲属健康组,第三组为健康对照组。然后,所有受试者都接受了本院生化实验室的 IL-6(pg/mL)和血沉(mm/h)测定。结果:MDD 组的 IL-6 和 ESR 平均值分别为 9.20 ± 13.40(pg/mL)和 5.90 ± 5.35(mm/h)。我们发现,与其他组相比,MDD 组的 IL-6 和 ESR 的平均值和中位值最高,这在统计学上有显著意义(p <0.05)。配对比较发现,健康对照组和健康一级亲属的 IL-6 和 ESR 评分无明显差异。IL-6的平均值在中度抑郁症患者中最高,而ESR的平均值在重度抑郁症患者中最高。
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引用次数: 0
Treatment Needs of Patients With Severe Alcohol Use Disorders 严重酒精使用障碍患者的治疗需求
IF 2.8 Q3 PSYCHIATRY Pub Date : 2024-08-28 DOI: 10.1177/02537176241276151
Venkata Lakshmi Narasimha, Arvind BA, Ramana Tadepalli, Arun Kandasamy, Pratima Murthy
Background:People with alcohol use disorders (AUDs) have varied needs while they seek treatment. Understanding and focusing on the needs will improve treatment outcomes. The objective of the study is to qualitatively assess the treatment-related needs of patients with AUDs admitted to a tertiary care treatment center.Methods:A semi-structured questionnaire with anchor questions was developed based on a literature review and key informant interviews. All the interviews were audio recorded, transcribed, and color-coded manually. Two reviewers reviewed the codes. Themes and subthemes were generated using thematic inductive analysis.Results:Among 15 patients interviewed, all the patients had severe AUD (100%), were married (100%), were primarily males (86.6%), and more than half below the poverty line (53.4%), with a mean age of 41.1 years (SD = 9.5). Four major themes of treatment needs were identified: (a) individual, (b) family-related, (c) hospital-related, and (d) community-related. Among individual needs-medication-related, psychological, and occupational were prominent. Addressing family conflict and supporting the family are the significant subthemes for family-related needs. The behavior of the treating team, environmental needs, and diverse services were significant hospital-related needs. Awareness, accessibility, availability, and affordability of treatment services were the major community-related needs.Conclusion:The study highlights diverse needs extending from individual to community among people with AUDs. A holistic treatment model to address these needs will improve the quality of care and treatment outcomes.
背景:酒精使用障碍(AUD)患者在寻求治疗时有不同的需求。了解并关注这些需求将有助于提高治疗效果。本研究旨在定性评估一家三级护理治疗中心收治的酒精使用障碍患者的治疗相关需求。方法:根据文献综述和关键信息提供者访谈,编制了一份半结构化问卷,其中包含锚定问题。所有访谈均进行了录音、转录和人工彩色编码。两名审查员对编码进行了审查。结果:在接受访谈的 15 名患者中,所有患者均患有严重的 AUD(100%),已婚(100%),主要为男性(86.6%),一半以上处于贫困线以下(53.4%),平均年龄为 41.1 岁(SD = 9.5)。确定了治疗需求的四大主题:(a) 个人需求,(b) 与家庭有关的需求,(c) 与医院有关的需求,以及 (d) 与社区有关的需求。在个人需求中,与用药相关的需求、心理需求和职业需求最为突出。解决家庭冲突和支持家庭是与家庭相关需求的重要次主题。治疗团队的行为、环境需求和多样化服务是与医院相关的重要需求。结论:本研究强调了从个人到社区的不同需求。针对这些需求的整体治疗模式将提高护理质量和治疗效果。
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引用次数: 0
A Local Vernacular Variant of the Foreign Accent Syndrome Associated with Wernicke’s Aphasia Masquerading as Dissociative Neurological Symptom Disorder: A Case Report 外来语口音综合征的本地方言变体,伴有韦尼克失语症,伪装成分离性神经症状障碍:病例报告
IF 2.8 Q3 PSYCHIATRY Pub Date : 2024-08-28 DOI: 10.1177/02537176241262868
Anirudh Bakam, Sai Krishna Tikka, Abhishek J. Arora, Vishakha Jain, B. C. Malathesh, Sai Spoorthy Mamidipalli, Tekupalli Sushank Tej
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引用次数: 0
Comments on “Stress, Anxiety, and Depression Before and Twelve Months After Bariatric Surgery: Repeated Cross-sectional Study” 关于 "减肥手术前后十二个月的压力、焦虑和抑郁:重复横断面研究"
IF 2.8 Q3 PSYCHIATRY Pub Date : 2024-08-26 DOI: 10.1177/02537176241268993
Aditya Somani, Bheemsain Tekkalaki, Mirza Jahanzeb Beg, Gurvinder Pal Singh, Yugesh Rai, Vasudeo Paralikar, Amal Jolly, Chittaranjan Andrade
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引用次数: 0
Reply to the Comments on “Stress, Anxiety, and Depression Before and 12 Months After Bariatric Surgery: Repeated Cross-Sectional Study” 回复关于 "减肥手术前后 12 个月的压力、焦虑和抑郁:重复横断面研究"
IF 2.8 Q3 PSYCHIATRY Pub Date : 2024-08-26 DOI: 10.1177/02537176241268994
Amani Safwat ElBarazi
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引用次数: 0
The Outcome Evaluation and Impact of Tele-mentoring Prison Medical Officers in Primary Care Psychiatry: A Model from Bihar, India 对监狱医务人员进行初级精神病学远程辅导的成果评估和影响:印度比哈尔邦的模式
IF 2.8 Q3 PSYCHIATRY Pub Date : 2024-08-19 DOI: 10.1177/02537176241263294
Naveen C. Kumar, B. Sai Chaitanya Reddy, P. Laxmi Nirisha, Shivanee Kumari, Sivakami Sundari Subramaniyan, Narayana Manjunatha, Suresh Bada Math
Introduction:As compared to the general population, prison inmates have a high prevalence of mental illness and substance use disorders. The authors designed and implemented a digitally driven, one-year primary care psychiatry program for medical officers in prison and correctional settings to address this need in Bihar, India.Aim:The study aimed to assess the outcome of training given to prison medical officers deputed by the Government of Bihar.Materials and Method:Five medical officers completed training out of the seven deputed. The training contained brief onsite (three-day) training in “Clinical Schedules for Primary Care Psychiatry” and three online (one-year) modules containing tele-psychiatric on-consultation training (tele-OCT), virtual classroom (VCR) sessions, and a public health module. We measured the outcome using translational quotient (TQ) and primary care psychiatry quotient (PCPQ), which were carried out 6 and 12 months after the onset of training.Results:The TQ scores in the first and second tele-OCT evaluations were 64% and 75.2% at 6 and 12 months of the course, suggesting adequate skill retention. Out of 33,565 consultations over 12 months, medical officers identified 2,947 psychiatric disorders requiring treatment, resulting in a PCPQ of 8.7%.Conclusion:Over a year, the training demonstrated efficacy in acquiring primary care psychiatry skills, and these competencies were applied in providing care for those with psychiatric disorders.
导言:与普通人群相比,监狱囚犯的精神疾病和药物使用障碍发病率较高。作者针对印度比哈尔邦的这一需求,为监狱和惩教机构的医务人员设计并实施了一项为期一年的数字化初级精神病学培训项目。研究旨在评估比哈尔邦政府为监狱医务人员提供的培训成果。培训内容包括为期三天的 "初级精神病学临床表 "简短现场培训,以及三个在线模块(为期一年),包括远程精神科会诊培训(tele-OCT)、虚拟课堂(VCR)和公共卫生模块。我们使用翻译商数(TQ)和初级保健精神病学商数(PCPQ)对培训结果进行了测评,测评在培训开始后 6 个月和 12 个月进行。结果:在课程结束后 6 个月和 12 个月,第一次和第二次远程 OCT 评估的 TQ 分数分别为 64% 和 75.2%,表明技能保留充分。在 12 个月的 33,565 次问诊中,医务人员发现了 2,947 例需要治疗的精神疾病,PCPQ 为 8.7%。结论:在一年的培训中,医务人员掌握了初级精神科护理技能,并将这些能力应用于为精神疾病患者提供护理。
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引用次数: 0
Immune Checkpoint Inhibitors and Their Impact on Thoughts, Feelings, and Behavior: Cognitive and Psychiatric Manifestations of Immune Checkpoint Therapy 免疫检查点抑制剂及其对思想、情感和行为的影响:免疫检查点疗法的认知和精神表现
IF 2.8 Q3 PSYCHIATRY Pub Date : 2024-08-19 DOI: 10.1177/02537176241263308
Jai Ahuja, Kushagra Varma
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引用次数: 0
Online Mental Health Peer-support Forums for Youth: An Exploratory Study on Stakeholder Perspectives 青少年在线心理健康同伴互助论坛:利益相关者观点的探索性研究
IF 2.8 Q3 PSYCHIATRY Pub Date : 2024-08-18 DOI: 10.1177/02537176241265558
Meghna Achar, Seema Mehrotra
Background:Youth in India carry a large proportion of the global burden of mental health disorders and subclinical distress. They prefer to seek mental health support from informal sources. One such source—online mental health peer-support forums (OMHPSFs)—is under-researched. This study aims to explore the perspectives of youth and mental health professionals and counselors (MHP&Cs) in terms of the scope and utility of and inclination to use OMHPSFs for maintaining youth mental well-being.Methods:An exploratory, cross-sectional, mixed-methods study was conducted. A total of 141 Indian nationals aged 18–29 years were enrolled using convenience sampling and administered a survey. In the qualitative phase, six youth and seven MHP&Cs were interviewed.Results:Ninety (63.8%) and 106 (75.2%) participants indicated a high inclination to use OMHPSFs to seek and provide support, respectively. More than three-quarters of the surveyed youth stated that OMHPSFs should be a space for emotional and informational support to deal with life challenges. A total of 127 (90.1%) participants reported that OMHPSFs would be useful to find out how others their age deal with similar life challenges. A thematic analysis of interviews revealed that anonymity, accessibility, appeal, and ease of use enhance youth inclination toward OMHPSFs. The role of MHP&Cs in training, supervision, and moderation and strategies to popularize OMHPSFs were outlined and recommended.Conclusion:Sampled youth showed a high inclination to use OMHPSFs to seek and provide mental health support to their peers. Stakeholders consider OMHPSFs as relevant in scope and utility to alleviate mental health concerns among Indian youth.
背景:在全球精神疾病和亚临床痛苦的负担中,印度青年占了很大一部分。他们更愿意从非正式渠道寻求心理健康支持。对其中一个渠道--在线心理健康同伴支持论坛(OMHPSFs)--的研究不足。本研究旨在探讨青少年和心理健康专业人员及辅导员(MHP&Cs)对在线心理健康同伴支持论坛(OMHPSFs)在维护青少年心理健康方面的范围、效用和使用倾向的看法。研究采用便利抽样法,共招募了 141 名 18-29 岁的印度国民,并对他们进行了问卷调查。结果显示:分别有 90 名(63.8%)和 106 名(75.2%)参与者表示非常倾向于使用 OMHPSFs 寻求支持和提供支持。超过四分之三的受访青少年表示,OMHPSF 应该是一个提供情感和信息支持的空间,以应对生活中的挑战。共有 127 名参与者(90.1%)表示,OMHPSF 对于了解同龄人如何应对类似的生活挑战非常有用。对访谈进行的主题分析表明,匿名性、可及性、吸引力和易用性增强了青少年对 OMHPSF 的倾向性。结论:被抽样调查的青少年非常倾向于使用 OMHPSFs 来寻求心理健康支持并为同伴提供心理健康支持。利益相关者认为,OMHPSF 在范围和效用上都与缓解印度青少年的心理健康问题相关。
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引用次数: 0
Development and Validation of a Culturally Adapted, Event-related Potential Paradigm for Assessing Alcohol Cue Reactivity and Error Processing in Alcohol Dependence 开发并验证一种适应不同文化的事件相关电位范式,用于评估酒精依赖症患者的酒精线索反应性和错误处理能力
IF 2.8 Q3 PSYCHIATRY Pub Date : 2024-08-18 DOI: 10.1177/02537176241266879
Anupa Arunkumar Shenoy, Samir Kumar Praharaj, Shweta Rai, Kirtana R. Nayak, Arun Sasidharan, Hari Prakash Palaniswamy, Chinmay Ajit Suryavanshi, Sumit Sharma, Umesh Shreekantiah, Vrinda Marigowda
Background:Research on event-related potentials (ERP) in addiction highlights the importance of cognitive ERP markers, such as P300 and error-related negativity (ERN), in distinguishing between alcohol-dependent patients and healthy controls. We aimed to develop and validate ERP paradigms utilizing culturally validated stimuli to evoke P300 and ERN for the Indian population.Methods:In a cross-sectional study, 16 alcohol-dependent patients and age-matched healthy controls were recruited. For P300, we designed a visual oddball (Go/No-Go) task using culturally appropriate alcohol and non-alcohol-related images. To study ERN, we used the Assessing Neurocognition via Gamified Experimental Logic (ANGEL) task, developed in India, integrating its “game” levels to capture error monitoring with fewer trials. A 32-channel EEG-ERP system was used for data acquisition.Results:Participants showed high engagement in the visual Go/No-Go task, with 94.4% accuracy. The P300 difference wave showed significantly higher amplitudes ( p = .01, Cohen’s d = 0.97) and latencies ( p < .001, Cohen’s d = 1.62) in patients compared to controls at the Pz electrode. No significant group differences were found in accuracy or reaction times for frequent and rare stimuli. In the ANGEL task, patients had a significantly lower ERN difference wave amplitude at the Pz electrode than controls ( p < .001, Cohen’s d = 1.47), with no latency differences. Task accuracy was lower, and reaction time was longer in patients.Conclusions:The visual Go/No-Go task and the ANGEL task are promising tools for understanding the neurocognitive mechanisms underlying alcohol dependence in the Indian context.
背景:对成瘾事件相关电位(ERP)的研究强调了认知ERP标记(如P300和错误相关负性(ERN))在区分酒精依赖症患者和健康对照组方面的重要性。方法:在一项横断面研究中,我们招募了 16 名酒精依赖症患者和年龄匹配的健康对照者。为了研究 P300,我们设计了一个视觉怪球(Go/No-Go)任务,使用文化上适当的酒精和非酒精相关图像。为了研究 ERN,我们使用了印度开发的 "通过游戏化实验逻辑评估神经认知"(ANGEL)任务,该任务整合了 "游戏 "水平,以较少的试验次数捕捉错误监测。结果:参与者在视觉 "去/不去 "任务中表现出很高的参与度,准确率达到 94.4%。与对照组相比,患者在 Pz 电极处的 P300 差异波的振幅(p = .01,Cohen's d = 0.97)和潜伏期(p < .001,Cohen's d = 1.62)明显更高。在频繁刺激和罕见刺激的准确性或反应时间方面,没有发现明显的组间差异。在 ANGEL 任务中,患者在 Pz 电极的 ERN 差搏波幅明显低于对照组(p < .001,Cohen's d = 1.47),且无潜伏期差异。结论:视觉 Go/No-Go 任务和 ANGEL 任务是了解印度酒精依赖症神经认知机制的有效工具。
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引用次数: 0
Suicide and Socio-demography: An Ecological Study from India 自杀与社会人口:印度生态研究
IF 2.8 Q3 PSYCHIATRY Pub Date : 2024-08-14 DOI: 10.1177/02537176241262696
Sujita Kumar Kar, Chandrima Naskar, Marthoenis Marthoenis, Shivank Tomer, Vikas Menon, S. M. Yasir Arafat
Background:Recent studies are coming out assessing the relationship between suicide rates and various ecological variables. However, information on the association between suicide rate and ecological variables in India has been limited. We aimed to measure the association of suicide rate with religion, literacy, gross domestic product, human development index, life expectancy, fertility, urbanization, and unemployment in India.Methods:We extracted 36 states or union territories of India and their suicide rate, the proportion of Hindu and Muslim populations, literacy rate, per capita gross domestic product (GDP), Human Development Index (HDI), life expectancy, fertility rate, urbanization, and unemployment rate. We assessed the association with rate and other ecological variables mentioned.Results:Suicide rates were positively correlated with the percentage of Hindu population in the state (rs = 0.38, p = .022), literacy rate (rs = 0.368, p = .027), and GDP (rs = 0.61, p = .001), whereas they were negatively correlated with fertility (rs = –0.442, p = .039) and unemployment rate (rs = –0.4, p = .015). We did not find any significant association between suicide rate and Muslim populations, HDI, life expectancy, and urbanization.Conclusion:This study’s findings identified several associations between ecological variables and suicide rates. However, based on the nature of the analysis, a cautious interpretation and further investigations are warranted.
背景:最近有研究对自杀率与各种生态变量之间的关系进行了评估。然而,有关印度自杀率与生态变量之间关系的信息却很有限。我们的目的是测量印度自杀率与宗教、识字率、国内生产总值、人类发展指数、预期寿命、生育率、城市化和失业率之间的关系。方法:我们提取了印度 36 个邦或中央直辖区的数据,以及它们的自杀率、印度教和穆斯林人口比例、识字率、人均国内生产总值(GDP)、人类发展指数(HDI)、预期寿命、生育率、城市化和失业率。我们评估了自杀率与其他生态变量之间的关联。结果:自杀率与该邦印度教人口比例(rs = 0.38,p = .022)、识字率(rs = 0.368,p = .027)和国内生产总值(rs = 0.61,p = .001)呈正相关,而与生育率(rs = -0.442,p = .039)和失业率(rs = -0.4,p = .015)呈负相关。我们没有发现自杀率与穆斯林人口、人类发展指数、预期寿命和城市化之间有任何明显的关联。然而,基于分析的性质,我们有必要对其进行谨慎的解释和进一步的调查。
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引用次数: 0
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Indian Journal of Psychological Medicine
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