Z. Khan, Jibin Mathai, Mudkappa Keshannavar, M. Shalavadi
Background: HIV/AIDS is reduced from a formerly lethal disease to a manageable chronic condition post advent of ART, the art era has promised new life standards and improving QOL of PLHIV, anyhow there are issues regarding adherence patterns where both patterns of adherence come with certain complications. Objectives: To retrospectively analyze for ADRs that are due to Antiretrovirals. To study the most prevalent reasons behind admission to hospital in PLHIV. To study mean age and inter-age prevalence of OIs and Drug-induced manifestations in PLHIV. To provide a database aiding in framing policies for the betterment of PLHIV. To synthesize results that can improve the QOL of PLHIV. Materials and Methods: We searched for all case files from 2018 to 2020 to screen for reasons why PLHIVs were admitted to a tertiary care teaching hospital and then looked into Google Scholar, Pubmed, etc. with keywords such as HIV, PLHIV, Complications of HAART, and many such to study the underlying reasons for the outcome seeking intervention. We also analyzed prescription patterns in the meanwhile to arrive at conclusions about various complications and modalities of treatment for the same. Results and Conclusion: Anemia is seen to be very prevalent amongst PLHIV accounting for about 54% of the population, Hepatotoxicity, Lipodystrophy, and an array of metabolic disorders can be linked to Drugs, and outcomes which were rare and difficult to manage were usually due to the nonadherent pattern. Although new incidences of Cranial lesions are being reported research in this direction is quasistatic post 90’s. The most common drugs that cause ADRs belong to the class of NNRTIs followed by protease inhibitors. Although new novel drugs are available, their prescription is almost not seen. And more awareness is needed in this regard.
{"title":"A Retrospective Case Series Study on Drug Adherence Patterns and Associated Complications in PLHIV on HAART in a Tertiary Care Teaching Hospital","authors":"Z. Khan, Jibin Mathai, Mudkappa Keshannavar, M. Shalavadi","doi":"10.5530/ijopp.15.4.53","DOIUrl":"https://doi.org/10.5530/ijopp.15.4.53","url":null,"abstract":"Background: HIV/AIDS is reduced from a formerly lethal disease to a manageable chronic condition post advent of ART, the art era has promised new life standards and improving QOL of PLHIV, anyhow there are issues regarding adherence patterns where both patterns of adherence come with certain complications. Objectives: To retrospectively analyze for ADRs that are due to Antiretrovirals. To study the most prevalent reasons behind admission to hospital in PLHIV. To study mean age and inter-age prevalence of OIs and Drug-induced manifestations in PLHIV. To provide a database aiding in framing policies for the betterment of PLHIV. To synthesize results that can improve the QOL of PLHIV. Materials and Methods: We searched for all case files from 2018 to 2020 to screen for reasons why PLHIVs were admitted to a tertiary care teaching hospital and then looked into Google Scholar, Pubmed, etc. with keywords such as HIV, PLHIV, Complications of HAART, and many such to study the underlying reasons for the outcome seeking intervention. We also analyzed prescription patterns in the meanwhile to arrive at conclusions about various complications and modalities of treatment for the same. Results and Conclusion: Anemia is seen to be very prevalent amongst PLHIV accounting for about 54% of the population, Hepatotoxicity, Lipodystrophy, and an array of metabolic disorders can be linked to Drugs, and outcomes which were rare and difficult to manage were usually due to the nonadherent pattern. Although new incidences of Cranial lesions are being reported research in this direction is quasistatic post 90’s. The most common drugs that cause ADRs belong to the class of NNRTIs followed by protease inhibitors. Although new novel drugs are available, their prescription is almost not seen. And more awareness is needed in this regard.","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"130 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77929530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
When we hear the terms "PCOD" and "PCOS," the first thing we probably think of is "irregular periods," isn't it? Regarding these diseases, there is still a lot of ignorance. The two abbreviations are frequently used interchangeably, despite the fact that they refer to two quite different conditions, and there is a lot of misinformation and myths surrounding these surprisingly common health problems.
{"title":"PCOD and PCOS: Are they same or Different???","authors":"B. V. Rao","doi":"10.5530/ijopp.15.4.46","DOIUrl":"https://doi.org/10.5530/ijopp.15.4.46","url":null,"abstract":"When we hear the terms \"PCOD\" and \"PCOS,\" the first thing we probably think of is \"irregular periods,\" isn't it? Regarding these diseases, there is still a lot of ignorance. The two abbreviations are frequently used interchangeably, despite the fact that they refer to two quite different conditions, and there is a lot of misinformation and myths surrounding these surprisingly common health problems.","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78703262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
(RPRF) Rapidly progressive renal failure is categorized by a rapid loss of kidney functions over days to weeks. Acute kidney injury is a sudden episode of kidney failure or kidney damage that happens within a few hours to days. Non-Steroidal Anti-Inflammatory Drugs and/or acetaminophen are commonly used in mild to moderate pain management. NSAID and/or acetaminophen have been reported to cause reversible acute renal failure. A 68-year-old male patient brought with the chief complaints on admission of vomiting, breathlessness since 4 days, pain in the abdomen since 5 days, burning sensation in chest, burning micturition, haematuria since 2 weeks. He was a known case of wind-swept deformity and receiving combination of Tablet Diclofenac sodium 50 mg/Acetaminophen 500 mg once a day in the past 8 years for knee pain. He was diagnosed with Rapidly Progressive Renal Failure-Acute Kidney Injury, Contrast induced Nephropathy, Bladder Outlet Obstruction. The laboratory investigations show abnormality in the serum creatinine, blood urea, haematological parameters indicate normocytic normochromic anaemia with neutrophilic leucocytosis. In the assessment of this case it was found that Diclofenac/Acetaminophen has induced Rapidly Progressive Renal Failure. After withdrawal of Diclofenac/Acetaminophen all the values returned within the normal range and his oedema was also subsiding, showing clinical improvement with
{"title":"Diclofenac Induced Rapidly Progressive Renal Failure in Elderly Patient – A Case Report","authors":"C. C., Srirangam Anusha, K. H B","doi":"10.5530/ijopp.15.4.56","DOIUrl":"https://doi.org/10.5530/ijopp.15.4.56","url":null,"abstract":"(RPRF) Rapidly progressive renal failure is categorized by a rapid loss of kidney functions over days to weeks. Acute kidney injury is a sudden episode of kidney failure or kidney damage that happens within a few hours to days. Non-Steroidal Anti-Inflammatory Drugs and/or acetaminophen are commonly used in mild to moderate pain management. NSAID and/or acetaminophen have been reported to cause reversible acute renal failure. A 68-year-old male patient brought with the chief complaints on admission of vomiting, breathlessness since 4 days, pain in the abdomen since 5 days, burning sensation in chest, burning micturition, haematuria since 2 weeks. He was a known case of wind-swept deformity and receiving combination of Tablet Diclofenac sodium 50 mg/Acetaminophen 500 mg once a day in the past 8 years for knee pain. He was diagnosed with Rapidly Progressive Renal Failure-Acute Kidney Injury, Contrast induced Nephropathy, Bladder Outlet Obstruction. The laboratory investigations show abnormality in the serum creatinine, blood urea, haematological parameters indicate normocytic normochromic anaemia with neutrophilic leucocytosis. In the assessment of this case it was found that Diclofenac/Acetaminophen has induced Rapidly Progressive Renal Failure. After withdrawal of Diclofenac/Acetaminophen all the values returned within the normal range and his oedema was also subsiding, showing clinical improvement with","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"149 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77584332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Goutham Retheesh, B. Joseph, Kavya Surendran, J. Vilapurathu
Since the incidence of adverse events associated with the use of class of diuretics, named loop diuretics are increasing per subject, this study was found to be significant. The aim or hypothesis of the study was to monitor the associated complications like Arrhythmia, hyponatremia or Renal dysfunction and to study about the side effect profile of loop diuretics used in the treatment of ADHF/LVF patients; both adverse events and adverse drug effects. The study is a Single-Centered, Retrospective Observational Study and was designed in the Cardiology and Nephrology Departments of a tertiary care hospital. Data were collected from the medical records. Then those were analysed in detail as well as statistically for obtaining and intervening the results. Hypokalemia, Hyponatremia, Renal dysfunction, Cardiorenal dysregulation etc. were the major complications. About the adverse event, Arrhythmia occurred in 97 patients (38.04%), 115 patients (45.10%) resulted in Hyponatremia and acute Kidney Injury has occurred in 43(16.86%) of patients. Regarding adverse drug reactions as a result of diuretic use can be classified as allergic rashes, abdominal discomfort, edema, vomiting, diarrhoea, constipation, muscle spasm, restlessness. The most common adverse event observed was allergic rashes 24 (58.54%) followed by abdominal discomfort 5 (12.20%). The study reveals that states that non-potassium sparing diuretics have an increased risk of adverse event associated death in HF patients whereas, potassium supplementation improved the outcomes.
{"title":"A Retrospective Study to Determine the Side Effects and Complications Associated with the Usage of Loop Diuretics in ADHF or Left Ventricular Heart Failure Patients","authors":"Goutham Retheesh, B. Joseph, Kavya Surendran, J. Vilapurathu","doi":"10.5530/ijopp.15.4.48","DOIUrl":"https://doi.org/10.5530/ijopp.15.4.48","url":null,"abstract":"Since the incidence of adverse events associated with the use of class of diuretics, named loop diuretics are increasing per subject, this study was found to be significant. The aim or hypothesis of the study was to monitor the associated complications like Arrhythmia, hyponatremia or Renal dysfunction and to study about the side effect profile of loop diuretics used in the treatment of ADHF/LVF patients; both adverse events and adverse drug effects. The study is a Single-Centered, Retrospective Observational Study and was designed in the Cardiology and Nephrology Departments of a tertiary care hospital. Data were collected from the medical records. Then those were analysed in detail as well as statistically for obtaining and intervening the results. Hypokalemia, Hyponatremia, Renal dysfunction, Cardiorenal dysregulation etc. were the major complications. About the adverse event, Arrhythmia occurred in 97 patients (38.04%), 115 patients (45.10%) resulted in Hyponatremia and acute Kidney Injury has occurred in 43(16.86%) of patients. Regarding adverse drug reactions as a result of diuretic use can be classified as allergic rashes, abdominal discomfort, edema, vomiting, diarrhoea, constipation, muscle spasm, restlessness. The most common adverse event observed was allergic rashes 24 (58.54%) followed by abdominal discomfort 5 (12.20%). The study reveals that states that non-potassium sparing diuretics have an increased risk of adverse event associated death in HF patients whereas, potassium supplementation improved the outcomes.","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89853632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sharmila Nirojini P, D. V, Dahlia Dixcy S, Bharathi J, A. A, Anjana Ag
{"title":"Dengue Shock Syndrome - A Case Report","authors":"Sharmila Nirojini P, D. V, Dahlia Dixcy S, Bharathi J, A. A, Anjana Ag","doi":"10.5530/ijopp.15.4.57","DOIUrl":"https://doi.org/10.5530/ijopp.15.4.57","url":null,"abstract":"","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82346905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Syed Z. Inamdar, S. Londhe, Ravina Mehta, Sumanyu Katageri, Siddanagouda M Biradar, Shashidhar Devaramani, S. Badiger
Systemic sclerosis is a rare connective tissue disease categorized by extensive lung fibrosis, vascular and immunologic abnormalities. Autoimmune antibodies like anticentromere, anti-Scl-70 (anti-topoisomerase I), and anti-RNA polymerase II are commonly involved in progressive disease. Clinical presentations consist of Raynaud’s phenomenon, digital ulcers; pericardial effusion, and telangiectasia and are mostly associated with pulmonary complications like interstitial lung disease and pulmonary arterial hypertension. Disease-specific therapy is unavailable instead; symptomatic management is only the line of treatment. We report here a case of diffuse systemic sclerosis with interstitial lung disease and pulmonary arterial hypertension.
{"title":"Diffuse Systemic Sclerosis with Interstitial Lung Disease and Severe Pulmonary Arterial Hypertension: A Case Report","authors":"Syed Z. Inamdar, S. Londhe, Ravina Mehta, Sumanyu Katageri, Siddanagouda M Biradar, Shashidhar Devaramani, S. Badiger","doi":"10.5530/ijopp.15.4.62","DOIUrl":"https://doi.org/10.5530/ijopp.15.4.62","url":null,"abstract":"Systemic sclerosis is a rare connective tissue disease categorized by extensive lung fibrosis, vascular and immunologic abnormalities. Autoimmune antibodies like anticentromere, anti-Scl-70 (anti-topoisomerase I), and anti-RNA polymerase II are commonly involved in progressive disease. Clinical presentations consist of Raynaud’s phenomenon, digital ulcers; pericardial effusion, and telangiectasia and are mostly associated with pulmonary complications like interstitial lung disease and pulmonary arterial hypertension. Disease-specific therapy is unavailable instead; symptomatic management is only the line of treatment. We report here a case of diffuse systemic sclerosis with interstitial lung disease and pulmonary arterial hypertension.","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"1 11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78515307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Pelluri, Monikasurya Thummapudi, Harika Paritala, Thota Sai Kiran Kumar, Raziya Sulthana, Chinta Indu Radha, Madhuri Chandu, Sai Susmitha Rebba, Amrut Kara, Geethika Rayapati, Prudhvi Sai Velavarthipati, Sruthi Doddapaneni, S. Puttagunta
{"title":"Assessment of Knowledge, Attitude and Practice towards Dispensing of Antibiotics and Over the Counter Drugs among Community Pharmacists in Guntur, Andhra Pradesh","authors":"R. Pelluri, Monikasurya Thummapudi, Harika Paritala, Thota Sai Kiran Kumar, Raziya Sulthana, Chinta Indu Radha, Madhuri Chandu, Sai Susmitha Rebba, Amrut Kara, Geethika Rayapati, Prudhvi Sai Velavarthipati, Sruthi Doddapaneni, S. Puttagunta","doi":"10.5530/ijopp.15.4.49","DOIUrl":"https://doi.org/10.5530/ijopp.15.4.49","url":null,"abstract":"","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85161247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atul Desai, K. Desai, Hemshree Desai, R. Desai, Chirag V Desai, Pinky Purohit, Nikita Champaneri, A. Patel, Pragna Mahida
{"title":"Case Report Study of Integrated Treatment with T-AYU-HM Premium in a Child of Sickle Cell Disease: A 7 Year Follow up Study","authors":"Atul Desai, K. Desai, Hemshree Desai, R. Desai, Chirag V Desai, Pinky Purohit, Nikita Champaneri, A. Patel, Pragna Mahida","doi":"10.5530/ijopp.15.4.59","DOIUrl":"https://doi.org/10.5530/ijopp.15.4.59","url":null,"abstract":"","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82137764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Okoro, E. W. Hedima, Siyaka Abdullateef, C. Aguiyi-Ikeanyi, Steward Mudenda
{"title":"Ethics of Pharmacy Practice: Ethical Principles Knowledge and Perceived Ethical Practices of Community and Hospital Pharmacists in Nigeria","authors":"R. Okoro, E. W. Hedima, Siyaka Abdullateef, C. Aguiyi-Ikeanyi, Steward Mudenda","doi":"10.5530/ijopp.15.4.55","DOIUrl":"https://doi.org/10.5530/ijopp.15.4.55","url":null,"abstract":"","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88119816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Viswa S, Roshny A, Naveen Kumar B, L. Babu, A. S., S. N.
{"title":"Correlation between Non-communicable Diseases and Curcumin Use","authors":"Viswa S, Roshny A, Naveen Kumar B, L. Babu, A. S., S. N.","doi":"10.5530/ijopp.15.4.50","DOIUrl":"https://doi.org/10.5530/ijopp.15.4.50","url":null,"abstract":"","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76651503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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