Abstract: Drug information services are of prime importance in delivering optimal drug therapies by providing specific and unbiased information to healthcare professionals. Present work has been undertaken to evaluate the pattern of various drug information queries received by the drug information center in a tertiary care hospital. A total of 593 drug information queries that were received during the period were evaluated retrospectively. Upon assessment, it was found that most of the beneficiaries of the service were physicians (51%). Greater numbers of queries received were to update knowledge (71.27%), followed by better patient care (28.72%). Most of the queries are received during ward rounds (71.63%). The types of queries received were categorically related to drug profile (6.75%), dosage information (3.71%), drug indication (13.49%), adverse effects (21.42%), the pharmacokinetics of drug (3.37%), pharmacotherapy (4.05%), drug interactions (1.52%), mechanism of action (11.30%), pharmacotherapy (4.05%) and poison information (0.17%). The source of reference for response to the query is mainly electronic databases (50.59%), secondary (21.08%), and tertiary sources (16.86%). The drug information services provided by the pharmacy practice cater to the healthcare services’ needs for better patient care and updated knowledge. Moreover, these services will help the medical professional to prefer appropriate medicine in the management of the disease, thereby improving the treatment outcomes and patients’ quality of life. Key words: Drug Information, Drug Information Services, Drug Query, Knowledge Update.
{"title":"Evaluation of Drug Information Services in a Tertiary Care Hospital","authors":"Syed Zia Inamdar, Sushil Kumar Londhe, Sumanyu Kategri, Raghavendra Kulkarni, Sharan Badiger, Siddanagouda Biradar","doi":"10.5530/ijopp.16.4.60","DOIUrl":"https://doi.org/10.5530/ijopp.16.4.60","url":null,"abstract":"Abstract: Drug information services are of prime importance in delivering optimal drug therapies by providing specific and unbiased information to healthcare professionals. Present work has been undertaken to evaluate the pattern of various drug information queries received by the drug information center in a tertiary care hospital. A total of 593 drug information queries that were received during the period were evaluated retrospectively. Upon assessment, it was found that most of the beneficiaries of the service were physicians (51%). Greater numbers of queries received were to update knowledge (71.27%), followed by better patient care (28.72%). Most of the queries are received during ward rounds (71.63%). The types of queries received were categorically related to drug profile (6.75%), dosage information (3.71%), drug indication (13.49%), adverse effects (21.42%), the pharmacokinetics of drug (3.37%), pharmacotherapy (4.05%), drug interactions (1.52%), mechanism of action (11.30%), pharmacotherapy (4.05%) and poison information (0.17%). The source of reference for response to the query is mainly electronic databases (50.59%), secondary (21.08%), and tertiary sources (16.86%). The drug information services provided by the pharmacy practice cater to the healthcare services’ needs for better patient care and updated knowledge. Moreover, these services will help the medical professional to prefer appropriate medicine in the management of the disease, thereby improving the treatment outcomes and patients’ quality of life. Key words: Drug Information, Drug Information Services, Drug Query, Knowledge Update.","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akbar Md Akbar, Deepak Jha, Hasan Ali, Tasneem Ahmad
Abstract: Cardiovascular Disease (CVD) remains a global health concern, with dyslipidemia playing a significant role in its development. Traditional approaches to assessing CVD risk have primarily focused on individual lipid components, notably Low-Density Lipoprotein cholesterol (LDL-c). However, these approaches exhibit limitations, particularly when applied to populations with hypertriglyceridemia and metabolic disorders. An alternative, non-High-Density Lipoprotein cholesterol (non-HDL-c), which is calculated as the difference between total cholesterol and High-Density Lipoprotein cholesterol (HDL-c), has emerged as a superior biomarker for evaluating CVD risk. Non-HDL-c encompasses all lipoproteins associated with atherosclerosis, including those rich in triglycerides, offering a more comprehensive perspective on atherogenic burden. This biomarker possesses several advantages, including a robust correlation with atherosclerosis, consistent measurements under diverse laboratory conditions, and suitability for non-fasting samples. Most importantly, non-HDL-c exhibits superior predictive capabilities for cardiovascular events when compared to LDL-c. This review underscores the evolution of lipid assessment, elucidates the pathophysiological foundations of non-HDL-c, and underscores its central role in contemporary cardiovascular risk evaluation. Furthermore, it delves into the potential of non-HDL-c in guiding treatment decisions and enhancing patient outcomes, thus emphasizing its crucial role in the battle against CVD. Keywords: Cardiovascular disease, Dyslipidemia, Non-high-density lipoprotein cholesterol, Atherosclerosis, Risk assessment, Cholesterol management.
{"title":"Non-HDL Estimation Methods: Advancing Cardiovascular Disease Prediction","authors":"Akbar Md Akbar, Deepak Jha, Hasan Ali, Tasneem Ahmad","doi":"10.5530/ijopp.16.4.52","DOIUrl":"https://doi.org/10.5530/ijopp.16.4.52","url":null,"abstract":"Abstract: Cardiovascular Disease (CVD) remains a global health concern, with dyslipidemia playing a significant role in its development. Traditional approaches to assessing CVD risk have primarily focused on individual lipid components, notably Low-Density Lipoprotein cholesterol (LDL-c). However, these approaches exhibit limitations, particularly when applied to populations with hypertriglyceridemia and metabolic disorders. An alternative, non-High-Density Lipoprotein cholesterol (non-HDL-c), which is calculated as the difference between total cholesterol and High-Density Lipoprotein cholesterol (HDL-c), has emerged as a superior biomarker for evaluating CVD risk. Non-HDL-c encompasses all lipoproteins associated with atherosclerosis, including those rich in triglycerides, offering a more comprehensive perspective on atherogenic burden. This biomarker possesses several advantages, including a robust correlation with atherosclerosis, consistent measurements under diverse laboratory conditions, and suitability for non-fasting samples. Most importantly, non-HDL-c exhibits superior predictive capabilities for cardiovascular events when compared to LDL-c. This review underscores the evolution of lipid assessment, elucidates the pathophysiological foundations of non-HDL-c, and underscores its central role in contemporary cardiovascular risk evaluation. Furthermore, it delves into the potential of non-HDL-c in guiding treatment decisions and enhancing patient outcomes, thus emphasizing its crucial role in the battle against CVD. Keywords: Cardiovascular disease, Dyslipidemia, Non-high-density lipoprotein cholesterol, Atherosclerosis, Risk assessment, Cholesterol management.","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saba Farooqui, Puja Kundu, Sandra Simon, Savitha Amin, Sajan Francis P, Scandashree Krishnegowda
Abstract: Introduction: Hemodialysis patients have specific medical needs and challenges due to their renal failure and the need for regular dialysis treatment. These patients often experience significant physical, emotional, and social burdens associated with their condition. Studying this population can provide useful insights on the impact of drug use and its effects on their quality of life. Researchers can identify opportunities to optimise prescription regimens, eliminate side effects, and improve overall well-being by analysing the impact of drug use on their quality of life. Materials and Methods: Over the six-month period from May 2022 to October 2022, we conducted an observational and cross-sectional study on 100 patients who were admitted to the hemodialysis unit of a tertiary care teaching hospital. A well-designed data collecting form was used in conjunction with the KDQoL-36 questionnaire to record all the necessary information. Results: In a study involving 100 hemodialysis patients, it was found that 96% had co-morbidities. A total of 761 medications were prescribed, with 22.87% for female patients and 77.13% for male patients. Adverse drug reactions were observed in 52% of cases, with hyponatremia, hypokalemia, and hypoglycemia being the most common. Patients generally had an average quality of life, but some experienced below-average quality. There was a significant difference between men and women in the Physical Health component. Dry mouth and anorexia were prevalent, and adherence to food and drink limits was challenging. Cramping occurred in 62% of patients after dialysis. Patients scored worse in the physical component compared to the mental component. Conclusion: This study recognized the diversity of medications in hemodialysis patients. In conclusion, this study found that hemodialysis patients had a significant prevalence of co-morbidities, with the majority having an average quality of life. Adverse medication reactions were widespread, including hyponatraemia and hypokalaemia. Gender disparities in the physical health component were discovered. The findings of this study urge the hemodialysis unit’s practioners to create educational initiatives to raise standard of living. Keywords: Prescribing pattern, Health-related quality of life, Hemodialysis, Drug Utilization Evaluation.
{"title":"A Study on Drug Utilization Evaluation and Health-Related Quality of Life in Hemodialysis Patients","authors":"Saba Farooqui, Puja Kundu, Sandra Simon, Savitha Amin, Sajan Francis P, Scandashree Krishnegowda","doi":"10.5530/ijopp.16.4.55","DOIUrl":"https://doi.org/10.5530/ijopp.16.4.55","url":null,"abstract":"Abstract: Introduction: Hemodialysis patients have specific medical needs and challenges due to their renal failure and the need for regular dialysis treatment. These patients often experience significant physical, emotional, and social burdens associated with their condition. Studying this population can provide useful insights on the impact of drug use and its effects on their quality of life. Researchers can identify opportunities to optimise prescription regimens, eliminate side effects, and improve overall well-being by analysing the impact of drug use on their quality of life. Materials and Methods: Over the six-month period from May 2022 to October 2022, we conducted an observational and cross-sectional study on 100 patients who were admitted to the hemodialysis unit of a tertiary care teaching hospital. A well-designed data collecting form was used in conjunction with the KDQoL-36 questionnaire to record all the necessary information. Results: In a study involving 100 hemodialysis patients, it was found that 96% had co-morbidities. A total of 761 medications were prescribed, with 22.87% for female patients and 77.13% for male patients. Adverse drug reactions were observed in 52% of cases, with hyponatremia, hypokalemia, and hypoglycemia being the most common. Patients generally had an average quality of life, but some experienced below-average quality. There was a significant difference between men and women in the Physical Health component. Dry mouth and anorexia were prevalent, and adherence to food and drink limits was challenging. Cramping occurred in 62% of patients after dialysis. Patients scored worse in the physical component compared to the mental component. Conclusion: This study recognized the diversity of medications in hemodialysis patients. In conclusion, this study found that hemodialysis patients had a significant prevalence of co-morbidities, with the majority having an average quality of life. Adverse medication reactions were widespread, including hyponatraemia and hypokalaemia. Gender disparities in the physical health component were discovered. The findings of this study urge the hemodialysis unit’s practioners to create educational initiatives to raise standard of living. Keywords: Prescribing pattern, Health-related quality of life, Hemodialysis, Drug Utilization Evaluation.","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Subadradevi Subadradevi J, Vishnupriya Vishnupriya S, Jasmine Fathima A, Indhu Priyadarshini M
Abstract: Background: A pharmacist is an individual who involved in designing, manufacturing, dispensing, managing and planning of a pharmaceutical care plan. Inside a professional network of patients and pharmacists, pharmacists are expected more for providing pharmaceutical care. It’s commonly accepted that the public satisfaction is an essential part in the quality of health care. Unless the patients or public properly understand the professional roles of pharmacist related to patient care activities, the proper and better pharmaceutical care implementation cannot be attained. Aim: This survey was planned to conduct with the main aim to determine the knowledge and perception of society towards the roles, responsibilities along with various services provided by the pharmacists. Materials and Methods: Based on inclusion criteria 1000 people were included in this study. After giving their consent, survey questionnaires were answered by the people on their own. Results: In that majority of the people (45.2%) agreed and 22.9%. of people strongly agreed that the pharmacist having important role in health care system. Conclusion: This study represents that most of the people (45.2% + 22.6% = 68.1%) know the important roles of pharmacists and indicates that general public having positive perception and knowledge about the various roles of pharmacist in healthcare system. Keywords: Pharmacist Perception, Knowledge, Health care system.
{"title":"Public Knowledge and Perception towards the Roles of Pharmacists in Health Care System: A Quantitative Survey Study","authors":"Subadradevi Subadradevi J, Vishnupriya Vishnupriya S, Jasmine Fathima A, Indhu Priyadarshini M","doi":"10.5530/ijopp.16.4.59","DOIUrl":"https://doi.org/10.5530/ijopp.16.4.59","url":null,"abstract":"Abstract: Background: A pharmacist is an individual who involved in designing, manufacturing, dispensing, managing and planning of a pharmaceutical care plan. Inside a professional network of patients and pharmacists, pharmacists are expected more for providing pharmaceutical care. It’s commonly accepted that the public satisfaction is an essential part in the quality of health care. Unless the patients or public properly understand the professional roles of pharmacist related to patient care activities, the proper and better pharmaceutical care implementation cannot be attained. Aim: This survey was planned to conduct with the main aim to determine the knowledge and perception of society towards the roles, responsibilities along with various services provided by the pharmacists. Materials and Methods: Based on inclusion criteria 1000 people were included in this study. After giving their consent, survey questionnaires were answered by the people on their own. Results: In that majority of the people (45.2%) agreed and 22.9%. of people strongly agreed that the pharmacist having important role in health care system. Conclusion: This study represents that most of the people (45.2% + 22.6% = 68.1%) know the important roles of pharmacists and indicates that general public having positive perception and knowledge about the various roles of pharmacist in healthcare system. Keywords: Pharmacist Perception, Knowledge, Health care system.","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"83 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract: Background: Diabetes is a chronic, disease with life altering consequences, which effects virtually every organ in the human system. Co-existence of psychological symptoms and DM becomes a grave challenge for the clinicians as both illnesses worsen the outcomes. Depression/ Anxiety is one of the raising causes of seeking health care. Presence of psychiatric symptoms seriously impairs the health-related quality of life among diabetic patients. Psychiatric symptoms can decrease adherence to self-care practices, contributing to higher HbA1c levels. Individuals with diabetes are having 2 to 4 times greater risk of psychological distress when compared to individuals without diabetes. Materials and Methods: This prospective, observational study was conducted in the department of Psychiatry 150 patients were enrolled into the study who attended the outpatient department. Discussion: Among 150 subjects, majority of the study subjects 119 (79%) were found to be anxiety condition than depression at the time of assessment. The subjects with depression were found to be 28 (17%) The presence of depression among subjects who are taking Insulin, OHA, both were found to be 11.5%, 4.6% and 1% respectively. The distribution of anxiety in subjects who are taking Insulin, OHA, both were found to be 8%, 51.3% and 19.3% respectively. Conclusion: The study found a high proportion of anxiety among patients with T2DM.Therefore the care of individuals with DM should include the screening and possible treatment of anxiety in order to achieve and sustain treatment goals. Keywords: Diabetes mellitus, Depression, Anxiety, Insulin, Oral hypoglycaemics, Psychiatric illness, Stress, HbA1c, Fasting blood glucose level, Post prandial blood glucose level.
{"title":"Psychiatric Morbidity and its Correlations in Diabetic Patients in a Tertiary Care Hospital","authors":"Kurupatha Menatha Jayasree, Sirisha Stephen, Kottedi Haritha, Pathan Humerakhan, Ganesh Kumar","doi":"10.5530/ijopp.16.4.53","DOIUrl":"https://doi.org/10.5530/ijopp.16.4.53","url":null,"abstract":"Abstract: Background: Diabetes is a chronic, disease with life altering consequences, which effects virtually every organ in the human system. Co-existence of psychological symptoms and DM becomes a grave challenge for the clinicians as both illnesses worsen the outcomes. Depression/ Anxiety is one of the raising causes of seeking health care. Presence of psychiatric symptoms seriously impairs the health-related quality of life among diabetic patients. Psychiatric symptoms can decrease adherence to self-care practices, contributing to higher HbA1c levels. Individuals with diabetes are having 2 to 4 times greater risk of psychological distress when compared to individuals without diabetes. Materials and Methods: This prospective, observational study was conducted in the department of Psychiatry 150 patients were enrolled into the study who attended the outpatient department. Discussion: Among 150 subjects, majority of the study subjects 119 (79%) were found to be anxiety condition than depression at the time of assessment. The subjects with depression were found to be 28 (17%) The presence of depression among subjects who are taking Insulin, OHA, both were found to be 11.5%, 4.6% and 1% respectively. The distribution of anxiety in subjects who are taking Insulin, OHA, both were found to be 8%, 51.3% and 19.3% respectively. Conclusion: The study found a high proportion of anxiety among patients with T2DM.Therefore the care of individuals with DM should include the screening and possible treatment of anxiety in order to achieve and sustain treatment goals. Keywords: Diabetes mellitus, Depression, Anxiety, Insulin, Oral hypoglycaemics, Psychiatric illness, Stress, HbA1c, Fasting blood glucose level, Post prandial blood glucose level.","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sri Jahnavi Adusumilli, Hari Sai Gnana Lakshmi Gadu, Devi Priyanka Marni, Sri Raghu Bapiraju Mudunuri
Abstract: Objectives: To evaluate the effectiveness and safety of different COVID-19 vaccines approved by CDSCO. The aim is to assess the safety and efficacy of COVID-19 vaccines through a questionnaire-based cross-sectional study. Materials and Methods: The Cross-Sectional Observational study has been carried out through a questionnaire-based survey followed by a telephonic interview. Microsoft Excel and GraphPad Prism version 9.3.1 were accessed to examine the statistics. Chi-square, Kruskal-Walli’s, and Mann-Whitney tests were accessed to assess the effect of categorical variables, one independent variable on two or more dependent variables, and 2 independent groups respectively. Results: Significant difference seen between marital status and COVID infection status, age, and vaccination status. The older the age, number of vaccines taken increases. Significant differences were seen between age and severity of side effects. High-age people have less severe side effects. Vaccinated people were less infected with COVID-19 infection. Significant differences were seen between age and Covid infection status. Low-age people were less infected. Conclusion: In our study, 37.38% weren’t infected. Among the infected 65.69% were before vaccination, 10.51% after the first dose and before the second dose, 20.22% after the second dose, 1.94% after the booster dose, and 1.61% both before and after vaccination. 41.86% experienced side effects like fever, pain at the injection site, body pains, and headache. Side effects being temporary only a few had to stop by a physician or taken to the infirmary. So, we conclude COVID-19 vaccines have shown better efficacy and safety. Keywords: SARS-CoV-2, COVID-19, AEFIn, CDSCO.
{"title":"Assessment of Efficacy and Safety Associated with COVID-19 Vaccines: A Questionnaire Based Cross-Sectional Study","authors":"Sri Jahnavi Adusumilli, Hari Sai Gnana Lakshmi Gadu, Devi Priyanka Marni, Sri Raghu Bapiraju Mudunuri","doi":"10.5530/ijopp.16.4.61","DOIUrl":"https://doi.org/10.5530/ijopp.16.4.61","url":null,"abstract":"Abstract: Objectives: To evaluate the effectiveness and safety of different COVID-19 vaccines approved by CDSCO. The aim is to assess the safety and efficacy of COVID-19 vaccines through a questionnaire-based cross-sectional study. Materials and Methods: The Cross-Sectional Observational study has been carried out through a questionnaire-based survey followed by a telephonic interview. Microsoft Excel and GraphPad Prism version 9.3.1 were accessed to examine the statistics. Chi-square, Kruskal-Walli’s, and Mann-Whitney tests were accessed to assess the effect of categorical variables, one independent variable on two or more dependent variables, and 2 independent groups respectively. Results: Significant difference seen between marital status and COVID infection status, age, and vaccination status. The older the age, number of vaccines taken increases. Significant differences were seen between age and severity of side effects. High-age people have less severe side effects. Vaccinated people were less infected with COVID-19 infection. Significant differences were seen between age and Covid infection status. Low-age people were less infected. Conclusion: In our study, 37.38% weren’t infected. Among the infected 65.69% were before vaccination, 10.51% after the first dose and before the second dose, 20.22% after the second dose, 1.94% after the booster dose, and 1.61% both before and after vaccination. 41.86% experienced side effects like fever, pain at the injection site, body pains, and headache. Side effects being temporary only a few had to stop by a physician or taken to the infirmary. So, we conclude COVID-19 vaccines have shown better efficacy and safety. Keywords: SARS-CoV-2, COVID-19, AEFIn, CDSCO.","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"876 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract: Drug-induced interstitial lung disease is an increasingly common cause of morbidity and mortality. Nitrofurantoin is a broad-spectrum antibiotic used for acute uncomplicated or simple cystitis as well as for prophylaxis of recurrent infection. We recently encountered a case of Nitrofurantoin-induced interstitial lung disease in an elderly patient who was on Nitrofurantoin for a year and a half for recurrent urinary tract infections. On further evaluation, she was diagnosed with drug-induced interstitial lung disease, which was confirmed by radiographic evidence. Nitrofurantoin was discontinued and managed with low-dose systemic glucocorticoids. This case report highlights the need for close vigilance of pulmonary toxicities in patients taking long-term Nitrofurantoin therapy. Keywords: Pulmonary toxicity, Corticosteroids, Nitrofurantoin, Interstitial Lung disease, Urinary tract infection.
{"title":"Nitrofurantoin Induced Reversible Interstitial Lung Disease","authors":"Shabana Ashraf, Sajid Salahudheen","doi":"10.5530/ijopp.16.4.63","DOIUrl":"https://doi.org/10.5530/ijopp.16.4.63","url":null,"abstract":"Abstract: Drug-induced interstitial lung disease is an increasingly common cause of morbidity and mortality. Nitrofurantoin is a broad-spectrum antibiotic used for acute uncomplicated or simple cystitis as well as for prophylaxis of recurrent infection. We recently encountered a case of Nitrofurantoin-induced interstitial lung disease in an elderly patient who was on Nitrofurantoin for a year and a half for recurrent urinary tract infections. On further evaluation, she was diagnosed with drug-induced interstitial lung disease, which was confirmed by radiographic evidence. Nitrofurantoin was discontinued and managed with low-dose systemic glucocorticoids. This case report highlights the need for close vigilance of pulmonary toxicities in patients taking long-term Nitrofurantoin therapy. Keywords: Pulmonary toxicity, Corticosteroids, Nitrofurantoin, Interstitial Lung disease, Urinary tract infection.","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Madaiah Kumaraswamy, Akshay Mohan, Thanveer Ahammed Chonari, Muhammed Dahim
Abstract: Adverse Drug Reactions (ADRs) tools are very significant in the detection, assessment, and severity of ADRs. This review emphasizes the most frequently utilized causality assessment scales, for example, the WHO-Uppsala Monitoring Centre Causality Assessment System, the Naranjo algorithm for the ADR assessment, the Liverpool Causality Assessment Tool (LCAT), and the Roussel Uclaf Causality Assessment Method (RUCAM). Bayesian Adverse Reactions Diagnostic Instrument (BARDI). In this review we found that the most commonly preferred tool is Naranjo Algorithm and the most commonly used combination is the WHO-Uppsala Monitoring Centre causality assessment system and the Naranjo algorithm. Large numbers of causality appraisal strategies have their benefits and burdens. In any case, Due to variation and inconsistency, no single causality assessment measure has been accepted and utilised globally. No single scale, however, has been accepted as standardised and taken into consideration for widespread acceptability. Keywords: Adverse Drug Reaction, Causality assessment tools, Naranjo algorithm, WHO-Uppsala Monitoring Centre causality assessment system.
{"title":"Adverse Drug Reaction Tools Used in Causality Assessment","authors":"Madaiah Kumaraswamy, Akshay Mohan, Thanveer Ahammed Chonari, Muhammed Dahim","doi":"10.5530/ijopp.16.4.50","DOIUrl":"https://doi.org/10.5530/ijopp.16.4.50","url":null,"abstract":"Abstract: Adverse Drug Reactions (ADRs) tools are very significant in the detection, assessment, and severity of ADRs. This review emphasizes the most frequently utilized causality assessment scales, for example, the WHO-Uppsala Monitoring Centre Causality Assessment System, the Naranjo algorithm for the ADR assessment, the Liverpool Causality Assessment Tool (LCAT), and the Roussel Uclaf Causality Assessment Method (RUCAM). Bayesian Adverse Reactions Diagnostic Instrument (BARDI). In this review we found that the most commonly preferred tool is Naranjo Algorithm and the most commonly used combination is the WHO-Uppsala Monitoring Centre causality assessment system and the Naranjo algorithm. Large numbers of causality appraisal strategies have their benefits and burdens. In any case, Due to variation and inconsistency, no single causality assessment measure has been accepted and utilised globally. No single scale, however, has been accepted as standardised and taken into consideration for widespread acceptability. Keywords: Adverse Drug Reaction, Causality assessment tools, Naranjo algorithm, WHO-Uppsala Monitoring Centre causality assessment system.","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract: Cornelia de Lange disorder (CdLS) may be an intrinsic condition stamped by a characteristic facial appearance, pre-birth and postnatal development lacking, eating challenges, psychomotor delay, behavioral clutters, and concomitant upper limit distortions. W. Brachmann archived the primary case of CdLS in 1916, taken after Cornelia de Lange, a Dutch pediatrician, in 1933, after whom the clutter was named. In any case, not each individual with CdLS has the normal phenotype and can show in an assortment of ways, extending from gentle to severe and with shifting degrees of confront and appendage inclusion. The essential instrument behind CdLS has been hypothesized to be dysregulated quality expression. Surgery may be used to treat diaphragmatic hernias, heart anomalies, and/or cleft sense of taste in a few children. Over-the-top hair development could be decreased with plastic surgery. Keywords: Cornelia de Lange syndrome, Brachmann-de Lange syndrome, Craniofacial, Synophrys, Micrognathia.
摘要/ Abstract摘要:Cornelia de Lange disorder (CdLS)可能是一种以面部特征、产前和产后发育缺乏、饮食困难、精神运动迟缓、行为混乱以及伴随的上限扭曲为特征的内在疾病。1916年，w·勃拉赫曼(W. Brachmann)以荷兰儿科医生科妮莉亚·德·兰格(Cornelia de Lange)的名字命名了CdLS的第一例病例，并于1933年将其存档。在任何情况下，并不是每个CdLS患者都有正常的表型，并且可以以各种方式表现出来，从轻微到严重，并随着对抗和附属物的变化程度而变化。CdLS背后的基本工具被假设为失调的质量表达。手术可用于治疗膈疝，心脏异常，和/或味觉裂在少数儿童。通过整形手术可以减少头发的过度生长。关键词:Cornelia de Lange综合征，Brachmann-de Lange综合征，颅面，Synophrys，小颌畸形
{"title":"Cornelia de Lange Syndrome: A Chronicle Review","authors":"Sumithra Devadiga, Adarsh Adarsh VV, Bhagyashree Bhagyashree S, Bhagyashree Bhagyashree S, Savitha Savitha S, Ravikumar Nayak","doi":"10.5530/ijopp.16.4.51","DOIUrl":"https://doi.org/10.5530/ijopp.16.4.51","url":null,"abstract":"Abstract: Cornelia de Lange disorder (CdLS) may be an intrinsic condition stamped by a characteristic facial appearance, pre-birth and postnatal development lacking, eating challenges, psychomotor delay, behavioral clutters, and concomitant upper limit distortions. W. Brachmann archived the primary case of CdLS in 1916, taken after Cornelia de Lange, a Dutch pediatrician, in 1933, after whom the clutter was named. In any case, not each individual with CdLS has the normal phenotype and can show in an assortment of ways, extending from gentle to severe and with shifting degrees of confront and appendage inclusion. The essential instrument behind CdLS has been hypothesized to be dysregulated quality expression. Surgery may be used to treat diaphragmatic hernias, heart anomalies, and/or cleft sense of taste in a few children. Over-the-top hair development could be decreased with plastic surgery. Keywords: Cornelia de Lange syndrome, Brachmann-de Lange syndrome, Craniofacial, Synophrys, Micrognathia.","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Riya Sharma, Aman Thakur, Amit Sharma, Mandeep Kaur, Yousef Saeed Alqarni, Fahad T Alsulami
Abstract: Background and Objectives: The medication regimens used by patients declared with Coronary Artery Disease (CAD) vary greatly. Our goal was to assess the clinical traits and usage trends in CAD. Assess the factors that influence the occurrence of CAD which ultimately affect the administration of medication in people who have CAD. Materials and Methods: The present prospective research was conducted at the Guru Gobind Singh Medical College and Hospital in Faridkot, Punjab, India, from October 2022 to March 2023 over a six-month period. consent in writing wasn't required from the participants as no direct interaction with the patient was required. The information was gathered using a unique data gathering form, as well as SPSS by IBM Version 26 was used for analysis. Results: The vast majority of the 152 patients were males, accounting for 82 of them as opposed to the 70 female patients. The study's sample's median age ranged from 58 to 69 years. 62.5% of the patients came from rural areas. Only 2% of patients received just one medication, while 68.4% received polypharmacy. The most frequent comorbidity is diabetes and hypertension. Men who drink alcoholic beverages as well as use tobacco products such as cigarettes are more likely to develop CAD. however, most women who refrain from drinking or smoking have been impacted by CAD. Conclusion: The population under study was determined to be inclined to be males, to live in a rural area, as well as be between the ages of 58 and 69. A large proportion of patients received the use of multiple medications (polypharmacy). Keywords: Coronary artery disease, Drug prescribing pattern, Prevalence, Punjab.
摘要:背景与目的:冠心病(CAD)患者的用药方案差异很大。我们的目的是评估CAD的临床特征和使用趋势。评估影响冠心病发生的因素，这些因素最终会影响冠心病患者的用药。材料和方法:本前瞻性研究于2022年10月至2023年3月在印度旁遮普省法里德科特的古鲁·戈宾德·辛格医学院和医院进行，为期六个月。不需要参与者的书面同意，因为不需要与患者直接互动。使用独特的数据收集表格收集信息，并使用IBM Version 26的SPSS软件进行分析。结果:152例患者中男性占绝大多数，占82例，女性占70例。该研究样本的年龄中位数从58岁到69岁不等。62.5%的患者来自农村地区。只有2%的患者只接受一种药物治疗，而68.4%的患者接受多种药物治疗。最常见的合并症是糖尿病和高血压。饮用酒精饮料以及使用烟草产品(如香烟)的男性更有可能患上CAD。然而，大多数不喝酒或不吸烟的女性都受到CAD的影响。结论:研究对象以男性为主，居住在农村地区，年龄在58 - 69岁之间。很大一部分患者接受了多种药物的使用(综合用药)。关键词:冠状动脉疾病，处方模式，患病率，旁遮普
{"title":"Evaluation of Drug Utilization in Patients with Coronary Artery Disease: Prevalence, Predisposing Factors and Prescribing Patterns in Tertiary Care Hospital in Punjab","authors":"Riya Sharma, Aman Thakur, Amit Sharma, Mandeep Kaur, Yousef Saeed Alqarni, Fahad T Alsulami","doi":"10.5530/ijopp.16.4.54","DOIUrl":"https://doi.org/10.5530/ijopp.16.4.54","url":null,"abstract":"Abstract: Background and Objectives: The medication regimens used by patients declared with Coronary Artery Disease (CAD) vary greatly. Our goal was to assess the clinical traits and usage trends in CAD. Assess the factors that influence the occurrence of CAD which ultimately affect the administration of medication in people who have CAD. Materials and Methods: The present prospective research was conducted at the Guru Gobind Singh Medical College and Hospital in Faridkot, Punjab, India, from October 2022 to March 2023 over a six-month period. consent in writing wasn't required from the participants as no direct interaction with the patient was required. The information was gathered using a unique data gathering form, as well as SPSS by IBM Version 26 was used for analysis. Results: The vast majority of the 152 patients were males, accounting for 82 of them as opposed to the 70 female patients. The study's sample's median age ranged from 58 to 69 years. 62.5% of the patients came from rural areas. Only 2% of patients received just one medication, while 68.4% received polypharmacy. The most frequent comorbidity is diabetes and hypertension. Men who drink alcoholic beverages as well as use tobacco products such as cigarettes are more likely to develop CAD. however, most women who refrain from drinking or smoking have been impacted by CAD. Conclusion: The population under study was determined to be inclined to be males, to live in a rural area, as well as be between the ages of 58 and 69. A large proportion of patients received the use of multiple medications (polypharmacy). Keywords: Coronary artery disease, Drug prescribing pattern, Prevalence, Punjab.","PeriodicalId":13495,"journal":{"name":"Indian Journal of Pharmacy Practice","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135889165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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