Case Report, Artur Manasyan, N. Khachikyan, Stephanie Gaytan, Nafiseh Hashemi, J. Ophthalmol, Clin Res, Case Summary
The patient, a 67-year-old female, presented with esotropia, diplopia, and eye redness, as seen in Figure 1. The diplopia started two months prior to the initial visit while the eye started to crossed in. The patient also complained of severe daily headaches along with ringing in her ears. She believes the symptoms started while she was recovering from shingles on her right side of the forehead. Prior MRI imaging was reported to be unremarkable. The patient was referred to neuro-ophthalmology service with possible diagnosis of thyroid eye disease given the red eye and esotropia. Patient had no history of other medical conditions except shingles in trigeminal distribution that occurred about 4-6 weeks before the onset of her symptoms. Central VA was recorded to be unaffected at 20/20 in both eyes with correction. On sensorimotor exam, there was severe horizontal diplopia at the primary, increasing in left, and right gazes due to bilateral VI nerve palsy. Intraocular pressure testing 22mmHg right eye and 19mmHg left eye, indicating ocular hypertension in the right eye. She had corkscrew blood vessels in both eyes. Optical coherence tomography (OCT) revealed normal retinal nerve fiber layer (RNFL) thickness in both eyes.
{"title":"Carotid-Cavernous Fistula: Hemodynamic Dysfunction after Shingles? A Case Report and Review Literature","authors":"Case Report, Artur Manasyan, N. Khachikyan, Stephanie Gaytan, Nafiseh Hashemi, J. Ophthalmol, Clin Res, Case Summary","doi":"10.33140/jocr.06.04.03","DOIUrl":"https://doi.org/10.33140/jocr.06.04.03","url":null,"abstract":"The patient, a 67-year-old female, presented with esotropia, diplopia, and eye redness, as seen in Figure 1. The diplopia started two months prior to the initial visit while the eye started to crossed in. The patient also complained of severe daily headaches along with ringing in her ears. She believes the symptoms started while she was recovering from shingles on her right side of the forehead. Prior MRI imaging was reported to be unremarkable. The patient was referred to neuro-ophthalmology service with possible diagnosis of thyroid eye disease given the red eye and esotropia. Patient had no history of other medical conditions except shingles in trigeminal distribution that occurred about 4-6 weeks before the onset of her symptoms. Central VA was recorded to be unaffected at 20/20 in both eyes with correction. On sensorimotor exam, there was severe horizontal diplopia at the primary, increasing in left, and right gazes due to bilateral VI nerve palsy. Intraocular pressure testing 22mmHg right eye and 19mmHg left eye, indicating ocular hypertension in the right eye. She had corkscrew blood vessels in both eyes. Optical coherence tomography (OCT) revealed normal retinal nerve fiber layer (RNFL) thickness in both eyes.","PeriodicalId":135031,"journal":{"name":"Journal of Ophthalmology & Clinical Research","volume":"157 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128808640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Researc H Article, Hui Liu, Clayton Kirk, Ping Bu, R. Vasaiwala, Jhansi Raju, Charles S. Bouchard, Shaozhen Zhao
Purpose: The purpose of this study was to determine how objective and subjective parameters of dry eye disease correlate with objective vision quality changes following femtosecond laser in-situ keratomileusis (FS-LASIK) surgery in low and high myopes. Methods and Materials: This prospective, observational case series recruited patients undergoing bilateral FS-LASIK. Patients were divided into low/moderate and high myopia groups based on pre-operative assessment. Objective and subjective measurements of dry eye, as well as measurements of vision quality were obtained pre-operatively, 1-week, 1 month, and 3 months post-operatively. Thirty patients were included. The low/moderate and high myopia groups each contained 15 patients. Results: Non-invasive keratography tear break up time (NIKBUT) decreased after FS-LASIK in both groups. Objective scatter index (OSI) improved in the L/M myopia group but worsened in the H myopia group post-operatively. Modulation transfer function (MTF) cutoff improved in both groups post-operatively. A negative correlation was identified between the NIKBUT and both the OSI and MTF results. Changes in ocular surface disease index (OSDI) scores support these objective findings. Conclusion: The results of our study provide evidence that ocular surface changes associated with dry eye contribute to reduced subjective vision quality after FS-LASIK. Refractive surgeons should address dry eye pre-operatively and manage its sequalae post-operatively.
{"title":"Impact of Dry Eye Disease on Visual Function and Quality after Femtosecond LaserAssisted In-Situ Keratomileusis","authors":"Researc H Article, Hui Liu, Clayton Kirk, Ping Bu, R. Vasaiwala, Jhansi Raju, Charles S. Bouchard, Shaozhen Zhao","doi":"10.33140/jocr.06.04.01","DOIUrl":"https://doi.org/10.33140/jocr.06.04.01","url":null,"abstract":"Purpose: The purpose of this study was to determine how objective and subjective parameters of dry eye disease correlate with objective vision quality changes following femtosecond laser in-situ keratomileusis (FS-LASIK) surgery in low and high myopes. Methods and Materials: This prospective, observational case series recruited patients undergoing bilateral FS-LASIK. Patients were divided into low/moderate and high myopia groups based on pre-operative assessment. Objective and subjective measurements of dry eye, as well as measurements of vision quality were obtained pre-operatively, 1-week, 1 month, and 3 months post-operatively. Thirty patients were included. The low/moderate and high myopia groups each contained 15 patients. Results: Non-invasive keratography tear break up time (NIKBUT) decreased after FS-LASIK in both groups. Objective scatter index (OSI) improved in the L/M myopia group but worsened in the H myopia group post-operatively. Modulation transfer function (MTF) cutoff improved in both groups post-operatively. A negative correlation was identified between the NIKBUT and both the OSI and MTF results. Changes in ocular surface disease index (OSDI) scores support these objective findings. Conclusion: The results of our study provide evidence that ocular surface changes associated with dry eye contribute to reduced subjective vision quality after FS-LASIK. Refractive surgeons should address dry eye pre-operatively and manage its sequalae post-operatively.","PeriodicalId":135031,"journal":{"name":"Journal of Ophthalmology & Clinical Research","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132272520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Case Report, Thales AA de Paula, F. Cresta, Milton Ruiz Alves
Purpose: This study aimed to demonstrate the importance of long-term follow-up after corneal collagen crosslinking. Methods: This case report showed an intense progressive flattening of keratometric parameters in a patient without risk factors such as high maximum keratometry, thin cornea, uncontrolled ocular allergy, collagen, or rheumatologic diseases. Even with significant haze formation and progressive flattening, the patient exhibited progression after a long follow-up period. Results: The patient presented with grade 2 haze associated with progressive flattening of approximately 10 D in keratometric parameters (Kmax, K1, K2, and Kmean) during the first 5 years after surgery. Corneal opacity altered the minimum pachymetry reading on Pentacam to 265 microns. Anterior corneal follow-up optical coherence tomography revealed a thickness of 453 microns. The patient developed low visual acuity while wearing glasses. The scleral lens was fitted, allowing a visual acuity of 20/30, with satisfactory visual quality. Keratometric stability was observed between the fifth and tenth year. In the tenth year, the patient maintained haze, but there was a progression of 1.7 D in the Pentacam comparative map. Conclusions: Long-term monitoring after corneal crosslinking should be performed. Eyes with haze and intense progressive flattening may fail after a long period.
{"title":"Progressive Flattening after Corneal Collagen Crosslinking: A 10-Year Follow-Up","authors":"Case Report, Thales AA de Paula, F. Cresta, Milton Ruiz Alves","doi":"10.33140/jocr.06.04.02","DOIUrl":"https://doi.org/10.33140/jocr.06.04.02","url":null,"abstract":"Purpose: This study aimed to demonstrate the importance of long-term follow-up after corneal collagen crosslinking. Methods: This case report showed an intense progressive flattening of keratometric parameters in a patient without risk factors such as high maximum keratometry, thin cornea, uncontrolled ocular allergy, collagen, or rheumatologic diseases. Even with significant haze formation and progressive flattening, the patient exhibited progression after a long follow-up period. Results: The patient presented with grade 2 haze associated with progressive flattening of approximately 10 D in keratometric parameters (Kmax, K1, K2, and Kmean) during the first 5 years after surgery. Corneal opacity altered the minimum pachymetry reading on Pentacam to 265 microns. Anterior corneal follow-up optical coherence tomography revealed a thickness of 453 microns. The patient developed low visual acuity while wearing glasses. The scleral lens was fitted, allowing a visual acuity of 20/30, with satisfactory visual quality. Keratometric stability was observed between the fifth and tenth year. In the tenth year, the patient maintained haze, but there was a progression of 1.7 D in the Pentacam comparative map. Conclusions: Long-term monitoring after corneal crosslinking should be performed. Eyes with haze and intense progressive flattening may fail after a long period.","PeriodicalId":135031,"journal":{"name":"Journal of Ophthalmology & Clinical Research","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122145558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-14DOI: 10.24966/ocr-8887/100098
R. Medalle
Risk factors and disease characteristics of TED cases at EAMC coincide with local published journals, except for significant correlation with male sex and TRAb titers showing the variability of the disease and the need for further studies.
{"title":"Factors Associated with Severe and Active Thyroid-Eye Disease in a Tertiary Hospital Setting","authors":"R. Medalle","doi":"10.24966/ocr-8887/100098","DOIUrl":"https://doi.org/10.24966/ocr-8887/100098","url":null,"abstract":"Risk factors and disease characteristics of TED cases at EAMC coincide with local published journals, except for significant correlation with male sex and TRAb titers showing the variability of the disease and the need for further studies.","PeriodicalId":135031,"journal":{"name":"Journal of Ophthalmology & Clinical Research","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132521704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-14DOI: 10.24966/ocr-8887/100097
Dmitrenko Op, Karpova Ns, Abramova Oi, Nurbekov Mk, Arshinova Es
The C allele in the additive inheritance model and the TC heterozygous genotype in the codominant and recessive models serve as the genetic factor predisposing to this disease (p<0,001, OR: 2,121, 95% of CI: 1.435-3.133; p<0.001, OR: 2.499, 95% of CI: 1.595-3.915; p<0.001, OR: 2.507, 95% of CI: 1.612-3.900). In addition, the C allele was more common in women with AMD and in AMD patients over 65 years of age, which may be associated with a higher risk of AMD
{"title":"Association of Polymorphism rs12778366 of the SIRT1 Gene with the Risk of Age-Related Macular Degeneration","authors":"Dmitrenko Op, Karpova Ns, Abramova Oi, Nurbekov Mk, Arshinova Es","doi":"10.24966/ocr-8887/100097","DOIUrl":"https://doi.org/10.24966/ocr-8887/100097","url":null,"abstract":"The C allele in the additive inheritance model and the TC heterozygous genotype in the codominant and recessive models serve as the genetic factor predisposing to this disease (p<0,001, OR: 2,121, 95% of CI: 1.435-3.133; p<0.001, OR: 2.499, 95% of CI: 1.595-3.915; p<0.001, OR: 2.507, 95% of CI: 1.612-3.900). In addition, the C allele was more common in women with AMD and in AMD patients over 65 years of age, which may be associated with a higher risk of AMD","PeriodicalId":135031,"journal":{"name":"Journal of Ophthalmology & Clinical Research","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117269081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-14DOI: 10.24966/ocr-8887/100102
Aniana Katherine S Nicanor, M. R. Valencia
“White-Eyed Blow Out Fracture (WEBOF)" is a term used for children who had periorbital trauma with mild signs of soft tissue damage. WEBOF can be easily missed, resulting in a lost opportunity for surgical intervention. A pediatric patient presented with vomiting and diplopia after sustaining trauma, she was referred to our institution 2 weeks after a suspected head injury. Examination showed marked limitation on upgaze and downgaze on the right eye with accompanying diplopia
{"title":"White Eyed Blow Out Fracture - A Case Report","authors":"Aniana Katherine S Nicanor, M. R. Valencia","doi":"10.24966/ocr-8887/100102","DOIUrl":"https://doi.org/10.24966/ocr-8887/100102","url":null,"abstract":"“White-Eyed Blow Out Fracture (WEBOF)\" is a term used for children who had periorbital trauma with mild signs of soft tissue damage. WEBOF can be easily missed, resulting in a lost opportunity for surgical intervention. A pediatric patient presented with vomiting and diplopia after sustaining trauma, she was referred to our institution 2 weeks after a suspected head injury. Examination showed marked limitation on upgaze and downgaze on the right eye with accompanying diplopia","PeriodicalId":135031,"journal":{"name":"Journal of Ophthalmology & Clinical Research","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128733237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-14DOI: 10.24966/ocr-8887/100100
F. Co, Ajite Ko
The most determining feature of attendees for the intervention was their area of residence in relation to the venue of the surgery, other important features includes their gender, age, occupation and their visual acuities.
{"title":"Socio-Demographic Characteristics and Presenting Visual Acuity of Beneficiaries of a Free Cataract Surgical Intervention in Ekiti State, South-Western Nigeria","authors":"F. Co, Ajite Ko","doi":"10.24966/ocr-8887/100100","DOIUrl":"https://doi.org/10.24966/ocr-8887/100100","url":null,"abstract":"The most determining feature of attendees for the intervention was their area of residence in relation to the venue of the surgery, other important features includes their gender, age, occupation and their visual acuities.","PeriodicalId":135031,"journal":{"name":"Journal of Ophthalmology & Clinical Research","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124973065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-14DOI: 10.24966/ocr-8887/100101
Patricia Abigail Lim1, L. Ang
We report a case of a 21-year-old Filipino, with a history of progressive diplopia, who presented with headache, dizziness and vomiting. Ophthalmologic exam revealed light near dissociation, physiologic anisocoria, bilateral upgaze palsy, convergence retraction nystagmus and pseudo-abducens palsy of the left eye. Imaging was done, which revealed pineal neoplasm with obstructive hydrocephalus. This text aims to present a case of pineal gland neoplasm which presented as diplopia alongside signs and symptoms of Dorsal Midbrain Syndrome (Parinaud Syndrome).
{"title":"Pineal Gland Mass presenting as Parinaud Syndrome in a 21 Year Old Patient","authors":"Patricia Abigail Lim1, L. Ang","doi":"10.24966/ocr-8887/100101","DOIUrl":"https://doi.org/10.24966/ocr-8887/100101","url":null,"abstract":"We report a case of a 21-year-old Filipino, with a history of progressive diplopia, who presented with headache, dizziness and vomiting. Ophthalmologic exam revealed light near dissociation, physiologic anisocoria, bilateral upgaze palsy, convergence retraction nystagmus and pseudo-abducens palsy of the left eye. Imaging was done, which revealed pineal neoplasm with obstructive hydrocephalus. This text aims to present a case of pineal gland neoplasm which presented as diplopia alongside signs and symptoms of Dorsal Midbrain Syndrome (Parinaud Syndrome).","PeriodicalId":135031,"journal":{"name":"Journal of Ophthalmology & Clinical Research","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122883316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
For about 20 years, nanotechnological applications are intensively investigated in all fields of medicine. In ophthalmology, nanoparticles are of special interest as carrier systems for the targeted delivery of drugs, genes or siRNA to the anterior as well as to the posterior segment of the eye. Above that, sustained drug release plays a major role for the treatment of many ophthalmic diseases and nanoparticles have the potential to perform this task without inducing local adverse reactions. Nanoparticles are primarily defined by their size that has to range below 100 nm. All other characteristics are variable. The large variety of nanoparticle types and the fact, that they are easily modifiable allows their adaption to the task set for them. In this review, we summarize the application of nanoparticles in ophthalmology and describe the current challenges.
{"title":"Nanoparticles in Ophthalmology","authors":"Albert J. Augustin, Jenny Atorf","doi":"10.33140/jocr.06.03.01","DOIUrl":"https://doi.org/10.33140/jocr.06.03.01","url":null,"abstract":"For about 20 years, nanotechnological applications are intensively investigated in all fields of medicine. In ophthalmology, nanoparticles are of special interest as carrier systems for the targeted delivery of drugs, genes or siRNA to the anterior as well as to the posterior segment of the eye. Above that, sustained drug release plays a major role for the treatment of many ophthalmic diseases and nanoparticles have the potential to perform this task without inducing local adverse reactions. Nanoparticles are primarily defined by their size that has to range below 100 nm. All other characteristics are variable. The large variety of nanoparticle types and the fact, that they are easily modifiable allows their adaption to the task set for them. In this review, we summarize the application of nanoparticles in ophthalmology and describe the current challenges.","PeriodicalId":135031,"journal":{"name":"Journal of Ophthalmology & Clinical Research","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114963681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-04DOI: 10.24966/ocr-8887/100092
M. Nguyen, Courtney Crawford
Purtscher’s retinopathy is a rare microvasculopathy eye disease that causes sudden painless loss of vision after a severe injury but can be associated with nontraumatic etiologies. In this case, a 30-year-old female had noticeable decrease in visual acuity and a central scotoma to her right eye after undergoing ankle surgery
{"title":"Purtscher’s Retinopathy: A Case Report","authors":"M. Nguyen, Courtney Crawford","doi":"10.24966/ocr-8887/100092","DOIUrl":"https://doi.org/10.24966/ocr-8887/100092","url":null,"abstract":"Purtscher’s retinopathy is a rare microvasculopathy eye disease that causes sudden painless loss of vision after a severe injury but can be associated with nontraumatic etiologies. In this case, a 30-year-old female had noticeable decrease in visual acuity and a central scotoma to her right eye after undergoing ankle surgery","PeriodicalId":135031,"journal":{"name":"Journal of Ophthalmology & Clinical Research","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122189044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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