Pub Date : 2024-09-16DOI: 10.1186/s40249-024-01237-w
Felix K. Rubuga, Paula Moraga, Ayman Ahmed, Emmanuel Siddig, Eric Remera, Giovenale Moirano, Guéladio Cissé, Jürg Utzinger
Despite global efforts to reduce and eventually interrupt malaria transmission, the disease remains a pressing public health problem, especially in sub-Saharan Africa. This study presents a detailed spatio-temporal analysis of malaria transmission in Rwanda from 2012 to 2022. The main objective was to gain insights into the evolving patterns of malaria and to inform and tailor effective public health strategies. The study used yearly aggregated data of malaria cases from the Rwanda health management information system. We employed a multifaceted analytical approach, including descriptive statistics and spatio-temporal analysis across three demographic groups: children under the age of 5 years, and males and females above 5 years. Bayesian spatially explicit models and spatio scan statistics were utilised to examine geographic and temporal patterns of relative risks and to identify clusters of malaria transmission. We observed a significant increase in malaria cases from 2014 to 2018, peaking in 2016 for males and females aged above 5 years with counts of 98,645 and 116,627, respectively and in 2018 for under 5-year-old children with 84,440 cases with notable geographic disparities. Districts like Kamonyi (Southern Province), Ngoma, Kayonza and Bugesera (Eastern Province) exhibited high burdens, possibly influenced by factors such as climate, vector control practices, and cross-border dynamics. Bayesian spatially explicit modeling revealed elevated relative risks in numerous districts, underscoring the heterogeneity of malaria transmission in these districts, and thus contributing to an overall rising trend in malaria cases until 2018, followed by a subsequent decline. Our findings emphasize that the heterogeneity of malaria transmission is potentially driven by ecologic, socioeconomic, and behavioural factors. The study underscores the complexity of malaria transmission in Rwanda and calls for climate adaptive, gender-, age- and district-specific strategies in the national malaria control program. The emergence of both artemisinin and pyrethoids resistance and persistent high transmission in some districts necessitates continuous monitoring and innovative, data-driven approaches for effective and sustainable malaria control.
{"title":"Spatio-temporal dynamics of malaria in Rwanda between 2012 and 2022: a demography-specific analysis","authors":"Felix K. Rubuga, Paula Moraga, Ayman Ahmed, Emmanuel Siddig, Eric Remera, Giovenale Moirano, Guéladio Cissé, Jürg Utzinger","doi":"10.1186/s40249-024-01237-w","DOIUrl":"https://doi.org/10.1186/s40249-024-01237-w","url":null,"abstract":"Despite global efforts to reduce and eventually interrupt malaria transmission, the disease remains a pressing public health problem, especially in sub-Saharan Africa. This study presents a detailed spatio-temporal analysis of malaria transmission in Rwanda from 2012 to 2022. The main objective was to gain insights into the evolving patterns of malaria and to inform and tailor effective public health strategies. The study used yearly aggregated data of malaria cases from the Rwanda health management information system. We employed a multifaceted analytical approach, including descriptive statistics and spatio-temporal analysis across three demographic groups: children under the age of 5 years, and males and females above 5 years. Bayesian spatially explicit models and spatio scan statistics were utilised to examine geographic and temporal patterns of relative risks and to identify clusters of malaria transmission. We observed a significant increase in malaria cases from 2014 to 2018, peaking in 2016 for males and females aged above 5 years with counts of 98,645 and 116,627, respectively and in 2018 for under 5-year-old children with 84,440 cases with notable geographic disparities. Districts like Kamonyi (Southern Province), Ngoma, Kayonza and Bugesera (Eastern Province) exhibited high burdens, possibly influenced by factors such as climate, vector control practices, and cross-border dynamics. Bayesian spatially explicit modeling revealed elevated relative risks in numerous districts, underscoring the heterogeneity of malaria transmission in these districts, and thus contributing to an overall rising trend in malaria cases until 2018, followed by a subsequent decline. Our findings emphasize that the heterogeneity of malaria transmission is potentially driven by ecologic, socioeconomic, and behavioural factors. The study underscores the complexity of malaria transmission in Rwanda and calls for climate adaptive, gender-, age- and district-specific strategies in the national malaria control program. The emergence of both artemisinin and pyrethoids resistance and persistent high transmission in some districts necessitates continuous monitoring and innovative, data-driven approaches for effective and sustainable malaria control. ","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"20 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-13DOI: 10.1186/s40249-024-01231-2
Weiye Chen, Yiming Chen, Zile Cheng, Yiwen Chen, Chao Lv, Lingchao Ma, Nan Zhou, Jing Qian, Chang Liu, Min Li, Xiaokui Guo, Yongzhang Zhu
Certain infectious diseases are caused by specific bacterial pathogens, including syphilis, gonorrhea, typhoid and paratyphoid fever, diphtheria, pertussis, tetanus, leprosy, and tuberculosis. These diseases significantly impact global health, contributing heavily to the disease burden. The study aims to thoroughly evaluate the global burden of syphilis, gonorrhea, typhoid and paratyphoid fever, diphtheria, pertussis, tetanus, and leprosy. Leveraging the Global Burden of Disease (GBD) study 2021, age-specific and Socio-demographic Index (SDI)-specific incidence, disability-adjusted life-years (DALYs), and death for eight specific bacterial infections across 204 countries and territories from 1990 to 2021 were analyzed. Percentage changes in age-standardized incidence rate (ASIR), DALY rate, and mortality rate (ASMR) were also examined, with a focus on disease distribution across different regions, age groups, genders, and SDI. By 2021, among the eight diseases, gonococcal infection had the highest global ASIR [1096.58 per 100,000 population, 95% uncertainty interval (UI): 838.70, 1385.47 per 100,000 population], and syphilis had the highest global age-standardized DALY rate (107.13 per 100,000 population, 95% UI: 41.77, 212.12 per 100,000 population). Except for syphilis and gonococcal infection, the age-standardized DALY rate of the remaining diseases decreased by at least 55% compared to 1990, with tetanus showing the largest decrease by at least 90%. Globally, significant declines in the ASIR, age-standardized DALY rate, and ASMR for these eight bacterial infections have been observed in association with increases in the SDI. Regions with lower SDI, such as sub-Saharan Africa, experienced a relatively higher burden of these eight bacterial infections. Although there has been an overall decline in these eight diseases, they continue to pose significant public health challenges, particularly in low SDI regions. To further reduce this burden in these areas, targeted intervention strategies are essential, including multi-sectoral collaboration, policy support, improved WASH management, and enhanced research efforts.
{"title":"Global patterns of syphilis, gonococcal infection, typhoid fever, paratyphoid fever, diphtheria, pertussis, tetanus, and leprosy from 1990 to 2021: findings from the Global Burden of Disease Study 2021","authors":"Weiye Chen, Yiming Chen, Zile Cheng, Yiwen Chen, Chao Lv, Lingchao Ma, Nan Zhou, Jing Qian, Chang Liu, Min Li, Xiaokui Guo, Yongzhang Zhu","doi":"10.1186/s40249-024-01231-2","DOIUrl":"https://doi.org/10.1186/s40249-024-01231-2","url":null,"abstract":"Certain infectious diseases are caused by specific bacterial pathogens, including syphilis, gonorrhea, typhoid and paratyphoid fever, diphtheria, pertussis, tetanus, leprosy, and tuberculosis. These diseases significantly impact global health, contributing heavily to the disease burden. The study aims to thoroughly evaluate the global burden of syphilis, gonorrhea, typhoid and paratyphoid fever, diphtheria, pertussis, tetanus, and leprosy. Leveraging the Global Burden of Disease (GBD) study 2021, age-specific and Socio-demographic Index (SDI)-specific incidence, disability-adjusted life-years (DALYs), and death for eight specific bacterial infections across 204 countries and territories from 1990 to 2021 were analyzed. Percentage changes in age-standardized incidence rate (ASIR), DALY rate, and mortality rate (ASMR) were also examined, with a focus on disease distribution across different regions, age groups, genders, and SDI. By 2021, among the eight diseases, gonococcal infection had the highest global ASIR [1096.58 per 100,000 population, 95% uncertainty interval (UI): 838.70, 1385.47 per 100,000 population], and syphilis had the highest global age-standardized DALY rate (107.13 per 100,000 population, 95% UI: 41.77, 212.12 per 100,000 population). Except for syphilis and gonococcal infection, the age-standardized DALY rate of the remaining diseases decreased by at least 55% compared to 1990, with tetanus showing the largest decrease by at least 90%. Globally, significant declines in the ASIR, age-standardized DALY rate, and ASMR for these eight bacterial infections have been observed in association with increases in the SDI. Regions with lower SDI, such as sub-Saharan Africa, experienced a relatively higher burden of these eight bacterial infections. Although there has been an overall decline in these eight diseases, they continue to pose significant public health challenges, particularly in low SDI regions. To further reduce this burden in these areas, targeted intervention strategies are essential, including multi-sectoral collaboration, policy support, improved WASH management, and enhanced research efforts. ","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"42 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-10DOI: 10.1186/s40249-024-01232-1
Philippe Douchet, Bart Haegeman, Jean-François Allienne, Jérôme Boissier, Bruno Senghor, Olivier Rey
Combating infectious diseases and halting biodiversity loss are intertwined challenges crucial to ensure global health. Biodiversity can constrain the spread of vector-borne pathogens circulation, necessitating a deeper understanding of ecological mechanisms underlying this pattern. Our study evaluates the relative importance of biodiversity and the abundance of Bulinus truncatus, a major intermediate host for the trematode Schistosoma haematobium on the circulation of this human pathogen at aquatic transmission sites. We combined mathematical modelling and a molecular based empirical study to specifically assess the effect of co-infections between S. haematobium and other trematodes within their B. truncatus snail hosts; and B. truncatus abundance at transmission sites, on the production of S. haematobium infective cercariae stages released into the aquatic environment. Our modelling approach shows that more competitive trematode species exploiting B. truncatus as an intermediate host at the transmission site level leads to higher co-infection rates within snail hosts, subsequently reducing the production of S. haematobium cercariae. Conversely, an increase in B. truncatus abundance results in lower co-infection rates, and a higher proportion of S. haematobium cercariae released into the environment. Our empirical data from the field support these findings, indicating a significant negative effect of local trematode species richness (P-value = 0.029; AIC = 14.9) and co-infection rates (P-value = 0.02, AIC = 17.4) on the dominance of S. haematobium based on our GLMM models, while B. truncatus abundance positively influences S. haematobium dominance (P-value = 0.047, AIC = 20.1). Our study highlights the importance of biodiversity in influencing the transmission of S. haematobium through the effect of antagonistic interactions between trematodes within bulinid snail hosts. This effect intensifies when B. truncatus populations are low, promoting co-infections within snails. In line with the One Health concept, our results suggest that maintaining high level of freshwater biodiversity to sustain global trematode diversity at transmission sites can help reducing the circulation of Schistosoma species locally.
{"title":"The abundance of snail hosts mediates the effects of antagonist interactions between trematodes on the transmission of human schistosomes","authors":"Philippe Douchet, Bart Haegeman, Jean-François Allienne, Jérôme Boissier, Bruno Senghor, Olivier Rey","doi":"10.1186/s40249-024-01232-1","DOIUrl":"https://doi.org/10.1186/s40249-024-01232-1","url":null,"abstract":"Combating infectious diseases and halting biodiversity loss are intertwined challenges crucial to ensure global health. Biodiversity can constrain the spread of vector-borne pathogens circulation, necessitating a deeper understanding of ecological mechanisms underlying this pattern. Our study evaluates the relative importance of biodiversity and the abundance of Bulinus truncatus, a major intermediate host for the trematode Schistosoma haematobium on the circulation of this human pathogen at aquatic transmission sites. We combined mathematical modelling and a molecular based empirical study to specifically assess the effect of co-infections between S. haematobium and other trematodes within their B. truncatus snail hosts; and B. truncatus abundance at transmission sites, on the production of S. haematobium infective cercariae stages released into the aquatic environment. Our modelling approach shows that more competitive trematode species exploiting B. truncatus as an intermediate host at the transmission site level leads to higher co-infection rates within snail hosts, subsequently reducing the production of S. haematobium cercariae. Conversely, an increase in B. truncatus abundance results in lower co-infection rates, and a higher proportion of S. haematobium cercariae released into the environment. Our empirical data from the field support these findings, indicating a significant negative effect of local trematode species richness (P-value = 0.029; AIC = 14.9) and co-infection rates (P-value = 0.02, AIC = 17.4) on the dominance of S. haematobium based on our GLMM models, while B. truncatus abundance positively influences S. haematobium dominance (P-value = 0.047, AIC = 20.1). Our study highlights the importance of biodiversity in influencing the transmission of S. haematobium through the effect of antagonistic interactions between trematodes within bulinid snail hosts. This effect intensifies when B. truncatus populations are low, promoting co-infections within snails. In line with the One Health concept, our results suggest that maintaining high level of freshwater biodiversity to sustain global trematode diversity at transmission sites can help reducing the circulation of Schistosoma species locally. ","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"11 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Since the COVID-19 pandemic began, a plethora of modeling studies related to COVID-19 have been released. While some models stand out due to their innovative approaches, others are flawed in their methodology. To assist novices, frontline healthcare workers, and public health policymakers in navigating the complex landscape of these models, we introduced a structured framework named MODELS. This framework is designed to detail the essential steps and considerations for creating a dependable epidemic model, offering direction to researchers engaged in epidemic modeling endeavors.
{"title":"MODELS: a six-step framework for developing an infectious disease model","authors":"Jia Rui, Kangguo Li, Hongjie Wei, Xiaohao Guo, Zeyu Zhao, Yao Wang, Wentao Song, Buasiyamu Abudunaibi, Tianmu Chen","doi":"10.1186/s40249-024-01195-3","DOIUrl":"https://doi.org/10.1186/s40249-024-01195-3","url":null,"abstract":"Since the COVID-19 pandemic began, a plethora of modeling studies related to COVID-19 have been released. While some models stand out due to their innovative approaches, others are flawed in their methodology. To assist novices, frontline healthcare workers, and public health policymakers in navigating the complex landscape of these models, we introduced a structured framework named MODELS. This framework is designed to detail the essential steps and considerations for creating a dependable epidemic model, offering direction to researchers engaged in epidemic modeling endeavors. ","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"127 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140612996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Culex pipiens pallens and Culex pipiens quinquefasciatus are the dominant species of Culex mosquitoes in China and important disease vectors. Long-term use of insecticides can cause mutations in the voltage-gated sodium channel (vgsc) gene of mosquitoes, but little is known about the current status and evolutionary origins of vgsc gene in different geographic populations. Therefore, this study aimed to determine the current status of vgsc genes in Cx. p. pallens and Cx. p. quinquefasciatus in China and to investigate the evolutionary inheritance of neighboring downstream introns of the vgsc gene to determine the impact of insecticides on long-term evolution. Sampling was conducted from July to September 2021 in representative habitats of 22 provincial-level administrative divisions in China. Genomic DNA was extracted from 1308 mosquitoes, the IIS6 fragment of the vgsc gene on the nerve cell membrane was amplified using polymerase chain reaction, and the sequence was used to evaluate allele frequency and knockdown resistance (kdr) frequency. MEGA 11 was used to construct neighbor-joining (NJ) tree. PopART was used to build a TCS network. There were 6 alleles and 6 genotypes at the L1014 locus, which included the wild-type alleles TTA/L and CTA/L and the mutant alleles TTT/F, TTC/F, TCT/S and TCA/S. The geographic populations with a kdr frequency less than 20.00% were mainly concentrated in the regions north of 38° N, and the geographic populations with a kdr frequency greater than 80.00% were concentrated in the regions south of 30° N. kdr frequency increased with decreasing latitude. And within the same latitude, the frequency of kdr in large cities is relatively high. Mutations were correlated with the number of introns. The mutant allele TCA/S has only one intron, the mutant allele TTT/F has three introns, and the wild-type allele TTA/L has 17 introns. Cx. p. pallens and Cx. p. quinquefasciatus have developed resistance to insecticides in most regions of China. The neighboring downstream introns of the vgsc gene gradually decreased to one intron with the mutation of the vgsc gene. Mutations may originate from multiple mutation events rather than from a single origin, and populations lacking mutations may be genetically isolated.
库蚊（Culex pipiens pallens）和库蚊（Culex pipiens quinquefasciatus）是中国库蚊的主要种类，也是重要的病媒。长期使用杀虫剂会导致蚊子的电压门控钠通道（vgsc）基因突变，但人们对不同地理种群中vgsc基因的现状和进化起源知之甚少。因此，本研究旨在确定中国Cx. p. pallens和Cx. p. quinquefasciatus中vgsc基因的现状，并调查vgsc基因邻近下游内含子的进化遗传，以确定杀虫剂对长期进化的影响。研究于2021年7月至9月在中国22个省级行政区的代表性栖息地采样。从1308只蚊子中提取基因组DNA，利用聚合酶链式反应扩增神经细胞膜上vgsc基因的IIS6片段，并利用序列评估等位基因频率和抗性基因敲除频率（kdr）。使用 MEGA 11 构建邻接树（NJ）。PopART 用于构建 TCS 网络。L1014 基因座上有 6 个等位基因和 6 个基因型，包括野生型等位基因 TTA/L 和 CTA/L，以及突变型等位基因 TTT/F、TTC/F、TCT/S 和 TCA/S。kdr频率小于20.00%的地理种群主要集中在北纬38°以北地区，kdr频率大于80.00%的地理种群主要集中在北纬30°以南地区。而在同一纬度上，大城市的 kdr 频率相对较高。突变与内含子的数量有关。突变等位基因 TCA/S 只有一个内含子，突变等位基因 TTT/F 有三个内含子，野生型等位基因 TTA/L 有 17 个内含子。Cx. p. pallens和Cx. p. quinquefasciatus在中国大部分地区对杀虫剂产生了抗药性。随着 vgsc 基因的突变，相邻的下游内含子逐渐减少为一个内含子。突变可能来自多个突变事件，而不是单一来源，缺乏突变的种群可能在遗传上是孤立的。
{"title":"Mutations and intron polymorphisms in voltage-gated sodium channel genes of different geographic populations of Culex pipiens pallens/Culex pipiens quinquefasciatus in China","authors":"Wenyu Li, Delong Ma, Qunzheng Mu, Xinxin Zhou, Dongdong Hua, Chunchun Zhao, Qiyong Liu, Jun Wang, Fengxia Meng","doi":"10.1186/s40249-024-01197-1","DOIUrl":"https://doi.org/10.1186/s40249-024-01197-1","url":null,"abstract":"Culex pipiens pallens and Culex pipiens quinquefasciatus are the dominant species of Culex mosquitoes in China and important disease vectors. Long-term use of insecticides can cause mutations in the voltage-gated sodium channel (vgsc) gene of mosquitoes, but little is known about the current status and evolutionary origins of vgsc gene in different geographic populations. Therefore, this study aimed to determine the current status of vgsc genes in Cx. p. pallens and Cx. p. quinquefasciatus in China and to investigate the evolutionary inheritance of neighboring downstream introns of the vgsc gene to determine the impact of insecticides on long-term evolution. Sampling was conducted from July to September 2021 in representative habitats of 22 provincial-level administrative divisions in China. Genomic DNA was extracted from 1308 mosquitoes, the IIS6 fragment of the vgsc gene on the nerve cell membrane was amplified using polymerase chain reaction, and the sequence was used to evaluate allele frequency and knockdown resistance (kdr) frequency. MEGA 11 was used to construct neighbor-joining (NJ) tree. PopART was used to build a TCS network. There were 6 alleles and 6 genotypes at the L1014 locus, which included the wild-type alleles TTA/L and CTA/L and the mutant alleles TTT/F, TTC/F, TCT/S and TCA/S. The geographic populations with a kdr frequency less than 20.00% were mainly concentrated in the regions north of 38° N, and the geographic populations with a kdr frequency greater than 80.00% were concentrated in the regions south of 30° N. kdr frequency increased with decreasing latitude. And within the same latitude, the frequency of kdr in large cities is relatively high. Mutations were correlated with the number of introns. The mutant allele TCA/S has only one intron, the mutant allele TTT/F has three introns, and the wild-type allele TTA/L has 17 introns. Cx. p. pallens and Cx. p. quinquefasciatus have developed resistance to insecticides in most regions of China. The neighboring downstream introns of the vgsc gene gradually decreased to one intron with the mutation of the vgsc gene. Mutations may originate from multiple mutation events rather than from a single origin, and populations lacking mutations may be genetically isolated. ","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"72 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140600249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12DOI: 10.1186/s40249-024-01198-0
Xiao-Xi Zhang, Zohar Lederman, Le-Fei Han, Janna M. Schurer, Li-Hua Xiao, Zhi-Bing Zhang, Qiu-Lan Chen, Dirk Pfeiffer, Michael P. Ward, Banchob Sripa, Sarah Gabriël, Kuldeep Dhama, Krishna Prasad Acharya, Lucy J. Robertson, Sharon L. Deem, Cécile Aenishaenslin, Filipe Dantas-Torres, Domenico Otranto, Delia Grace, Yang Wang, Peng Li, Chao Fu, Patrícia Poeta, Md. Tanvir Rahman, Kokouvi Kassegne, Yong-Zhang Zhu, Kun Yin, Jiming Liu, Zhao-Jun Wang, Xiao-Kui Guo, Wen-Feng Gong, Bernhard Schwartländer, Ming-Hui Ren, Xiao-Nong Zhou
Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Commission (OHAC) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest impact. This viewpoint describes the agenda of, and motivation for, the recently formed OHAC. Recognizing the urgent need for evidence to support the formulation of necessary action plans, OHAC advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health implementation. By promoting broader engagement and connection of multidisciplinary stakeholders, OHAC envisions a collaborative global platform for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health.
{"title":"Towards an actionable One Health approach","authors":"Xiao-Xi Zhang, Zohar Lederman, Le-Fei Han, Janna M. Schurer, Li-Hua Xiao, Zhi-Bing Zhang, Qiu-Lan Chen, Dirk Pfeiffer, Michael P. Ward, Banchob Sripa, Sarah Gabriël, Kuldeep Dhama, Krishna Prasad Acharya, Lucy J. Robertson, Sharon L. Deem, Cécile Aenishaenslin, Filipe Dantas-Torres, Domenico Otranto, Delia Grace, Yang Wang, Peng Li, Chao Fu, Patrícia Poeta, Md. Tanvir Rahman, Kokouvi Kassegne, Yong-Zhang Zhu, Kun Yin, Jiming Liu, Zhao-Jun Wang, Xiao-Kui Guo, Wen-Feng Gong, Bernhard Schwartländer, Ming-Hui Ren, Xiao-Nong Zhou","doi":"10.1186/s40249-024-01198-0","DOIUrl":"https://doi.org/10.1186/s40249-024-01198-0","url":null,"abstract":"Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Commission (OHAC) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest impact. This viewpoint describes the agenda of, and motivation for, the recently formed OHAC. Recognizing the urgent need for evidence to support the formulation of necessary action plans, OHAC advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health implementation. By promoting broader engagement and connection of multidisciplinary stakeholders, OHAC envisions a collaborative global platform for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health. ","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"63 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140599984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-14DOI: 10.1186/s40249-024-01193-5
Judicaël Obame-Nkoghe, Adjoavi Esse Agossou, Gerald Mboowa, Basile Kamgang, Cyril Caminade, Dawn C. Duke, Andrew Karanja Githeko, Obed M. Ogega, Nestor Engone Elloué, Fatou Bintou Sarr, Dieudonné Nkoghe, Pierre Kengne, Nicaise T. Ndam, Christophe Paupy, Moses Bockarie, Patricks Voua Otomo
We look at the link between climate change and vector-borne diseases in low- and middle-income countries in Africa. The large endemicity and escalating threat of diseases such as malaria and arboviral diseases, intensified by climate change, disproportionately affects vulnerable communities globally. We highlight the urgency of prioritizing research and development, advocating for robust scientific inquiry to promote adaptation strategies, and the vital role that the next generation of African research leaders will play in addressing these challenges. Despite significant challenges such as funding shortages within countries, various pan-African-oriented funding bodies such as the African Academy of Sciences, the Africa Research Excellence Fund, the Wellcome Trust, the U.S. National Institutes of Health, and the Bill and Melinda Gates Foundation as well as initiatives such as the African Research Initiative for Scientific Excellence and the Pan-African Mosquito Control Association, have empowered (or are empowering) these researchers by supporting capacity building activities, including continental and global networking, skill development, mentoring, and African-led research. This article underscores the urgency of increased national investment in research, proposing the establishment of research government agencies to drive evidence-based interventions. Collaboration between governments and scientific communities, sustained by pan-African funding bodies, is crucial. Through these efforts, African nations are likely to enhance the resilience and adaptive capacity of their systems and communities by navigating these challenges effectively, fostering scientific excellence and implementing transformative solutions against climate-sensitive vector-borne diseases.
{"title":"Climate-influenced vector-borne diseases in Africa: a call to empower the next generation of African researchers for sustainable solutions","authors":"Judicaël Obame-Nkoghe, Adjoavi Esse Agossou, Gerald Mboowa, Basile Kamgang, Cyril Caminade, Dawn C. Duke, Andrew Karanja Githeko, Obed M. Ogega, Nestor Engone Elloué, Fatou Bintou Sarr, Dieudonné Nkoghe, Pierre Kengne, Nicaise T. Ndam, Christophe Paupy, Moses Bockarie, Patricks Voua Otomo","doi":"10.1186/s40249-024-01193-5","DOIUrl":"https://doi.org/10.1186/s40249-024-01193-5","url":null,"abstract":"We look at the link between climate change and vector-borne diseases in low- and middle-income countries in Africa. The large endemicity and escalating threat of diseases such as malaria and arboviral diseases, intensified by climate change, disproportionately affects vulnerable communities globally. We highlight the urgency of prioritizing research and development, advocating for robust scientific inquiry to promote adaptation strategies, and the vital role that the next generation of African research leaders will play in addressing these challenges. Despite significant challenges such as funding shortages within countries, various pan-African-oriented funding bodies such as the African Academy of Sciences, the Africa Research Excellence Fund, the Wellcome Trust, the U.S. National Institutes of Health, and the Bill and Melinda Gates Foundation as well as initiatives such as the African Research Initiative for Scientific Excellence and the Pan-African Mosquito Control Association, have empowered (or are empowering) these researchers by supporting capacity building activities, including continental and global networking, skill development, mentoring, and African-led research. This article underscores the urgency of increased national investment in research, proposing the establishment of research government agencies to drive evidence-based interventions. Collaboration between governments and scientific communities, sustained by pan-African funding bodies, is crucial. Through these efforts, African nations are likely to enhance the resilience and adaptive capacity of their systems and communities by navigating these challenges effectively, fostering scientific excellence and implementing transformative solutions against climate-sensitive vector-borne diseases.","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"2018 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140125064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-05DOI: 10.1186/s40249-024-01178-4
Xuejiao Ma, Shenning Lu, Wei Ding, Shanying Deng, Duoquan Wang, Ning Xiao, Yeromin Mlacha, Lewis Husain, Xiaonong Zhou
<p>Tripartite partnership, compared with the bilateral model, is envisioned as an opportunity to foster stronger and more trusting partnerships [1]. However, China has historically been characterized as principally reliant on bilateral engagement in global health [2]. The China-Tanzania Cooperation Project on Malaria Control was conducted by National Institute of Parasitic Diseases at China CDC and Chinese Center for Tropical Diseases Research, Ifakara Health Institute in Tanzania and funding agencies from 2015 to 2022, with an aim to explore the applicability of Chinese experience on malaria control to reduce malaria disease burden in the local context of Tanzania. In the tripartite project funded by the former UK Department for International Development (DFID) and later the Bill & Melinda Gates Foundation (BMGF), China’s partners were expected to share the extensively parallel practices achieved from the control and elimination of malaria for over 70 years, UK’s partners were to deliver resources and design global health strategies, while Tanzanian local staff collaborated with triangular partners to ensure the project implementation [3]. In the project, the trilateral cooperation has transparent management mechanism to ensure the concrete management and implementation of the project [4] (Additional file 1: Figure S1). This Brief is to provide recommendations for China’s engagement in global health by distilling the experience from the innovative tripartite partnership of the project.</p><p>Impressive achievements were made through the pioneering efforts of triangular stakeholders of the project: (1) 1,7-malaria Reactive Community-based Testing and Response (1,7-mRCTR) was successfully derived from local context sharing Chinese 1-3-7 norm through the field implementation; (2) malaria prevalence in the intervention wards declined by 81% from 2015 to 2018 and further declined by 55% from 2018 to 2022 [3]; (3) a local team composed of 37 Tanzanian community health workers were built to be paired with Chinese on-site technical staff to ensure the project implementation and sustainability[3]; (4) the project’s effectiveness and achievements contributed to the scaling up of 1,7-mRCTR in three other African countries including Burkina Faso, Senegal, and Zambia for sustainable development [4].</p><p>The project also encountered some challenges in this trilateral partnership, (1) China’s immature systems for global health engagement with scarce resources allocated to this innovative partnership [5], e.g. the complicated procedures of funding transfer from China to Tanzania, the time-consuming visa application for Chinese staff’s field support, and the scarce resources. Therefore, it is essential to mobilize resources for the trilateral collaboration with developing a solid system for China’s participation in global health. In order to effectively mobilize resources for these trilateral collaborations, it is imperative to develop a robust logistics s
UK:United KingdomDFID:Department for International DevelopmentBMGF:Bill & Melinda Gates FoundationCDC:Center for Disease Control1,7-mRCTR:1,7-Malaria Reactive Community-based Testing and ResponseHuang A, Cao C, Xiao AY, Karemere H, Christian ME, Nicolas KK, Xue M, Tang K.三边南南合作为转变卫生发展援助带来的机遇和挑战：来自刚果民主共和国-联合国儿童基金会-中国孕产妇、新生儿和儿童健康项目的证据。Glob Health.2023. https://doi.org/10.1186/s12992-023-00934-9.Article Google Scholar Liu P, Guo Y, Qian X, Tang S, Li Z, Chen L. China's distinctive engagement in global health.柳叶刀。2014;384(9945):793–804.文章发表于 PubMed PubMed Central Google Scholar Chang W, Cohen J, Wang DQ, Abdulla S, Mahende MK, Gavana T, Scott V, Msuya HM, Mwanyika-Sando M, Njau RJA, Lu SN, Temu S. Masanja H, Anthony W., Msuya HM, Mwanyika-Sando M, Njau RJA, Lu SN, Temu S., Msuya HM、Masanja H、Anthony W、Aregawi WM、Sunder N、Kun T、Bruxvoort K、Kitau J、Kihwele F、Chila G、Michael M、Castro M、Menzies NA、Kim S、Ning X、Zhou XN、Chaki P、Mlacha YP.1,7-疟疾反应性社区检测和反应（1,7-mRCTR）方法对坦桑尼亚疟疾流行的影响。Infect Dis Poverty.2023; 12(1):116.Article PubMed PubMed Central Google Scholar Wang X, Liu P, Xu T, et al. China-UK partnership for global health: Practices and implications of the Global Health support Programme 2012-2019.Glob Health Res Policy.2020; 5:13.Article PubMed PubMed Central Google Scholar Husain L, Bloom G, McPherson S. The China-UK Global Health Support Programme: Looking for new roles and partnerships in changing times.Glob Health Res Policy.2020;5:26.文章PubMed PubMed Central Google Scholar 下载参考文献我们感谢所有参与中国-坦桑尼亚疟疾控制合作项目的人员。本研究得到了中国-英国-坦桑尼亚疟疾控制试点项目（项目编号：GHSP-CS-OP4-D02）、BMGF支持的中国-坦桑尼亚疟疾控制示范项目（项目编号：INV-009832）、中非疟疾控制合作项目（项目编号：2020-C4-0002-3）的支持。作者和单位中国疾病预防控制中心寄生虫病所（中国热带病研究中心）、国家卫生计生委寄生虫与媒介生物学重点实验室、世界卫生组织热带病合作中心、国家热带病国际研究中心，上海，马雪娇，陆申宁，丁伟，王多全，肖宁&；周晓农 中国香港，香港大学 邓山英 中国上海，上海交通大学医学院全球健康学院、中国热带病研究中心 王多全、肖宁、周晓农 中国上海，上海交通大学医学院全球健康学院、中国热带病研究中心Xiaonong Zhou Ifakara Health Institute, Dar-es-Salaam, Tanzania Yeromin MlachaInstitute of Development Studies, Brighton、作者：Lewis Husain作者：Xuejiao Ma查看作者发表的文章您也可以在PubMed Google Scholar中搜索该作者Shenning Lu查看作者发表的文章您也可以在PubMed Google Scholar中搜索该作者Wei Ding查看作者发表的文章您也可以在PubMed Google Scholar中搜索该作者Shaning Deng查看作者发表的文章您也可以在PubMed Google Scholar中搜索该作者Duoquan Wang查看作者发表的文章您也可以在PubMed Google Scholar中搜索该作者发表作品您也可以在PubMed Google Scholar中搜索该作者肖宁查看作者发表作品您也可以在PubMed Google Scholar中搜索该作者Yeromin Mlacha查看作者发表作品您也可以在PubMed Google Scholar中搜索该作者Lewis Husain查看作者发表作品您也可以在PubMed Google Scholar中搜索该作者周晓农查看作者发表作品您也可以在PubMed Google Scholar中搜索该作者ContributionsXNZ和NX构思了这篇文章。DQW设计了框架并修改了论文。XJM和SNL撰写了手稿初稿。LH和YM提供了参考文献和建议。WD和SYD修改了论文。伦理批准和参与同意书不适用。发表同意书不适用。利益冲突周晓农是《贫困传染病》杂志的主编。他没有参与稿件的同行评审或处理。作者没有其他需要披露的利益冲突：图 S1.中国-坦桑尼亚疟疾控制合作项目三方伙伴关系。CN 中国; UK 英国; BMGF 比尔盖茨基金会; TZ 坦桑尼亚; 1,7-mRCTR 1,7-malaria Reactive Community-based Testing and Response.开放存取 本文采用知识共享署名 4.0（Creative Commons Attribution 4.0）模式许可。 创作共用 "许可协议允许以任何媒介或格式使用、共享、改编、分发和复制文章，但必须注明原作者和出处，提供指向 "创作共用 "许可协议的链接，并说明是否进行了修改。本文中的图片或其他第三方材料均包含在文章的知识共享许可协议中，除非在材料的署名栏中另有说明。如果材料未包含在文章的知识共享许可协议中，且您打算使用的材料不符合法律规定或超出许可
{"title":"Development of innovative tripartite partnership for China’s engagement in global health: recommendations from China-Tanzania Cooperation Project on Malaria Control","authors":"Xuejiao Ma, Shenning Lu, Wei Ding, Shanying Deng, Duoquan Wang, Ning Xiao, Yeromin Mlacha, Lewis Husain, Xiaonong Zhou","doi":"10.1186/s40249-024-01178-4","DOIUrl":"https://doi.org/10.1186/s40249-024-01178-4","url":null,"abstract":"<p>Tripartite partnership, compared with the bilateral model, is envisioned as an opportunity to foster stronger and more trusting partnerships [1]. However, China has historically been characterized as principally reliant on bilateral engagement in global health [2]. The China-Tanzania Cooperation Project on Malaria Control was conducted by National Institute of Parasitic Diseases at China CDC and Chinese Center for Tropical Diseases Research, Ifakara Health Institute in Tanzania and funding agencies from 2015 to 2022, with an aim to explore the applicability of Chinese experience on malaria control to reduce malaria disease burden in the local context of Tanzania. In the tripartite project funded by the former UK Department for International Development (DFID) and later the Bill & Melinda Gates Foundation (BMGF), China’s partners were expected to share the extensively parallel practices achieved from the control and elimination of malaria for over 70 years, UK’s partners were to deliver resources and design global health strategies, while Tanzanian local staff collaborated with triangular partners to ensure the project implementation [3]. In the project, the trilateral cooperation has transparent management mechanism to ensure the concrete management and implementation of the project [4] (Additional file 1: Figure S1). This Brief is to provide recommendations for China’s engagement in global health by distilling the experience from the innovative tripartite partnership of the project.</p><p>Impressive achievements were made through the pioneering efforts of triangular stakeholders of the project: (1) 1,7-malaria Reactive Community-based Testing and Response (1,7-mRCTR) was successfully derived from local context sharing Chinese 1-3-7 norm through the field implementation; (2) malaria prevalence in the intervention wards declined by 81% from 2015 to 2018 and further declined by 55% from 2018 to 2022 [3]; (3) a local team composed of 37 Tanzanian community health workers were built to be paired with Chinese on-site technical staff to ensure the project implementation and sustainability[3]; (4) the project’s effectiveness and achievements contributed to the scaling up of 1,7-mRCTR in three other African countries including Burkina Faso, Senegal, and Zambia for sustainable development [4].</p><p>The project also encountered some challenges in this trilateral partnership, (1) China’s immature systems for global health engagement with scarce resources allocated to this innovative partnership [5], e.g. the complicated procedures of funding transfer from China to Tanzania, the time-consuming visa application for Chinese staff’s field support, and the scarce resources. Therefore, it is essential to mobilize resources for the trilateral collaboration with developing a solid system for China’s participation in global health. In order to effectively mobilize resources for these trilateral collaborations, it is imperative to develop a robust logistics s","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"29 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140033618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-27DOI: 10.1186/s40249-024-01188-2
Changqiang Zhou, Tao Li, Jian Du, Dapeng Yin, Xiujun Li, Shixue Li
The disease burden of tuberculosis (TB) was heavy in Hainan Province, China, and the information on transmission patterns was limited with few studies. This atudy aims to further explore the epidemiological characteristics and influencing factors of TB in Hainan Province, and thereby contribute valuable scientific evidences for TB elimination in Hainan Province. The TB notification data in Hainan Province from 2013 to 2022 were collected from the Chinese National Disease Control Information System Tuberculosis Surveillance System, along with socio-economic data. The spatial–temporal and population distributions were analyzed, and spatial autocorrelation analysis was conducted to explore TB notification rate clustering. In addition, the epidemiological characteristics of the cases among in-country migrants were described, and the delay pattern in seeking medical care was investigated. Finally, a geographically and temporally weighted regression (GTWR) model was adopted to analyze the relationship between TB notification rate and socio-economic indicators. The tailored control suggestions in different regions for TB elimination was provided by understanding epidemiological characteristics and risk factors obtained by GTWR. From 2013 to 2022, 64,042 cases of TB were notified in Hainan Province. The estimated annual percentage change of TB notification rate in Hainan Province from 2013 to 2020 was − 6.88% [95% confidence interval (CI): − 5.30%, − 3.69%], with higher rates in central and southern regions. The majority of patients were males (76.33%) and farmers (67.80%). Cases among in-country migrants primarily originated from Sichuan (369 cases), Heilongjiang (267 cases), Hunan (236 cases), Guangdong (174 cases), and Guangxi (139 cases), accounting for 53%. The majority (98.83%) of TB cases were notified through passive case finding approaches, with delay in seeking care. The GTWR analysis showed that gross domestic product per capita, the number of medical institutions and health personnel per 10,000 people were main factors affecting the high TB notification rates in some regions in Hainan Province. Different regional tailored measures such as more TB specialized hospitals were proposed based on the characteristics of each region. The notification rate of TB in Hainan Province has been declining overall but still remained high in central and southern regions. Particular attention should be paid to the prevalence of TB among males, farmers, and out-of-province migrant populations. The notification rate was also influenced by economic development and medical conditions, indicating the need of more TB specialized hospitals, active surveillance and other tailored prevention and control measures to promote the progress of TB elimination in Hainan Province.
{"title":"Toward tuberculosis elimination by understanding epidemiologic characteristics and risk factors in Hainan Province, China","authors":"Changqiang Zhou, Tao Li, Jian Du, Dapeng Yin, Xiujun Li, Shixue Li","doi":"10.1186/s40249-024-01188-2","DOIUrl":"https://doi.org/10.1186/s40249-024-01188-2","url":null,"abstract":"The disease burden of tuberculosis (TB) was heavy in Hainan Province, China, and the information on transmission patterns was limited with few studies. This atudy aims to further explore the epidemiological characteristics and influencing factors of TB in Hainan Province, and thereby contribute valuable scientific evidences for TB elimination in Hainan Province. The TB notification data in Hainan Province from 2013 to 2022 were collected from the Chinese National Disease Control Information System Tuberculosis Surveillance System, along with socio-economic data. The spatial–temporal and population distributions were analyzed, and spatial autocorrelation analysis was conducted to explore TB notification rate clustering. In addition, the epidemiological characteristics of the cases among in-country migrants were described, and the delay pattern in seeking medical care was investigated. Finally, a geographically and temporally weighted regression (GTWR) model was adopted to analyze the relationship between TB notification rate and socio-economic indicators. The tailored control suggestions in different regions for TB elimination was provided by understanding epidemiological characteristics and risk factors obtained by GTWR. From 2013 to 2022, 64,042 cases of TB were notified in Hainan Province. The estimated annual percentage change of TB notification rate in Hainan Province from 2013 to 2020 was − 6.88% [95% confidence interval (CI): − 5.30%, − 3.69%], with higher rates in central and southern regions. The majority of patients were males (76.33%) and farmers (67.80%). Cases among in-country migrants primarily originated from Sichuan (369 cases), Heilongjiang (267 cases), Hunan (236 cases), Guangdong (174 cases), and Guangxi (139 cases), accounting for 53%. The majority (98.83%) of TB cases were notified through passive case finding approaches, with delay in seeking care. The GTWR analysis showed that gross domestic product per capita, the number of medical institutions and health personnel per 10,000 people were main factors affecting the high TB notification rates in some regions in Hainan Province. Different regional tailored measures such as more TB specialized hospitals were proposed based on the characteristics of each region. The notification rate of TB in Hainan Province has been declining overall but still remained high in central and southern regions. Particular attention should be paid to the prevalence of TB among males, farmers, and out-of-province migrant populations. The notification rate was also influenced by economic development and medical conditions, indicating the need of more TB specialized hospitals, active surveillance and other tailored prevention and control measures to promote the progress of TB elimination in Hainan Province.","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"74 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139980812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-27DOI: 10.1186/s40249-024-01187-3
Qin Liu, Lei Duan, Yun-Hai Guo, Li-Min Yang, Yi Zhang, Shi-Zhu Li, Shan Lv, Wei Hu, Nan-Sheng Chen, Xiao-Nong Zhou
Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China, the Philippines and Indonesia. Oncomelania hupensis (Gastropoda: Pomatiopsidae) is the unique intermediate host of S. japonicum. A complete genome sequence of O. hupensis will enable the fundamental understanding of snail biology as well as its co-evolution with the S. japonicum parasite. Assembling a high-quality reference genome of O. hupehensis will provide data for further research on the snail biology and controlling the spread of S. japonicum. The draft genome was de novo assembly using the long-read sequencing technology (PacBio Sequel II) and corrected with Illumina sequencing data. Then, using Hi-C sequencing data, the genome was assembled at the chromosomal level. CAFE was used to do analysis of contraction and expansion of the gene family and CodeML module in PAML was used for positive selection analysis in protein coding sequences. A total length of 1.46 Gb high-quality O. hupensis genome with 17 unique full-length chromosomes (2n = 34) of the individual including a contig N50 of 1.35 Mb and a scaffold N50 of 75.08 Mb. Additionally, 95.03% of these contig sequences were anchored in 17 chromosomes. After scanning the assembled genome, a total of 30,604 protein-coding genes were predicted. Among them, 86.67% were functionally annotated. Further phylogenetic analysis revealed that O. hupensis was separated from a common ancestor of Pomacea canaliculata and Bellamya purificata approximately 170 million years ago. Comparing the genome of O. hupensis with its most recent common ancestor, it showed 266 significantly expanded and 58 significantly contracted gene families (P < 0.05). Functional enrichment of the expanded gene families indicated that they were mainly involved with intracellular, DNA-mediated transposition, DNA integration and transposase activity. Integrated use of multiple sequencing technologies, we have successfully constructed the genome at the chromosomal-level of O. hupensis. These data will not only provide the compressive genomic information, but also benefit future work on population genetics of this snail as well as evolutional studies between S. japonicum and the snail host.
{"title":"Chromosome-level genome assembly of Oncomelania hupensis: the intermediate snail host of Schistosoma japonicum","authors":"Qin Liu, Lei Duan, Yun-Hai Guo, Li-Min Yang, Yi Zhang, Shi-Zhu Li, Shan Lv, Wei Hu, Nan-Sheng Chen, Xiao-Nong Zhou","doi":"10.1186/s40249-024-01187-3","DOIUrl":"https://doi.org/10.1186/s40249-024-01187-3","url":null,"abstract":"Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China, the Philippines and Indonesia. Oncomelania hupensis (Gastropoda: Pomatiopsidae) is the unique intermediate host of S. japonicum. A complete genome sequence of O. hupensis will enable the fundamental understanding of snail biology as well as its co-evolution with the S. japonicum parasite. Assembling a high-quality reference genome of O. hupehensis will provide data for further research on the snail biology and controlling the spread of S. japonicum. The draft genome was de novo assembly using the long-read sequencing technology (PacBio Sequel II) and corrected with Illumina sequencing data. Then, using Hi-C sequencing data, the genome was assembled at the chromosomal level. CAFE was used to do analysis of contraction and expansion of the gene family and CodeML module in PAML was used for positive selection analysis in protein coding sequences. A total length of 1.46 Gb high-quality O. hupensis genome with 17 unique full-length chromosomes (2n = 34) of the individual including a contig N50 of 1.35 Mb and a scaffold N50 of 75.08 Mb. Additionally, 95.03% of these contig sequences were anchored in 17 chromosomes. After scanning the assembled genome, a total of 30,604 protein-coding genes were predicted. Among them, 86.67% were functionally annotated. Further phylogenetic analysis revealed that O. hupensis was separated from a common ancestor of Pomacea canaliculata and Bellamya purificata approximately 170 million years ago. Comparing the genome of O. hupensis with its most recent common ancestor, it showed 266 significantly expanded and 58 significantly contracted gene families (P < 0.05). Functional enrichment of the expanded gene families indicated that they were mainly involved with intracellular, DNA-mediated transposition, DNA integration and transposase activity. Integrated use of multiple sequencing technologies, we have successfully constructed the genome at the chromosomal-level of O. hupensis. These data will not only provide the compressive genomic information, but also benefit future work on population genetics of this snail as well as evolutional studies between S. japonicum and the snail host. ","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":"29 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139980551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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