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Spatio-temporal dynamics of malaria in Rwanda between 2012 and 2022: a demography-specific analysis 2012 年至 2022 年卢旺达疟疾的时空动态:特定人口分析
IF 8.1 1区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2024-09-16 DOI: 10.1186/s40249-024-01237-w
Felix K. Rubuga, Paula Moraga, Ayman Ahmed, Emmanuel Siddig, Eric Remera, Giovenale Moirano, Guéladio Cissé, Jürg Utzinger
Despite global efforts to reduce and eventually interrupt malaria transmission, the disease remains a pressing public health problem, especially in sub-Saharan Africa. This study presents a detailed spatio-temporal analysis of malaria transmission in Rwanda from 2012 to 2022. The main objective was to gain insights into the evolving patterns of malaria and to inform and tailor effective public health strategies. The study used yearly aggregated data of malaria cases from the Rwanda health management information system. We employed a multifaceted analytical approach, including descriptive statistics and spatio-temporal analysis across three demographic groups: children under the age of 5 years, and males and females above 5 years. Bayesian spatially explicit models and spatio scan statistics were utilised to examine geographic and temporal patterns of relative risks and to identify clusters of malaria transmission. We observed a significant increase in malaria cases from 2014 to 2018, peaking in 2016 for males and females aged above 5 years with counts of 98,645 and 116,627, respectively and in 2018 for under 5-year-old children with 84,440 cases with notable geographic disparities. Districts like Kamonyi (Southern Province), Ngoma, Kayonza and Bugesera (Eastern Province) exhibited high burdens, possibly influenced by factors such as climate, vector control practices, and cross-border dynamics. Bayesian spatially explicit modeling revealed elevated relative risks in numerous districts, underscoring the heterogeneity of malaria transmission in these districts, and thus contributing to an overall rising trend in malaria cases until 2018, followed by a subsequent decline. Our findings emphasize that the heterogeneity of malaria transmission is potentially driven by ecologic, socioeconomic, and behavioural factors. The study underscores the complexity of malaria transmission in Rwanda and calls for climate adaptive, gender-, age- and district-specific strategies in the national malaria control program. The emergence of both artemisinin and pyrethoids resistance and persistent high transmission in some districts necessitates continuous monitoring and innovative, data-driven approaches for effective and sustainable malaria control.
尽管全球都在努力减少并最终阻断疟疾的传播,但该疾病仍然是一个紧迫的公共卫生问题,尤其是在撒哈拉以南非洲地区。本研究对卢旺达 2012 年至 2022 年的疟疾传播情况进行了详细的时空分析。主要目的是深入了解疟疾不断演变的模式,为制定有效的公共卫生战略提供依据。研究使用了卢旺达卫生管理信息系统中的疟疾病例年度汇总数据。我们采用了多方面的分析方法,包括描述性统计和三个人口群体的时空分析:5 岁以下儿童、5 岁以上男性和女性。我们利用贝叶斯空间明确模型和空间扫描统计来研究相对风险的地理和时间模式,并确定疟疾传播集群。我们观察到,从 2014 年到 2018 年,疟疾病例大幅增加,2016 年达到高峰,5 岁以上男性和女性病例数分别为 98,645 例和 116,627 例,2018 年 5 岁以下儿童病例数为 84,440 例,地域差异明显。卡莫尼(南部省)、恩戈马、卡永扎和布吉塞拉(东部省)等地区的病例数较高,可能受到气候、病媒控制措施和跨境动态等因素的影响。贝叶斯空间显式建模显示,许多地区的相对风险升高,凸显了这些地区疟疾传播的异质性,从而导致疟疾病例在 2018 年前总体呈上升趋势,随后有所下降。我们的研究结果强调,疟疾传播的异质性可能是由生态、社会经济和行为因素驱动的。这项研究强调了卢旺达疟疾传播的复杂性,并呼吁在国家疟疾控制计划中采取适应气候、针对不同性别、年龄和地区的策略。青蒿素和拟除虫菊酯抗药性的出现以及一些地区持续的高传播率要求我们必须持续监测并采用创新的数据驱动型方法,以实现有效、可持续的疟疾控制。
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引用次数: 0
Global patterns of syphilis, gonococcal infection, typhoid fever, paratyphoid fever, diphtheria, pertussis, tetanus, and leprosy from 1990 to 2021: findings from the Global Burden of Disease Study 2021 1990 至 2021 年梅毒、淋球菌感染、伤寒、副伤寒、白喉、百日咳、破伤风和麻风病的全球模式:2021 年全球疾病负担研究的结果
IF 8.1 1区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2024-09-13 DOI: 10.1186/s40249-024-01231-2
Weiye Chen, Yiming Chen, Zile Cheng, Yiwen Chen, Chao Lv, Lingchao Ma, Nan Zhou, Jing Qian, Chang Liu, Min Li, Xiaokui Guo, Yongzhang Zhu
Certain infectious diseases are caused by specific bacterial pathogens, including syphilis, gonorrhea, typhoid and paratyphoid fever, diphtheria, pertussis, tetanus, leprosy, and tuberculosis. These diseases significantly impact global health, contributing heavily to the disease burden. The study aims to thoroughly evaluate the global burden of syphilis, gonorrhea, typhoid and paratyphoid fever, diphtheria, pertussis, tetanus, and leprosy. Leveraging the Global Burden of Disease (GBD) study 2021, age-specific and Socio-demographic Index (SDI)-specific incidence, disability-adjusted life-years (DALYs), and death for eight specific bacterial infections across 204 countries and territories from 1990 to 2021 were analyzed. Percentage changes in age-standardized incidence rate (ASIR), DALY rate, and mortality rate (ASMR) were also examined, with a focus on disease distribution across different regions, age groups, genders, and SDI. By 2021, among the eight diseases, gonococcal infection had the highest global ASIR [1096.58 per 100,000 population, 95% uncertainty interval (UI): 838.70, 1385.47 per 100,000 population], and syphilis had the highest global age-standardized DALY rate (107.13 per 100,000 population, 95% UI: 41.77, 212.12 per 100,000 population). Except for syphilis and gonococcal infection, the age-standardized DALY rate of the remaining diseases decreased by at least 55% compared to 1990, with tetanus showing the largest decrease by at least 90%. Globally, significant declines in the ASIR, age-standardized DALY rate, and ASMR for these eight bacterial infections have been observed in association with increases in the SDI. Regions with lower SDI, such as sub-Saharan Africa, experienced a relatively higher burden of these eight bacterial infections. Although there has been an overall decline in these eight diseases, they continue to pose significant public health challenges, particularly in low SDI regions. To further reduce this burden in these areas, targeted intervention strategies are essential, including multi-sectoral collaboration, policy support, improved WASH management, and enhanced research efforts.
某些传染病是由特定细菌病原体引起的,包括梅毒、淋病、伤寒和副伤寒、白喉、百日咳、破伤风、麻风病和结核病。这些疾病严重影响全球健康,给疾病造成沉重负担。这项研究旨在全面评估梅毒、淋病、伤寒和副伤寒、白喉、百日咳、破伤风和麻风病的全球负担。利用 2021 年全球疾病负担(GBD)研究,分析了 1990 年至 2021 年期间 204 个国家和地区中八种特定细菌感染的年龄特异性和社会人口指数(SDI)特异性发病率、残疾调整生命年(DALYs)和死亡率。此外,还研究了年龄标准化发病率(ASIR)、残疾调整生命年(DALY)和死亡率(ASMR)的百分比变化,重点关注不同地区、年龄组、性别和 SDI 的疾病分布情况。到 2021 年,在这八种疾病中,淋球菌感染的全球 ASIR 最高[每 10 万人 1096.58 例,95% 不确定区间:每 10 万人 838.70 例,1385.47 例],梅毒的全球年龄标准化 DALY 率最高(每 10 万人 107.13 例,95% 不确定区间:每 10 万人 41.77 例,212.12 例)。与 1990 年相比,除梅毒和淋球菌感染外,其余疾病的年龄标准化残疾调整寿命年率至少下降了 55%,其中破伤风下降幅度最大,至少下降了 90%。在全球范围内,随着 SDI 的增加,这八种细菌感染的 ASIR、年龄标准化残疾调整寿命年率和 ASMR 都出现了显著下降。撒哈拉以南非洲等 SDI 较低的地区,这八种细菌感染的负担相对较高。虽然这八种疾病的发病率总体上有所下降,但它们仍对公共卫生构成重大挑战,特别是在 SDI 较低的地区。为了进一步减轻这些地区的负担,必须采取有针对性的干预战略,包括多部门合作、政策支持、改善讲卫生运动的管理和加强研究工作。
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引用次数: 0
The abundance of snail hosts mediates the effects of antagonist interactions between trematodes on the transmission of human schistosomes 蜗牛宿主的丰富性介导了吸虫之间的拮抗相互作用对人类血吸虫传播的影响
IF 8.1 1区 医学 Q1 INFECTIOUS DISEASES Pub Date : 2024-09-10 DOI: 10.1186/s40249-024-01232-1
Philippe Douchet, Bart Haegeman, Jean-François Allienne, Jérôme Boissier, Bruno Senghor, Olivier Rey
Combating infectious diseases and halting biodiversity loss are intertwined challenges crucial to ensure global health. Biodiversity can constrain the spread of vector-borne pathogens circulation, necessitating a deeper understanding of ecological mechanisms underlying this pattern. Our study evaluates the relative importance of biodiversity and the abundance of Bulinus truncatus, a major intermediate host for the trematode Schistosoma haematobium on the circulation of this human pathogen at aquatic transmission sites. We combined mathematical modelling and a molecular based empirical study to specifically assess the effect of co-infections between S. haematobium and other trematodes within their B. truncatus snail hosts; and B. truncatus abundance at transmission sites, on the production of S. haematobium infective cercariae stages released into the aquatic environment. Our modelling approach shows that more competitive trematode species exploiting B. truncatus as an intermediate host at the transmission site level leads to higher co-infection rates within snail hosts, subsequently reducing the production of S. haematobium cercariae. Conversely, an increase in B. truncatus abundance results in lower co-infection rates, and a higher proportion of S. haematobium cercariae released into the environment. Our empirical data from the field support these findings, indicating a significant negative effect of local trematode species richness (P-value = 0.029; AIC = 14.9) and co-infection rates (P-value = 0.02, AIC = 17.4) on the dominance of S. haematobium based on our GLMM models, while B. truncatus abundance positively influences S. haematobium dominance (P-value = 0.047, AIC = 20.1). Our study highlights the importance of biodiversity in influencing the transmission of S. haematobium through the effect of antagonistic interactions between trematodes within bulinid snail hosts. This effect intensifies when B. truncatus populations are low, promoting co-infections within snails. In line with the One Health concept, our results suggest that maintaining high level of freshwater biodiversity to sustain global trematode diversity at transmission sites can help reducing the circulation of Schistosoma species locally.
防治传染病和遏制生物多样性丧失是相互交织的挑战,对确保全球健康至关重要。生物多样性可以限制病媒传播的病原体循环传播,因此有必要深入了解这种模式背后的生态机制。我们的研究评估了生物多样性和Bulinus truncatus(血吸虫的主要中间宿主)的丰度对这种人类病原体在水生传播地点的循环的相对重要性。我们结合数学建模和基于分子的实证研究,具体评估了血吸虫和其他吸虫在其Bulinus truncatus螺宿主体内的共同感染,以及Bulinus truncatus在传播地点的丰度对释放到水生环境中的血吸虫感染性carcariae阶段的产生的影响。我们的建模方法表明,在传播地点,更多具有竞争力的吸虫物种利用B. truncatus作为中间宿主,会导致蜗牛宿主体内的共感染率升高,从而减少血吸虫蚴的产生。相反,B. truncatus 数量的增加会导致共感染率降低,释放到环境中的 S. haematobium 蚴的比例增加。我们的实地经验数据支持这些发现,根据我们的 GLMM 模型,当地吸虫物种丰富度(P 值 = 0.029;AIC = 14.9)和共感染率(P 值 = 0.02,AIC = 17.4)对血吸虫的优势地位有显著的负面影响,而 B. truncatus 的丰度对血吸虫的优势地位有正面影响(P 值 = 0.047,AIC = 20.1)。我们的研究强调了生物多样性在影响血吸虫传播方面的重要性,它是通过吸虫在球螺宿主体内的拮抗作用产生的。当B. truncatus种群数量较少时,这种影响会加剧,从而促进蜗牛内的共同感染。与 "同一健康 "理念一致,我们的研究结果表明,在传播地点保持高水平的淡水生物多样性以维持全球吸虫多样性,有助于减少血吸虫在当地的传播。
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引用次数: 0
MODELS: a six-step framework for developing an infectious disease model 模式:制定传染病模式的六步框架
IF 8.1 1区 医学 Q1 Medicine Pub Date : 2024-04-17 DOI: 10.1186/s40249-024-01195-3
Jia Rui, Kangguo Li, Hongjie Wei, Xiaohao Guo, Zeyu Zhao, Yao Wang, Wentao Song, Buasiyamu Abudunaibi, Tianmu Chen
Since the COVID-19 pandemic began, a plethora of modeling studies related to COVID-19 have been released. While some models stand out due to their innovative approaches, others are flawed in their methodology. To assist novices, frontline healthcare workers, and public health policymakers in navigating the complex landscape of these models, we introduced a structured framework named MODELS. This framework is designed to detail the essential steps and considerations for creating a dependable epidemic model, offering direction to researchers engaged in epidemic modeling endeavors.
自 COVID-19 大流行开始以来,发布了大量与 COVID-19 相关的模型研究。一些模型因其创新方法而脱颖而出,而另一些模型则在方法论上存在缺陷。为了帮助新手、一线医疗工作者和公共卫生政策制定者了解这些模型的复杂情况,我们推出了一个名为 MODELS 的结构化框架。该框架旨在详细说明创建可靠流行病模型的基本步骤和注意事项,为从事流行病建模工作的研究人员指明方向。
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引用次数: 0
Mutations and intron polymorphisms in voltage-gated sodium channel genes of different geographic populations of Culex pipiens pallens/Culex pipiens quinquefasciatus in China 中国不同地理种群库蚊电压门控钠通道基因的突变和内含子多态性
IF 8.1 1区 医学 Q1 Medicine Pub Date : 2024-04-15 DOI: 10.1186/s40249-024-01197-1
Wenyu Li, Delong Ma, Qunzheng Mu, Xinxin Zhou, Dongdong Hua, Chunchun Zhao, Qiyong Liu, Jun Wang, Fengxia Meng
Culex pipiens pallens and Culex pipiens quinquefasciatus are the dominant species of Culex mosquitoes in China and important disease vectors. Long-term use of insecticides can cause mutations in the voltage-gated sodium channel (vgsc) gene of mosquitoes, but little is known about the current status and evolutionary origins of vgsc gene in different geographic populations. Therefore, this study aimed to determine the current status of vgsc genes in Cx. p. pallens and Cx. p. quinquefasciatus in China and to investigate the evolutionary inheritance of neighboring downstream introns of the vgsc gene to determine the impact of insecticides on long-term evolution. Sampling was conducted from July to September 2021 in representative habitats of 22 provincial-level administrative divisions in China. Genomic DNA was extracted from 1308 mosquitoes, the IIS6 fragment of the vgsc gene on the nerve cell membrane was amplified using polymerase chain reaction, and the sequence was used to evaluate allele frequency and knockdown resistance (kdr) frequency. MEGA 11 was used to construct neighbor-joining (NJ) tree. PopART was used to build a TCS network. There were 6 alleles and 6 genotypes at the L1014 locus, which included the wild-type alleles TTA/L and CTA/L and the mutant alleles TTT/F, TTC/F, TCT/S and TCA/S. The geographic populations with a kdr frequency less than 20.00% were mainly concentrated in the regions north of 38° N, and the geographic populations with a kdr frequency greater than 80.00% were concentrated in the regions south of 30° N. kdr frequency increased with decreasing latitude. And within the same latitude, the frequency of kdr in large cities is relatively high. Mutations were correlated with the number of introns. The mutant allele TCA/S has only one intron, the mutant allele TTT/F has three introns, and the wild-type allele TTA/L has 17 introns. Cx. p. pallens and Cx. p. quinquefasciatus have developed resistance to insecticides in most regions of China. The neighboring downstream introns of the vgsc gene gradually decreased to one intron with the mutation of the vgsc gene. Mutations may originate from multiple mutation events rather than from a single origin, and populations lacking mutations may be genetically isolated.
库蚊(Culex pipiens pallens)和库蚊(Culex pipiens quinquefasciatus)是中国库蚊的主要种类,也是重要的病媒。长期使用杀虫剂会导致蚊子的电压门控钠通道(vgsc)基因突变,但人们对不同地理种群中vgsc基因的现状和进化起源知之甚少。因此,本研究旨在确定中国Cx. p. pallens和Cx. p. quinquefasciatus中vgsc基因的现状,并调查vgsc基因邻近下游内含子的进化遗传,以确定杀虫剂对长期进化的影响。研究于2021年7月至9月在中国22个省级行政区的代表性栖息地采样。从1308只蚊子中提取基因组DNA,利用聚合酶链式反应扩增神经细胞膜上vgsc基因的IIS6片段,并利用序列评估等位基因频率和抗性基因敲除频率(kdr)。使用 MEGA 11 构建邻接树(NJ)。PopART 用于构建 TCS 网络。L1014 基因座上有 6 个等位基因和 6 个基因型,包括野生型等位基因 TTA/L 和 CTA/L,以及突变型等位基因 TTT/F、TTC/F、TCT/S 和 TCA/S。kdr频率小于20.00%的地理种群主要集中在北纬38°以北地区,kdr频率大于80.00%的地理种群主要集中在北纬30°以南地区。而在同一纬度上,大城市的 kdr 频率相对较高。突变与内含子的数量有关。突变等位基因 TCA/S 只有一个内含子,突变等位基因 TTT/F 有三个内含子,野生型等位基因 TTA/L 有 17 个内含子。Cx. p. pallens和Cx. p. quinquefasciatus在中国大部分地区对杀虫剂产生了抗药性。随着 vgsc 基因的突变,相邻的下游内含子逐渐减少为一个内含子。突变可能来自多个突变事件,而不是单一来源,缺乏突变的种群可能在遗传上是孤立的。
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引用次数: 0
Towards an actionable One Health approach 实现可操作的 "一个健康 "方法
IF 8.1 1区 医学 Q1 Medicine Pub Date : 2024-04-12 DOI: 10.1186/s40249-024-01198-0
Xiao-Xi Zhang, Zohar Lederman, Le-Fei Han, Janna M. Schurer, Li-Hua Xiao, Zhi-Bing Zhang, Qiu-Lan Chen, Dirk Pfeiffer, Michael P. Ward, Banchob Sripa, Sarah Gabriël, Kuldeep Dhama, Krishna Prasad Acharya, Lucy J. Robertson, Sharon L. Deem, Cécile Aenishaenslin, Filipe Dantas-Torres, Domenico Otranto, Delia Grace, Yang Wang, Peng Li, Chao Fu, Patrícia Poeta, Md. Tanvir Rahman, Kokouvi Kassegne, Yong-Zhang Zhu, Kun Yin, Jiming Liu, Zhao-Jun Wang, Xiao-Kui Guo, Wen-Feng Gong, Bernhard Schwartländer, Ming-Hui Ren, Xiao-Nong Zhou
Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Commission (OHAC) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest impact. This viewpoint describes the agenda of, and motivation for, the recently formed OHAC. Recognizing the urgent need for evidence to support the formulation of necessary action plans, OHAC advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health implementation. By promoting broader engagement and connection of multidisciplinary stakeholders, OHAC envisions a collaborative global platform for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health.
尽管全球层面越来越重视加强 "一个健康 "能力建设,但在制定和实施实际干预措施方面仍然存在挑战,尤其是在亚太地区。认识到这些差距,"同一健康行动委员会"(OHAC)作为 "同一健康行动 "的学术团体应运而生。本观点介绍了最近成立的 "一个健康行动委员会 "的议程和动机。认识到迫切需要证据来支持制定必要的行动计划,OHAC 主张采用自下而上和自上而下的方法来确定当前在防治人畜共患病、抗生素耐药性、解决食品安全方面的差距,并加强能力建设,以实施对具体情况有敏感认识的 "一个健康 "行动。通过促进多学科利益相关者更广泛的参与和联系,OHAC 设想建立一个全球合作平台,在 "一体健康 "强有力的道德原则指导下,创造创新的 "一体健康 "知识、提炼实践经验和提出可行的政策建议。
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引用次数: 0
Climate-influenced vector-borne diseases in Africa: a call to empower the next generation of African researchers for sustainable solutions 非洲受气候影响的病媒传染疾病:呼吁增强下一代非洲研究人员的能力,以找到可持续的解决方案
IF 8.1 1区 医学 Q1 Medicine Pub Date : 2024-03-14 DOI: 10.1186/s40249-024-01193-5
Judicaël Obame-Nkoghe, Adjoavi Esse Agossou, Gerald Mboowa, Basile Kamgang, Cyril Caminade, Dawn C. Duke, Andrew Karanja Githeko, Obed M. Ogega, Nestor Engone Elloué, Fatou Bintou Sarr, Dieudonné Nkoghe, Pierre Kengne, Nicaise T. Ndam, Christophe Paupy, Moses Bockarie, Patricks Voua Otomo
We look at the link between climate change and vector-borne diseases in low- and middle-income countries in Africa. The large endemicity and escalating threat of diseases such as malaria and arboviral diseases, intensified by climate change, disproportionately affects vulnerable communities globally. We highlight the urgency of prioritizing research and development, advocating for robust scientific inquiry to promote adaptation strategies, and the vital role that the next generation of African research leaders will play in addressing these challenges. Despite significant challenges such as funding shortages within countries, various pan-African-oriented funding bodies such as the African Academy of Sciences, the Africa Research Excellence Fund, the Wellcome Trust, the U.S. National Institutes of Health, and the Bill and Melinda Gates Foundation as well as initiatives such as the African Research Initiative for Scientific Excellence and the Pan-African Mosquito Control Association, have empowered (or are empowering) these researchers by supporting capacity building activities, including continental and global networking, skill development, mentoring, and African-led research. This article underscores the urgency of increased national investment in research, proposing the establishment of research government agencies to drive evidence-based interventions. Collaboration between governments and scientific communities, sustained by pan-African funding bodies, is crucial. Through these efforts, African nations are likely to enhance the resilience and adaptive capacity of their systems and communities by navigating these challenges effectively, fostering scientific excellence and implementing transformative solutions against climate-sensitive vector-borne diseases.
我们关注气候变化与非洲中低收入国家病媒传播疾病之间的联系。气候变化加剧了疟疾和虫媒病毒疾病等疾病的大规模流行和不断升级的威胁,对全球弱势社区造成了极大的影响。我们强调,当务之急是优先开展研究和开发工作,倡导开展强有力的科学调查以促进适应战略,以及下一代非洲科研领袖在应对这些挑战方面将发挥的重要作用。尽管面临国内资金短缺等重大挑战,但非洲科学院、非洲卓越研究基金、惠康信托基金、美国国立卫生研究院、比尔及梅林达-盖茨基金会等各种面向泛非的资助机构,以及非洲科学卓越研究倡议和泛非蚊虫控制协会等倡议,已经(或正在)通过支持能力建设活动,包括非洲大陆和全球网络、技能发展、指导和非洲主导的研究,增强这些研究人员的能力。这篇文章强调了增加国家研究投资的紧迫性,建议建立研究型政府机构,以推动循证干预措施。在泛非资助机构的支持下,政府与科学界之间的合作至关重要。通过这些努力,非洲国家有可能有效地应对这些挑战,促进科学卓越性,并实施针对气候敏感病媒传染疾病的变革性解决方案,从而提高其系统和社区的复原力和适应能力。
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引用次数: 0
Development of innovative tripartite partnership for China’s engagement in global health: recommendations from China-Tanzania Cooperation Project on Malaria Control 发展创新型三方伙伴关系,促进中国参与全球卫生事业:中国-坦桑尼亚疟疾控制合作项目的建议
IF 8.1 1区 医学 Q1 Medicine Pub Date : 2024-03-05 DOI: 10.1186/s40249-024-01178-4
Xuejiao Ma, Shenning Lu, Wei Ding, Shanying Deng, Duoquan Wang, Ning Xiao, Yeromin Mlacha, Lewis Husain, Xiaonong Zhou

Tripartite partnership, compared with the bilateral model, is envisioned as an opportunity to foster stronger and more trusting partnerships [1]. However, China has historically been characterized as principally reliant on bilateral engagement in global health [2]. The China-Tanzania Cooperation Project on Malaria Control was conducted by National Institute of Parasitic Diseases at China CDC and Chinese Center for Tropical Diseases Research, Ifakara Health Institute in Tanzania and funding agencies from 2015 to 2022, with an aim to explore the applicability of Chinese experience on malaria control to reduce malaria disease burden in the local context of Tanzania. In the tripartite project funded by the former UK Department for International Development (DFID) and later the Bill & Melinda Gates Foundation (BMGF), China’s partners were expected to share the extensively parallel practices achieved from the control and elimination of malaria for over 70 years, UK’s partners were to deliver resources and design global health strategies, while Tanzanian local staff collaborated with triangular partners to ensure the project implementation [3]. In the project, the trilateral cooperation has transparent management mechanism to ensure the concrete management and implementation of the project [4] (Additional file 1: Figure S1). This Brief is to provide recommendations for China’s engagement in global health by distilling the experience from the innovative tripartite partnership of the project.

Impressive achievements were made through the pioneering efforts of triangular stakeholders of the project: (1) 1,7-malaria Reactive Community-based Testing and Response (1,7-mRCTR) was successfully derived from local context sharing Chinese 1-3-7 norm through the field implementation; (2) malaria prevalence in the intervention wards declined by 81% from 2015 to 2018 and further declined by 55% from 2018 to 2022 [3]; (3) a local team composed of 37 Tanzanian community health workers were built to be paired with Chinese on-site technical staff to ensure the project implementation and sustainability[3]; (4) the project’s effectiveness and achievements contributed to the scaling up of 1,7-mRCTR in three other African countries including Burkina Faso, Senegal, and Zambia for sustainable development [4].

The project also encountered some challenges in this trilateral partnership, (1) China’s immature systems for global health engagement with scarce resources allocated to this innovative partnership [5], e.g. the complicated procedures of funding transfer from China to Tanzania, the time-consuming visa application for Chinese staff’s field support, and the scarce resources. Therefore, it is essential to mobilize resources for the trilateral collaboration with developing a solid system for China’s participation in global health. In order to effectively mobilize resources for these trilateral collaborations, it is imperative to develop a robust logistics s

UK:United KingdomDFID:Department for International DevelopmentBMGF:Bill & Melinda Gates FoundationCDC:Center for Disease Control1,7-mRCTR:1,7-Malaria Reactive Community-based Testing and ResponseHuang A, Cao C, Xiao AY, Karemere H, Christian ME, Nicolas KK, Xue M, Tang K.三边南南合作为转变卫生发展援助带来的机遇和挑战:来自刚果民主共和国-联合国儿童基金会-中国孕产妇、新生儿和儿童健康项目的证据。Glob Health.2023. https://doi.org/10.1186/s12992-023-00934-9.Article Google Scholar Liu P, Guo Y, Qian X, Tang S, Li Z, Chen L. China's distinctive engagement in global health.柳叶刀。2014;384(9945):793–804.文章发表于 PubMed PubMed Central Google Scholar Chang W, Cohen J, Wang DQ, Abdulla S, Mahende MK, Gavana T, Scott V, Msuya HM, Mwanyika-Sando M, Njau RJA, Lu SN, Temu S. Masanja H, Anthony W., Msuya HM, Mwanyika-Sando M, Njau RJA, Lu SN, Temu S., Msuya HM、Masanja H、Anthony W、Aregawi WM、Sunder N、Kun T、Bruxvoort K、Kitau J、Kihwele F、Chila G、Michael M、Castro M、Menzies NA、Kim S、Ning X、Zhou XN、Chaki P、Mlacha YP.1,7-疟疾反应性社区检测和反应(1,7-mRCTR)方法对坦桑尼亚疟疾流行的影响。Infect Dis Poverty.2023; 12(1):116.Article PubMed PubMed Central Google Scholar Wang X, Liu P, Xu T, et al. China-UK partnership for global health: Practices and implications of the Global Health support Programme 2012-2019.Glob Health Res Policy.2020; 5:13.Article PubMed PubMed Central Google Scholar Husain L, Bloom G, McPherson S. The China-UK Global Health Support Programme: Looking for new roles and partnerships in changing times.Glob Health Res Policy.2020;5:26.文章PubMed PubMed Central Google Scholar 下载参考文献我们感谢所有参与中国-坦桑尼亚疟疾控制合作项目的人员。本研究得到了中国-英国-坦桑尼亚疟疾控制试点项目(项目编号:GHSP-CS-OP4-D02)、BMGF支持的中国-坦桑尼亚疟疾控制示范项目(项目编号:INV-009832)、中非疟疾控制合作项目(项目编号:2020-C4-0002-3)的支持。作者和单位中国疾病预防控制中心寄生虫病所(中国热带病研究中心)、国家卫生计生委寄生虫与媒介生物学重点实验室、世界卫生组织热带病合作中心、国家热带病国际研究中心,上海,马雪娇,陆申宁,丁伟,王多全,肖宁&周晓农 中国香港,香港大学 邓山英 中国上海,上海交通大学医学院全球健康学院、中国热带病研究中心 王多全、肖宁、周晓农 中国上海,上海交通大学医学院全球健康学院、中国热带病研究中心Xiaonong Zhou Ifakara Health Institute, Dar-es-Salaam, Tanzania Yeromin MlachaInstitute of Development Studies, Brighton、作者:Lewis Husain作者:Xuejiao Ma查看作者发表的文章您也可以在PubMed Google Scholar中搜索该作者Shenning Lu查看作者发表的文章您也可以在PubMed Google Scholar中搜索该作者Wei Ding查看作者发表的文章您也可以在PubMed Google Scholar中搜索该作者Shaning Deng查看作者发表的文章您也可以在PubMed Google Scholar中搜索该作者Duoquan Wang查看作者发表的文章您也可以在PubMed Google Scholar中搜索该作者发表作品您也可以在PubMed Google Scholar中搜索该作者肖宁查看作者发表作品您也可以在PubMed Google Scholar中搜索该作者Yeromin Mlacha查看作者发表作品您也可以在PubMed Google Scholar中搜索该作者Lewis Husain查看作者发表作品您也可以在PubMed Google Scholar中搜索该作者周晓农查看作者发表作品您也可以在PubMed Google Scholar中搜索该作者ContributionsXNZ和NX构思了这篇文章。DQW设计了框架并修改了论文。XJM和SNL撰写了手稿初稿。LH和YM提供了参考文献和建议。WD和SYD修改了论文。伦理批准和参与同意书不适用。发表同意书不适用。利益冲突周晓农是《贫困传染病》杂志的主编。他没有参与稿件的同行评审或处理。作者没有其他需要披露的利益冲突:图 S1.中国-坦桑尼亚疟疾控制合作项目三方伙伴关系。CN 中国; UK 英国; BMGF 比尔盖茨基金会; TZ 坦桑尼亚; 1,7-mRCTR 1,7-malaria Reactive Community-based Testing and Response.开放存取 本文采用知识共享署名 4.0(Creative Commons Attribution 4.0)模式许可。 创作共用 "许可协议允许以任何媒介或格式使用、共享、改编、分发和复制文章,但必须注明原作者和出处,提供指向 "创作共用 "许可协议的链接,并说明是否进行了修改。本文中的图片或其他第三方材料均包含在文章的知识共享许可协议中,除非在材料的署名栏中另有说明。如果材料未包含在文章的知识共享许可协议中,且您打算使用的材料不符合法律规定或超出许可
{"title":"Development of innovative tripartite partnership for China’s engagement in global health: recommendations from China-Tanzania Cooperation Project on Malaria Control","authors":"Xuejiao Ma, Shenning Lu, Wei Ding, Shanying Deng, Duoquan Wang, Ning Xiao, Yeromin Mlacha, Lewis Husain, Xiaonong Zhou","doi":"10.1186/s40249-024-01178-4","DOIUrl":"https://doi.org/10.1186/s40249-024-01178-4","url":null,"abstract":"<p>Tripartite partnership, compared with the bilateral model, is envisioned as an opportunity to foster stronger and more trusting partnerships [1]. However, China has historically been characterized as principally reliant on bilateral engagement in global health [2]. The China-Tanzania Cooperation Project on Malaria Control was conducted by National Institute of Parasitic Diseases at China CDC and Chinese Center for Tropical Diseases Research, Ifakara Health Institute in Tanzania and funding agencies from 2015 to 2022, with an aim to explore the applicability of Chinese experience on malaria control to reduce malaria disease burden in the local context of Tanzania. In the tripartite project funded by the former UK Department for International Development (DFID) and later the Bill &amp; Melinda Gates Foundation (BMGF), China’s partners were expected to share the extensively parallel practices achieved from the control and elimination of malaria for over 70 years, UK’s partners were to deliver resources and design global health strategies, while Tanzanian local staff collaborated with triangular partners to ensure the project implementation [3]. In the project, the trilateral cooperation has transparent management mechanism to ensure the concrete management and implementation of the project [4] (Additional file 1: Figure S1). This Brief is to provide recommendations for China’s engagement in global health by distilling the experience from the innovative tripartite partnership of the project.</p><p>Impressive achievements were made through the pioneering efforts of triangular stakeholders of the project: (1) 1,7-malaria Reactive Community-based Testing and Response (1,7-mRCTR) was successfully derived from local context sharing Chinese 1-3-7 norm through the field implementation; (2) malaria prevalence in the intervention wards declined by 81% from 2015 to 2018 and further declined by 55% from 2018 to 2022 [3]; (3) a local team composed of 37 Tanzanian community health workers were built to be paired with Chinese on-site technical staff to ensure the project implementation and sustainability[3]; (4) the project’s effectiveness and achievements contributed to the scaling up of 1,7-mRCTR in three other African countries including Burkina Faso, Senegal, and Zambia for sustainable development [4].</p><p>The project also encountered some challenges in this trilateral partnership, (1) China’s immature systems for global health engagement with scarce resources allocated to this innovative partnership [5], e.g. the complicated procedures of funding transfer from China to Tanzania, the time-consuming visa application for Chinese staff’s field support, and the scarce resources. Therefore, it is essential to mobilize resources for the trilateral collaboration with developing a solid system for China’s participation in global health. In order to effectively mobilize resources for these trilateral collaborations, it is imperative to develop a robust logistics s","PeriodicalId":13587,"journal":{"name":"Infectious Diseases of Poverty","volume":null,"pages":null},"PeriodicalIF":8.1,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140033618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward tuberculosis elimination by understanding epidemiologic characteristics and risk factors in Hainan Province, China 通过了解中国海南省的流行病学特征和风险因素,努力消除结核病
IF 8.1 1区 医学 Q1 Medicine Pub Date : 2024-02-27 DOI: 10.1186/s40249-024-01188-2
Changqiang Zhou, Tao Li, Jian Du, Dapeng Yin, Xiujun Li, Shixue Li
The disease burden of tuberculosis (TB) was heavy in Hainan Province, China, and the information on transmission patterns was limited with few studies. This atudy aims to further explore the epidemiological characteristics and influencing factors of TB in Hainan Province, and thereby contribute valuable scientific evidences for TB elimination in Hainan Province. The TB notification data in Hainan Province from 2013 to 2022 were collected from the Chinese National Disease Control Information System Tuberculosis Surveillance System, along with socio-economic data. The spatial–temporal and population distributions were analyzed, and spatial autocorrelation analysis was conducted to explore TB notification rate clustering. In addition, the epidemiological characteristics of the cases among in-country migrants were described, and the delay pattern in seeking medical care was investigated. Finally, a geographically and temporally weighted regression (GTWR) model was adopted to analyze the relationship between TB notification rate and socio-economic indicators. The tailored control suggestions in different regions for TB elimination was provided by understanding epidemiological characteristics and risk factors obtained by GTWR. From 2013 to 2022, 64,042 cases of TB were notified in Hainan Province. The estimated annual percentage change of TB notification rate in Hainan Province from 2013 to 2020 was − 6.88% [95% confidence interval (CI): − 5.30%, − 3.69%], with higher rates in central and southern regions. The majority of patients were males (76.33%) and farmers (67.80%). Cases among in-country migrants primarily originated from Sichuan (369 cases), Heilongjiang (267 cases), Hunan (236 cases), Guangdong (174 cases), and Guangxi (139 cases), accounting for 53%. The majority (98.83%) of TB cases were notified through passive case finding approaches, with delay in seeking care. The GTWR analysis showed that gross domestic product per capita, the number of medical institutions and health personnel per 10,000 people were main factors affecting the high TB notification rates in some regions in Hainan Province. Different regional tailored measures such as more TB specialized hospitals were proposed based on the characteristics of each region. The notification rate of TB in Hainan Province has been declining overall but still remained high in central and southern regions. Particular attention should be paid to the prevalence of TB among males, farmers, and out-of-province migrant populations. The notification rate was also influenced by economic development and medical conditions, indicating the need of more TB specialized hospitals, active surveillance and other tailored prevention and control measures to promote the progress of TB elimination in Hainan Province.
中国海南省结核病(TB)疾病负担沉重,而有关传播模式的信息有限,研究较少。本研究旨在进一步探讨海南省结核病的流行病学特征和影响因素,从而为海南省消除结核病提供有价值的科学依据。本研究从中国国家疾病控制信息系统结核病监测系统中收集了海南省 2013 年至 2022 年的结核病报告数据以及社会经济数据。分析了结核病的时空分布和人口分布,并通过空间自相关分析探讨了结核病通报率的聚集性。此外,还描述了国内移民病例的流行病学特征,并调查了就医延迟模式。最后,采用地理和时间加权回归(GTWR)模型分析了结核病通报率与社会经济指标之间的关系。通过了解GTWR得出的流行病学特征和风险因素,为不同地区消除结核病提供了有针对性的控制建议。2013年至2022年,海南省共报告肺结核病例64042例。2013年至2020年,海南省结核病报告率的估计年百分比变化为-6.88%[95%置信区间(CI):-5.30%,-3.69%],中部和南部地区的报告率较高。大多数患者为男性(76.33%)和农民(67.80%)。国内移民中的病例主要来自四川(369 例)、黑龙江(267 例)、湖南(236 例)、广东(174 例)和广西(139 例),占 53%。大多数(98.83%)肺结核病例是通过被动病例发现的方式报告的,存在就诊延迟的情况。GTWR 分析显示,人均国内生产总值、医疗机构数量和每万人卫生人员数是影响海南省部分地区结核病高报告率的主要因素。根据各地区的特点,提出了不同的地区性措施,如增加结核病专科医院等。海南省结核病报告率总体呈下降趋势,但中部和南部地区仍居高不下。应特别关注男性、农民和省外流动人口中结核病的流行情况。通知率还受到经济发展和医疗条件的影响,这表明需要更多的结核病专科医院、主动监测和其他有针对性的防控措施,以促进海南省消除结核病工作的进展。
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引用次数: 0
Chromosome-level genome assembly of Oncomelania hupensis: the intermediate snail host of Schistosoma japonicum 日本血吸虫中间蜗牛宿主Oncomelania hupensis的染色体级基因组组装
IF 8.1 1区 医学 Q1 Medicine Pub Date : 2024-02-27 DOI: 10.1186/s40249-024-01187-3
Qin Liu, Lei Duan, Yun-Hai Guo, Li-Min Yang, Yi Zhang, Shi-Zhu Li, Shan Lv, Wei Hu, Nan-Sheng Chen, Xiao-Nong Zhou
Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China, the Philippines and Indonesia. Oncomelania hupensis (Gastropoda: Pomatiopsidae) is the unique intermediate host of S. japonicum. A complete genome sequence of O. hupensis will enable the fundamental understanding of snail biology as well as its co-evolution with the S. japonicum parasite. Assembling a high-quality reference genome of O. hupehensis will provide data for further research on the snail biology and controlling the spread of S. japonicum. The draft genome was de novo assembly using the long-read sequencing technology (PacBio Sequel II) and corrected with Illumina sequencing data. Then, using Hi-C sequencing data, the genome was assembled at the chromosomal level. CAFE was used to do analysis of contraction and expansion of the gene family and CodeML module in PAML was used for positive selection analysis in protein coding sequences. A total length of 1.46 Gb high-quality O. hupensis genome with 17 unique full-length chromosomes (2n = 34) of the individual including a contig N50 of 1.35 Mb and a scaffold N50 of 75.08 Mb. Additionally, 95.03% of these contig sequences were anchored in 17 chromosomes. After scanning the assembled genome, a total of 30,604 protein-coding genes were predicted. Among them, 86.67% were functionally annotated. Further phylogenetic analysis revealed that O. hupensis was separated from a common ancestor of Pomacea canaliculata and Bellamya purificata approximately 170 million years ago. Comparing the genome of O. hupensis with its most recent common ancestor, it showed 266 significantly expanded and 58 significantly contracted gene families (P < 0.05). Functional enrichment of the expanded gene families indicated that they were mainly involved with intracellular, DNA-mediated transposition, DNA integration and transposase activity. Integrated use of multiple sequencing technologies, we have successfully constructed the genome at the chromosomal-level of O. hupensis. These data will not only provide the compressive genomic information, but also benefit future work on population genetics of this snail as well as evolutional studies between S. japonicum and the snail host.
日本血吸虫是一种导致人类血吸虫病的寄生扁虫,是中国、菲律宾和印度尼西亚的主要致病原因。日本血吸虫的独特中间宿主是蛇尾蝇(腹足纲:蛇尾蝇科)。获得 O. hupensis 的完整基因组序列将有助于从根本上了解蜗牛生物学及其与日本蜗牛寄生虫的共同进化。组装一个高质量的O. hupehensis参考基因组将为进一步研究蜗牛生物学和控制日本蜗牛传播提供数据。利用长线程测序技术(PacBio Sequel II)从头组装了基因组草案,并用 Illumina 测序数据进行了校正。然后,利用 Hi-C 测序数据在染色体水平上组装了基因组。CAFE 用于分析基因家族的收缩和扩展,PAML 中的 CodeML 模块用于蛋白质编码序列的正选择分析。总长度为 1.46 Gb 的高质量 O. hupensis 基因组包含 17 条独特的全长染色体(2n = 34),其中等位基因 N50 为 1.35 Mb,支架 N50 为 75.08 Mb。此外,95.03% 的等位基因序列锚定在 17 条染色体上。在扫描组装后的基因组后,共预测出 30,604 个蛋白质编码基因。其中,86.67%的基因得到了功能注释。进一步的系统发育分析表明,O. hupensis 是在大约 1.7 亿年前从 Pomacea canaliculata 和 Bellamya purificata 的共同祖先分离出来的。将 O. hupensis 的基因组与其最近的共同祖先进行比较,结果显示 266 个基因家族明显扩大,58 个基因家族明显缩小(P < 0.05)。扩增基因家族的功能富集表明,它们主要参与细胞内、DNA介导的转座、DNA整合和转座酶活性。综合利用多种测序技术,我们成功构建了O. hupensis染色体水平的基因组。这些数据不仅提供了压缩的基因组信息,还有利于今后对该蜗牛种群遗传学的研究以及日本蜗牛与宿主之间的进化研究。
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引用次数: 0
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Infectious Diseases of Poverty
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