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Who stays? Understanding the attrition in a longitudinal aging study of older Chinese immigrants in the United States. 谁停留?了解在美国的中国老年移民的纵向老龄化研究中的损耗。
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-14 eCollection Date: 2025-10-01 DOI: 10.1093/geroni/igaf098
Yanping Jiang, Yuyang Zhu, Stephanie Bergren, Wendi Da, Dexia Kong, Fengyan Tang

Background and objectives: Despite the rapid growth of older Asian American populations, little is known about their retention and its associated factors in longitudinal aging studies, partially due to the limited longitudinal studies among this population. This study addresses this critical gap by examining key predictors of attrition in this understudied population.

Research design and methods: Using data from the Population Study of Chinese Elderly in Chicago (PINE), a large longitudinal epidemiological study of older Chinese immigrants in the United States (US), we analyzed the effect of sociodemographic, immigration, health, and psychosocial characteristics on attrition status and various attrition patterns.

Results: High levels of acculturation and longer length of stay in the US were associated with a higher likelihood of attrition. Also, participants with higher levels of educational attainment and loneliness were more likely to drop out of the study earlier. In addition, participants with lower income were more likely to remain in the study.

Discussion and implications: These results show unique attrition dynamics in older Asian immigrants, where acculturation and education paradoxically increase attrition risk. These findings highlight the need for tailored retention strategies to enhance continued participation in longitudinal aging studies among older Asian American immigrants.

背景和目的:尽管老年亚裔美国人人口增长迅速,但在纵向老龄化研究中,对他们的保留及其相关因素知之甚少,部分原因是该人群的纵向研究有限。本研究通过研究这一未被充分研究的人群中流失的关键预测因素来解决这一关键差距。研究设计和方法:利用芝加哥华人老年人口研究(PINE)的数据,分析了社会人口学、移民、健康和心理社会特征对流失状况和各种流失模式的影响。PINE是一项针对美国老年华人移民的大型纵向流行病学研究。结果:高水平的文化适应和在美国停留的时间越长,人员流失的可能性越高。此外,受教育程度和孤独感较高的参与者更有可能提前退出研究。此外,收入较低的参与者更有可能留在研究中。讨论和启示:这些结果显示了亚洲老年移民独特的流失动态,其中文化适应和教育矛盾地增加了流失风险。这些发现强调需要量身定制的保留策略,以加强对老年亚裔美国移民纵向老龄化研究的持续参与。
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引用次数: 0
From curing to caring: exploring social care needs after the onset of chronic conditions among European older adults (50+). 从治疗到护理:探索欧洲老年人(50岁以上)慢性病发病后的社会护理需求。
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-14 eCollection Date: 2025-01-01 DOI: 10.1093/geroni/igaf085
Mariana Calderón-Jaramillo, Elisenda Rentería, Jeroen Spijker

Background and objectives: Population aging affects health and social care needs. Although its effects on healthcare needs have been widely discussed, less has been said about its implications on social care needs, even though the consequences of living with chronic conditions are related to functional decline, disability, dependency, and mobility limitation. This study aims to identify trajectories of healthcare and social care needs after the onset of chronic conditions, as well as to explore through cross-country comparisons how demographic, socioeconomic, living arrangements, and health-related dimensions explain individuals' trajectories.

Research design and methods: Using data from the Survey of Health, Ageing and Retirement in Europe, we analyzed trajectories of 16,718 individuals aged 50 and above from 10 European countries through sequence analysis. Multinomial regression models were fitted to understand the factors that explained these trajectories.

Results: This study identified four trajectories after the onset of chronic conditions: (a) "Persistent multimorbidity and social care needs," (b) "Persistent multimorbidity without social care needs," (c) "One chronic condition and social care needs," and (d) "One chronic condition without social care needs and some recoveries." The models present divergences in individuals' characteristics, including demographic and socioeconomic aspects, as well as differences by country, related to each trajectory.

Discussion and implications: By acknowledging trajectories within health and social care needs, we showed the challenges posed by aging processes, which require tailored-made and person-centered services oriented towards preventing and postponing the onset of chronic conditions as well as dealing with their consequences on individuals' daily lives.

背景和目标:人口老龄化影响健康和社会护理需求。尽管慢性病对医疗保健需求的影响已被广泛讨论,但其对社会护理需求的影响却很少被提及,尽管慢性病患者的生活后果与功能下降、残疾、依赖和行动受限有关。本研究旨在确定慢性病发病后的医疗保健和社会护理需求轨迹,并通过跨国比较探索人口、社会经济、生活安排和健康相关维度如何解释个人的轨迹。研究设计和方法:我们利用欧洲健康、老龄化和退休调查的数据,通过序列分析分析了来自10个欧洲国家的16718名50岁及以上的个人的轨迹。采用多项回归模型来理解解释这些轨迹的因素。结果:本研究确定了慢性疾病发病后的四种轨迹:(a)“持续性多重疾病和社会护理需求”;(b)“持续性多重疾病没有社会护理需求”;(c)“单一慢性疾病和社会护理需求”;(d)“单一慢性疾病没有社会护理需求和一些康复”。这些模型显示了个人特征的差异,包括人口和社会经济方面的差异,以及与每个轨迹相关的国家差异。讨论和影响:通过承认健康和社会护理需求的轨迹,我们展示了老龄化进程带来的挑战,这需要量身定制和以人为本的服务,以预防和推迟慢性病的发作,并处理其对个人日常生活的影响。
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引用次数: 0
Feasibility and acceptability of WeCare Mentoring, an online peer mentoring program for aged care support workers. 老年护理工作者在线同伴辅导项目WeCare Mentoring的可行性与可接受性。
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI: 10.1093/geroni/igaf094
Karol J Czuba, Alain C Vandal, Nicola M Kayes

Background and objectives: In recognition of the aging population and aged care workforce shortages, calls have been made for responsive and effective strategies for this workforce group. This study aimed to investigate the feasibility, acceptability, and preliminary efficacy of an online mentoring program for aged care support workers serving older adults in New Zealand residential care facilities.

Research design and methods: This mixed-methods study consisted of (1) a nonrandomized single-arm intervention study, with outcome measurement at baseline, 3- and 6-month (Satisfaction with Life Scale, Generic Job Satisfaction, Perceived Stress Scale, and General Self-Efficacy Scale) and (2) a post-intervention qualitative descriptive study exploring perceived acceptability and feasibility aspects of the proposed intervention. Participants met once a month, for 30-60 min. They followed a program manual to work on self-identified goals.

Results: Thirty-eight support workers enrolled, and 22 of them took part and completed the 6-month program. The recruitment target was reached within the proposed 3-month timeframe. Data collection procedures were considered practical and convenient. Participants (13 mentees and 9 mentors) reported that the program was appealing and relevant, its duration and intensity appropriate, and the online delivery acceptable. Participants proposed refinements to improve their experience further. Exploratory outcomes analysis found all measures trended in the expected direction.

Discussion and implications: The WeCare Mentoring Program was found to be a feasible and acceptable intervention. Participants reported several improvements in their well-being and their caregiving-related skills. The next step is to test the intervention's effectiveness in a definitive controlled trial or quasi-experimental study. If future efficacy trials prove successful, this program can offer a much-needed support to the aged care workforce, and lead to better outcomes for them and the people they care for.

背景和目标:认识到人口老龄化和老年护理人员短缺,已经呼吁为这一劳动力群体制定响应和有效的战略。本研究旨在探讨在线辅导计划的可行性、可接受性及初步效果,以协助纽西兰居家照护机构的长者护理支援人员。研究设计和方法:这项混合方法研究包括:(1)一项非随机单臂干预研究,在基线、3个月和6个月(生活满意度量表、一般工作满意度量表、感知压力量表和一般自我效能量表)进行结果测量;(2)一项干预后定性描述性研究,探索所提出干预措施的感知可接受性和可行性方面。参与者每月会面一次,每次30-60分钟。他们遵循一个程序手册来实现自己确定的目标。结果:38名支持工作者入组,其中22人参加并完成了为期6个月的项目。在提议的3个月时间框架内达到了征聘目标。数据收集程序被认为是实用和方便的。参与者(13名学员和9名导师)报告说,该计划具有吸引力和相关性,其持续时间和强度合适,在线交付可以接受。与会者提出了改进意见,以进一步改善他们的体验。探索性结果分析发现,所有测量结果均符合预期方向。讨论与启示:我们发现我们的辅导计划是一个可行且可接受的干预措施。参与者报告说,他们的幸福感和护理相关技能有所改善。下一步是在一项明确的对照试验或准实验研究中测试干预措施的有效性。如果未来的疗效试验证明是成功的,这个项目可以为老年护理人员提供急需的支持,并为他们和他们所照顾的人带来更好的结果。
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引用次数: 0
How social engagement shapes depressive symptoms in later life: uncovering gendered and asymmetric effects. 社会参与如何影响晚年的抑郁症状:揭示性别和不对称的影响。
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI: 10.1093/geroni/igaf096
Jinho Kim, Keun Young Kwon

Background and objectives: Social engagement is widely recognized as a protective factor for mental health in later life, yet most studies treat it as a static condition and overlook potential asymmetries in the effects of becoming socially engaged and disengaged. This study examines (1) whether the mental health effects of entering and exiting social engagement are asymmetric, (2) whether these effects differ by the type of engagement (informal vs formal), and (3) whether gender moderates these associations.

Research design and methods: Using 7 waves of data from the Korean Longitudinal Study of Aging, we analyzed 6,762 older adults aged 65 and older. Asymmetric fixed effects models were employed to estimate within-person changes in depressive symptoms associated with entry into and exit from social engagement. Gender-stratified models and interaction terms were used to examine differential effects by gender.

Results: Transitions into and out of social engagement were significantly associated with changes in depressive symptoms, but no statistically significant asymmetries were found for either informal or formal engagement in the full sample. However, gender-stratified analyses revealed asymmetric effects for formal social engagement: women benefited more from entering engagement, whereas men were more negatively affected by exiting it. No gender differences or asymmetries were observed for informal social engagement.

Discussion and implications: These findings underscore the importance of distinguishing between types of social engagement and considering gender differences when designing interventions. Policies that support both prevention and re-engagement-particularly those that are gender-sensitive and address formal social roles-may be most effective in promoting mental health among older adults.

背景和目的:社会参与被广泛认为是晚年心理健康的一个保护因素,然而大多数研究将其视为一个静态条件,忽视了参与和脱离社会的潜在不对称影响。本研究探讨了(1)进入和退出社会参与对心理健康的影响是否不对称,(2)这些影响是否因参与类型(非正式与正式)而异,以及(3)性别是否调节了这些关联。研究设计与方法:采用韩国老龄化纵向研究的7波数据,对6762名65岁及以上的老年人进行分析。采用不对称固定效应模型来估计与进入和退出社交活动相关的抑郁症状的个人内部变化。使用性别分层模型和相互作用术语来检查性别的差异效应。结果:进入和退出社会参与与抑郁症状的变化显著相关,但在整个样本中,非正式或正式参与都没有发现统计学上显著的不对称。然而,性别分层分析揭示了正式社会参与的不对称效应:女性从参与中获益更多,而男性则因退出而受到更大的负面影响。在非正式社会参与方面没有观察到性别差异或不对称。讨论和启示:这些发现强调了在设计干预措施时区分社会参与类型和考虑性别差异的重要性。支持预防和重新参与的政策,特别是那些对性别问题有敏感认识和处理正式社会角色的政策,在促进老年人心理健康方面可能是最有效的。
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引用次数: 0
Bidirectional transitions of frailty states among middle-aged and older adults: a longitudinal cohort analysis using a multi-state Markov model based on the China Health and Retirement Longitudinal Study. 中老年人虚弱状态的双向转变:基于中国健康与退休纵向研究的多状态马尔可夫模型纵向队列分析
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI: 10.1093/geroni/igaf095
Ye Tong, Yiling Teng, Yujie Zhang, Changming Huang, Weiliang Liao, Baicheng Wan, Shaohui Zong, Gaofeng Zeng

Background and objectives: Frailty is a dynamic syndrome increasing older adults' vulnerability to adverse outcomes. Longitudinal data on frailty transitions and their influencing factors remain limited. We aimed to examine bidirectional frailty transitions among middle-aged and older adults using a multi-state Markov (MSM) model.

Research design and methods: Data were obtained from four waves (2011-2018) of the China Health and Retirement Longitudinal Study (CHARLS), including 15 763 participants aged ≥45 years. Frailty was assessed using a 32-item frailty index. MSM models estimated transition probabilities, mean sojourn times, and covariate effects. Additional analyses examined age- and gender-specific patterns and included an age × gender interaction term.

Results: Baseline prevalence of robust, pre-frail, and frail states was 44.3%, 39.4%, and 16.3%, respectively. Within one year, pre-frail participants had probabilities of 18.0% reverting to robust and 19.7% progressing to frail states. At five years, these probabilities were 23.4% and 33.4%, respectively, with mortality increasing to 19.7%. Older age increased frailty progression and mortality risks but reduced recovery likelihood. Notably, significant age × gender interactions were observed for transitions from pre-frail to robust and from frail to death. Men showed higher recovery rates but greater frailty-related mortality than women. Urban residency, higher education, and marriage were protective, while smoking and alcohol increased frailty risk.

Discussion and implications: Frailty among middle-aged and older Chinese adults demonstrates substantial bidirectional transitions, indicating notable opportunities for intervention and prevention. Age, gender, socioeconomic status, and lifestyle behaviors are key modifiable determinants influencing frailty progression and recovery. Public health strategies prioritizing targeted screening and preventive interventions-particularly among vulnerable groups-could effectively mitigate frailty progression, promote recovery, and improve overall population health outcomes.

背景和目的:虚弱是一种动态综合征,增加了老年人对不良后果的脆弱性。关于脆弱性转变及其影响因素的纵向数据仍然有限。我们的目的是使用多状态马尔可夫(MSM)模型来检查中老年人的双向脆弱转变。研究设计和方法:数据来自中国健康与退休纵向研究(CHARLS)的四波(2011-2018),包括15 763名年龄≥45岁的参与者。虚弱程度采用32项虚弱指数进行评估。MSM模型估计转移概率、平均逗留时间和协变量效应。额外的分析检查了年龄和性别特定的模式,并包括一个年龄×性别相互作用的术语。结果:健康、预虚弱和虚弱状态的基线患病率分别为44.3%、39.4%和16.3%。在一年内,身体虚弱的参与者恢复健康的概率为18.0%,进入虚弱状态的概率为19.7%。5年后,这些概率分别为23.4%和33.4%,死亡率增加到19.7%。老年增加了衰弱进展和死亡风险,但降低了康复的可能性。值得注意的是,在从体弱到健壮和从体弱到死亡的转变中,观察到显著的年龄与性别的相互作用。与女性相比,男性的康复率更高,但与虚弱相关的死亡率更高。城市居住、高等教育和婚姻是保护因素,而吸烟和饮酒则增加了患病风险。讨论和启示:中国中老年人的虚弱表现出实质性的双向转变,表明干预和预防的显著机会。年龄、性别、社会经济地位和生活方式行为是影响虚弱进展和恢复的关键因素。公共卫生战略优先考虑有针对性的筛查和预防性干预,特别是在弱势群体中,可以有效地减缓虚弱的进展,促进康复,并改善总体人口健康结果。
{"title":"Bidirectional transitions of frailty states among middle-aged and older adults: a longitudinal cohort analysis using a multi-state Markov model based on the China Health and Retirement Longitudinal Study.","authors":"Ye Tong, Yiling Teng, Yujie Zhang, Changming Huang, Weiliang Liao, Baicheng Wan, Shaohui Zong, Gaofeng Zeng","doi":"10.1093/geroni/igaf095","DOIUrl":"10.1093/geroni/igaf095","url":null,"abstract":"<p><strong>Background and objectives: </strong>Frailty is a dynamic syndrome increasing older adults' vulnerability to adverse outcomes. Longitudinal data on frailty transitions and their influencing factors remain limited. We aimed to examine bidirectional frailty transitions among middle-aged and older adults using a multi-state Markov (MSM) model.</p><p><strong>Research design and methods: </strong>Data were obtained from four waves (2011-2018) of the China Health and Retirement Longitudinal Study (CHARLS), including 15 763 participants aged ≥45 years. Frailty was assessed using a 32-item frailty index. MSM models estimated transition probabilities, mean sojourn times, and covariate effects. Additional analyses examined age- and gender-specific patterns and included an age × gender interaction term.</p><p><strong>Results: </strong>Baseline prevalence of robust, pre-frail, and frail states was 44.3%, 39.4%, and 16.3%, respectively. Within one year, pre-frail participants had probabilities of 18.0% reverting to robust and 19.7% progressing to frail states. At five years, these probabilities were 23.4% and 33.4%, respectively, with mortality increasing to 19.7%. Older age increased frailty progression and mortality risks but reduced recovery likelihood. Notably, significant age × gender interactions were observed for transitions from pre-frail to robust and from frail to death. Men showed higher recovery rates but greater frailty-related mortality than women. Urban residency, higher education, and marriage were protective, while smoking and alcohol increased frailty risk.</p><p><strong>Discussion and implications: </strong>Frailty among middle-aged and older Chinese adults demonstrates substantial bidirectional transitions, indicating notable opportunities for intervention and prevention. Age, gender, socioeconomic status, and lifestyle behaviors are key modifiable determinants influencing frailty progression and recovery. Public health strategies prioritizing targeted screening and preventive interventions-particularly among vulnerable groups-could effectively mitigate frailty progression, promote recovery, and improve overall population health outcomes.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"9 12","pages":"igaf095"},"PeriodicalIF":4.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12685369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The attitudes and acceptance of functional assistive robots among older adults with disabilities: a mixed-methods study. 残疾老年人对功能性辅助机器人的态度和接受:一项混合方法研究。
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI: 10.1093/geroni/igaf097
Yilin Wang, Hongxiu Chen, Hong Cheng, Jing Qiu, Rui Huang, Chaobin Zou, Guangkui Song, Menghong Liu, Qian Liu, Jiali Zhang, Xiuying Hu

Background and objectives: The growth in older adults living with disabilities and the decline in the workforce call for technology-driven nursing services to alleviate the burden. Functional assistive robots have emerged as a promising solution; however, their acceptance and attitude toward them remain underexplored. Therefore, this study aimed to investigate the attitudes and requirements of older adults living with disabilities regarding functional assistive robots.

Research design and methods: A mixed-methods study was conducted between November 2023 and January 2024, comprising a cross-sectional survey of 85 older adults with varying levels of disability and semi-structured interviews with 10 participants. Quantitative data were analyzed descriptively, and qualitative data were thematically analyzed to enrich and contextualize the findings.

Results: Fifty-three percent of participants expressed willingness to use a functional assistive robot, with safety, affordability, ease of use, and multifunctionality identified as the most influential factors. Walking assistance and toilet transfer were the most desired functions across all disability levels. Qualitative findings reinforced the quantitative findings, revealing dissatisfaction with current aids due to their limited stability and maneuverability, alongside a strong desire for increased independence and reduced strain on family caregivers. Attitudes toward robots ranged from enthusiasm to skepticism, influenced by perceived usefulness, disability level, and care context. Participants emphasized the need for compact, stable designs with simple interfaces, and some expressed interest in light social features, provided they did not compromise core functionality.

Discussion and implications: This study highlights the demand for functional assistive robots that address critical mobility-related tasks. Functional assistive robots are viewed as promising, but adoption hinges on improving safety, usability, and affordability. Multifunctional, user-friendly designs are essential for practical use. The findings offer guidance for nurses, caregivers, and developers by clarifying core functional needs and concerns, supporting the creation of acceptable technologies that enhance autonomy and quality of life.

背景和目标:残疾老年人的增长和劳动力的减少要求技术驱动的护理服务来减轻负担。功能性辅助机器人已经成为一种很有前途的解决方案;然而,他们的接受程度和对他们的态度仍然没有得到充分的研究。因此,本研究旨在调查残疾老年人对功能性辅助机器人的态度和要求。研究设计和方法:一项混合方法研究于2023年11月至2024年1月进行,包括对85名残疾程度不同的老年人的横断面调查和对10名参与者的半结构化访谈。定量数据进行描述性分析,定性数据进行主题分析,以丰富和背景研究结果。结果:53%的参与者表示愿意使用功能性辅助机器人,其中安全性、可负担性、易用性和多功能被认为是最具影响力的因素。行走辅助和厕所转移是所有残疾级别中最需要的功能。定性调查结果强化了定量调查结果,揭示了对当前辅助工具的不满,因为它们的稳定性和可操作性有限,同时强烈希望增加独立性,减少家庭照顾者的压力。对机器人的态度从热情到怀疑不等,受感知有用性、残疾程度和护理环境的影响。与会者强调需要紧凑、稳定的设计和简单的界面,一些人表示对轻社交功能感兴趣,只要他们不损害核心功能。讨论和启示:这项研究强调了对功能性辅助机器人的需求,这些机器人可以解决关键的移动相关任务。功能性辅助机器人被认为是很有前途的,但采用与否取决于提高安全性、可用性和可负担性。多功能、用户友好的设计对于实际使用是必不可少的。研究结果通过阐明核心功能需求和关注点,为护士、护理人员和开发人员提供指导,支持开发可接受的技术,提高自主性和生活质量。
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引用次数: 0
Age-friendly AI: building bridges between technology and geriatric care. 对老年人友好的人工智能:在技术和老年护理之间架起桥梁。
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-09-08 eCollection Date: 2025-12-01 DOI: 10.1093/geroni/igaf093
Thomas K M Cudjoe, Katherine Feemster, Sato Ashida, Peter Abadir, Phillip Phan, Nancy L Schoenborn
{"title":"Age-friendly AI: building bridges between technology and geriatric care.","authors":"Thomas K M Cudjoe, Katherine Feemster, Sato Ashida, Peter Abadir, Phillip Phan, Nancy L Schoenborn","doi":"10.1093/geroni/igaf093","DOIUrl":"10.1093/geroni/igaf093","url":null,"abstract":"","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"9 Suppl 1","pages":"S33-S37"},"PeriodicalIF":4.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12742840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145850092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining the relationship between cardiometabolic risk factors and telomere length in women: a systematic review. 检查女性心脏代谢危险因素与端粒长度之间的关系:一项系统综述。
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-08-25 eCollection Date: 2025-01-01 DOI: 10.1093/geroni/igaf091
Jeni Page, Catherine Stephens, Melissa A Richard, Elizabeth Lyons, Elizabeth Baumler, M Terese Verklan, Elizabeth Lorenzo

Background and objectives: Cardiometabolic syndrome (CMS) poses a significant public health challenge due to its rising prevalence in aging and significant healthcare costs. Recent studies have suggested telomere length (TL), a marker of cellular aging, may be impacted by CMS among women, but comprehensive evidence remains limited. This study aimed to examine the association between CMS risk factors (increased waist circumference [WC], elevated blood pressure, impaired fasting blood glucose, elevated triglycerides, decreased high-density lipoproteins) and TL in women, with consideration of age and race or ethnicity.

Research design and methods: A systematic review was conducted following PRISMA guidelines, with searches across five databases. Thirteen relevant studies published between 2007 and 2022 were included. A narrative synthesis was performed to evaluate associations between CMS risk factors and TL.

Results: Findings revealed individual CMS risk factors did not demonstrate relationships with TL; however, a link was identified between collective CMS risk factors and decreased TL. The influence of CMS on TL varied by mean sample age, where increased WC was associated with decreased TL for middle adulthood women. Findings based on race or ethnicity were inconclusive due to limited analyses, but examination by continent revealed a relationship between increased WC and decreased TL in Asia and North America.

Discussion and implications: There was high heterogeneity among diagnostic criteria for CMS risk factors across studies, potentially limiting findings. This review highlights the need for further research to clarify the complex associations between CMS and TL in women throughout the lifespan. Future large cohort studies using standardized CMS diagnostic criteria should examine variations by age and race or ethnicity to enhance understanding of these relationships.

背景和目的:心血管代谢综合征(CMS)由于其在老年人中患病率上升和医疗保健费用高,对公共卫生构成了重大挑战。最近的研究表明,端粒长度(TL),细胞老化的标志,可能受到CMS女性的影响,但全面的证据仍然有限。本研究旨在探讨CMS危险因素(腰围增加、血压升高、空腹血糖受损、甘油三酯升高、高密度脂蛋白降低)与女性TL之间的关系,并考虑年龄和种族或民族。研究设计和方法:根据PRISMA指南进行了系统的评价,检索了五个数据库。收录了2007年至2022年间发表的13项相关研究。结果:单个CMS危险因素与TL之间没有关系;然而,集体CMS风险因素与TL下降之间存在联系。CMS对TL的影响因平均样本年龄而异,其中中年女性WC增加与TL下降相关。由于分析有限,基于种族或民族的研究结果尚无定论,但根据大陆进行的研究显示,亚洲和北美的WC增加和TL减少之间存在关系。讨论和意义:研究中CMS危险因素的诊断标准存在高度异质性,可能限制研究结果。这篇综述强调需要进一步的研究来阐明女性一生中CMS和TL之间的复杂关系。未来使用标准化CMS诊断标准的大型队列研究应检查年龄和种族或民族的变化,以加强对这些关系的理解。
{"title":"Examining the relationship between cardiometabolic risk factors and telomere length in women: a systematic review.","authors":"Jeni Page, Catherine Stephens, Melissa A Richard, Elizabeth Lyons, Elizabeth Baumler, M Terese Verklan, Elizabeth Lorenzo","doi":"10.1093/geroni/igaf091","DOIUrl":"10.1093/geroni/igaf091","url":null,"abstract":"<p><strong>Background and objectives: </strong>Cardiometabolic syndrome (CMS) poses a significant public health challenge due to its rising prevalence in aging and significant healthcare costs. Recent studies have suggested telomere length (TL), a marker of cellular aging, may be impacted by CMS among women, but comprehensive evidence remains limited. This study aimed to examine the association between CMS risk factors (increased waist circumference [WC], elevated blood pressure, impaired fasting blood glucose, elevated triglycerides, decreased high-density lipoproteins) and TL in women, with consideration of age and race or ethnicity.</p><p><strong>Research design and methods: </strong>A systematic review was conducted following PRISMA guidelines, with searches across five databases. Thirteen relevant studies published between 2007 and 2022 were included. A narrative synthesis was performed to evaluate associations between CMS risk factors and TL.</p><p><strong>Results: </strong>Findings revealed individual CMS risk factors did not demonstrate relationships with TL; however, a link was identified between collective CMS risk factors and decreased TL. The influence of CMS on TL varied by mean sample age, where increased WC was associated with decreased TL for middle adulthood women. Findings based on race or ethnicity were inconclusive due to limited analyses, but examination by continent revealed a relationship between increased WC and decreased TL in Asia and North America.</p><p><strong>Discussion and implications: </strong>There was high heterogeneity among diagnostic criteria for CMS risk factors across studies, potentially limiting findings. This review highlights the need for further research to clarify the complex associations between CMS and TL in women throughout the lifespan. Future large cohort studies using standardized CMS diagnostic criteria should examine variations by age and race or ethnicity to enhance understanding of these relationships.</p>","PeriodicalId":13596,"journal":{"name":"Innovation in Aging","volume":"9 9","pages":"igaf091"},"PeriodicalIF":4.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex- and age-specific multimorbidity networks in middle-aged inpatients: a network-based comparative study between China and the United Kingdom. 中年住院患者性别和年龄特异性多病网络:中英两国基于网络的比较研究
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-08-18 eCollection Date: 2025-01-01 DOI: 10.1093/geroni/igaf090
Yining Bao, Hanting Liu, Qianhui Lu, Yang Sun, Lin Wang, Shu Su, Pengyi Lu, Mengjie Wang, Ting Ma, Xinxin Xie, Wenhua Wang, Liqin Wang, Yuhang Zhai, Fang Lu, Yudong Wei, Rui Li, Miao Ding, Yiqi Yan, Shiwei Jia, Xueli Zhang, Jiangcun Yang, Lei Zhang

Background and objectives: Multimorbidity is increasingly prevalent among the middle-aged population, yet it is largely often overlooked. We aimed to explore and compare the differences in multimorbidity patterns by sex and age among middle-aged inpatients from China and the United Kingdom.

Research design and methods: We analyzed 184 133 hospitalization records from Shaanxi, China, and 180 497 from the UK Biobank for -middle-aged populations. Using network analysis, we examined multimorbidity patterns by sex, age groups (40-44, 45-49, 50-54, and 55-59 years), and countries. We also identified hub diseases in both sex-specific and sex-age-specific networks and their corresponding roles in forming multimorbidity patterns.

Results: In both China and the United Kingdom, males exhibited higher multimorbidity prevalence (China: 58.51% vs 55.33%, 1.06×; United Kingdom: 31.15% vs 29.79%, 1.05×) and greater complexity of multimorbidity patterns (China: 1179 patterns vs 990 patterns, 1.19×; United Kingdom: 438 patterns vs 377 patterns, 1.16×) than females. In sex-specific networks, males in both countries demonstrated the specificity of circulatory, genitourinary, and endocrine/nutritional/metabolic-associated multimorbidity patterns, while females demonstrated specific genitourinary and neoplasm-associated multimorbidity patterns. Hub diseases in these networks are distributed in similar disease categories. In sex-age-specific networks, dominant multimorbidity patterns and hub diseases shifted by age. In males, both countries showed stable but dominating circulatory, endocrine/nutritional/metabolic and digestive-associated multimorbidity patterns with aging. In comparison, Chinese females demonstrated an increase in nervous system-associated multimorbidity patterns and a decrease in genitourinary-associated multimorbidity patterns with ageing; British females demonstrated an increase in mental/behavioral-associated multimorbidity patterns and a stable but dominating -genitourinary-associated multimorbidity patterns.

Discussion and implications: In both China and the United Kingdom, males demonstrated more complex multimorbidity than females. With ageing, multimorbidity patterns are stable in males, while females in China and the United Kingdom each develop different and specific multimorbidity patterns. These findings may inform targeted interventions for middle-aged inpatients with multimorbidity by sex and age.

背景和目的:多病在中年人群中越来越普遍,但在很大程度上往往被忽视。我们的目的是探讨和比较中国和英国中年住院患者中按性别和年龄划分的多病模式的差异。研究设计和方法:我们分析了来自中国陕西的184 133份住院记录,以及来自英国生物样本库的180 497份中年人群住院记录。使用网络分析,我们按性别、年龄组(40-44岁、45-49岁、50-54岁和55-59岁)和国家检查了多发病模式。我们还确定了性别特异性和性别年龄特异性网络中的中心疾病及其在形成多发病模式中的相应作用。结果:中英两国男性多病患病率均高于女性(中国:58.51%对55.33%,1.06倍;英国:31.15%对29.79%,1.05倍),多病类型复杂性均高于女性(中国:1179对990,1.19倍;英国:438对377,1.16倍)。在性别特异性网络中,两国男性表现出循环、泌尿生殖系统和内分泌/营养/代谢相关的多发病模式的特异性,而女性表现出泌尿生殖系统和肿瘤相关的多发病模式的特异性。这些网络中的中心疾病分布在相似的疾病类别中。在性别年龄特异性网络中,主要的多病模式和中心疾病随年龄变化。在男性中,这两个国家都表现出稳定但占主导地位的循环、内分泌/营养/代谢和消化相关的多发病模式。相比之下,随着年龄的增长,中国女性神经系统相关的多发病模式增加,泌尿生殖系统相关的多发病模式减少;英国女性表现出精神/行为相关的多发病模式的增加,以及稳定但占主导地位的与泌尿生殖系统相关的多发病模式。讨论和启示:在中国和英国,男性比女性表现出更复杂的多病。随着年龄的增长,男性的多病模式是稳定的,而中国和英国的女性则各自发展出不同的、特定的多病模式。这些发现可能为按性别和年龄划分的多病中年住院患者提供有针对性的干预措施。
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引用次数: 0
Correction to: The Influence of Vision Impairment on the Measurement of Cognition in Older Adults in India: Findings From LASI-DAD. 修正:视力障碍对印度老年人认知测量的影响:来自LASI-DAD的发现。
IF 4.3 3区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-08-10 eCollection Date: 2025-07-01 DOI: 10.1093/geroni/igaf080

[This corrects the article DOI: 10.1093/geroni/igae071.].

[这更正了文章DOI: 10.1093/geroni/igae071.]。
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引用次数: 0
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Innovation in Aging
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