Pub Date : 2025-12-16DOI: 10.1007/s00134-025-08233-0
Ida Giorgia Iavarone, Domenico Luca Grieco, Mariangela Pellegrini, Luigi Camporota, Antoine Roquilly
{"title":"Individualized PEEP in acute brain injury: the overlooked impact of injury heterogeneity. Authors' reply","authors":"Ida Giorgia Iavarone, Domenico Luca Grieco, Mariangela Pellegrini, Luigi Camporota, Antoine Roquilly","doi":"10.1007/s00134-025-08233-0","DOIUrl":"https://doi.org/10.1007/s00134-025-08233-0","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"370 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1007/s00134-025-08254-9
Khalil Chaïbi, Didier Dreyfuss, Stephane Gaudry
{"title":"Biomarkers and the prediction of acute kidney injury and renal replacement therapy initiation: a dream within a dream","authors":"Khalil Chaïbi, Didier Dreyfuss, Stephane Gaudry","doi":"10.1007/s00134-025-08254-9","DOIUrl":"https://doi.org/10.1007/s00134-025-08254-9","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"42 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1007/s00134-025-08250-z
Orlando R. Pérez-Nieto, Ernesto Deloya-Tomas, Rafael Alfonso Reyes-Monge
{"title":"Pv-aCO2 and Pv-aCO2/Ca-vO2 in shock resuscitation: physiologically appealing, but challenging in resource-limited ICUs","authors":"Orlando R. Pérez-Nieto, Ernesto Deloya-Tomas, Rafael Alfonso Reyes-Monge","doi":"10.1007/s00134-025-08250-z","DOIUrl":"https://doi.org/10.1007/s00134-025-08250-z","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"29 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1007/s00134-025-08243-y
Mette Krag,Joanna C Dionne,Morten Hylander Møller
{"title":"Stress ulcer prophylaxis and risk of gastrointestinal bleeding in critical illness.","authors":"Mette Krag,Joanna C Dionne,Morten Hylander Møller","doi":"10.1007/s00134-025-08243-y","DOIUrl":"https://doi.org/10.1007/s00134-025-08243-y","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"4 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1007/s00134-025-08248-7
Bruno Pereira,Jean-Michel Constantin,Thomas Godet
{"title":"When statistics reach their limits: lessons learned from the analysis of the 4D study. Author's reply.","authors":"Bruno Pereira,Jean-Michel Constantin,Thomas Godet","doi":"10.1007/s00134-025-08248-7","DOIUrl":"https://doi.org/10.1007/s00134-025-08248-7","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"20 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1007/s00134-025-08240-1
Bertrand Guidet,Hans Flaatten,Hannah Wunsch
{"title":"Reduction of burnout syndrome in intensive care unit staff: mission possible?","authors":"Bertrand Guidet,Hans Flaatten,Hannah Wunsch","doi":"10.1007/s00134-025-08240-1","DOIUrl":"https://doi.org/10.1007/s00134-025-08240-1","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"23 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1007/s00134-025-08224-1
Yelena G Bodien,Katharina M Busl,Cherylee W J Chang,Jan Claassen,Nicolas Gaspard,Olivia Gosseries,Raimund Helbok,Marcello Massimini,Lionel Naccache,Virginia Newcombe,Chiara Robba,Benjamin Rohaut,Jose I Suarez,Alexis F Turgeon,Paul Vespa,Sarah Wahlster,Fabio Silvio Taccone,Giuseppe Citerio
Disorders of consciousness (DoC) represent a spectrum of clinical conditions, including coma, unresponsive wakefulness syndrome, and the minimally conscious state, which may result from structural and non-structural brain injuries due to trauma, stroke, anoxia, infections of the brain, and other causes. Clinical management of patients with DoC is especially challenging in the critical care environment, where the level of consciousness, a key factor in determining the trajectory of recovery, may be obscured by sedation, analgesia, and other confounders. The 2025 International Symposium on Intensive Care and Emergency Medicine hosted a Roundtable of 18 expert clinicians and researchers to synthesise and discuss the latest evidence on acute DoC epidemiology, diagnosis, treatment, and prognosis. Here, we summarise the output of the Roundtable in the format of a roadmap with six steps related to identifying patients with DoC, assessing for and treating confounders, establishing a diagnosis and prognosis, selecting interventions, and effectively communicating with family. This roadmap provides practical, evidence-informed guidance to help intensivists navigate diagnosis, treatment, and prognostication in patients with acute DoC. Advances in structural and functional neuroimaging, electrophysiology, and blood-based biomarkers offer promise for refined diagnostics and prognostication, though their clinical translation remains limited.
{"title":"Disorders of consciousness diagnosis, interventions, and prognostication for the intensivist: Report of the 2025 ISICEM roundtable.","authors":"Yelena G Bodien,Katharina M Busl,Cherylee W J Chang,Jan Claassen,Nicolas Gaspard,Olivia Gosseries,Raimund Helbok,Marcello Massimini,Lionel Naccache,Virginia Newcombe,Chiara Robba,Benjamin Rohaut,Jose I Suarez,Alexis F Turgeon,Paul Vespa,Sarah Wahlster,Fabio Silvio Taccone,Giuseppe Citerio","doi":"10.1007/s00134-025-08224-1","DOIUrl":"https://doi.org/10.1007/s00134-025-08224-1","url":null,"abstract":"Disorders of consciousness (DoC) represent a spectrum of clinical conditions, including coma, unresponsive wakefulness syndrome, and the minimally conscious state, which may result from structural and non-structural brain injuries due to trauma, stroke, anoxia, infections of the brain, and other causes. Clinical management of patients with DoC is especially challenging in the critical care environment, where the level of consciousness, a key factor in determining the trajectory of recovery, may be obscured by sedation, analgesia, and other confounders. The 2025 International Symposium on Intensive Care and Emergency Medicine hosted a Roundtable of 18 expert clinicians and researchers to synthesise and discuss the latest evidence on acute DoC epidemiology, diagnosis, treatment, and prognosis. Here, we summarise the output of the Roundtable in the format of a roadmap with six steps related to identifying patients with DoC, assessing for and treating confounders, establishing a diagnosis and prognosis, selecting interventions, and effectively communicating with family. This roadmap provides practical, evidence-informed guidance to help intensivists navigate diagnosis, treatment, and prognostication in patients with acute DoC. Advances in structural and functional neuroimaging, electrophysiology, and blood-based biomarkers offer promise for refined diagnostics and prognostication, though their clinical translation remains limited.","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"34 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1007/s00134-025-08172-w
Hossein Shamohammadi,Tommaso Mauri,Declan G Bates,
{"title":"Digital twins of acute hypoxemic respiratory failure and sepsis patients suggest potential benefits of bi-level high flow nasal cannula therapy.","authors":"Hossein Shamohammadi,Tommaso Mauri,Declan G Bates, ","doi":"10.1007/s00134-025-08172-w","DOIUrl":"https://doi.org/10.1007/s00134-025-08172-w","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"39 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145711023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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