Pub Date : 2026-01-26DOI: 10.1007/s00134-026-08296-7
Melanie Meersch-Dini,John A Kellum
{"title":"Biomarkers for acute kidney injury: a pragmatic approach.","authors":"Melanie Meersch-Dini,John A Kellum","doi":"10.1007/s00134-026-08296-7","DOIUrl":"https://doi.org/10.1007/s00134-026-08296-7","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"57 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1007/s00134-025-08267-4
Karen E. A. Burns, Ella Huszti, Qixuan Li, Margaret S. Herridge
Purpose
We assessed the association of sex with ICU mortality and longitudinal Functional Independence Measure (FIM) scores, Beck Depression Inventory-II (BDI-II), Impact of Event Scale-Revised (IES-R), and healthcare utilization to 1-year after hospital discharge.
Methods
Secondary analysis of medical/surgical patients in the Canadian Towards RECOVER study.
Results
Of 463 (185 females, 278 males) participants, significantly more males 45 (16.2%) versus females 20 (10.8%) died in the intensive care unit (ICU) [Hazard Ratio (HR) 1.8 (1.1, 3.1); p = 0.03]. Of 398 (165 females, 233 males) ICU survivors, 391 had FIM scores. Median FIM scores were significantly higher for male (versus female) survivors at 3-months (117 versus 106 points; p = 0.005), 6-months (119 versus 111.5 points; p = 0.005), and 12-months (121 versus 115 points; p = 0.003). Conversely, female (versus male) survivors had significantly higher BDI-II scores at 3-months [12.50 (7.0, 18.0) versus 9.0 (5.3, 14.8); p = 0.036], 6-months [11.8 (6.0, 17.8) versus 7.2 (3.0, 14.0); p = 0.009], 12-months [10.0 (4.0, 19.0) versus 11 (3.0, 26.3); p = 0.036] and higher IES-R scores at 3-months. Female survivors also experienced significantly more moderate (versus mild) [OR 6.9 (3.5, 13.7); p < 0.0001] and severe (versus moderate)[OR 40.9 (17.1, 98.2); p < 0.0001] depression. Whereas female ICU survivors had more rheumatology and nephrology specialty visits, males had more cardiology, endocrinology, surgical, and rehabilitation visits.
Conclusions
Although male ICU survivors experienced significantly higher ICU mortality, females experienced significantly lower longitudinal FIM scores and more frequent and severe depression.
{"title":"Sex, time, and disability status differences in mortality, multidimensional morbidity, and health care utilization: a secondary analysis of the Canadian RECOVER study","authors":"Karen E. A. Burns, Ella Huszti, Qixuan Li, Margaret S. Herridge","doi":"10.1007/s00134-025-08267-4","DOIUrl":"https://doi.org/10.1007/s00134-025-08267-4","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>We assessed the association of sex with ICU mortality and longitudinal Functional Independence Measure (FIM) scores, Beck Depression Inventory-II (BDI-II), Impact of Event Scale-Revised (IES-R), and healthcare utilization to 1-year after hospital discharge.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Secondary analysis of medical/surgical patients in the Canadian Towards RECOVER study.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Of 463 (185 females, 278 males) participants, significantly more males 45 (16.2%) versus females 20 (10.8%) died in the intensive care unit (ICU) [Hazard Ratio (HR) 1.8 (1.1, 3.1); p = 0.03]. Of 398 (165 females, 233 males) ICU survivors, 391 had FIM scores. Median FIM scores were significantly higher for male (versus female) survivors at 3-months (117 versus 106 points; p = 0.005), 6-months (119 versus 111.5 points; p = 0.005), and 12-months (121 versus 115 points; p = 0.003). Conversely, female (versus male) survivors had significantly higher BDI-II scores at 3-months [12.50 (7.0, 18.0) versus 9.0 (5.3, 14.8); p = 0.036], 6-months [11.8 (6.0, 17.8) versus 7.2 (3.0, 14.0); p = 0.009], 12-months [10.0 (4.0, 19.0) versus 11 (3.0, 26.3); p = 0.036] and higher IES-R scores at 3-months. Female survivors also experienced significantly more moderate (versus mild) [OR 6.9 (3.5, 13.7); p < 0.0001] and severe (versus moderate)[OR 40.9 (17.1, 98.2); p < 0.0001] depression. Whereas female ICU survivors had more rheumatology and nephrology specialty visits, males had more cardiology, endocrinology, surgical, and rehabilitation visits.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Although male ICU survivors experienced significantly higher ICU mortality, females experienced significantly lower longitudinal FIM scores and more frequent and severe depression.</p>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"9 8 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1007/s00134-025-08283-4
Wilson F Abdo
{"title":"The 11th ethical challenge: potential organ donors outside the ICU.","authors":"Wilson F Abdo","doi":"10.1007/s00134-025-08283-4","DOIUrl":"https://doi.org/10.1007/s00134-025-08283-4","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"180 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1007/s00134-025-08285-2
Saad Nseir, Jorge I. F. Salluh, Pedro Póvoa
We have identified 15 key studies to read on infection in 2025. Three studies focused on the impact of adjunctive therapies [1,2,3], while another three evaluated the role of rapid diagnostic tests (RDT) and biomarker-guided antibiotic stewardship [4,5,6]. Three articles explored strategies to optimize antimicrobial therapy [7,8,9,10] and three evaluated strategies in preventing hospital-acquired infections [11, 12]. The remaining three addressed diverse topics, including the epidemiology of acute encephalitis, consensus recommendations on recurrent ventilator-associated pneumonia (VAP) and the management of non-responding pneumonia [13,14,15].
{"title":"Update on infection: from prevention to diagnosis and management","authors":"Saad Nseir, Jorge I. F. Salluh, Pedro Póvoa","doi":"10.1007/s00134-025-08285-2","DOIUrl":"https://doi.org/10.1007/s00134-025-08285-2","url":null,"abstract":"We have identified 15 key studies to read on infection in 2025. Three studies focused on the impact of adjunctive therapies [1,2,3], while another three evaluated the role of rapid diagnostic tests (RDT) and biomarker-guided antibiotic stewardship [4,5,6]. Three articles explored strategies to optimize antimicrobial therapy [7,8,9,10] and three evaluated strategies in preventing hospital-acquired infections [11, 12]. The remaining three addressed diverse topics, including the epidemiology of acute encephalitis, consensus recommendations on recurrent ventilator-associated pneumonia (VAP) and the management of non-responding pneumonia [13,14,15].","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"49 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-22DOI: 10.1007/s00134-026-08294-9
Lui G. Forni, Alexander Zarbock
No Abstract
没有抽象的
{"title":"Early biomarker detection: fundamentally disputable?","authors":"Lui G. Forni, Alexander Zarbock","doi":"10.1007/s00134-026-08294-9","DOIUrl":"https://doi.org/10.1007/s00134-026-08294-9","url":null,"abstract":"No Abstract","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"215 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-21DOI: 10.1007/s00134-026-08297-6
Matthieu Schmidt, John F. Fraser, Fabio Silvio Taccone
Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) and veno-venous ECMO (V-V ECMO) are well-established rescue methods for cardiogenic shock and severe respiratory failure that do not respond to conventional treatment [1,2,3]. Over the past twenty years, advances in cannula design, pump and oxygenator technology, as well as the simplification of percutaneous cannulation, have significantly expanded the clinical applications of ECMO. Additionally, the development of mobile ECMO teams and standardized management protocols has further enhanced its clinical utility. In addition to traditional indications, such as fulminant myocarditis, acute myocardial infarction, or end-stage heart failure [1], perioperative V-A ECMO has become increasingly important after cardiac procedures (trans-catheter and open heart) or heart transplants, while V-V ECMO, besides acute severe respiratory failure, is more frequently used in lung transplants and complex airway surgeries. This review highlights the main perioperative applications of ECMO in surgical patients, discussing patient selection, outcomes, and complications (Fig. 1).Fig. 1Main indications of extracorporeal membrane oxygenation in patients needing surgery. A-NRP abdominal normothermic regional perfusion, ECPR Extracorporeal cardiopulmonary resuscitation, HTx heart transplantation, LTx lung transplantation, LVAD left ventricular assist device, TA-NRP thoraco-abdominal normothermic regional perfusionFull size image
{"title":"ECMO for patients needing surgery","authors":"Matthieu Schmidt, John F. Fraser, Fabio Silvio Taccone","doi":"10.1007/s00134-026-08297-6","DOIUrl":"https://doi.org/10.1007/s00134-026-08297-6","url":null,"abstract":"Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) and veno-venous ECMO (V-V ECMO) are well-established rescue methods for cardiogenic shock and severe respiratory failure that do not respond to conventional treatment [1,2,3]. Over the past twenty years, advances in cannula design, pump and oxygenator technology, as well as the simplification of percutaneous cannulation, have significantly expanded the clinical applications of ECMO. Additionally, the development of mobile ECMO teams and standardized management protocols has further enhanced its clinical utility. In addition to traditional indications, such as fulminant myocarditis, acute myocardial infarction, or end-stage heart failure [1], perioperative V-A ECMO has become increasingly important after cardiac procedures (trans-catheter and open heart) or heart transplants, while V-V ECMO, besides acute severe respiratory failure, is more frequently used in lung transplants and complex airway surgeries. This review highlights the main perioperative applications of ECMO in surgical patients, discussing patient selection, outcomes, and complications (Fig. 1).<figure><figcaption><b data-test=\"figure-caption-text\">Fig. 1</b></figcaption><source srcset=\"//media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00134-026-08297-6/MediaObjects/134_2026_8297_Fig1_HTML.png?as=webp\" type=\"image/webp\"/><img alt=\"figure 1\" aria-describedby=\"Fig1\" height=\"469\" loading=\"lazy\" src=\"//media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00134-026-08297-6/MediaObjects/134_2026_8297_Fig1_HTML.png\" width=\"685\"/></picture>Main indications of extracorporeal membrane oxygenation in patients needing surgery. <i>A-NRP</i> abdominal normothermic regional perfusion, <i>ECPR</i> Extracorporeal cardiopulmonary resuscitation, <i>HTx</i> heart transplantation, <i>LTx</i> lung transplantation, <i>LVAD</i> left ventricular assist device, <i>TA-NRP</i> thoraco-abdominal normothermic regional perfusion<span>Full size image</span><svg aria-hidden=\"true\" focusable=\"false\" height=\"16\" role=\"img\" width=\"16\"><use xlink:href=\"#icon-eds-i-chevron-right-small\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"></use></svg></figure>","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"37 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1007/s00134-025-08279-0
Gerd Klinkmann,Thiago Reis,Claudio Ronco,
{"title":"Correspondence regarding the article by Hüser et al. on \"Critical care management of the patient with pharmaceutical poisoning\".","authors":"Gerd Klinkmann,Thiago Reis,Claudio Ronco, ","doi":"10.1007/s00134-025-08279-0","DOIUrl":"https://doi.org/10.1007/s00134-025-08279-0","url":null,"abstract":"","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"31 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-20DOI: 10.1007/s00134-026-08301-z
Maximilian S. Schaefer, Theresa Tenge, Emmanuel Futier
More than 230 million patients undergo general anesthesia with mechanical ventilation (MV) every year worldwide [1]. Millions develop postoperative pulmonary complications (PPC), substantially driving perioperative mortality. Optimum invasive ventilation for patients undergoing major surgery has been identified a top research priority in perioperative medicine [2]. Compared to the intensive care unit (ICU), patients in the operating room (OR) experience shorter periods of exposure and often present with healthier lungs and more favorable respiratory system mechanics. Ventilation practices, therefore, still differ between the OR and critical care setting [3]. This article highlights key principles and the relevance of intraoperative ventilator settings in the light of insights on intraoperative MV.
{"title":"How to set the ventilator during surgery? Key principles to guide intraoperative mechanical ventilation","authors":"Maximilian S. Schaefer, Theresa Tenge, Emmanuel Futier","doi":"10.1007/s00134-026-08301-z","DOIUrl":"https://doi.org/10.1007/s00134-026-08301-z","url":null,"abstract":"More than 230 million patients undergo general anesthesia with mechanical ventilation (MV) every year worldwide [1]. Millions develop postoperative pulmonary complications (PPC), substantially driving perioperative mortality. Optimum invasive ventilation for patients undergoing major surgery has been identified a top research priority in perioperative medicine [2]. Compared to the intensive care unit (ICU), patients in the operating room (OR) experience shorter periods of exposure and often present with healthier lungs and more favorable respiratory system mechanics. Ventilation practices, therefore, still differ between the OR and critical care setting [3]. This article highlights key principles and the relevance of intraoperative ventilator settings in the light of insights on intraoperative MV.","PeriodicalId":13665,"journal":{"name":"Intensive Care Medicine","volume":"32 1","pages":""},"PeriodicalIF":38.9,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Main indications of extracorporeal membrane oxygenation in patients needing surgery. A-NRP abdominal normothermic regional perfusion, ECPR Extracorporeal cardiopulmonary resuscitation, HTx heart transplantation, LTx lung transplantation, LVAD left ventricular assist device, TA-NRP thoraco-abdominal normothermic regional perfusionFull size image
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