Desmond C Winter, Ville Sallinen, Jonothan J Earnshaw
{"title":"BJS and BJS Open correspondence to move to the BJS Academy.","authors":"Desmond C Winter, Ville Sallinen, Jonothan J Earnshaw","doi":"10.1093/bjs/znae147","DOIUrl":"https://doi.org/10.1093/bjs/znae147","url":null,"abstract":"","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on: Influence of cardiometabolic medications on abdominal aortic aneurysm growth in the UK Aneurysm Growth Study: metformin and angiotensin-converting enzyme inhibitors associated with slower aneurysm growth.","authors":"Jiaan Lu, Guanhu Yang, Hao Chi","doi":"10.1093/bjs/znae154","DOIUrl":"https://doi.org/10.1093/bjs/znae154","url":null,"abstract":"","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Author response to: Comment on: Peak wall rupture index is associated with risk of rupture of abdominal aortic aneurysms, independent of size and sex.","authors":"Antti Siika, Moritz Lindquist Liljeqvist, Joy Roy","doi":"10.1093/bjs/znae174","DOIUrl":"10.1093/bjs/znae174","url":null,"abstract":"","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11256994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141722730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hany Zayed, Athanasios Saratzis, Paul Moxey, S Tawqeer Rashid, Peter Mezes, Athanasios Diamantopoulos, Symeon Lechareas, Joo-Young Chun, Michael Twigg, Narayanan Thulasidasan, Kaji Sritharan
{"title":"Transcatheter arterialization of the deep veins: 1-year outcomes of PROMISE-UK study.","authors":"Hany Zayed, Athanasios Saratzis, Paul Moxey, S Tawqeer Rashid, Peter Mezes, Athanasios Diamantopoulos, Symeon Lechareas, Joo-Young Chun, Michael Twigg, Narayanan Thulasidasan, Kaji Sritharan","doi":"10.1093/bjs/znae188","DOIUrl":"10.1093/bjs/znae188","url":null,"abstract":"","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Global access to technologies to support safe and effective inguinal hernia surgery: prospective, international cohort study.","authors":"","doi":"10.1093/bjs/znae164","DOIUrl":"10.1093/bjs/znae164","url":null,"abstract":"","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11235323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141578361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancing targeted axillary dissection in node-positive breast cancer: insights from pooled analyses and systematic review.","authors":"Umar Wazir, Kefah Mokbel","doi":"10.1093/bjs/znae141","DOIUrl":"10.1093/bjs/znae141","url":null,"abstract":"","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum to: Predictive value of early lactate (<6 h) during normothermic machine perfusion and outcome after liver transplantation: results from a multicentre study.","authors":"","doi":"10.1093/bjs/znae182","DOIUrl":"10.1093/bjs/znae182","url":null,"abstract":"","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11248711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141618728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"High-dose glucocorticoids: improving outcomes of emergency laparotomy by reducing inflammation.","authors":"Dileep N Lobo","doi":"10.1093/bjs/znae153","DOIUrl":"10.1093/bjs/znae153","url":null,"abstract":"","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141726527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georgios Antonios Margonis, Jaeyun Jane Wang, Thomas Boerner, Roberto Moretto, Stefan Buettner, Nikolaos Andreatos, Johan Gagnière, Doris Wagner, Inger Marie Løes, Francesca Bergamo, Filippo Pietrantonio, Mario Scartozzi, Andrea Spallanzani, Bruno Vincenzi, Efstathios Antoniou, Emmanouil Pikoulis, Andrea Sartore-Bianchi, Georgios Stasinos, Kazunari Sasaki, Timothy M Pawlik, Armando Orlandi, Nicoletta Pella, Fabian Fitschek, Klaus Kaczirek, Aurélien Dupré, Ioannis Pozios, Katharina Beyer, Peter Kornprat, Federico N Aucejo, Richard Burkhart, Matthew J Weiss, Per Eystein Lønning, George Poultsides, Chiara Cremolini, Martin E Kreis, Michael D'Angelica
Background: To date, only two studies have compared the outcomes of patients with liver-limited BRAF V600E-mutated colorectal liver metastases (CRLMs) managed with resection versus systemic therapy alone, and these have reported contradictory findings.
Methods: In this observational, international, multicentre study, patients with liver-limited BRAF V600E-mutated CRLMs treated with resection or systemic therapy alone were identified from institutional databases. Patterns of recurrence/progression and overall survival were compared using multivariable analyses of the entire cohort and a propensity score-matched cohort.
Results: Of 170 patients included, 119 underwent hepatectomy and 51 received systemic treatment. Surgically treated patients had a more favourable pattern of recurrence with most recurrences limited to a single site, whereas diffuse progression was more common among patients who received systemic treatment (19 versus 44%; P = 0.002). Surgically treated patients had longer median overall survival (35 versus 20 months; P < 0.001). Hepatectomy was independently associated with better OS than systemic treatment alone (HR 0.37, 95% c.i. 0.21 to 0.65). In the propensity score-matched cohort, surgically treated patients had longer median overall survival (28 versus 20 months; P < 0.001); hepatectomy was independently associated with better overall survival (HR 0.47, 0.25 to 0.88).
Conclusion: BRAF V600E mutation should not be considered a contraindication to surgery for patients with resectable, liver-only CRLMs.
{"title":"Hepatectomy versus systemic therapy for liver-limited BRAF V600E-mutated colorectal liver metastases: multicentre retrospective study.","authors":"Georgios Antonios Margonis, Jaeyun Jane Wang, Thomas Boerner, Roberto Moretto, Stefan Buettner, Nikolaos Andreatos, Johan Gagnière, Doris Wagner, Inger Marie Løes, Francesca Bergamo, Filippo Pietrantonio, Mario Scartozzi, Andrea Spallanzani, Bruno Vincenzi, Efstathios Antoniou, Emmanouil Pikoulis, Andrea Sartore-Bianchi, Georgios Stasinos, Kazunari Sasaki, Timothy M Pawlik, Armando Orlandi, Nicoletta Pella, Fabian Fitschek, Klaus Kaczirek, Aurélien Dupré, Ioannis Pozios, Katharina Beyer, Peter Kornprat, Federico N Aucejo, Richard Burkhart, Matthew J Weiss, Per Eystein Lønning, George Poultsides, Chiara Cremolini, Martin E Kreis, Michael D'Angelica","doi":"10.1093/bjs/znae176","DOIUrl":"10.1093/bjs/znae176","url":null,"abstract":"<p><strong>Background: </strong>To date, only two studies have compared the outcomes of patients with liver-limited BRAF V600E-mutated colorectal liver metastases (CRLMs) managed with resection versus systemic therapy alone, and these have reported contradictory findings.</p><p><strong>Methods: </strong>In this observational, international, multicentre study, patients with liver-limited BRAF V600E-mutated CRLMs treated with resection or systemic therapy alone were identified from institutional databases. Patterns of recurrence/progression and overall survival were compared using multivariable analyses of the entire cohort and a propensity score-matched cohort.</p><p><strong>Results: </strong>Of 170 patients included, 119 underwent hepatectomy and 51 received systemic treatment. Surgically treated patients had a more favourable pattern of recurrence with most recurrences limited to a single site, whereas diffuse progression was more common among patients who received systemic treatment (19 versus 44%; P = 0.002). Surgically treated patients had longer median overall survival (35 versus 20 months; P < 0.001). Hepatectomy was independently associated with better OS than systemic treatment alone (HR 0.37, 95% c.i. 0.21 to 0.65). In the propensity score-matched cohort, surgically treated patients had longer median overall survival (28 versus 20 months; P < 0.001); hepatectomy was independently associated with better overall survival (HR 0.47, 0.25 to 0.88).</p><p><strong>Conclusion: </strong>BRAF V600E mutation should not be considered a contraindication to surgery for patients with resectable, liver-only CRLMs.</p>","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141755928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sabine R de Wild, Linetta B Koppert, Thiemo J A van Nijnatten, Loes F S Kooreman, Marie-Jeanne T F D Vrancken Peeters, Marjolein L Smidt, Janine M Simons
{"title":"Author response: advancing targeted axillary dissection in node-positive breast cancer: insights from pooled analyses and systematic review.","authors":"Sabine R de Wild, Linetta B Koppert, Thiemo J A van Nijnatten, Loes F S Kooreman, Marie-Jeanne T F D Vrancken Peeters, Marjolein L Smidt, Janine M Simons","doi":"10.1093/bjs/znae142","DOIUrl":"10.1093/bjs/znae142","url":null,"abstract":"","PeriodicalId":136,"journal":{"name":"British Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11217811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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