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Multidisciplinary management for primary uterine osteosarcoma, including gene panel testing: case report and literature review. 原发性子宫骨肉瘤的多学科治疗,包括基因组检测:病例报告和文献综述。
IF 0.7 Q4 ONCOLOGY Pub Date : 2023-05-09 eCollection Date: 2023-10-01 DOI: 10.1007/s13691-023-00613-x
Takako Kusanishi, Naotake Tanaka, Mizue Itoi, Miwa Ijiri, Keiko Ebisawa, Kiyomi Suzuka, Youko Hagiwara, Tukasa Yonemoto, Akinobu Araki, Makiko Itami

Primary osteosarcoma of the uterus (uOS) is rare, and its standard treatment has not yet been established. Herein, we present the case of a 50-year-old woman with uOS who demonstrated an improved prognosis after multiple surgeries to the metastatic sites. After the initial diagnosis of uOS, the patient showed recurrence and distant metastasis and hence expected to exhibit a poor prognosis. The patient underwent multiple surgical resections of the metastatic as well as primary tumors, which enabled the patient to survive for 24 months after the initial surgery. Considering that the median survival time of patients with uOS is approximately 6 months, the survival rate of our patient is noteworthy. Based on our observations, it is suggested that the resection of the primary and metastatic tumors might contribute to the extension of the survival period of the patient with chemo-resistant uOS.

原发性子宫骨肉瘤(uOS)是罕见的,其标准治疗方法尚未确定。在此,我们介绍了一例50岁的uOS妇女,她在对转移部位进行多次手术后,预后有所改善。在最初诊断为uOS后,患者出现复发和远处转移,因此预计预后不佳。患者接受了多次转移性和原发性肿瘤的手术切除,这使患者能够在初次手术后存活24个月。考虑到uOS患者的中位生存时间约为6个月,我们患者的生存率值得注意。根据我们的观察,原发性和转移性肿瘤的切除可能有助于延长化疗耐药uOS患者的生存期。
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引用次数: 0
Characteristic imaging findings in a patient with chronic expanding hematoma on the floor of the mouth. 一名口腔底部慢性扩张性血肿患者的特征性影像学表现。
IF 0.7 Q4 ONCOLOGY Pub Date : 2023-05-04 eCollection Date: 2023-07-01 DOI: 10.1007/s13691-023-00610-0
Yusuke Miyasaka, Takashi Hiyama, Hirofumi Kuno, Takeshi Shinozaki, Shingo Sakashita, Tatsushi Kobayashi

Chronic expanding hematoma (CEH) is defined as chronic hematoma enlargement for more than 1 month. Although CEH rarely occurs on the floor of the mouth, the need to distinguish these cases from malignant disease is critical, given the need for potentially extensive resection in patients with malignancy. We report a case of CEH on the floor of the mouth, which required differentiation from malignant tumor. A 42-year-old woman was referred to our hospital for a submucosal mass on the right floor of the mouth, with a diagnosis of class 3 on aspiration cytology. Computed tomography revealed a submucosal mass with peripheral calcification on the floor of the mouth, which exhibited a hypointense rim on T2-weighted imaging and gradual nodular-like enhancement in the periphery on contrast-enhanced magnetic resonance imaging. Enucleation was performed to reach a definitive diagnosis, and CEH was confirmed pathologically. Well-defined morphology, presence of calcification, a hypointense rim on T2-weighted imaging, and weak peripheral nodular-like enhancement may be characteristic findings of CEH on the floor of the mouth. Accordingly, these imaging features may aid in differentiating CEH from low-grade malignancies and in determining the optimal management strategy.

慢性扩大性血肿(CEH)是指持续1个月以上的慢性血肿扩大。尽管CEH很少发生在口腔底部,但考虑到恶性肿瘤患者可能需要进行广泛切除,区分这些病例与恶性疾病的必要性至关重要。我们报告了一例口腔底部的CEH,它需要从恶性肿瘤中分化出来。一名42岁的女性因口腔右底黏膜下肿块被转诊至我院,抽吸细胞学诊断为3级。计算机断层扫描显示,口腔底部有一个粘膜下层肿块,伴有周围钙化,T2加权成像显示边缘低强度,增强磁共振成像显示周围逐渐结节状增强。进行了去核以达到明确的诊断,并通过病理证实了CEH。明确的形态、钙化的存在、T2加权成像上的低强度边缘和微弱的周围结节状增强可能是口底CEH的特征性表现。因此,这些成像特征可能有助于区分CEH和低度恶性肿瘤,并确定最佳治疗策略。
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引用次数: 0
A surgical resection of hepatic granuloma mimicking intrahepatic cholangiocarcinoma: a case report. 一例模拟肝内胆管癌的肝肉芽肿的外科切除术。
IF 0.7 Q4 ONCOLOGY Pub Date : 2023-04-26 eCollection Date: 2023-07-01 DOI: 10.1007/s13691-023-00607-9
Kazuki Omachi, Katsunori Imai, Yosuke Nakao, Hiro Nakamura, Takayoshi Kaida, Yuta Shiraishi, Rumi Itoyama, Hidetoshi Nitta, Hiromitsu Hayashi, Tsuguharu Asato, Yoshiki Mikami, Hideo Baba

Hepatic granuloma is relatively rare, and benign tumor of the liver. Herein, we report an unusual case of hepatic granuloma mimicking intrahepatic cholangiocarcinoma (ICC). An 82-year-old woman with a history of viral hepatitis B was admitted for investigation of liver mass in the left lobe. Dynamic computed tomography revealed a mostly hypo-enhancing main tumor with a peripheral ring enhancement, and positron emission tomography demonstrated localized an abnormal accumulation of fludeoxyglucose. Considering the possibility of malignant disease, extended left hepatectomy was performed. The resected tumor was macroscopically a periductal infiltrating nodular type, 4.5 × 3.6 cm in diameter. The pathological findings showed that granuloma and coagulative necrosis were present, and diagnosis of hepatic granuloma was confirmed. Pathological studies demonstrated that periodic acid-Schiff stain, Grocott-Gomori stain and Ziehl-Neelsen stain were all negative in the lesion.

肝脏肉芽肿是比较罕见的,而且是肝脏的良性肿瘤。在此,我们报告一个不寻常的肝肉芽肿模仿肝内胆管癌(ICC)的病例。一位82岁有乙型病毒性肝炎病史的女性因左叶肝脏肿块入院接受检查。动态计算机断层扫描显示主要肿瘤低增强,周围环增强,正电子发射断层扫描显示局部氟脱氧葡萄糖异常积聚。考虑到恶性疾病的可能性,进行了扩大左肝切除术。切除的肿瘤肉眼可见为导管周围浸润结节型,4.5 × 直径3.6厘米。病理表现为肉芽肿和凝固性坏死,诊断为肝肉芽肿。病理学研究表明,周期性酸性Schiff染色、Grocott-Gomori染色和Ziehl-Neelsen染色均为阴性。
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引用次数: 0
An unusual case of a tibial metastasis as the first clinical presentation of a serous papillary carcinoma of the ovarian epithelial type of the testis. 一例罕见的胫骨转移病例,首次临床表现为睾丸卵巢上皮型浆液性乳头状癌。
IF 0.7 Q4 ONCOLOGY Pub Date : 2023-04-13 eCollection Date: 2023-07-01 DOI: 10.1007/s13691-023-00608-8
Maria Napoletano, Margherita Bartocci, Carlo Perna, Emanuele Vocino, Antonella Segoni

Among testicular neoplasms, ovarian-type epithelial tumors constitute an exceedingly rare group, with only a few cases reported in the literature. We describe the case of an 82-year-old man, presented with complaints of right leg pain and difficulty walking, who was found to have a large right tibial metastasis of unknown primary origin. Whole body CT scan did not reveal any cranial, thoracic or abdominal tumor masses, but it showed abnormal para-aortic lymph nodes and right spermatic cord swelling. An extemporary ultrasound examination found a right testicular mass. The patient underwent radical orchiectomy, and the diagnosis of a serous papillary carcinoma of the ovarian epithelial type of the testis was made. To the best of our knowledge, this is the first case in the literature of isolated bone metastasis from ovarian-type epithelial tumor of testis.

在睾丸肿瘤中,卵巢型上皮肿瘤是极为罕见的一组,文献中仅报道了少数病例。我们描述了一个82岁的男性病例,他主诉右腿疼痛和行走困难,被发现有一个主要来源不明的右胫骨大转移瘤。全身CT扫描未发现任何颅骨、胸部或腹部肿瘤肿块,但显示主动脉旁淋巴结异常和右侧精索肿胀。临时超声检查发现右侧睾丸肿块。患者接受了根治性睾丸切除术,诊断为睾丸卵巢上皮型浆液性乳头状癌。据我们所知,这是文献中第一例睾丸卵巢型上皮肿瘤的孤立性骨转移。
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引用次数: 0
A long-term survival case of bladder cancer with distant metastases: abscopal effect of brain metastases after stereotactic radiotherapy with immune checkpoint blockade therapy to lung metastases. 一例癌症远处转移的长期生存病例:立体定向放射治疗与免疫检查点阻断治疗肺转移后脑转移的潜逃效应。
IF 0.7 Q4 ONCOLOGY Pub Date : 2023-04-03 eCollection Date: 2023-07-01 DOI: 10.1007/s13691-023-00606-w
Sawa Kono, Yaichiro Hashimoto, Yurie Shirai, Yasuhiro Kunihiro, Kenta Ohmatsu, Miki Kawanishi, Shigehiko Kuribayashi, Kumiko Karasawa

Brain metastases from bladder cancer are rare, with a poor prognosis. There is no standard treatment for bladder cancer with brain metastases; thus, palliative therapy is generally provided. We report a case of abscopal effect in a single brain metastasis from bladder cancer in a patient treated with focal stereotactic radiotherapy (total dose = 52 Gy, administered in eight fractions) with immune checkpoint blockade therapy for lung metastases, who achieved long-term disease-free survival (> 4 years). To our knowledge, although there have been some reports on abscopal effects in bladder cancer, there are no previous reports on patients with brain metastases. To date, the brain metastasis, which showed an "abscopal effect," continues to maintain complete regression.

癌症的脑转移是罕见的,预后很差。癌症脑转移没有标准的治疗方法;因此,通常提供姑息治疗。我们报告了一例接受局灶性立体定向放射治疗(总剂量 = 52 Gy,分八个部分给药)与免疫检查点阻断治疗肺转移,获得长期无病生存(> 4年)。据我们所知,尽管已经有一些关于膀胱癌症潜逃效应的报道,但之前没有关于脑转移患者的报道。到目前为止,显示出“潜逃效应”的脑转移继续保持完全消退。
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引用次数: 0
Proton beam therapy for cervical lymph node metastasis in an octogenarian with melanoma of unknown primary: a case report. 质子束治疗八旬不明原发黑色素瘤颈部淋巴结转移一例。
IF 0.7 Q4 ONCOLOGY Pub Date : 2023-04-01 DOI: 10.1007/s13691-023-00597-8
Masatoshi Nakamura, Kayoko Ohnishi, Fumihiko Uchida, Takashi Saito, Yuri Kitagawa, Ryota Matsuoka, Toru Yanagawa, Hideyuki Sakurai

An 80-year-old man with an approximately 3-cm mass in the right submandibular region presented to our institution. Magnetic resonance imaging revealed enlarged lymph nodes (LNs) in the right neck, and fluorine-18-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) indicated positive FDG accumulation in the right neck LNs only. Excisional biopsy was performed for suspected malignant lymphoma, and the biopsy revealed melanoma. Close examination of the skin, nasal cavity, oral pharyngeal and laryngeal cavities, and gastrointestinal tract were performed. No primary tumor was detected by these examinations, and the patient was diagnosed with cervical LN metastasis from melanoma of unknown primary of clinical stage T0N3bM0 stage IIIC. The patient refused cervical neck dissection because of his age and comorbidity of Alzheimer's disease and instead opted for proton beam therapy (PBT) at a total dose of 69 Gy (relative biological effectiveness) in 23 fractions. He did not receive any systemic therapy. The enlarged LNs shrunk slowly, and FDG PET/CT at 1 year after PBT showed that the right submandibular LN had shrunk from 27 to 7 mm in length, and there was no significant FDG accumulation. At 6 years and 4 months after PBT, the patient is alive without any recurrence.

一位80岁的男性,右下颌下区域有一个大约3厘米的肿块。磁共振成像显示右侧颈部淋巴结肿大,氟-18-2-脱氧-d -葡萄糖(FDG)正电子发射断层扫描(PET)/计算机断层扫描(CT)显示右侧颈部淋巴结有FDG阳性积聚。疑似恶性淋巴瘤行切除活检,活检显示黑色素瘤。对皮肤、鼻腔、口腔咽喉腔及胃肠道进行了严密检查。上述检查均未发现原发肿瘤,诊断为原发不明黑色素瘤宫颈癌淋巴结转移,临床分期T0N3bM0分期IIIC。由于患者的年龄和阿尔茨海默病的合并症,患者拒绝了颈椎切除术,而是选择了质子束治疗(PBT),总剂量为69 Gy(相对生物有效性),分23份。他没有接受任何全身治疗。增大的LN收缩缓慢,PBT后1年FDG PET/CT显示右侧下颌下LN长度由27 mm缩小至7 mm,未见明显FDG堆积。PBT术后6年零4个月,患者存活,无复发。
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引用次数: 0
Peritoneal and pulmonary tuberculosis following intravesical administration of Bacillus Calmette-Guérin for bladder cancer. 膀胱内注射Calmette-Guérin杆菌治疗膀胱癌症后的腹膜和肺结核。
IF 0.7 Q4 ONCOLOGY Pub Date : 2023-04-01 eCollection Date: 2023-07-01 DOI: 10.1007/s13691-023-00602-0
Riku Uematsu, Jun Teishima, Hiroyuki Sakata, Yoshie Mita, Takahiko Yoshii, Yuki Tashiro, Akihisa Yao, Ichiro Nakamura

We report a rare case of peritoneal and pulmonary tuberculosis after intravesical instillation of Bacillus Calmette-Guérin (BCG). A 76-year-old man diagnosed as high-grade urothelial carcinoma (UC) with carcinoma in situ (CIS) was treated with intravesical BCG instillation and transurethral resection of bladder tumor (TUR-BT). Three months later, TUR-BT for recurrent tumors and multiple site biopsy of bladder mucosa were performed. During TUR-BT, near perforation in the posterior wall was observed, and was disappeared after observation with urethral catheterization for 1 week. Two weeks later, he was admitted with a complaint of abdominal distention, and a computed tomography (CT) showed ascites. One week later, CT showed pleural effusion and worsening of ascites. Drainage of pleural effusion and ascites puncture was performed, and elevated adenosine deaminase (ADA) and lymphocytes count were subsequently found. In laparoscopic examination, numerous white nodules were observed in the peritoneum and omentum, and Langhans giant cells were pathologically identified in biopsy specimens. Mycobacterium culture confirmed Mycobacterium tuberculosis complex. The patient was then diagnosed with pulmonary and peritoneal tuberculosis. Anti-tuberculous agents consisting of isoniazid (INH), rifampicin (RFP), and ethambutol (EB) were administered. Six months later, a CT scan showed no evidence of pleural effusion or ascites. There has been no recurrence of either urothelial cancer or tuberculosis during follow-up for 2 years.

我们报告了一个罕见的腹膜和肺结核病例后膀胱内滴注卡介苗(BCG)。一名76岁男性被诊断为高级别尿路上皮癌(UC)伴原位癌(CIS),接受膀胱内BCG滴注和经尿道膀胱肿瘤切除术(TUR-BT)治疗。三个月后,对复发性肿瘤进行TUR-BT检查,并对膀胱粘膜进行多部位活检。TUR-BT期间,观察到后壁近穿孔,经导尿1周后消失。两周后,他因腹胀入院,计算机断层扫描(CT)显示腹水。一周后,CT显示胸腔积液,腹水加重。进行胸腔积液引流和腹水穿刺,随后发现腺苷脱氨酶(ADA)和淋巴细胞计数升高。在腹腔镜检查中,腹膜和网膜中观察到许多白色结节,活检标本中病理鉴定为郎汉斯巨细胞。分枝杆菌培养证实结核分枝杆菌复合体。患者随后被诊断为肺结核和腹膜结核。使用由异烟肼(INH)、利福平(RFP)和乙胺丁醇(EB)组成的抗结核药物。六个月后,CT扫描显示没有胸腔积液或腹水的迹象。随访2年,无尿路上皮癌症或肺结核复发。
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引用次数: 0
Symptom palliation with QUAD Shot radiation therapy to penile metastasis derived from descending colon cancer: a case report. QUAD Shot放射治疗癌症下行期阴茎转移的症状缓解:一例报告。
IF 0.7 Q4 ONCOLOGY Pub Date : 2023-03-30 eCollection Date: 2023-07-01 DOI: 10.1007/s13691-023-00604-y
Akira Yamamoto, Hideharu Ieki, Mai Shimamura, Masahiro Tsujiura, Takeshi Yokoe, Naoko Sanuki, Eiki Ojima, Keiichi Uchida, Yasuhiko Mohri

A 54-year-old man was diagnosed with descending colon cancer with metastases in the liver, para-aortic lymph nodes, and penis, and chemotherapy was introduced after construction of a colostomy. The patient reported only mild penile pain at the time of diagnosis; however, the pain gradually worsened and interfered with his daily life. Opioids did not provide sufficient analgesia, and the patient developed dysuria and priapism. Through construction of a cystostomy, palliative radiotherapy with QUAD Shot regimen (14 Gy in 4 fractions twice-daily on 2 days repeated every 4 weeks) to the penile metastasis was started for pain relief and tumor shrinkage. The radiation rapidly improved the penile symptoms, enabling opioid reduction and cystostomy removal. The patient remained pain-free and able to urinate on his own until his death. Metastatic penile tumors are rare, especially those derived from colon cancer. Penile metastases occur mainly in the late stages of cancer and may impair the patient's quality of life. In such cases, palliative radiotherapy, especially with QUAD Shot regimen, is useful with short treatment time, durable symptom control, and little adverse effect, maintaining quality of life.

一名54岁的男子被诊断为降结肠癌症,肝脏、皮质旁淋巴结和阴茎有转移,在造结肠后进行了化疗。患者在诊断时仅报告轻微的阴茎疼痛;然而,疼痛逐渐加重,影响了他的日常生活。阿片类药物不能提供足够的镇痛作用,患者出现排尿困难和阴茎异常勃起。通过建造膀胱造瘘术,开始对阴茎转移进行QUAD Shot方案的姑息性放射治疗(14 Gy,4次,每天两次,每4周重复2天),以缓解疼痛和缩小肿瘤。辐射迅速改善了阴茎症状,使阿片类药物减少和膀胱造口术得以切除。病人一直没有疼痛,可以自己小便,直到去世。转移性阴茎肿瘤是罕见的,特别是那些来源于结肠癌癌症。阴茎转移主要发生在癌症晚期,可能损害患者的生活质量。在这种情况下,姑息性放射治疗,特别是QUAD Shot方案,治疗时间短,症状控制持久,不良反应小,可保持生活质量。
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引用次数: 0
Unusual presentation of adult granulosa cell tumor. A case report and review of the literature. 成人颗粒细胞肿瘤的异常表现。病例报告和文献综述。
IF 0.7 Q4 ONCOLOGY Pub Date : 2023-03-30 eCollection Date: 2023-07-01 DOI: 10.1007/s13691-023-00603-z
K Oqbani, M Mouhoub, S Abbaoui

Extraovarian adult granulosa cell tumor is a very uncommon neoplasm, which probably arises from the ectopic gonadal tissue along the embryonic root of the genital ridge. We report a new and rare case of an extraovarian adult granulosa cell tumor occurring in a 66-year-old woman who was presented with severe abdominal pain focused on the left iliac fossa. The immunohistopathology confirmed the diagnosis of a paratubal adult granulosa cell tumor. This paper illustrates the histogenetic origin of granulosa cell tumor, its clinicopathological and immunohistochemical features.

卵巢外成人颗粒细胞瘤是一种非常罕见的肿瘤,可能起源于生殖嵴胚胎根的异位性腺组织。我们报告了一例罕见的卵巢外成人颗粒细胞肿瘤,发生在一名66岁的女性身上,她表现出严重的腹痛,集中在左髂窝。免疫组织病理学证实诊断为一个管旁成人颗粒细胞瘤。本文阐述颗粒细胞瘤的组织遗传学起源、临床病理和免疫组织化学特征。
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引用次数: 0
Anti-Mi-2 antibody-positive lung cancer-associated polymyositis. 抗Mi-2抗体阳性肺癌相关多发性肌炎。
IF 0.7 Q4 ONCOLOGY Pub Date : 2023-03-14 eCollection Date: 2023-07-01 DOI: 10.1007/s13691-023-00601-1
Masafumi Shimoda, Yoshiaki Tanaka, Atsuo Taniguchi, Kozo Morimoto, Kozo Yoshimori, Ken Ohta

After a 75-year-old man was diagnosed with lung cancer, proximal weakness and myalgia in the bilateral lower extremities developed, and the creatinine kinase (CK) level was elevated. The anti-Mi-2 antibody test was positive, muscle T2-weighted/fat-suppressed magnetic resonance imaging showed high intensity, and there were no skin lesions. Therefore, he was diagnosed with lung cancer-associated polymyositis (PM). The lung tumour shrank after chemotherapy, accompanied by gradual improvement of his PM-derived symptoms and CK level. Although positive anti-Mi-2 antibody tests rarely indicate PM and cancer, examining myositis-specific autoantibodies, including anti-Mi-2, should be considered if the CK level increases after a cancer diagnosis.

一名75岁男子被诊断为癌症后,双侧下肢出现近端无力和肌痛,肌酸酐激酶(CK)水平升高。抗Mi-2抗体检测呈阳性,肌肉T2加权/脂肪抑制磁共振成像显示高强度,没有皮肤损伤。因此,他被诊断为肺癌相关多发性肌炎(PM)。化疗后肺部肿瘤缩小,伴随着PM衍生症状和CK水平的逐渐改善。尽管阳性的抗Mi-2抗体测试很少表明PM和癌症,但如果癌症诊断后CK水平升高,则应考虑检查包括抗Mi-2在内的肌炎组织特异性自身抗体。
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引用次数: 0
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International Cancer Conference Journal
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