Pub Date : 2022-01-01DOI: 10.4103/ijabmr.ijabmr_354_21
Mayank Gupta, P. Tiwari
In forensic medicine, firearm-related fatalities are regular. The range and velocity of the bullet, the characteristics of the wounds, and the probability of recovery are vital components of forensic analyses. While examining gunshot wounds to the skull, focus on the critical difference between bullet entry and exit points and the distance between the muzzle and the bullet entrance is vital. Determining bullet injury in cases of extreme decay has been a difficult challenge. The police send a corpse in the later stages of decomposition for re-postmortem examination, with a history of severe blunt force injuries to the head in our case report. Following the reconstruction of the skull, it is determined that some regions are bone deficient. A bullet entry wound is present on the left side's upper border of the defect, formed like an arc (representing the upper 1/3rd of a circle), and a corresponding exit wound was discovered on the right side's lower border of the defect, shaped like an arc (representing the lower 1/3rd of a circle). The bullet passed left to right backward and downward. It is noteworthy that in cases of advanced decomposition, where identifying the characteristics of a bullet wound is nearly impossible, fully skeletonizing the body and reconstructing it will provide critical hints to establishing the cause of death.
{"title":"An Autopsy Case of the Decomposed Body with Kronlein's Shot and the Importance of Skull Reconstruction","authors":"Mayank Gupta, P. Tiwari","doi":"10.4103/ijabmr.ijabmr_354_21","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_354_21","url":null,"abstract":"In forensic medicine, firearm-related fatalities are regular. The range and velocity of the bullet, the characteristics of the wounds, and the probability of recovery are vital components of forensic analyses. While examining gunshot wounds to the skull, focus on the critical difference between bullet entry and exit points and the distance between the muzzle and the bullet entrance is vital. Determining bullet injury in cases of extreme decay has been a difficult challenge. The police send a corpse in the later stages of decomposition for re-postmortem examination, with a history of severe blunt force injuries to the head in our case report. Following the reconstruction of the skull, it is determined that some regions are bone deficient. A bullet entry wound is present on the left side's upper border of the defect, formed like an arc (representing the upper 1/3rd of a circle), and a corresponding exit wound was discovered on the right side's lower border of the defect, shaped like an arc (representing the lower 1/3rd of a circle). The bullet passed left to right backward and downward. It is noteworthy that in cases of advanced decomposition, where identifying the characteristics of a bullet wound is nearly impossible, fully skeletonizing the body and reconstructing it will provide critical hints to establishing the cause of death.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"12 1","pages":"47 - 50"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43571760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4103/ijabmr.ijabmr_644_21
N. Rege
{"title":"“Principles of Assessment in Medical Education”: A Review of Revised Second Edition","authors":"N. Rege","doi":"10.4103/ijabmr.ijabmr_644_21","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_644_21","url":null,"abstract":"","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"12 1","pages":"67 - 69"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47636668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4103/ijabmr.ijabmr_553_21
C. Kakkar, Kamini Gupta, Kunal Jain, V. Narang, Aminder Singh, K. Saggar, N. Bansal, D. Cioni, E. Neri
Background: Magnetic resonance imaging (MRI) has been shown to be an accurate imaging technique for the preoperative assessment of local staging of endometrial cancer and for evaluating the depth of myometrial invasion. Materials and Methods: This was a single-center retrospective study performed on patients with histopathologically proven endometrial carcinoma who underwent an MRI examination of the pelvis between October 2017 and May 2020. Results: In the present analysis, mean apparent diffusion coefficient (ADC) values for each histologic grade were 0.72 ± 0.13 × 10−3 mm2/s (G1), 0.76 ± 0.17 × 10−3 mm2/s (G2), and 0.74 ± 0.12 × 10−3 mm2/s (G3), respectively, showing no significant correlation between ADC values and tumor grade (P = 0.73). Overall, ADC minimum was significant in differentiating grades of endometrial carcinoma (P = 0.02) with the ability to differentiate Grade I and II lesions (P = 0.01). A mean tumor volume of 25.2 cc could differentiate low-grade tumors (Grade I and Grade II) from high-grade tumors (Grade III) with a sensitivity and specificity of 88% and specificity of 89%. The tumor volume/uterine volume ratio (TV/UV) differentiates high-grade tumors from low-grade tumors (P < 0.001), however, no significant difference in the ratio was observed among Grade I and II lesions (P = 0.48). The area under the curve of tumor volume was 0.875 (95% confidence interval 0.0–1.00) (P = 0.001), indicating that tumor volume was an effective tool for distinguishing high-grade and low-grade endometrioid adenocarcinomas. The corresponding sensitivity and specificity were 88.0% and 89.0%, respectively. Conclusion: Preoperative noninvasive radiological assessment for tumor volume, TV/ UV or tumor volume/uterine volume is important surrogate markers for preoperative prognostication of endometrial carcinoma.
{"title":"Diagnostic Accuracy of Calculated Tumor Volumes and Apparent Diffusion Coefficient Values in Predicting Endometrial Cancer Grade","authors":"C. Kakkar, Kamini Gupta, Kunal Jain, V. Narang, Aminder Singh, K. Saggar, N. Bansal, D. Cioni, E. Neri","doi":"10.4103/ijabmr.ijabmr_553_21","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_553_21","url":null,"abstract":"Background: Magnetic resonance imaging (MRI) has been shown to be an accurate imaging technique for the preoperative assessment of local staging of endometrial cancer and for evaluating the depth of myometrial invasion. Materials and Methods: This was a single-center retrospective study performed on patients with histopathologically proven endometrial carcinoma who underwent an MRI examination of the pelvis between October 2017 and May 2020. Results: In the present analysis, mean apparent diffusion coefficient (ADC) values for each histologic grade were 0.72 ± 0.13 × 10−3 mm2/s (G1), 0.76 ± 0.17 × 10−3 mm2/s (G2), and 0.74 ± 0.12 × 10−3 mm2/s (G3), respectively, showing no significant correlation between ADC values and tumor grade (P = 0.73). Overall, ADC minimum was significant in differentiating grades of endometrial carcinoma (P = 0.02) with the ability to differentiate Grade I and II lesions (P = 0.01). A mean tumor volume of 25.2 cc could differentiate low-grade tumors (Grade I and Grade II) from high-grade tumors (Grade III) with a sensitivity and specificity of 88% and specificity of 89%. The tumor volume/uterine volume ratio (TV/UV) differentiates high-grade tumors from low-grade tumors (P < 0.001), however, no significant difference in the ratio was observed among Grade I and II lesions (P = 0.48). The area under the curve of tumor volume was 0.875 (95% confidence interval 0.0–1.00) (P = 0.001), indicating that tumor volume was an effective tool for distinguishing high-grade and low-grade endometrioid adenocarcinomas. The corresponding sensitivity and specificity were 88.0% and 89.0%, respectively. Conclusion: Preoperative noninvasive radiological assessment for tumor volume, TV/ UV or tumor volume/uterine volume is important surrogate markers for preoperative prognostication of endometrial carcinoma.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"12 1","pages":"37 - 42"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45007472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4103/ijabmr.ijabmr_301_21
D. Šečić, A. Turohan, E. Begić, D. Rebić, E. Pepić, Z. Begić, A. Iglica, N. Begić, Azra Metović, J. Mušanović
Introduction: Serum creatinine is not enough sensitive marker for the evaluation of glomerular filtration rate (GFR). Cockcroft-Gault (CG) formula is often used to assess GFR, but it is necessary to correct original one for body surface area (BSA), adipositas, and the creatinine tubular secretion. The values of the estimated creatinine clearance and GFR are considered to Poggio reference ones according to biological parameters (age and gender). The aim of the study was to determine the difference in renal function estimation between serum creatinine and corrected CG equation according to the Poggio reference values in the arterial hypertension patients. Materials and Methods: The research included 124 patients of both gender with arterial hypertension, excluding ones with the already verified chronic kidney disease. We estimated creatinine clearance and GFR by CG method corrected for the BSA, body mass index (BMI), and the creatinine tubular secretion according to Poggio reference values. Results: There was no significant difference in both age and gender groups among patients with physiological and pathological values of the renal function determined by the serum creatinine and estimated creatinine clearance by CG equation corrected for BMI, BSA. In both age and gender groups there was significant difference among subjects with physiological and pathological values of the renal function determined by serum creatinine and estimated GFR by CG method corrected for BMI, BSA, and creatinine tubular secretion. Conclusion: There is the most striking difference in the assessment of renal function between serum creatinine and estimated GFR by CG method with three corrections (BSA, BMI, the creatinine tubular secretion). Estimated GFR by CG method with three corrections can help in the early diagnosis of renal dysfunction and optimal treatment in patients with arterial hypertension.
{"title":"Serum Creatinine versus Corrected Cockcroft-Gault Equation According to Poggio Reference Values in Patients with Arterial Hypertension","authors":"D. Šečić, A. Turohan, E. Begić, D. Rebić, E. Pepić, Z. Begić, A. Iglica, N. Begić, Azra Metović, J. Mušanović","doi":"10.4103/ijabmr.ijabmr_301_21","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_301_21","url":null,"abstract":"Introduction: Serum creatinine is not enough sensitive marker for the evaluation of glomerular filtration rate (GFR). Cockcroft-Gault (CG) formula is often used to assess GFR, but it is necessary to correct original one for body surface area (BSA), adipositas, and the creatinine tubular secretion. The values of the estimated creatinine clearance and GFR are considered to Poggio reference ones according to biological parameters (age and gender). The aim of the study was to determine the difference in renal function estimation between serum creatinine and corrected CG equation according to the Poggio reference values in the arterial hypertension patients. Materials and Methods: The research included 124 patients of both gender with arterial hypertension, excluding ones with the already verified chronic kidney disease. We estimated creatinine clearance and GFR by CG method corrected for the BSA, body mass index (BMI), and the creatinine tubular secretion according to Poggio reference values. Results: There was no significant difference in both age and gender groups among patients with physiological and pathological values of the renal function determined by the serum creatinine and estimated creatinine clearance by CG equation corrected for BMI, BSA. In both age and gender groups there was significant difference among subjects with physiological and pathological values of the renal function determined by serum creatinine and estimated GFR by CG method corrected for BMI, BSA, and creatinine tubular secretion. Conclusion: There is the most striking difference in the assessment of renal function between serum creatinine and estimated GFR by CG method with three corrections (BSA, BMI, the creatinine tubular secretion). Estimated GFR by CG method with three corrections can help in the early diagnosis of renal dysfunction and optimal treatment in patients with arterial hypertension.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"12 1","pages":"9 - 13"},"PeriodicalIF":1.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46237717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-01DOI: 10.4103/ijabmr.ijabmr_628_21
R. Mahajan
{"title":"Practical Manual of Pharmacology for Medical Students: Book Review","authors":"R. Mahajan","doi":"10.4103/ijabmr.ijabmr_628_21","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_628_21","url":null,"abstract":"","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"11 1","pages":"280 - 281"},"PeriodicalIF":1.1,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43305852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-01DOI: 10.4103/ijabmr.ijabmr_172_21
M. Joshi
{"title":"Principles of Medical Education: A Review of Book's Fifth Edition","authors":"M. Joshi","doi":"10.4103/ijabmr.ijabmr_172_21","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_172_21","url":null,"abstract":"","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"11 1","pages":"125 - 127"},"PeriodicalIF":1.1,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45890800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-10-01DOI: 10.4103/ijabmr.IJABMR_604_20
A. Supe
{"title":"Humanities in Medical Education","authors":"A. Supe","doi":"10.4103/ijabmr.IJABMR_604_20","DOIUrl":"https://doi.org/10.4103/ijabmr.IJABMR_604_20","url":null,"abstract":"","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"10 1","pages":"296 - 297"},"PeriodicalIF":1.1,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42604203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum","authors":"","doi":"10.1159/000505248","DOIUrl":"https://doi.org/10.1159/000505248","url":null,"abstract":"","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"2 1","pages":"62 - 62"},"PeriodicalIF":1.1,"publicationDate":"2020-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000505248","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45052320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-01DOI: 10.4103/ijabmr.IJABMR_119_19
Aabha Suryavanshi, Ruchi Kalra
Introduction: Term prelabor rupture of membranes and preterm premature rupture of membranes (PROM), both pose significant risk to the mother and the fetus. Early identification of sepsis is essential as the mother has risk of chorioamnionitis and neonate is at the risk of early-onset sepsis. Aim: To evaluate the diagnostic value of positive maternal C-reactive protein (CRP) in association with maternal clinical chorioamnionitis and early-onset neonatal sepsis (EONS) in PROM deliveries after 28 weeks of gestation. Methodology: The study was conducted at People's College of Medical Science and Research Centre, Bhopal, from June 1, 2017, to May 31, 2018. Maternal serum CRP test was correlated to the signs of maternal chorioamnionitis and signs of EONS within 72 h of life. Results: The maternal CRP test was compared to clinical signs of chorioamnionitis. Sensitivity of CRP for diagnosing maternal chorioamnionitis was 48% (95% confidence interval [CI] −35.99–61.12), specificity was 81 (95% CI 71.55%–88.98%), and odds ratio of maternal chorioamnionitis was 4.1176 (95% CI 1.99–8.51) with P < 0.0001. Sensitivity of positive maternal CRP in diagnosing EONS was 56.67% (95% CI 43.24%–69.41%), specificity was 84.78% (95% CI 75.79%–91.42%), and odds ratio of neonatal sepsis in maternal CRP positive was 7.28 (95%CI 3.39–15.64) with P < 0.0001. Conclusion: Our study suggests that in PROM deliveries, if maternal CRP test is positive, then it indicates early delivery and neonate screening for EONS.
{"title":"Study of Association of C-Reactive Protein with Maternal Chorioamnionitis and Early-Onset Neonatal Sepsis in Premature Rupture of Membranes Deliveries: A Diagnostic Dilemma","authors":"Aabha Suryavanshi, Ruchi Kalra","doi":"10.4103/ijabmr.IJABMR_119_19","DOIUrl":"https://doi.org/10.4103/ijabmr.IJABMR_119_19","url":null,"abstract":"Introduction: Term prelabor rupture of membranes and preterm premature rupture of membranes (PROM), both pose significant risk to the mother and the fetus. Early identification of sepsis is essential as the mother has risk of chorioamnionitis and neonate is at the risk of early-onset sepsis. Aim: To evaluate the diagnostic value of positive maternal C-reactive protein (CRP) in association with maternal clinical chorioamnionitis and early-onset neonatal sepsis (EONS) in PROM deliveries after 28 weeks of gestation. Methodology: The study was conducted at People's College of Medical Science and Research Centre, Bhopal, from June 1, 2017, to May 31, 2018. Maternal serum CRP test was correlated to the signs of maternal chorioamnionitis and signs of EONS within 72 h of life. Results: The maternal CRP test was compared to clinical signs of chorioamnionitis. Sensitivity of CRP for diagnosing maternal chorioamnionitis was 48% (95% confidence interval [CI] −35.99–61.12), specificity was 81 (95% CI 71.55%–88.98%), and odds ratio of maternal chorioamnionitis was 4.1176 (95% CI 1.99–8.51) with P < 0.0001. Sensitivity of positive maternal CRP in diagnosing EONS was 56.67% (95% CI 43.24%–69.41%), specificity was 84.78% (95% CI 75.79%–91.42%), and odds ratio of neonatal sepsis in maternal CRP positive was 7.28 (95%CI 3.39–15.64) with P < 0.0001. Conclusion: Our study suggests that in PROM deliveries, if maternal CRP test is positive, then it indicates early delivery and neonate screening for EONS.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"9 1","pages":"236 - 240"},"PeriodicalIF":1.1,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43416804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-10-01DOI: 10.4103/ijabmr.IJABMR_221_18
D. Uppala, A. Sabu, NV Ratna Mouli, N. Tejaswini, V. Rohit, G. Nishitha
Introduction: Oral cancer ranks third among all cancers in the Indian population with approximately 45% of call cancer cases in India being diagnosed as oral cancer, among which 20%–50% of the cases are observed to be associated with human papillomavirus (HPV) infection. Aim: This study aims to detect and evaluate the presence of p16 in oropharyngeal squamous cell carcinoma (OPSCC) patients using immunohistochemistry (IHC). Materials and Methods: This study was based on samples collected from 21 patients with primary OPSCC who were diagnosed and treated during the period of December 2017–March 2018. Inclusion criteria were complete clinicopathologic data, adequate clinical follow-up, and availability of sufficient paraffin-embedded tumor material. HPV immunoreactivity was further investigated by means of IHC using p16 as a marker. Results: IHC results revealed p16 positivity in six OPSCC cases. There was no statistically significant association of the p16 positivity of HPV with the age, gender, or site. Conclusion: Our results suggest that IHC-based detection of p16 provides a suboptimal prognostic information if not combined with detection of HPV DNA. Although p16 expression and HPV DNA infection are correlated with HPV-associated OPSCCs, neither of the tests alone is the optimal method for HPV status detection.
{"title":"Human Papillomavirus Detection in Oropharyngeal Squamous Cell Carcinoma Using p16 Immunohistochemistry","authors":"D. Uppala, A. Sabu, NV Ratna Mouli, N. Tejaswini, V. Rohit, G. Nishitha","doi":"10.4103/ijabmr.IJABMR_221_18","DOIUrl":"https://doi.org/10.4103/ijabmr.IJABMR_221_18","url":null,"abstract":"Introduction: Oral cancer ranks third among all cancers in the Indian population with approximately 45% of call cancer cases in India being diagnosed as oral cancer, among which 20%–50% of the cases are observed to be associated with human papillomavirus (HPV) infection. Aim: This study aims to detect and evaluate the presence of p16 in oropharyngeal squamous cell carcinoma (OPSCC) patients using immunohistochemistry (IHC). Materials and Methods: This study was based on samples collected from 21 patients with primary OPSCC who were diagnosed and treated during the period of December 2017–March 2018. Inclusion criteria were complete clinicopathologic data, adequate clinical follow-up, and availability of sufficient paraffin-embedded tumor material. HPV immunoreactivity was further investigated by means of IHC using p16 as a marker. Results: IHC results revealed p16 positivity in six OPSCC cases. There was no statistically significant association of the p16 positivity of HPV with the age, gender, or site. Conclusion: Our results suggest that IHC-based detection of p16 provides a suboptimal prognostic information if not combined with detection of HPV DNA. Although p16 expression and HPV DNA infection are correlated with HPV-associated OPSCCs, neither of the tests alone is the optimal method for HPV status detection.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":"9 1","pages":"212 - 216"},"PeriodicalIF":1.1,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44488111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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