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Salivary 1,5-Anhydroglucitol and its Correlation with Postprandial Hyperglycemia: Development and Validation of a Novel Assay. 唾液1,5-脱水葡萄糖醇及其与餐后高血糖的相关性:一种新检测方法的开发和验证。
IF 1.1 Pub Date : 2023-01-01 Epub Date: 2023-03-27 DOI: 10.4103/ijabmr.ijabmr_378_22
Priyadarshini Subramaniam Kedarnath, S Sathasiva Subramanian, Emmanuel Bhaskar, Mohan Kasi, Vinod Pillai, Saravanan Subramanian, Venkat Manohar

Background: Saliva has the potential to be used as a noninvasive sample for testing hyperglycemia in diabetes mellitus. Serum 1,5-anhydroglucitol (1,5-AG) decreases with an increase in blood sugar >180 mg/dl. We hypothesized that salivary 1,5-AG can be used to identify blood sugar higher than 180 mg/dl using a novel biochemical method.

Aim: This study aimed to develop a novel biochemical method for serum and salivary assessment of 1,5-AG and assess its correlation with postprandial blood sugar (PPBS) >180 mg/dl.

Methodology: The study comprised 45 controls (healthy individuals) and 45 cases (type 2 diabetic patients with PPBS >180 mg/dl). Blood and salivary samples were collected according to the study protocol. A new method was developed for the quantification of 1,5-AG in serum and saliva using liquid chromatography-mass spectrometry.

Results: The value of serum (mean -22.19 μg/ml and median -22.12 μg/ml) and salivary (mean -0.124 μg/ml and median -0.088 μg/ml) 1,5-AG was higher in healthy individuals compared to corresponding serum (mean -3.89 μg/ml and median -2.52 μg/ml) and salivary (mean -0.025 μg/ml and median - 0.025 μg/ml) levels in diabetics with PPBS >180 mg/dl. In diabetics, a significant negative correlation was noticed with PPBS levels and 1,5-AG levels in serum and saliva. Salivary 1,5-AG level <0.054 μg/ml had an 86.4% sensitivity and 87.2% specificity in predicting a blood sugar value >180 mg/dl.

Conclusion: The results of our study suggest that the short-term glycemic marker 1,5-AG can be detected in saliva and can be useful as an adjunct marker in monitoring of glycemic status in diabetic patients.

背景:唾液具有作为检测糖尿病高血糖的非侵入性样本的潜力。血清1,5-羟基葡萄糖醇(1,5-AG)随血糖升高而降低>180 mg/dl。我们假设唾液中的1,5-AG可以通过一种新的生化方法用于识别高于180mg/dl的血糖。目的:本研究旨在开发一种新的血清和唾液中1,5-AG的生化评估方法,并评估其与餐后血糖(PPBS)>180 mg/dl的相关性。方法:该研究包括45名对照(健康个体)和45名病例(PPBS>180 mg/dl的2型糖尿病患者)。根据研究方案采集血液和唾液样本。建立了一种液相色谱-质谱法测定血清和唾液中1,5-AG的新方法。结果:健康人的血清(平均-22.19μg/ml,中位数-22.12μg/ml)和唾液(平均-0.124μg/ml,中值-0.088μg/ml)1,5-AG水平高于PPBS>180 mg/dl糖尿病患者的相应血清(平均-3.89μg/ml和中值-2.52μg/ml)及唾液(平均-0.025μg/ml,中位-0.025μg/ml)水平。在糖尿病患者中,血清和唾液中的PPBS水平和1,5-AG水平呈显著负相关。唾液中1,5-AG水平为180 mg/dl。结论:我们的研究结果表明,短期血糖标志物1,5-AG可以在唾液中检测到,并可作为糖尿病患者血糖状态监测的辅助标志物。
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引用次数: 0
Rifampicin Allergy Leading to Acute Renal Shutdown. 利福平过敏导致急性肾功能衰竭。
IF 1.1 Pub Date : 2023-01-01 Epub Date: 2023-03-27 DOI: 10.4103/ijabmr.ijabmr_198_22
Ranjith Jeyasekharan, Ninoo George

Rifampicin is a widely used drug to treat tuberculosis and leprosy. Its toxicity is predominantly hepatic and immunoallergic in character. While hepatic toxicity is dose-related, the immunoallergic effects are unpredictable and usually associated with intermittent therapy. These immunoallergic effects may be minor (a cutaneous, gastrointestinal, or influenza-like syndrome) or major (hemolytic anemia, shock, or acute renal failure). Herein, we report a case of rifampicin allergy in a patient who was on intermittent once monthly rifampicin therapy for neuritic leprosy and was on his 4th month of treatment. Rifampicin exposure led to sudden shock and acute renal failure, which eventually required hemodialysis support. The patient made a complete recovery over the subsequent days and his renal function returned to normal over the next 3 weeks. He continues his multidrug therapy of leprosy without rifampicin.

利福平是一种广泛用于治疗结核病和麻风病的药物。其毒性主要为肝脏和免疫过敏性。虽然肝毒性与剂量有关,但免疫过敏反应是不可预测的,通常与间歇性治疗有关。这些免疫过敏反应可能是轻微的(皮肤、胃肠道或流感样综合征)或严重的(溶血性贫血、休克或急性肾衰竭)。在此,我们报告了一名患者的利福平过敏病例,该患者因神经炎性麻风病接受间歇性利福平治疗,每月一次,治疗时间为4个月。利福平暴露导致突然休克和急性肾衰竭,最终需要血液透析支持。患者在随后的几天内完全康复,肾功能在接下来的3周内恢复正常。他继续在没有利福平的情况下进行麻风病的多药治疗。
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引用次数: 0
Effectiveness of Parental Preparedness Package among Couples Conceived with Artificial Reproductive Techniques. 人工生殖技术构想的夫妇父母准备包的有效性。
IF 1.1 Pub Date : 2023-01-01 Epub Date: 2023-03-27 DOI: 10.4103/ijabmr.ijabmr_447_22
Nidhi Arora, Triza Jiwan, Sunil Kumar Juneja, Pooja Tandon

Introduction: The problem of infertility is experienced as a crisis or major life stressor with potentially serious negative effects on the couple's relationship and preparation toward the parenthood. According to Sharlip et al., it has been estimated that about 15% of couple would have trouble in conception, and at present, 48.5 million couples experience infertility globally. To decrease the stress among parents to be and to promote healthy parenting for bringing out healthy parent-child relationships, an intervention of Parent Education Program was planned and executed. A study was conducted with the aim to assess the effectiveness of parental preparedness package (PPP) on physical health among couple conceived with artificial reproductive techniques (ART).

Materials and methods: The study was conducted to evaluate the effectiveness of PPP in fifty couples conceived with ART at Dayanand Medical College and Hospital, Ludhiana. Quantitative approach was used to collect the data of couples by doing pre- and postinterventional assessment of physical health of couple using the Structured Physical Health Assessment Scale. Analysis was done with the help of descriptive and inferential statistics.

Results: The study revealed that mean score of physical health of couple (both husband and wife) increased significantly after the intervention which infers the effectiveness of PPP (P = 0.001).

Conclusion: Our study concludes that PPP should be incorporated in the antenatal care protocol in all couples who conceive using ART.

引言:不孕不育是一种危机或主要的生活压力源,可能会对夫妻关系和为人父母的准备产生严重的负面影响。根据Sharlip等人的数据,据估计,大约15%的夫妇会在受孕方面遇到困难,目前,全球有4850万对夫妇经历不孕不育。为了减轻准父母的压力,促进健康的育儿,建立健康的亲子关系,计划并实施了家长教育计划的干预措施。本研究旨在评估父母准备包(PPP)对使用人工生殖技术(ART)受孕的夫妇的身体健康的有效性。材料和方法:本研究在卢迪亚纳Dayanand医学院和医院对50对使用ART受孕的夫妇进行了PPP的有效性评估。采用定量方法,采用结构化身体健康评估量表对夫妇的身体健康进行干预前和干预后评估,收集夫妇的数据。分析是在描述性和推断统计学的帮助下进行的。结果:研究表明,干预后夫妻双方的身体健康平均得分显著提高,从而推断PPP的有效性(P=0.001)。结论:我们的研究得出结论,在所有使用ART怀孕的夫妇中,PPP应纳入产前护理方案。
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引用次数: 0
Book Review: Toolbox for Assessment of Clinical Competence 书评:评估临床能力的工具箱
Pub Date : 2023-01-01 DOI: 10.4103/ijabmr.ijabmr_400_23
K. Ramnarayan
Editors: Tejinder Singh and Rajiv Mahajan Publisher: Unistar Books Pvt Ltd., Chandigarh Year of publication: 2023 Price: Rs. 250 Number of pages: 124 Tagging objectives to assessment has become the hallmark of a robust curriculum; yet, it has been a daunting task to accomplish this pragmatically. In 1996, van der Vleuten so trenchantly said “assessment drives learning in at least four ways: its content, format, timing, and any subsequent feedback given to the examinee.” Over a quarter century later we, in medical education, are grappling with the knotty task of meaningfully aligning the assessment to the objectives. Scriven’s definition of assessment in 1991 envisaged a systematic, objective determination of merit, worth, or value to distinguish between the worthy and the unworthy. However, this definition had ignored formative assessment altogether. Moreover, the emphasis of today’s assessment has shifted toward integration to assess the ability of a student to integrate knowledge, skills, attitudes, and values into a clinical situation. It is in the background of this scenario that the manual “Toolbox for Assessment of Clinical Competence” edited by Tejinder Singh and Rajiv Mahajan becomes contextually relevant and timely. The authors have, in this repertoire, not only captured formative and summative assessments with all its nuances but have also linked the assessment tools to the various levels of Miller’s pyramid. The thoroughness with which the editors have organized the content is testimony to their expertise and ingenuity. Classifying assessment tools under the categories of “knows and knows how,” “shows,” and “does” is a refreshing approach to understanding and implementing the various assessment strategies. This manual is a primer in the assessment of clinical competence while serving as a ready reckoner with the choicest compendium of invaluable references for more in-depth exploration. A medical educator who is serious and sincere about using the power of assessment to decide the learning of competencies will derive a wealth of ideas from this treasury of assessment. Every medical education unit in a medical college as well as every practitioner of health professions education will be enriched and empowered by this sourcebook, which could serve as a guidepost to conceive and practice various approaches to measurement of competence while conceding that not everything that matters can or need to be measured! “Students can, with difficulty, escape from the effects of poor teaching, but they cannot (if they want to graduate) escape the effects of poor assessment” said David Boud. Therefore, it is incumbent on all of us, as educators, to strive to make assessment in health sciences meet its laudable goals, which this book has so masterfully accomplished.
编辑:Tejinder Singh和Rajiv Mahajan出版社:Unistar Books Pvt Ltd.,昌迪加尔出版年份:2023价格:250卢比页数:124标记目标的评估已成为一个强大的课程的标志;然而,务实地实现这一目标是一项艰巨的任务。1996年,van der Vleuten非常尖锐地说:“评估至少在四个方面推动学习:它的内容、形式、时间以及随后给考生的任何反馈。”四分之一个世纪过去了,在医学教育中,我们正在努力解决使评估与目标有意义地保持一致的棘手任务。Scriven在1991年对评估的定义设想了一个系统的、客观的优点、价值或价值的确定,以区分值得和不值得。然而,这个定义完全忽略了形成性评价。此外,今天评估的重点已经转向整合,以评估学生将知识、技能、态度和价值观整合到临床情境中的能力。正是在这种情况的背景下,由Tejinder Singh和Rajiv Mahajan编辑的手册“临床能力评估工具箱”变得具有上下文相关性和时代性。作者们,在这个节目中,不仅抓住了形成性和总结性评估的所有细微差别,而且还将评估工具与米勒金字塔的各个层次联系起来。编辑组织内容的彻底性证明了他们的专业知识和独创性。将评估工具分类为“知道和知道如何”、“显示”和“做”是理解和实现各种评估策略的一种令人耳目一新的方法。本手册是在临床能力的评估入门,同时作为一个现成的计算与选择的宝贵的参考汇编更深入的探索。一位认真而真诚地利用评估的力量来决定能力学习的医学教育者将从评估宝库中获得丰富的思想。每一个医学院校的医学教育单位以及每一个卫生专业教育的从业者都将通过这本资料手册得到丰富和授权,它可以作为一个指南,在承认并非所有重要的事情都可以或需要被衡量的同时,构思和实践各种衡量能力的方法!David Boud说:“学生们可以很困难地摆脱糟糕教学的影响,但他们无法(如果他们想毕业的话)摆脱糟糕评估的影响。”因此,作为教育工作者,我们所有人都有责任努力使健康科学评估达到其值得称赞的目标,这本书已经如此巧妙地完成了这一目标。
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引用次数: 0
Development of a High Penetration Safe Irrigant from Withania somnifera 高渗透安全灌溉水的研制
Pub Date : 2023-01-01 DOI: 10.4103/ijabmr.ijabmr_89_23
Manreet Parhar, Parveen Bansal
Background: Herbal medicine is regaining a strong position in health care by virtue of better safety and minimal toxicity as compared to conventional chemotherapies. It is making a place in dental care in the form of various toothpastes, lotions, and mouthwashes. It has been analyzed that very few discrete herbal irrigants have an action comparable to that of sodium hypochlorite. No data about any study on penetration depth and penetration area for herbal-based irrigants used in root canal treatment are available. Aim: The aim of this study was to assess the efficacy of Withania somnifera extracts by assessing its penetration depth and area inside dentinal tubules using a confocal laser scanning microscope. Materials and Methods: Freshly extracted 25 maxillary central incisors were divided into three groups: Group 1: W. somnifera ; Group 2: sodium hypochlorite; and Group 3: distilled water. Results: W. somnifera showed better results with respect to penetration depth and area inside the dentinal tubules thansodium hypochlorite. Conclusion: From the study, it can be concluded that W. somnifera extract-based irrigant may be used as an alternative to sodium hypochlorite-based irrigant. It also shows that more herbal drugs need such types of screening and incorporation in dental practice to reduce the potential side effects of the conventional drugs used in daily practice.
背景:与传统化疗相比,草药具有更好的安全性和最小的毒性,在医疗保健中重新获得了强有力的地位。它以各种牙膏、乳液和漱口水的形式在牙科保健领域占有一席之地。据分析,很少有草药冲洗剂具有与次氯酸钠相当的作用。目前尚无草药灌洗剂在根管治疗中渗透深度和渗透面积的研究数据。目的:利用激光共聚焦扫描显微镜观察苦参提取物在牙本质小管内的渗透深度和面积,以评价苦参提取物的临床疗效。材料与方法:新鲜拔除的上颌中切牙25颗,分为3组:第一组:梦菜;第二组:次氯酸钠;第三组:蒸馏水。结果:在牙本质小管内的渗透深度和面积方面,三叶草的效果优于次氯酸钠。结论:从本研究中可以看出,以苦参提取物为基础的冲洗剂可以替代次氯酸钠为基础的冲洗剂。它还表明,更多的草药需要在牙科实践中进行这种类型的筛选和结合,以减少日常实践中使用的传统药物的潜在副作用。
{"title":"Development of a High Penetration Safe Irrigant from Withania somnifera","authors":"Manreet Parhar, Parveen Bansal","doi":"10.4103/ijabmr.ijabmr_89_23","DOIUrl":"https://doi.org/10.4103/ijabmr.ijabmr_89_23","url":null,"abstract":"Background: Herbal medicine is regaining a strong position in health care by virtue of better safety and minimal toxicity as compared to conventional chemotherapies. It is making a place in dental care in the form of various toothpastes, lotions, and mouthwashes. It has been analyzed that very few discrete herbal irrigants have an action comparable to that of sodium hypochlorite. No data about any study on penetration depth and penetration area for herbal-based irrigants used in root canal treatment are available. Aim: The aim of this study was to assess the efficacy of Withania somnifera extracts by assessing its penetration depth and area inside dentinal tubules using a confocal laser scanning microscope. Materials and Methods: Freshly extracted 25 maxillary central incisors were divided into three groups: Group 1: W. somnifera ; Group 2: sodium hypochlorite; and Group 3: distilled water. Results: W. somnifera showed better results with respect to penetration depth and area inside the dentinal tubules thansodium hypochlorite. Conclusion: From the study, it can be concluded that W. somnifera extract-based irrigant may be used as an alternative to sodium hypochlorite-based irrigant. It also shows that more herbal drugs need such types of screening and incorporation in dental practice to reduce the potential side effects of the conventional drugs used in daily practice.","PeriodicalId":13727,"journal":{"name":"International Journal of Applied and Basic Medical Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135844765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID and Kidney: The Struggle So Far. 新冠肺炎与肾脏:迄今为止的斗争。
IF 1.1 Pub Date : 2023-01-01 Epub Date: 2023-03-27 DOI: 10.4103/ijabmr.ijabmr_571_22
Simran Kaur, Sudhir Mehta
Severe acute respiratory syndrome coronavirus disease‐2 pandemic (SARS‐COVID‐19) posed a global health challenge, including many special concerns for patients with kidney diseases. As the pandemic began, the nephrology fraternity worldwide geared up for rapid reconfiguration of services to address the unprecedented increased demand for acute renal replacement therapy (RRT) in COVID critical care units. Strategies were devised to address the safety concerns of patients of incenter maintenance hemodialysis due to their inability to adhere to lockdown, social distancing, and home isolation norms given the compulsion to attend treatment. Concerns also existed about feasibility and rationale of kidney transplantation in pandemic scenario, as it might increase the risk of postoperative death in new recipients. Despite the rapid development of vaccines and identification of effective treatments for severe disease, many of these challenges persisted with the continuing emergence of novel SARS‐CoV‐2 variants. Numerous studies were published over the course of time addressing the above concerns. However, the ability to draw meaningful conclusions from these studies had been another challenge owing to various limitations such as different methodologies and lack of standardization in treatment. Now with COVID in hiatus, it is time to assimilate the lessons learned from the published literature in the past 2 years.
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引用次数: 0
The Impact of Team Triage Method on Emergency Department Performance Indexes: A quasi-interventional study 团队分诊方法对急诊科绩效指标的影响:一项准介入研究
Pub Date : 2023-01-01 DOI: 10.4103/ijabmr.ijabmr_614_22
Zhila Yousefi, Hossein Feizollahzadeh, Kavous Shahsavarinia, Esmail Khodadadi
Introduction: One of the effective methods of patient triage in the emergency department (ED) is the use of team triage, including physicians and nurses. Considering that there is no conclusive evidence about the effectiveness of team triage, this study aimed to investigate the effect of the team triage method on ED performance indexes. Methods: The present study is a quasi-interventional study in which 200 patients were referred to the ED in the hospitals of Tabriz in 2020. Participants were randomly assigned to two groups (team triage and conventional triage) and were evaluated. Data were collected by a three-part questionnaire including the participants’ demographic characteristics, the five-level triage form, and Press-Ganey satisfaction questionnaire were used. Data were analyzed by SPSS.22 statistical software. Results: The results showed that the mean score of waiting time for the first physician visit in team triage was statistically significantly lower than the conventional triage ( P = 0.001). Furthermore, the mean score of waiting time for receiving the first treatment in team triage was statistically significantly lower than the conventional triage ( P = 0.001). Finally, the mean score of patients’ satisfaction in team and conventional triage was statistically significantly higher in team triage ( P = 0.001). Conclusion: The study findings revealed that the team triage method, in comparison to conventional triage, decrease the waiting time for receiving the first service and length of stay, but leads to more patient’s satisfaction. Therefore, to improve the performance indicators of the ED, it is recommended that hospital managers use the team triage method.
简介:在急诊科(ED)患者分诊的有效方法之一是使用团队分诊,包括医生和护士。鉴于团队分诊的有效性尚无确凿证据,本研究旨在探讨团队分诊方法对急诊科绩效指标的影响。方法:本研究是一项准介入研究,对大不里士市各医院2020年转介到急诊科的200例患者进行研究。参与者被随机分为两组(团队分诊和常规分诊)并进行评估。数据收集采用三部分调查问卷,包括参与者的人口统计学特征,五级分流表和Press-Ganey满意度问卷。数据采用SPSS.22统计软件进行分析。结果:小组分诊的首次就诊等待时间平均得分低于常规分诊(P = 0.001)。此外,团队分诊的首次治疗等待时间平均得分低于常规分诊(P = 0.001)。最后,团队分诊和常规分诊的满意度平均得分均高于团队分诊,差异有统计学意义(P = 0.001)。结论:与传统分诊方法相比,团队分诊方法减少了首次服务的等待时间和住院时间,但提高了患者的满意度。因此,为了提高急诊科的绩效指标,建议医院管理者采用团队分诊方法。
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引用次数: 0
Ectopic Tooth with Odontogenic Keratocyst in Myasthenia Gravis: A Rare Coexistence 重症肌无力患者异位牙伴牙源性角化囊肿:罕见共存
Pub Date : 2023-01-01 DOI: 10.4103/ijabmr.ijabmr_4_23
A. Christy Winnifred, T. Jones Raja Devathambi, R. Thanigainathan, Preethi Rajkumar
Ectopic tooth in nondentate areas is uncommon. Odontogenic keratocyst arising from impacted tooth in the inferior border of orbit is very rare. This article reports the case of a 22-year-old female with odontogenic keratocyst arising from an impacted left maxillary third molar in the inferior border of the orbit causing symptoms of chronic sinusitis. The patient also had myasthenia gravis which confounded the diagnosis. The cyst was surgically enucleated along with the tooth which relieved the symptoms of the patient.
异位牙在无齿区域是不常见的。摘要牙源性角化囊肿发生于眶下缘的阻生牙是非常罕见的。本文报告一位22岁女性,因左颌第三磨牙眶下缘阻生而产生牙源性角化囊肿,引起慢性鼻窦炎的症状。患者也有重症肌无力,这混淆了诊断。囊肿随牙齿一起手术切除,减轻了患者的症状。
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引用次数: 0
Posterior Gastric Perforation with an Opening in Transverse Mesocolon: A Rare Case Report 胃后穿孔伴横结肠系膜开口1例罕见报告
Pub Date : 2023-01-01 DOI: 10.4103/ijabmr.ijabmr_92_23
Anand Singla, Sandeep Singh, Gagandeep Kaur, Deepak Jindal, Navjot Singh, Sakini Langstang
Posterior gastric perforation is a very rare finding, difficult to diagnose due to the insidious onset of upper abdominal symptoms, and no air under the diaphragm on X-ray. Posterior gastric perforation which opens into transverse mesocolon is even rarer. This is a case report done to entail such a rare case, with only two cases reported in the past. We present the case of a 21-year-old female with pain in the epigastric region spreading to involve the whole abdomen, fever, vomiting, and anorexia. In our case, radiological findings revealed pneumoperitoneum. Intraoperatively, a tract was identified between the posterior wall of the stomach and transverse mesocolon. Tract was excised and primary repair was done using the Graham patch method.
胃后穿孔是一种非常罕见的发现,由于上腹部症状潜伏发作,x光片上膈下无空气,因此难以诊断。胃后部穿孔进入横向结肠系膜则更为罕见。这是一个罕见病例的病例报告,过去只报告了两个病例。我们报告一位21岁的女性,腹部疼痛扩散至整个腹部,伴有发烧、呕吐和厌食症。本病例影像学表现为气腹。术中发现胃后壁与横结肠系膜之间有一束。切除小束,采用Graham补片法进行初步修复。
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引用次数: 0
Lithium Toxicity - A Chameleon to Gastrointestinal Vasculitis as an Initial Presenter of Systemic Lupus Erythematosus. 锂毒性-变色龙对胃肠道血管炎的初步提示系统性红斑狼疮。
IF 1.1 Pub Date : 2023-01-01 Epub Date: 2023-03-27 DOI: 10.4103/ijabmr.ijabmr_516_22
Satyabrata Guru, Anupama Behera, Sadananda Barik, Ajitesh Sahu

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease. Gastrointestinal manifesting as nausea, vomiting, and pain abdomen are not so uncommon in SLE flare. However, gastrointestinal intestinal vasculitis as an initial presenter of SLE is very rare. This case report narrated gastrointestinal vasculitis as an initial presentation of systemic lupus erythematous, which mimicked lithium toxicity in a patient of preexisting bipolar disorder who was on long-term lithium therapy. A 26-year-old female presented with abdominal pain and persistent vomiting for 2 months. On further workup, she was antinuclear, anti-Smith, and anti-ds-DNA antibody positive. The serum lithium level was found to be normal computed tomography angiogram of the abdomen suggestive of vasculitis. A final diagnosis of SLE with gastrointestinal vasculitis as an initial presenter was made. She was treated with high-dose corticosteroid, cyclophosphamide, and other supportive care. She improved dramatically and was discharged with an oral corticosteroid, hydroxychloroquine, and ramipril.

系统性红斑狼疮(SLE)是一种多系统自身免疫性疾病。胃肠道表现为恶心、呕吐和腹部疼痛在SLE发作中并不罕见。然而,胃肠道血管炎作为SLE的最初表现者是非常罕见的。该病例报告将胃肠道血管炎描述为系统性红斑狼疮的最初表现,这与一名接受长期锂治疗的既往双相情感障碍患者的锂毒性相似。一名26岁女性,腹痛并持续呕吐2个月。在进一步的检查中,她是抗核、抗史密斯和抗ds-DNA抗体阳性。血清锂水平被发现是正常的腹部计算机断层扫描血管造影,提示血管炎。最终诊断为系统性红斑狼疮合并胃肠道血管炎为首发症状。她接受了高剂量皮质类固醇、环磷酰胺和其他支持性护理。她病情明显好转,出院时服用了皮质类固醇、羟氯喹和雷米普利。
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引用次数: 0
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International Journal of Applied and Basic Medical Research
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