International Journal of Clinical Practice最新文献

{"title":"Sex-Specific Associations of Sex Steroid Hormones With Abdominal Aortic Calcification: A Population-Based Cross-Sectional Study","authors":"Shasha Wang,&nbsp;Bing Wang,&nbsp;Zhigang Lu,&nbsp;Yesheng Pan,&nbsp;Zhijian Zhu","doi":"10.1155/ijcp/8893195","DOIUrl":"https://doi.org/10.1155/ijcp/8893195","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The purpose of our study was to examine the association of sex steroid hormones (serum total testosterone, sex hormone–binding globulin (SHBG), and estradiol) with abdominal aortic calcification (AAC) and severe AAC (SAAC) among American adults over the age of 40.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used the National Health and Nutrition Examination Survey (NHANES) data from 2013 to 2014 to conduct this study. Based on male and female, the association between sex steroid hormones and risk of AAC and SAAC was examined using multivariable logistic regression analysis and restricted cubic spline (RCS) plots.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our analysis included 2564 participants. The RCS plots showed a U-shaped curve association of estradiol with AAC, and SHBG and estradiol with the risk of SAAC in individuals who were male. Additionally, there was a negative association of serum total testosterone and SHBG with AAC risk and serum total testosterone with SAAC risk in individuals who were male. The estradiol and AAC risk also were shown to U-curve relationship in participants who were female. Finally, with the increase of serum total testosterone, the risk of AAC showed a trend of first increasing and then decreasing. The serum total testosterone, SHBG, and estradiol were inversely associated with SAAC risk, while SHBG was positively associated with AAC risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings suggest that sex steroid hormones play a role in known sex differences in AAC and SAAC in the American adult population over the age of 40.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8893195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate Cancer Radiomic Features: Limited Cross-Scanner Reproducibility Despite High Reader Reliability","authors":"Guanming Zeng,&nbsp;Xiangde Min,&nbsp;Zelin Xu,&nbsp;Subati Maimaitizunong,&nbsp;Weiyu Fan,&nbsp;Fei Qiao,&nbsp;Yan Nan,&nbsp;Ping Chen,&nbsp;Zipeng Chen,&nbsp;Xi Yin","doi":"10.1155/ijcp/4651616","DOIUrl":"https://doi.org/10.1155/ijcp/4651616","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To quantify the agreement of prostate cancer radiomic features within a reader, between readers, and across scanners for T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI; <i>b</i> = 1500 s/mm²), and apparent diffusion coefficient (ADC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Seventeen men with biopsy-proven prostate cancer underwent 3.0 T magnetic resonance imaging on two platforms. Two radiologists contoured the dominant lesion. Reader 1 repeated the segmentation approximately 4 weeks later on the same examination. For each sequence and prespecified comparison, feature-wise agreement across patients was quantified using the concordance correlation coefficient (CCC). CCCs were summarized as median (interquartile range) and categorized as poor (&lt;  0.40), moderate (0.40–0.69), good (0.70–0.89), or excellent (≥  0.90).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Within a given scanner, prostate cancer radiomic features showed consistently high agreement for both Reader 1 repeat segmentation and Reader 1 versus Reader 2, with most features in the good and excellent ranges across T2WI, DWI, and ADC. In contrast, the cross-scanner agreement was low, even for the same reader and session, and the majority of features were categorized as poor. Sequence-wise, as shown in Figure 2, adjusted T2WI outperformed DWI and ADC for cross-scanner comparisons, yet still fell short of within-scanner performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Prostate cancer radiomic features demonstrated good reproducibility on a single scanner but poor cross-scanner reproducibility. For future radiomic research, researchers should incorporate scanner type into model analyses and perform data harmonization before integrating data from different manufacturers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/4651616","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitudes, and Practices Regarding Eye Complications and Fundus Examinations Among People With Diabetes Mellitus","authors":"Hui Ding,&nbsp;Lihong Jiang,&nbsp;Hua Li,&nbsp;Qiufen He","doi":"10.1155/ijcp/6674951","DOIUrl":"https://doi.org/10.1155/ijcp/6674951","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Understanding the knowledge, attitudes, and practices (KAPs) regarding eye complications and fundus examinations among patients with diabetes mellitus (DM) is essential for early detection and prevention. This cross-sectional study aimed to investigate the KAP toward eye complications and fundus examinations among DM patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants were recruited from Zhabei Central Hospital, Jing’an District, Shanghai, between August 1, 2023, and January 15, 2024. Demographic data and KAP were collected using validated questionnaires.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 476 questionnaires (243 females; mean age: 65.6 ± 11.1 years) were analyzed. Among the participants, 40.1% had a diabetes duration of more than 10 years, and 95.8% were receiving diabetes treatment. The mean KAP scores were 6.2 ± 2.18 (range: 0–12) for knowledge, 24.75 ± 2.25 (range: 7–35) for attitude, and 8.93 ± 4.34 (range: 4–20) for practice. Only 14.7% demonstrated adequate knowledge, 51.7% had a positive attitude, and 12.0% exhibited proactive practice. Structural equation modeling showed that knowledge positively influenced attitude but had a negative direct effect on practice, while exerting a positive indirect effect on practice through attitude, indicating a suppressing mediating effect.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>DM patients exhibited inadequate knowledge, positive attitudes, and poor practices regarding diabetes-related eye complications and fundus examinations. Educational interventions should not only raise awareness but also incorporate behavioral-change strategies to translate knowledge into practice and improve diabetes eye care management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6674951","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146199380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Position Robot-Assisted Laparoscopic Nephroureterectomy for Duplicated Kidneys and Ureters: Technique and Outcomes","authors":"Wei-Cheng Sun,&nbsp;Chen-Yue Liu,&nbsp;Xiao-Yan Wang,&nbsp;Gong-Lin Tang,&nbsp;Yan-Tao Lou,&nbsp;Feng Zhang,&nbsp;Jia-Ning Sun,&nbsp;Xin Chen,&nbsp;Jun-Dong Zhao,&nbsp;Hong-Wei Zhao","doi":"10.1155/ijcp/5375627","DOIUrl":"https://doi.org/10.1155/ijcp/5375627","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Robot-assisted laparoscopic nephroureterectomy has reached a high level of maturity. The necessity of repositioning constitutes the primary surgical challenge in duplex kidney resection, which is further complicated by the extensive resection margins required. This study aims to elaborate on the technique and outcomes of single-position robot-assisted nephroureterectomy for duplicated kidneys and ureters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In our department, 23 patients diagnosed with duplicated renal collecting systems were selected. Ten patients received single-position robot-assisted laparoscopic nephroureterectomy (single-position group), while 13 underwent conventional robot-assisted laparoscopic nephroureterectomy (nonsingle-position group). We systematically collected their demographic data, surgical indications, and perioperative variables and meticulously evaluated the surgical outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All 23 patients underwent successful surgeries without conversion to open procedures. No significant differences were observed in the baseline clinical characteristics. The single-position group had a shorter operation time (166.20 ± 21.29 min vs. 208.31 ± 23.30 min, <i>p</i> &lt; 0.001) and drainage tube indwelling time (3.50 ± 0.53 days vs. 4.15 ± 0.69 days, <i>p</i> = 0.017 &lt; 0.05). Additionally, a statistically significant disparity in estimated blood loss (EBL) was noted between the two groups (136.00 ± 18.14 mL vs. 165.77 ± 40.72 mL, <i>p</i> = 0.031 &lt; 0.05). There were no differences in postoperative hospital stays and pre- and postoperative estimated glomerular filtration rate (eGFR), and no recurrence was observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Single-position robot-assisted nephroureterectomy is both a reliable and secure surgical treatment for duplicated renal collecting systems. This technique demonstrates significant advantages, including reduced operative time, decreased blood loss, fewer complications, and high success rates.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5375627","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Prostate Cancer Diagnostics: Retrospective Insights Into Transperineal Biopsy as a Primary Approach","authors":"Ali Can Albaz,&nbsp;Ali Nofel Adilov,&nbsp;Talha Müezzinoğlu","doi":"10.1155/ijcp/1594170","DOIUrl":"https://doi.org/10.1155/ijcp/1594170","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Transperineal (TP) prostate biopsy offers several advantages over transrectal (TR) prostate biopsy, including a reduced risk of infection and improved accessibility to hard-to-reach areas of the prostate. This retrospective study aims to present our clinical experience and compare the outcomes of TP and TR prostate biopsy methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed patients who underwent TP or TR prostate biopsy between January 2024 and September 2024 at the Department of Urology, Manisa Celal Bayar University Hospital. A total of 40 patients underwent TP biopsy, and 40 patients underwent TR biopsy. Data extracted included prostate-specific antigen (PSA) levels, prostate size, Prostate Imaging Reporting and Data System (PI-RADS) scores obtained from multiparametric magnetic resonance imaging (mpMRI), pain scores, postprocedural complications (e.g., infection, lower urinary tract symptoms [LUTS], and hematuria), and pathological outcomes such as overall cancer detection rates and the percentage of cancerous nuclei.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the TP biopsy group, cancer was detected in 62% of patients, compared to 45% in the TR biopsy group. Concordance between MRI imaging findings and pathology was observed in 57% of the TP group, whereas this rate was 40% in the TR group. Regarding complications, no infections were reported in the TP group, while hematuria occurred in 7% and LUTS in 17%. In the TR group, infection occurred in 7%, hematuria in 10%, and LUTS in 5% of patients. Pain scores during the procedure differed between the groups. In the TP group, the highest pain score was 4, and the most commonly reported score was 2. During probe insertion, the pain score was most frequently 2, with a maximum of 4. In the TR group, the highest pain score during the procedure was 5, and the most common score was 3. During probe insertion, the most frequent score was 3, with a maximum score of 4.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings highlight the advantages of TP biopsy, including a higher diagnostic yield, lower complication rates, and better patient-reported satisfaction. Therefore, TP biopsy should be considered the primary method for prostate biopsies in clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/1594170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146199454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Effectiveness of Dupilumab in Eosinophilic Granulomatosis With Polyangiitis: A Retrospective Observational Study","authors":"Oh Chan Kwon,&nbsp;Jang Woo Ha,&nbsp;Min-Chan Park,&nbsp;Yong-Beom Park,&nbsp;Jae-Hyun Lee,&nbsp;Sang-Won Lee","doi":"10.1155/ijcp/5773040","DOIUrl":"https://doi.org/10.1155/ijcp/5773040","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Dupilumab, a monoclonal antibody targeting the interleukin-4 receptor alpha subunit, has shown efficacy in eosinophilic disorders; however, its role in eosinophilic granulomatosis with polyangiitis (EGPA) remains uncertain. This study compared the clinical outcomes of patients with EGPA treated with conventional therapy, with or without dupilumab, focussing on its effects on disease activity and vasculitic phenotypes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods</h3>\u0000 \u0000 <p>From a prospective, single-centre cohort of patients with antineutrophil cytoplasmic antibody-associated vasculitis, we retrospectively selected three patients with EGPA who received conventional therapy with dupilumab and six age- and sex-matched patients who received conventional therapy without dupilumab. The Birmingham Vasculitis Activity Score (BVAS), peripheral eosinophil count, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels were assessed at EGPA diagnosis, dupilumab initiation and last follow-up. Changes in vascular manifestations before and after dupilumab treatment were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The eosinophilic conditions for which dupilumab was initiated were well controlled in all three patients receiving the drug. In contrast, two of the six patients who did not receive dupilumab showed worsening eosinophilic manifestations. All three patients demonstrated clinical improvement in EGPA following dupilumab treatment, with reductions in the BVAS, eosinophil count, ESR and CRP levels. No worsening of vasculitic phenotypes was observed, even after prolonged exposure (up to 45 months).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Dupilumab may help control the eosinophilic phenotypes of EGPA, thereby contributing to overall disease activity control without exacerbating vasculitic phenotypes. However, given the small sample size and retrospective nature of this study, larger prospective trials are required to confirm its efficacy in EGPA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5773040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146199455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Olfactory Dysfunction and Cognitive Decline: Impacts, Mechanisms, and Potential Interventions","authors":"Chenyang Lei,&nbsp;Li Cao,&nbsp;Juan Jiang,&nbsp;Jipin Hu,&nbsp;Gaoyun Xiong,&nbsp;Shanguang Lv","doi":"10.1155/ijcp/5582661","DOIUrl":"https://doi.org/10.1155/ijcp/5582661","url":null,"abstract":"<p>Olfactory dysfunction (OD) has been identified as a potential indicator closely related to cognitive decline (CD). This review explores the complex connection between olfactory and cognitive function, with a focus on the nose–brain axis. We summarize recent evidence linking OD of various etiologies to CD and discuss how this relationship depends on the specific disease. The review also addresses neuroanatomical changes in OD and CD and potential mechanisms underpinning the OD–CD relationship, including inflammatory response, oxidative stress, and microbiota–gut/nose–brain communication. Despite progress in elucidating these pathological mechanisms, challenges persist in applying these findings to effective clinical applications. Additionally, this review assesses new therapeutic interventions, particularly olfactory training (OT), which demonstrates potential in improving both olfactory and cognitive functions. By synthesizing this evidence, this article seeks to provide a comprehensive overview of the bidirectional relationships between olfaction and cognition and advance diagnostic and rehabilitative strategies for patients with OD and CD.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5582661","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146199425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticoagulant or Antithrombotic Therapy After Early Neurological Deterioration in Patients With Branch Atheromatous Disease Receiving Dual Antiplatelet Therapy","authors":"Xuemin Zhong,&nbsp;Juan Yang,&nbsp;Ronghua Xu,&nbsp;Jian Wang","doi":"10.1155/ijcp/8636214","DOIUrl":"https://doi.org/10.1155/ijcp/8636214","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We evaluated the effectiveness and safety of adding tirofiban or argatroban after early neurological deterioration (END) in patients with branch atheromatous disease (BAD) receiving dual antiplatelet therapy and compared the outcomes with those of patients who continued dual antiplatelet therapy alone.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study focused on 135 consecutive patients with BAD and END between June 2019 and June 2021. The primary and secondary efficacy endpoints were a modified Rankin scale (mRS) score of ≤ 2 at 90 days after stroke and a National Institutes of Health Stroke Scale (NIHSS) score on Day 7 after END. Safety outcomes included other bleeding and mortality events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 65, 33, and 37 patients were included in the dual antiplatelet therapy (DAPT), argatroban, and tirofiban groups, respectively. There was a statistically significant difference in the clinical outcome (mRS 0–2) among the three groups (<i>p</i> = 0.001). Post hoc test analysis showed that the proportion of good outcomes in the tirofiban group was significantly higher than that in the argatroban and DAPT groups (<i>p</i> = 0.011, &lt; 0.001, Bonferroni corrected). The NIHSS score of the tirofiban group (3.32 ± 1.81) on Day 7 was significantly lower than that of the argatroban (6.24 ± 3.18) and DAPT (5.62 ± 3.25) groups (<i>p</i> &lt; 0.01). No severe bleeding and mortality events were observed in any of the three groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Following END in patients with BAD receiving DAPT, adding tirofiban to the existing treatment results in a higher proportion of favorable clinical outcomes (mRS 0–2) and a lower 7-day NIHSS score. It also demonstrates good safety while improving prognosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8636214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneity and Therapeutic Potential of Programmed Cell Death Pathways in STMN1+ EPCs in Cutaneous T-Cell Lymphoma","authors":"Huan Yao,&nbsp;Yiyi Liu,&nbsp;Chengcheng Song,&nbsp;Mengnan Fan,&nbsp;Cuicui Wang,&nbsp;Yuwei Sun","doi":"10.1155/ijcp/4527545","DOIUrl":"https://doi.org/10.1155/ijcp/4527545","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Primary cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group of T-cell lymphomas that begin with skin manifestations. In advanced mycosis fungoides (MF), as MF reached advanced stages, the lesions disseminated beyond the skin, involving lymph nodes and blood, which further worsened the prognosis. As no reliable malignancy markers were identified, diagnostic challenges occurred and influenced prognosis. CTCL was usually indolent; however, it progressed quickly in some patients and exhibited variable therapeutic responses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study used GEO scRNA-seq data to analyze CTCL heterogeneity. Differential expression and enrichment analyses clarified immune and drug pathways. Monocle and CytoTRACE mapped cell trajectories, while CellChat and pySCENIC revealed intercellular communication and transcriptional regulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>CTCL heterogeneity was uncovered by scRNA-seq, which identified malignant subtypes driving progression. Pathway analysis connected oxidative phosphorylation, glycolysis, and pyruvate metabolism with cellular stability, while EPCs engaged TME communication via MIF signaling to advance disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We examined the role of C3 <i>STMN1+</i> EPCs in CTCL and discovered that this EPC subtype facilitates tumor progression, immune evasion, and angiogenesis. The C3 subtype’s heightened malignancy and specific cell cycle traits are tied to DNA replication and genomic stability. Single-cell sequencing reveals CTCL heterogeneity and underscores the potential for personalized treatment strategies. Although our study has a limited sample size, it identifies C3 <i>STMN1+</i> EPCs as potential biomarkers and therapeutic targets for CTCL, necessitating further research for broader clinical validation and offering new prospects for CTCL treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/4527545","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Adverse Outcomes via Simple Assessment Tools Among Older Inpatients With Nonsevere COVID-19: The SARC-F Score, FRAIL Scale, and G8 Questionnaire","authors":"Betul Cigdem Yortanli,&nbsp;Muhammet Cemal Kizilarslanoglu,&nbsp;Betul Kozanhan,&nbsp;Ibrahim Solak,&nbsp;Fatma Kacar,&nbsp;Dilek Ates,&nbsp;Mehmet Mermer,&nbsp;Korhan Kollu","doi":"10.1155/ijcp/8845077","DOIUrl":"https://doi.org/10.1155/ijcp/8845077","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To investigate the predictive ability of the SARC-F score, FRAIL scale, and G8 questionnaire on adverse clinical outcomes in older inpatients with COVID-19.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 141 patients (50.4% male) were included in this prospective cohort study and assessed by the SARC-F score (for sarcopenia risk), FRAIL scale (for frailty status), and G8 questionnaire (for vulnerability risk) on the first day of hospitalization. The outcomes, including length of stay (LOS), need for intensive care unit (ICU) admission (NICUA), and mortality, were recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Median age was 71 years (median LOS, 9 days; NICUA, 15.6%; and in-hospital mortality, 2.8%). The patients’ frailty, sarcopenia risk, and vulnerability rates were 43.3%, 37.6%, and 52.5%, respectively. Crude regression models showed that sarcopenia risk (odds ratio (OR): 10.800; <i>p</i> &lt; 0.001), frailty (OR: 4.385; <i>p</i> = 0.002), and vulnerability (OR: 12.037; <i>p</i> &lt; 0.001) might be related factors for the NICUA. All scales showed good predictive performance in ROC curve analyses. For predicting the need for intensive care unit admission, the AUC values were 0.696 for the FRAIL scale, 0.769 for the SARC–F-score, and 0.785 for the G8 questionnaire. For in-hospital mortality, the corresponding AUC values were 0.792, 0.799, and 0.822, respectively (all <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study suggests that the mentioned assessment tools might predict worse clinical outcomes among the study population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8845077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146057696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}