Xingyu Fang, Haonan Bai, Zhanhong Cao, Dianyu Li, Yu An, Xiaohui Zhao, Nan Chen
Pulmonary fibrosis is a significant lung injury caused by multiple factors that profoundly affect the human quality of life. Currently, various animal models are used to understand the aetiology of pulmonary fibrosis and develop treatments. However, only pharmacogenetic models of pulmonary fibrosis have been discussed, and there have been no reviews of drug treatments. This study reviewed research articles as of August 2023 in major literature databases outlining different techniques for animal modelling of pulmonary fibrosis, including pharmacogenetic and nonpharmacogenetic approaches. Additionally, treatment approaches from both Western and traditional Chinese medicine are discussed. Study results show that along with commonly recognised medications such as pirfenidone and nintedanib, many traditional Chinese remedies and natural products, such as resveratrol and Qingfei Paidu, also offer preventative and therapeutic effects against pulmonary fibrosis.
{"title":"Animal Models and Treatment of Pulmonary Fibrosis: Pharmacogenetic and Nonpharmacogenetic","authors":"Xingyu Fang, Haonan Bai, Zhanhong Cao, Dianyu Li, Yu An, Xiaohui Zhao, Nan Chen","doi":"10.1155/ijcp/4075978","DOIUrl":"https://doi.org/10.1155/ijcp/4075978","url":null,"abstract":"<p>Pulmonary fibrosis is a significant lung injury caused by multiple factors that profoundly affect the human quality of life. Currently, various animal models are used to understand the aetiology of pulmonary fibrosis and develop treatments. However, only pharmacogenetic models of pulmonary fibrosis have been discussed, and there have been no reviews of drug treatments. This study reviewed research articles as of August 2023 in major literature databases outlining different techniques for animal modelling of pulmonary fibrosis, including pharmacogenetic and nonpharmacogenetic approaches. Additionally, treatment approaches from both Western and traditional Chinese medicine are discussed. Study results show that along with commonly recognised medications such as pirfenidone and nintedanib, many traditional Chinese remedies and natural products, such as resveratrol and Qingfei Paidu, also offer preventative and therapeutic effects against pulmonary fibrosis.</p>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/4075978","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145963867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
More evidence is required to determine the physical therapists’ perception and knowledge about clinical practice guidelines (CPGs).
Objectives
The main purpose of this study is to explore the physical therapists’ knowledge, attitude, and practice toward CPGs in Saudi Arabia.
Methods
A cross-sectional study was conducted among 115 physical therapists in Saudi Arabia. Data were collected through a self-administered electronic survey to assess the association between participants’ demographic and work data with CPG familiarity and evidence-based practice (EBP) understanding. Data were analyzed using descriptive statistics and multivariable ordinal logistic regression.
Results
The study revealed that 81.7% of the participants indicated familiarity with CPG, with 94% having received prior education on the topic, mostly through 29% of postgraduate studies. About 50% of the participants reported that they always use CPGs when relevant. Participants who had a higher educational level showed more positive attitudes and greater levels of familiarity with CPG and EBP. Regarding the barriers of applying CPG recommendations, the highest two barriers were lack of time (63.5%) and work-limited resources (57.5%).
Conclusion
Despite familiarity and positive attitudes toward CPGs, adherence among physical therapists in Saudi Arabia was limited due to barriers such as lack of time, resources, and insufficient training.
{"title":"Knowledge, Attitude, and Practice Related to Clinical Practice Guidelines Among Physical Therapists","authors":"Muataz Almaddah, Afnan Gmmash, Samiah Alqabbani, Mashael Alsobhi","doi":"10.1155/ijcp/4032737","DOIUrl":"https://doi.org/10.1155/ijcp/4032737","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>More evidence is required to determine the physical therapists’ perception and knowledge about clinical practice guidelines (CPGs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The main purpose of this study is to explore the physical therapists’ knowledge, attitude, and practice toward CPGs in Saudi Arabia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted among 115 physical therapists in Saudi Arabia. Data were collected through a self-administered electronic survey to assess the association between participants’ demographic and work data with CPG familiarity and evidence-based practice (EBP) understanding. Data were analyzed using descriptive statistics and multivariable ordinal logistic regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study revealed that 81.7% of the participants indicated familiarity with CPG, with 94% having received prior education on the topic, mostly through 29% of postgraduate studies. About 50% of the participants reported that they always use CPGs when relevant. Participants who had a higher educational level showed more positive attitudes and greater levels of familiarity with CPG and EBP. Regarding the barriers of applying CPG recommendations, the highest two barriers were lack of time (63.5%) and work-limited resources (57.5%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Despite familiarity and positive attitudes toward CPGs, adherence among physical therapists in Saudi Arabia was limited due to barriers such as lack of time, resources, and insufficient training.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2026 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/4032737","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145904661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although several algorithms have been proposed to predict individual warfarin doses, the relationships between the international normalized ratio (INR) and cumulative warfarin dose remain to be determined.
Objectives
The aim of this study was to explore the correlation between the INR and the cumulative dosage of warfarin within a week in patients who have undergone mechanical heart valve replacement.
Methods
A retrospective study was conducted at the First Affiliated Hospital of Shantou University Medical College in southern China. Fifty-two patients who underwent mechanical heart valve replacement between January 2016 and December 2022 were included. The daily warfarin dose, cumulative dosage of warfarin within a week, and INR value were recorded. A simple linear regression model was used to analyze the correlation between the INR and cumulative warfarin dosage within a week.
Results
Of the 52 patients who underwent mechanical heart valve replacement, 19 were male, and 33 were female. Twenty-three and 18 patients had undergone mitral valve replacement and aortic valve replacement, respectively. Eleven patients underwent both mitral and aortic valve replacement. There was a strong linear correlation in 35 patients (67.31%), with a correlation coefficient (adjusted R2 ≥ 0.7) identified between the INR and the cumulative dosage of warfarin within a week. The patients with weak correlations (adjusted R2 < 0.7) were more likely to be female and have lower left ventricular ejection fractions, fewer days and lower cumulative warfarin doses at the first time of therapeutic INR. Multivariate logistic regression analysis revealed that none of these factors significantly affected the relationship between the INR and cumulative warfarin dose.
Conclusion
Our study revealed a strong linear correlation between the INR and the cumulative dosage of warfarin within a week in most patients with mechanical prosthetic heart valves.
{"title":"Association Between the INR and Warfarin Dose in Patients With Mechanical Prosthetic Heart Valves","authors":"Jing Cao, Shan Zou, Xiaoqing Dai, Wan Lin, Zhengyu Lin, Xinyin Xie, Hui Zeng, Xuanyan Zhong, Hongjuan Chen, Xiaoli Ou, Min Yu","doi":"10.1155/ijcp/5428329","DOIUrl":"https://doi.org/10.1155/ijcp/5428329","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Although several algorithms have been proposed to predict individual warfarin doses, the relationships between the international normalized ratio (INR) and cumulative warfarin dose remain to be determined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this study was to explore the correlation between the INR and the cumulative dosage of warfarin within a week in patients who have undergone mechanical heart valve replacement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective study was conducted at the First Affiliated Hospital of Shantou University Medical College in southern China. Fifty-two patients who underwent mechanical heart valve replacement between January 2016 and December 2022 were included. The daily warfarin dose, cumulative dosage of warfarin within a week, and INR value were recorded. A simple linear regression model was used to analyze the correlation between the INR and cumulative warfarin dosage within a week.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 52 patients who underwent mechanical heart valve replacement, 19 were male, and 33 were female. Twenty-three and 18 patients had undergone mitral valve replacement and aortic valve replacement, respectively. Eleven patients underwent both mitral and aortic valve replacement. There was a strong linear correlation in 35 patients (67.31%), with a correlation coefficient (adjusted <i>R</i><sup>2</sup> ≥ 0.7) identified between the INR and the cumulative dosage of warfarin within a week. The patients with weak correlations (adjusted <i>R</i><sup>2</sup> < 0.7) were more likely to be female and have lower left ventricular ejection fractions, fewer days and lower cumulative warfarin doses at the first time of therapeutic INR. Multivariate logistic regression analysis revealed that none of these factors significantly affected the relationship between the INR and cumulative warfarin dose.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our study revealed a strong linear correlation between the INR and the cumulative dosage of warfarin within a week in most patients with mechanical prosthetic heart valves.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5428329","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic kidney disease (CKD) affects approximately 850 million people worldwide, with limited therapeutic options. Plasma proteins, as major sources of therapeutic targets, may play a significant role in the pathophysiology of CKD.
Objective
This study aims to evaluate the causal relationship between 4907 plasma proteins and CKD using bidirectional Mendelian randomization (MR) to identify potential therapeutic targets.
Methods
The bidirectional MR study utilized genetic data from a genome-wide association study (GWAS) involving 10,039 CKD cases and 396,706 controls from the Finnish database. Plasma protein data were obtained from a GWAS summary of 35,559 healthy participants. The causal relationship was primarily investigated using the inverse-variance weighted method, supplemented by MR-Egger, weighted median, and weighted mode analyses. Heterogeneity of the results was assessed using Cochran’s Q test. Horizontal pleiotropy was evaluated by the MR-Egger intercept test and the MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test. Sensitivity analysis was performed using leave-one-out analysis.
Results
MR analysis revealed that several plasma proteins are directly causally related to CKD. Increased levels of nine plasma proteins, including CHCHD10, NBR1, SLC5A5, TOM1L1, PSME1, IL23R, CRYZL1, HERC5, and RARRES1, were associated with increased CKD risk. Conversely, elevated levels of three proteins, UCMA, FTMT, and H6PD, were associated with reduced CKD risk, with FTMT and H6PD showing particularly strong associations. Reverse MR analysis demonstrated that CKD itself does not exert a direct causal effect on the levels of these proteins. Functional enrichment and gene interaction network analyses further revealed the potential roles of these proteins in the pathophysiological processes.
Conclusion
These findings confirmed the causal relationships between specific plasma proteins and CKD and excluded a causal effect of CKD on the levels of these proteins, providing new targets for early prevention and treatment of the disease.
{"title":"Exploring the Causal Relationship Between Plasma Proteins and Chronic Kidney Disease: A Bidirectional Mendelian Randomization Study","authors":"Minghui Li, Haiyan Xian, Haiming Wen, Fei Lin","doi":"10.1155/ijcp/1620972","DOIUrl":"https://doi.org/10.1155/ijcp/1620972","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic kidney disease (CKD) affects approximately 850 million people worldwide, with limited therapeutic options. Plasma proteins, as major sources of therapeutic targets, may play a significant role in the pathophysiology of CKD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to evaluate the causal relationship between 4907 plasma proteins and CKD using bidirectional Mendelian randomization (MR) to identify potential therapeutic targets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The bidirectional MR study utilized genetic data from a genome-wide association study (GWAS) involving 10,039 CKD cases and 396,706 controls from the Finnish database. Plasma protein data were obtained from a GWAS summary of 35,559 healthy participants. The causal relationship was primarily investigated using the inverse-variance weighted method, supplemented by MR-Egger, weighted median, and weighted mode analyses. Heterogeneity of the results was assessed using Cochran’s <i>Q</i> test. Horizontal pleiotropy was evaluated by the MR-Egger intercept test and the MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test. Sensitivity analysis was performed using leave-one-out analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MR analysis revealed that several plasma proteins are directly causally related to CKD. Increased levels of nine plasma proteins, including CHCHD10, NBR1, SLC5A5, TOM1L1, PSME1, IL23R, CRYZL1, HERC5, and RARRES1, were associated with increased CKD risk. Conversely, elevated levels of three proteins, UCMA, FTMT, and H6PD, were associated with reduced CKD risk, with FTMT and H6PD showing particularly strong associations. Reverse MR analysis demonstrated that CKD itself does not exert a direct causal effect on the levels of these proteins. Functional enrichment and gene interaction network analyses further revealed the potential roles of these proteins in the pathophysiological processes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings confirmed the causal relationships between specific plasma proteins and CKD and excluded a causal effect of CKD on the levels of these proteins, providing new targets for early prevention and treatment of the disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/1620972","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabiana Nery Ribeiro Oliveira, Fernando de Aguiar Lemos, Thaís Ferreira Lopes Diniz Maia, Maria Deborah Monteiro de Albuquerque, Armèle Dornelas de Andrade, Paulo André Freire Magalhães
Objective
To examine the association between cough peak flow (CPF) and dysphagia risk in patients with acute brain injury.
Design
Observational, analytical, cross-sectional study.
Setting
A university hospital located in the northeastern region of Brazil.
Participants
A sample of 108 adult patients diagnosed with acute brain injury (stroke or traumatic brain injury) was examined. The mean age of the participants was 53.4 ± 15.2 years, with 64% of the subjects being male. The patient’s swallowing assessments and CPF measurements were obtained during the patient’s stay in the hospital.
Main Outcome Measures
The severity of dysphagia risk was evaluated through the implementation of a bedside clinical swallowing protocol. The measurement of CPF was conducted by means of a portable peak expiratory flow meter. Logistic regression and receiver operating characteristic (ROC) curve analyses with bootstrap resampling were used to analyze the relationship between CPF and dysphagia risk. Additionally, secondary associations with age and body mass index were examined using the Spearman rank correlation test.
Results
Dysphagia risk was identified in 44% of patients. A cutoff value of 202 L/min on the CPF predicted dysphagia risk with 82% sensitivity and 83% specificity. A lack of statistically significant disparities in CPF was observed across different lesion types. The present study demonstrated a strong negative correlation between CPF and dysphagia risk (ρ = −0.791, p < 0.001).
Conclusions
The CPF demonstrated high sensitivity and specificity in identifying patients at dysphagia risk following acute brain injury. Its ease of use and noninvasive nature make it a promising adjunctive screening tool for clinical swallowing evaluations.
目的探讨急性脑损伤患者咳嗽峰流量（CPF）与吞咽困难的关系。设计观察性、分析性、横断面研究。位于巴西东北部地区的一所大学医院。研究了108例诊断为急性脑损伤（中风或创伤性脑损伤）的成年患者。参与者的平均年龄为53.4±15.2岁，男性占64%。患者在住院期间进行吞咽评估和CPF测量。主要观察指标：通过床边临床吞咽方案的实施评估吞咽困难风险的严重程度。CPF的测定采用便携式呼气峰流量仪。采用Logistic回归和自举重采样的受试者工作特征（ROC）曲线分析CPF与吞咽困难风险的关系。此外，使用Spearman秩相关检验检验年龄和体重指数的二级关联。结果44%的患者存在吞咽困难风险。CPF的临界值为202 L/min，预测吞咽困难风险的敏感性为82%，特异性为83%。在不同的病变类型中观察到CPF缺乏统计学上的显著差异。本研究显示CPF与吞咽困难风险之间存在很强的负相关（ρ = - 0.791, p < 0.001）。结论CPF对急性脑损伤后吞咽困难患者具有较高的敏感性和特异性。它的易用性和无创性使其成为临床吞咽评估的一个很有前途的辅助筛查工具。
{"title":"Does Cough Peak Flow Hold the Key to Safer Swallowing Assessments in Acute Brain Injury?","authors":"Fabiana Nery Ribeiro Oliveira, Fernando de Aguiar Lemos, Thaís Ferreira Lopes Diniz Maia, Maria Deborah Monteiro de Albuquerque, Armèle Dornelas de Andrade, Paulo André Freire Magalhães","doi":"10.1155/ijcp/6032315","DOIUrl":"https://doi.org/10.1155/ijcp/6032315","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To examine the association between cough peak flow (CPF) and dysphagia risk in patients with acute brain injury.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Observational, analytical, cross-sectional study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>A university hospital located in the northeastern region of Brazil.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Participants</h3>\u0000 \u0000 <p>A sample of 108 adult patients diagnosed with acute brain injury (stroke or traumatic brain injury) was examined. The mean age of the participants was 53.4 ± 15.2 years, with 64% of the subjects being male. The patient’s swallowing assessments and CPF measurements were obtained during the patient’s stay in the hospital.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>The severity of dysphagia risk was evaluated through the implementation of a bedside clinical swallowing protocol. The measurement of CPF was conducted by means of a portable peak expiratory flow meter. Logistic regression and receiver operating characteristic (ROC) curve analyses with bootstrap resampling were used to analyze the relationship between CPF and dysphagia risk. Additionally, secondary associations with age and body mass index were examined using the Spearman rank correlation test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Dysphagia risk was identified in 44% of patients. A cutoff value of 202 L/min on the CPF predicted dysphagia risk with 82% sensitivity and 83% specificity. A lack of statistically significant disparities in CPF was observed across different lesion types. The present study demonstrated a strong negative correlation between CPF and dysphagia risk (<i>ρ</i> = −0.791, <i>p</i> < 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The CPF demonstrated high sensitivity and specificity in identifying patients at dysphagia risk following acute brain injury. Its ease of use and noninvasive nature make it a promising adjunctive screening tool for clinical swallowing evaluations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6032315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Silvia M. Pol, Victoria M. Link, Heidi Toivonen, Floortje E. Scheepers, Constance H. C. Drossaert
<div> <section> <h3> Objective</h3> <p>Narrative interventions show promise in reducing trauma symptoms, self-stigma, and depression. However, a systematic review of various narrative approaches for a broad range of mental health conditions is missing. This study explores the characteristics, effectiveness, and experiences of participants and counselors in existing narrative interventions for people with mental disorders, including personality disorders.</p> </section> <section> <h3> Method</h3> <p>This mixed-methods systematic review searched PsychINFO, PubMed, Scopus, Web of Science, and Ovid Embase, including forward and backward citations, for studies published up to December 22, 2023. Included were peer-reviewed, empirical research articles (quantitative and qualitative), written in English, about life stories or self-defining memories, and targeting people with psychopathology. Excluded were interventions focusing solely on mental flourishing, cognition, autobiographical memories, children, and people with dementia. Two researchers independently selected studies and assessed evidence quality using the Mixed-Methods Appraisal Tool. Metasynthesis integrated quantitative effects and qualitative evaluations by participants and counselors. This study is registered on PROSPERO (2024 CRD42024526703).</p> </section> <section> <h3> Results</h3> <p>Of 1451 records identified, 36 studies met the inclusion criteria, all with low to moderate overall bias. Most studies were published between 2004 and 2024, mainly in the last decade, and focused on various mental disorders. Interventions were categorized into four types: Narrative Exposure Therapy (14 studies), Narrative Enhancement and Cognitive Therapy (5 studies), Reminiscence therapies (8 studies), and other narrative interventions (9 studies). Interventions targeted individuals and groups, consisting of 1–20 sessions. Symptoms related to trauma, depression, anxiety, and self-stigma were consistently reduced, while positive mental health aspects were less frequently assessed. Qualitative synthesis revealed three themes: appreciation of interventions, changes in identity, and changes in recovery. There was minimal overlap between quantitative and qualitative outcomes; aspects of high interest to participants were often not reflected in outcome measurements.</p> </section> <section> <h3> Conclusion</h3> <p>Narrative interventions offer a promising and innovative approach to treating mental disorders, effectively improving psychopathological symptoms with small to large effect sizes. Positive and process-related outcom
目的叙事性干预在减少创伤症状、自我耻辱和抑郁方面显示出希望。然而，对各种叙事方法对广泛的精神健康状况的系统审查是缺失的。本研究探讨了现有精神障碍（包括人格障碍）患者叙事干预的特点、有效性和参与者和咨询师的经验。方法采用混合方法进行系统评价，检索PsychINFO、PubMed、Scopus、Web of Science和Ovid Embase，检索截止到2023年12月22日发表的研究，包括前向和后向引文。其中包括同行评议的实证研究文章（定量和定性），用英语写的，关于生活故事或自我定义的记忆，目标人群是精神病理患者。排除了仅关注精神发育、认知、自传式记忆、儿童和痴呆症患者的干预措施。两名研究人员独立选择研究并使用混合方法评估工具评估证据质量。统合综合了参与者和咨询师的定量效果和定性评价。本研究已在PROSPERO注册（2024 CRD42024526703）。结果在1451份文献中，36项研究符合纳入标准，均为低至中等偏倚。大多数研究发表于2004年至2024年之间，主要是在过去十年，重点关注各种精神障碍。干预措施分为四类：叙事暴露疗法（14项研究）、叙事强化与认知疗法（5项研究）、回忆疗法（8项研究）和其他叙事干预（9项研究）。干预措施针对个人和群体，由1-20次会议组成。与创伤、抑郁、焦虑和自我耻辱相关的症状持续减少，而积极的心理健康方面的评估频率较低。定性综合揭示了三个主题：干预措施的欣赏，身份的变化和恢复的变化。定量和定性结果之间的重叠很少；参与者高度感兴趣的方面往往没有反映在结果测量中。结论叙事性干预是治疗精神障碍的一种有前景的创新方法，可有效改善精神病理症状，效果大小不等。积极的和过程相关的结果较少被测量，并且在显著性上有所不同。未来的研究应该持续评估积极的结果，如身份、恢复、生活意义、自尊、希望和生活质量，以及精神病理结果，为叙事干预的有效性提供更广泛的证据。
{"title":"Narrative Interventions for Persons With Mental Disorders Including Personality Disorders: A Mixed-Methods Systematic Review","authors":"Silvia M. Pol, Victoria M. Link, Heidi Toivonen, Floortje E. Scheepers, Constance H. C. Drossaert","doi":"10.1155/ijcp/5023850","DOIUrl":"https://doi.org/10.1155/ijcp/5023850","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Narrative interventions show promise in reducing trauma symptoms, self-stigma, and depression. However, a systematic review of various narrative approaches for a broad range of mental health conditions is missing. This study explores the characteristics, effectiveness, and experiences of participants and counselors in existing narrative interventions for people with mental disorders, including personality disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This mixed-methods systematic review searched PsychINFO, PubMed, Scopus, Web of Science, and Ovid Embase, including forward and backward citations, for studies published up to December 22, 2023. Included were peer-reviewed, empirical research articles (quantitative and qualitative), written in English, about life stories or self-defining memories, and targeting people with psychopathology. Excluded were interventions focusing solely on mental flourishing, cognition, autobiographical memories, children, and people with dementia. Two researchers independently selected studies and assessed evidence quality using the Mixed-Methods Appraisal Tool. Metasynthesis integrated quantitative effects and qualitative evaluations by participants and counselors. This study is registered on PROSPERO (2024 CRD42024526703).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 1451 records identified, 36 studies met the inclusion criteria, all with low to moderate overall bias. Most studies were published between 2004 and 2024, mainly in the last decade, and focused on various mental disorders. Interventions were categorized into four types: Narrative Exposure Therapy (14 studies), Narrative Enhancement and Cognitive Therapy (5 studies), Reminiscence therapies (8 studies), and other narrative interventions (9 studies). Interventions targeted individuals and groups, consisting of 1–20 sessions. Symptoms related to trauma, depression, anxiety, and self-stigma were consistently reduced, while positive mental health aspects were less frequently assessed. Qualitative synthesis revealed three themes: appreciation of interventions, changes in identity, and changes in recovery. There was minimal overlap between quantitative and qualitative outcomes; aspects of high interest to participants were often not reflected in outcome measurements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Narrative interventions offer a promising and innovative approach to treating mental disorders, effectively improving psychopathological symptoms with small to large effect sizes. Positive and process-related outcom","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/5023850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hou Huang, Jiaming Yu, Xianlong Li, Ming Ling, Chaobao Zhang, Yongqian Fan
Background
Osteoporosis is a foremost public health challenge, especially with the global aging population. Both frailty and osteoporosis share many risk factors, although the relationship between them remains partially explored. This study aims to explore the correlation between varying frailty statuses and osteoporosis incidence.
Methods
Participants from the 2017–2018 NHANES were classified into three groups: frailty, prefrailty, and robust, based on the frailty phenotype. The correlation between frailty and osteoporosis prevalence was assessed using weighted multivariate logistic regression models. Causal relationship was verified by Mendelian randomization using frailty data from the U.K. Biobank and osteoporosis data from the FinnGen database. Proteomic analysis including associated protein screening and functional enrichments was performed based on data from the Icelandic cohort.
Results
The study group comprised 1814 participants. An increased incidence of osteoporosis was observed in older age and lower body mass index populations. A significant frailty–osteoporosis correlation (odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.14–1.64; p = 0.001) was indicated both in the crude model and after adjustments (OR: 1.23; 95% CI: 1.01–1.51; p = 0.039). The inverse variance weighting method observed a potential effect of frailty on osteoporosis risk (β/SE, 0.209/0.099; OR: 1.233; 95% CI: 1.014–1.499; p = 0.036). Thirteen frailty–osteoporosis-associated proteins were found, and proteomic enrichment indicated oxidative stress-related pathways as a hypothesis-generating mechanism of frailty-mediated osteoporosis.
Conclusions
Our findings suggest a potential causal association between frailty and osteoporosis, with risk exacerbating with the progression of frailty severity. Frailty potentially impacts the progression of osteoporosis through response to oxidative stress.
骨质疏松症是一个重要的公共卫生挑战，特别是随着全球人口老龄化。虚弱和骨质疏松都有许多共同的危险因素，尽管它们之间的关系仍有待部分探索。本研究旨在探讨不同虚弱状态与骨质疏松发病率之间的关系。方法根据脆弱表型，将2017-2018年NHANES的参与者分为虚弱、脆弱和健壮三组。使用加权多变量logistic回归模型评估虚弱和骨质疏松患病率之间的相关性。因果关系通过孟德尔随机化验证，使用来自英国生物银行的脆弱性数据和来自FinnGen数据库的骨质疏松症数据。蛋白质组学分析，包括相关蛋白质筛选和功能富集，基于冰岛队列的数据进行。结果研究组共纳入1814名受试者。骨质疏松症的发病率在老年和低体重指数人群中增加。在原始模型和调整后的模型中，虚弱与骨质疏松均存在显著相关性（优势比[OR]: 1.37； 95%可信区间[CI]: 1.14-1.64; p = 0.001） （OR: 1.23; 95% CI: 1.01-1.51; p = 0.039）。反方差加权法观察到虚弱对骨质疏松风险的潜在影响（β/SE, 0.209/0.099; OR: 1.233; 95% CI: 1.014-1.499; p = 0.036）。13个脆弱骨质疏松相关蛋白被发现，蛋白质组学富集表明氧化应激相关途径是脆弱介导的骨质疏松的假设产生机制。结论：我们的研究结果表明，虚弱和骨质疏松之间存在潜在的因果关系，并且随着虚弱严重程度的进展，风险加剧。虚弱可能通过对氧化应激的反应影响骨质疏松症的进展。
{"title":"Frailty Promotes Osteoporosis Development via Oxidative Stress: Evidence From Multicohort and Proteomic Analyses","authors":"Hou Huang, Jiaming Yu, Xianlong Li, Ming Ling, Chaobao Zhang, Yongqian Fan","doi":"10.1155/ijcp/6662987","DOIUrl":"https://doi.org/10.1155/ijcp/6662987","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Osteoporosis is a foremost public health challenge, especially with the global aging population. Both frailty and osteoporosis share many risk factors, although the relationship between them remains partially explored. This study aims to explore the correlation between varying frailty statuses and osteoporosis incidence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants from the 2017–2018 NHANES were classified into three groups: frailty, prefrailty, and robust, based on the frailty phenotype. The correlation between frailty and osteoporosis prevalence was assessed using weighted multivariate logistic regression models. Causal relationship was verified by Mendelian randomization using frailty data from the U.K. Biobank and osteoporosis data from the FinnGen database. Proteomic analysis including associated protein screening and functional enrichments was performed based on data from the Icelandic cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study group comprised 1814 participants. An increased incidence of osteoporosis was observed in older age and lower body mass index populations. A significant frailty–osteoporosis correlation (odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.14–1.64; <i>p</i> = 0.001) was indicated both in the crude model and after adjustments (OR: 1.23; 95% CI: 1.01–1.51; <i>p</i> = 0.039). The inverse variance weighting method observed a potential effect of frailty on osteoporosis risk (β/SE, 0.209/0.099; OR: 1.233; 95% CI: 1.014–1.499; <i>p</i> = 0.036). Thirteen frailty–osteoporosis-associated proteins were found, and proteomic enrichment indicated oxidative stress-related pathways as a hypothesis-generating mechanism of frailty-mediated osteoporosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings suggest a potential causal association between frailty and osteoporosis, with risk exacerbating with the progression of frailty severity. Frailty potentially impacts the progression of osteoporosis through response to oxidative stress.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/6662987","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammed Alnaggar, Mueataz A. Mahyoub, Wen Cheng, Weiwei Huang, Yalin Xu, Shengzhou Wang, Ting Chen, Jamal Alshorman
Background
Diarrhea constitutes a significant complication among colorectal cancer (CRC) patients undergoing cytotoxic chemotherapy, impacting both their quality of life and treatment adherence. We aimed to assess the safety and efficacy of fecal microbiota transplantation (FMT) in severe chemotherapy-induced diarrhea (CID) among patients with CRC.
Materials and Methods
We conducted an open-label, single-arm trial involving 20 patients with CRC experiencing severe CID (grade 2 or 3) as defined by the Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0, in whom conventional standard antidiarrheal treatments were ineffective. Patients received a single course of orally administered FMT capsules, with a protocol allowing for a repeat course at a 2-week interval if needed. Each course consisted of 90 capsules (10 capsules three times daily on Days 1, 2, and 3), delivering approximately 180 × 1010 colony-forming units (CFU) of bacteria. Patients were monitored for 12 weeks. The primary endpoint was the proportion of patients achieving a sustained clinical response (diarrhea reduced to less than six unformed bowel movements per day). Secondary endpoints included changes in gut microbiome composition and immune cell populations. Genomic analysis (16S rRNA gene sequencing) and immune cell phenotyping (flow cytometry) were performed on samples collected before and after FMT.
Results
The overall response rate, characterized by the improvement of diarrhea to less than six unformed bowel movements per day following one or more FMT procedures over a minimum period of 12 weeks, was noted in 85% (17/20) of patients (95% confidence interval [CI], [62.1%, 96.8%]). Genomic analysis demonstrated significant improvements in gut microbiome diversity after FMT. Moreover, it revealed significant alterations in immune cell populations post-FMT. Specifically, we observed a statistically significant increase in CD19+ B cells (p = 0.0001), CD3+ CD8+ T cytotoxic cells (p = 0.0010), and natural killer (NK) cells (p = 0.0002) following FMT treatment. No significant adverse events were reported.
Conclusions
These preliminary results suggest that FMT is a safe and potentially effective therapeutic approach for managing severe CID in the CRC patient population.
{"title":"Assessing the Safety and Efficacy of Fecal Microbiota Transplantation for Severe Chemotherapy-Induced Diarrhea in Colorectal Cancer Patients: A Single-Arm Clinical Trial","authors":"Mohammed Alnaggar, Mueataz A. Mahyoub, Wen Cheng, Weiwei Huang, Yalin Xu, Shengzhou Wang, Ting Chen, Jamal Alshorman","doi":"10.1155/ijcp/8052716","DOIUrl":"https://doi.org/10.1155/ijcp/8052716","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Diarrhea constitutes a significant complication among colorectal cancer (CRC) patients undergoing cytotoxic chemotherapy, impacting both their quality of life and treatment adherence. We aimed to assess the safety and efficacy of fecal microbiota transplantation (FMT) in severe chemotherapy-induced diarrhea (CID) among patients with CRC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We conducted an open-label, single-arm trial involving 20 patients with CRC experiencing severe CID (grade 2 or 3) as defined by the Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0, in whom conventional standard antidiarrheal treatments were ineffective. Patients received a single course of orally administered FMT capsules, with a protocol allowing for a repeat course at a 2-week interval if needed. Each course consisted of 90 capsules (10 capsules three times daily on Days 1, 2, and 3), delivering approximately 180 × 10<sup>10</sup> colony-forming units (CFU) of bacteria. Patients were monitored for 12 weeks. The primary endpoint was the proportion of patients achieving a sustained clinical response (diarrhea reduced to less than six unformed bowel movements per day). Secondary endpoints included changes in gut microbiome composition and immune cell populations. Genomic analysis (16S rRNA gene sequencing) and immune cell phenotyping (flow cytometry) were performed on samples collected before and after FMT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall response rate, characterized by the improvement of diarrhea to less than six unformed bowel movements per day following one or more FMT procedures over a minimum period of 12 weeks, was noted in 85% (17/20) of patients (95% confidence interval [CI], [62.1%, 96.8%]). Genomic analysis demonstrated significant improvements in gut microbiome diversity after FMT. Moreover, it revealed significant alterations in immune cell populations post-FMT. Specifically, we observed a statistically significant increase in CD19+ B cells (<i>p</i> = 0.0001), CD3+ CD8+ T cytotoxic cells (<i>p</i> = 0.0010), and natural killer (NK) cells (<i>p</i> = 0.0002) following FMT treatment. No significant adverse events were reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These preliminary results suggest that FMT is a safe and potentially effective therapeutic approach for managing severe CID in the CRC patient population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/8052716","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div> <section> <h3> Background</h3> <p>Given the high recurrence rate of kidney stone disease (KSD), surgical interventions alone are not an optimal solution. Antibody-mediated immune responses and mitochondrial dysfunction influence the risk and prognosis of KSD; however, the exact causal mechanisms underlying these relationships remain unclear. Investigating these causal relationships is crucial for improving treatment and prevention strategies.</p> </section> <section> <h3> Methods</h3> <p>This study utilized summary-level genome-wide association study data to perform a two-sample Mendelian randomization (MR) analysis. A total of 46 antibody-mediated immune responses from 13 pathogens and mitochondrial DNA copy number (mtDNA-CN), an indicator of mitochondrial function, were analyzed in KSD. Causal effects were estimated with up to 10 MR methods, primarily inverse-variance weighting (IVW) and the Wald ratio. Sensitivity analyses, including assessments of pleiotropy, heterogeneity, and leave-one-out analysis, were supplemented by causal analysis using summary effect estimates (CAUSE) to ensure robust results.</p> </section> <section> <h3> Results</h3> <p>After false discovery rate (FDR) correction, significant causal associations were observed between genetically predicted antihuman herpesvirus 6 (HHV-6) IgG seropositivity (odds ratio [OR] = 1.481, 95% confidence interval (CI) 1.133–1.935, <i>p</i> = 4.01 × 10<sup>−3</sup>, <i>P</i><sub><i>F</i><i>D</i><i>R</i></sub> = 0.047) and HHV-6 IE1B antibody levels (OR = 2.024, 95% CI 1.455–2.817, <i>p</i> = 2.87 × 10<sup>−5</sup>, <i>P</i><sub><i>F</i><i>D</i><i>R</i></sub> = 6.74 × 10<sup>−4</sup>) with increased KSD risk, as well as <i>Chlamydia trachomatis</i> tarp-D F2 antibody levels (OR = 0.912, 95% CI 0.861–0.966, <i>p</i> = 1.58 × 10<sup>−3</sup>, <i>P</i><sub><i>F</i><i>D</i><i>R</i></sub> = 0.025) and human herpesvirus 7 (HHV-7) U14 antibody levels (OR = 0.694, 95% CI 0.593–0.813, <i>p</i> = 5.96 × 10<sup>−6</sup>, <i>P</i><sub><i>F</i><i>D</i><i>R</i></sub> = 2.80 × 10<sup>−4</sup>) with reduced KSD risk. Additionally, suggestive evidence was identified for three other antibody-mediated immune responses. Reverse analysis indicated a potential causal relationship between KSD and lower mtDNA-CN levels (<i>β</i> = −0.012, 95% CI −0.024 to −0.0002, <i>p</i> = 0.045, <i>P</i><sub><i>F</i><i>D</i><i>R</i></sub> = 0.539). Multiple sensitivity analyses confirmed the robustness of these findings.</p> </section> <section> <h3> Conclusion</h3> <p>This study demonstrates causal links between specific immune responses,
背景考虑到肾结石疾病（KSD）的高复发率，单纯的手术干预并不是最佳的解决方案。抗体介导的免疫反应和线粒体功能障碍影响KSD的风险和预后然而，这些关系背后的确切因果机制尚不清楚。调查这些因果关系对于改善治疗和预防策略至关重要。方法本研究利用汇总水平的全基因组关联研究数据进行双样本孟德尔随机化（MR）分析。分析了13种病原菌46种抗体介导的免疫应答和线粒体DNA拷贝数（mtDNA-CN）（线粒体功能指标）。因果效应估计有多达10个MR方法，主要是反方差加权（IVW）和沃尔德比。敏感性分析，包括评估多效性、异质性和遗漏分析，辅以因果分析，使用总结效应估计（CAUSE）来确保可靠的结果。结果经错误发现率（FDR）校正后，基因预测抗人疱疹病毒6 (HHV-6) IgG血清阳性（比值比[OR] = 1.481, 95%可信区间（CI） 1.133-1.935, p = 4.01 × 10−3,PFDR = 0.047）和HHV-6 IE1B抗体水平（OR = 2.024, 95% CI 1.455-2.817, p = 2.87 × 10−5,PFDR = 6.74 × 10−4）与KSD风险增加存在显著的因果关系。沙眼衣原体tarp-D F2抗体水平（OR = 0.912, 95% CI 0.861-0.966, p = 1.58 × 10−3,PFDR = 0.025）和人疱疹病毒7 (HHV-7) U14抗体水平（OR = 0.694, 95% CI 0.593-0.813, p = 5.96 × 10−6,PFDR = 2.80 × 10−4）与KSD风险降低有关。此外，还发现了其他三种抗体介导的免疫反应的暗示性证据。反向分析表明，KSD与mtDNA-CN水平降低之间存在潜在的因果关系（β = - 0.012, 95% CI = - 0.024 ~ - 0.0002, p = 0.045, PFDR = 0.539）。多重敏感性分析证实了这些发现的稳健性。结论本研究表明特异性免疫应答、mtDNA-CN和KSD之间存在因果关系，强调了免疫调节和线粒体功能障碍的作用。这些发现为预防和个性化治疗提供了新的目标。
{"title":"Exploring the Causal Relationship Between Mitochondrial DNA Copy Number, Antibody-Mediated Immune Response, and Risk of Kidney Stone Disease: A Mendelian Randomization Study","authors":"Wenqiong Chen, Yan Qian","doi":"10.1155/ijcp/7114145","DOIUrl":"https://doi.org/10.1155/ijcp/7114145","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Given the high recurrence rate of kidney stone disease (KSD), surgical interventions alone are not an optimal solution. Antibody-mediated immune responses and mitochondrial dysfunction influence the risk and prognosis of KSD; however, the exact causal mechanisms underlying these relationships remain unclear. Investigating these causal relationships is crucial for improving treatment and prevention strategies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study utilized summary-level genome-wide association study data to perform a two-sample Mendelian randomization (MR) analysis. A total of 46 antibody-mediated immune responses from 13 pathogens and mitochondrial DNA copy number (mtDNA-CN), an indicator of mitochondrial function, were analyzed in KSD. Causal effects were estimated with up to 10 MR methods, primarily inverse-variance weighting (IVW) and the Wald ratio. Sensitivity analyses, including assessments of pleiotropy, heterogeneity, and leave-one-out analysis, were supplemented by causal analysis using summary effect estimates (CAUSE) to ensure robust results.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After false discovery rate (FDR) correction, significant causal associations were observed between genetically predicted antihuman herpesvirus 6 (HHV-6) IgG seropositivity (odds ratio [OR] = 1.481, 95% confidence interval (CI) 1.133–1.935, <i>p</i> = 4.01 × 10<sup>−3</sup>, <i>P</i><sub><i>F</i><i>D</i><i>R</i></sub> = 0.047) and HHV-6 IE1B antibody levels (OR = 2.024, 95% CI 1.455–2.817, <i>p</i> = 2.87 × 10<sup>−5</sup>, <i>P</i><sub><i>F</i><i>D</i><i>R</i></sub> = 6.74 × 10<sup>−4</sup>) with increased KSD risk, as well as <i>Chlamydia trachomatis</i> tarp-D F2 antibody levels (OR = 0.912, 95% CI 0.861–0.966, <i>p</i> = 1.58 × 10<sup>−3</sup>, <i>P</i><sub><i>F</i><i>D</i><i>R</i></sub> = 0.025) and human herpesvirus 7 (HHV-7) U14 antibody levels (OR = 0.694, 95% CI 0.593–0.813, <i>p</i> = 5.96 × 10<sup>−6</sup>, <i>P</i><sub><i>F</i><i>D</i><i>R</i></sub> = 2.80 × 10<sup>−4</sup>) with reduced KSD risk. Additionally, suggestive evidence was identified for three other antibody-mediated immune responses. Reverse analysis indicated a potential causal relationship between KSD and lower mtDNA-CN levels (<i>β</i> = −0.012, 95% CI −0.024 to −0.0002, <i>p</i> = 0.045, <i>P</i><sub><i>F</i><i>D</i><i>R</i></sub> = 0.539). Multiple sensitivity analyses confirmed the robustness of these findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study demonstrates causal links between specific immune responses,","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/7114145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenqiang Guo, Shifeng Guo, Kang Yang, Hua Huang, Jia Chen, Zhihui Huang, Qing Hong, Leizhen Xia, Jialv Huang, Tao Luo, Lin Xu, Houyang Chen
Background
Congenital bilateral absence of the vas deferens (CBAVD) is one of the causes of male infertility.
Objective
The study aims to analyze the genetic screening results and assisted reproductive outcomes of CBAVD patients, providing a reference for improving the genetic mutation profile and assisted reproductive outcomes in the Chinese population.
Methods
CFTR and ADGRG2 genes were screened and sequenced in 26 CBAVD patients using high-throughput sequencing to summarize and assess assisted reproduction outcomes.
Results
Among the 26 CBAVD patients, 76.9% (20/26) had one or more reportable CFTR mutations. In addition to the IVS9-5T mutation, 23 different CFTR mutations were detected in these 26 patients, with 6 mutations found to be harmful through bioinformatics analysis. No new CFTR mutations or ADGRG2 mutations were found. The sperm of all 26 patients was obtained through surgical procedures, with a fertilization rate of 74.9%, cleavage rate of 92.8%, available embryo rate of 55.1%, high-quality embryo rate of 22.4%, implantation rate of 36.7%, clinical pregnancy rate of 47.1%, and live birth rate of 32.3%.
Conclusions
CBAVD patients can reproduce offspring through assisted reproductive techniques, and no statistically significant differences in assisted reproduction outcomes were found in patients with CBAVD with or without reportable CFTR mutations.
{"title":"Genetic Analysis and Assisted Reproductive Outcomes in Patients With CBAVD in China: A Retrospective Study","authors":"Wenqiang Guo, Shifeng Guo, Kang Yang, Hua Huang, Jia Chen, Zhihui Huang, Qing Hong, Leizhen Xia, Jialv Huang, Tao Luo, Lin Xu, Houyang Chen","doi":"10.1155/ijcp/9919699","DOIUrl":"https://doi.org/10.1155/ijcp/9919699","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Congenital bilateral absence of the vas deferens (CBAVD) is one of the causes of male infertility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The study aims to analyze the genetic screening results and assisted reproductive outcomes of CBAVD patients, providing a reference for improving the genetic mutation profile and assisted reproductive outcomes in the Chinese population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>CFTR and ADGRG2 genes were screened and sequenced in 26 CBAVD patients using high-throughput sequencing to summarize and assess assisted reproduction outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 26 CBAVD patients, 76.9% (20/26) had one or more reportable CFTR mutations. In addition to the IVS9-5T mutation, 23 different CFTR mutations were detected in these 26 patients, with 6 mutations found to be harmful through bioinformatics analysis. No new CFTR mutations or ADGRG2 mutations were found. The sperm of all 26 patients was obtained through surgical procedures, with a fertilization rate of 74.9%, cleavage rate of 92.8%, available embryo rate of 55.1%, high-quality embryo rate of 22.4%, implantation rate of 36.7%, clinical pregnancy rate of 47.1%, and live birth rate of 32.3%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>CBAVD patients can reproduce offspring through assisted reproductive techniques, and no statistically significant differences in assisted reproduction outcomes were found in patients with CBAVD with or without reportable CFTR mutations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":13782,"journal":{"name":"International Journal of Clinical Practice","volume":"2025 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ijcp/9919699","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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