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Materials modelling in the University of Limpopo. 林波波大学的材料建模。
IF 3.6 3区 生物学 Q1 BIOLOGY Pub Date : 2024-08-09 eCollection Date: 2024-08-01 DOI: 10.1098/rsfs.2024.0005
Phuti E Ngoepe, Alan V Chadwick, Happy M Sithole, Khotso D K Mokhele, C Richard A Catlow

This article provides insights into building research capacity in computational modelling of materials at the University of Limpopo (UL), formerly University of the North, in South Africa, through a collaboration with a consortium of universities in the United Kingdom (UK) through the support of the National Research Foundation (NRF), formerly the Foundation for Research and Development, and the Royal Society (RS). A background that led to the choice of building research capacity at historically disadvantaged universities in South Africa, including the UL, is given. The modus operandi of the collaboration between the UL and several UK universities on computational modelling of materials is outlined, together with the scientific highlights that were achieved in themes of minerals, energy storage and alloy development. The capacity built in terms of human capital and institutions set up is shared, which is followed by a discussion of the continuing research activities after the formal NRF-RS collaboration ceased with more alignment to industrial applications with national and international support. We conclude by highlighting the success of the project in capacity-building and consolidating the Materials Modelling Centre with developments of high-performance computing in South Africa and the African continent. We comment on the lessons learned regarding successful capacity-building programmes.

本文介绍了南非林波波大学(UL)(前身为北方大学)在国家研究基金会(NRF)(前身为研究与发展基金会)和英国皇家学会(RS)的支持下,通过与英国大学联盟合作,在材料计算建模方面开展研究能力建设的情况。本文介绍了选择在历史上处于不利地位的南非大学(包括 UL)开展研究能力建设的背景。概述了 UL 与英国几所大学在材料计算建模方面的合作模式,以及在矿物、能源储存和合金开发等主题方面取得的科学成果。我们还分享了在人力资本和机构建立方面的能力建设情况,随后讨论了在国家研究基金与英国皇家科学院的正式合作停止后继续开展的研究活动,以及在国家和国际支持下更多地与工业应用相结合的情况。最后,我们强调了该项目在能力建设和巩固材料建模中心方面取得的成功,以及南非和非洲大陆高性能计算的发展。我们对成功的能力建设计划的经验教训进行了评论。
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引用次数: 0
Exploring the West African forest island phenomenon: scientific insights gained, successes achieved and capacities strengthened 探索西非森林岛屿现象:获得的科学见解、取得的成功和加强的能力
IF 3.6 3区 生物学 Q1 BIOLOGY Pub Date : 2024-08-09 DOI: 10.1098/rsfs.2023.0078
Vincent Logah, J. Azeez, H. Compaore, S. Mesele, C. M. Ocansey, A. Bougma, E. N. Tetteh, E. Veenendaal, Jonathan Lloyd
Anthropogenic activities around local villages in mesic savanna landscapes of West Africa have resulted in soil improvement and forest establishment outside their climatic zones. Such unique ‘forest islands’ have been reported to provide ecosystem services including biodiversity conservation. However, the science underpinning their formations is limitedly studied. In 2015 and with funding support from the Royal Society-DFID (now FCDO), we set out to investigate the biogeochemistry of the forest islands in comparison with adjacent natural savanna and farmlands across 11 locations in Burkina Faso, Ghana and Nigeria. Our results showed that the forest islands do not differ significantly from the adjoining ecosystems in soil mineralogy implying that their formation was anthropogenically driven. We observed greater soil organic carbon and nutrient distributions in the forest islands, which also had more stable macro (>500 μm) and meso-aggregates (500–250 μm) than the adjoining agricultural lands. We found that soil micro-aggregate (250–53 μm) stability was climate (precipitation) driven in the West African ecosystems while meso- and macro-aggregate stability was land-use driven. In one of the unique forest islands we studied in the Mole National Park of Ghana, we found its mineral-associated organic carbon over 40% greater than the adjoining natural savanna with potential implications for the achievement of the global initiative of the ‘4p1000’ in West Africa. We conclude that the North–South–South research collaboration has established clearly, the science underlying the age-long West African forest island phenomenon and has, among many successes, led to capacity building of young scientists driving cutting-edge research in climate change adaptation and food systems transformation in the sub-region.
西非中生热带稀树草原景观中当地村庄周围的人为活动导致了土壤改良和在其气候带之外建立森林。据报道,这些独特的 "森林岛 "可提供生态系统服务,包括生物多样性保护。然而,对其形成的科学依据研究有限。2015 年,在英国皇家学会-DFID(现为 FCDO)的资助下,我们着手调查森林岛屿的生物地球化学,并与布基纳法索、加纳和尼日利亚 11 个地点的邻近天然热带草原和农田进行比较。我们的研究结果表明,森林岛屿与邻近生态系统在土壤矿物学方面没有明显差异,这意味着森林岛屿的形成是人为因素造成的。我们观察到,森林岛屿的土壤有机碳和养分分布更为均匀,与毗邻的农田相比,森林岛屿的大颗粒(>500 μm)和中颗粒(500-250 μm)也更为稳定。我们发现,在西非生态系统中,土壤微团聚体(250-53 μm)的稳定性是由气候(降水)驱动的,而中团聚体和大团聚体的稳定性则是由土地利用驱动的。我们在加纳莫尔国家公园研究了一个独特的森林岛屿,发现其矿物质相关有机碳比毗邻的天然热带稀树草原高出 40%以上,这对在西非实现 "4p1000 "全球倡议具有潜在影响。我们的结论是,北-南-南研究合作已明确确立了西非森林岛屿现象的科学基础,并取得了许多成功,其中包括青年科学家的能力建设,推动了该次区域适应气候变化和粮食系统转型方面的前沿研究。
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引用次数: 1
RS-DFID Africa capacity-building initiative programme grant: harnessing unsteady phase-change heat exchange in high-performance concentrated solar power systems. RS-DFID 非洲能力建设倡议计划赠款:在高性能聚光太阳能发电系统中利用非稳态相变热交换。
IF 3.6 3区 生物学 Q1 BIOLOGY Pub Date : 2024-08-09 eCollection Date: 2024-08-01 DOI: 10.1098/rsfs.2023.0059
Benedict Winchester, Abdullah M Maghrabi, Christos N Markides

The Royal Society and UK Department for International Development supported a consortium of three universities across sub-Saharan Africa and Imperial College London with the aim of developing new knowledge on direct-steam-generation concentrated solar power (CSP) plants and supporting relevant capacity building across the Universities of Lagos, Mauritius and Pretoria. Key research findings from the programme include an improved flow-classification scheme for two-phase, liquid-liquid flows; testing of advanced surfaces with much-improved steady-state heat transfer performance-the commercial nanoFLUX surface showed up to 200% higher heat-transfer coefficients (HTCs) in pool boiling compared with other surfaces with R-134a/R-245fa; first-of-a-kind measurements of transient flow boiling HTCs, which were up to 30% lower in step perturbations than quasi-steady-state expectations in horizontal pipes with R-245fa; error estimation and corrections for laser-induced fluorescence (LIF) measurements, leading to the development of an adapted planar LIF technique with uncertainty <10% for local, instantaneous film thickness measurements in annular flows, and the application of such diagnostic methods to pool, falling-film and flow boiling in pipes; and predictions of an ~80% increase in the net present value of a case-study CSP plant when integrated with solid storage media.

英国皇家学会和英国国际发展部为撒哈拉以南非洲地区的三所大学和伦敦帝国理工学院组成的联合体提供支持,旨在开发有关直接蒸汽发电聚光太阳能(CSP)电站的新知识,并支持拉各斯大学、毛里求斯大学和比勒陀利亚大学的相关能力建设。该计划的主要研究成果包括:改进了液-液两相流的流动分类方案;测试了稳态传热性能大为改善的先进表面--商用纳米FLUX 表面在池沸腾时的传热系数(HTCs)比使用 R-134a/R-245fa 的其他表面高出 200%;首次测量瞬态流动沸腾的 HTCs,在使用 R-245fa 的水平管道中,阶跃扰动比准稳态预期值低 30%;对激光诱导荧光(LIF)测量进行误差估计和修正,从而开发出一种具有不确定性的改良平面 LIF 技术。
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引用次数: 0
Creating sustainable capacity for river science in the Congo basin through the CRuHM project. 通过 CRuHM 项目,在刚果盆地创建河流科学的可持续能力。
IF 3.6 3区 生物学 Q1 BIOLOGY Pub Date : 2024-08-09 eCollection Date: 2024-08-01 DOI: 10.1098/rsfs.2023.0079
Paul D Bates, Raphaël M Tshimanga, Mark A Trigg, Andy Carr, C A Mushi, Pierre M Kabuya, Gode Bola, Jeff Neal, Preksedis Nbomba, Felix Mtalo, Denis Hughes

In this article, we examine the scientific and sustainable research capacity outcomes of the 'Congo River: user Hydraulics and Morphology' or CRuHM project, a six-year effort supported by the Royal Society's Africa Capacity Building Initiative. This project brought together a consortium of African and UK universities to undertake the first large-scale scientific expeditions to the Congo basin of the modern era in order to better understand the hydraulics and geomorphology of this understudied but globally important river. The river is essential for navigation, irrigation, drinking water and hydroelectric power generation for the 10 basin countries and is critically important for biodiversity and global nutrient, carbon and climatological cycles. This article summarizes the new scientific understanding contributed by the project and the steps taken to ensure a meaningful legacy that would continue long beyond the finite lifetime of available funding. Actions taken to achieve this include establishing a new hydrology research centre at the University of Kinshasa as well as steps to build a wider international community of Congo basin researchers. In this way, we hope to build momentum for future funding initiatives and collaboration.

在这篇文章中,我们探讨了 "刚果河:用户水力学和形态学"(CRuHM)项目的科学和可持续研究能力成果,该项目由英国皇家学会非洲能力建设计划支持,历时六年。该项目汇集了非洲和英国的多所大学,对刚果河流域进行了现代首次大规模科学考察,以更好地了解这条研究不足但具有全球重要性的河流的水力学和地貌学。该河流对流域内 10 个国家的航运、灌溉、饮用水和水力发电至关重要,对生物多样性以及全球养分、碳和气候循环也极为重要。这篇文章总结了该项目带来的新的科学认识,以及为确保在有限的可用资金使用期限之后仍能继续留下有意义的遗产而采取的措施。为实现这一目标而采取的行动包括在金沙萨大学建立一个新的水文研究中心,以及采取措施建立一个更广泛的刚果盆地研究人员国际社区。我们希望通过这种方式,为今后的资助活动和合作造势。
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引用次数: 0
Capacity building in porous materials research for sustainable energy applications. 多孔材料研究能力建设,促进可持续能源应用。
IF 3.6 3区 生物学 Q1 BIOLOGY Pub Date : 2024-08-09 eCollection Date: 2024-08-01 DOI: 10.1098/rsfs.2023.0067
Henrietta W Langmi, Nicholas M Musyoka, Justin C Kemmegne-Mbouguen, Chrispin Kowenje, Fredrick Kengara, Robert Mokaya

The project aimed to develop porous materials for sustainable energy applications, namely, hydrogen storage, and valorization of biomass to renewable fuels. At the core of the project was a training programme for Africa-based researchers in (i) the exploitation of renewable locally available raw materials; (ii) the use of advanced state-of-the-art techniques for the design and synthesis of porous materials (zeolites and metal-organic frameworks (MOFs)) for energy storage; and (iii) the valorization of sustainable low-value feedstock to renewable fuels. We found that compaction of the UiO-66 MOF at high pressure improves volumetric hydrogen storage capacity without any loss in gravimetric uptake, and experimentally demonstrated the temperature-dependent dynamic behaviour of UiO-66, which allowed us to propose an activation temperature of ≤ 150°C for UiO-66. Co-pelletization was used to fabricate UiO-66/nanofibre monoliths as hierarchical porous materials with enhanced usable (i.e. deliverable) hydrogen storage capacity. We clarified the use of naturally occurring kaolin as a source of silica and alumina species for zeolite synthesis. The kaolin-derived zeolite X was successfully used as a catalyst for the transesterification of Jatropha curcas oil (from non-edible biomass) to biodiesel. We also prepared porous composites (i.e. carbon/UiO-66, organoclay/UiO-66 and zeolite/carbon) that were successfully applied in electrochemical sensing.

该项目旨在为可持续能源应用开发多孔材料,即氢储存和生物质转化为可再生燃料。该项目的核心是为非洲的研究人员提供以下方面的培训计划:(i) 利用当地可再生原材料;(ii) 利用先进技术设计和合成用于储能的多孔材料(沸石和金属有机框架(MOFs));(iii) 将可持续的低价值原料转化为可再生燃料。我们发现,在高压下压实 UiO-66 MOF 可提高体积储氢能力,而重力吸收能力不会有任何损失,并通过实验证明了 UiO-66 的动态行为与温度有关,这使我们能够提出 UiO-66 的活化温度为 ≤ 150°C。我们利用共造粒技术制造出了 UiO-66/ 纳米纤维单片,这种分层多孔材料具有更强的可用(即可输送)储氢能力。我们阐明了如何利用天然高岭土作为沸石合成的二氧化硅和氧化铝来源。高岭土衍生的沸石 X 被成功用作麻风树油(来自非食用生物质)酯交换转化为生物柴油的催化剂。我们还制备了多孔复合材料(即碳/UiO-66、有机土/UiO-66 和沸石/碳),并将其成功应用于电化学传感。
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引用次数: 0
Chem4Energy: a consortium of the Royal Society Africa Capacity-Building Initiative. Chem4Energy:英国皇家学会非洲能力建设计划联合体。
IF 3.6 3区 生物学 Q1 BIOLOGY Pub Date : 2024-08-09 eCollection Date: 2024-08-01 DOI: 10.1098/rsfs.2024.0001
Marietjie J Ungerer, Evans Adei, Theopolina Amakali, Cecil H Botchway, Likius S Daniel, James Darkwa, Nelson Y Dzade, Foster Mbaiwa, Mary Mensah, Maipelo Nyepetsi, Banothile Makhubela, Claire E Mitchell, Oluwasegun Emmanuel Olaoye, Olayinka A Oyetunji, Meenakshisundaram Sankar, Fortunate P Sejie, Jacobina Sheehama, Richard Tia, Veikko Uahengo, Aleksandar Živković, Nora H De Leeuw

The Africa Capacity-Building Initiative is a Royal Society programme funded by the former UK Department for International Development to develop collaborative research between scientists in sub-Saharan Africa and the UK. Initially, four institutions were involved in the Chem4Energy consortium: Cardiff University in the UK and three African partners, the Kwame Nkrumah University of Science and Technology, Ghana, the University of Namibia and the University of Botswana, soon also including the Botswana International University of Science and Technology. The Chem4Energy research programme focused on 'New materials for a sustainable energy future: linking computation with experiment', aiming to deploy the synergy between state-of-the-art computational and experimental techniques to design and optimize new catalysts and semiconductor materials for renewable energy applications, based on materials that are abundant and readily available in African countries. The Chem4Energy consortium has achieved ambitious research goals, graduated seven PhD students and delivered a high-quality cross-disciplinary training programme in materials science and simulation techniques relevant to renewable energy applications. Since 2021, the extended consortium, including North-West University and the Centre for High-Performance Computing in South Africa, has remained active through an annual Chem4Energy conference series, with the sixth meeting taking place in Namibia in April 2025.

非洲能力建设计划是英国皇家学会的一项计划,由前英国国际发展部资助,旨在发展撒哈拉以南非洲和英国科学家之间的合作研究。最初,有四家机构参与了 "化学4能源 "联盟:英国卡迪夫大学和三个非洲合作伙伴:加纳夸梅-恩克鲁玛科技大学、纳米比亚大学和博茨瓦纳大学,不久还包括博茨瓦纳国际科技大学。Chem4Energy 研究计划的重点是 "面向可持续能源未来的新材料:将计算与实验相结合",旨在利用最先进的计算和实验技术之间的协同作用,以非洲国家丰富且易于获得的材料为基础,设计和优化用于可再生能源应用的新型催化剂和半导体材料。Chem4Energy 联合体已经实现了雄心勃勃的研究目标,培养了七名博士生,并在与可再生能源应用相关的材料科学和模拟技术方面开展了高质量的跨学科培训计划。自 2021 年以来,包括西北大学和南非高性能计算中心在内的扩展联盟一直通过年度 Chem4Energy 系列会议保持活跃,第六次会议将于 2025 年 4 月在纳米比亚举行。
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引用次数: 0
Doctoral training to support sustainable soil geochemistry research in Africa. 博士培训,支持非洲可持续的土壤地球化学研究。
IF 3.6 3区 生物学 Q1 BIOLOGY Pub Date : 2024-08-09 eCollection Date: 2024-08-01 DOI: 10.1098/rsfs.2023.0058
M G Manzeke-Kangara, I S Ligowe, B Kaninga, P Nalivata, V Kabambe, E Mbewe, B H Chishala, G M Sakala, P Mapfumo, F Mtambanengwe, T Tendayi, A Murwira, A D C Chilimba, F P Phiri, E L Ander, E H Bailey, R M Lark, K Millar, M J Watts, S D Young, M R Broadley

Africa's potential for scientific research is not yet being realized, for various reasons including a lack of researchers in many fields and insufficient funding. Strengthened research capacity through doctoral training programmes in higher education institutes (HEIs) in Africa, to include collaboration with national, regional and international research institutions, can facilitate self-reliant and sustainable research to support socio-economic development. In 2012, the Royal Society and the UK's Department for International Development (now the Foreign, Commonwealth and Development Office) launched the Africa Capacity Building Initiative (ACBI) Doctoral Training Network which aimed to strengthen research capacity and training across sub-Saharan Africa. The ACBI supported 30 core PhD scholarships, all registered/supervised within African HEIs with advisory support from the UK-based institutes. Our 'Soil geochemistry to inform agriculture and health policies' consortium project, which was part of the ACBI doctoral training programme network, was implemented in Malawi, Zambia and Zimbabwe between 2014 and 2020. The aims of our consortium were to explore linkages between soil geochemistry, agriculture and public health for increased crop productivity, nutrition and safety of food systems and support wider training and research activities in soil science. Highlights from our consortium included: (i) the generation of new scientific evidence on linkages between soils, crops and human nutrition; (ii) securing new projects to translate science into policy and practice; and (iii) maintaining sustainable collaborative learning across the consortium. Our consortium delivered high-quality science outputs and secured new research and doctoral training funding from a variety of sources to ensure the continuation of research and training activities. For example, follow-on Global Challenges Research Funded Translation Award provided a strong evidence base on the prevalence of deficiencies in children under 5 years of age and women of reproductive age in Zimbabwe. This new evidence will contribute towards the design and implementation of a nationally representative micronutrient survey as an integral part of the Zimbabwe Demographic and Health Surveys conducted by the Ministry of Health and Child Care. The award also generated new evidence and a road map for creating quality innovative doctorates through a doctoral training landscape activity led by the Zimbabwe Council for Higher Education. Although our project and the wider ACBI has contributed to increasing the self-reliance and sustainability of research within the region, many challenges remain and ongoing investment is required.

由于许多领域缺乏研究人员和资金不足等各种原因,非洲的科研潜力尚未得到发挥。通过在非洲高等教育机构(HEIs)开展博士生培训计划来加强研究能力,包括与国家、地区和国际研究机构开展合作,可以促进自力更生和可持续的研究,从而支持社会经济发展。2012 年,英国皇家学会和英国国际发展部(现为外交、联邦和发展办公室)启动了非洲能力建设倡议(ACBI)博士培训网络,旨在加强撒哈拉以南非洲地区的研究能力和培训。非洲能力建设倡议为 30 个核心博士奖学金项目提供了支持,这些项目均在非洲高等院校注册/接受指导,并由英国研究所提供咨询支持。我们的 "土壤地球化学为农业和卫生政策提供信息 "联合项目是 ACBI 博士培训计划网络的一部分,于 2014 年至 2020 年期间在马拉维、赞比亚和津巴布韦实施。该联合项目旨在探索土壤地球化学、农业和公共卫生之间的联系,以提高作物产量、营养和食品系统安全,并支持更广泛的土壤科学培训和研究活动。我们的合作项目重点包括(i) 就土壤、作物和人类营养之间的联系提出了新的科学证据;(ii) 确保开展新项目,将科学转化为政策和实践;(iii) 保持整个联盟的可持续合作学习。我们的联盟提供了高质量的科学成果,并从各种来源获得了新的研究和博士培训资金,以确保研究和培训活动的继续。例如,"全球挑战研究资助转化奖 "后续项目为津巴布韦 5 岁以下儿童和育龄妇女普遍缺乏营养提供了强有力的证据基础。这一新证据将有助于设计和实施一项具有全国代表性的微营养素调查,作为卫生和儿童保育部开展的津巴布韦人口与健康调查的一个组成部分。该奖项还提供了新的证据和路线图,以便通过津巴布韦高等教育委员会领导的博士培训景观活动,创建高质量的创新型博士学位。尽管我们的项目和更广泛的 ACBI 为提高该地区研究的自立性和可持续性做出了贡献,但许多挑战依然存在,需要持续投资。
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引用次数: 0
Portrait of a UK-Africa Capacity Building Initiative Consortium 2015-2022: the Cameroon, Ghana, South Africa and United Kingdom Materials Initiative (CaGSUMI) for developing materials for solar cells. 2015-2022 年英国-非洲能力建设倡议联盟简介:喀麦隆、加纳、南非和英国材料倡议 (CaGSUMI),用于开发太阳能电池材料。
IF 3.6 3区 生物学 Q1 BIOLOGY Pub Date : 2024-08-09 eCollection Date: 2024-08-01 DOI: 10.1098/rsfs.2023.0057
Peter T Ndifon, Johannes Awudza, Neerish Revaprasadu, Paul O'Brien, David J Lewis

The CaGSUMI consortium was funded by the Royal Society-Department for International Development (later the Foreign, Commonwealth & Development Office) on the Africa Capacity Building Initiative programme between the years 2015 and 2022 and involved three Sub-Saharan African universities: Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, University of Yaoundé I, Cameroon, and the University of Zululand, South Africa; and the University of Manchester in the United Kingdom. The project was used to cement an emergent UK-Africa network in the areas of materials chemistry related to renewable energy generation with both thin films and nanomaterials. The consortium's outputs led to numerous publications of African science in international journals, a number of graduated PhDs who went on to permanent academic positions and prestigious fellowships, the establishment of a capacity-building plan relevant to the chemistry departments in each of the African countries, and the installation of a number of first-in-kind pieces of kit for African laboratories that will keep them on a competitive footing at an international level for the next decade and more.

CaGSUMI 联合体由英国皇家学会-国际发展部(后为外交、英联邦和发展办公室)在 2015 年至 2022 年间的非洲能力建设倡议计划资助,涉及三所撒哈拉以南非洲大学:加纳库马西夸梅-恩克鲁玛科技大学、喀麦隆雅温得第一大学、南非祖鲁兰大学以及英国曼彻斯特大学参与了该项目。该项目被用来巩固英国与非洲在与利用薄膜和纳米材料生产可再生能源有关的材料化学领域的新兴网络。该联合会的成果包括:在国际期刊上发表了大量非洲科学论文;一些博士毕业生获得了长期学术职位和著名的奖学金;制定了一项与每个非洲国家化学系相关的能力建设计划;为非洲实验室安装了一些首创的工具包,这些工具包将使这些实验室在未来十年甚至更长的时间里保持国际竞争力。
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引用次数: 0
Effects of mineralization on the hierarchical organization of collagen—a synchrotron X-ray scattering and polarized second harmonic generation study 矿化对胶原分层组织的影响--同步辐射 X 射线散射和偏振二次谐波发生研究
IF 4.4 3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-06-01 DOI: 10.1098/rsfs.2023.0046
Keke Zheng, Jingxiao Zhong, Jingrui Hu, Eve Nebbiolo, Juan Sanchez-Weatherby, Tengteng Tang, William J. Landis, Junning Chen, Peter Winlove, Benjamin E. Sherlock, James Bell
The process of mineralization fundamentally alters collagenous tissue biomechanics. While the structure and organization of mineral particles have been widely studied, the impact of mineralization on collagen matrix structure, particularly at the molecular scale, requires further investigation. In this study, synchrotron X-ray scattering (XRD) and polarization-resolved second harmonic generation microscopy (pSHG) were used to study normally mineralizing turkey leg tendon in tissue zones representing different stages of mineralization. XRD data demonstrated statistically significant differences in collagen D-period, intermolecular spacing, fibril and molecular dispersion and relative supramolecular twists between non-mineralizing, early mineralizing and late mineralizing zones. pSHG analysis of the same tendon zones showed the degree of collagen fibril organization was significantly greater in early and late mineralizing zones compared to non-mineralizing zones. The combination of XRD and pSHG data provide new insights into hierarchical collagen–mineral interactions, notably concerning possible cleavage of intra- or interfibrillar bonds, occlusion and reorganization of collagen by mineral with time. The complementary application of XRD and fast, label-free and non-destructive pSHG optical measurements presents a pathway for future investigations into the dynamics of molecular scale changes in collagen in the presence of increasing mineral deposition.
矿化过程从根本上改变了胶原组织的生物力学。虽然矿物颗粒的结构和组织已被广泛研究,但矿化对胶原基质结构的影响,尤其是在分子尺度上的影响,还需要进一步研究。本研究采用同步辐射 X 射线散射 (XRD) 和偏振分辨二次谐波发生显微镜 (pSHG) 对代表不同矿化阶段的组织区域中正常矿化的火鸡腿肌腱进行了研究。XRD 数据显示,非矿化区、早期矿化区和晚期矿化区之间的胶原蛋白 D 周期、分子间距、纤维和分子分散性以及相对超分子扭曲程度存在显著的统计学差异。XRD 和 pSHG 数据的结合为分层胶原蛋白-矿物质相互作用提供了新的视角,特别是关于可能的纤维内或纤维间键的裂解、矿物质对胶原蛋白的堵塞和重组。XRD 与快速、无标记和无损 pSHG 光学测量的互补应用为未来研究矿物质沉积增加时胶原蛋白分子尺度的动态变化提供了一条途径。
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引用次数: 1
Stiff morphing composite beams inspired from fish fins 从鱼鳍中汲取灵感的刚性变形复合梁
IF 4.4 3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-06-01 DOI: 10.1098/rsfs.2023.0072
Saurabh Das, Prashant Kunjam, Baptiste Moling, Tian Gao, Francois Barthelat
Morphing materials are typically either very compliant to achieve large shape changes or very stiff but with small shape changes that require large actuation forces. Interestingly, fish fins overcome these limitations: fish fins do not contain muscles, yet they can change the shape of their fins with high precision and speed while producing large hydrodynamic forces without collapsing. Here, we present a ‘stiff’ morphing beam inspired from the individual rays in natural fish fins. These synthetic rays are made of acrylic (PMMA) outer beams (‘hemitrichs’) connected with rubber ligaments which are 3–4 orders of magnitude more compliant. Combinations of experiments and models of these synthetic rays show strong nonlinear geometrical effects: the ligaments are ‘mechanically invisible’ at small deformations, but they delay buckling and improve the stability of the ray at large deformations. We use the models and experiments to explore designs with variable ligament densities, and we generate design guidelines for optimum morphing shape (captured using the first moment of curvature), that capture the trade-offs between morphing compliance (ease of morphing the structure) and flexural stiffness. The design guidelines proposed here can help the development of stiff morphing bioinspired structures for a variety of applications in aerospace, biomedicine or robotics.
变形材料通常要么非常顺从以实现较大的形状变化,要么非常坚硬但形状变化较小,需要较大的驱动力。有趣的是,鱼鳍克服了这些限制:鱼鳍不含肌肉,但却能高精度、高速地改变鳍的形状,同时产生巨大的流体动力而不会塌陷。在这里,我们展示了一种 "坚硬 "的变形梁,其灵感来自于天然鱼鳍中的单个鱼鳍。这些合成鱼鳍由丙烯酸(PMMA)外梁("hemitrichs")和橡胶韧带连接而成,橡胶韧带的顺应性要高出 3-4 个数量级。这些合成射线的实验和模型组合显示出强烈的非线性几何效应:韧带在小变形时是 "机械隐形 "的,但在大变形时却能延迟屈曲并提高射线的稳定性。我们利用模型和实验来探索韧带密度可变的设计,并为最佳变形形状(使用第一曲率矩捕捉)生成设计指南,该指南捕捉了变形顺应性(结构变形的难易程度)和弯曲刚度之间的权衡。本文提出的设计准则有助于开发刚度变形生物启发结构,可广泛应用于航空航天、生物医学或机器人领域。
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引用次数: 2
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Interface Focus
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