Pub Date : 2023-07-30DOI: 10.22192/ijcrcps.2023.10.07.002
Nikhil Adole, Prof Prajakta Patil
Herbal shampoos are the cosmetic preparations that with the use of traditional ayurvedic herbs are meant for cleansing the hair and scalp just like the regular synthetic shampoo. The herbal shampoo was formulated by addingthe extracts of Aloe vera, Phyllanthus emblica, Acacia concinna, Withania somnifera, Aegle marmelos. They are usedfor removal of oils, dandruff, dirt, environmental pollutions etc. Herbal shampoo is a type of cosmetic preparation that uses herbs from plants as an alternative to the synthetic shampoo available in the market. The herbal shampoo isimportant, as people nowadays prefer herbal products than chemical ones for they proved to enhance health. Evaluation of the organoleptic properties, physicochemical and performance test were carried out. The resultsindicated that this can be used as a potential alternative for cleaning and managing hair in a naturaland effective wayinstead of synthetic source. The awareness and need for cosmetics with herbs are increasing day by day, primarilybecause it is believed that these products are safe and free from side effects. In this research, we use Eclipta prostrateasan active ingredient for hair growth activity. Keywords: Herbal Shampoo, Natural & Healthy, Dandruff, Aloe vera, Phyllanthus emblica, Acacia concinna, Sapindus mukorossi, Aegle marmelos, Withania somnifera, Evaluation of shampoo.
{"title":"Formulation and Evaluation of Herbal Anti - DandruffShampoo from Bhringraj leaf","authors":"Nikhil Adole, Prof Prajakta Patil","doi":"10.22192/ijcrcps.2023.10.07.002","DOIUrl":"https://doi.org/10.22192/ijcrcps.2023.10.07.002","url":null,"abstract":"Herbal shampoos are the cosmetic preparations that with the use of traditional ayurvedic herbs are meant for cleansing the hair and scalp just like the regular synthetic shampoo. The herbal shampoo was formulated by addingthe extracts of Aloe vera, Phyllanthus emblica, Acacia concinna, Withania somnifera, Aegle marmelos. They are usedfor removal of oils, dandruff, dirt, environmental pollutions etc. Herbal shampoo is a type of cosmetic preparation that uses herbs from plants as an alternative to the synthetic shampoo available in the market. The herbal shampoo isimportant, as people nowadays prefer herbal products than chemical ones for they proved to enhance health. Evaluation of the organoleptic properties, physicochemical and performance test were carried out. The resultsindicated that this can be used as a potential alternative for cleaning and managing hair in a naturaland effective wayinstead of synthetic source. The awareness and need for cosmetics with herbs are increasing day by day, primarilybecause it is believed that these products are safe and free from side effects. In this research, we use Eclipta prostrateasan active ingredient for hair growth activity. Keywords: Herbal Shampoo, Natural & Healthy, Dandruff, Aloe vera, Phyllanthus emblica, Acacia concinna, Sapindus mukorossi, Aegle marmelos, Withania somnifera, Evaluation of shampoo.","PeriodicalId":13826,"journal":{"name":"International Journal of Current Research in Chemistry and Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135397981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-26DOI: 10.22192/ijcrcps.2023.10.04.001
V. J, A. K. Dantuluri, Yi Liu, T. Durig
Pharmaceutical formulations in liquid form for oral administration are commonly utilized for geriatric and pediatricpatients who have difficulty swallowing solid dosage forms. Rheology, texture, and stability are among the Critical Quality Attributes (CQAs) that must be addressed in the development of oral liquid dosage forms. The distribution of pharmaceutical components relies on the manipulation of rheological properties and stabilization within these forms. The utilization of thickening agents to increase the viscosity of the liquid vehicle serves to reduce particle settling. Historically, sugars such as sucrose were utilized for this purpose, as well as for masking the taste of activepharmaceutical ingredients (API). However, alternative thickening agents such as xanthan gum, tragacanth, carrageenan, and cellulose derivatives (such as sodium carboxymethylcellulose, methylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose and hydroxyethylcellulose etc.) are increasingly employed asthey do not possess the same risks of glycogenic and cariogenic as sugars. Cellulose derivatives, due to their water binding and viscosity modifying properties, can be effectively utilized to enhance the rheological properties andstability of oral liquid dosage forms. The use of hydroxyethylcellulose, a highly water-soluble cellulose ether polymer, as a viscosity modifying agent, as well as its underlying polymer chemistry, is thoroughly examined in thisliterature review. Keywords: Cellulose Derivatives; hydroxyethylcellulose; oral Liquids; Natrosol™ 250 HEC, syrup
{"title":"Hydroxyethylcellulose as a versatile viscosity modifier inthe development of sugar-free, elegant oral liquidformulations","authors":"V. J, A. K. Dantuluri, Yi Liu, T. Durig","doi":"10.22192/ijcrcps.2023.10.04.001","DOIUrl":"https://doi.org/10.22192/ijcrcps.2023.10.04.001","url":null,"abstract":"Pharmaceutical formulations in liquid form for oral administration are commonly utilized for geriatric and pediatricpatients who have difficulty swallowing solid dosage forms. Rheology, texture, and stability are among the Critical Quality Attributes (CQAs) that must be addressed in the development of oral liquid dosage forms. The distribution of pharmaceutical components relies on the manipulation of rheological properties and stabilization within these forms. The utilization of thickening agents to increase the viscosity of the liquid vehicle serves to reduce particle settling. Historically, sugars such as sucrose were utilized for this purpose, as well as for masking the taste of activepharmaceutical ingredients (API). However, alternative thickening agents such as xanthan gum, tragacanth, carrageenan, and cellulose derivatives (such as sodium carboxymethylcellulose, methylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose and hydroxyethylcellulose etc.) are increasingly employed asthey do not possess the same risks of glycogenic and cariogenic as sugars. Cellulose derivatives, due to their water binding and viscosity modifying properties, can be effectively utilized to enhance the rheological properties andstability of oral liquid dosage forms. The use of hydroxyethylcellulose, a highly water-soluble cellulose ether polymer, as a viscosity modifying agent, as well as its underlying polymer chemistry, is thoroughly examined in thisliterature review. Keywords: Cellulose Derivatives; hydroxyethylcellulose; oral Liquids; Natrosol™ 250 HEC, syrup","PeriodicalId":13826,"journal":{"name":"International Journal of Current Research in Chemistry and Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78991599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-03DOI: 10.22192/ijcrcps.2021.08.09.002
Khalid A Asseri, Y. Asiri, A. Alqahtani, K. Venkatesan, Noohu Abdulla Khan, S. S. Alavudeen, E. M. Pappiya, Premalatha Paulsamy, R. Natarajan, Kalpana Krishnaraju, Kumar Venkatesan, K. Chidambaram
Diabetes mellitus patients are more prone to suffer from bone fractures. Herba Epimedii has been demonstrated to be an osteoporosis reducer in the past. However, it is yet uncertain if Herba Epimedii may protect diabetic rats from bone loss when co-administered with rosiglitazone (RSG). This study examines the impact of Herba Epimedii on bone oxidative stress and turnover markers in diabetic rats co-treated with rosiglitazone (RSG). Streptozotocin (STZ) causes diabetics. Wistar albino rats were placed into five groups, each with six rats: control (vehicle therapy), Streptozotocin (diabetes) group, Herba Epimedii group, Rosiglitazone, and Rosiglitazone +Herba Epimedii. Each medication was given by gastric gavage once a day for 35 days. Insulin, oxidative stress, and bone turnover markers were measured in the blood using ELISA assays. Insulin and osteocalcin levels were significantly higher in diabetic rats administered Herba Epimedii than in diabetic control rats. Herba Epimedii may be able to prevent diabetic osteoporosis in RSG-treated diabetic rats by enhancing osteogenesis and lowering bone oxidative stress. The utility of Herba Epimedii as an osteoporosis therapy in diabetic individuals is supported by these findings. Keywords: Herba Epimedii, Diabetes, Osteoporosis, Rosiglitazone
{"title":"Herba Epimedii extraction overcome Rosiglitazone induced bone loss in diabetic rats","authors":"Khalid A Asseri, Y. Asiri, A. Alqahtani, K. Venkatesan, Noohu Abdulla Khan, S. S. Alavudeen, E. M. Pappiya, Premalatha Paulsamy, R. Natarajan, Kalpana Krishnaraju, Kumar Venkatesan, K. Chidambaram","doi":"10.22192/ijcrcps.2021.08.09.002","DOIUrl":"https://doi.org/10.22192/ijcrcps.2021.08.09.002","url":null,"abstract":"Diabetes mellitus patients are more prone to suffer from bone fractures. Herba Epimedii has been demonstrated to be an osteoporosis reducer in the past. However, it is yet uncertain if Herba Epimedii may protect diabetic rats from bone loss when co-administered with rosiglitazone (RSG). This study examines the impact of Herba Epimedii on bone oxidative stress and turnover markers in diabetic rats co-treated with rosiglitazone (RSG). Streptozotocin (STZ) causes diabetics. Wistar albino rats were placed into five groups, each with six rats: control (vehicle therapy), Streptozotocin (diabetes) group, Herba Epimedii group, Rosiglitazone, and Rosiglitazone +Herba Epimedii. Each medication was given by gastric gavage once a day for 35 days. Insulin, oxidative stress, and bone turnover markers were measured in the blood using ELISA assays. Insulin and osteocalcin levels were significantly higher in diabetic rats administered Herba Epimedii than in diabetic control rats. Herba Epimedii may be able to prevent diabetic osteoporosis in RSG-treated diabetic rats by enhancing osteogenesis and lowering bone oxidative stress. The utility of Herba Epimedii as an osteoporosis therapy in diabetic individuals is supported by these findings. Keywords: Herba Epimedii, Diabetes, Osteoporosis, Rosiglitazone","PeriodicalId":13826,"journal":{"name":"International Journal of Current Research in Chemistry and Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86518314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-03DOI: 10.22192/ijcrcps.2021.08.09.004
A. Alqahtani, Khalid A. Asseri, Y. Asiri, K. Venkatesan, N. Khan, S. S. Alavudeen, E. M. Pappiya, Premalatha Paulsamy, R. Natarajan, Kalpana Krishnaraju, K. Venkatesan, K. Chidambaram
Osteoporosis is a condition marked by a loss of bone mass and degradation of the bone microstructure, both of which lead to increased fragility and consequent fragility fractures, particularly in the elderly. Rhizoma Drynariae (DRE) is one of the most often used herbal remedies for osteoporosis therapy. Transdermal drug administration is a well- established new method for drug delivery that offers numerous benefits over conventional routes. Wistar albino rats were split into five groups of six rats each: vehicle control, diabeticgroup, DRE group, Canagliflozin (CGF), and CGF + DRE group. Each medication was given by gastric gavage once a day for 35 days. The drug canagliflozin appears to raise the risk of fractur. When compared to the control group, DRE treatment increased bone strength at the femoral diaphysis in osteoporotic fractures in rats by increasing ultimate load and stiffness. The goal of this study is to investigate the anti-osteoporosis effects of DRE in diabetic rats co-treated with CGF. Blood glucose levels and bone mineral density (BMD) were measured. According to the data, DRE produced a significant increase in bone amount. DRE may help prevent and cure diabetic osteoporosis by increasing bone mineral density, according to one study. Keywords: Rhizoma Drynariae Diabetic osteoporosis, Streptozotocin induced diabetes, Canagliflozin
{"title":"Rhizoma Drynariae protects against Canaglifloxacin induced bone loss","authors":"A. Alqahtani, Khalid A. Asseri, Y. Asiri, K. Venkatesan, N. Khan, S. S. Alavudeen, E. M. Pappiya, Premalatha Paulsamy, R. Natarajan, Kalpana Krishnaraju, K. Venkatesan, K. Chidambaram","doi":"10.22192/ijcrcps.2021.08.09.004","DOIUrl":"https://doi.org/10.22192/ijcrcps.2021.08.09.004","url":null,"abstract":"Osteoporosis is a condition marked by a loss of bone mass and degradation of the bone microstructure, both of which lead to increased fragility and consequent fragility fractures, particularly in the elderly. Rhizoma Drynariae (DRE) is one of the most often used herbal remedies for osteoporosis therapy. Transdermal drug administration is a well- established new method for drug delivery that offers numerous benefits over conventional routes. Wistar albino rats were split into five groups of six rats each: vehicle control, diabeticgroup, DRE group, Canagliflozin (CGF), and CGF + DRE group. Each medication was given by gastric gavage once a day for 35 days. The drug canagliflozin appears to raise the risk of fractur. When compared to the control group, DRE treatment increased bone strength at the femoral diaphysis in osteoporotic fractures in rats by increasing ultimate load and stiffness. The goal of this study is to investigate the anti-osteoporosis effects of DRE in diabetic rats co-treated with CGF. Blood glucose levels and bone mineral density (BMD) were measured. According to the data, DRE produced a significant increase in bone amount. DRE may help prevent and cure diabetic osteoporosis by increasing bone mineral density, according to one study. Keywords: Rhizoma Drynariae Diabetic osteoporosis, Streptozotocin induced diabetes, Canagliflozin","PeriodicalId":13826,"journal":{"name":"International Journal of Current Research in Chemistry and Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81683042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-03DOI: 10.22192/ijcrcps.2021.08.09.001
Absar Ahmed Qureshi, S. Alshahrani, Premalatha Paulsamy, K. Venkatesan, P. Sethuraj
A Quasi experimental design was adopted for this study to find out the effectiveness of quadriceps strengthening exercise program on pain and functional ability of women with knee osteoarthritis (OA). Fifty women with OA were selected in which first 25 women were enrolled in the control group and second 25 women were allotted in the exercise group. Assessments were performed at baseline and at 8 weeks. The functional ability was assessed using the Timed Up and Go (TUG) test and Numerical Rating Scale (NRS) was used to assess the pain level .For the exercise group, quadriceps strengthening exercises were taught and asked the patients to follow the exercise schedule for 8 weeks. The study results show that the pain and functional abilty scores were improved in the exercise group and the difference was statistically significant (p<0.001). The study concluded that a simple quadriceps strengthening exercise programme can significantly improve self reported knee pain and functional ability among women with Knee osteoarthritis. Keywords: Osteoarthritis, Pain, Functional Ability, Exercise, Quadriceps strengthening, Timed Up and Go (TUG) test, Numerical Rating Scale (NRS)
本研究采用准实验设计，探讨股四头肌强化训练方案对女性膝关节骨性关节炎(OA)患者疼痛和功能能力的影响。50名患有骨性关节炎的女性被选中，其中前25名女性被分配到对照组，后25名女性被分配到锻炼组。在基线和8周时进行评估。采用TUG (Timed Up and Go)测试和NRS (Numerical Rating Scale)评估疼痛程度。运动组进行股四头肌强化训练，并要求患者遵循8周的运动计划。研究结果显示，运动组疼痛和功能能力评分均有改善，差异有统计学意义(p<0.001)。该研究得出结论，一个简单的股四头肌强化锻炼计划可以显著改善患有膝骨关节炎的女性自我报告的膝关节疼痛和功能能力。关键词:骨关节炎，疼痛，功能能力，运动，股四头肌强化，Timed Up and Go (TUG)测试，数值评定量表(NRS)
{"title":"Effectiveness of the quadriceps strengthening exercise on pain and functional ability of the women with Osteoarthritis (OA)","authors":"Absar Ahmed Qureshi, S. Alshahrani, Premalatha Paulsamy, K. Venkatesan, P. Sethuraj","doi":"10.22192/ijcrcps.2021.08.09.001","DOIUrl":"https://doi.org/10.22192/ijcrcps.2021.08.09.001","url":null,"abstract":"A Quasi experimental design was adopted for this study to find out the effectiveness of quadriceps strengthening exercise program on pain and functional ability of women with knee osteoarthritis (OA). Fifty women with OA were selected in which first 25 women were enrolled in the control group and second 25 women were allotted in the exercise group. Assessments were performed at baseline and at 8 weeks. The functional ability was assessed using the Timed Up and Go (TUG) test and Numerical Rating Scale (NRS) was used to assess the pain level .For the exercise group, quadriceps strengthening exercises were taught and asked the patients to follow the exercise schedule for 8 weeks. The study results show that the pain and functional abilty scores were improved in the exercise group and the difference was statistically significant (p<0.001). The study concluded that a simple quadriceps strengthening exercise programme can significantly improve self reported knee pain and functional ability among women with Knee osteoarthritis. Keywords: Osteoarthritis, Pain, Functional Ability, Exercise, Quadriceps strengthening, Timed Up and Go (TUG) test, Numerical Rating Scale (NRS)","PeriodicalId":13826,"journal":{"name":"International Journal of Current Research in Chemistry and Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74980945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-03DOI: 10.22192/ijcrcps.2021.08.09.003
Khalid A. Asseri, Y. Asiri, A. Alqahtani, K. Venkatesan, N. Khan, V. Easwaran, E. M. Pappiya, Premalatha Paulsamy, R. Natarajan, Kalpana Krishnaraju, K. Venkatesan, K. Chidambaram
The dried root of Dipsacus asperoides is known as Radix Dipsaci extract(RDE). It's a kidney-toning herbal medication with a lengthy track record of safe usage in the treatment of bone fractures and joint disorders. The drug rosiglitazone (RSG) causes an imbalance in bone remodelling, which results in increased apoptotic death of osteogenic cells and decreased bone production. The goal of this study was to investigate the effects of RDE on RSGinduced bone loss in diabetic rats in a systematic way. Five groups of six Wistar albino rats were studied: control (vehicle therapy), Streptozotocin (diabetes) group, RDE group, Rosiglitazone, and Rosiglitazone +RDE group. Insulin, oxidative stress, and bone turnover markers in the blood were all detected using ELISA tests. When compared to diabetic control rats, RDE therapy significantly raised insulin and osteocalcin levels. RDE may be able to prevent diabetic osteoporosis by boosting osteogenesis and lowering oxidative stress in the bone.These findings support the use of RDE as a bone loss inhibiting in diabetics. Well-designed clinical trials are likely to yield further scientific evidence on its bone-protective effects and safety. Keywords: Radix Dipsaci, Diabetic osteoporosis, Rosiglitazone.
{"title":"Radix Dipsaci extract protects against Rosiglitazone induced bone loss","authors":"Khalid A. Asseri, Y. Asiri, A. Alqahtani, K. Venkatesan, N. Khan, V. Easwaran, E. M. Pappiya, Premalatha Paulsamy, R. Natarajan, Kalpana Krishnaraju, K. Venkatesan, K. Chidambaram","doi":"10.22192/ijcrcps.2021.08.09.003","DOIUrl":"https://doi.org/10.22192/ijcrcps.2021.08.09.003","url":null,"abstract":"The dried root of Dipsacus asperoides is known as Radix Dipsaci extract(RDE). It's a kidney-toning herbal medication with a lengthy track record of safe usage in the treatment of bone fractures and joint disorders. The drug rosiglitazone (RSG) causes an imbalance in bone remodelling, which results in increased apoptotic death of osteogenic cells and decreased bone production. The goal of this study was to investigate the effects of RDE on RSGinduced bone loss in diabetic rats in a systematic way. Five groups of six Wistar albino rats were studied: control (vehicle therapy), Streptozotocin (diabetes) group, RDE group, Rosiglitazone, and Rosiglitazone +RDE group. Insulin, oxidative stress, and bone turnover markers in the blood were all detected using ELISA tests. When compared to diabetic control rats, RDE therapy significantly raised insulin and osteocalcin levels. RDE may be able to prevent diabetic osteoporosis by boosting osteogenesis and lowering oxidative stress in the bone.These findings support the use of RDE as a bone loss inhibiting in diabetics. Well-designed clinical trials are likely to yield further scientific evidence on its bone-protective effects and safety. Keywords: Radix Dipsaci, Diabetic osteoporosis, Rosiglitazone.","PeriodicalId":13826,"journal":{"name":"International Journal of Current Research in Chemistry and Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87271262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-09-03DOI: 10.22192/ijcrcps.2021.08.09.005
Y. Asiri, A. Alqahtani, Khalid A. Asseri, K. Venkatesan, N. Khan, V. Easwaran, E. M. Pappiya, Premalatha Paulsamy, R. Natarajan, Kalpana Krishnaraj, K. Chidambaram, K. Venkatesan
The root of Pueraria labata, Puerariae radix(PR), a leguminous plant that grows wild, is one of the first and most significant basic herbs used in traditional medicine for a variety of therapeutic uses. PR is high in isoflavonoids including daidzein and genistein, which have been shown to protect against bone loss caused by oestrogen insufficiency. In an osteoporotic animal model, soybean isoflavones have been shown to reduce bone loss. CGF (canagliflozin) appears to raise the risk of fractur. In diabetic rats, the potential function of PR in reversing CGFinduced bone loss was investigated. A rat model was used to investigate the effects of Puerariae radix extract (PRE) on blood glucose, HBA1C levels, and bone mineral density. Control group (vehicle therapy), Diabetic group, `PRE group, Canagliflozin (CGF), and CGF +PRE group were all made up of six Wistar albino rats. Each medication was given by gastric gavage once a day for 35 days. PRE treatment increased bone mass substantially when compared to normal controls. This suggests that PRE might be developed as an alternative therapy for osteoporosis caused by anti-diabetic drugs. Keywords: Puerariae radix, Diabetic osteoporosis, streptozotocin, Canagliflozin.
{"title":"Adverse effect of Canaglifloxacin on bone is reversed by Puerariae radix in rat model of diabetics","authors":"Y. Asiri, A. Alqahtani, Khalid A. Asseri, K. Venkatesan, N. Khan, V. Easwaran, E. M. Pappiya, Premalatha Paulsamy, R. Natarajan, Kalpana Krishnaraj, K. Chidambaram, K. Venkatesan","doi":"10.22192/ijcrcps.2021.08.09.005","DOIUrl":"https://doi.org/10.22192/ijcrcps.2021.08.09.005","url":null,"abstract":"The root of Pueraria labata, Puerariae radix(PR), a leguminous plant that grows wild, is one of the first and most significant basic herbs used in traditional medicine for a variety of therapeutic uses. PR is high in isoflavonoids including daidzein and genistein, which have been shown to protect against bone loss caused by oestrogen insufficiency. In an osteoporotic animal model, soybean isoflavones have been shown to reduce bone loss. CGF (canagliflozin) appears to raise the risk of fractur. In diabetic rats, the potential function of PR in reversing CGFinduced bone loss was investigated. A rat model was used to investigate the effects of Puerariae radix extract (PRE) on blood glucose, HBA1C levels, and bone mineral density. Control group (vehicle therapy), Diabetic group, `PRE group, Canagliflozin (CGF), and CGF +PRE group were all made up of six Wistar albino rats. Each medication was given by gastric gavage once a day for 35 days. PRE treatment increased bone mass substantially when compared to normal controls. This suggests that PRE might be developed as an alternative therapy for osteoporosis caused by anti-diabetic drugs. Keywords: Puerariae radix, Diabetic osteoporosis, streptozotocin, Canagliflozin.","PeriodicalId":13826,"journal":{"name":"International Journal of Current Research in Chemistry and Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89715607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-28DOI: 10.22192/ijcrcps.2021.08.08.004
J. Eswari, Premalatha Paulsamy, A. A. Qureshi, K. Venkatesan, P. Sethuraj
Effective contraception plays a vital role in the economic advancement and reproductive health of women. This study aimed to assess the knowledge and attitude regarding contraception of female college students of a university. A descriptive study design was used with 100 female students of different departments including Arts and Science, engineering, nursing etc, who were selected by convenient sampling technique. A self reported tool was used with 3 sections including demographic data, knowledge questionnaire and a 3 point Likert scale to assess the attitude. The overall level of knowledge (8.86 ±3.56) shows that there was inadequate knowledge among the female college students on contraception. The overall percentage of female college students with a positive attitude was only 28.66%. There was no correlation between participants' knowledge of contraception and their attitudes about it. (x2 = 1.17, df = 1, p = 0.28). The study concludes that there is an urgent need to improve the knowledge of the female college students on contraception to prevent unwanted pregnancies as well as maternal and neonatal mortality and morbidity. Keywords: Knowledge, Attitude, Female College Students, Contraception, Family Planning
有效避孕对妇女的经济发展和生殖健康起着至关重要的作用。本研究旨在了解某高校女大学生的避孕知识与态度。采用描述性研究设计，选取文理、工科、护理等不同院系的100名女大学生，采用方便抽样法。采用自我报告工具，包括人口统计资料、知识问卷和李克特量表3个部分来评估态度。总体知识水平(8.86±3.56)表明女大学生对避孕知识的了解不足。持积极态度的女大学生总体比例仅为28.66%。参与者的避孕知识和他们对避孕的态度之间没有相关性。(x2 = 1.17, df = 1, p = 0.28)。研究认为，提高女大学生的避孕知识，预防意外怀孕，降低孕产妇和新生儿的死亡率和发病率是当务之急。关键词:知识，态度，女大学生，避孕，计划生育
{"title":"A Descriptive Study on the Knowledge and Attitude of Female College Students towards Contraception","authors":"J. Eswari, Premalatha Paulsamy, A. A. Qureshi, K. Venkatesan, P. Sethuraj","doi":"10.22192/ijcrcps.2021.08.08.004","DOIUrl":"https://doi.org/10.22192/ijcrcps.2021.08.08.004","url":null,"abstract":"Effective contraception plays a vital role in the economic advancement and reproductive health of women. This study aimed to assess the knowledge and attitude regarding contraception of female college students of a university. A descriptive study design was used with 100 female students of different departments including Arts and Science, engineering, nursing etc, who were selected by convenient sampling technique. A self reported tool was used with 3 sections including demographic data, knowledge questionnaire and a 3 point Likert scale to assess the attitude. The overall level of knowledge (8.86 ±3.56) shows that there was inadequate knowledge among the female college students on contraception. The overall percentage of female college students with a positive attitude was only 28.66%. There was no correlation between participants' knowledge of contraception and their attitudes about it. (x2 = 1.17, df = 1, p = 0.28). The study concludes that there is an urgent need to improve the knowledge of the female college students on contraception to prevent unwanted pregnancies as well as maternal and neonatal mortality and morbidity. Keywords: Knowledge, Attitude, Female College Students, Contraception, Family Planning","PeriodicalId":13826,"journal":{"name":"International Journal of Current Research in Chemistry and Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81258573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-28DOI: 10.22192/ijcrcps.2021.08.08.003
S. Alshahrani, A. A. Qureshi, Premalatha Paulsamy, K. Venkatesan, P. Sethuraj
Pressure ulcers (PU) are still a serious complication of immobility and a source of frustration for healthcare providers. Until now, the rate of occurrence and prevalence are alarmingly high. Nurses' knowledge and attitudes play a critical role in prevention of PU. The purpose of this study was to find out the level of knowledge and attitudes of final-year nursing students towards prevention of PU. A quantitative, exploratory cross-sectional design was used with fifty final-year students being recruited at random using a simple random sample technique. The tool had three sections: socio-demographic data of nursing students, PUKAT (Pressure Ulcer Knowledge Assessment Tool), and APuP (Attitudes towards Pressure Ulcers Prevention tool). According to the findings of this study, the average knowledge score of final year nursing students was 48.7% (Mean = 14.85; SD=6.01). Only 18 (36%) nurses got a score of 60% or above on the PUKAT assessment instrument, which is regarded as satisfactory. Though there was a positive attitude prevailed among final year nursing students on prevention of PU, only 44 % of responders (n = 22) attained the satisfactory score. Also, there was a moderate correlation between knowledge and attitude of the nursing students on prevention of PU. Keywords: Knowledge, Attitude, Nursing Students, Prevention, Pressure Ulcers
{"title":"Knowledge and Attitude of Nursing Students on the Prevention of Pressure Ulcers","authors":"S. Alshahrani, A. A. Qureshi, Premalatha Paulsamy, K. Venkatesan, P. Sethuraj","doi":"10.22192/ijcrcps.2021.08.08.003","DOIUrl":"https://doi.org/10.22192/ijcrcps.2021.08.08.003","url":null,"abstract":"Pressure ulcers (PU) are still a serious complication of immobility and a source of frustration for healthcare providers. Until now, the rate of occurrence and prevalence are alarmingly high. Nurses' knowledge and attitudes play a critical role in prevention of PU. The purpose of this study was to find out the level of knowledge and attitudes of final-year nursing students towards prevention of PU. A quantitative, exploratory cross-sectional design was used with fifty final-year students being recruited at random using a simple random sample technique. The tool had three sections: socio-demographic data of nursing students, PUKAT (Pressure Ulcer Knowledge Assessment Tool), and APuP (Attitudes towards Pressure Ulcers Prevention tool). According to the findings of this study, the average knowledge score of final year nursing students was 48.7% (Mean = 14.85; SD=6.01). Only 18 (36%) nurses got a score of 60% or above on the PUKAT assessment instrument, which is regarded as satisfactory. Though there was a positive attitude prevailed among final year nursing students on prevention of PU, only 44 % of responders (n = 22) attained the satisfactory score. Also, there was a moderate correlation between knowledge and attitude of the nursing students on prevention of PU. Keywords: Knowledge, Attitude, Nursing Students, Prevention, Pressure Ulcers","PeriodicalId":13826,"journal":{"name":"International Journal of Current Research in Chemistry and Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91549572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-28DOI: 10.22192/ijcrcps.2021.08.08.002
A. A. Qureshi, S. Alshahrani, Premalatha Paulsamy, Ghadha Mohammed Ali Al –Asbi, K. Venkatesan, P. Sethuraj
Stroke is the largest cause of death worldwide and the primary cause of disability. As a result, it was required to investigate the level of hypertension patients' knowledge of risk factors and warning symptoms. A descriptive cross- sectional study carried out among 200 hypertensive patients who were selected using purposive sampling technique. The tool was constructed with three sections: demographic data, risk factor awareness, and stroke signs and symptoms. The study results show that he total mean of knowledge on risk factors of stroke was 11.73 with the SD of 2.17 and warning signs was 9.61 with the SD of 1.99. The gender, age and level of education had significant relationship with knowledge of the hypertensive patients on risk factors of stroke at p=0.05 level. The study concludes that the majority of hypertension patients had insufficient understanding of stroke risk factors and warning symptoms. Hence, the first priority should be to raise public knowledge of hypertension and support primary prevention in order to reduce the morbidity and mortality related to stroke. Keywords: Knowledge, Hypertensive Patients, Risk Factors, Warning Signs, Stroke
{"title":"Knowledge of hypertensive patients on risk factors and warning signs of stroke","authors":"A. A. Qureshi, S. Alshahrani, Premalatha Paulsamy, Ghadha Mohammed Ali Al –Asbi, K. Venkatesan, P. Sethuraj","doi":"10.22192/ijcrcps.2021.08.08.002","DOIUrl":"https://doi.org/10.22192/ijcrcps.2021.08.08.002","url":null,"abstract":"Stroke is the largest cause of death worldwide and the primary cause of disability. As a result, it was required to investigate the level of hypertension patients' knowledge of risk factors and warning symptoms. A descriptive cross- sectional study carried out among 200 hypertensive patients who were selected using purposive sampling technique. The tool was constructed with three sections: demographic data, risk factor awareness, and stroke signs and symptoms. The study results show that he total mean of knowledge on risk factors of stroke was 11.73 with the SD of 2.17 and warning signs was 9.61 with the SD of 1.99. The gender, age and level of education had significant relationship with knowledge of the hypertensive patients on risk factors of stroke at p=0.05 level. The study concludes that the majority of hypertension patients had insufficient understanding of stroke risk factors and warning symptoms. Hence, the first priority should be to raise public knowledge of hypertension and support primary prevention in order to reduce the morbidity and mortality related to stroke. Keywords: Knowledge, Hypertensive Patients, Risk Factors, Warning Signs, Stroke","PeriodicalId":13826,"journal":{"name":"International Journal of Current Research in Chemistry and Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85125008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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