Pub Date : 2018-10-16DOI: 10.38111/ijapb.20180404002
M. Manoj Kumar, B. Renuka Swathi, G. Padma Sree
{"title":"ADMET PREDICTORS ARE THE TOOLS FOR THE ENHANCEMENT OF DRUG DESIGN AND DEVELOPMENT: A SYSTEMATIC REVIEW","authors":"M. Manoj Kumar, B. Renuka Swathi, G. Padma Sree","doi":"10.38111/ijapb.20180404002","DOIUrl":"https://doi.org/10.38111/ijapb.20180404002","url":null,"abstract":"","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90440855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-10-16DOI: 10.38111/ijapb.20180404001
Yaswanth Kumar K, M. K, V. Eggadi, Sharavanabhava B.S
Toxic Epidermal Necrolysis (TEN) is a rare but severe life-threatening skin disorder characterized by fever, headache and mucocutaneous lesion leading to necrolysis and detachment of full thickness of epidermis with sloughing, generally precipitated by drugs. A 68 years old male patient was admitted to hospital with a history of high-grade fever, headache and blurred vision. For his present illness he used Phenytoin. He was apparently asymptomatic for 5 days then patient presented with brownish-black discoloration of skin and rash all over the body. Nikolsky’s sign was positive. Referral from a dermatologist confirmed the diagnosis of Toxic Epidermal Necrolysis. Before starting treatment with anticonvulsants and other drugs that cause adverse reactions, patients are to be screened so that further complications and mortality can be reduced.
{"title":"PHENYTOIN INDUCED TOXIC EPIDERMAL NECROLYSIS - A CASE REPORT","authors":"Yaswanth Kumar K, M. K, V. Eggadi, Sharavanabhava B.S","doi":"10.38111/ijapb.20180404001","DOIUrl":"https://doi.org/10.38111/ijapb.20180404001","url":null,"abstract":"Toxic Epidermal Necrolysis (TEN) is a rare but severe life-threatening skin disorder characterized by fever, headache and mucocutaneous lesion leading to necrolysis and detachment of full thickness of epidermis with sloughing, generally precipitated by drugs. A 68 years old male patient was admitted to hospital with a history of high-grade fever, headache and blurred vision. For his present illness he used Phenytoin. He was apparently asymptomatic for 5 days then patient presented with brownish-black discoloration of skin and rash all over the body. Nikolsky’s sign was positive. Referral from a dermatologist confirmed the diagnosis of Toxic Epidermal Necrolysis. Before starting treatment with anticonvulsants and other drugs that cause adverse reactions, patients are to be screened so that further complications and mortality can be reduced.","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81805991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-25DOI: 10.38111/ijapb.20180403001
Yaswanth Kumar K, A. G., M. K, V. Eggadi, Sharavanabhava B.S
Leprosy has prominent effect on hands and feet. Bone deformities are the most occurred complication in leprosy and can result to deformity and disability. Bone resorption leads to the increased levels of ALP, U. CA/CR level ratio. Decreased hemoglobin level is most observed in these patients. The leprosy patients were compared with healthy. U. CA/CR levels is used for studying bone resorption which may be associated with new bone formation it can be evaluated by estimating ALP levels. Blood changes is also studied by estimating Haemoglobin in Hansen’s patients. The mean value U.CA/CR ratio, ALP is also increased in cases when compared to controls which indicate bone resorption coupled with compensatory new bone formation. The Hb% was also decreased in leprosy patients. The present study suggests an increased bone resorption in leprosy patients and is attributed to compensatory new bone formation coupled with bone resorption. In conclusion our data suggests that therapy aimed at reducing bone loss may benefit these patients with high bone turnover and decrease the deformities and disease burden due to leprosy.
{"title":"EVALUATION OF BIOCHEMICAL MARKERS FOR BONE CHANGES IN LEPROSY PATIENTS","authors":"Yaswanth Kumar K, A. G., M. K, V. Eggadi, Sharavanabhava B.S","doi":"10.38111/ijapb.20180403001","DOIUrl":"https://doi.org/10.38111/ijapb.20180403001","url":null,"abstract":"Leprosy has prominent effect on hands and feet. Bone deformities are the most occurred complication in leprosy and can result to deformity and disability. Bone resorption leads to the increased levels of ALP, U. CA/CR level ratio. Decreased hemoglobin level is most observed in these patients. The leprosy patients were compared with healthy. U. CA/CR levels is used for studying bone resorption which may be associated with new bone formation it can be evaluated by estimating ALP levels. Blood changes is also studied by estimating Haemoglobin in Hansen’s patients. The mean value U.CA/CR ratio, ALP is also increased in cases when compared to controls which indicate bone resorption coupled with compensatory new bone formation. The Hb% was also decreased in leprosy patients. The present study suggests an increased bone resorption in leprosy patients and is attributed to compensatory new bone formation coupled with bone resorption. In conclusion our data suggests that therapy aimed at reducing bone loss may benefit these patients with high bone turnover and decrease the deformities and disease burden due to leprosy.","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85606748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.38111/ijapb.20210701006
R. T, P. S., D. A, Shravan Kumar Y
{"title":"Formulation and Evaluation of Valacyclovir Hydrochloride Effervescent Floating Tablets","authors":"R. T, P. S., D. A, Shravan Kumar Y","doi":"10.38111/ijapb.20210701006","DOIUrl":"https://doi.org/10.38111/ijapb.20210701006","url":null,"abstract":"","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83386560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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