International Journal of Dermatology最新文献

Background: Vitiligo can cause substantial psychosocial distress, including stigma, depression, and social exclusion. Cultural factors shape disease perception and information needs. Online search queries provide real-time indicators of unmet public interests. We investigated language- and culture-associated differences in vitiligo-related online information seeking in Germany to inform culturally competent dermatologic care.

Methods: We conducted a retrospective observational study using anonymized data from the Google Ads Keyword Planner (October 2019-May 2023). Search terms related to vitiligo were analyzed in six languages (German, Turkish, Arabic, English, Russian, Polish), representing the most commonly spoken languages in Germany. Keywords were thematically categorized and comparatively analyzed across languages.

Results: A total of 7.8 million vitiligo-related search queries were identified, with the majority in German. "General information" was the most frequently searched category, except in Arabic, where "treatment options" ranked highest. Treatment queries in Turkish and Arabic more frequently mentioned alternative therapies and home remedies than specific evidence-based treatments. Notable cross-language differences emerged in searches for camouflage, depigmentation, faith-related coping, and psychosocial burden.

Conclusions: Online search behavior reveals both shared and language-specific interests about vitiligo. Observed language patterns are hypothesis-generating and may reflect differences in information access, healthcare navigation, and language barriers rather than inherent cultural preferences. Language-specific patterns highlight the need for culturally sensitive communication, multilingual patient education, and inclusive care models in dermatology to promote health equity.

An elderly woman presented with a chronic, infiltrative plaque on the nasal dorsum and malar region, persisting for decades. Histopathology revealed a granulomatous process, but the etiology remained uncertain despite extensive investigation. This case illustrates the diagnostic challenge of a slowly progressive facial plaque with tuberculoid granulomas and negative microbiological special stains, highlighting the importance of clinicopathological correlation and follow-up in endemic areas for chronic granulomatous dermatoses.

Background: Autoimmune bullous diseases (AIBDs) constitute a rare yet potentially life-threatening subset of immune-related adverse events induced by immune checkpoint inhibitors (ICIs). However, the characteristics of ICI-induced AIBDs (ICI-AIBDs) and the factors influencing patient survival remain incompletely characterized. Therefore, we aimed to synthesize the available information on ICI-AIBD patients and sought to explore factors potentially influencing the survival outcome of this population.

Methods: A systematic search of 5 databases was conducted. Cox regression analysis was used to identify potential factors affecting patient survival outcomes.

Results: Finally, a total of 188 studies with 319 participants were analyzed. The spectrum of AIBDs comprised bullous pemphigoid (n = 254, 79.6%), lichen planus pemphigoides (n = 34, 10.7%), mucous membrane pemphigoid (n = 11, 3.4%), pemphigus group (n = 7, 2.2%), linear IgA bullous dermatosis (n = 5, 1.6%), primarily induced by programmed cell death protein 1 inhibitors. In the exploratory analysis, female (hazard ratio [HR], 2.35; 95% confidence interval [CI], 1.10-5.02; p = 0.020) and pemphigus group (HR, 7.09; 95% CI, 1.87-26.96; p = 0.003) were potentially associated with higher mortality, whereas topical glucocorticoid therapy was potentially protective (HR, 0.44; 95% CI, 0.21-0.93; p = 0.025).

Conclusions: In conclusion, we delineate the full clinical spectrum of ICI-AIBDs, tentatively exploring factors potentially affecting patients' survival, which provides insights for individualized therapy and may inform future clinical practice.