Pub Date : 2024-01-15DOI: 10.1097/ipc.0000000000001334
Melania Iñigo, Daniela Svedin, Alex Vacaroaia, Alejandra Pérez-García, Cristina Lillo, Felipe Garrido
During the COVID-19 pandemic, return of children and adolescents to schools and colleges, with infections preventive restrictions, occurred in September 2020. In spring 2021, these restrictions were lifted. In this context, health systems noticed an apparent change in the seasonality and epidemiology of common viral infections in both adult and pediatric populations. We retrospectively analyzed the results of respiratory virus polymerase chain reaction (PCR) carried out on pediatric nasopharynx samples, tested with multiplex PCR assay to detect the presence of common respiratory viruses. We reviewed a total of 1338 PCR samples from our microbiology laboratory. After the return to school, the most frequently identified virus was rhinovirus-enterovirus (27.8%), followed by respiratory syncytial virus (21%). An increase of positive respiratory syncytial virus PCRs was detected out of its common epidemic period from spring to summer of 2021. A peak in influenza virus infections was observed between March and May 2022. The lifting of restrictions due to COVID-19 had a significant impact on the type of virus detected. We conclude that with the end of the COVID-19 pandemic, the return to school of children and adolescents, and lifting of preventative restrictions, the circulation of common viruses within this age group increased gradually, showing an unusual delay and peaks outside its epidemic periods.
{"title":"Seasonal Changes of Common Viral Infections in Children After Their Return to School During COVID-19 Pandemic","authors":"Melania Iñigo, Daniela Svedin, Alex Vacaroaia, Alejandra Pérez-García, Cristina Lillo, Felipe Garrido","doi":"10.1097/ipc.0000000000001334","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001334","url":null,"abstract":"\u0000 \u0000 \u0000 During the COVID-19 pandemic, return of children and adolescents to schools and colleges, with infections preventive restrictions, occurred in September 2020. In spring 2021, these restrictions were lifted. In this context, health systems noticed an apparent change in the seasonality and epidemiology of common viral infections in both adult and pediatric populations.\u0000 \u0000 \u0000 \u0000 We retrospectively analyzed the results of respiratory virus polymerase chain reaction (PCR) carried out on pediatric nasopharynx samples, tested with multiplex PCR assay to detect the presence of common respiratory viruses.\u0000 \u0000 \u0000 \u0000 We reviewed a total of 1338 PCR samples from our microbiology laboratory. After the return to school, the most frequently identified virus was rhinovirus-enterovirus (27.8%), followed by respiratory syncytial virus (21%). An increase of positive respiratory syncytial virus PCRs was detected out of its common epidemic period from spring to summer of 2021. A peak in influenza virus infections was observed between March and May 2022. The lifting of restrictions due to COVID-19 had a significant impact on the type of virus detected.\u0000 \u0000 \u0000 \u0000 We conclude that with the end of the COVID-19 pandemic, the return to school of children and adolescents, and lifting of preventative restrictions, the circulation of common viruses within this age group increased gradually, showing an unusual delay and peaks outside its epidemic periods.\u0000","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139529219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.1097/ipc.0000000000001343
Y. Nadir, P. Kiran, Damla Erturk, Uğur Uzun, T. Yavuz, G. Ersan, Hale Turan Ozden, S. S. Senger
Secondary bacterial infections can worsen the prognosis for COVID-19, especially in patients with severe infections. Thus, we aim to investigate the effect of secondary catheter-related bloodstream infections on the course of COVID-19 infection. This is a retrospective, nested case-control study and included 236 confirmed COVID-19 infection hospitalized patients, divided into 2 groups (COVID-19, n = 64; non–COVID-19, n = 172) according to SARS-CoV-2 RT-PCR results. The age, sex, and prevalence of chronic diseases were similar in both groups. Klebsiella pneumoniae (31.2%) and Acinetobacter baumannii (21.9%) were the predominant microorganisms in the COVID-19 group. Only A. baumannii was statistically higher in the COVID-19 group (P = 0.046). There were no significant differences in terms of resistance profiles. The 30-day mortality was significantly higher in the COVID-19 group (56.3%) than in the non–COVID-19 group (38.4%) (P = 0.014). There was no significant difference in the length of stay between the 2 groups. The multiple logistic regression analysis of risk factors for 30-day mortality revealed that COVID-19 positivity (odds ratio [OR], 2.167; 95% confidence interval [CI], 1.056–4.446; P = 0.035), infection with extensively drug-resistant bacteria (OR, 2.949; 95% CI, 1.311–6.636; P = 0.009), and infection with pandrug-resistant bacteria (OR, 3.601; 95% CI, 1.213–10.689; P = 0.021) were independent risk factors for 30-day mortality. As a conclusion, this study demonstrated that COVID-19 positivity is an independent risk factor for 30-day mortality of secondary catheter-related bloodstream infections. Gram-negative bacteria were the predominant microorganisms, with A. baumannii being statistically higher in the COVID-19 group compared with the non–COVID-19 group. However, there were no statistically significant differences in terms of the resistance profile of microorganisms.
{"title":"The Impact of Secondary Catheter-Related Bloodstream Infection on the Course of COVID-19 Infection","authors":"Y. Nadir, P. Kiran, Damla Erturk, Uğur Uzun, T. Yavuz, G. Ersan, Hale Turan Ozden, S. S. Senger","doi":"10.1097/ipc.0000000000001343","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001343","url":null,"abstract":"\u0000 \u0000 \u0000 Secondary bacterial infections can worsen the prognosis for COVID-19, especially in patients with severe infections. Thus, we aim to investigate the effect of secondary catheter-related bloodstream infections on the course of COVID-19 infection.\u0000 \u0000 \u0000 \u0000 This is a retrospective, nested case-control study and included 236 confirmed COVID-19 infection hospitalized patients, divided into 2 groups (COVID-19, n = 64; non–COVID-19, n = 172) according to SARS-CoV-2 RT-PCR results.\u0000 \u0000 \u0000 \u0000 The age, sex, and prevalence of chronic diseases were similar in both groups. Klebsiella pneumoniae (31.2%) and Acinetobacter baumannii (21.9%) were the predominant microorganisms in the COVID-19 group. Only A. baumannii was statistically higher in the COVID-19 group (P = 0.046). There were no significant differences in terms of resistance profiles. The 30-day mortality was significantly higher in the COVID-19 group (56.3%) than in the non–COVID-19 group (38.4%) (P = 0.014). There was no significant difference in the length of stay between the 2 groups. The multiple logistic regression analysis of risk factors for 30-day mortality revealed that COVID-19 positivity (odds ratio [OR], 2.167; 95% confidence interval [CI], 1.056–4.446; P = 0.035), infection with extensively drug-resistant bacteria (OR, 2.949; 95% CI, 1.311–6.636; P = 0.009), and infection with pandrug-resistant bacteria (OR, 3.601; 95% CI, 1.213–10.689; P = 0.021) were independent risk factors for 30-day mortality.\u0000 \u0000 \u0000 \u0000 As a conclusion, this study demonstrated that COVID-19 positivity is an independent risk factor for 30-day mortality of secondary catheter-related bloodstream infections. Gram-negative bacteria were the predominant microorganisms, with A. baumannii being statistically higher in the COVID-19 group compared with the non–COVID-19 group. However, there were no statistically significant differences in terms of the resistance profile of microorganisms.\u0000","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139529742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.1097/ipc.0000000000001336
Marwa N. Alsaraj, M. Qazzaz, M. Abed, F. Alassaf, M. Alfahad, Mahmood H. M. Jasim
Favipiravir and remdesivir have recently received more clinical interest for the management of COVID-19. The study aimed to explore the effectiveness of favipiravir or remdesivir on the clinical outcome of SARS-CoV-2 patients in comparison with standard care. All patients were given standard care before being randomized into the following 3 groups: standard care group (standard care only), remdesivir group (remdesivir and standard care), and favipiravir group (group 3, favipiravir and standard care). The primary endpoint of the study was time to recovery or the clinical condition of patients on day 14. A total of 156 patients underwent randomization (53 assigned to standard care group, 51 to favipiravir group, and 52 to remdesivir group). The percentage of death in favipiravir and remdesivir groups was higher than those in the standard care group and likewise the liver enzymes. Studying the time to starting therapy showed that early administration of antivirals resulted in lower percentage of mortality. The ratio of hazard for early favipiravir and remdesivir was lower in comparison with those treated with late administration of the same drugs (hazard ratio, 0.62; 95% confidence interval [CI], 0.62–0.73 vs 3.22; 95% CI, 3.21–3.44, respectively, for favipiravir and 0.11; 95% CI, 0.10–0.12 vs 3.44; 95% CI, 3.43–3.55, respectively, for remdesivir). For favipiravir or remdesivir to have more beneficial effects than standard care alone for SARS-CoV-2 patients, they need to be started as early as possible. However, regular monitoring of liver function is required.
{"title":"Consequence of Antivirals Versus Standard Care on Clinical Situation in Patients With COVID-19","authors":"Marwa N. Alsaraj, M. Qazzaz, M. Abed, F. Alassaf, M. Alfahad, Mahmood H. M. Jasim","doi":"10.1097/ipc.0000000000001336","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001336","url":null,"abstract":"\u0000 Favipiravir and remdesivir have recently received more clinical interest for the management of COVID-19. The study aimed to explore the effectiveness of favipiravir or remdesivir on the clinical outcome of SARS-CoV-2 patients in comparison with standard care. All patients were given standard care before being randomized into the following 3 groups: standard care group (standard care only), remdesivir group (remdesivir and standard care), and favipiravir group (group 3, favipiravir and standard care). The primary endpoint of the study was time to recovery or the clinical condition of patients on day 14. A total of 156 patients underwent randomization (53 assigned to standard care group, 51 to favipiravir group, and 52 to remdesivir group). The percentage of death in favipiravir and remdesivir groups was higher than those in the standard care group and likewise the liver enzymes. Studying the time to starting therapy showed that early administration of antivirals resulted in lower percentage of mortality. The ratio of hazard for early favipiravir and remdesivir was lower in comparison with those treated with late administration of the same drugs (hazard ratio, 0.62; 95% confidence interval [CI], 0.62–0.73 vs 3.22; 95% CI, 3.21–3.44, respectively, for favipiravir and 0.11; 95% CI, 0.10–0.12 vs 3.44; 95% CI, 3.43–3.55, respectively, for remdesivir). For favipiravir or remdesivir to have more beneficial effects than standard care alone for SARS-CoV-2 patients, they need to be started as early as possible. However, regular monitoring of liver function is required.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139447804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.1097/ipc.0000000000001337
V. Lobo Antuña, M. Lobo Antuña, Alejandro Fernández Soro, Benjamín Climent
Slamming is a widespread sexual practice that has been occurring in our society for more than a decade now. It has emerged as a public health issue because it associates many harm and risks, mainly derived from unsafe sexual practice and intravenous drug abuse. In the recent years, an additional concern has emerged regarding the rising occurrence of multidrug-resistant bacteria within the community, particularly strains of methicillin-resistant Staphylococcus aureus (S. aureus). In this report, we present the case of a human immunodeficiency virus patient addicted to parenteral-synthetic-cathinone use in the context of slamming, which developed necrotizing fasciitis by this resistant strain. As prevention measures, assuming the inevitability of slamming practices, harm reduction programs have been developed. Implemented for years, they aim to reduce the risks of addictive behaviors. This clinical case raises the question of whether methicillin-resistant S. aureus carrier screening and consequent decolonization among people who inject drugs, and more specifically among those engaged in slamming, should be included in the daily practice as another tool of these harm reduction programs.
{"title":"Screening and Decolonization Programs for Staphylococcus aureus Carriers in the Slamming-Practice Community: A New Strategy for Harm Reduction?","authors":"V. Lobo Antuña, M. Lobo Antuña, Alejandro Fernández Soro, Benjamín Climent","doi":"10.1097/ipc.0000000000001337","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001337","url":null,"abstract":"\u0000 Slamming is a widespread sexual practice that has been occurring in our society for more than a decade now. It has emerged as a public health issue because it associates many harm and risks, mainly derived from unsafe sexual practice and intravenous drug abuse. In the recent years, an additional concern has emerged regarding the rising occurrence of multidrug-resistant bacteria within the community, particularly strains of methicillin-resistant Staphylococcus aureus (S. aureus). In this report, we present the case of a human immunodeficiency virus patient addicted to parenteral-synthetic-cathinone use in the context of slamming, which developed necrotizing fasciitis by this resistant strain. As prevention measures, assuming the inevitability of slamming practices, harm reduction programs have been developed. Implemented for years, they aim to reduce the risks of addictive behaviors. This clinical case raises the question of whether methicillin-resistant S. aureus carrier screening and consequent decolonization among people who inject drugs, and more specifically among those engaged in slamming, should be included in the daily practice as another tool of these harm reduction programs.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139446324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-08DOI: 10.1097/ipc.0000000000001338
Lana Abusalem, A. M. Roy, Shagufta Siddiqui, Anissa Hodges, Priyenka Thapa, Ryan Dare
Schistosomiasis is a neglected tropical disease that remains a major threat to global health. Schistosoma is known to cause chronic urogenital infections with an increased risk of bladder carcinomas. We present a case of chronic latent Schistosoma haematobium infection in a US veteran identified several years after his active military duty in Iraq and Kuwait. This case highlights the need for proactive screening of returning veterans from endemic areas. It also leads us to wonder how many infected veterans remain undiagnosed, and how many of those who develop urothelial carcinomas had prior exposure to schistosomiasis during their service.
{"title":"A Tale of Mummified Eggs in Urine of a US Veteran","authors":"Lana Abusalem, A. M. Roy, Shagufta Siddiqui, Anissa Hodges, Priyenka Thapa, Ryan Dare","doi":"10.1097/ipc.0000000000001338","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001338","url":null,"abstract":"\u0000 Schistosomiasis is a neglected tropical disease that remains a major threat to global health. Schistosoma is known to cause chronic urogenital infections with an increased risk of bladder carcinomas. We present a case of chronic latent Schistosoma haematobium infection in a US veteran identified several years after his active military duty in Iraq and Kuwait. This case highlights the need for proactive screening of returning veterans from endemic areas. It also leads us to wonder how many infected veterans remain undiagnosed, and how many of those who develop urothelial carcinomas had prior exposure to schistosomiasis during their service.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139447246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-14DOI: 10.1097/ipc.0000000000001352
David J. Cennimo
{"title":"Lessons From the Mpox Education and Vaccination Campaign","authors":"David J. Cennimo","doi":"10.1097/ipc.0000000000001352","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001352","url":null,"abstract":"","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138973145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-14DOI: 10.1097/ipc.0000000000001303
Casey N. Pinto, Kathryn A. Risher, William Calo, Jennifer Kraschnewski, Emily S Heilbrunn, Catharine I. Paules
Little has been reported about mpox knowledge and vaccine willingness. We sought to collect timely data on mpox knowledge, perceived risk, and vaccine willingness among a representative sample of Pennsylvania adults. A cross-sectional web-based survey was conducted in September 2022. Four survey items were included to assess the population's knowledge and risk awareness surrounding the current mpox outbreak, and vaccine willingness if at risk for mpox. Data analyses included descriptive statistics and logistic regressions. Among 1039 survey respondents, few reported “no knowledge of mpox symptoms” (14.2%) or transmission modalities (12.5%). Those who perceived themselves at moderate/high risk were more likely to report knowing mpox symptoms (adjusted odds ratio [aOR] = 2.12) vs no risk. Men who have sex with men were more likely to know that mpox can mimic a sexually transmitted infection (aOR = 3.125), less likely to report not knowing any modes of transmission (aOR = 0.17), and more willing to be vaccinated (aOR = 4.35) than women who have sex with men. Self-perceived mpox risk was associated with willingness to get vaccinated (aOR low risk vs no risk = 3.45 [2.42–4.92], aOR moderate/high risk vs no risk = 9.93 [5.81–16.99]). Knowledge of mpox symptoms and transmission is strong in Pennsylvania, specifically among high-risk groups, but lacks a nuanced understanding specific to the current outbreak. Willingness to receive an mpox vaccine is highest in men who have sex with men and those that perceive themselves to be at highest risk. These findings highlight the need for more education on symptoms of the current outbreak and research on impact of the education on vaccine hesitancy.
{"title":"Mpox Knowledge and Vaccine Willingness Among a Representative Analysis of Adults in Pennsylvania","authors":"Casey N. Pinto, Kathryn A. Risher, William Calo, Jennifer Kraschnewski, Emily S Heilbrunn, Catharine I. Paules","doi":"10.1097/ipc.0000000000001303","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001303","url":null,"abstract":"\u0000 \u0000 Little has been reported about mpox knowledge and vaccine willingness. We sought to collect timely data on mpox knowledge, perceived risk, and vaccine willingness among a representative sample of Pennsylvania adults.\u0000 \u0000 \u0000 \u0000 A cross-sectional web-based survey was conducted in September 2022. Four survey items were included to assess the population's knowledge and risk awareness surrounding the current mpox outbreak, and vaccine willingness if at risk for mpox. Data analyses included descriptive statistics and logistic regressions.\u0000 \u0000 \u0000 \u0000 Among 1039 survey respondents, few reported “no knowledge of mpox symptoms” (14.2%) or transmission modalities (12.5%). Those who perceived themselves at moderate/high risk were more likely to report knowing mpox symptoms (adjusted odds ratio [aOR] = 2.12) vs no risk. Men who have sex with men were more likely to know that mpox can mimic a sexually transmitted infection (aOR = 3.125), less likely to report not knowing any modes of transmission (aOR = 0.17), and more willing to be vaccinated (aOR = 4.35) than women who have sex with men. Self-perceived mpox risk was associated with willingness to get vaccinated (aOR low risk vs no risk = 3.45 [2.42–4.92], aOR moderate/high risk vs no risk = 9.93 [5.81–16.99]).\u0000 \u0000 \u0000 \u0000 Knowledge of mpox symptoms and transmission is strong in Pennsylvania, specifically among high-risk groups, but lacks a nuanced understanding specific to the current outbreak. Willingness to receive an mpox vaccine is highest in men who have sex with men and those that perceive themselves to be at highest risk. These findings highlight the need for more education on symptoms of the current outbreak and research on impact of the education on vaccine hesitancy.\u0000","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139001920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-11DOI: 10.1097/ipc.0000000000001312
Basil Al-kaabneh, R. Alpizar-Rivas, S. Chuang, Purba Gupta
We report a rare case of a liver transplant recipient who experienced acute respiratory failure early posttransplantation because of cryptococcal pleural effusion. Although cryptococcal disease presenting solely as pleural effusion has been reported in the literature, it is not widely described in liver transplant recipients. Cryptococcal disease usually manifests late in the posttransplant period, whereas our patient was diagnosed with the infection early posttransplant. Diagnosis was made by pleural fluid culture. The initial serum cryptococcal antigen testing was negative. This case demonstrates the potential of subclinical or latent infections in patients with cirrhosis and liver transplant recipients and the importance of considering pleural fluid culture in the diagnostic evaluation of pleural effusions in cirrhotic patients.
{"title":"Cryptococcal Infection Presenting as a Pleural Effusion in a Liver Transplant Recipient","authors":"Basil Al-kaabneh, R. Alpizar-Rivas, S. Chuang, Purba Gupta","doi":"10.1097/ipc.0000000000001312","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001312","url":null,"abstract":"\u0000 We report a rare case of a liver transplant recipient who experienced acute respiratory failure early posttransplantation because of cryptococcal pleural effusion. Although cryptococcal disease presenting solely as pleural effusion has been reported in the literature, it is not widely described in liver transplant recipients. Cryptococcal disease usually manifests late in the posttransplant period, whereas our patient was diagnosed with the infection early posttransplant. Diagnosis was made by pleural fluid culture. The initial serum cryptococcal antigen testing was negative. This case demonstrates the potential of subclinical or latent infections in patients with cirrhosis and liver transplant recipients and the importance of considering pleural fluid culture in the diagnostic evaluation of pleural effusions in cirrhotic patients.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139010464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-11DOI: 10.1097/ipc.0000000000001319
Bilal Irfan, Ihsaan Yasin, Aneela Yaqoob
{"title":"TikTok's Role in the COVID-19 Pandemic: An Analysis of the Spread of Treatment Information","authors":"Bilal Irfan, Ihsaan Yasin, Aneela Yaqoob","doi":"10.1097/ipc.0000000000001319","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001319","url":null,"abstract":"","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138980139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-11DOI: 10.1097/ipc.0000000000001318
Maisam Amar, Gabriel Weber, Rabah Yassin, Ola Salah, Pninit Shaked Mishan, Maya Brudenski, Shereen Shehade, R. Najjar-Debbiny
Bacille Calmette-Guérin wash for urothelial carcinoma is a very common adjuvant treatment with a low potential for serious systemic adverse events. We present a case of a rare serious complication, empyema necessitans, following treatment with BCG. A 77-year-old patient with urothelial cancer treated with adjuvant BCG wash developed empyema due to Mycobacterium bovis related to his previous BCG exposure, which progressed to empyema necessitans treated with antituberculosis medications in conjugant with multiple thoracic drainages. Despite treatment, the patient's condition deteriorated slowly leading to death. Rare adverse events of common treatments should be considered when evaluating a patient, as BCG wash could potentially lead to empyema necessitans.
{"title":"Empyema Necessitans Following Bacille Calmette-Guérin Administration for Urothelial Carcinoma","authors":"Maisam Amar, Gabriel Weber, Rabah Yassin, Ola Salah, Pninit Shaked Mishan, Maya Brudenski, Shereen Shehade, R. Najjar-Debbiny","doi":"10.1097/ipc.0000000000001318","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001318","url":null,"abstract":"\u0000 \u0000 Bacille Calmette-Guérin wash for urothelial carcinoma is a very common adjuvant treatment with a low potential for serious systemic adverse events. We present a case of a rare serious complication, empyema necessitans, following treatment with BCG.\u0000 \u0000 \u0000 \u0000 A 77-year-old patient with urothelial cancer treated with adjuvant BCG wash developed empyema due to Mycobacterium bovis related to his previous BCG exposure, which progressed to empyema necessitans treated with antituberculosis medications in conjugant with multiple thoracic drainages. Despite treatment, the patient's condition deteriorated slowly leading to death.\u0000 \u0000 \u0000 \u0000 Rare adverse events of common treatments should be considered when evaluating a patient, as BCG wash could potentially lead to empyema necessitans.\u0000","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138978870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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