Pub Date : 2023-10-23DOI: 10.1097/ipc.0000000000001298
Miraç Öz, Nasser E. Absieha, Umut Dilegelen, Burak Alper Zengin, Kaan Gündüz, Ebru Evren, Sevgi Saryal
Abstract Syphilis is a multisystem infection caused by the spirochete Treponema pallidum . A 63-year-old man admitted to the hospital with chest pain and rashes on the chest wall and hands for 14 days. Thorax computed tomography revealed multiple nodular shadows in the bilateral lower lobes of the lung. Skin lesions were considered compatible with secondary syphilis. The antibody test for syphilis was positive. Screening for other associated sexually transmitted diseases (serology for HIV, hepatitis C, and hepatitis B) was negative. A specific therapy with crystallized penicillin G 2.4 MIU was applied. The key features for secondary syphilis diagnosis were positive serologic tests for syphilis and complete recovery on thorax computed tomography after antisyphilitic treatment. Pulmonary involvement in secondary syphilis is considered a rare occurrence.
{"title":"Secondary Syphilis With Pulmonary Involvement","authors":"Miraç Öz, Nasser E. Absieha, Umut Dilegelen, Burak Alper Zengin, Kaan Gündüz, Ebru Evren, Sevgi Saryal","doi":"10.1097/ipc.0000000000001298","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001298","url":null,"abstract":"Abstract Syphilis is a multisystem infection caused by the spirochete Treponema pallidum . A 63-year-old man admitted to the hospital with chest pain and rashes on the chest wall and hands for 14 days. Thorax computed tomography revealed multiple nodular shadows in the bilateral lower lobes of the lung. Skin lesions were considered compatible with secondary syphilis. The antibody test for syphilis was positive. Screening for other associated sexually transmitted diseases (serology for HIV, hepatitis C, and hepatitis B) was negative. A specific therapy with crystallized penicillin G 2.4 MIU was applied. The key features for secondary syphilis diagnosis were positive serologic tests for syphilis and complete recovery on thorax computed tomography after antisyphilitic treatment. Pulmonary involvement in secondary syphilis is considered a rare occurrence.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135412947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Spiritual Health Is a Neglected Need in the Mental Rehabilitation of Nurses After the COVID-19 Pandemic","authors":"Tahereh Yaghoubi, Rahmatollah Marzband, Seyed Hamzeh Hosseini, Fereshteh Araghian Mojarad","doi":"10.1097/ipc.0000000000001299","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001299","url":null,"abstract":"Yaghoubi, Tahereh; Marzband, Rahmatollah; Hosseini, Seyed Hamzeh; Mojarad, Fereshteh Araghian Author Information","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135367310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-23DOI: 10.1097/ipc.0000000000001302
Bilal Irfan, Ihsaan Yasin, Aneela Yaqoob
University of Michigan, Ann Arbor, MI [email protected] Beaumont Hospital, Taylor Taylor, MI. Conflict of Interest Disclosures: The authors declare there are no relevant conflicts of interest. Funding/Support: This research received no external funding.
利益冲突披露:作者声明不存在相关的利益冲突。资助/支持:本研究未获得外部资助。
{"title":"Considering Hijab and Niqab","authors":"Bilal Irfan, Ihsaan Yasin, Aneela Yaqoob","doi":"10.1097/ipc.0000000000001302","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001302","url":null,"abstract":"University of Michigan, Ann Arbor, MI [email protected] Beaumont Hospital, Taylor Taylor, MI. Conflict of Interest Disclosures: The authors declare there are no relevant conflicts of interest. Funding/Support: This research received no external funding.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135412784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-16DOI: 10.1097/ipc.0000000000001295
Ahmed Fathy Gomaa, Reda M. Elghmary, Mahmoud A. Sharafeddin, Salem Youssef Mohamed, Ayman Fathy Elsayed
Abstract Background Hyperglycemia is one of the most important independent risk factors that affect the prognosis and outcome of COVID-19 patients. Coronavirus disease 2019 infection is associated with poor glycemic control. This study's objectives were to determine the effect of hyperglycemia on the prognosis and outcome of COVID-19 patients and to detect whether COVID-19 infection can induce new-onset diabetes. Patients and Methods This cohort study was carried out on 240 hospitalized Egyptian COVID-19 patients, at Zagazig University Hospital isolation intensive care unit, between March 2020 and March 2021. They compared patients with diabetes and uncontrolled hyperglycemia against each other and COVID-19 patients without diabetes or uncontrolled hyperglycemia. Baseline demographic data, clinical features, and laboratory analysis were collected. Clinical outcome was evaluated via hospital stay and survival rate. Patients with uncontrolled hyperglycemia and nondiabetic patients were followed up 1 year after the hospital discharge to detect the development of new-onset diabetes. Result The diabetic group had the highest creatinine level, and the nondiabetic group had a minor C-reactive protein and D-dimer. The difference is significant between diabetic and nondiabetic groups concerning hospital stay. The nondiabetic group had the shortest hospital stay. There is a statistically substantial relationship between mortality and the glycosylated hemoglobin, serum creatinine, C-reactive protein, D-dimer, and serum ferritin. A total of 46.6% of survivors in the uncontrolled hyperglycemic group and 3.4% in the nondiabetic group developed diabetes mellitus during follow-up. There is a statistically significant relationship between new-onset diabetes mellitus and D-dimer. Conclusions Coronavirus disease 2019 can induce diabetes mellitus in vulnerable patients (presented with uncontrolled hyperglycemia at admission). In addition, COVID-19 patients with diabetes or uncontrolled hyperglycemia have worse outcomes and poor prognoses.
{"title":"COVID-19 Infection and Diabetes","authors":"Ahmed Fathy Gomaa, Reda M. Elghmary, Mahmoud A. Sharafeddin, Salem Youssef Mohamed, Ayman Fathy Elsayed","doi":"10.1097/ipc.0000000000001295","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001295","url":null,"abstract":"Abstract Background Hyperglycemia is one of the most important independent risk factors that affect the prognosis and outcome of COVID-19 patients. Coronavirus disease 2019 infection is associated with poor glycemic control. This study's objectives were to determine the effect of hyperglycemia on the prognosis and outcome of COVID-19 patients and to detect whether COVID-19 infection can induce new-onset diabetes. Patients and Methods This cohort study was carried out on 240 hospitalized Egyptian COVID-19 patients, at Zagazig University Hospital isolation intensive care unit, between March 2020 and March 2021. They compared patients with diabetes and uncontrolled hyperglycemia against each other and COVID-19 patients without diabetes or uncontrolled hyperglycemia. Baseline demographic data, clinical features, and laboratory analysis were collected. Clinical outcome was evaluated via hospital stay and survival rate. Patients with uncontrolled hyperglycemia and nondiabetic patients were followed up 1 year after the hospital discharge to detect the development of new-onset diabetes. Result The diabetic group had the highest creatinine level, and the nondiabetic group had a minor C-reactive protein and D-dimer. The difference is significant between diabetic and nondiabetic groups concerning hospital stay. The nondiabetic group had the shortest hospital stay. There is a statistically substantial relationship between mortality and the glycosylated hemoglobin, serum creatinine, C-reactive protein, D-dimer, and serum ferritin. A total of 46.6% of survivors in the uncontrolled hyperglycemic group and 3.4% in the nondiabetic group developed diabetes mellitus during follow-up. There is a statistically significant relationship between new-onset diabetes mellitus and D-dimer. Conclusions Coronavirus disease 2019 can induce diabetes mellitus in vulnerable patients (presented with uncontrolled hyperglycemia at admission). In addition, COVID-19 patients with diabetes or uncontrolled hyperglycemia have worse outcomes and poor prognoses.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136112525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-16DOI: 10.1097/ipc.0000000000001305
Mounika Binkam, John N. Greene, Stephanie M. Oehler, Christy Thai, Björn Holmström
Abstract An increased risk of venous thromboembolism (VTE) with COVID-19 infection has been well documented, particularly in critically ill-hospitalized patients. The presence of cancer, in addition to several anticancer treatments, can further elevate the risk of VTE. The following case reports describe an increased risk of extensive thrombosis that can be seen with COVID-19 infection in cancer patients. We report 3 cases of pulmonary embolism and deep vein thrombosis in cancer patients with COVID-19 infection. All 3 cases are unique with the timeline of COVID-19 infection and diagnosis of VTE. The current pandemic has alerted the clinician to the potential increased risk for thrombus formation in cancer patients with COVID-19, even days to months after acute infection.
{"title":"Thromboembolism in Cancer Patients With COVID-19 Infection Compared With Other Infections—A Case Series","authors":"Mounika Binkam, John N. Greene, Stephanie M. Oehler, Christy Thai, Björn Holmström","doi":"10.1097/ipc.0000000000001305","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001305","url":null,"abstract":"Abstract An increased risk of venous thromboembolism (VTE) with COVID-19 infection has been well documented, particularly in critically ill-hospitalized patients. The presence of cancer, in addition to several anticancer treatments, can further elevate the risk of VTE. The following case reports describe an increased risk of extensive thrombosis that can be seen with COVID-19 infection in cancer patients. We report 3 cases of pulmonary embolism and deep vein thrombosis in cancer patients with COVID-19 infection. All 3 cases are unique with the timeline of COVID-19 infection and diagnosis of VTE. The current pandemic has alerted the clinician to the potential increased risk for thrombus formation in cancer patients with COVID-19, even days to months after acute infection.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136112539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-16DOI: 10.1097/ipc.0000000000001327
M. Gabriela Cabanilla, Scott V. Norville
From the ∗Division of Infectious Diseases, Department of Pharmacy †Division of Infectious Diseases, University of New Mexico Health Sciences Center, Albuquerque, NM. Correspondence to: M. Gabriela Cabanilla, PharmD, PhC, Division of Infectious Diseases, Department of Pharmacy, University of New Mexico Health Sciences Center, 2211 Lomas Blvd NE, Albuquerque, NM 87106. E-mail: [email protected]. M. Gabriela Cabanilla ORCID ID: 0000-0001-5402-0240 The authors have no funding or conflicts of interest to disclose.
{"title":"Large Unidentified Neck Mass in an Immunocompetent Patient","authors":"M. Gabriela Cabanilla, Scott V. Norville","doi":"10.1097/ipc.0000000000001327","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001327","url":null,"abstract":"From the ∗Division of Infectious Diseases, Department of Pharmacy †Division of Infectious Diseases, University of New Mexico Health Sciences Center, Albuquerque, NM. Correspondence to: M. Gabriela Cabanilla, PharmD, PhC, Division of Infectious Diseases, Department of Pharmacy, University of New Mexico Health Sciences Center, 2211 Lomas Blvd NE, Albuquerque, NM 87106. E-mail: [email protected]. M. Gabriela Cabanilla ORCID ID: 0000-0001-5402-0240 The authors have no funding or conflicts of interest to disclose.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136114712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Ophthalmic manifestation in Microsporidium spp. was observed in this patient having experienced decreased vision at the right eye for 1 month. The patient worked as an organic farmer. She was at risk because of exposure to water while watering plants. The confocal microscopy performed on the right eye showed marked dendritic cells. The corneal biopsy was proven by tiny dot-like organisms in acid-fast stain and modified acid-fast stain. In addition, the positive polymerase chain reaction test result for Microsporidium spp. supported the diagnosis. The patient was treated with an intensive course of topical biguanides, antimicrobial agents, and penetrating keratoplasty.
{"title":"Microsporidial Stromal Keratitis, a Case Report","authors":"Monchai Duangpraphat, Dhitiwat Changpradub, Worawong Chueansuwan","doi":"10.1097/ipc.0000000000001300","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001300","url":null,"abstract":"Abstract Ophthalmic manifestation in Microsporidium spp. was observed in this patient having experienced decreased vision at the right eye for 1 month. The patient worked as an organic farmer. She was at risk because of exposure to water while watering plants. The confocal microscopy performed on the right eye showed marked dendritic cells. The corneal biopsy was proven by tiny dot-like organisms in acid-fast stain and modified acid-fast stain. In addition, the positive polymerase chain reaction test result for Microsporidium spp. supported the diagnosis. The patient was treated with an intensive course of topical biguanides, antimicrobial agents, and penetrating keratoplasty.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136112938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-16DOI: 10.1097/ipc.0000000000001313
Heeral Thakkar, Palaniraj Rama Raj, Annaleise R. Howard-Jones, Paul Adler, Vidthiya Menon
Abstract Nocardia spp are an uncommon cause of central nervous system infections and particularly endophthalmitis. In this case report, we present the first documented case of endogenous Nocardia paucivorans endophthalmitis and subretinal abscesses. We also provide a brief summary of the literature regarding ocular and cerebral nocardiosis. Early diagnosis and management improve outcomes; hence, clinicians should be cognizant of Nocardia infection as a differential diagnosis in cases of cerebral abscess or endophthalmitis, including in the immunocompetent.
{"title":"Nocardia paucivorans Endophthalmitis and Cerebral Abscesses in an Immunocompetent Patient","authors":"Heeral Thakkar, Palaniraj Rama Raj, Annaleise R. Howard-Jones, Paul Adler, Vidthiya Menon","doi":"10.1097/ipc.0000000000001313","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001313","url":null,"abstract":"Abstract Nocardia spp are an uncommon cause of central nervous system infections and particularly endophthalmitis. In this case report, we present the first documented case of endogenous Nocardia paucivorans endophthalmitis and subretinal abscesses. We also provide a brief summary of the literature regarding ocular and cerebral nocardiosis. Early diagnosis and management improve outcomes; hence, clinicians should be cognizant of Nocardia infection as a differential diagnosis in cases of cerebral abscess or endophthalmitis, including in the immunocompetent.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136115986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-06DOI: 10.1097/ipc.0000000000001307
Lucio Boglione, Federica Poletti, Roberto Rostagno, Roberta Moglia, Marco Cantone, Maria Esposito, Silvio Borrè
Introduction Neutralizing monoclonal antibodies (NmAbs) are a treatment option in patients with early SARS-CoV-2 infection. In this study, we examined the role of NmAbs therapies in a cohort of patients affected by nosocomial COVID-19 infection and high risk of illness progression. Methods A retrospective, single-center analysis was performed including all patients affected by nosocomial SARS-CoV-2 infection receiving NmAbs treatment between April 2021 and March 2022. Results The overall included patients were 75. Mortality rate was 13.3%; disease progression was observed in 22 patients (29.3%); clinical improvement was reported in 49 subjects (65.3%). In multivariate logistic regression, the presence of immunosuppression risk factor and late administration of therapies were recognized as independent predictors of treatment failure. Conclusions In this real-world analysis, the treatment with NmAbs was safety and effectiveness in high-risk patients with nosocomial COVID-19 infection, but the timing of administration and the role of viral variants are the main limiting factors of this approach.
{"title":"Real-World Outcomes of Neutralizing Monoclonal Antibody Treatment in Patients Affected by Nosocomial Coronavirus Disease 2019","authors":"Lucio Boglione, Federica Poletti, Roberto Rostagno, Roberta Moglia, Marco Cantone, Maria Esposito, Silvio Borrè","doi":"10.1097/ipc.0000000000001307","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001307","url":null,"abstract":"Introduction Neutralizing monoclonal antibodies (NmAbs) are a treatment option in patients with early SARS-CoV-2 infection. In this study, we examined the role of NmAbs therapies in a cohort of patients affected by nosocomial COVID-19 infection and high risk of illness progression. Methods A retrospective, single-center analysis was performed including all patients affected by nosocomial SARS-CoV-2 infection receiving NmAbs treatment between April 2021 and March 2022. Results The overall included patients were 75. Mortality rate was 13.3%; disease progression was observed in 22 patients (29.3%); clinical improvement was reported in 49 subjects (65.3%). In multivariate logistic regression, the presence of immunosuppression risk factor and late administration of therapies were recognized as independent predictors of treatment failure. Conclusions In this real-world analysis, the treatment with NmAbs was safety and effectiveness in high-risk patients with nosocomial COVID-19 infection, but the timing of administration and the role of viral variants are the main limiting factors of this approach.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134945450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Peritoneal tuberculosis (PT) is the most common form of abdominal tuberculosis. Diagnosis of PT can be difficult because of vague clinical symptoms, insidious onset, limitations of available diagnostic tests, and variable imaging findings. Early and timely diagnosis and treatment are important in preventing morbidity and mortality in PT. In this review, we summarize the current literature on presentation, diagnosis, and management of PT.
{"title":"Peritoneal Tuberculosis","authors":"Nazli Begum Ozturk, Christos Tsagkaris, Raim Iliaz","doi":"10.1097/ipc.0000000000001310","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001310","url":null,"abstract":"Abstract Peritoneal tuberculosis (PT) is the most common form of abdominal tuberculosis. Diagnosis of PT can be difficult because of vague clinical symptoms, insidious onset, limitations of available diagnostic tests, and variable imaging findings. Early and timely diagnosis and treatment are important in preventing morbidity and mortality in PT. In this review, we summarize the current literature on presentation, diagnosis, and management of PT.","PeriodicalId":13952,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134945451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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