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Building medical toxicology capacity in Africa: a review and strategic perspective on the need for fellowship training programs. 非洲医学毒理学能力建设:对研究金培训方案需求的审查和战略观点。
IF 2 Q2 EMERGENCY MEDICINE Pub Date : 2025-12-19 DOI: 10.1186/s12245-025-01098-6
Belayneh Dessie Kassa
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引用次数: 0
Injury epidemiology of inflatable amusement devices: a level I trauma center experience. 充气游乐设备损伤流行病学:一级创伤中心经验。
IF 2 Q2 EMERGENCY MEDICINE Pub Date : 2025-12-18 DOI: 10.1186/s12245-025-01100-1
Joseph Larson, Jacob Amann, Joyce McRae, Mark Kashtan, Amna Minhas, Benjamin A Farber, Andrei Radulescu, Donald Moores
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引用次数: 0
Conservative management of spontaneous thoracolumbar epidural hematoma: a case report. 自发性胸腰椎硬膜外血肿的保守治疗1例。
IF 2 Q2 EMERGENCY MEDICINE Pub Date : 2025-12-16 DOI: 10.1186/s12245-025-01105-w
Menglong Jia, Shan Gao, Longtan Yu, Guangbin Ma

Background: Spontaneous spinal epidural hematoma (SSEH) is an exceedingly rare clinical entity often associated with neurological deficits, for which surgical intervention remains the mainstay of treatment. We report a case successfully managed through complete conservative therapy.

Case presentation: A 59-year-old Chinese male with a medical history of hypertension, chronic smoking, and alcohol use presented to our institution with acute-onset low back pain accompanied by bilateral lower limb weakness and hypoesthesia persisting for 30 min. Diagnostic imaging (CT and MRI) revealed a thoracolumbar epidural hematoma (T11-L1 distribution). Contrary to conventional surgical management paradigms, we implemented a comprehensive conservative management protocol. Remarkably, complete resolution of symptoms and spontaneous hematoma absorption were achieved within 20 days.

Conclusion: This case demonstrates that select SSEH cases may achieve favorable outcomes through conservative management without surgical decompression.

背景:自发性脊髓硬膜外血肿(SSEH)是一种极其罕见的临床疾病,通常与神经功能障碍有关,手术干预仍然是治疗的主要手段。我们报告一个通过完全保守治疗成功管理的病例。病例介绍:一名59岁中国男性,既往有高血压、慢性吸烟和饮酒史,因急性腰痛伴双侧下肢无力和感觉减退持续30分钟而来我院就诊。诊断影像(CT和MRI)显示胸腰段硬膜外血肿(T11-L1分布)。与传统的手术管理模式相反,我们实施了全面的保守管理方案。值得注意的是,症状完全缓解,自发性血肿吸收在20天内实现。结论:本病例表明,选择性SSEH病例通过保守治疗无需手术减压,可获得良好的预后。
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引用次数: 0
Abdominal computed tomography use in the emergency department among children with abdominal pain: a retrospective analysis. 腹部计算机断层扫描在急诊科对腹痛患儿的应用:回顾性分析。
IF 2 Q2 EMERGENCY MEDICINE Pub Date : 2025-12-16 DOI: 10.1186/s12245-025-01087-9
Sarah Khafaja, Sarah Salam Rizk, Samer El Hayek, Nadine Yazbeck
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引用次数: 0
Anaphylactic shock following intravenous ranitidine in rural Nepal: a case report. 尼泊尔农村静脉注射雷尼替丁后过敏性休克1例报告。
IF 2 Q2 EMERGENCY MEDICINE Pub Date : 2025-12-16 DOI: 10.1186/s12245-025-01101-0
Rojee Shrestha, Ashal Timalsina, Arjun Gaire, Roshan Acharya, Anupa Subedi, Aayusha Suwal

Background: Ranitidine, a histamine-2 (H2) receptor antagonist, is widely used for acid-peptic disorders. Although generally safe, it is a rare but recognized cause of drug-induced anaphylaxis, with an estimated incidence of 0.2-0.7% for H2 receptor blockers and proton pump inhibitors. We report a near-fatal case of ranitidine-induced anaphylactic shock successfully managed in a rural hospital.

Case presentation: A 35-year-old female developed sudden shortness of breath, hypotension, and drowsiness within minutes of receiving a 50 mg intravenous (IV) dose of ranitidine for epigastric discomfort at a local clinic. She had no prior exposure to ranitidine or known allergies. On arrival, her blood pressure was 60 mmHg systolic, pulse 130/min, and SpO₂ 60%. She had diffused urticaria and wheezing. A diagnosis of anaphylactic shock was made. Immediate management included high-flow oxygen, intramuscular epinephrine (0.5 mg, 1:1000), followed by intravenous hydrocortisone. Significant improvement occurred within 10 minutes and she was discharged after 24 hours of observation.

Conclusion: This case highlights that ranitidine, although commonly used, can rarely trigger severe anaphylactic shock even in patients without prior exposure or known allergies. Early recognition of the reaction and timely administration of intramuscular epinephrine were key to the patient's rapid recovery. Awareness of this potential adverse reaction is important for all clinicians who administer H2-receptor antagonists.

背景:雷尼替丁是一种组胺-2 (H2)受体拮抗剂,广泛用于酸消化性疾病。虽然通常是安全的,但它是一种罕见但公认的药物性过敏反应的原因,H2受体阻滞剂和质子泵抑制剂的发生率估计为0.2-0.7%。我们报告一个几乎致命的病例雷尼替丁引起的过敏性休克成功地管理在农村医院。病例介绍:一名35岁女性在当地诊所接受50mg雷尼替丁静脉注射治疗上腹部不适后,几分钟内突然出现呼吸短促、低血压和嗜睡。她之前没有接触过雷尼替丁或已知的过敏。到达时,她的收缩压为60毫米汞柱,脉搏130/分钟,SpO₂为60%。她患有弥漫性荨麻疹和喘息。诊断为过敏性休克。立即处理包括高流量氧气,肌肉注射肾上腺素(0.5 mg, 1:1000),然后静脉注射氢化可的松。10分钟内出现明显改善,观察24小时后出院。结论:本病例强调雷尼替丁虽然被广泛使用,但很少会引发严重的过敏性休克,即使在没有暴露或已知过敏的患者中也是如此。早期识别反应并及时给予肌注肾上腺素是患者快速康复的关键。意识到这种潜在的不良反应对所有使用h2受体拮抗剂的临床医生都很重要。
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引用次数: 0
Evaluation of road infrastructure in Yerevan, Armenia through the lens of pedestrian and child safety: a school-based analysis. 从行人和儿童安全的角度评价亚美尼亚埃里温的道路基础设施:基于学校的分析。
IF 2 Q2 EMERGENCY MEDICINE Pub Date : 2025-12-12 DOI: 10.1186/s12245-025-01070-4
Emily N Terian, Haig J Minasian, Jefrin Johny, Araksya Gevorgyan, Sharon A Chekijian

Introduction: Traffic-related injury is a leading cause of morbidity and mortality globally, especially among children. In Armenia, traffic-related mortality rates are the second highest among European Union and former Soviet countries. Currently, there are no published studies on pedestrian safety in Armenia and no notable examinations of pedestrian safety infrastructure. This manuscript describes an audit of Armenia's infrastructure using a modified Inventory for Pedestrian Safety Infrastructure (IPSI) in the Yerevan city center, focusing on areas surrounding schools.

Methods: Intersections (n = 379) and roadways (n = 623) shared by pedestrians and drivers in Yerevan's center were audited using a 36-item modified ISPI and paired with cloud-based smartphone application QField between October 2023 and February 2024. Visual analysis of data was conducted using the open-source software QGIS with statistical analysis in R. Inter-rater reliability of the audit was calculated using Cohen's Kappa and intra-class correlation coefficients. Incidence of each feature surrounding schools was compared to incidence overall using a one-sample z-test for continuous variables and a two-sample test of proportions for binary variables.

Results: Many of the features audited were not observed consistently across the audited area and were not more prevalent near schools. Lower inter-rater reliability was found with roadway and midblock data, resulting in analysis of primarily intersection features. Speed limits surrounding schools varied from 20 to 60 km/hr (12.5-37 mph). When compared to the overall audited area, crosswalks near schools demonstrated similar occurrence for traffic lights with crosswalk markings (23.3%, 95% CI: 0.157-0.309), speed bumps (11.9%, 95% CI: -0.139- 0.0338), and pedestrian signals (12.9%, 95% CI: 0.0709-0.194). Of the analyzed items, only bus stops were observed significantly more often near schools (19%, 95% CI: 0.00930-0.220).

Conclusions: The audit revealed an inconsistent presence of safety infrastructure, with infrastructure near schools largely reflecting the overall audited area. However, analysis was limited by low inter-rater reliability for many roadway and midblock features audited. Based on these results, infrastructure changes targeting lower speed limits and increased traffic calming measures are recommended to improve safety in school zones. Given a paucity of studies in LMICs, further work must be done to identify which high-yield features should be targeted in LMICs to prevent injury.

导言:交通伤害是全球发病和死亡的主要原因,尤其是儿童。在亚美尼亚,与交通有关的死亡率在欧洲联盟和前苏联国家中排名第二。目前,没有发表过关于亚美尼亚行人安全的研究,也没有对行人安全基础设施进行过显著的检查。本文描述了在埃里温市中心使用改进的行人安全基础设施清单(IPSI)对亚美尼亚基础设施的审计,重点是学校周边地区。方法:在2023年10月至2024年2月期间,使用36项改进的ISPI并与基于云的智能手机应用QField配对,对埃里温中心行人和司机共用的十字路口(n = 379)和道路(n = 623)进行审计。采用开源软件QGIS对数据进行可视化分析,并进行统计分析。采用Cohen’s Kappa和类内相关系数计算审计的等级间信度。使用连续变量的单样本z检验和二元变量的双样本比例检验,将学校周围每个特征的发生率与总体发生率进行比较。结果:许多被审计的特征在整个被审计区域并没有一致地观察到,并且在学校附近并不普遍。由于巷道和中段数据的可靠性较低,导致分析的主要是交叉口特征。学校周围的限速从20到60公里每小时(12.5-37英里每小时)不等。与整个审计区域相比,学校附近人行横道的交通灯(23.3%,95% CI: 0.157-0.309)、减速带(11.9%,95% CI: -0.139- 0.0338)和行人信号(12.9%,95% CI: 0.0709-0.194)的发生率相似。在分析的项目中,只有公交车站在学校附近被观察到的频率明显更高(19%,95% CI: 0.00930-0.220)。结论:审计发现安全基础设施的存在不一致,学校附近的基础设施在很大程度上反映了整个审计区域。然而,对于许多被审计的巷道和中段特征,分析受到了低可靠性的限制。基于这些结果,建议对基础设施进行改造,降低限速,增加交通平静措施,以提高学区的安全。鉴于对中低收入国家的研究不足,必须做进一步的工作来确定中低收入国家应该针对哪些高产特征来防止伤害。
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引用次数: 0
Haemorrhagic stroke in the Democratic Republic of the Congo: a neglected neurosurgical emergency care in a health system with critical gaps: a mini review. 刚果民主共和国出血性中风:存在严重缺口的卫生系统中被忽视的神经外科急诊护理:一项小型审查。
IF 2 Q2 EMERGENCY MEDICINE Pub Date : 2025-12-12 DOI: 10.1186/s12245-025-01016-w
Franck Katembo Sikakulya, Larrey Kasereka Kamabu, Kantenga Dieu Merci Kabulo, Jeff Ntalaja, Hervé Monka Lekuya

Haemorrhagic stroke, caused by bleeding in the brain, is one of the most dangerous types of stroke. It kills many people and leaves others with lifelong disabilities. In the Democratic Republic of the Congo (DRC), this problem is serious but often ignored. While most strokes in wealthy countries are caused by blocked blood vessels, in Africa, a much larger number are caused by bleeding. In the DRC, the problem is that stroke patients often arrive late at hospitals, and most hospitals do not have brain imaging or enough specialised stroke staff to treat them promptly. The country has fewer than 20 neurosurgeons for more than 100 million people, and most of them work in major cities. People living in rural areas usually cannot access proper care. Even when patients arrive at a hospital, surgery and intensive care are often unavailable. Stroke is usually managed as part of general health programmes, but the surgical aspect of haemorrhagic stroke is rarely included. This results in many deaths that could be prevented. This paper examines haemorrhagic stroke in the DRC from a neurosurgical perspective. We highlight how the lack of specialists, equipment, and clear treatment protocols worsens the situation. Simultaneously, there are opportunities for improvement: training general doctors and nurses in basic neurosurgical care, utilising telemedicine for advice, and developing national policies that include surgery. Collecting better data and establishing global partnerships will also be beneficial. Increasing focus on haemorrhagic stroke can save lives and reduce disabilities in the DRC.

出血性中风由脑出血引起,是最危险的中风类型之一。它杀死了许多人,并使其他人终身残疾。在刚果民主共和国(DRC),这个问题很严重,但往往被忽视。虽然富裕国家的大多数中风是由血管阻塞引起的,但在非洲,由出血引起的中风要多得多。在刚果民主共和国,问题在于中风患者往往到达医院较晚,而且大多数医院没有脑成像设备或足够的专业中风工作人员来及时治疗他们。这个国家有1亿多人口,却只有不到20名神经外科医生,他们中的大多数在大城市工作。生活在农村地区的人通常无法获得适当的护理。即使病人被送到医院,外科手术和重症监护也常常无法获得。中风通常作为一般卫生规划的一部分进行管理,但出血性中风的手术方面很少包括在内。这导致了许多本可以避免的死亡。本文检查出血性中风在刚果民主共和国从神经外科的角度。我们强调缺乏专家、设备和明确的治疗方案如何使情况恶化。同时,还有改进的机会:培训全科医生和护士进行基本的神经外科护理,利用远程医疗提供建议,以及制定包括外科在内的国家政策。收集更好的数据和建立全球伙伴关系也将是有益的。在刚果民主共和国,加强对出血性中风的关注可以挽救生命并减少残疾。
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引用次数: 0
Developing a conceptual framework to facilitate inter-organizational partnership in disasters and public health emergencies. 制定一个概念性框架,以促进灾害和突发公共卫生事件中的组织间伙伴关系。
IF 2 Q2 EMERGENCY MEDICINE Pub Date : 2025-12-12 DOI: 10.1186/s12245-025-01027-7
Jonas Zimmerman, Amir Khorram-Manesh, Eric Carlström, Yohan Robinson, Joakim Björås

Introduction: Disasters and public health emergencies can overwhelm healthcare systems, requiring rapid increase in capacity, inter-agency collaboration, and the quick deployment of emergency medical teams. An effective response to these crises requires a structured approach that integrates multiple entities, including healthcare, military, and community organizations. Current frameworks often lack structured methods for optimizing collaboration, which can lead to redundancy and inefficiency. This study aims to address this gap by developing a conceptual framework combining collaboration and integration theories to improve inter-organizational partnerships in emergency management.

Methods: To develop this framework, a comprehensive literature review was conducted identifying gaps in existing theoretical models of integration and collaboration. We examined integration theory at five distinct levels: structural, functional, normative, interpersonal, and process. Simultaneously, we explored collaboration theory, focusing on socio-cognitive, intersubjectivity, and distributed cognition frameworks. The study then synthesized these theories into a new, combined framework. This framework aligns integration components with key collaborative principles such as shared decision-making, effective communication, and adaptability. To make this framework a practical tool, we incorporated the CSCATTT model (Command and Control, Safety, Communication, Assessment, Triage, Treatment, Transport). This model typically used in collaborative exercises, serves as a practical guide for implementing and evaluating collaboration in real-world scenarios.

Results: The proposed framework provides a structured approach for responding to disasters and public health emergencies by identifying key points where integration and collaboration can effectively be combined. It demonstrates that integration theory ensures system cohesion and operational efficiency, while collaboration theory fosters adaptability and stakeholder engagement. By aligning these two theories, the framework facilitates more effective multi-agency partnerships. The inclusion of the CSCATTT model enhances structured decision-making, enabling coordinated and efficient action during emergencies.

Conclusion: By integrating collaboration and integration theories, this study offers a robust model for enhancing partnerships during disasters and public health emergencies. The proposed framework improves resource utilization, inter-agency coordination, cooperation, and overall effectiveness of collaborative responses, all while maintaining system flexibility. Future research should focus on validating this framework through practical applications, such as simulation exercises and real-world deployments.

灾害和突发公共卫生事件可能使卫生保健系统不堪重负,需要迅速提高能力,开展机构间合作,并迅速部署应急医疗队。要对这些危机作出有效的反应,就需要采取一种整合多个实体(包括医疗保健、军事和社区组织)的结构化方法。当前的框架通常缺乏优化协作的结构化方法,这可能导致冗余和低效率。本研究旨在通过发展一个结合协作和整合理论的概念框架来解决这一差距,以改善应急管理中的组织间伙伴关系。方法:为了构建这一框架,我们进行了全面的文献综述,找出现有整合与协作理论模型中的空白。我们从五个不同的层面考察整合理论:结构、功能、规范、人际关系和过程。同时,我们探讨了协作理论,重点是社会认知、主体间性和分布式认知框架。然后,该研究将这些理论综合到一个新的组合框架中。该框架将集成组件与关键的协作原则(如共享决策、有效通信和适应性)结合在一起。为了使这个框架成为一个实用的工具,我们纳入了CSCATTT模型(指挥与控制、安全、通信、评估、分类、治疗、运输)。该模型通常用于协作练习,作为在真实场景中实现和评估协作的实用指南。结果:拟议的框架通过确定整合与协作可以有效结合的关键点,为应对灾害和突发公共卫生事件提供了一种结构化方法。研究表明,整合理论保证了系统的内聚性和运行效率,而协作理论则促进了系统的适应性和利益相关者的参与。通过将这两种理论结合起来,该框架促进了更有效的多机构伙伴关系。CSCATTT模式的加入加强了有组织的决策,使紧急情况下能够采取协调和有效的行动。结论:通过整合协作和整合理论,本研究为灾害和突发公共卫生事件中加强伙伴关系提供了一个稳健的模型。拟议的框架提高了资源利用、机构间协调、合作和协作响应的总体有效性,同时保持了系统的灵活性。未来的研究应该集中在通过实际应用来验证这个框架,比如模拟练习和真实世界的部署。
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引用次数: 0
Anomalous right coronary artery stemming from left coronary sinus and malignant interarterial course in a middle-aged woman: a case report and review of diagnostic and surgical management. 中年妇女左冠状动脉窦引起的右冠状动脉异常及恶性动脉间病程:1例报告及诊断及手术治疗回顾。
IF 2 Q2 EMERGENCY MEDICINE Pub Date : 2025-12-09 DOI: 10.1186/s12245-025-01042-8
Arya Khezrpour, Mehran Abdollahi, Pouya Ebrahimi, Amin Zaki Zadeh, Nazanin Rafiei, Sara Montazeri Namin, Pedram Ramezani, Touba Akbari, Mohammad Hossein Mandegar
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引用次数: 0
Preliminary investigation of bacterial surface contamination in emergency ambulances in South Korea. 韩国紧急救护车表面细菌污染的初步调查。
IF 2 Q2 EMERGENCY MEDICINE Pub Date : 2025-12-05 DOI: 10.1186/s12245-025-01083-z
Seoul-Hee Nam, Hyeon-Ji Lee, Mi-Young Choi

Background: Emergency ambulances are vital in prehospital care but carry a high risk of healthcare-associated infections due to confined spaces, high patient turnover, and brief cleaning intervals. Routine disinfection protocols are in place; however, their effectiveness in South Korean ambulances has not been formally evaluated.

Methods: This pre-post observational study examined bacterial contamination on six high-touch surfaces across five operational ambulances in Province G, South Korea. Swabs were collected immediately before and after daily disinfection performed by paramedics. Bacterial load was quantified using colony-forming units (CFUs), and species identification was conducted via 16 S rRNA sequencing. Statistical analyses included paired t-tests, ANOVA, Cohen's d, and MANOVA to evaluate the cleaning efficacy and contamination patterns.

Results: All six surfaces were contaminated before cleaning, with the highest CFUs recorded on the ventilation outlet (182.6 ± 48.3), SpO₂ sensor (145.2 ± 35.7), and stretcher handle (122.4 ± 22.6). Disinfection significantly reduced bacterial load across all surfaces (p < 0.05), yet residual contamination remained on the SpO₂ sensor (Bacillus velezensis) and stretcher handle (Williamsia muralis). ANOVA revealed significant differences in baseline contamination (F(5,24) = 78.52, p < 0.001), and MANOVA confirmed that cleaning effectiveness varied by surface geometry (Wilks' Λ = 0.202, p < 0.001).

Conclusions: Manual disinfection significantly lowers bacterial load in ambulances, but residual contamination on complex, high-touch surfaces remains problematic. These findings underscore the need for multimodal disinfection approaches, improved equipment design, and systematic microbial surveillance to enhance EMS infection control standards.

背景:紧急救护车在院前护理中至关重要,但由于空间狭窄,患者流动率高,清洗间隔短,因此具有较高的卫生保健相关感染风险。有常规消毒方案;然而,它们在韩国救护车上的有效性尚未得到正式评估。方法:这项前后观察性研究检查了韩国G省5辆运营救护车的6个高接触表面的细菌污染。在护理人员进行日常消毒之前和之后立即收集拭子。采用菌落形成单位(colony forming units, cfu)定量细菌负荷,采用16s rRNA测序进行菌种鉴定。统计分析包括配对t检验、方差分析、Cohen’s d和方差分析,以评估清洁效果和污染模式。结果:清洗前6个表面均有污染,其中通风口CFUs最高(182.6±48.3),SpO₂传感器最高(145.2±35.7),担架手柄最高(122.4±22.6)。结论:手动消毒可显著降低救护车中的细菌负荷,但复杂、高接触表面的残留污染仍然是一个问题。这些发现强调需要采用多模式消毒方法、改进设备设计和系统的微生物监测来提高EMS感染控制标准。
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引用次数: 0
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International Journal of Emergency Medicine
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